Glucocorticoid Receptor Antagonists

Cat.No.	Product Name	Information	Product Use Citations
S6608	AL082D06	AL082D06 is a nonsteroidal glucocorticoid receptor (GR) antagonist with no detectable binding affinity for the highly related receptors for mineralocorticoids, androgens, estrogens, and progestins.	eLife, 2025, e93183 International Journal of Molecular Sciences, 2023, 11700 Int J Mol Sci, 2023, 24(14)11700
S2606	Mifepristone (RU-486)	Mifepristone is a remarkably active antagonist of progesterone receptor and glucocorticoid receptor with IC50 of 0.2 nM and 2.6 nM, respectively. Mifepristone promotes cell autophagy and apoptosis, decreases Bcl-2 level and increases Beclin1 level, accompanied by weakened interaction between Bcl-2 and Beclin1.Mifepristone (RU486) can be used to induce animal models of Spontaneous Abortion.	Pharmacol Res, 2025, 215:107696 Cell Death Dis, 2025, 16(1):237 J Virol, 2025, 99(2):e0147224
E1091	Relacorilant (CORT125134)	Relacorilant (CORT125134) is a potent, selective and orally bioavailable glucocorticoid receptor antagonist, with a Ki of 7.2 nM in HepG2 TAT assay, and also shows Kis of 12, 81.2, 210 nM for rat, human and monkey glucocorticoid receptor in cell-based assay, respectively.	Biomed Pharmacother, 2024, 180:117523 Journal of Endocrinological Investigation, 2023, 1-14 J Endocrinol Invest, 2023, 10.1007/s40618-023-02184-3

Cat.No.

Product Name

Information

Product Use Citations

Product Validations

S6608

AL082D06

AL082D06 is a nonsteroidal glucocorticoid receptor (GR) antagonist with no detectable binding affinity for the highly related receptors for mineralocorticoids, androgens, estrogens, and progestins.

eLife, 2025, e93183

International Journal of Molecular Sciences, 2023, 11700

Int J Mol Sci, 2023, 24(14)11700

S2606

Mifepristone (RU-486)

Mifepristone is a remarkably active antagonist of progesterone receptor and glucocorticoid receptor with IC50 of 0.2 nM and 2.6 nM, respectively. Mifepristone promotes cell autophagy and apoptosis, decreases Bcl-2 level and increases Beclin1 level, accompanied by weakened interaction between Bcl-2 and Beclin1.Mifepristone (RU486) can be used to induce animal models of Spontaneous Abortion.

Pharmacol Res, 2025, 215:107696

Cell Death Dis, 2025, 16(1):237

J Virol, 2025, 99(2):e0147224

Verified customer review of Mifepristone (RU-486)

E1091

Relacorilant (CORT125134)

Relacorilant (CORT125134) is a potent, selective and orally bioavailable glucocorticoid receptor antagonist, with a Ki of 7.2 nM in HepG2 TAT assay, and also shows Kis of 12, 81.2, 210 nM for rat, human and monkey glucocorticoid receptor in cell-based assay, respectively.

Biomed Pharmacother, 2024, 180:117523

Journal of Endocrinological Investigation, 2023, 1-14

J Endocrinol Invest, 2023, 10.1007/s40618-023-02184-3