Glucocorticoid Receptor Antagonists

Cat.No.	Product Name	Information	Product Use Citations
S6608	AL082D06	AL082D06 is a nonsteroidal glucocorticoid receptor (GR) antagonist with no detectable binding affinity for the highly related receptors for mineralocorticoids, androgens, estrogens, and progestins.	Int J Mol Sci, 2023, 24(14)11700
S2606	Mifepristone (RU-486)	Mifepristone is a remarkably active antagonist of progesterone receptor and glucocorticoid receptor with IC50 of 0.2 nM and 2.6 nM, respectively. Mifepristone promotes cell autophagy and apoptosis, decreases Bcl-2 level and increases Beclin1 level, accompanied by weakened interaction between Bcl-2 and Beclin1.Mifepristone (RU486) can be used to induce animal models of Spontaneous Abortion.	Pharmacol Res, 2025, 215:107696 Cell Death Dis, 2025, 16(1):237 J Virol, 2025, 99(2):e0147224
E1091	Relacorilant (CORT125134)	Relacorilant (CORT125134) is a potent, selective and orally bioavailable glucocorticoid receptor antagonist, with a Ki of 7.2 nM in HepG2 TAT assay, and also shows Kis of 12, 81.2, 210 nM for rat, human and monkey glucocorticoid receptor in cell-based assay, respectively.	Biomed Pharmacother, 2024, 180:117523 J Endocrinol Invest, 2023, 10.1007/s40618-023-02184-3

Cat.No.

Product Name

Information

Product Use Citations

Product Validations

S6608

AL082D06

AL082D06 is a nonsteroidal glucocorticoid receptor (GR) antagonist with no detectable binding affinity for the highly related receptors for mineralocorticoids, androgens, estrogens, and progestins.

Int J Mol Sci, 2023, 24(14)11700

S2606

Mifepristone (RU-486)

Mifepristone is a remarkably active antagonist of progesterone receptor and glucocorticoid receptor with IC50 of 0.2 nM and 2.6 nM, respectively. Mifepristone promotes cell autophagy and apoptosis, decreases Bcl-2 level and increases Beclin1 level, accompanied by weakened interaction between Bcl-2 and Beclin1.Mifepristone (RU486) can be used to induce animal models of Spontaneous Abortion.

Pharmacol Res, 2025, 215:107696

Cell Death Dis, 2025, 16(1):237

J Virol, 2025, 99(2):e0147224

Verified customer review of Mifepristone (RU-486)

E1091

Relacorilant (CORT125134)

Relacorilant (CORT125134) is a potent, selective and orally bioavailable glucocorticoid receptor antagonist, with a Ki of 7.2 nM in HepG2 TAT assay, and also shows Kis of 12, 81.2, 210 nM for rat, human and monkey glucocorticoid receptor in cell-based assay, respectively.

Biomed Pharmacother, 2024, 180:117523

J Endocrinol Invest, 2023, 10.1007/s40618-023-02184-3