Cabazitaxel  Chemical Structure

Cabazitaxel Chemical Structure
Molecular Weight: 835.93

Validation & Quality Control

Quality Control & MSDS

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Cabazitaxel is available in the following compound libraries:

Product Information

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Product Description

Biological Activity

Description Cabazitaxel is a semi-synthetic derivative of a natural taxoid.
Targets Microtubule [1]
(Cell-free assay)
In vitro Cabazitaxel increases CYP3A enzyme activities in rat hepatocytes. The mean ex-vivo human plasma protein binding of Cabazitaxel is 91.6%. Cabazitaxel is rapidly and extensively metabolised in numerous metabolites. Cabazitaxel demonstrates activity in several murine and human resistant cell lines. [1] With a 4-day exposure to cabazitaxel, cytotoxicity is noted with relatively low cabazitaxel concentrations. Cabazitaxel shows high antitumor activity in 3 human colorectal cell lines (HCT-116, HCT-8, and HT-29). [2]
In vivo In accompanying models, Cabazitaxel is noted to have significant antitumor activity. In murine tumor xenografts (colon C38 and pancreas P03), Cabazitaxel elicites complete tumor regressions. Using SF-295 and U251 human glioblastoma cell lines, both orthotopic and subcutaneous murine xenografts are generated. Cabazitaxel treatment leads to complete regression in the majority of subcutaneously implanted tumors. Furthermore, in orthotopic models, Cabazitaxel leads to complete tumor regression in 4 out of 10 U251 tumors. [2]
Features A semi-synthetic derivative of a natural taxoid.

Protocol(Only for Reference)

Animal Study: [2]

Animal Models Murine tumor xenografts (colon C38 and pancreas P03)

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDog
Weight (kg)
Body Surface Area (m2)0.0070.0250.
Km factor36128520
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)


[1] EMEA/H/C/002018, 2011.

[2] Pal SK, et al. Clin Interv Aging, 2010, 5, 395-402.

Clinical Trial Information( data from, updated on 2015-11-14)

NCT Number Recruitment Conditions Sponsor
Start Date Phases
NCT02543255 Not yet recruiting Castration-resistant Prostate Cancer University Health Network, Toronto October 2016 Phase 2
NCT02485691 Recruiting Prostate Cancer Metastatic Sanofi October 2015 Phase 4
NCT02560337 Recruiting Ovarian Cancer Vejle Hospital September 2015 Phase 2
NCT02166658 Recruiting Breast Cancer|Lung Cancer|Recurrent Brain Metastases|Progressive Brain Metastases AIO-Studien-gGmbH|ClinAssess GmbH|Sanofi August 2015 Phase 2
NCT02512458 Recruiting Bone Metastatic Prostate Cancer Hellenic Cooperative Oncology Group|Sanofi July 2015 Phase 2

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Chemical Information

Download Cabazitaxel SDF
Molecular Weight (MW) 835.93


CAS No. 183133-96-2
Storage 3 years -20℃powder
6 months-80℃in solvent
Synonyms RPR-116258A, XRP6258, TXD 258
Solubility (25°C) * In vitro DMSO 100 mg/mL (119.62 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Name Benzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-

Product Use Citation (1)

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