Cabazitaxel

Catalog No.S3022

Cabazitaxel (XRP6258) is a semi-synthetic derivative of a natural taxoid.

Price Stock Quantity  
In DMSO USD 570 In stock
USD 170 In stock
USD 270 In stock
USD 1870 In stock
USD 2770 In stock
Bulk Inquiry

Massive Discount Available

Free Overnight Delivery on all orders over $ 500.

Cabazitaxel  Chemical Structure

Cabazitaxel Chemical Structure
Molecular Weight: 835.93

Validation & Quality Control

Quality Control & MSDS

Related Compound Libraries

Cabazitaxel is available in the following compound libraries:

Product Information

  • Compare Others
    Compare Others Products

Product Description

Biological Activity

Description Cabazitaxel (XRP6258) is a semi-synthetic derivative of a natural taxoid.
In vitro Cabazitaxel increases CYP3A enzyme activities in rat hepatocytes. The mean ex-vivo human plasma protein binding of Cabazitaxel is 91.6%. Cabazitaxel is rapidly and extensively metabolised in numerous metabolites. Cabazitaxel demonstrates activity in several murine and human resistant cell lines. [1] With a 4-day exposure to cabazitaxel, cytotoxicity is noted with relatively low cabazitaxel concentrations. Cabazitaxel shows high antitumor activity in 3 human colorectal cell lines (HCT-116, HCT-8, and HT-29). [2]
In vivo In accompanying models, Cabazitaxel is noted to have significant antitumor activity. In murine tumor xenografts (colon C38 and pancreas P03), Cabazitaxel elicites complete tumor regressions. Using SF-295 and U251 human glioblastoma cell lines, both orthotopic and subcutaneous murine xenografts are generated. Cabazitaxel treatment leads to complete regression in the majority of subcutaneously implanted tumors. Furthermore, in orthotopic models, Cabazitaxel leads to complete tumor regression in 4 out of 10 U251 tumors. [2]
Features A semi-synthetic derivative of a natural taxoid.

Protocol(Only for Reference)

Animal Study: [2]

Animal Models Murine tumor xenografts (colon C38 and pancreas P03)
Formulation
Dosages
Administration
Solubility 30% PEG400/0.5% Tween80/5% propylene glycol, , 30 mg/mL
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
1

References

[1] EMEA/H/C/002018, 2011.

[2] Pal SK, et al. Clin Interv Aging, 2010, 5, 395-402.

Chemical Information

Download Cabazitaxel SDF
Molecular Weight (MW) 835.93
Formula

C45H57NO14

CAS No. 183133-96-2
Storage 3 years -20℃Powder
6 months-80℃in DMSO
Synonyms
Solubility (25°C) * In vitro DMSO 100 mg/mL (119 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol, 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Name Benzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-

Research Area

Tech Support & FAQs

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

* Indicates a Required Field

Related Others Products

  • AZ191

    AZ191 is a potent and selective DYRK1B inhibitor with IC50 of 17 nM, about 5- and 110-fold selectivity over DYRK1A and DYRK2, respectively.

  • PTC-209

    PTC-209 is a potent and selective BMI-1 inhibitor with IC50 of 0.5 μM, and results in irreversible reduction of cancer-initiating cells (CICs).

  • AdipoRon

    AdipoRon is a novel, and orally bioavailable adiponectin receptor agonist with KD of 1.8 and 3.1 μM for AdipoR1 and AdipoR2, respectively.

  • Verapamil HCl

    Verapamil HCl is an L-type calcium channel blocker that is a class IV anti-arrhythmia agent.

  • CX-4945 (Silmitasertib)

    CX-4945 is a potent and selective inhibitor of CK2 (casein kinase 2) with IC50 of 1 nM, less potent to Flt3, Pim1 and CDK1 (inactive in cell-based assay). Phase 1.

    Features:First clinical inhibitor of CK2.

  • Tacrolimus (FK506)

    FK-506 is a 23-membered macrolide lactone, it reduces peptidyl-prolyl isomerase activity by binding to the immunophilin FKBP12 (FK506 binding protein) creating a new complex.

  • Verteporfin

    Verteporfin is a potent second-generation photosensitizing agent derived from porphyrin.

  • Cyclosporin A

    Cyclosporin A is an immunosuppressive agent, binds to the cyclophilin and then inhibits calcineurin with IC50 of 7 nM, widely used in organ transplantation to prevent rejection.

  • Chloroquine Phosphate

    Chloroquine phosphate is a 4-aminoquinoline anti-malarial and anti-rheumatoid agent.

  • Calcitriol

    Calcitriol is the hormonally active form of vitamin D.

Recently Viewed Items

Tags: buy Cabazitaxel | Cabazitaxel ic50 | Cabazitaxel price | Cabazitaxel cost | Cabazitaxel solubility dmso | Cabazitaxel purchase | Cabazitaxel manufacturer | Cabazitaxel research buy | Cabazitaxel order | Cabazitaxel mouse | Cabazitaxel chemical structure | Cabazitaxel mw | Cabazitaxel molecular weight | Cabazitaxel datasheet | Cabazitaxel supplier | Cabazitaxel in vitro | Cabazitaxel cell line | Cabazitaxel concentration | Cabazitaxel nmr
Contact Us