Cabazitaxel

Catalog No.S3022 Synonyms: RPR-116258A, XRP6258, TXD 258

Cabazitaxel  Chemical Structure

Molecular Weight(MW): 835.93

Cabazitaxel is a semi-synthetic derivative of a natural taxoid that kills cancer cells by inhibiting cell division and growth. Cabazitaxel exerts its effects by inhibiting microtubule growth and assembly, processes that are essential for cells to divide.

Size Price Stock Quantity  
In DMSO USD 570 In stock
USD 170 In stock
USD 270 In stock

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1 Customer Review

  • Urol Oncol, 2015, 33(9):385.e15-20.. Cabazitaxel purchased from Selleck.

Purity & Quality Control

Choose Selective Microtubule Associated Inhibitors

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Notes:

2. For more details, such as half maximal inhibitory concentrations (IC50s) and working concentrations of each inhibitor, please click on the link of the inhibitor of interest.
3. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
4. Orange "√" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

Biological Activity

Description Cabazitaxel is a semi-synthetic derivative of a natural taxoid that kills cancer cells by inhibiting cell division and growth. Cabazitaxel exerts its effects by inhibiting microtubule growth and assembly, processes that are essential for cells to divide.
Features A semi-synthetic derivative of a natural taxoid.
Targets
Microtubule [1]
(Cell-free assay)
In vitro

Cabazitaxel increases CYP3A enzyme activities in rat hepatocytes. The mean ex-vivo human plasma protein binding of Cabazitaxel is 91.6%. Cabazitaxel is rapidly and extensively metabolised in numerous metabolites. Cabazitaxel demonstrates activity in several murine and human resistant cell lines. [1] With a 4-day exposure to cabazitaxel, cytotoxicity is noted with relatively low cabazitaxel concentrations. Cabazitaxel shows high antitumor activity in 3 human colorectal cell lines (HCT-116, HCT-8, and HT-29). [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human MCF7 cells NX3yWJNwT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Ml76S5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gUWNHPyClZXzsd{BjgSCPVGSgZZN{[XluIFfJOVA:OS5zOTDuUS=> Ml;SNlQ1ODV5MEK=
human DU145 cells MkDMS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NEfxRZRIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBFXTF2NTDj[YxteyCkeTDNWHQh[XO|YYmsJGlEPTB;MT60N{BvVQ>? M{nxdFI1PDB3N{Cy
human A549 cells NED3e4ZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M{Tsd2dzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJGE2PDliY3XscJMh[nliTWTUJIF{e2G7LDDJR|UxRTFwNEigcm0> NX\vbIJiOjR2MEW3NFI>
human A431 cells MVrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M2\oUGdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJGE1OzFiY3XscJMh[nliTWTUJIF{e2G7LDDJR|UxRTFwNEigcm0> M1vPUVI1PDB3N{Cy
human HeLa cells M1qycmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MlG3S5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gTIVN[SClZXzsd{BjgSCPVGSgZZN{[XoxvJygTWM2OD1zLkigcm0> M{TE[FI1PDB3N{Cy
human K562 cells MlPES5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Mn\YS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gT|U3OiClZXzsd{BjgSCPVGSgZZN{[Xl? MXSyOFQxPTdyMh?=
human HL60 cells NEjW[HBIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Mn;BS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gTGw3OCClZXzsd{BjgSCPVGSgZZN{[Xl? MnjFNlQ1ODV5MEK=

... Click to View More Cell Line Experimental Data

In vivo In accompanying models, Cabazitaxel is noted to have significant antitumor activity. In murine tumor xenografts (colon C38 and pancreas P03), Cabazitaxel elicites complete tumor regressions. Using SF-295 and U251 human glioblastoma cell lines, both orthotopic and subcutaneous murine xenografts are generated. Cabazitaxel treatment leads to complete regression in the majority of subcutaneously implanted tumors. Furthermore, in orthotopic models, Cabazitaxel leads to complete tumor regression in 4 out of 10 U251 tumors. [2]

Protocol

Solubility (25°C)

In vitro DMSO 100 mg/mL (119.62 mM)
Water <1 mg/mL
Ethanol <1 mg/mL
In vivo

* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 835.93
Formula

C45H57NO14

CAS No. 183133-96-2
Storage powder
in solvent
Synonyms RPR-116258A, XRP6258, TXD 258

Bio Calculators

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02961257 Not yet recruiting Prostate Cancer Metastatic Association Pour La Recherche des Thérapeutiques Innovantes en Cancérologie March 2017 Phase 3
NCT03050866 Not yet recruiting Circulating Tumor Cell|Metastatic Prostate Cancer Erasmus Medical Center|Sanofi February 2017 Phase 2
NCT02903160 Not yet recruiting Prostate Cancer Icahn School of Medicine at Mount Sinai|Sanofi|Bayer October 2016 Phase 2
NCT02844582 Not yet recruiting Hormone-Resistant Prostate Cancer|Stage IV Prostate Adenocarcinoma University of California, Davis|Sanofi October 2016 Phase 2
NCT02543255 Recruiting Prostate Cancer University Health Network, Toronto September 2016 Phase 2
NCT02703623 Recruiting Prostate Cancer M.D. Anderson Cancer Center|Bristol-Myers Squibb|Janssen, LP|Sanofi May 2016 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Microtubule Associated Signaling Pathway Map

Related Microtubule Associated Products

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID