Cabazitaxel

Catalog No.S3022

Cabazitaxel (XRP6258) is a semi-synthetic derivative of a natural taxoid.

Price Stock Quantity  
In DMSO USD 570 In stock
USD 170 In stock
USD 270 In stock
USD 1870 In stock
USD 2770 In stock
Bulk Inquiry

Massive Discount Available

Free Overnight Delivery on all orders over $ 500.

Cabazitaxel  Chemical Structure

Cabazitaxel Chemical Structure
Molecular Weight: 835.93

Validation & Quality Control

Quality Control & MSDS

Related Compound Libraries

Cabazitaxel is available in the following compound libraries:

Product Information

  • Compare Others
    Compare Others

Product Description

Biological Activity

Description Cabazitaxel (XRP6258) is a semi-synthetic derivative of a natural taxoid.
Targets
IC50
In vitro Cabazitaxel increases CYP3A enzyme activities in rat hepatocytes. The mean ex-vivo human plasma protein binding of Cabazitaxel is 91.6%. Cabazitaxel is rapidly and extensively metabolised in numerous metabolites. Cabazitaxel demonstrates activity in several murine and human resistant cell lines. [1] With a 4-day exposure to cabazitaxel, cytotoxicity is noted with relatively low cabazitaxel concentrations. Cabazitaxel shows high antitumor activity in 3 human colorectal cell lines (HCT-116, HCT-8, and HT-29). [2]
In vivo In accompanying models, Cabazitaxel is noted to have significant antitumor activity. In murine tumor xenografts (colon C38 and pancreas P03), Cabazitaxel elicites complete tumor regressions. Using SF-295 and U251 human glioblastoma cell lines, both orthotopic and subcutaneous murine xenografts are generated. Cabazitaxel treatment leads to complete regression in the majority of subcutaneously implanted tumors. Furthermore, in orthotopic models, Cabazitaxel leads to complete tumor regression in 4 out of 10 U251 tumors. [2]
Features A semi-synthetic derivative of a natural taxoid.

Protocol(Only for Reference)

Animal Study: [2]

Animal Models Murine tumor xenografts (colon C38 and pancreas P03)
Dosages
Administration
Solubility 30% PEG400/0.5% Tween80/5% propylene glycol, 30 mg/mL
1

References

Chemical Information

Download Cabazitaxel SDF
Molecular Weight (MW) 835.93
Formula

C45H57NO14

CAS No. 183133-96-2
Storage 3 years -20℃Powder
6 months-80℃in DMSO
Syonnyms XRP-6258
Solubility (25°C) * In vitro DMSO 100 mg/mL (119 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol, 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Name Benzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-

Preparing Stock Solutions

Stock Solution (1ml DMSO) 1mM 10mM 20mM 30mM
Mass(mg) 0.83593 8.3593 16.7186 25.0779

Research Area

Tech Support & FAQs

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

* Indicates a Required Field

Related Others

  • SRPIN340

    SRPIN340 is a selective SRPK inhibitor with Ki of 0.89 μM for SRPK1, showing no significant inhibitory activity against more than 140 other kinases..

    Features:The only specific SRPK1 and SRPK2 inhibitor. Potential use in congenital diseases and viral diseases including HIV, HCV and HBV.

  • RI-1

    RI-1 is a RAD51 inhibitor with IC50 ranging from 5 to 30 μM.

    Features:A selective recombinant RAD51 protein inhibitor discovered in 2012. Valuable tool for mechanistic studies of DNA repair and potential for use in many cancers.

  • OAC1

    OAC1 (Oct4-activating compound 1) can enhance the efficiency of reprogramming.

  • CX-4945 (Silmitasertib)

    CX-4945 is a potent and selective inhibitor of CK2 (casein kinase 2) with IC50 of 1 nM, less potent to Flt3, Pim1 and CDK1 (inactive in cell-based assay). Phase 1.

    Features:First clinical inhibitor of CK2.

  • Tacrolimus (FK506)

    FK-506 is a 23-membered macrolide lactone, it reduces peptidyl-prolyl isomerase activity by binding to the immunophilin FKBP12 (FK506 binding protein) creating a new complex.

  • Bendamustine HCl

    Bendamustine HCL is a DNA-damaging agent with IC50 of 50 μM.

  • Posaconazole

    Posaconazole is a sterol C14ɑ demethylase inhibitor with an IC50 of 0.25 nM.

    Features:Currently the most advanced candidate for the treatment of Chagas disease.

  • Cidofovir

    Cidofovir suppresses virus replication by selective inhibition of viral DNA synthesis.

  • Simvastatin

    Simvastatin is a competitive inhibitor of HMG-CoA reductase with Ki of 0.1-0.2 nM .

  • Streptozotocin (STZ)

    Streptozotocin is a glucosamine-nitrosourea derivative, which is a methylating, carcinogenic, antibiotic and diabetes inducing agent.

Recently Viewed Items

Tags: buy Cabazitaxel | Cabazitaxel ic50 | Cabazitaxel price | Cabazitaxel cost | Cabazitaxel solubility dmso | Cabazitaxel purchase | Cabazitaxel manufacturer | Cabazitaxel research buy | Cabazitaxel order | Cabazitaxel mouse | Cabazitaxel chemical structure | Cabazitaxel mw | Cabazitaxel molecular weight | Cabazitaxel datasheet | Cabazitaxel supplier | Cabazitaxel in vitro | Cabazitaxel cell line | Cabazitaxel concentration | Cabazitaxel nmr
Contact Us