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PKC Inhibitors (11)


Cat.No. Product Name Information Product Use Citation Customer Product Validation
S1055 Enzastaurin (LY317615) Enzastaurin (LY317615) is a potent PKCβ selective inhibitor with IC50 of 6 nM in cell-free assays, 6- to 20-fold selectivity against PKCα, PKCγ and PKCε. Phase 3.
  • Oncogene, 2013, 32(9):1099-109
  • Oncogene, 2013, 32(34):3944-53
  • Mol Cancer Ther, 2015, 10.1158/1535-7163.MCT-14-0334
S2791 Sotrastaurin Sotrastaurin is a potent and selective pan-PKC inhibitor, mostly for PKCθ with Ki of 0.22 nM in a cell-free assay; inactive to PKCζ. Phase 2.
  • Cancer Cell, 2015, 27(3):397-408
  • Proc Natl Acad Sci USA, 2014, 111(15):E1528-37
  • Toxicol Sci, 2015, 145(1):59-67
S1421 Staurosporine Staurosporine is a potent PKC inhibitor for PKCα, PKCγ and PKCη with IC50 of 2 nM, 5 nM and 4 nM, less potent to PKCδ (20 nM), PKCε (73 nM) and little active to PKCζ (1086 nM) in cell-free assays. Also shows inhibitory activities on other kinases, such as PKA, PKG, S6K, CaMKII, etc. Phase 3.
  • Cancer Res, 2014, 74(23):7090-102
  • Am J Physiol Cell Physiol, 2013, 304(9):C895-904
  • PLoS One, 2012, 7(6):e39679
S2911 Go 6983 Go 6983 is a pan-PKC inhibitor against for PKCα, PKCβ, PKCγ and PKCδ with IC50 of 7 nM, 7 nM, 6 nM and 10 nM, respectively; less potent to PKCζ and inactive to PKCμ.
  • Mol Biol Cell, 2014, 25(11):1715-29
  • Cell Signal, 2014, 26(11):2436-2445
  • PLoS One, 2015, 10(4):e0122179
S7208 Bisindolylmaleimide I (GF109203X) GF109203X is a potent PKC inhibitor with IC50 of 20 nM, 17 nM, 16 nM, and 20 nM for PKCα, PKCβI, PKCβII, and PKCγ in cell-free assays, respectively, showing more than 3000-fold selectivity for PKC as compared to EGFR, PDGFR and insulin receptor.
  • Mol Cell Biochem, 2015, 400(1-2):213-22
  • J Oral Pathol Med, 2014, 10.1111/jop.12292
S8064 Midostaurin (PKC412) Midostaurin (pkc412) is a multi-targeted kinase inhibitor, including PKCα/β/γ, Syk, Flk-1, Akt, PKA, c-Kit, c-Fgr, c-Src, FLT3, PDFRβ and VEGFR1/2 with IC50 ranging from 80-500 nM.
S7207 Ro 31-8220 Mesylate Ro 31-8220 is a pan-PKC inhibitor with IC50 of 5 nM, 24 nM, 14 nM, 27 nM, and 24 nM for PKC-α, PKC-βI, PKC-βII, PKC-γ, and PKC-ε, respectively, and also shows potent inhibition against MAPKAP-K1b, MSK1, GSK3β and S6K1.
S4066 Dequalinium Chloride Dequalinium Chloride is a PKC inhibitor with IC50 of 7-18 μM, and also a selective blocker of apamin-sensitive K+ channels with IC50 of 1.1 μM.
S2327 Myricitrin Myricitrin, a flavonoid compound isolated from the root bark of Myrica cerifera, which exerts antinociceptive effects.
S2391 Quercetin Quercetin, a natural flavonoid present in vegetables, fruit and wine, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4-5.4 μM. Phase 4.
Cat.No. Product Name Information Product Use Citation Customer Product Validation
S7119 Go6976 Go6976 is a potent PKC inhibitor with IC50 of 7.9 nM, 2.3 nM, and 6.2 nM for PKC (Rat brain), PKCα, and PKCβ1, respectively. Also a potent inhibitor of JAK2 and Flt3.
  • Cell Signal, 2016, 28(9):1422-31
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All PKC Products

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Cat.No. Product Name Solubility (25°C)
Water DMSO Ethanol
S1055 Enzastaurin (LY317615) <1 mg/mL 30 mg/mL <1 mg/mL
S2791 Sotrastaurin <1 mg/mL 87 mg/mL 2 mg/mL
S1421 Staurosporine <1 mg/mL 4 mg/mL <1 mg/mL
S2911 Go 6983 <1 mg/mL 59 mg/mL <1 mg/mL
S7208 Bisindolylmaleimide I (GF109203X) <1 mg/mL 82 mg/mL <1 mg/mL
S8064 Midostaurin (PKC412) <1 mg/mL 100 mg/mL 100 mg/mL
S7207 Ro 31-8220 Mesylate <1 mg/mL 100 mg/mL <1 mg/mL
S4066 Dequalinium Chloride <1 mg/mL 0.025 mg/mL <1 mg/mL
S2327 Myricitrin <1 mg/mL 93 mg/mL 1 mg/mL
S2391 Quercetin <1 mg/mL 61 mg/mL 10 mg/mL
S7119 Go6976 <1 mg/mL 18 mg/mL <1 mg/mL
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