Research Area
Product Type
United States ( Change Country )
CYT997 Chemical Structure
Docetaxel (Taxotere)
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Paclitaxel (Taxol)
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ABT-751
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Vincristine
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Epothilone A
Epothilone A is a new kind of microtubule function inhibitor with an IC50 of 4.4 nM for tubulin polymerization and cytotoxicity.
Epothilone B (EPO906)
Epothilone B (EPO906) is a new kind of cancer agents and microtubule function inhibitor with an IC50 of 3.5 nM.
Vinflunine Tartrate
Vinflunine Tartrate is a tartrate salt of vinflunine that is a new microtubule inhibitor agent with IC50 of 18.8 nM.
ABT-888 (Veliparib)
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Olaparib (AZD2281)
Olaparib(AZD2281, KU0059436) is a selective inhibitor of PARP-1 and PARP-2 enzymes with IC50 of 5 nM and 1 nM, respectively.
Y-27632 2HCl
Y-27632 2HCl is ROCK inhibitor, as a novel bronchodilator. Y27632 is available with IC50 of 3.3±0.25 μM and 2.8±0.2 μM in human and rabbit tissues, respectively.
Biological Activity
CYT997, a synthetic small molecule optimized for antiproliferative activity in a panel of cell-based assays, in which the compound shows an IC50 of between 1 and 100 nmol/L across a panel of cancer cell lines. The compound inhibits the polymerization of tubulin with an IC50 of ～3 μmol/L.CYT997 causes a significant increase of cells in the G2-M phase of the cell cycle.Caspase-3 activation is also observed in cells treated with CYT997 along with the generation of poly(ADP-ribose) polymerase.CYT997 exhibits vascular disrupting activity as measured in vitro by effects on the permeability of human umbilical vein endothelial cell monolayers, and in vivo by effects on tumor blood flow. CYT997 possesses a useful combination of pharmacologic and pharmacokinetic properties and has considerable potential as a novel anticancer agent. [1]
References on CYT997
- [1] Mol Cancer Ther 2009;8:3036-3045
Product Information
| Molecular Weight (WM): | 434.53 |
|---|---|
| Formula: | C24H30N6O2 |
| CAS No.: | 917111-44-5 |
| Synonyms: |
N/A
|
| Dissolve in (25°C): | DMSO ≥87mg/mL |
| Water <1mg/mL | |
| Ethanol ≥20mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
Quality Control & MSDS
Research Area
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