Microtubule Associated

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Microtubule Associated Inhibitors (23)

water-soluble

Cat.No. Product Name Information Product Use Citation Customer Product Validation
S1150 Paclitaxel Paclitaxel is a microtubule polymer stabilizer with IC50 of 0.1 pM in human endothelial cells.
  • ACS Appl Mater Interfaces, 2015, 10.1021/am5090226
  • Biomacromolecules, 2014, 15(11):4187-94
  • Biochem Pharmacol, 2015, 10.1016/j.bcp.2015.05.005
S1148 Docetaxel Docetaxel, an analog of paclitaxel, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules.
  • Int J Cancer, 2015, 136(9):2065-77
  • Biochem Pharmacol, 2015, 10.1016/j.bcp.2015.05.005
  • Mol Pharm, 2014, 11(7):2040-50
S1241 Vincristine Vincristine is an inhibitor of polymerization of microtubules by binding to tubulin with IC50 of 32 μM in a cell-free assay.
  • Cancer Res, 2013, 73(20):6310-22
  • J Pharmacol Exp Ther, 2014, 350(3):646-56
  • Int J Mol Sci, 2012, 13(9):10736-49
S1364 Epothilone B (EPO906, Patupilone) Epothilone B (EPO906, Patupilone) is a paclitaxel-like microtubule-stabilizing agent with EC0.01 of 1.8 μM. Phase 2.
S1165 ABT-751 (E7010) ABT-751 (E7010) binds to the colchicine site on β-tubulin and inhibits polymerization of microtubules, not a substrate for the MDR transporter and is active against cell lines resistant to vincristine, doxorubicin, and cisplatin. Phase 1/2.
  • Bioorg Med Chem, 2013, 21(4):922-31
S7783 Combretastatin A4 Combretastatin A4 is a microtubule-targeting agent that binds β-tubulin with Kd of 0.4 μM.Phase 3.
S7787 Docetaxel Trihydrate Docetaxel, an analog of paclitaxel, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules.
  • Int J Cancer, 2015, 136(9):2065-77
  • Biochem Pharmacol, 2015, 10.1016/j.bcp.2015.05.005
  • Mol Pharm, 2014, 11(7):2040-50
S7495 TAI-1 TAI-1 is a potent and specific Hec1 inhibitor, which disrupts Hec1-Nek2 protein interaction.
S7494 INH6 INH6 is a potent Hec1 inhibitor, which specifically disrupts the Hec1/Nek2 interaction and causes chromosome mis-alignment.
S7493 INH1 INH1 is a cell-permeable Hec1 inhibitor, which specifically disrupts the Hec1/Nek2 interaction.
S2775 Nocodazole Nocodazole is a rapidly-reversible inhibitor of microtubule polymerization, also inhibits Abl, Abl(E255K) and Abl(T315I) with IC50 of 0.21 μM, 0.53 μM and 0.64 μM in cell-free assays, respectively.
  • J Immunol, 2015, 10.4049/jimmunol.1402897
S3022 Cabazitaxel Cabazitaxel is a semi-synthetic derivative of a natural taxoid.
S4269 Vinorelbine Tartrate Vinorelbine Tartrate is a semi-synthetic vinca alkaloid, and inhibits mitosis through interaction with tubulin.
  • PLoS One, 2015, 10(4):e0123901
S7497 CK-636 CK-636 is an Arp2/3 complex inhibitor with IC50 of 4 μM, 24 μM and 32 μM for inhibition of actin polymerization induced by human, fission yeast and bovine Arp2/3 complex, respectively.
S7204 Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium is the water-soluble prodrug of Combretastatin A4 (CA4), which is a microtubule-targeting agent that binds β-tubulin with Kd of 0.4 μM in a cell-free assay. Fosbretabulin
S7336 CW069 CW069 is an allosteric, and selective inhibitor of microtubule motor protein HSET with IC50 of 75 μM, significant selectivity over KSP.
S1297 Epothilone A Epothilone A is a paclitaxel-like microtubule-stabilizing agent with EC0.01 of 2 μM.
S1640 Albendazole Albendazole is a member of the benzimidazole compounds used as a drug indicated for the treatment of a variety of worm infestations.
S1248 Vinblastine Vinblastine inhibits microtubule formation and suppresses nAChR activity with IC50 of 8.9 μM in a cell-free assay, used to treat certain kinds of cancer.
S2195 CYT997 (Lexibulin) CYT997 (Lexibulin) is a potent microtubule polymerization inhibitor with IC50 of 10-100 nM in cancer cell lines. Phase 2.
  • Exp Ther Med, 2013, 6(2):299-304
S4071 Griseofulvin Griseofulvin, a production from some strains of the mold Penicillium griseofulvumam, is able to inhibit cell mitosis by interfering with microtubule function.
S4114 Triclabendazole Triclabendazole is a benzimidazole, it binds to tubulin impairing intracellular transport mechanisms and interferes with protein synthesis.
S2209 Vinflunine Tartrate Vinflunine is a new vinca alkaloid uniquely fluorinated with the properties of mitotic-arresting and tubulin-interacting activity. Phase 3.

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Cat.No. Product Name Solubility (25°C)
Water DMSO Ethanol
S1150 Paclitaxel <1 mg/mL 171 mg/mL 18 mg/mL
S1148 Docetaxel <1 mg/mL 100 mg/mL 53 mg/mL
S1241 Vincristine 60 mg/mL 100 mg/mL <1 mg/mL
S1364 Epothilone B (EPO906, Patupilone) <1 mg/mL 102 mg/mL 102 mg/mL
S1165 ABT-751 (E7010) <1 mg/mL 74 mg/mL 12 mg/mL
S7783 Combretastatin A4 <1 mg/mL 63 mg/mL 34 mg/mL
S7787 Docetaxel Trihydrate <1 mg/mL 100 mg/mL 100 mg/mL
S7495 TAI-1 <1 mg/mL 86 mg/mL <1 mg/mL
S7494 INH6 <1 mg/mL 64 mg/mL 11 mg/mL
S7493 INH1 <1 mg/mL 61 mg/mL 61 mg/mL
S2775 Nocodazole <1 mg/mL 7 mg/mL <1 mg/mL
S3022 Cabazitaxel <1 mg/mL 100 mg/mL <1 mg/mL
S4269 Vinorelbine Tartrate 100 mg/mL 100 mg/mL 100 mg/mL
S7497 CK-636 <1 mg/mL 57 mg/mL 50 mg/mL
S7204 Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium 28 mg/mL <1 mg/mL <1 mg/mL
S7336 CW069 <1 mg/mL 100 mg/mL 4 mg/mL
S1297 Epothilone A <1 mg/mL 99 mg/mL 99 mg/mL
S1640 Albendazole <1 mg/mL 17 mg/mL <1 mg/mL
S1248 Vinblastine <1 mg/mL 68 mg/mL 6 mg/mL
S2195 CYT997 (Lexibulin) <1 mg/mL 86 mg/mL 20 mg/mL
S4071 Griseofulvin <1 mg/mL 50 mg/mL <1 mg/mL
S4114 Triclabendazole <1 mg/mL 72 mg/mL <1 mg/mL
S2209 Vinflunine Tartrate 100 mg/mL 100 mg/mL 47 mg/mL
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