Microtubule Associated

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Microtubule Associated Inhibitors (23)

water-soluble

Cat.No. Product Name Information Product Use Citation Customer Product Validation
S1150 Paclitaxel Paclitaxel is a microtubule polymer stabilizer with IC50 of 0.1 pM in human endothelial cells.
  • ACS Appl Mater Interfaces, 2015, 10.1021/am5090226
  • Biomacromolecules, 2014, 15(11):4187-94
  • Biochem Pharmacol, 2015, 10.1016/j.bcp.2015.05.005
S1148 Docetaxel Docetaxel, an analog of paclitaxel, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules.
  • Int J Cancer, 2015, 136(9):2065-77
  • Biochem Pharmacol, 2015, 10.1016/j.bcp.2015.05.005
  • Mol Pharm, 2014, 11(7):2040-50
S1241 Vincristine Vincristine is an inhibitor of polymerization of microtubules by binding to tubulin with IC50 of 32 μM in a cell-free assay.
  • Cancer Res, 2013, 73(20):6310-22
  • J Pharmacol Exp Ther, 2014, 350(3):646-56
  • Int J Mol Sci, 2012, 13(9):10736-49
S1364 Epothilone B (EPO906, Patupilone) Epothilone B (EPO906, Patupilone) is a paclitaxel-like microtubule-stabilizing agent with EC0.01 of 1.8 μM. Phase 2.
S1165 ABT-751 (E7010) ABT-751 (E7010) binds to the colchicine site on β-tubulin and inhibits polymerization of microtubules, not a substrate for the MDR transporter and is active against cell lines resistant to vincristine, doxorubicin, and cisplatin. Phase 1/2.
  • Bioorg Med Chem, 2013, 21(4):922-31
S7783 Combretastatin A4 Combretastatin A4 is a microtubule-targeting agent that binds β-tubulin with Kd of 0.4 μM.Phase 3.
S7787 Docetaxel Trihydrate Docetaxel, an analog of paclitaxel, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules.
  • Int J Cancer, 2015, 136(9):2065-77
  • Biochem Pharmacol, 2015, 10.1016/j.bcp.2015.05.005
  • Mol Pharm, 2014, 11(7):2040-50
S7495 TAI-1 TAI-1 is a potent and specific Hec1 inhibitor, which disrupts Hec1-Nek2 protein interaction.
S2775 Nocodazole Nocodazole is a rapidly-reversible inhibitor of microtubule polymerization, also inhibits Abl, Abl(E255K) and Abl(T315I) with IC50 of 0.21 μM, 0.53 μM and 0.64 μM in cell-free assays, respectively.
  • J Immunol, 2015, 10.4049/jimmunol.1402897
S3022 Cabazitaxel Cabazitaxel is a semi-synthetic derivative of a natural taxoid.
S7494 INH6 INH6 is a potent Hec1 inhibitor, which specifically disrupts the Hec1/Nek2 interaction and causes chromosome mis-alignment.
S7493 INH1 INH1 is a cell-permeable Hec1 inhibitor, which specifically disrupts the Hec1/Nek2 interaction.
S4269 Vinorelbine Tartrate Vinorelbine Tartrate is a semi-synthetic vinca alkaloid, and inhibits mitosis through interaction with tubulin.
  • PLoS One, 2015, 10(4):e0123901
S7497 CK-636 CK-636 is an Arp2/3 complex inhibitor with IC50 of 4 μM, 24 μM and 32 μM for inhibition of actin polymerization induced by human, fission yeast and bovine Arp2/3 complex, respectively.
S7204 Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium is the water-soluble prodrug of Combretastatin A4 (CA4), which is a microtubule-targeting agent that binds β-tubulin with Kd of 0.4 μM in a cell-free assay. Fosbretabulin Disodium inhibits the polymerization of tubulin with IC50 of 2.4 μM, and also disrupts tumor vasculature. Phase 3.
S7336 CW069 CW069 is an allosteric, and selective inhibitor of microtubule motor protein HSET with IC50 of 75 μM, significant selectivity over KSP.
S1297 Epothilone A Epothilone A is a paclitaxel-like microtubule-stabilizing agent with EC0.01 of 2 μM.
S1640 Albendazole Albendazole is a member of the benzimidazole compounds used as a drug indicated for the treatment of a variety of worm infestations.
S1248 Vinblastine Vinblastine inhibits microtubule formation and suppresses nAChR activity with IC50 of 8.9 μM in a cell-free assay, used to treat certain kinds of cancer.
S2195 CYT997 (Lexibulin) CYT997 (Lexibulin) is a potent microtubule polymerization inhibitor with IC50 of 10-100 nM in cancer cell lines. Phase 2.
  • Exp Ther Med, 2013, 6(2):299-304
S4071 Griseofulvin Griseofulvin, a production from some strains of the mold Penicillium griseofulvumam, is able to inhibit cell mitosis by interfering with microtubule function.
S4114 Triclabendazole Triclabendazole is a benzimidazole, it binds to tubulin impairing intracellular transport mechanisms and interferes with protein synthesis.
S2209 Vinflunine Tartrate Vinflunine is a new vinca alkaloid uniquely fluorinated with the properties of mitotic-arresting and tubulin-interacting activity. Phase 3.

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Cat.No. Product Name Solubility (25°C)
Water DMSO Ethanol
S1150 Paclitaxel <1 mg/mL 171 mg/mL 18 mg/mL
S1148 Docetaxel <1 mg/mL 100 mg/mL 53 mg/mL
S1241 Vincristine 60 mg/mL 100 mg/mL <1 mg/mL
S1364 Epothilone B (EPO906, Patupilone) <1 mg/mL 102 mg/mL 102 mg/mL
S1165 ABT-751 (E7010) <1 mg/mL 74 mg/mL 12 mg/mL
S7783 Combretastatin A4 <1 mg/mL 63 mg/mL 34 mg/mL
S7787 Docetaxel Trihydrate <1 mg/mL 100 mg/mL 100 mg/mL
S7495 TAI-1 <1 mg/mL 86 mg/mL <1 mg/mL
S2775 Nocodazole <1 mg/mL 7 mg/mL <1 mg/mL
S3022 Cabazitaxel <1 mg/mL 100 mg/mL <1 mg/mL
S7494 INH6 <1 mg/mL 64 mg/mL 11 mg/mL
S7493 INH1 <1 mg/mL 61 mg/mL 61 mg/mL
S4269 Vinorelbine Tartrate 100 mg/mL 100 mg/mL 100 mg/mL
S7497 CK-636 <1 mg/mL 57 mg/mL 50 mg/mL
S7204 Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium 28 mg/mL <1 mg/mL <1 mg/mL
S7336 CW069 <1 mg/mL 100 mg/mL 4 mg/mL
S1297 Epothilone A <1 mg/mL 99 mg/mL 99 mg/mL
S1640 Albendazole <1 mg/mL 17 mg/mL <1 mg/mL
S1248 Vinblastine <1 mg/mL 68 mg/mL 6 mg/mL
S2195 CYT997 (Lexibulin) <1 mg/mL 86 mg/mL 20 mg/mL
S4071 Griseofulvin <1 mg/mL 50 mg/mL <1 mg/mL
S4114 Triclabendazole <1 mg/mL 72 mg/mL <1 mg/mL
S2209 Vinflunine Tartrate 100 mg/mL 100 mg/mL 47 mg/mL
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