Microtubule

Cat.No. Product Name Feedback Added

S1165

ABT-751

Mar 2010
ABT-751 is a novel bioavailable tubulin-binding and antimitotic sulfonamide agent with IC50 of about 1.5 and 3.4 µM in neuroblastoma and non-neuroblastoma cell lines, respectively.
S2195

CYT997

Feb 2011
CYT997, a small molecule inhibits the polymerization of tubulin with an IC50 of 3 μmol/L and shows an IC50 of between 1 and 100 nmol/L across a panel of cancer cell lines.
S1148

Docetaxel (Taxotere)

Feb 2010
Docetaxel (Taxotere) is an microtubule disassembly inhibitor with IC50 of a range of 0.31–100 ηM.
S1297

Epothilone A

Jun 2010
Epothilone A is a new kind of microtubule function inhibitor with an IC50 of 4.4 nM for tubulin polymerization and cytotoxicity.
S1364

Epothilone B

Jun 2010
Epothilone B is a new kind of cancer agents and microtubule function inhibitor with an IC50 of 3.5 nM.
S1150

Paclitaxel (Taxol)

Feb 2010
Paclitaxel also known as Taxol, Onxol, Nov-Onxol is a microtubule polymer stabilizer with an IC50 of 0.1 pM for human endothelial cells.
S1241

Vincristine Sulfate

May 2010
Vincristine Sulfate is a microtubule function inhibitor with IC50 of 10.4±1.1, 28.1±3.4, 22.4±2.1 µM for HL-60, Bel7402, HO-8910, respectively.
S2209

Vinflunine Tartrate

Mar 2011
Vinflunine Tartrate is a tartrate salt of vinflunine that is a new microtubule inhibitor agent with IC50 of 18.8 nM.
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Customer's Feedback
Arnaud AUTRET, Trinity College
"I would like to confirm you that everything is perfectly fine with ABT and Obatoclax we got from your company. We confirmed their activity in vitro. We notably observed their impact in an apoptotic model and results are similar to those which have been published."

Dongfeng Chen, The Rausing Lab
"Your product U0126(Cat.NO S1102) works well in our experiments. I hope I can get more excellent products from your company in future."

Dr. Alexandra Segref, CECAD Cologne,Germay
"I am very satisfied with your product and costumer service. Bortezomib works very well in our assay, it is comparably cheaper than other inhibitors that we tested is more reliable for our assays. We see a great effect by using 10nM concentration."

R.B. Cambridge
"I have used the chemical that I bought from you(Selleck,PTC-124) and it worked well.So we will eventually be ordering more."

Zhenghe John Wang Assistant Professor, Case Western Reserve University
"We have purchased LBH-589, Saha and MS-275 from you and they all worked well."

Jenny Sun
"We used the LBH-589 in our experiments. The compound is easy to use with excellent reproducibility."

Yu Wang, Harvard University
"The GDC0449 compound worked very well. The results in my hands are equally good as what's been published. Thanks for this great resource for our research."

Philip Seeman, Toronto University
"Your LY404039 compound was well synthesized, its complicated stereochemical structure confirmed by NMR spectroscopy, and was biologically excellent in acting on brain dopamine receptors."

Dung-Fang Lee
"Based on our preliminary data, I found MLN8237 and VX-680 have good effects in inhibiting Aurka-maintaining ESC self-renewal in mouse ES cells."

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