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Microtubule Associated Inhibitors

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Cat.No. Product Name Information Product Use Citations Product Validations
E1068 Nab-Paclitaxel Nab-Paclitaxel is a novel solvent-free paclitaxel in which the binding ratio of paclitaxel to human albumin is approximately 1:9. It is an anti-microtubule drug that promotes microtubule aggregation in tubulin dimers and inhibits microtubule depolymerization to stabilize the microtubule system. Solutions are unstable and should be fresh-prepared.
Mol Ther, 2025, 33(12):6160-6177
J Nanobiotechnology, 2025, 23(1):691
Br J Cancer, 2025, 10.1038/s41416-025-03185-0
S1148 Docetaxel Docetaxel, an analog of paclitaxel, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules.
Cancer Discov, 2025, 10.1158/2159-8290.CD-25-0629
Drug Resist Updat, 2025, 84:101313
Adv Sci (Weinh), 2025, 12(10):e2413174
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S2775 Nocodazole Nocodazole is a rapidly-reversible inhibitor of microtubule polymerization, also inhibits Abl, Abl(E255K) and Abl(T315I) with IC50 of 0.21 μM, 0.53 μM and 0.64 μM in cell-free assays, respectively. Nocodazole induces apoptosis.
Adv Mater, 2025, e17493.
Nat Commun, 2025, 16(1):7898
EMBO J, 2025, 44(22):6556-6597
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S0328 MMAF Monomethylauristatin F (MMAF) is a synthetic antineoplastic agent and a potent inhibitor of tubulin polymerization. This compound is applied as a cytotoxic component of antibody-drug conjugates (ADCs) such as vorsetuzumab mafodotin, ABT-414 and SGN-CD19A.
Cancer Cell, 2021, S1535-6108(21)00659-0
S1150 Paclitaxel Paclitaxel is a microtubule polymer stabilizer with IC50 of 0.1 pM in human endothelial cells.Paclitaxel can cause both mitotic arrest and apoptotic cell death. Paclitaxel also induces autophagy.
Nature, 2025, 10.1038/s41586-025-08974-4
Cell, 2025, S0092-8674(25)00386-1
Cell Res, 2025, 35(6):437-452.
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S1241 Vincristine (Leurocristine) Sulfate Vincristine sulfate is an inhibitor of polymerization of microtubules by binding to tubulin with IC50 of 32 μM in a cell-free assay. Vincristine sulfate induces apoptosis.
Signal Transduct Target Ther, 2025, 10(1):230
Leukemia, 2025, 39(12):2881-2894
Cell Rep, 2025, 44(4):115434
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S7721 MMAE (Monomethyl auristatin E) MMAE (Monomethyl auristatin E) is a synthetic antineoplastic agent. It is also a microtubule-disrupting agent .
Front Immunol, 2024, 15:1393485
Leuk Lymphoma, 2023, 1-11.
Br J Haematol, 2022, 10.1111/bjh.18341
S9555 Vincristine Vincristine (Leurocristine, NSC-67574, 22-Oxovincaleukoblastine) is a natural alkaloid isolated from the plant Vinca rosea Linn. with anti-tumor activity. This compound inhibits microtubule formation in mitotic spindle and binds to microtubule with Ki of 85 nM.
Nat Commun, 2025, 16(1):4133
Cell Rep Med, 2025, S2666-3791(25)00102-8
Proc Natl Acad Sci U S A, 2025, 122(28):e2507203122
S7787 Docetaxel Trihydrate Docetaxel (RP56976, NSC 628503), an analog of paclitaxel, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules.
iScience, 2024, 27(10):110862
PLoS Biol, 2023, 21(4):e3002038
Mol Cancer, 2022, 21(1):150
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S4269 Vinorelbine ditartrate Vinorelbine ditartrate is a semi-synthetic vinca alkaloid, and inhibits mitosis through interaction with tubulin. Vinorelbine Tartrate exhibits anti-tumor activities via inducing the mitotic apoptosis, autophagy and inflammation.
Commun Biol, 2025, 8(1):152
Sci Rep, 2025, 15(1):11372
Cell Death Dis, 2024, 15(8):603
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