Choose Your Country or Region

Microtubule Associated

Microtubule Associated Products

All (84)
Microtubule Associated Inhibitors (60)
Microtubule Associated Antibodies (3)
Microtubule Associated Modulators (4)
New Microtubule Associated Products

Catalog No.	Product Name	Information	Product Use Citations
S1150	Paclitaxel	Paclitaxel is a microtubule polymer stabilizer with IC50 of 0.1 pM in human endothelial cells.Paclitaxel can cause both mitotic arrest and apoptotic cell death. Paclitaxel also induces autophagy.	Nature, 2025, 10.1038/s41586-025-08974-4 Cell, 2025, S0092-8674(25)00386-1 Cell Res, 2025, 35(6):437-452.
S1148	Docetaxel	Docetaxel, an analog of paclitaxel, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules.	Adv Sci (Weinh), 2025, 12(10):e2413174 Adv Sci (Weinh), 2025, 12(10):e2411769 Commun Biol, 2025, 8(1):152
S1241	Vincristine sulfate	Vincristine sulfate is an inhibitor of polymerization of microtubules by binding to tubulin with IC50 of 32 μM in a cell-free assay. Vincristine sulfate induces apoptosis.	Cell Rep, 2025, 44(4):115434 J Transl Med, 2025, 23(1):542 J Biol Chem, 2025, S0021-9258(25)00076-6
S2775	Nocodazole	Nocodazole is a rapidly-reversible inhibitor of microtubule polymerization, also inhibits Abl, Abl(E255K) and Abl(T315I) with IC50 of 0.21 μM, 0.53 μM and 0.64 μM in cell-free assays, respectively. Nocodazole induces apoptosis.	Clin Transl Med, 2025, 15(1):e70164 Cancer Res Commun, 2025, 5(4):648-667 Signal Transduct Target Ther, 2024, 9(1):181.
S1233	2-Methoxyestradiol (2-MeOE2)	2-Methoxyestradiol (2-MeOE2, NSC 659853, 2-ME2) depolymerizes microtubules and blocks HIF-1α nuclear accumulation and HIF-transcriptional activity. 2-Methoxyestradiol induces both autophagy and apoptosis in various carcinogenic cell lines.	Nat Commun, 2025, 16(1):4681 Int J Nanomedicine, 2025, 20:933-950 Theranostics, 2024, 14(13):5123-5140
S7787	Docetaxel Trihydrate	Docetaxel (RP56976, NSC 628503), an analog of paclitaxel, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules.	iScience, 2024, 27(10):110862 PLoS Biol, 2023, 21(4):e3002038 Mol Cancer, 2022, 21(1):150
S4505	Vinblastine sulfate	Vinblastine sulfate inhibits microtubule formation and suppresses nAChR activity with IC50 of 8.9 μM in a cell-free assay, used to treat certain kinds of cancer. Vinblastine sulfate induces autophagy and apoptosis.	Int J Mol Sci, 2025, 26(8)3864 Anticancer Res, 2025, 45(1):39-53 iScience, 2024, 27(10):110862
S4269	Vinorelbine ditartrate	Vinorelbine ditartrate is a semi-synthetic vinca alkaloid, and inhibits mitosis through interaction with tubulin. Vinorelbine Tartrate exhibits anti-tumor activities via inducing the mitotic apoptosis, autophagy and inflammation.	Commun Biol, 2025, 8(1):152 Sci Rep, 2025, 15(1):11372 Cell Death Dis, 2024, 15(8):603
S3022	Cabazitaxel	Cabazitaxel is a semi-synthetic derivative of a natural taxoid that kills cancer cells by inhibiting cell division and growth. Cabazitaxel exerts its effects by inhibiting microtubule growth and assembly, processes that are essential for cells to divide. Cabazitaxel induces autophagy via the PI3K/Akt/mTOR pathway.	J Photochem Photobiol B, 2024, 253:112877 Cancer Biol Ther, 2024, 25(1):2329368 Oncol Lett, 2024, 28(6):605
S2284	Colchicine	Colchicine is a microtubule polymerization inhibitor with an IC50 of 3 nM.	Int J Mol Sci, 2025, 26(8)3864 Eur J Pharmacol, 2024, 983:176968 Biomedicines, 2024, 12(2)406
S1364	Patupilone (Epothilone B)	Patupilone (EPO906, Epothilone B) is a microtubule-stabilizing agent with EC_0.01 of 1.8 μM. Phase 2.	Brain Commun, 2023, 5(1):fcad005 Brain, 2022, awac079 Genome Med, 2021, 13(1):189
S7930	Ixabepilone	Ixabepilone is an orally bioavailable microtubule inhibitor. It binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arresting cells in the G2-M phase of the cell cycle and inducing tumor cell apoptosis.	J Pers Med, 2022, 12(2)258 Pharmacol Rep, 2022, 10.1007/s43440-022-00396-7 Hum Cell, 2022, 10.1007/s13577-022-00671-y
S7204	Fosbretabulin (Combretastatin A4 Phosphate) Disodium	Fosbretabulin (Combretastatin A4 Phosphate) Disodium is the water-soluble prodrug of Combretastatin A4 (CA4), which is a microtubule-targeting agent that binds β-tubulin with K_d of 0.4 μM in a cell-free assay. Fosbretabulin Disodium inhibits the polymerization of tubulin with IC50 of 2.4 μM, and also disrupts tumor vasculature. Fosbretabulin disodium induces mitotic arrest and apoptosis in endothelial cells. Phase 3.	Front Oncol, 2023, 13:1249524 Front Oncol, 2023, 13:1249524 Cell, 2020, 182(3):685-712.e19
S2195	Lexibulin (CYT997)	Lexibulin (CYT997, SRI-32007) is a potent microtubule polymerization inhibitor with IC50 of 10-100 nM in cancer cell lines. Phase 2.	Cell, 2021, 184(2):334-351.e20 Adv Virol, 2020, 2020:8844061 J Exp Clin Cancer Res, 2019, 38(1):44
S1640	Albendazole	Albendazole is a member of the benzimidazole compounds used as a drug indicated for the treatment of a variety of worm infestations.	Sci Rep, 2022, 12(1):5706 Mol Cell, 2021, 81(19):4041-4058.e15 Cancer Lett, 2021, 520:307-320
S7336	CW069	CW069 is an allosteric, and selective inhibitor of microtubule motor protein HSET with IC50 of 75 μM, significant selectivity over KSP.	Nat Commun, 2023, 14(1):6505 Nat Commun, 2023, 14(1):6505 Life Sci Alliance, 2022, 5(11)e202201470
S7721	MMAE (Monomethyl auristatin E)	MMAE (Monomethyl auristatin E) is a synthetic antineoplastic agent. It is also a microtubule-disrupting agent .	Front Immunol, 2024, 15:1393485 Leuk Lymphoma, 2023, 1-11. Br J Haematol, 2022, 10.1111/bjh.18341
S1165	ABT-751 (E7010)	ABT-751 (E7010) binds to the colchicine site on β-tubulin and inhibits polymerization of microtubules, not a substrate for the MDR transporter and is active against cell lines resistant to vincristine, doxorubicin, and cisplatin. Phase 1/2.	J Clin Invest, 2020, 10.1172/JCI122462 Fitoterapia, 2017, 116:106-115 PLoS Genet, 2016, 12(9):e1006279
S1176	Plinabulin	Plinabulin is a vascular disrupting agent (VDA) against tubulin-depolymerizing with IC50 of 9.8~18 nM in tumor cells. Phase 1/2.	J Med Chem, 2022, 65(13):9159-9173 ACS Omega, 2022, 7(25):21465-21472 J Biol Chem, 2019, 294(20):8161-8170
S7783	Combretastatin A4	Combretastatin A4 is a microtubule-targeting agent that binds β-tubulin with K_d of 0.4 μM.Phase 3.	EMBO Mol Med, 2025, 10.1038/s44321-025-00222-6 Mol Cell, 2023, 83(13):2290-2302.e13 Mol Cell, 2023, 83(13):2290-2302.e13
S7497	CK-636	CK-636 (CK-0944636) is an Arp2/3 complex inhibitor with IC50 of 4 μM, 24 μM and 32 μM for inhibition of actin polymerization induced by human, fission yeast and bovine Arp2/3 complex, respectively.	J Biol Chem, 2024, 300(12):107942 Elife, 2021, 10e65910 Theranostics, 2019, 9(25):7628-7647
S1297	Epothilone A	Epothilone A is a paclitaxel-like microtubule-stabilizing agent with EC_0.01 of 2 μM.	Environ Mol Mutagen, 2024, 10.1002/em.22604 Environ Mol Mutagen, 2022, 63(3):151-161 Cancers (Basel), 2020, 12(12)E3816
S7495	TAI-1	TAI-1 is a potent and specific Hec1 inhibitor, which disrupts Hec1-Nek2 protein interaction.	J Exp Clin Cancer Res, 2019, 18;38(1):316 Curr Biol, 2019, 29(18):3072-3080.e5 Curr Biol, 2019, 29(18):3072-3080
S0360	EGFR Inhibitor	EGFR inhibitor, a cell permeable, 4,6-disubstituted pyrimidine compound, is a highly selevtive inhibitor of EGFR kinase with IC50 of 21 nM. EGFR inhibitor directly depolymerizes microtubules and is used as a chemical probe to investigate both the EGFR pathway and microtubule dynamics.	Cell Rep, 2022, 40-8:111223 Cancers (Basel), 2022, 14(19)4910 PLoS pathogens, 2016, 10.1371/journal.ppat.1005926
S4535	Methylene Blue	Methylene Blue (Basic Blue 9, Tetramethylthionine chloride, methylthioninium chloride, CI-52015) is used as a dye in chromoendoscopy. It Inhibits tau filament formation with IC50 of 1.9μM. Also it inhibits soluble guanylyl cyclase.	Cell Res, 2023, 10.1038/s41422-023-00846-8 bioRxiv, 2020, 2020/9/20.4.7.30734
S5256	Benproperine phosphate	Benproperine phosphate (Blascorid, Pirexyl), a cough suppressant, is an orally active, potent actin-related protein 2/3 complex subunit 2 (ARPC2) inhibitor. Benproperine phosphate attenuates the actin polymerization rate of action polymerization nucleation by impairing Arp2/3 function. Benproperine phosphate suppresses cancer cell migration and tumor metastasis.	Mol Oncol, 2020, 10.1002/1878-0261.12854
S3970	Vindoline	Vindoline is a chemical precursor to vinblastine and exhibits antimitotic activity by inhibiting microtubule assembly.	Nat Commun, 2020, 11(1):941
S9695	iHAP1	iHAP1 is a well-established microtubule poison, blocks microtubule polymerization fully at 5 µM which is independent of deregulated transcription, causes marked sensitization when deleting Rod1 gene in HeLa cells.	J Cell Biol, 2022, 221-11e202202100
S2254	4-Demethylepipodophyllotoxin(NSC-122819,VM-26)	4-Demethylepipodophyllotoxin (NSC-122819, VM-26, DMEP) is an antimitotic agent which binds to monomeric tubulin, preventing micro-tubule polymerization. It is a potent inhibitor of microtubule assembly.	Front Pharmacol, 2019, 10:381
S0328	MMAF	MMAF (Monomethylauristatin F) is a synthetic antineoplastic agent and a potent inhibitor of tubulin polymerization. MMAF (Monomethylauristatin F) is applied as a cytotoxic component of antibody-drug conjugates (ADCs) such as vorsetuzumab mafodotin, ABT-414 and SGN-CD19A.	Cancer Cell, 2021, S1535-6108(21)00659-0
E1068	Nab-Paclitaxel	Nab-Paclitaxel is a novel solvent-free paclitaxel in which the binding ratio of paclitaxel to human albumin is approximately 1:9. It is an anti-microtubule drug that promotes microtubule aggregation in tubulin dimers and inhibits microtubule depolymerization to stabilize the microtubule system. Solutions are unstable and should be fresh-prepared.	Cell Rep Med, 2024, S2666-3791(24)00652-9 Adv Ther (Weinh), 2024, 7(11)2400208 J Transl Med, 2023, 21(1):730
S7762	TRx0237 (LMTX) mesylate	TRx 0237 mesylate (LMTX, Hydromethylthionine) is a second-generation tau protein aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia.	Cell Res, 2025, 35(1):23-44 Nat Commun, 2023, 14(1):3939
S7493	INH1	INH1 (IBT 13131) is a cell-permeable Hec1 inhibitor, which specifically disrupts the Hec1/Nek2 interaction.	J Clin Invest, 2018, 128(7):2877-2893
S0444	Indibulin	Indibulin (ZIO 301, D 24851, Zybulin) is an orally applied inhibitor of tubulin assembly with potent anticancer activity. Indibulin induces mitotic arrest and apoptosis.	Bioorg Med Chem, 2020, 28(20):115712
S3220	Trigonelline	Trigonelline (Trigenolline) is a plant alkaloid and a major component of coffee and fenugreek with anti-degranulation, anti-diabetic, antioxidant, anti-inflammatory, and neuroprotective effects. Trigonelline inhibits FcεRI-mediated intracellular signaling pathways, such as phosphorylation of PLCγ1, PI3K, and Akt. Trigonelline (Trigenolline) also inhibits the microtubule formation in RBL-2H3 cells.	Int J Med Sci, 2025, 22(5):1194-1207 Biomed Pharmacother, 2021, 143:112204
F0167^New	β-Tubulin Rabbit mAb	beta Tubulin,beta Tubulin Loading Control,beta-Tubulin,β-Tubulin	Signal Transduct Target Ther, 2020, 5(1):44 Int Immunopharmacol, 2020, 89(Pt A):107030 Biomed Res Int, 2020, 2020:6507510
F0110^New	Vinculin Rabbit mAb		Exp Neurol, 2025, 390:115270
F0063^New	α-Tubulin Rabbit mAb	alpha Tubulin,alpha-Tubulin,TUBA1B,α-Tubulin	Cancer Cell Int, 2024, 24(1):191 Nat Commun, 2021, 12(1):5970
F0368^New	βIII-Tubulin Rabbit mAb	beta III Tubulin,beta-3 Tubulin,beta-III Tubulin,beta-Tubulin III,beta-Tubulin III (neuronal),beta-Tubulin Isotype III,Tubulin beta III,Tubulin betaIII,β3 Tubulin,β3-Tubulin
F0059^New	Phospho-Tau (Ser202/ Thr205) Mouse mAb	Phospho-Tau (Ser202, Thr205),Phospho-Tau (Ser202/Thr205),Tau (phospho S202 + T205)
F1566^New	Tubulin Rat mAb	Tubulin alpha-1B chain, Alpha-tubulin ubiquitous, Tubulin K-alpha-1, Tubulin alpha-ubiquitous chain, TUBA1B, Tubulin beta chain, Tubulin beta-5 chain, TUBB, TUBB5, OK/SW-cl.56, Tubulin alpha-4A chain, Alpha-tubulin 1, Testis-specific alpha-tubulin, Tubulin H2-alpha, Tubulin alpha-1 chain, TUBA4A, TUBA1, Tubulin beta-2A chain, Tubulin beta class IIa, TUBB2A, TUBB2	Cancer Cell Int, 2024, 24(1):191 Nat Commun, 2021, 12(1):5970
F0928	Tau Mouse mAb	Tau
F2311^New	Neuron-specific β-III Tubulin mAb	beta III Tubulin,beta-3 Tubulin,beta-III Tubulin,beta-Tubulin III,beta-Tubulin III (neuronal),beta-Tubulin Isotype III,Tubulin beta III,Tubulin betaIII,β3 Tubulin,β3-Tubulin
F0620^New	Acetyl-α-Tubulin (Lys40) Rabbit mAb	acetyl-alpha tubulin,Acetyl-alpha Tubulin (Lys40),Acetylated Tubulin,Acetyl-α-Tubulin (Lys40),alpha Tubulin (acetyl K40),alpha Tubulin acetyl K40,Tubulin, Acetylated
F3020^New	Phospho-Tau (Ser 416) Rabbit mAb	Phospho-Tau (Ser416),Tau (phospho S416)
F1675^New	β IV Tubulin Rabbit mAb	beta IV Tubulin,beta-Tubulin IV
F1411^New	TPX2 Rabbit mAb
F2614^New	Phospho-Tau (Ser 199) Rabbit mAb	Phospho-Tau (Ser199),Tau (phospho S199)
F2118^New	Plectin Rabbit mAb	Plectin,Plectin-1
F2687^New	γ-Tubulin mAb	gamma Tubulin,gamma-Tubulin,γ Tubulin,γ-Tubulin
F2472^New	TPPP Rabbit mAb	TPPP,TPPP/p25
S1836	Albendazole Oxide	Albendazole Oxide (Ricobendazole,Albendazole sulfoxide) is a tubulin polymerization or assembly inhibitor, used for the treatment of a variety of parasitic worm infestations.
S2440	Vindesine sulfate	Vindesine sulfate, a vinca alkaloid derived from Catharanthus roseus, is a potent inhibitor of mitosis with antineoplastic activities. Vindesine binds to the microtubular proteins of the mitotic spindle, leading to crystallization of the microtubule and mitotic arrest or cell death.	iScience, 2024, 27(10):110862 Sci Rep, 2020, 10(1):13124
S0510	Myoseverin	Myoseverin is a microtubule-binding trisubstituted purine, reversibly altering cellular function, directly binds tubulin and disrupts the structure of the microtubule cytoskeleton resulting in myotube fission at 20 μM.
S9969	RMC-4630	Vociprotafib (RMC-4630) is a potent, selective, orally bioavailable allosteric inhibitor of SHP2 with potential anti-tumor activity. RMC-4630 targets, binds to and inhibits the activity of SHP2, thereby inhibiting the activation of the RAS-RAF-MEK-ERK signaling pathway.
F0548^New	MAP2 Rabbit mAb	MAP2,MAP-2,Microtubule-Associated Protein 2 (MAP2)
E1894	PROTAC tubulin-Degrader-1(compound W13)	PROTAC tubulin-Degrader-1(compound W13) is an inhibitor of PROTAC tubulin exhibiting antitumor activity against human lung cancer.
S4114	Triclabendazole	Triclabendazole (CGA-89317,tcbz) is a benzimidazole, it binds to tubulin impairing intracellular transport mechanisms and interferes with protein synthesis.	Arch Biochem Biophys, 2024, 754:109958
S3374	Verubulin hydrochloride	Verubulin hydrochloride(MPC 6827 hydrochloride) is a microtubule destabilizer and vascular disrupting agent that achieve high brain concentration relative to plasma in animals.
E8284^New	PM534	PM534 is a potent microtubule-targeting agent (MTA) that binds the colchicine-binding domain (CBD) and inhibits tubulin assembly with IC50 values ranging from 0.8 to 3.2 nM. It also significantly inhibits tumor growth in mouse xenograft models of human non-small cell lung cancer.
S6954	CK-869	CK-869 (CK 0157869) is a small molecule inhibitor of actin-related protein 2/3 (Arp2/3) complex with an IC50 of 7 μM. CK-869 can directly suppresses microtubule assembly both in vitro and in vivo.
S8789	SSE15206	SSE15206 is a tubulin polymerization inhibitor that has potent antiproliferative activities in cancer cell lines of different origins and overcomes resistance to microtubule-targeting agents.
E7058^New	DM4	DM4 is a potent maytansinoid and potent inhibitor of tubulin. It binds to α/β-tubulin heterodimers and inhibits tubulin polymerization and microtubule assembly, leading to enhanced microtubule destabilization. This strong antimitotic activity results in suppressed microtubule dynamics, causing mitotic arrest and apoptotic cell death, making it valuable for studying acute myeloid leukemia (AML) therapies.
E1426^New	EAPB02303	EAPB02303 is a second-generation imiqualine that acts as a microtubule -disruptingagent and demonstrates anti-tumor effects and reduces tumor size in human melanoma xenografts.
D4003	Trastuzumab Emtansine（T-DM1）	Trastuzumab Emtansine(T-DM1,Ado-Trastuzumab emtansine) is an antibody-drug conjugate (ADC) that incorporates the HER2-targeted antitumor properties of trastuzumab with the cytotoxic activity of the microtubule-inhibitory agent DM1.Trastuzumab emtansine has a molecular weight of 145kDa.This product is supplied as 10mg/ml PBS solution.
S2447	Ansamitocin p-3 (Maytansinol isobutyrate, NSC292222)	Ansamitocin p-3 (Maytansinol isobutyrate, NSC292222, Antibiotic C 15003P3) is a potent inhibitor of tubulin polymerization with IC50 of 3.4 μM.
E4897^New	Estramustine	Estramustine(NSC-89201, LEO275) is used to treat hormone-resistant prostate cancer and stabilize microtubule dynamics. It acts as an anti-mitotic and anti-microtubule agent and disrupts microtubule disassembly. It inhibits the binding of MAPs 1 and 2 to taxol-stabilized microtubules, hinders microtubule assembly, and promotes the disassembly of MAP-2-associated microtubules.
S4071	Griseofulvin	Griseofulvin, a production from some strains of the mold Penicillium griseofulvumam, is able to inhibit cell mitosis by interfering with microtubule function.	Leukemia, 2024, 38(5):969-980 Genes (Basel), 2024, 16(1)14
S3725	ELR-510444	ELR-510444 is a novel microtubule disruptor with potential antivascular effects and in vivo antitumor efficacy, causing a loss of cellular microtubules and the formation of aberrant mitotic spindles and leading to mitotic arrest and apoptosis of cancer cells.
A2692	Gosuranemab (Anti-Tau)	Gosuranemab (Anti-Tau) is a humanized monoclonal antibody against the extracellular N-terminal of tau in the interstitial fluid (ISF) and CSF released by neurons. It has the potential for research of alzheimer’s disease (AD). MW : 150 kD.
A2693	Semorinemab (Anti-Tau)	Semorinemab (Anti-Tau) is a humanized IgG4 monoclonal antibody that targets the N-terminal domain of tau (amino acid residues 6-23). Semorinemab has the potential to be used in research on Alzheimer's disease. MW : 150 kD.
S6661	VcMMAE	VcMMAE (mc-vc-PAB-MMAE), a MMAE derivative with valine-citrulline (Vc) linker,is an Drug-linker Conjugate for antibody-drug conjugate (ADC) with potent antitumor activity. MMAE is a synthetic antineoplastic agent and can be efficiently released from VcMMAE in vitro and exert cytotoxic activity.
S6772^New	VERU-111	Sabizabulin (VERU-111, ABI-231) is a potent, orally bioavailable inhibitor of tubulin that binds to the colchicine binding site. It inhibits the expression of β tubulin (III, IV) and α tubulin, with the potential to treat prostate cancer. It also exhibits significant anti-proliferative activity, with an average IC50 of 5.2 nM across a broad panel of cancer cell lines.
S6773	DM1 (Mertansine)	DM1 (Mertansine), an antibody-conjugatable maytansinoid, is a selective microtubule inhibitor that is developed to overcome systemic toxicity associated with maytansine and to enhance tumor-specific delivery. Mertansine can be attached to a monoclonal antibody with a linker to create an antibody-drug conjugate (ADC).Solutions are unstable and should be fresh-prepared.
S7494	INH6	INH6 is a potent Hec1 inhibitor, which specifically disrupts the Hec1/Nek2 interaction and causes chromosome mis-alignment.
S3206	5a-Pregnane-3,20-dione	5a-Pregnane-3,20-dione (5alphaP, 5-a-dihydroprogesterone, 3,20-allopregnanedione, 5-Alpha-Dihydro Progesterone) is the endogenous progesterone metabolite. 5a-Pregnane-3,20-dione depolymerizes actin and decreases expression of actin and vinculin. 5a-Pregnane-3,20-dione is involved in promoting breast neoplasia and metastasis by affecting adhesion and cytoskeletal molecules.
E2402	T-1101 tosylate	T-1101 tosylate (TAI-95 tosylate) is a Hec1/Nek2 (Highly expressed in cancer 1 / NIMA-related kinase 2) inhibitor with antitumor activity.
S8912	Eribulin Mesylate	Eribulin Mesylate, an analogue of the marine natural product halichondrin B, is a nontaxane completely synthetic microtubule inhibitor.	bioRxiv, 2024, 2024.12.12.628190
S2441	Estramustine phosphate sodium	Estramustine phosphate sodium (EMP, Emcyt, Estracyt) is an antitumour drug with a unique dual mode of action. Estrone and estradiol, products of the metabolism of estramustine phosphate sodium, have shown antigonadotrophic activity resulting in reduced testosterone levels. Estramustine(the cytotoxic metabolite produced by dephosphorylation of estramustine phosphate sodium) is an antiprostatic tumor drug with antimicrotubule effects.	iScience, 2024, 27(10):110862
S2444	Parbendazole	Parbendazole (SKF 29044) is an extremely potent inhibitor of microtubule assembly with IC50 of 3 µM for the assembly of brain microtubules.
S9555	Vincristine	Vincristine (Leurocristine, NSC-67574, 22-Oxovincaleukoblastine) is a natural alkaloid isolated from the plant Vinca rosea Linn. with anti-tumor activity. Vincristine inhibits microtubule formation in mitotic spindle and binds to microtubule with Ki of 85 nM.	Cell Rep Med, 2025, S2666-3791(25)00102-8 Molecules, 2025, 30(10)2186 iScience, 2024, 27(10):110862
E2851	Trastuzumab-Emtansine（T-DM1）	Trastuzumab Emtansine(T-DM1,Ado-Trastuzumab emtansine) is an antibody-drug conjugate (ADC) that incorporates the HER2-targeted antitumor properties of trastuzumab with the cytotoxic activity of the microtubule-inhibitory agent DM1.Trastuzumab emtansine has a molecular weight of 145kDa.This product is supplied as 10mg/ml PBS solution. This product is discontinued. We recommend the replacement products: D4003
A2341	Zagotenemab (Anti-Tau)	Zagotenemab (Anti-Tau) is a humanised anti-tau antibody that selectively binds and neutralises tau deposits in the brain. It has the potential to be used in Alzheimer's disease research. MW : 145.5 KD
S5919	KHS101 hydrochloride	KHS101 is a small-molecule inhibitor of TACC3, which is a key component of centrosome-microtubule dynamic networks.
S1150	Paclitaxel	Paclitaxel is a microtubule polymer stabilizer with IC50 of 0.1 pM in human endothelial cells.Paclitaxel can cause both mitotic arrest and apoptotic cell death. Paclitaxel also induces autophagy.	Nature, 2025, 10.1038/s41586-025-08974-4 Cell, 2025, S0092-8674(25)00386-1 Cell Res, 2025, 35(6):437-452.
S1148	Docetaxel	Docetaxel, an analog of paclitaxel, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules.	Adv Sci (Weinh), 2025, 12(10):e2413174 Adv Sci (Weinh), 2025, 12(10):e2411769 Commun Biol, 2025, 8(1):152
S1241	Vincristine sulfate	Vincristine sulfate is an inhibitor of polymerization of microtubules by binding to tubulin with IC50 of 32 μM in a cell-free assay. Vincristine sulfate induces apoptosis.	Cell Rep, 2025, 44(4):115434 J Transl Med, 2025, 23(1):542 J Biol Chem, 2025, S0021-9258(25)00076-6
S2775	Nocodazole	Nocodazole is a rapidly-reversible inhibitor of microtubule polymerization, also inhibits Abl, Abl(E255K) and Abl(T315I) with IC50 of 0.21 μM, 0.53 μM and 0.64 μM in cell-free assays, respectively. Nocodazole induces apoptosis.	Clin Transl Med, 2025, 15(1):e70164 Cancer Res Commun, 2025, 5(4):648-667 Signal Transduct Target Ther, 2024, 9(1):181.
S7787	Docetaxel Trihydrate	Docetaxel (RP56976, NSC 628503), an analog of paclitaxel, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules.	iScience, 2024, 27(10):110862 PLoS Biol, 2023, 21(4):e3002038 Mol Cancer, 2022, 21(1):150
S4505	Vinblastine sulfate	Vinblastine sulfate inhibits microtubule formation and suppresses nAChR activity with IC50 of 8.9 μM in a cell-free assay, used to treat certain kinds of cancer. Vinblastine sulfate induces autophagy and apoptosis.	Int J Mol Sci, 2025, 26(8)3864 Anticancer Res, 2025, 45(1):39-53 iScience, 2024, 27(10):110862
S4269	Vinorelbine ditartrate	Vinorelbine ditartrate is a semi-synthetic vinca alkaloid, and inhibits mitosis through interaction with tubulin. Vinorelbine Tartrate exhibits anti-tumor activities via inducing the mitotic apoptosis, autophagy and inflammation.	Commun Biol, 2025, 8(1):152 Sci Rep, 2025, 15(1):11372 Cell Death Dis, 2024, 15(8):603
S3022	Cabazitaxel	Cabazitaxel is a semi-synthetic derivative of a natural taxoid that kills cancer cells by inhibiting cell division and growth. Cabazitaxel exerts its effects by inhibiting microtubule growth and assembly, processes that are essential for cells to divide. Cabazitaxel induces autophagy via the PI3K/Akt/mTOR pathway.	J Photochem Photobiol B, 2024, 253:112877 Cancer Biol Ther, 2024, 25(1):2329368 Oncol Lett, 2024, 28(6):605
S2284	Colchicine	Colchicine is a microtubule polymerization inhibitor with an IC50 of 3 nM.	Int J Mol Sci, 2025, 26(8)3864 Eur J Pharmacol, 2024, 983:176968 Biomedicines, 2024, 12(2)406
S1364	Patupilone (Epothilone B)	Patupilone (EPO906, Epothilone B) is a microtubule-stabilizing agent with EC_0.01 of 1.8 μM. Phase 2.	Brain Commun, 2023, 5(1):fcad005 Brain, 2022, awac079 Genome Med, 2021, 13(1):189
S7930	Ixabepilone	Ixabepilone is an orally bioavailable microtubule inhibitor. It binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arresting cells in the G2-M phase of the cell cycle and inducing tumor cell apoptosis.	J Pers Med, 2022, 12(2)258 Pharmacol Rep, 2022, 10.1007/s43440-022-00396-7 Hum Cell, 2022, 10.1007/s13577-022-00671-y
S7204	Fosbretabulin (Combretastatin A4 Phosphate) Disodium	Fosbretabulin (Combretastatin A4 Phosphate) Disodium is the water-soluble prodrug of Combretastatin A4 (CA4), which is a microtubule-targeting agent that binds β-tubulin with K_d of 0.4 μM in a cell-free assay. Fosbretabulin Disodium inhibits the polymerization of tubulin with IC50 of 2.4 μM, and also disrupts tumor vasculature. Fosbretabulin disodium induces mitotic arrest and apoptosis in endothelial cells. Phase 3.	Front Oncol, 2023, 13:1249524 Front Oncol, 2023, 13:1249524 Cell, 2020, 182(3):685-712.e19
S2195	Lexibulin (CYT997)	Lexibulin (CYT997, SRI-32007) is a potent microtubule polymerization inhibitor with IC50 of 10-100 nM in cancer cell lines. Phase 2.	Cell, 2021, 184(2):334-351.e20 Adv Virol, 2020, 2020:8844061 J Exp Clin Cancer Res, 2019, 38(1):44
S1640	Albendazole	Albendazole is a member of the benzimidazole compounds used as a drug indicated for the treatment of a variety of worm infestations.	Sci Rep, 2022, 12(1):5706 Mol Cell, 2021, 81(19):4041-4058.e15 Cancer Lett, 2021, 520:307-320
S7336	CW069	CW069 is an allosteric, and selective inhibitor of microtubule motor protein HSET with IC50 of 75 μM, significant selectivity over KSP.	Nat Commun, 2023, 14(1):6505 Nat Commun, 2023, 14(1):6505 Life Sci Alliance, 2022, 5(11)e202201470
S7721	MMAE (Monomethyl auristatin E)	MMAE (Monomethyl auristatin E) is a synthetic antineoplastic agent. It is also a microtubule-disrupting agent .	Front Immunol, 2024, 15:1393485 Leuk Lymphoma, 2023, 1-11. Br J Haematol, 2022, 10.1111/bjh.18341
S1165	ABT-751 (E7010)	ABT-751 (E7010) binds to the colchicine site on β-tubulin and inhibits polymerization of microtubules, not a substrate for the MDR transporter and is active against cell lines resistant to vincristine, doxorubicin, and cisplatin. Phase 1/2.	J Clin Invest, 2020, 10.1172/JCI122462 Fitoterapia, 2017, 116:106-115 PLoS Genet, 2016, 12(9):e1006279
S7783	Combretastatin A4	Combretastatin A4 is a microtubule-targeting agent that binds β-tubulin with K_d of 0.4 μM.Phase 3.	EMBO Mol Med, 2025, 10.1038/s44321-025-00222-6 Mol Cell, 2023, 83(13):2290-2302.e13 Mol Cell, 2023, 83(13):2290-2302.e13
S7497	CK-636	CK-636 (CK-0944636) is an Arp2/3 complex inhibitor with IC50 of 4 μM, 24 μM and 32 μM for inhibition of actin polymerization induced by human, fission yeast and bovine Arp2/3 complex, respectively.	J Biol Chem, 2024, 300(12):107942 Elife, 2021, 10e65910 Theranostics, 2019, 9(25):7628-7647
S1297	Epothilone A	Epothilone A is a paclitaxel-like microtubule-stabilizing agent with EC_0.01 of 2 μM.	Environ Mol Mutagen, 2024, 10.1002/em.22604 Environ Mol Mutagen, 2022, 63(3):151-161 Cancers (Basel), 2020, 12(12)E3816
S7495	TAI-1	TAI-1 is a potent and specific Hec1 inhibitor, which disrupts Hec1-Nek2 protein interaction.	J Exp Clin Cancer Res, 2019, 18;38(1):316 Curr Biol, 2019, 29(18):3072-3080.e5 Curr Biol, 2019, 29(18):3072-3080
S4535	Methylene Blue	Methylene Blue (Basic Blue 9, Tetramethylthionine chloride, methylthioninium chloride, CI-52015) is used as a dye in chromoendoscopy. It Inhibits tau filament formation with IC50 of 1.9μM. Also it inhibits soluble guanylyl cyclase.	Cell Res, 2023, 10.1038/s41422-023-00846-8 bioRxiv, 2020, 2020/9/20.4.7.30734
S5256	Benproperine phosphate	Benproperine phosphate (Blascorid, Pirexyl), a cough suppressant, is an orally active, potent actin-related protein 2/3 complex subunit 2 (ARPC2) inhibitor. Benproperine phosphate attenuates the actin polymerization rate of action polymerization nucleation by impairing Arp2/3 function. Benproperine phosphate suppresses cancer cell migration and tumor metastasis.	Mol Oncol, 2020, 10.1002/1878-0261.12854
S3970	Vindoline	Vindoline is a chemical precursor to vinblastine and exhibits antimitotic activity by inhibiting microtubule assembly.	Nat Commun, 2020, 11(1):941
S9695	iHAP1	iHAP1 is a well-established microtubule poison, blocks microtubule polymerization fully at 5 µM which is independent of deregulated transcription, causes marked sensitization when deleting Rod1 gene in HeLa cells.	J Cell Biol, 2022, 221-11e202202100
S2254	4-Demethylepipodophyllotoxin(NSC-122819,VM-26)	4-Demethylepipodophyllotoxin (NSC-122819, VM-26, DMEP) is an antimitotic agent which binds to monomeric tubulin, preventing micro-tubule polymerization. It is a potent inhibitor of microtubule assembly.	Front Pharmacol, 2019, 10:381
S0328	MMAF	MMAF (Monomethylauristatin F) is a synthetic antineoplastic agent and a potent inhibitor of tubulin polymerization. MMAF (Monomethylauristatin F) is applied as a cytotoxic component of antibody-drug conjugates (ADCs) such as vorsetuzumab mafodotin, ABT-414 and SGN-CD19A.	Cancer Cell, 2021, S1535-6108(21)00659-0
E1068	Nab-Paclitaxel	Nab-Paclitaxel is a novel solvent-free paclitaxel in which the binding ratio of paclitaxel to human albumin is approximately 1:9. It is an anti-microtubule drug that promotes microtubule aggregation in tubulin dimers and inhibits microtubule depolymerization to stabilize the microtubule system. Solutions are unstable and should be fresh-prepared.	Cell Rep Med, 2024, S2666-3791(24)00652-9 Adv Ther (Weinh), 2024, 7(11)2400208 J Transl Med, 2023, 21(1):730
S7762	TRx0237 (LMTX) mesylate	TRx 0237 mesylate (LMTX, Hydromethylthionine) is a second-generation tau protein aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia.	Cell Res, 2025, 35(1):23-44 Nat Commun, 2023, 14(1):3939
S7493	INH1	INH1 (IBT 13131) is a cell-permeable Hec1 inhibitor, which specifically disrupts the Hec1/Nek2 interaction.	J Clin Invest, 2018, 128(7):2877-2893
S0444	Indibulin	Indibulin (ZIO 301, D 24851, Zybulin) is an orally applied inhibitor of tubulin assembly with potent anticancer activity. Indibulin induces mitotic arrest and apoptosis.	Bioorg Med Chem, 2020, 28(20):115712
S3220	Trigonelline	Trigonelline (Trigenolline) is a plant alkaloid and a major component of coffee and fenugreek with anti-degranulation, anti-diabetic, antioxidant, anti-inflammatory, and neuroprotective effects. Trigonelline inhibits FcεRI-mediated intracellular signaling pathways, such as phosphorylation of PLCγ1, PI3K, and Akt. Trigonelline (Trigenolline) also inhibits the microtubule formation in RBL-2H3 cells.	Int J Med Sci, 2025, 22(5):1194-1207 Biomed Pharmacother, 2021, 143:112204
S1836	Albendazole Oxide	Albendazole Oxide (Ricobendazole,Albendazole sulfoxide) is a tubulin polymerization or assembly inhibitor, used for the treatment of a variety of parasitic worm infestations.
S2440	Vindesine sulfate	Vindesine sulfate, a vinca alkaloid derived from Catharanthus roseus, is a potent inhibitor of mitosis with antineoplastic activities. Vindesine binds to the microtubular proteins of the mitotic spindle, leading to crystallization of the microtubule and mitotic arrest or cell death.	iScience, 2024, 27(10):110862 Sci Rep, 2020, 10(1):13124
S0510	Myoseverin	Myoseverin is a microtubule-binding trisubstituted purine, reversibly altering cellular function, directly binds tubulin and disrupts the structure of the microtubule cytoskeleton resulting in myotube fission at 20 μM.
S9969	RMC-4630	Vociprotafib (RMC-4630) is a potent, selective, orally bioavailable allosteric inhibitor of SHP2 with potential anti-tumor activity. RMC-4630 targets, binds to and inhibits the activity of SHP2, thereby inhibiting the activation of the RAS-RAF-MEK-ERK signaling pathway.
E1894	PROTAC tubulin-Degrader-1(compound W13)	PROTAC tubulin-Degrader-1(compound W13) is an inhibitor of PROTAC tubulin exhibiting antitumor activity against human lung cancer.
S4114	Triclabendazole	Triclabendazole (CGA-89317,tcbz) is a benzimidazole, it binds to tubulin impairing intracellular transport mechanisms and interferes with protein synthesis.	Arch Biochem Biophys, 2024, 754:109958
E8284^New	PM534	PM534 is a potent microtubule-targeting agent (MTA) that binds the colchicine-binding domain (CBD) and inhibits tubulin assembly with IC50 values ranging from 0.8 to 3.2 nM. It also significantly inhibits tumor growth in mouse xenograft models of human non-small cell lung cancer.
S6954	CK-869	CK-869 (CK 0157869) is a small molecule inhibitor of actin-related protein 2/3 (Arp2/3) complex with an IC50 of 7 μM. CK-869 can directly suppresses microtubule assembly both in vitro and in vivo.
S8789	SSE15206	SSE15206 is a tubulin polymerization inhibitor that has potent antiproliferative activities in cancer cell lines of different origins and overcomes resistance to microtubule-targeting agents.
E7058^New	DM4	DM4 is a potent maytansinoid and potent inhibitor of tubulin. It binds to α/β-tubulin heterodimers and inhibits tubulin polymerization and microtubule assembly, leading to enhanced microtubule destabilization. This strong antimitotic activity results in suppressed microtubule dynamics, causing mitotic arrest and apoptotic cell death, making it valuable for studying acute myeloid leukemia (AML) therapies.
E1426^New	EAPB02303	EAPB02303 is a second-generation imiqualine that acts as a microtubule -disruptingagent and demonstrates anti-tumor effects and reduces tumor size in human melanoma xenografts.
D4003	Trastuzumab Emtansine（T-DM1）	Trastuzumab Emtansine(T-DM1,Ado-Trastuzumab emtansine) is an antibody-drug conjugate (ADC) that incorporates the HER2-targeted antitumor properties of trastuzumab with the cytotoxic activity of the microtubule-inhibitory agent DM1.Trastuzumab emtansine has a molecular weight of 145kDa.This product is supplied as 10mg/ml PBS solution.
S2447	Ansamitocin p-3 (Maytansinol isobutyrate, NSC292222)	Ansamitocin p-3 (Maytansinol isobutyrate, NSC292222, Antibiotic C 15003P3) is a potent inhibitor of tubulin polymerization with IC50 of 3.4 μM.
E4897^New	Estramustine	Estramustine(NSC-89201, LEO275) is used to treat hormone-resistant prostate cancer and stabilize microtubule dynamics. It acts as an anti-mitotic and anti-microtubule agent and disrupts microtubule disassembly. It inhibits the binding of MAPs 1 and 2 to taxol-stabilized microtubules, hinders microtubule assembly, and promotes the disassembly of MAP-2-associated microtubules.
S4071	Griseofulvin	Griseofulvin, a production from some strains of the mold Penicillium griseofulvumam, is able to inhibit cell mitosis by interfering with microtubule function.	Leukemia, 2024, 38(5):969-980 Genes (Basel), 2024, 16(1)14
S3725	ELR-510444	ELR-510444 is a novel microtubule disruptor with potential antivascular effects and in vivo antitumor efficacy, causing a loss of cellular microtubules and the formation of aberrant mitotic spindles and leading to mitotic arrest and apoptosis of cancer cells.
S6661	VcMMAE	VcMMAE (mc-vc-PAB-MMAE), a MMAE derivative with valine-citrulline (Vc) linker,is an Drug-linker Conjugate for antibody-drug conjugate (ADC) with potent antitumor activity. MMAE is a synthetic antineoplastic agent and can be efficiently released from VcMMAE in vitro and exert cytotoxic activity.
S6772^New	VERU-111	Sabizabulin (VERU-111, ABI-231) is a potent, orally bioavailable inhibitor of tubulin that binds to the colchicine binding site. It inhibits the expression of β tubulin (III, IV) and α tubulin, with the potential to treat prostate cancer. It also exhibits significant anti-proliferative activity, with an average IC50 of 5.2 nM across a broad panel of cancer cell lines.
S6773	DM1 (Mertansine)	DM1 (Mertansine), an antibody-conjugatable maytansinoid, is a selective microtubule inhibitor that is developed to overcome systemic toxicity associated with maytansine and to enhance tumor-specific delivery. Mertansine can be attached to a monoclonal antibody with a linker to create an antibody-drug conjugate (ADC).Solutions are unstable and should be fresh-prepared.
S7494	INH6	INH6 is a potent Hec1 inhibitor, which specifically disrupts the Hec1/Nek2 interaction and causes chromosome mis-alignment.
S3206	5a-Pregnane-3,20-dione	5a-Pregnane-3,20-dione (5alphaP, 5-a-dihydroprogesterone, 3,20-allopregnanedione, 5-Alpha-Dihydro Progesterone) is the endogenous progesterone metabolite. 5a-Pregnane-3,20-dione depolymerizes actin and decreases expression of actin and vinculin. 5a-Pregnane-3,20-dione is involved in promoting breast neoplasia and metastasis by affecting adhesion and cytoskeletal molecules.
E2402	T-1101 tosylate	T-1101 tosylate (TAI-95 tosylate) is a Hec1/Nek2 (Highly expressed in cancer 1 / NIMA-related kinase 2) inhibitor with antitumor activity.
S8912	Eribulin Mesylate	Eribulin Mesylate, an analogue of the marine natural product halichondrin B, is a nontaxane completely synthetic microtubule inhibitor.	bioRxiv, 2024, 2024.12.12.628190
S2441	Estramustine phosphate sodium	Estramustine phosphate sodium (EMP, Emcyt, Estracyt) is an antitumour drug with a unique dual mode of action. Estrone and estradiol, products of the metabolism of estramustine phosphate sodium, have shown antigonadotrophic activity resulting in reduced testosterone levels. Estramustine(the cytotoxic metabolite produced by dephosphorylation of estramustine phosphate sodium) is an antiprostatic tumor drug with antimicrotubule effects.	iScience, 2024, 27(10):110862
S2444	Parbendazole	Parbendazole (SKF 29044) is an extremely potent inhibitor of microtubule assembly with IC50 of 3 µM for the assembly of brain microtubules.
S9555	Vincristine	Vincristine (Leurocristine, NSC-67574, 22-Oxovincaleukoblastine) is a natural alkaloid isolated from the plant Vinca rosea Linn. with anti-tumor activity. Vincristine inhibits microtubule formation in mitotic spindle and binds to microtubule with Ki of 85 nM.	Cell Rep Med, 2025, S2666-3791(25)00102-8 Molecules, 2025, 30(10)2186 iScience, 2024, 27(10):110862
E2851	Trastuzumab-Emtansine（T-DM1）	Trastuzumab Emtansine(T-DM1,Ado-Trastuzumab emtansine) is an antibody-drug conjugate (ADC) that incorporates the HER2-targeted antitumor properties of trastuzumab with the cytotoxic activity of the microtubule-inhibitory agent DM1.Trastuzumab emtansine has a molecular weight of 145kDa.This product is supplied as 10mg/ml PBS solution. This product is discontinued. We recommend the replacement products: D4003
S5919	KHS101 hydrochloride	KHS101 is a small-molecule inhibitor of TACC3, which is a key component of centrosome-microtubule dynamic networks.
A2692	Gosuranemab (Anti-Tau)	Gosuranemab (Anti-Tau) is a humanized monoclonal antibody against the extracellular N-terminal of tau in the interstitial fluid (ISF) and CSF released by neurons. It has the potential for research of alzheimer’s disease (AD). MW : 150 kD.
A2693	Semorinemab (Anti-Tau)	Semorinemab (Anti-Tau) is a humanized IgG4 monoclonal antibody that targets the N-terminal domain of tau (amino acid residues 6-23). Semorinemab has the potential to be used in research on Alzheimer's disease. MW : 150 kD.
A2341	Zagotenemab (Anti-Tau)	Zagotenemab (Anti-Tau) is a humanised anti-tau antibody that selectively binds and neutralises tau deposits in the brain. It has the potential to be used in Alzheimer's disease research. MW : 145.5 KD
S1233	2-Methoxyestradiol (2-MeOE2)	2-Methoxyestradiol (2-MeOE2, NSC 659853, 2-ME2) depolymerizes microtubules and blocks HIF-1α nuclear accumulation and HIF-transcriptional activity. 2-Methoxyestradiol induces both autophagy and apoptosis in various carcinogenic cell lines.	Nat Commun, 2025, 16(1):4681 Int J Nanomedicine, 2025, 20:933-950 Theranostics, 2024, 14(13):5123-5140
S1176	Plinabulin	Plinabulin is a vascular disrupting agent (VDA) against tubulin-depolymerizing with IC50 of 9.8~18 nM in tumor cells. Phase 1/2.	J Med Chem, 2022, 65(13):9159-9173 ACS Omega, 2022, 7(25):21465-21472 J Biol Chem, 2019, 294(20):8161-8170
S0360	EGFR Inhibitor	EGFR inhibitor, a cell permeable, 4,6-disubstituted pyrimidine compound, is a highly selevtive inhibitor of EGFR kinase with IC50 of 21 nM. EGFR inhibitor directly depolymerizes microtubules and is used as a chemical probe to investigate both the EGFR pathway and microtubule dynamics.	Cell Rep, 2022, 40-8:111223 Cancers (Basel), 2022, 14(19)4910 PLoS pathogens, 2016, 10.1371/journal.ppat.1005926
S3374	Verubulin hydrochloride	Verubulin hydrochloride(MPC 6827 hydrochloride) is a microtubule destabilizer and vascular disrupting agent that achieve high brain concentration relative to plasma in animals.
F0167^New	β-Tubulin Rabbit mAb	beta Tubulin,beta Tubulin Loading Control,beta-Tubulin,β-Tubulin	Signal Transduct Target Ther, 2020, 5(1):44 Int Immunopharmacol, 2020, 89(Pt A):107030 Biomed Res Int, 2020, 2020:6507510
F0110^New	Vinculin Rabbit mAb		Exp Neurol, 2025, 390:115270
F0063^New	α-Tubulin Rabbit mAb	alpha Tubulin,alpha-Tubulin,TUBA1B,α-Tubulin	Cancer Cell Int, 2024, 24(1):191 Nat Commun, 2021, 12(1):5970
F0368^New	βIII-Tubulin Rabbit mAb	beta III Tubulin,beta-3 Tubulin,beta-III Tubulin,beta-Tubulin III,beta-Tubulin III (neuronal),beta-Tubulin Isotype III,Tubulin beta III,Tubulin betaIII,β3 Tubulin,β3-Tubulin
F0059^New	Phospho-Tau (Ser202/ Thr205) Mouse mAb	Phospho-Tau (Ser202, Thr205),Phospho-Tau (Ser202/Thr205),Tau (phospho S202 + T205)
F1566^New	Tubulin Rat mAb	Tubulin alpha-1B chain, Alpha-tubulin ubiquitous, Tubulin K-alpha-1, Tubulin alpha-ubiquitous chain, TUBA1B, Tubulin beta chain, Tubulin beta-5 chain, TUBB, TUBB5, OK/SW-cl.56, Tubulin alpha-4A chain, Alpha-tubulin 1, Testis-specific alpha-tubulin, Tubulin H2-alpha, Tubulin alpha-1 chain, TUBA4A, TUBA1, Tubulin beta-2A chain, Tubulin beta class IIa, TUBB2A, TUBB2	Cancer Cell Int, 2024, 24(1):191 Nat Commun, 2021, 12(1):5970
F2311^New	Neuron-specific β-III Tubulin mAb	beta III Tubulin,beta-3 Tubulin,beta-III Tubulin,beta-Tubulin III,beta-Tubulin III (neuronal),beta-Tubulin Isotype III,Tubulin beta III,Tubulin betaIII,β3 Tubulin,β3-Tubulin
F0620^New	Acetyl-α-Tubulin (Lys40) Rabbit mAb	acetyl-alpha tubulin,Acetyl-alpha Tubulin (Lys40),Acetylated Tubulin,Acetyl-α-Tubulin (Lys40),alpha Tubulin (acetyl K40),alpha Tubulin acetyl K40,Tubulin, Acetylated
F3020^New	Phospho-Tau (Ser 416) Rabbit mAb	Phospho-Tau (Ser416),Tau (phospho S416)
F1675^New	β IV Tubulin Rabbit mAb	beta IV Tubulin,beta-Tubulin IV
F1411^New	TPX2 Rabbit mAb
F2614^New	Phospho-Tau (Ser 199) Rabbit mAb	Phospho-Tau (Ser199),Tau (phospho S199)
F2118^New	Plectin Rabbit mAb	Plectin,Plectin-1
F2687^New	γ-Tubulin mAb	gamma Tubulin,gamma-Tubulin,γ Tubulin,γ-Tubulin
F2472^New	TPPP Rabbit mAb	TPPP,TPPP/p25
F0548^New	MAP2 Rabbit mAb	MAP2,MAP-2,Microtubule-Associated Protein 2 (MAP2)
E8284^New	PM534	PM534 is a potent microtubule-targeting agent (MTA) that binds the colchicine-binding domain (CBD) and inhibits tubulin assembly with IC50 values ranging from 0.8 to 3.2 nM. It also significantly inhibits tumor growth in mouse xenograft models of human non-small cell lung cancer.
E7058^New	DM4	DM4 is a potent maytansinoid and potent inhibitor of tubulin. It binds to α/β-tubulin heterodimers and inhibits tubulin polymerization and microtubule assembly, leading to enhanced microtubule destabilization. This strong antimitotic activity results in suppressed microtubule dynamics, causing mitotic arrest and apoptotic cell death, making it valuable for studying acute myeloid leukemia (AML) therapies.
E1426^New	EAPB02303	EAPB02303 is a second-generation imiqualine that acts as a microtubule -disruptingagent and demonstrates anti-tumor effects and reduces tumor size in human melanoma xenografts.
E4897^New	Estramustine	Estramustine(NSC-89201, LEO275) is used to treat hormone-resistant prostate cancer and stabilize microtubule dynamics. It acts as an anti-mitotic and anti-microtubule agent and disrupts microtubule disassembly. It inhibits the binding of MAPs 1 and 2 to taxol-stabilized microtubules, hinders microtubule assembly, and promotes the disassembly of MAP-2-associated microtubules.
S6772^New	VERU-111	Sabizabulin (VERU-111, ABI-231) is a potent, orally bioavailable inhibitor of tubulin that binds to the colchicine binding site. It inhibits the expression of β tubulin (III, IV) and α tubulin, with the potential to treat prostate cancer. It also exhibits significant anti-proliferative activity, with an average IC50 of 5.2 nM across a broad panel of cancer cell lines.

Choose Selective Microtubule Associated Inhibitors

Microtubule AssociatedSignaling Pathway