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Microtubule Associated Inhibitors

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Cat.No. Product Name Information Product Use Citations Product Validations
E1068 Nab-Paclitaxel Nab-Paclitaxel is a novel solvent-free paclitaxel in which the binding ratio of paclitaxel to human albumin is approximately 1:9. It is an anti-microtubule drug that promotes microtubule aggregation in tubulin dimers and inhibits microtubule depolymerization to stabilize the microtubule system. Solutions are unstable and should be fresh-prepared.
Mol Ther, 2025, 33(12):6160-6177
J Nanobiotechnology, 2025, 23(1):691
Br J Cancer, 2025, 10.1038/s41416-025-03185-0
S1148 Docetaxel Docetaxel, an analog of paclitaxel, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules.
NPJ Precis Oncol, 2026, 10.1038/s41698-026-01400-6
Cells, 2026, 15(4)383
Cancer Discov, 2025, 10.1158/2159-8290.CD-25-0629
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S2775 Nocodazole Nocodazole is a rapidly-reversible inhibitor of microtubule polymerization, also inhibits Abl, Abl(E255K) and Abl(T315I) with IC50 of 0.21 μM, 0.53 μM and 0.64 μM in cell-free assays, respectively. Nocodazole induces apoptosis.
Adv Mater, 2025, e17493.
Nat Commun, 2025, 16(1):7898
EMBO J, 2025, 44(22):6556-6597
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S0328 MMAF (Monomethylauristatin F) MMAF (Monomethylauristatin F) is a synthetic antineoplastic agent and a potent inhibitor of tubulin polymerization. MMAF (Monomethylauristatin F) is applied as a cytotoxic component of antibody-drug conjugates (ADCs) such as vorsetuzumab mafodotin, ABT-414 and SGN-CD19A.
Cancer Cell, 2021, S1535-6108(21)00659-0
S1150 Paclitaxel Paclitaxel is a microtubule polymer stabilizer with IC50 of 0.1 pM in human endothelial cells.Paclitaxel can cause both mitotic arrest and apoptotic cell death. Paclitaxel also induces autophagy.
Cancer Research, March 01, 2021, 1413-1425
International Journal of Molecular Medicine, February 01, 2019, 1866-1878
Therapeutic Advances in Medical Oncology, December 11, 2024, 17588359241303302
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S1241 Vincristine (Leurocristine) Sulfate Vincristine sulfate is an inhibitor of polymerization of microtubules by binding to tubulin with IC50 of 32 μM in a cell-free assay. Vincristine sulfate induces apoptosis.
International Journal of Molecular Sciences, October 25, 2023, 15571
eLife, November 19, 2019, e50036
Oncotarget, November 05, 2019, 6403-6417
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S7721 MMAE (Monomethyl auristatin E) MMAE (Monomethyl auristatin E) is a synthetic antineoplastic agent. It is also a microtubule-disrupting agent .
Front Immunol, 2024, 15:1393485
Leuk Lymphoma, 2023, 1-11.
Br J Haematol, 2022, 10.1111/bjh.18341
S9555 Vincristine Vincristine (Leurocristine, NSC-67574, 22-Oxovincaleukoblastine) is a natural alkaloid isolated from the plant Vinca rosea Linn. with anti-tumor activity. Vincristine inhibits microtubule formation in mitotic spindle and binds to microtubule with Ki of 85 nM.
Nat Commun, 2025, 16(1):4133
Cell Rep Med, 2025, S2666-3791(25)00102-8
Proc Natl Acad Sci U S A, 2025, 122(28):e2507203122
S7787 Docetaxel Trihydrate Docetaxel (RP56976, NSC 628503), an analog of paclitaxel, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules.
iScience, 2024, 27(10):110862
PLoS Biol, 2023, 21(4):e3002038
Mol Cancer, 2022, 21(1):150
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S4269 Vinorelbine Ditartrate (KW-2307) Vinorelbine ditartrate is a semi-synthetic vinca alkaloid, and inhibits mitosis through interaction with tubulin. Vinorelbine Tartrate exhibits anti-tumor activities via inducing the mitotic apoptosis, autophagy and inflammation.
Cancer Sci, 2026, 117(2):418-428
RSC Adv, 2026, 16(20):18359-18373
Commun Biol, 2025, 8(1):152
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