Microtubule Associated

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Microtubule Associated Inhibitors (22)


Cat.No. Product Name Information Product Use Citation Customer Product Validation
S1150 Paclitaxel Paclitaxel is a microtubule polymer stabilizer with IC50 of 0.1 pM in human endothelial cells.
  • Biomacromolecules, 2014, 15(11):4187-94
  • Int J Radiat Oncol, 2015, 91(4):807-16
  • Mol Pharmacol, 2014, 85(3):408-19
S1148 Docetaxel Docetaxel, an analog of taxol, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules.
  • Int J Cancer, 2015, 136(9):2065-77
  • Mol Pharm, 2014, 11(7):2040-50
  • J Transl Med, 2013, 11:204
S1241 Vincristine Vincristine is an inhibitor of polymerization of microtubules by binding to tubulin with IC50 of 32 μM.
  • Cancer Res, 2013, 73(20):6310-22
  • J Pharmacol Exp Ther, 2014, 350(3):646-56
  • Int J Mol Sci, 2012, 13(9):10736-49
S1364 Epothilone B (EPO906, Patupilone) Epothilone B is a Taxol-like microtubule-stabilizing agent with EC0.01 of 1.8 μM. Phase 2.
S1165 ABT-751 (E7010) ABT-751 (E7010) binds to the colchicine site on β-tubulin and inhibits polymerization of microtubules, not a substrate for the MDR transporter and is active against cell lines resistant to vincristine, doxorubicin, and cisplatin. Phase 1/2.
  • Bioorg Med Chem, 2013, 21(4):922-31
S7787 Docetaxel Trihydrate Docetaxel, an analog of taxol, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules.
S7495 TAI-1 TAI-1 is a potent and specific Hec1 inhibitor, which disrupts Hec1-Nek2 protein interaction.
S7494 INH6 INH6 is a potent Hec1 inhibitor, which specifically disrupts the Hec1/Nek2 interaction and causes chromosome mis-alignment.
S7493 INH1 INH1 is a cell-permeable Hec1 inhibitor, which specifically disrupts the Hec1/Nek2 interaction.
S4269 Vinorelbine Tartrate Vinorelbine Tartrate is a semi-synthetic vinca alkaloid, and inhibits mitosis through interaction with tubulin.
S7497 CK-636 CK-636 is an Arp2/3 complex inhibitor with IC50 of 4 μM, 24 μM and 32 μM for inhibition of actin polymerization induced by human, fission yeast and bovine Arp2/3 complex, respectively.
S7336 CW069 CW069 is an allosteric, and selective inhibitor of microtubule motor protein HSET with IC50 of 75 μM, significant selectivity over KSP.
S2775 Nocodazole Nocodazole is a rapidly-reversible inhibitor of microtubule polymerization, also inhibits Abl, Abl(E255K) and Abl(T315I) with IC50 of 0.21 μM, 0.53 μM and 0.64 μM, respectively.
S3022 Cabazitaxel Cabazitaxel (XRP6258) is a semi-synthetic derivative of a natural taxoid.
S7204 Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium is the water-soluble prodrug of Combretastatin A4 (CA4), which is a microtubule-targeting agent that binds β-tubulin with Kd of 0.4 μM. Fosbretabulin Disodium inhibits the polymerization of tubulin with IC50 of 2.4 μM, and also disrupts tumor vasculature. Phase 3.
S1297 Epothilone A Epothilone A is a Taxol-like microtubule-stabilizing agent with EC0.01 of 2 μM.
S1640 Albendazole Albendazole is a member of the benzimidazole compounds used as a drug indicated for the treatment of a variety of worm infestations.
S1248 Vinblastine Vinblastine inhibits microtubule formation and suppresses nAChR activity with IC50 of 8.9 μM, used to treat certain kinds of cancer.
S2195 CYT997 (Lexibulin) CYT997 (Lexibulin) is a potent microtubule polymerization inhibitor with IC50 of 10-100 nM in cancer cell lines. Phase 2.
  • Exp Ther Med, 2013, 6(2):299-304
S4071 Griseofulvin Griseofulvin, a production from some strains of the mold Penicillium griseofulvumam, is able to inhibit cell mitosis by interfering with microtubule function.
S4114 Triclabendazole Triclabendazole is a benzimidazole, it binds to tubulin impairing intracellular transport mechanisms and interferes with protein synthesis.
S2209 Vinflunine Tartrate Vinflunine is a new vinca alkaloid uniquely fluorinated with the properties of mitotic-arresting and tubulin-interacting activity. Phase 3.

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