Vincristine sulfate

Catalog No.S1241 Synonyms: Leurocristine

Vincristine sulfate Chemical Structure

Molecular Weight(MW): 923.04

Vincristine sulfate is an inhibitor of polymerization of microtubules by binding to tubulin with IC50 of 32 μM in a cell-free assay.

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  • Plk inhibitor cooperates with chemotherapeutic agents. Conditional patched mutant tumor cells were treated with increasing concentrations of the chemotherapeutic agents vincristine alone or in combination with 10 nMol/L BI-2536. Cells were cultured for 48 hours, pulsed with 3H-Td, and harvested for analysis of 3H-Td incorporation at 66 hours.

    Cancer Research, 2013, 73(20): 6310-22 . Vincristine sulfate purchased from Selleck.

    for HXO-RB44 cells, IC50 values for VCR were changed in the different SG600 treatment groups. The results are representative of three independent  experiments and of f our replicates in each experiment.

    Int J Mol Sci 2012 13, 10736-10749 . Vincristine sulfate purchased from Selleck.

Purity & Quality Control

Choose Selective Microtubule Associated Inhibitors

Biological Activity

Description Vincristine sulfate is an inhibitor of polymerization of microtubules by binding to tubulin with IC50 of 32 μM in a cell-free assay.
Targets
Microtubules [1]
(Cell-free assay)
32 μM
In vitro

Vincristine inhibits net addition of tubulin dimers at assembly ends of steady-state microtubules with Ki of 85 nM. [1] At low concentrations, Vincristine stabilizes the spindle apparatus resulting in failure of the chromosomes to segregate leading to metaphase arrest and inhibition of mitosis. At higher concentrations, Vincristine may disrupt and induce total depolymerization of microtubules. [2] Vincristine induces apoptosis in tumor cells and inhibits SH-SY5Y cell proliferation with IC50 of 0.1 μM. Vincristine induces mitotic arrest and promots the expression of caspase-3 and -9 and cyclin B, while decreasing the expression of cyclin D. [4] Vincristine induced neurotoxicity is caused by interference with microtubule function, which results in blockage of axonal transport and thus in axonal degeneration. [5]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HepG2.2.15 NGjGWnBE\WyuIG\pZYJqdGm2eTDBd5NigQ>? MmjGNE0xNjVizszN M2K0eFI1KGh? NVzEbmpP\GWlcnXhd4V{KGOnbHygeoli[mmuaYT5JIRwe2ViZHXw[Y5l\W62bIm= NYHxeG1zOjV4NkO3Olk>
HepG2-HBV1.1 NGfiPZVCeG:ydH;zbZMhSXO|YYm= NUDlRnRTOC1yLkWg{txO MWWyOEBp NYXzNVZYcW6mdXPld{BieG:ydH;zbZMh\G:|ZTDk[ZBmdmSnboTsfS=> MXKyOVY3Ozd4OR?=
HepG2.2.15 NW\Fc|JuTnWwY4Tpc44hSXO|YYm= M4nocFAvOSEQvF2= MWqyOEBp MVjwdo9ud3SnczDo[ZBifGm2aYOgRkB3cXK3czDwdo91\WmwIHX4dJJme3Orb36= MWqyOVY3Ozd4OR?=
HepG2-HBV1.1 NVLnXmlsTnWwY4Tpc44hSXO|YYm= NF;ie3ExNjFizszN M1TFbFI1KGh? MX;wdo9ud3SnczDo[ZBifGm2aYOgRkB3cXK3czDwdo91\WmwIHX4dJJme3Orb36= MlnmNlU3PjN5Nkm=
HepG2-HBV1.1 M3X3dmZ2dmO2aX;uJGF{e2G7 NFvZWWwxNjFizszN MXG0PEBp M3PWXZBzd22xdHXzJINmdGxiZYjjdoV1cW:wIH;mJIhmeGG2aYTpd{BDKH[rcoXzJI52[2ynb3PhdJNq\HNiaX7zeIVi\CCxZjDo[ZBifGm2aYOgRkB3cXK3czDEZY5mKHCjcoTpZ4xmew>? NWCxU4lDOjV4NkO3Olk>
HepG2-HBV1.1 NFvhc2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1rNSVAvOSEQvF2= M1\nO|EuPSCm Ml;rbY5pcWKrdIOgeIhmKHC{b3zp[oVz[XSrb36geIlu\SCmZYDlcoRmdnSueR?= NEf5[WMzPTZ4M{e2PS=>
HepG2-HBV1.1 M1HWcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWHVRVJ6OC5zIN88US=> Mki4NU02KGR? NVH0Uod4cW6qaXLpeJMhfGinIIDyc4xq\mW{YYTpc44hfGmvZTDk[ZBmdmSnboTsfS=> NVS1cHJNOjV4NkO3Olk>
HepG2-HBV1.1 M{jWd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX[wMlEh|ryP NYPxWYhPOTJvN{KgbC=> M4jLfIlv\HWlZYOgZ4VtdCCleXPs[UBienKnc4SgZZQhWy2yaHHz[S=> NEnI[lEzPTZ4M{e2PS=>
HepG2-HBV1.1 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHrBWmgxNjFizszN NEDmfmQyOi15MjDo NWXKTYNvcW6mdXPld{Bk\WyuIHP5Z4xmKGG{cnXzeEBifCCVLYDoZZNm MYqyOVY3Ozd4OR?=
Raji M3:zUGZ2dmO2aX;uJGF{e2G7 NHz4UmUxNjYEoN88US=> MmrXO|IhcA>? NInIV25i[m:uaYPo[ZMh[XW2b4DoZYd6yqB? NIXFSHIzPTR2NkO3Oy=>
SK-MEL-28  NGjzWHBHfW6ldHnvckBCe3OjeR?= MYmzNEBvVQ>? MWG2JIg> Mny1bY5lfWOnczDHNwKBm01iY3XscE1kgWOuZTDhdpJme3R? MVmyOVMyOzBzMB?=
H157 NWXOXHlET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3fIUGlEPTB;MT6wN{DDuSByLkC0JI1qfTKP M3jTSlI2OjV5OUGx
Jurkat NFKzVGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\DVG0yNTNibl2= NI\mVWw1QMLiaB?= MoXVSG1UVw>? MYLk[YNz\WG|ZYOgeoli[mynIHPlcIwhdnWvYnXyd{Bld3OnIHTldIVv\GWwdHz5 M4fTSFI2OTV4MUS2
CEM NHT6XGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXqxMVMhdk1? NYDETpBWPDkEoHi= Ml3MSG1UVw>? MYPk[YNz\WG|ZYOgeoli[mynIHPlcIwhdnWvYnXyd{Bld3OnIHTldIVv\GWwdHz5 NGDsTmYzPTF3NkG0Oi=>
P12 MoHRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnzpNU0{KG6P MWe0POKhcA>? NXr6R2RCTE2VTx?= MV3k[YNz\WG|ZYOgeoli[mynIHPlcIwhdnWvYnXyd{Bld3OnIHTldIVv\GWwdHz5 MX[yOVE2PjF2Nh?=
KB M1iyO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHHsTVRKSzVyPUCuNFA1QSEEsTCwMlAxODFizszN NHfJOoYzPTB3OEWyOi=>
KBv200 (ABCB1) Ml\1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTBwM{S2NkDDuSByLkCwOlYh|ryP NET4XYIzPTB3OEWyOi=>
SUDHL6  NULLZ2JHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHPMSHYy6oDLzszN NIrvVlk1QC95MjDo MkPWbY5pcWKrdIOgZ4VtdCC4aXHibYxqfHlic3nncolncWOjboTsfS=> MYKyOFk3OTZyNB?=
SUDHL6  M17yTWZ2dmO2aX;uJGF{e2G7 MkTMNgKBkc7:TR?= M{DxeVczKGh? M4ntdIlv\HWlZYOgd4lodmmoaXPhcpQh[XCxcITveIlkKG2xcoDoc4xw\3liY3jhcodmeyClb4Ty[ZN1\WRid3n0bEBDS0xzMVGgd4lTVkF? MknKNlQ6PjF4MES=
HCT-116 M4Phdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{XlbWdKPTB;NTDuUS=> M2W5RlI1QTJ5OEW3
SKNBe2C Ml\nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTN{LklCtVQvOCCwTR?= MV[yOFkzOTl{MB?=
IGNR91 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIjCR|ZKSzVyPUK0MlPDuTFwNzDuUS=> MoTNNlQ6OjF7MkC=
SKNAS MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFP5RYxKSzVyPUGuOeKyOC5{IH7N MWSyOFkzOTl{MB?=
LAN1 NH7K[nlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTJwM9MxNE4zKG6P MV[yOFkzOTl{MB?=
SHSY5Y NX72S5pPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRThwMtMxNE43KG6P M33NcFI1QTJzOUKw
A549-WT NH7pZWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTF7LkSzO{DDuSByLkW5OEAhdk1? M1m3O|I1QDV6OEK3
A549-R MofjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUW5dnZiUUN3ME2xNk4yPzhiwsGgNE4{OzNiIH7N NIfYXlQzPDh3OEiyOy=>
MCF-7-WT M37BVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTF5Lke1NkDDuSByLkKxPEAhdk1? NX;VWI9oOjR6NUi4Nlc>
MCF-7-R MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoSxTWM2OD13LkWzPUDDuSByLkG0OEAhdk1? NYexbWRPOjR6NUi4Nlc>
A549-R NYnqOJhJS3m2b4TvfIlkcXS7IFHzd4F6 Ml3DTWM2OD1zMj6xO|ghyrFiMD6zN|Mhdk1? NIj5d|EzPDh3OEiyOy=>
MCF-7-R MV3DfZRwfG:6aXPpeJkhSXO|YYm= M2HLeWlEPTB;NT61N|khyrFiMD6xOFQhdk1? M4SzXlI1QDV6OEK3
SW620 NYrMVlRWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnfsTWM2OD15LkiwJOKyKDBwMEigcm0> NY\HZ|FUOjR5Mk[3N|k>
SW620/AD300 M{\RNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkjSTWM2OD17MEmuOlAhyrFiOD65NUBvVQ>? MnXHNlQ4OjZ5M{m=
HEK293/pcDNA3.1 M3m0cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4DCPGlEPTB;MT60OUDDuSByLkKwJI5O NWDaVmVFOjR5Mk[3N|k>
HEK293/ABCC1 NXLWc4hHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M370XWlEPTB;MUmuNlkhyrFiMj6wPEBvVQ>? NG[2SogzPDd{NkezPS=>
TCC MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{S3SFI1KGh? MmHzTWM2OD15MDDuUS=> NX25OoxLOjR5MU[5OFQ>
TCC M3HGOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPTSJBvPDhiaB?= MX\JR|UxRTVyIH7N M2PhflI1PzF4OUS0
HepG2/ADM NISxfnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWDnVHNiUUN3ME2yMlc5PjQEsUCuNlM4OSEQvF2= NIHIeW0zPDdyNEW1Oi=>
HepG2 M2q2[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnLZTWM2OD1yLkCxNVXDuTBwMECxO{DPxE1? NXjMR3YxOjR5MES1OVY>
MCF-7/ADR Ml\kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTRwNEiyOuKyOC5{MEewJO69VQ>? NWDIWGRJOjR5MES1OVY>
MCF-7 M3vZVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoXLTWM2OD1yLkCxOVnDuTBwMEC2NkDPxE1? M3LtWFI1PzB2NUW2
A-172  M1rxdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXi4T2xwOC5zwrFOwG0> MlrwNlQwPzJiaB?= MkHNbY5pcWKrdIOgZ4VtdCCpcn;3eIghfGmvZTDk[ZBmdmSnboTsfS=> Mon6NlQ2OzB{M{W=
U-251MG MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIf3NlYxNjIEoN88US=> MXuyOE84OiCq M2Hw[IlvcGmkaYTzJINmdGxiZ4Lve5RpKHSrbXWg[IVx\W6mZX70cJk> MlXpNlQ2OzB{M{W=
DLD-1 NVLBUWpbTnWwY4Tpc44hSXO|YYm= MU[xNFAhdk1? M2jXT|Q5KGh? NIj6SJRxem:vb4Tld{BTXU6[MzDk[Y1mfGi7bHH0bY9vyqB? NVnGPXp3OjR2MEO0OVM>
CCD18Co MoKxSpVv[3Srb36gRZN{[Xl? NIPqUIsyODBibl2= MYe0PEBp NWHjVnJOeHKxbX;0[ZMhWlWQWEOg[IVu\XSqeXzheIlwdsLi M4DHcFI1PDB|NEWz
DLD-1 M2LnNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoK4NE0yODByIH7N M{HneVQ5KGh? NVm3XVFkcW6qaXLpeJMh[2WubDDndo94fGhiZH;z[UBl\XCnbnTlcpRtgQ>? NWXt[5NlOjR2MEO0OVM>
CCD18Co MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXTld4hYOC1zMECwJI5O NVjvT3RZPDhiaB?= M2fPbolvcGmkaYTzJINmdGxiZ4Lve5RpKGSxc3Wg[IVx\W6mZX70cJk> MX[yOFQxOzR3Mx?=
HepG2 MoPiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NILWfpYzPCCq M3TKbWlEPTB;NUKuOgKBkc7:TR?= MYiyOFM1OTZ6OB?=
HEK293/pcDNA3.1 NUfKeohST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH3Oc4hKSzVyPUCuNFA1yrFyLkCwNFMh|ryP NFLWc4czPDJ6NEe4Ny=>
HEK293/MRP1 M1HmR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnS2TWM2OD1yLkC1OeKyOC5yMUKwJO69VQ>? MnW2NlQzQDR5OEO=
Ramos MlPwRZBweHSxc3nzJGF{e2G7 M3TTdFLjiIoQvF2= NGDoPXU1QCCq MY\pcoR2[2W|IEO0MlYmyrFzLkmyKUBieG:ydH;zbZM> MWCyOFI2PjR7MR?=
NCI-H1299/pcDNA3 NULUNXllS2WubDDWbYFjcWyrdImgRZN{[Xl? NI\Lc2YxNTJyIH7N NHfBRnM6PiCq NVHre246cW6qaXLpeJMh[2WubDD2bYFjcWyrdImg[I9{\SCmZYDlcoRmdnSueR?= Mm\SNlQyPzdyMUK=
H1299/ICAM-3 NYLz[5F2S2WubDDWbYFjcWyrdImgRZN{[Xl? MmfFNE0zOCCwTR?= NH3id5A6PiCq M1TqPIlvcGmkaYTzJINmdGxidnnhZoltcXS7IHTvd4Uh\GWyZX7k[Y51dHl? NYnNb|hHOjRzN{ewNVI>
NCI-H1299/pcDNA3 MVTGeY5kfGmxbjDBd5NigQ>? M2G1W|EwPS9zMD:yNOKhdk1? M2DPfFk3KGh? NUO3fJhFcW6mdXPld{BkdGWjdnHn[UBw\iClYYPwZZNmey1|LDC4MEA6NCCjbnSgVGFTWA>? MXyyOFE4PzBzMh?=
H1299/ICAM-3 MWLGeY5kfGmxbjDBd5NigQ>? MlO0NU82NzFyL{KwxsBvVQ>? Mn30PVYhcA>? M{PmdIlv\HWlZYOgZ4xm[X[jZ3Wgc4Yh[2G|cHHz[ZMuOyxiODygPUwh[W6mIGDBVnA> NYLBSI1iOjRzN{ewNVI>
W1 M2HPfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLLfmdKSzVyPUCuNFA{OiEQvF2= MUSyOFE1ODF5Nh?=
W1VR MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{LzeGlEPTB;MD6wOVYh|ryP NEDlW|YzPDF2MEG3Oi=>
K562 M2DLWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXXJR|UxRTBwMEOyJOKyKDBwMECxJEDPxE1? MVuyOFE{PTl|Nx?=
K562/ADR NUn6UmI{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{TqNGlEPTB;Mz6yOlEhyrFiMD60NVIh|ryP MV:yOFE{PTl|Nx?=
K562 NYS1Uno5SXCxcITvd4l{KEG|c3H5 NFjlPIgxNjNizszN NIr2bmIzPCCq MUfpcoR2[2W|IHHwc5B1d3OrczDzbYdvcW[rY3HueIx6 NFXFZ3kzPDF|NUmzOy=>
K562/ADR NGXOeY5CeG:ydH;zbZMhSXO|YYm= NEexN28{KM7:TR?= NH30ZoMzPCCq NH\jcohqdmS3Y3XzJIFxd3C2b4Ppdy=> NHS5UnYzPDF|NUmzOy=>
A549 NVK4OJRMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3raemlEPTB;MD6xNEDDuSByLkCzJO69VQ>? NX\uZo81OjN7N{GwO|U>
K562 NGDPTXlE\WyuIG\pZYJqdGm2eTDBd5NigQ>? MXyzMlc26oDVNkFCpI5O NH;oWYE4OsLiaNMg NFLNSXBqdmirYnn0d{Bk\WyuII\pZYJqdGm2eTDkc5NmKGSncHXu[IVvfGy7 NEnR[2ozOzh5N{KyNy=>
lucena MmjGR4VtdCCYaXHibYxqfHliQYPzZZk> NWfBVm01Oy55NfMAl|YxyqCwTR?= M{HjcFczyqCqwrC= NFzWS3RvdyCnZn\lZ5Q> NIfrUpEzOzh5N{KyNy=>
FEPS NEjp[ldE\WyuIG\pZYJqdGm2eTDBd5NigQ>? M1;hW|MvPzYkgKO2NOKhdk1? NXr0RWlWPzMEoHlCpC=> Mluyco8h\W[oZXP0 M1rMXlI{QDd5MkKz
A2780 NVfFXXJZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF[xT45KSzVyPUOuOUBuVQ>? NVS5OlZ5OjN6MkmyNFM>
ACHN M1G0Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULGPJFSUUN3MEywMlEhdU1? MY[yN|gzQTJyMx?=
U-937 M37CVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXjIbVN[UUN3MEyzOEBvVQ>? MYOyN|gzQTJyMx?=
Jurkat MVvBdI9xfG:|aYOgRZN{[Xl? MVe1xsDPxGdxbX|CpC=> NUH5PXh2OjRiaB?= NGfkNmZqdmS3Y3XzJIFxd3C2b4Ppd{B{cWewaX\pZ4FvfGy7 MWmyN|gyODRyOR?=
Jurkat NV\NbYRWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{G0bVXDqM7:Zz;tcOKh Ml74NlQhcA>? MlXEZZJz\XO2IFr1dotifCClZXzsd{BqdiCJMj;NJJBp[XOn M3jGXVI{QDFyNEC5
Hep-2 M4j3Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEfNNWNKSzVyPUCuNFTDuTBwMEGg{txO MV2yN|c5ODR{NB?=
Hep-2/v NUjkbFdzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoTZTWM2OD1zLklCtVAvOjBizszN MXWyN|c5ODR{NB?=
SGC-7901 NVyyVJZwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVOwMVExKM7:Zz;tcC=> NEfQZXAzPC92OD:3NkBp M2DydIlvcGmkaYTzJINmdGxiZ4Lve5RpKGmwIHTvd4Uh[W6mIITpcYUh\GWyZX7k[Y51KG2jbn7ldi=> NHHVc4wzOzd2M{W3Ni=>
SGC-7901/VCR NGT5emhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV[0bY14OC1zMDFOwIcwdWx? MnL4NlQwPDhxN{KgbC=> M3;UeYlvcGmkaYTzJINmdGxiZ4Lve5RpKGmwIHTvd4Uh[W6mIITpcYUh\GWyZX7k[Y51KG2jbn7ldi=> MVuyN|c1OzV5Mh?=
SGC-7901 NYjLcXJoSXCxcITvd4l{KEG|c3H5 NGHFWm1qdmS3Y3XzJIFxd3C2b4Ppd{B{cWewaX\pZ4FvfGy7 Ml\FNlM4PDN3N{K=
SGC-7901/VCR MnrRRZBweHSxc3nzJGF{e2G7 M4[zdolv\HWlZYOgZZBweHSxc3nzJJNq\26rZnnjZY51dHl? NFy3VFAzOzd2M{W3Ni=>
KB-3-1 NYGyZ445T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF3VZ2tKSzVyPUGuOlYhyrFiMD6xOlIh|ryP NWC0RW9OOjN4N{O0OFU>
KB-C2 NUfPPJJST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnTtTWM2OD1{MEKuOVYhyrFiNEKuOFgyKM7:TR?= MnexNlM3PzN2NEW=
KB-3-1 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEHsN5FKSzVyPUGuNlYhyrFiMD6wNlch|ryP NEXseoEzOzZ5M{S0OS=>
KB-V1 MlfJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnGwTWM2OD1{MEiuPFUhyrFiMkCuOEDPxE1? MWeyN|Y4OzR2NR?=
HEK293/pcDNA3.1 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEL5[XhKSzVyPUK0MlEhyrFiMD6yNFQh|ryP M32wbVI{Pjd|NES1
HEK293/ABCB1 NVHm[2o{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI[xVZRKSzVyPUO1NVIvQCEEsTCzO|gvOzlzIN88US=> MV6yN|Y4OzR2NR?=
A549/EGFP  Mlv5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE\CTGUxNjBzLUGwNFAh|ryP NVrPXnNHUUN3ME24Ok44KMLzIEK5MlEh|ryP NH3IRoszOzZ|NEK4Ni=>
A549/Slug MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFHtcGExNjBzLUGwNFAh|ryP NHTPeVNKSzVyPUmuO{DDuSB|LkGg{txO MViyN|Y{PDJ6Mh?=
JFCR39  MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF7IcVUyKML3TR?= MkO4NlQhcA>? NGLUZ4ZFVVOR Mn\ycYFzc2WmbImgbY5kemWjc3XzJJRp\SCwdX3i[ZIhd2ZiR{KvUUBxcGG|ZTDj[Yxtew>? NILRVZQzOzV7OEK3Oi=>
A549 NU\Dc4RbTnWwY4Tpc44hSXO|YYm= NHLoNnQyODBibl2= NID3[mkyPiCq MXfEUXNQ NWfxTIJTdGWjZIOgeI8h[SCub4PzJI9nKG2rY4LveJVjfWyncx?= NGS2UlkzOzV7OEK3Oi=>
SGC7901 NGnKPG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTFwMkdihKnDueLCiUCuNVEh|rypL33s MnrQNlM2PjR2OEK=
SGC7901/LV-NC M4HPcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEnNd3JKSzVyPUGuO|fjiIoEsfMAjVAvOTZizsznM41t NHzFUnUzOzV4NES4Ni=>
SGC7901/LV-SGO1 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTRwM{dihKnDueLCiUCuN|ch|rypL33s NYqzUY1TOjN3NkS0PFI>
SGC7901/VCR M2iy[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|U{RTJyLkWz5qCKyrIkgJmxMlk3KM7:Zz;tcC=> M4j0clI{PTZ2NEiy
SGC7901/VCR-NC MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYjZdWRWUUN3ME2xPU45PuLCidMx5qCKOi5yMTFOwIcwdWx? MlH5NlM2PjR2OEK=
SGC7901/VCR-si-SGO1 NFLWT5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHnn[XRKSzVyPU[uNVjjiIoEsfMAjVEvODNizsznM41t M1OwZVI{PTZ2NEiy
SGC7901/ADR NUTSN5k3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXvIWnR4UUN3ME23Mlg26oDLwsJihKkxNjZ2IN88[{9udA>? MoLHNlM2PjR2OEK=
SGC7901/ADR-NC NXT2cHVZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYDJR|UxRThwOURihKnDueLCiUCuOlgh|rypL33s NFrLSHMzOzV4NES4Ni=>
SGC7901/ADR-si-SGO1 M{myXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml3pTWM2OD1|LkS25qCKyrIkgJmwMlI6KM7:Zz;tcC=> M3n0WVI{PTZ2NEiy
SH-SY5Y  M3TqNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVqwMlAxOS1zMDFOwG0> NYrySmtHOjRiaB?= Ml7NTWM2OD1yLkGxN:KyOC5yMUKg{txO MlrENlMyOjlyNkW=
SH-SY5Y  MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmnJNE4xODFvMUCg{txO NWLJ[|JFPDhiaB?= MkTRTWM2OD1yLkC3POKyOC5yMEmg{txO NWDaOlJFOjNzMkmwOlU>
SH-SY5Y  M3mwOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXewMlAxOS1zMDFOwG0> NHrte4g4OiCq MYjJR|UxRTBwMEWxxtExNjByODFOwG0> MYqyN|EzQTB4NR?=
SH-SY5Y M{LGVGFxd3C2b4Ppd{BCe3OjeR?= M{[yNlAvOSEQvF2= NWXFdIdoOC1{NDDo M{H4OYlv\HWlZYOgZZBweHSxc3nzJI9nKFOKLWPZOXkh[2WubIOg[o9tdG:5aX7nJINmdGxiY4njcIUh[XK{ZYP0JIF1KHSqZTDHNk9OKHCqYYPl NFfufW4zOzF{OUC2OS=>
SH-SY5Y NIniV3FCeG:ydH;zbZMhSXO|YYm= Mn7zNE4yKM7:TR?= MkPRNE0zPCCq M4Hy[Ilv\HWlZYOgcYl1d3SrYzDhdpJme3UEoB?= NYDQbWJ6OjNzMkmwOlU>

... Click to View More Cell Line Experimental Data

In vivo Vincristine (3 mg/kg) administrated by a single i.p. injection to mice bearing bilateral subcutaneous xenografts Rh12 or Rh18, induces mean growth delay of >120 and >52 day, and repopulating fractions of 0.06% and 5%, respectively. [6] Vincristine acts on subcutaneous colon 38 tumors in mice by host cell-mediated vascular effects as well as by direct tubulin-mediated cytotoxicity. Vincristine (5 mg/kg) reduces tumor blood flow of tumors by nearly 75% . [7]

Protocol

Cell Research:[1]
+ Expand
  • Cell lines: B16 melanoma cell
  • Concentrations: 10 nM
  • Incubation Time: 3 days
  • Method: Cells are plated in 2 mL of medium in 35-mm plates at a concentration of about 5 × 104 cells/mL and grow for 24 h at 37 ℃ in an atmosphere of 5% CO2 and 95% air. Then medium is replaced with fresh medium lacking or containing 4 nM drug and proliferation is continued for 3 days. Cell counts are done each day in a Coulter Counter after detaching the cells with trypsin and EDTA.
    (Only for Reference)
Animal Research:[6]
+ Expand
  • Animal Models: Human rhabdomyosarcoma xenografts Rh12
  • Formulation: Water solutioin
  • Dosages: 3 mg/kg
  • Administration: A single i.p. administration
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (108.33 mM)
Water 60 mg/mL (65.0 mM)
Ethanol Insoluble
In vivo Add solvents to the product individually and in order:
Saline
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 923.04
Formula

C46H58N4O14S

CAS No. 2068-78-2
Storage powder
Synonyms Leurocristine

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03036904 Not yet recruiting Diffuse Large B-Cell Lymphoma|High Grade B-Cell Lymphoma Weill Medical College of Cornell University|Genentech, Inc.|Massachusetts General Hospital|M.D. Anderson Cancer Center February 6, 2017 Phase 1
NCT03007147 Not yet recruiting B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1|BCR-ABL1 Fusion Protein Expression|Minimal Residual Disease|Philadelphia Chromosome Positive|T Acute Lymphoblastic Leukemia|Untreated Adult Acute Lymphoblastic Leukemia|Untreated Childhood Acute Lymphoblastic Leukemia Childrens Oncology Group|National Cancer Institute (NCI) July 2017 Phase 3
NCT03023358 Not yet recruiting Peripheral T Cell Lymphoma Nanfang Hospital of Southern Medical University February 2017 Phase 3
NCT03023046 Not yet recruiting Adult Acute Lymphoblastic Leukemia|Adult Lymphoblastic Lymphoma|CD20 Positive|Philadelphia Chromosome Positive University of Washington|National Cancer Institute (NCI) February 2017 Phase 2
NCT03003520 Recruiting Lymphoma, Large B-Cell, Diffuse Celgene February 2017 Phase 2
NCT03018626 Not yet recruiting Lymphoma, Large B-Cell, Diffuse Nanfang Hospital of Southern Medical University February 2017 Phase 3

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Frequently Asked Questions

  • Question 1:

    I want to use the product #S1421 for mouse in vivo, could you please give us your advice about administration method?

  • Answer:

    According to the reference cited on our website, we test the solubility of S1421 Staurosporine in 4% DMSO/saline, and it is a suspension at 5 mg/mL. The compound can also be dissolved in the vehicle 4% DMSO/30% PEG 300/10% Tween 80/saline at 5 mg/ml as a clear solution for injection.

Microtubule Associated Signaling Pathway Map

Related Microtubule Associated Products

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID