Vincristine sulfate

Catalog No.S1241 Synonyms: Leurocristine

Vincristine sulfate Chemical Structure

Molecular Weight(MW): 923.04

Vincristine sulfate is an inhibitor of polymerization of microtubules by binding to tubulin with IC50 of 32 μM in a cell-free assay.

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  • Plk inhibitor cooperates with chemotherapeutic agents. Conditional patched mutant tumor cells were treated with increasing concentrations of the chemotherapeutic agents vincristine alone or in combination with 10 nMol/L BI-2536. Cells were cultured for 48 hours, pulsed with 3H-Td, and harvested for analysis of 3H-Td incorporation at 66 hours.

    Cancer Research, 2013, 73(20): 6310-22 . Vincristine sulfate purchased from Selleck.

    for HXO-RB44 cells, IC50 values for VCR were changed in the different SG600 treatment groups. The results are representative of three independent  experiments and of f our replicates in each experiment.

    Int J Mol Sci 2012 13, 10736-10749 . Vincristine sulfate purchased from Selleck.

Purity & Quality Control

Choose Selective Microtubule Associated Inhibitors

Biological Activity

Description Vincristine sulfate is an inhibitor of polymerization of microtubules by binding to tubulin with IC50 of 32 μM in a cell-free assay.
Targets
Microtubules [1]
(Cell-free assay)
32 μM
In vitro

Vincristine inhibits net addition of tubulin dimers at assembly ends of steady-state microtubules with Ki of 85 nM. [1] At low concentrations, Vincristine stabilizes the spindle apparatus resulting in failure of the chromosomes to segregate leading to metaphase arrest and inhibition of mitosis. At higher concentrations, Vincristine may disrupt and induce total depolymerization of microtubules. [2] Vincristine induces apoptosis in tumor cells and inhibits SH-SY5Y cell proliferation with IC50 of 0.1 μM. Vincristine induces mitotic arrest and promots the expression of caspase-3 and -9 and cyclin B, while decreasing the expression of cyclin D. [4] Vincristine induced neurotoxicity is caused by interference with microtubule function, which results in blockage of axonal transport and thus in axonal degeneration. [5]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HepG2.2.15 MWTD[YxtKF[rYXLpcIl1gSCDc4PhfS=> M{jtO|AuOC53IN88US=> NWPoenlNOjRiaB?= NYjIUJQ2\GWlcnXhd4V{KGOnbHygeoli[mmuaYT5JIRwe2ViZHXw[Y5l\W62bIm= M37EcFI2PjZ|N{[5
HepG2-HBV1.1 NUjEU4JlSXCxcITvd4l{KEG|c3H5 NUDmPHlEOC1yLkWg{txO MmjqNlQhcA>? NX;YTIQ{cW6mdXPld{BieG:ydH;zbZMh\G:|ZTDk[ZBmdmSnboTsfS=> NX3uTZFsOjV4NkO3Olk>
HepG2.2.15 M2S5RmZ2dmO2aX;uJGF{e2G7 NV;OdopSOC5zIN88US=> MWKyOEBp MkfzdJJwdW:2ZYOgbIVx[XSrdHnzJGIhfmm{dYOgdJJwfGWrbjDlfJBz\XO|aX;u MXiyOVY3Ozd4OR?=
HepG2-HBV1.1 NIPa[GlHfW6ldHnvckBCe3OjeR?= M2\ENVAvOSEQvF2= MWKyOEBp NUHJXnRWeHKxbX;0[ZMhcGWyYYTpeIl{KEJidnnyeZMheHKxdHXpckBmgHC{ZYPzbY9v MYGyOVY3Ozd4OR?=
HepG2-HBV1.1 MVvGeY5kfGmxbjDBd5NigQ>? NIH5e4oxNjFizszN NEO1d2Y1QCCq M4fxOZBzd22xdHXzJINmdGxiZYjjdoV1cW:wIH;mJIhmeGG2aYTpd{BDKH[rcoXzJI52[2ynb3PhdJNq\HNiaX7zeIVi\CCxZjDo[ZBifGm2aYOgRkB3cXK3czDEZY5mKHCjcoTpZ4xmew>? Moi2NlU3PjN5Nkm=
HepG2-HBV1.1 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1XMeVAvOSEQvF2= MU[xMVUh\A>? MULpcohq[mm2czD0bIUheHKxbHnm[ZJifGmxbjD0bY1mKGSncHXu[IVvfGy7 MXSyOVY3Ozd4OR?=
HepG2-HBV1.1 MlPoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGnLUVcxNjFizszN M4\hV|EuPSCm MnLnbY5pcWKrdIOgeIhmKHC{b3zp[oVz[XSrb36geIlu\SCmZYDlcoRmdnSueR?= MV[yOVY3Ozd4OR?=
HepG2-HBV1.1 M1L6UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHH4emExNjFizszN M13BeFEzNTd{IHi= M{jscIlv\HWlZYOgZ4VtdCCleXPs[UBienKnc4SgZZQhWy2yaHHz[S=> M4fjUlI2PjZ|N{[5
HepG2-HBV1.1 M2n3Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF7lWFQxNjFizszN NWKwdJZ3OTJvN{KgbC=> MUjpcoR2[2W|IHPlcIwh[3mlbHWgZZJz\XO2IHH0JHMueGijc3W= MofZNlU3PjN5Nkm=
Raji M3zzfGZ2dmO2aX;uJGF{e2G7 MYSwMlXDqM7:TR?= MljPO|IhcA>? MXLhZo9tcXOqZYOgZZV1d3CqYXf5xsA> NYXJOHJKOjV2NE[zO|c>
SK-MEL-28  Mn[5SpVv[3Srb36gRZN{[Xl? M{n1SFMxKG6P NG\YV2E3KGh? MYHpcoR2[2W|IFey5qCUVSClZXzsMYN6[2ynIHHydoV{fA>? MoLhNlU{OTNyMUC=
H157 NIrSeWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmnwTWM2OD1zLkCzJOKyKDBwMESgcYl2Ok1? NHSwW4MzPTJ3N{mxNS=>
Jurkat M{\hZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHTCeVQyNTNibl2= M17QeVQ5yqCq NUHBUZdQTE2VTx?= MUXk[YNz\WG|ZYOgeoli[mynIHPlcIwhdnWvYnXyd{Bld3OnIHTldIVv\GWwdHz5 NXPvbY9zOjVzNU[xOFY>
CEM M3faSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmjoNU0{KG6P M2TPPVQ5yqCq M1jpNWROW09? MVrk[YNz\WG|ZYOgeoli[mynIHPlcIwhdnWvYnXyd{Bld3OnIHTldIVv\GWwdHz5 NX7GfmhVOjVzNU[xOFY>
P12 NVnmXWJ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vCZlEuOyCwTR?= NEDRemw1QMLiaB?= NEfMeJFFVVOR NULZR|Ix\GWlcnXhd4V{KH[rYXLs[UBk\WyuIH71cYJmenNiZH;z[UBl\XCnbnTlcpRtgQ>? MXuyOVE2PjF2Nh?=
KB NFX6R4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXS3dJRtUUN3ME2wMlAxPDliwsGgNE4xODBzIN88US=> MkLuNlUxPTh3Mk[=
KBv200 (ABCB1) MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHXOe|lKSzVyPUCuN|Q3OiEEsTCwMlAxPjZizszN M2nKOlI2ODV6NUK2
SUDHL6  MoDiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVux5qCK|ryP NWHrd4JGPDhxN{KgbC=> MmT0bY5pcWKrdIOgZ4VtdCC4aXHibYxqfHlic3nncolncWOjboTsfS=> M1O2clI1QTZzNkC0
SUDHL6  NVvi[pZkTnWwY4Tpc44hSXO|YYm= MnHNNgKBkc7:TR?= NWDBTXh7PzJiaB?= NUnoNZJbcW6mdXPld{B{cWewaX\pZ4FvfCCjcH;weI91cWNibX;ydIhwdG:peTDjbIFv\2W|IHPveJJme3SnZDD3bZRpKEKFTEGxRUB{cVKQQR?= NGroXJAzPDl4MU[wOC=>
HCT-116 Ml;yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLHTVUxRTVibl2= M4TLNVI1QTJ5OEW3
SKNBe2C NIO4fFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{PnV2lEPTB;M{KuPOKyPC5yIH7N M4jlOFI1QTJzOUKw
IGNR91 MkDYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3rIZmlEPTB;MkSuN:KyOS55IH7N NHK5eFIzPDl{MUmyNC=>
SKNAS NHfPc2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljzTWM2OD1zLkZCtVAvOiCwTR?= Mn\hNlQ6OjF7MkC=
LAN1 NUDYUpp1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFewUWVKSzVyPUKuN:KyOC5{IH7N NGf4RVEzPDl{MUmyNC=>
SHSY5Y MoXWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn;KTWM2OD16LkNCtVAvPiCwTR?= NGXN[WUzPDl{MUmyNC=>
A549-WT Ml[zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\YTWM2OD1zOT60N|chyrFiMD61PVQhKG6P MU[yOFg2QDh{Nx?=
A549-R MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVW3ellQUUN3ME2xNk4yPzhiwsGgNE4{OzNiIH7N M4rpTVI1QDV6OEK3
MCF-7-WT NI\tO5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MluxTWM2OD1zNz63OVIhyrFiMD6yNVghKG6P MXWyOFg2QDh{Nx?=
MCF-7-R NFLRZXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTVwNUO5JOKyKDBwMUS0JEBvVQ>? MUOyOFg2QDh{Nx?=
A549-R M3;kW2N6fG:2b4jpZ4l1gSCDc4PhfS=> Mnr4TWM2OD1zMj6xO|ghyrFiMD6zN|Mhdk1? MW[yOFg2QDh{Nx?=
MCF-7-R NGfVelhEgXSxdH;4bYNqfHliQYPzZZk> M1TGUmlEPTB;NT61N|khyrFiMD6xOFQhdk1? MnTPNlQ5PTh6Mke=
SW620 NG[0WJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXe2[mxlUUN3ME23MlgxKMLzIECuNFghdk1? MnrWNlQ4OjZ5M{m=
SW620/AD300 NXnMWmlPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGTZVFlKSzVyPUmwPU43OCEEsTC4MlkyKG6P MVGyOFczPjd|OR?=
HEK293/pcDNA3.1 MnfkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkTzTWM2OD1zLkS1JOKyKDBwMkCgcm0> MmXQNlQ4OjZ5M{m=
HEK293/ABCC1 NVrQXpFWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIXCeZdKSzVyPUG5MlI6KMLzIEKuNFghdk1? MXSyOFczPjd|OR?=
TCC MlLQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVGyOEBp NYrXcnduUUN3ME23NEBvVQ>? MYiyOFcyPjl2NB?=
TCC M{DONGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGL5XXc1QCCq MkPhTWM2OD13MDDuUS=> MXOyOFcyPjl2NB?=
HepG2/ADM MofPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWWz[Yc5UUN3ME2yMlc5PjQEsUCuNlM4OSEQvF2= MYCyOFcxPDV3Nh?=
HepG2 NU\J[WJyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoTJTWM2OD1yLkCxNVXDuTBwMECxO{DPxE1? NXK3R|hVOjR5MES1OVY>
MCF-7/ADR MlzQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3LyXmlEPTB;ND60PFI3yrFyLkKwO|Ah|ryP MUOyOFcxPDV3Nh?=
MCF-7 NYS5S2pWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4mwO2lEPTB;MD6wNVU6yrFyLkCwOlIh|ryP NWXXbIZLOjR5MES1OVY>
A-172  NInPelVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWDWeoVvOC5zwrFOwG0> MnmyNlQwPzJiaB?= M33ZTYlvcGmkaYTzJINmdGxiZ4Lve5RpKHSrbXWg[IVx\W6mZX70cJk> M1O5flI1PTNyMkO1
U-251MG MlzNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXOwMlHDqM7:TR?= NEHPOHczPC95MjDo MoTLbY5pcWKrdIOgZ4VtdCCpcn;3eIghfGmvZTDk[ZBmdmSnboTsfS=> NEC0eZczPDV|MEKzOS=>
DLD-1 MXHGeY5kfGmxbjDBd5NigQ>? NX;nZoZNOTByIH7N NVP2UXQ3PDhiaB?= M13NVJBzd22xdHXzJHJWVlh|IHTlcYV1cHmuYYTpc47DqA>? M33nVlI1PDB|NEWz
CCD18Co NX\NR4ZYTnWwY4Tpc44hSXO|YYm= MWexNFAhdk1? NGrzcFc1QCCq MlLsdJJwdW:2ZYOgVnVPYDNiZHXt[ZRpgWyjdHnvcuKh NVy0fYJYOjR2MEO0OVM>
DLD-1 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlzLNE0yODByIH7N Ml;3OFghcA>? MXHpcohq[mm2czDj[YxtKGe{b4f0bEBld3OnIHTldIVv\GWwdHz5 MlfWNlQ1ODN2NUO=
CCD18Co M3XnSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYG2bnJNOC1zMECwJI5O MmX4OFghcA>? MkH3bY5pcWKrdIOgZ4VtdCCpcn;3eIgh\G:|ZTDk[ZBmdmSnboTsfS=> NGfCXo0zPDRyM{S1Ny=>
HepG2 M1:zdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV:yOEBp NFzFb49KSzVyPUWyMlXjiIoQvF2= MXmyOFM1OTZ6OB?=
HEK293/pcDNA3.1 NV3OSoxDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4PNWGlEPTB;MD6wNFTDuTBwMECwN{DPxE1? MVKyOFI5PDd6Mx?=
HEK293/MRP1 MnjNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV;vc4REUUN3ME2wMlA2PcLzMD6wNVIxKM7:TR?= Mn3YNlQzQDR5OEO=
Ramos NFj5PI1CeG:ydH;zbZMhSXO|YYm= NVfiZ|B4OuLCid88US=> MX60PEBp MVHpcoR2[2W|IEO0MlYmyrFzLkmyKUBieG:ydH;zbZM> NVzxO|ZOOjR{NU[0PVE>
NCI-H1299/pcDNA3 NVHZO2s4S2WubDDWbYFjcWyrdImgRZN{[Xl? M4rUNlAuOjBibl2= MXW5OkBp MULpcohq[mm2czDj[YxtKH[rYXLpcIl1gSCmb4PlJIRmeGWwZHXueIx6 MUeyOFE4PzBzMh?=
H1299/ICAM-3 NX;6eZo3S2WubDDWbYFjcWyrdImgRZN{[Xl? Mln2NE0zOCCwTR?= Mn\qPVYhcA>? NUPaWWJycW6qaXLpeJMh[2WubDD2bYFjcWyrdImg[I9{\SCmZYDlcoRmdnSueR?= M4W4V|I1OTd5MEGy
NCI-H1299/pcDNA3 MXTGeY5kfGmxbjDBd5NigQ>? Mnj5NU82NzFyL{KwxsBvVQ>? NFqxem86PiCq M3nLW4lv\HWlZYOgZ4xm[X[jZ3Wgc4Yh[2G|cHHz[ZMuOyxiODygPUwh[W6mIGDBVnA> NF70NYszPDF5N{CxNi=>
H1299/ICAM-3 NUTjfI54TnWwY4Tpc44hSXO|YYm= MU[xM|UwOTBxMkFCpI5O Mo[zPVYhcA>? MXjpcoR2[2W|IHPs[YF3[WenIH;mJINie3Cjc3XzMVMtKDhuIEmsJIFv\CCSQWLQ M3LtRVI1OTd5MEGy
W1 NEjqWnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYfHeG11UUN3ME2wMlAxOzJizszN MmHsNlQyPDBzN{[=
W1VR M4\zSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{W5cWlEPTB;MD6wOVYh|ryP NUTVXZVWOjRzNECxO|Y>
K562 MknGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkDpTWM2OD1yLkCzNkDDuSByLkCwNUAh|ryP NGqwWngzPDF|NUmzOy=>
K562/ADR NHK2RohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUG2UGNyUUN3ME2zMlI3OSEEsTCwMlQyOiEQvF2= M{Kwb|I1OTN3OUO3
K562 M36xcWFxd3C2b4Ppd{BCe3OjeR?= NVfP[5NpOC5|IN88US=> MlX6NlQhcA>? Mm\SbY5lfWOnczDhdI9xfG:|aYOgd4lodmmoaXPhcpRtgQ>? M3HsXVI1OTN3OUO3
K562/ADR NF\sVoNCeG:ydH;zbZMhSXO|YYm= NI\TbXo{KM7:TR?= MVWyOEBp NFnKNHNqdmS3Y3XzJIFxd3C2b4Ppdy=> NFTyS4gzPDF|NUmzOy=>
A549 MlniS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTBwMUCgxtEhOC5yMzFOwG0> MWOyN|k4OTB5NR?=
K562 NFHLUVJE\WyuIG\pZYJqdGm2eTDBd5NigQ>? MYKzMlc26oDVNkFCpI5O M33aVFczyqCqwrC= MVrpcohq[mm2czDj[YxtKH[rYXLpcIl1gSCmb4PlJIRmeGWwZHXueIx6 MlLLNlM5Pzd{MkO=
lucena M3;CT2NmdGxiVnnhZoltcXS7IFHzd4F6 NEHVdo4{Njd34pETOlDDqG6P MoGwO|LDqGkEoB?= Ml3Kco8h\W[oZXP0 M{XxfVI{QDd5MkKz
FEPS NYLuXopvS2WubDDWbYFjcWyrdImgRZN{[Xl? MkLYN{44PeLCk{[wxsBvVQ>? M2X3PVczyqCqwrC= MmHHco8h\W[oZXP0 MViyN|g4PzJ{Mx?=
A2780 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\KZ4lKSzVyPUOuOUBuVQ>? MlTBNlM5Ojl{MEO=
ACHN NFHZdphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRDBwMTDtUS=> MlzDNlM5Ojl{MEO=
U-937 MmD4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NELrbFVKSzVyPEO0JI5O MYOyN|gzQTJyMx?=
Jurkat NFrBWZhCeG:ydH;zbZMhSXO|YYm= M1XU[|XDqM7:Zz;tcOKh M{XtW|I1KGh? MUnpcoR2[2W|IHHwc5B1d3OrczDzbYdvcW[rY3HueIx6 NFezSIMzOzhzMESwPS=>
Jurkat MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXG1xsDPxGdxbX|CpC=> MWqyOEBp MXThdpJme3RiSoXyb4F1KGOnbHzzJIlvKEd{L12gdIhie2V? M4rHSlI{QDFyNEC5
Hep-2 NXnrU40zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFTuOZlKSzVyPUCuNFTDuTBwMEGg{txO NU\1OYRDOjN5OEC0NlQ>
Hep-2/v NYq2fGV[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkfDTWM2OD1zLklCtVAvOjBizszN MoDrNlM4QDB2MkS=
SGC-7901 Ml3SS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWWwMVExKM7:Zz;tcC=> M1vnelI1NzR6L{eyJIg> MX3pcohq[mm2czDj[YxtKGe{b4f0bEBqdiCmb4PlJIFv\CC2aX3lJIRmeGWwZHXueEBu[W6wZYK= MWqyN|c1OzV5Mh?=
SGC-7901/VCR NITqZ5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV:wMVExKM7:Zz;tcC=> MX6yOE81QC95MjDo M1rObIlvcGmkaYTzJINmdGxiZ4Lve5RpKGmwIHTvd4Uh[W6mIITpcYUh\GWyZX7k[Y51KG2jbn7ldi=> M3rafFI{PzR|NUey
SGC-7901 MYLBdI9xfG:|aYOgRZN{[Xl? Mof4bY5lfWOnczDhdI9xfG:|aYOgd4lodmmoaXPhcpRtgQ>? NV3MfYhIOjN5NEO1O|I>
SGC-7901/VCR NYDJdlhDSXCxcITvd4l{KEG|c3H5 NXnW[4JrcW6mdXPld{BieG:ydH;zbZMhe2mpbnnmbYNidnSueR?= NHTGeGMzOzd2M{W3Ni=>
KB-3-1 NHy5S5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\scldKSzVyPUGuOlYhyrFiMD6xOlIh|ryP NHvOdVEzOzZ5M{S0OS=>
KB-C2 NUiwU2ZwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVvPdHU2UUN3ME2yNFIvPTZiwsGgOFIvPDhzIN88US=> M2rDWlI{Pjd|NES1
KB-3-1 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlXLTWM2OD1zLkK2JOKyKDBwMEK3JO69VQ>? MUGyN|Y4OzR2NR?=
KB-V1 NXPaV5dDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXqzNGdTUUN3ME2yNFgvQDViwsGgNlAvPCEQvF2= Ml73NlM3PzN2NEW=
HEK293/pcDNA3.1 Mnj1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFfBU2pKSzVyPUK0MlEhyrFiMD6yNFQh|ryP M{fmXlI{Pjd|NES1
HEK293/ABCB1 NH24UVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUjNVpRLUUN3ME2zOVEzNjhiwsGgN|c5NjN7MTFOwG0> M4f1SlI{Pjd|NES1
A549/EGFP  NVjOWpQyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;BUFAvODFvMUCwNEDPxE1? M3vRVmlEPTB;OE[uO{DDuSB{OT6xJO69VQ>? NHXn[2szOzZ|NEK4Ni=>
A549/Slug NIHPd45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\ENZYxOC5yMT2xNFAxKM7:TR?= M2PSPWlEPTB;OT63JOKyKDNwMTFOwG0> M{LpelI{PjN2Mkiy
JFCR39  NEPjc2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXZNlAyKML3TR?= NHLJXYczPCCq MmrLSG1UVw>? MnLScYFzc2WmbImgbY5kemWjc3XzJJRp\SCwdX3i[ZIhd2ZiR{KvUUBxcGG|ZTDj[Yxtew>? NIW4UIEzOzV7OEK3Oi=>
A549 M4jBS2Z2dmO2aX;uJGF{e2G7 NHzSNWsyODBibl2= MmfNNVYhcA>? M{P2WGROW09? NHTHbIdt\WGmczD0c{BiKGyxc4Ogc4YhdWmlcn;0eYJ2dGW| NHjST|IzOzV7OEK3Oi=>
SGC7901 M1mwemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\PO3k5UUN3ME2xMlI36oDLwsJihKkxNjFzIN88[{9udA>? NX\ac41tOjN3NkS0PFI>
SGC7901/LV-NC NITaZVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFXoXoZKSzVyPUGuO|fjiIoEsfMAjVAvOTZizsznM41t NXu0WJh[OjN3NkS0PFI>
SGC7901/LV-SGO1 NELzXnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3MXnJKSzVyPUSuN|bjiIoEsfMAjVAvOzdizsznM41t NXvhTIk3OjN3NkS0PFI>
SGC7901/VCR NXXQd2Z4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4\Je2lEPTN;MkCuOVPjiIoEsfMAjVEvQTZizsznM41t NHTKcZUzOzV4NES4Ni=>
SGC7901/VCR-NC NIjwb3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHW1UZNKSzVyPUG5Mlg36oDLwsJihKkzNjBzIN88[{9udA>? NVrjdGdVOjN3NkS0PFI>
SGC7901/VCR-si-SGO1 NXzwV2dqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjCTWM2OD14LkG45qCKyrIkgJmxMlA{KM7:Zz;tcC=> M3rob|I{PTZ2NEiy
SGC7901/ADR Mmj4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1fw[GlEPTB;Nz64OgKBkcLz4pEJNE43PCEQvHevcYw> MkPVNlM2PjR2OEK=
SGC7901/ADR-NC NFTwe|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRThwOURihKnDueLCiUCuOlgh|rypL33s NWPJb5Q{OjN3NkS0PFI>
SGC7901/ADR-si-SGO1 NGnjUXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1jBeGlEPTB;Mz60OwKBkcLz4pEJNE4zQSEQvHevcYw> MoT6NlM2PjR2OEK=
SH-SY5Y  M33oWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MojoNE4xODFvMUCg{txO Mn\XNlQhcA>? M1fiVWlEPTB;MD6xNVPDuTBwMEGyJO69VQ>? M3K2fFI{OTJ7ME[1
SH-SY5Y  M3K0fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWOwMlAxOS1zMDFOwG0> MX[0PEBp MYHJR|UxRTBwMEe4xtExNjByOTFOwG0> M3WwR|I{OTJ7ME[1
SH-SY5Y  MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkfRNE4xODFvMUCg{txO M3\4PFczKGh? NHi1SoNKSzVyPUCuNFUyyrFyLkCwPEDPxE1? MmDkNlMyOjlyNkW=
SH-SY5Y M4\VRWFxd3C2b4Ppd{BCe3OjeR?= NYH3d5VrOC5zIN88US=> NIHLcYkxNTJ2IHi= NUjDSHlWcW6mdXPld{BieG:ydH;zbZMhd2ZiU1itV3k2YSClZXzsd{Bnd2yub4fpcoch[2WubDDjfYNt\SCjcoLld5Qh[XRidHjlJGczN01icHjhd4U> NUDWXGJROjNzMkmwOlU>
SH-SY5Y MYLBdI9xfG:|aYOgRZN{[Xl? NVnqdY1HOC5zIN88US=> MnLqNE0zPCCq MXLpcoR2[2W|IH3peI91cWNiYYLy[ZN1yqB? MV6yN|EzQTB4NR?=

... Click to View More Cell Line Experimental Data

In vivo Vincristine (3 mg/kg) administrated by a single i.p. injection to mice bearing bilateral subcutaneous xenografts Rh12 or Rh18, induces mean growth delay of >120 and >52 day, and repopulating fractions of 0.06% and 5%, respectively. [6] Vincristine acts on subcutaneous colon 38 tumors in mice by host cell-mediated vascular effects as well as by direct tubulin-mediated cytotoxicity. Vincristine (5 mg/kg) reduces tumor blood flow of tumors by nearly 75% . [7]

Protocol

Cell Research:[1]
+ Expand
  • Cell lines: B16 melanoma cell
  • Concentrations: 10 nM
  • Incubation Time: 3 days
  • Method: Cells are plated in 2 mL of medium in 35-mm plates at a concentration of about 5 × 104 cells/mL and grow for 24 h at 37 ℃ in an atmosphere of 5% CO2 and 95% air. Then medium is replaced with fresh medium lacking or containing 4 nM drug and proliferation is continued for 3 days. Cell counts are done each day in a Coulter Counter after detaching the cells with trypsin and EDTA.
    (Only for Reference)
Animal Research:[6]
+ Expand
  • Animal Models: Human rhabdomyosarcoma xenografts Rh12
  • Formulation: Water solutioin
  • Dosages: 3 mg/kg
  • Administration: A single i.p. administration
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (108.33 mM)
Water 60 mg/mL (65.0 mM)
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
Saline
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 923.04
Formula

C46H58N4O14S

CAS No. 2068-78-2
Storage powder
in solvent
Synonyms Leurocristine

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
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    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
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    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03036904 Not yet recruiting Diffuse Large B-Cell Lymphoma|High Grade B-Cell Lymphoma Weill Medical College of Cornell University|Genentech, Inc.|Massachusetts General Hospital|M.D. Anderson Cancer Center February 6, 2017 Phase 1
NCT03007147 Not yet recruiting B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1|BCR-ABL1 Fusion Protein Expression|Minimal Residual Disease|Philadelphia Chromosome Positive|T Acute Lymphoblastic Leukemia|Untreated Adult Acute Lymphoblastic Leukemia|Untreated Childhood Acute Lymphoblastic Leukemia Childrens Oncology Group|National Cancer Institute (NCI) July 2017 Phase 3
NCT03023358 Not yet recruiting Peripheral T Cell Lymphoma Nanfang Hospital of Southern Medical University February 2017 Phase 3
NCT03023046 Not yet recruiting Adult Acute Lymphoblastic Leukemia|Adult Lymphoblastic Lymphoma|CD20 Positive|Philadelphia Chromosome Positive University of Washington|National Cancer Institute (NCI) February 2017 Phase 2
NCT03003520 Recruiting Lymphoma, Large B-Cell, Diffuse Celgene February 2017 Phase 2
NCT03018626 Not yet recruiting Lymphoma, Large B-Cell, Diffuse Nanfang Hospital of Southern Medical University February 2017 Phase 3

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Frequently Asked Questions

  • Question 1:

    I want to use the product #S1421 for mouse in vivo, could you please give us your advice about administration method?

  • Answer:

    According to the reference cited on our website, we test the solubility of S1421 Staurosporine in 4% DMSO/saline, and it is a suspension at 5 mg/mL. The compound can also be dissolved in the vehicle 4% DMSO/30% PEG 300/10% Tween 80/saline at 5 mg/ml as a clear solution for injection.

Microtubule Associated Signaling Pathway Map

Related Microtubule Associated Products

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID