Research Area
Product Type
United States ( Change Country )
Vincristine Chemical Structure
Recommended Products
Docetaxel (Taxotere)
Docetaxel (Taxotere) is an microtubule disassembly inhibitor with IC50 of a range of 0.31-100 ηM.
Paclitaxel (Taxol)
Paclitaxel also known as Taxol, Onxol, Nov-Onxol is a microtubule polymer stabilizer with an IC50 of 0.1 pM for human endothelial cells.
ABT-751
ABT-751 is a novel bioavailable tubulin-binding and antimitotic sulfonamide agent with IC50 of about 1.5 and 3.4 µM in neuroblastoma and non-neuroblastoma cell lines, respectively.
Epothilone A
Epothilone A is a new kind of microtubule function inhibitor with an IC50 of 4.4 nM for tubulin polymerization and cytotoxicity.
Epothilone B (EPO906)
Epothilone B (EPO906) is a new kind of cancer agents and microtubule function inhibitor with an IC50 of 3.5 nM.
CYT997
CYT997, a small molecule inhibits the polymerization of tubulin with an IC50 of 3 μmol/L and shows an IC50 of between 1 and 100 nmol/L across a panel of cancer cell lines.
Vinflunine Tartrate
Vinflunine Tartrate is a tartrate salt of vinflunine that is a new microtubule inhibitor agent with IC50 of 18.8 nM.
ABT-888 (Veliparib)
ABT-888 (Veliparib) is a potent poly (ADP-ribose) polymerase (PARP) inhibitor of PARP-1 and PARP-2 with Ki of 5.2 nM and 2.9 nM, respectively.
Olaparib (AZD2281)
Olaparib(AZD2281, KU0059436) is a selective inhibitor of PARP-1 and PARP-2 enzymes with IC50 of 5 nM and 1 nM, respectively.
Y-27632 2HCl
Y-27632 2HCl is ROCK inhibitor, as a novel bronchodilator. Y27632 is available with IC50 of 3.3±0.25 μM and 2.8±0.2 μM in human and rabbit tissues, respectively.
Biological Activity
Vincristine Sulfate is a kind of microtubule function inhibitor with IC50 of 10.4±1.1, 28.1±3.4, 22.4±2.1 µM for HL-60, Bel7402, HO-8910, respectively. It is the sulfate salt of a natural alkaloid isolated from the plant Vinca rosea Linn with antimitotic and antineoplastic activities. Vincristine binds irreversibly to microtubules and spindle proteins in S phase of the cell cycle and interferes with the formation of the mitotic spindle, thereby arresting tumor cells in metaphase. The IC50 and IC90 of vincristine for the 4 vaccine-associated feline sarcoma (VAFS) cell lines were between 0.005 to 0.039 µg/ml and 0.045 to 1.027 µg/ml, respectively .This agent also depolymerizes microtubules and may also interfere with amino acid, cyclic AMP, and glutathione metabolism. [1][2][3]
Chemical Information
| Molecular Weight (WM): | 923.04 |
|---|---|
| Formula: | C46H58N4O14S |
| CAS No.: | 2068-78-2 |
| Synonyms: |
leurocristine, Oncovin
|
| Dissolve in (25°C): | DMSO ≥185mg/mL |
| Water ≥185mg/mL | |
| Ethanol <1mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
Quality Control & MSDS
View current batch:
Research Area
Notes:
Related Inhibitors
Recommended Screening Libraries
Chemical Library
A collection of 864 bioactive compounds
Inhibitor Library
A collection of 481 inhibitors
Kinase Inhibitor Library
A collection of 194 kinase inhibitors
Tyrosine Kinase Inhibitor Library
A collection of 85 tyrosine kinase inhibitors.
FDA Approved Drug Library
A collection of 426 FDA approved drugs
Natural Product Library
A collection of 139 natural products
Chemotherapeutic Agent Library
A collection of 40 chemotherapeutic agents
Epigenetics Compound library
A unique collection of 17 small molecule modulators
Stem Cell Compound library
A unique collection of 47 small molecule inhibitors
GPCR Compound library
A unique collection of 63 GPCR small molecules
Keywords:buy Vincristine | Vincristine supplier | purchase Vincristine | Vincristine cost | Vincristine manufacturer | order Vincristine | Vincristine distributor