Vincristine sulfate

Catalog No.S1241 Synonyms: Leurocristine

Vincristine sulfate Chemical Structure

Molecular Weight(MW): 923.04

Vincristine sulfate is an inhibitor of polymerization of microtubules by binding to tubulin with IC50 of 32 μM in a cell-free assay.

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In DMSO USD 90 In stock
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USD 270 In stock
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2 Customer Reviews

  • Plk inhibitor cooperates with chemotherapeutic agents. Conditional patched mutant tumor cells were treated with increasing concentrations of the chemotherapeutic agents vincristine alone or in combination with 10 nMol/L BI-2536. Cells were cultured for 48 hours, pulsed with 3H-Td, and harvested for analysis of 3H-Td incorporation at 66 hours.

    Cancer Research, 2013, 73(20): 6310-22 . Vincristine sulfate purchased from Selleck.

    for HXO-RB44 cells, IC50 values for VCR were changed in the different SG600 treatment groups. The results are representative of three independent  experiments and of f our replicates in each experiment.

    Int J Mol Sci 2012 13, 10736-10749 . Vincristine sulfate purchased from Selleck.

Purity & Quality Control

Choose Selective Microtubule Associated Inhibitors

Biological Activity

Description Vincristine sulfate is an inhibitor of polymerization of microtubules by binding to tubulin with IC50 of 32 μM in a cell-free assay.
Targets
Microtubules [1]
(Cell-free assay)
32 μM
In vitro

Vincristine inhibits net addition of tubulin dimers at assembly ends of steady-state microtubules with Ki of 85 nM. [1] At low concentrations, Vincristine stabilizes the spindle apparatus resulting in failure of the chromosomes to segregate leading to metaphase arrest and inhibition of mitosis. At higher concentrations, Vincristine may disrupt and induce total depolymerization of microtubules. [2] Vincristine induces apoptosis in tumor cells and inhibits SH-SY5Y cell proliferation with IC50 of 0.1 μM. Vincristine induces mitotic arrest and promots the expression of caspase-3 and -9 and cyclin B, while decreasing the expression of cyclin D. [4] Vincristine induced neurotoxicity is caused by interference with microtubule function, which results in blockage of axonal transport and thus in axonal degeneration. [5]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HepG2.2.15 NGXLV41E\WyuIG\pZYJqdGm2eTDBd5NigQ>? NVTV[Jd[OC1yLkWg{txO NVfLfWlDOjRiaB?= NGK5PGFl\WO{ZXHz[ZMh[2WubDD2bYFjcWyrdImg[I9{\SCmZYDlcoRmdnSueR?= NGnhWXYzPTZ4M{e2PS=>
HepG2-HBV1.1 NH7jfVBCeG:ydH;zbZMhSXO|YYm= MlrRNE0xNjVizszN NH[wTWEzPCCq NFzHZXNqdmS3Y3XzJIFxd3C2b4Ppd{Bld3OnIHTldIVv\GWwdHz5 MUKyOVY3Ozd4OR?=
HepG2.2.15 NV\Xfm43TnWwY4Tpc44hSXO|YYm= Mn\yNE4yKM7:TR?= MlvXNlQhcA>? NGHs[opxem:vb4Tld{Bp\XCjdHn0bZMhSiC4aYL1d{Bxem:2ZXnuJIV5eHKnc4Ppc44> MnfWNlU3PjN5Nkm=
HepG2-HBV1.1 M4GydmZ2dmO2aX;uJGF{e2G7 NYHQToh7OC5zIN88US=> MmrDNlQhcA>? Ml76dJJwdW:2ZYOgbIVx[XSrdHnzJGIhfmm{dYOgdJJwfGWrbjDlfJBz\XO|aX;u NFSwfZczPTZ4M{e2PS=>
HepG2-HBV1.1 NXX5b4FWTnWwY4Tpc44hSXO|YYm= NXW0eGFbOC5zIN88US=> NHXLcHk1QCCq MX3wdo9ud3SnczDj[YxtKGW6Y4LleIlwdiCxZjDo[ZBifGm2aYOgRkB3cXK3czDueYNt\W:lYYDzbYR{KGmwc4TlZYQhd2ZiaHXwZZRqfGm|IFKgeolzfXNiRHHu[UBx[XK2aXPs[ZM> NUS5W3pMOjV4NkO3Olk>
HepG2-HBV1.1 MkS4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVf2RVJTOC5zIN88US=> MUmxMVUh\A>? MVXpcohq[mm2czD0bIUheHKxbHnm[ZJifGmxbjD0bY1mKGSncHXu[IVvfGy7 MnnqNlU3PjN5Nkm=
HepG2-HBV1.1 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NILB[4UxNjFizszN NWnNOVZZOS13IHS= Ml60bY5pcWKrdIOgeIhmKHC{b3zp[oVz[XSrb36geIlu\SCmZYDlcoRmdnSueR?= NXHjVGMxOjV4NkO3Olk>
HepG2-HBV1.1 NEfxSoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX:wMlEh|ryP MYGxNk04OiCq M2PS[olv\HWlZYOgZ4VtdCCleXPs[UBienKnc4SgZZQhWy2yaHHz[S=> M4n2flI2PjZ|N{[5
HepG2-HBV1.1 M2Dofmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NILlVYUxNjFizszN NXXVfVc4OTJvN{KgbC=> NX;URVRocW6mdXPld{Bk\WyuIHP5Z4xmKGG{cnXzeEBifCCVLYDoZZNm MWCyOVY3Ozd4OR?=
Raji Mm\wSpVv[3Srb36gRZN{[Xl? M{jmd|AvPcLizszN MWC3NkBp NWLoTmpJ[WKxbHnzbIV{KGG3dH;wbIFogcLi MYGyOVQ1PjN5Nx?=
SK-MEL-28  NV3mNVAyTnWwY4Tpc44hSXO|YYm= MXqzNEBvVQ>? NIn2S2Y3KGh? M{L1XYlv\HWlZYOgS|LjiJOPIHPlcIwu[3mlbHWgZZJz\XO2 NGOwTG4zPTNzM{CxNC=>
H157 NGnWdFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH;IO|hKSzVyPUGuNFMhyrFiMD6wOEBucXV{TR?= NIfyd|czPTJ3N{mxNS=>
Jurkat MlKyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoHMNU0{KG6P NEjBWHg1QMLiaB?= M1HxXGROW09? NYnUe2tC\GWlcnXhd4V{KH[rYXLs[UBk\WyuIH71cYJmenNiZH;z[UBl\XCnbnTlcpRtgQ>? NUH0fWUyOjVzNU[xOFY>
CEM NUjJNmpET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2rUcFEuOyCwTR?= MUO0POKhcA>? M4XtV2ROW09? NVPE[Jk3\GWlcnXhd4V{KH[rYXLs[UBk\WyuIH71cYJmenNiZH;z[UBl\XCnbnTlcpRtgQ>? M3XBPFI2OTV4MUS2
P12 MmTwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUjzblVGOS1|IH7N NUDhRpVQPDkEoHi= MXzEUXNQ NVLVbVB3\GWlcnXhd4V{KH[rYXLs[UBk\WyuIH71cYJmenNiZH;z[UBl\XCnbnTlcpRtgQ>? MWKyOVE2PjF2Nh?=
KB MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTBwMEC0PUDDuSByLkCwNFEh|ryP M1jJeFI2ODV6NUK2
KBv200 (ABCB1) NWPi[2Q3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{\xTWlEPTB;MD6zOFYzKMLzIECuNFA3PiEQvF2= NWfURmV2OjVyNUi1NlY>
SUDHL6  MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M37NSVHjiIoQvF2= M4H6[VQ5Nzd{IHi= Mn7ZbY5pcWKrdIOgZ4VtdCC4aXHibYxqfHlic3nncolncWOjboTsfS=> NUPGOmhWOjR7NkG2NFQ>
SUDHL6  NHHtN5FHfW6ldHnvckBCe3OjeR?= NIDwbogy6oDLzszN NX3uUmRZPzJiaB?= MnGxbY5lfWOnczDzbYdvcW[rY3HueEBieG:ydH;0bYMhdW:{cHjvcI9ogSClaHHu[4V{KGOxdILld5Rm\CC5aYToJGJEVDFzQTDzbXJPSQ>? NEi4SWkzPDl4MU[wOC=>
HCT-116 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDHTVUxRTVibl2= MlftNlQ6Ojd6NUe=
SKNBe2C M1HwVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF3ZRZlKSzVyPUOyMljDuTRwMDDuUS=> MknFNlQ6OjF7MkC=
IGNR91 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTJ2LkRCtVEvPyCwTR?= MmrZNlQ6OjF7MkC=
SKNAS NHvwTZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlLYTWM2OD1zLkZCtVAvOiCwTR?= MlrXNlQ6OjF7MkC=
LAN1 M1i2cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHq2WZFKSzVyPUKuN:KyOC5{IH7N MUeyOFkzOTl{MB?=
SHSY5Y MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXj0UYI1UUN3ME24MlLDuTBwNjDuUS=> MV6yOFkzOTl{MB?=
A549-WT M{jXSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\MZW5CUUN3ME2xPU41OzdiwsGgNE42QTRiIH7N NVLC[3piOjR6NUi4Nlc>
A549-R NHnnXYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWnXSpVVUUN3ME2xNk4yPzhiwsGgNE4{OzNiIH7N MYKyOFg2QDh{Nx?=
MCF-7-WT NIjI[opIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXTqN3dUUUN3ME2xO{44PTJiwsGgNE4zOThiIH7N M3fCNVI1QDV6OEK3
MCF-7-R MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\JR|UxRTVwNUO5JOKyKDBwMUS0JEBvVQ>? M2DlelI1QDV6OEK3
A549-R M{\u[2N6fG:2b4jpZ4l1gSCDc4PhfS=> MUXJR|UxRTF{LkG3PEDDuSByLkOzN{BvVQ>? M3vMUVI1QDV6OEK3
MCF-7-R NE\vdFJEgXSxdH;4bYNqfHliQYPzZZk> MkLJTWM2OD13LkWzPUDDuSByLkG0OEBvVQ>? MVSyOFg2QDh{Nx?=
SW620 NUfqV4ZRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mnr6TWM2OD15LkiwJOKyKDBwMEigcm0> MYeyOFczPjd|OR?=
SW620/AD300 M1\CfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4fTOWlEPTB;OUC5MlYxKMLzIEiuPVEhdk1? NV:2N5FxOjR5Mk[3N|k>
HEK293/pcDNA3.1 M1nvZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;oNGlEPTB;MT60OUDDuSByLkKwJI5O MUiyOFczPjd|OR?=
HEK293/ABCC1 M2fWUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2P4eWlEPTB;MUmuNlkhyrFiMj6wPEBvVQ>? NVX0bohCOjR5Mk[3N|k>
TCC M376VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3LnN|I1KGh? NVrUToZvUUN3ME23NEBvVQ>? MWmyOFcyPjl2NB?=
TCC M2DoR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjpUoQ1QCCq NHvmSVNKSzVyPUWwJI5O MVWyOFcyPjl2NB?=
HepG2/ADM MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGD5XHdKSzVyPUKuO|g3O8LzMD6yN|cyKM7:TR?= MmX5NlQ4ODR3NU[=
HepG2 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4PLO2lEPTB;MD6wNVE2yrFyLkCwNVch|ryP NX;R[JdoOjR5MES1OVY>
MCF-7/ADR NI\X[YRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkH1TWM2OD12LkS4NlbDuTBwMkC3NEDPxE1? NV;NepdlOjR5MES1OVY>
MCF-7 MlXkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml7DTWM2OD1yLkCxOVnDuTBwMEC2NkDPxE1? NGHtU20zPDdyNEW1Oi=>
A-172  MlexS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUWwMlHDqM7:TR?= NVv3bY5kOjRxN{KgbC=> NHraNFdqdmirYnn0d{Bk\WyuIHfyc5d1cCC2aX3lJIRmeGWwZHXueIx6 NX\2eGN7OjR3M{CyN|U>
U-251MG MofzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnrxNE4yyqEQvF2= M1\R[VI1Nzd{IHi= M3Lxd4lvcGmkaYTzJINmdGxiZ4Lve5RpKHSrbXWg[IVx\W6mZX70cJk> M{jZOFI1PTNyMkO1
DLD-1 NEfJVGpHfW6ldHnvckBCe3OjeR?= MUSxNFAhdk1? MnGzOFghcA>? NVLEPZR7eHKxbX;0[ZMhWlWQWEOg[IVu\XSqeXzheIlwdsLi M2XGblI1PDB|NEWz
CCD18Co M1PicGZ2dmO2aX;uJGF{e2G7 M1fZdVExOCCwTR?= NUHtRm1IPDhiaB?= NFLwTGZxem:vb4Tld{BTXU6[MzDk[Y1mfGi7bHH0bY9vyqB? MWqyOFQxOzR3Mx?=
DLD-1 MkPyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXewMVExODBibl2= NVXSepg{PDhiaB?= NY\zfZI{cW6qaXLpeJMh[2WubDDndo94fGhiZH;z[UBl\XCnbnTlcpRtgQ>? NHy0NZczPDRyM{S1Ny=>
CCD18Co NHzafphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3TTml1OC1zMECwJI5O NVzuNFlSPDhiaB?= NGPEcXpqdmirYnn0d{Bk\WyuIHfyc5d1cCCmb4PlJIRmeGWwZHXueIx6 NFX1NnUzPDRyM{S1Ny=>
HepG2 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1n1NVI1KGh? M1j5NmlEPTB;NUKuOgKBkc7:TR?= MVKyOFM1OTZ6OB?=
HEK293/pcDNA3.1 NFLnWJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWrXbodoUUN3ME2wMlAxPMLzMD6wNFA{KM7:TR?= MUCyOFI5PDd6Mx?=
HEK293/MRP1 M2rDcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF;neGxKSzVyPUCuNFU2yrFyLkCxNlAh|ryP MlPhNlQzQDR5OEO=
Ramos MoG1RZBweHSxc3nzJGF{e2G7 NYnOVlNZOuLCid88US=> Ml7MOFghcA>? MnXobY5lfWOnczCzOE43LcLzMT65NkUh[XCxcITvd4l{ NIi5WXUzPDJ3NkS5NS=>
NCI-H1299/pcDNA3 Ml\yR4VtdCCYaXHibYxqfHliQYPzZZk> NXS2UZlTOC1{MDDuUS=> M4D4W|k3KGh? MVrpcohq[mm2czDj[YxtKH[rYXLpcIl1gSCmb4PlJIRmeGWwZHXueIx6 MUmyOFE4PzBzMh?=
H1299/ICAM-3 NFnyZ|ZE\WyuIG\pZYJqdGm2eTDBd5NigQ>? NE\4NJcxNTJyIH7N NHP0ZoQ6PiCq MmXhbY5pcWKrdIOgZ4VtdCC4aXHibYxqfHliZH;z[UBl\XCnbnTlcpRtgQ>? NGXXTVUzPDF5N{CxNi=>
NCI-H1299/pcDNA3 M1ToT2Z2dmO2aX;uJGF{e2G7 NXrmN4ljOS93L{GwM|IxyqCwTR?= MXK5OkBp MoPVbY5lfWOnczDjcIVifmGpZTDv[kBk[XOyYYPld{0{NCB6LDC5MEBidmRiUFHSVC=> NVjDc5MzOjRzN{ewNVI>
H1299/ICAM-3 M3O5dWZ2dmO2aX;uJGF{e2G7 Mm\4NU82NzFyL{KwxsBvVQ>? NVjOb21MQTZiaB?= NHnQR4lqdmS3Y3XzJINt\WG4YXflJI9nKGOjc4Dhd4V{NTNuIEisJFktKGGwZDDQRXJR NEnDZ3czPDF5N{CxNi=>
W1 NHq3d3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH[ySnZKSzVyPUCuNFA{OiEQvF2= M2rSZ|I1OTRyMUe2
W1VR MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTBwMEW2JO69VQ>? NGTYflgzPDF2MEG3Oi=>
K562 NV33T4xFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTBwMEOyJOKyKDBwMECxJEDPxE1? NEm0NZQzPDF|NUmzOy=>
K562/ADR NUK1XVNiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXn5Upc2UUN3ME2zMlI3OSEEsTCwMlQyOiEQvF2= MUeyOFE{PTl|Nx?=
K562 NGm1N4pCeG:ydH;zbZMhSXO|YYm= NV;JSIk{OC5|IN88US=> MnvTNlQhcA>? MVLpcoR2[2W|IHHwc5B1d3OrczDzbYdvcW[rY3HueIx6 MXiyOFE{PTl|Nx?=
K562/ADR NWPkSmJYSXCxcITvd4l{KEG|c3H5 NF;BWng{KM7:TR?= M3y1OlI1KGh? M2\YT4lv\HWlZYOgZZBweHSxc3nz NITXUmozPDF|NUmzOy=>
A549 M2S2O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTBwMUCgxtEhOC5yMzFOwG0> MYSyN|k4OTB5NR?=
K562 NWLscIhqS2WubDDWbYFjcWyrdImgRZN{[Xl? MVizMlc26oDVNkFCpI5O M4\uUlczyqCqwrC= MVPpcohq[mm2czDj[YxtKH[rYXLpcIl1gSCmb4PlJIRmeGWwZHXueIx6 MUSyN|g4PzJ{Mx?=
lucena M1\DNWNmdGxiVnnhZoltcXS7IFHzd4F6 M1m2WFMvPzYkgKO2NOKhdk1? MlOzO|LDqGkEoB?= MVLuc{Bm\m[nY4S= NX\DVHFsOjN6N{eyNlM>
FEPS NEHGS4tE\WyuIG\pZYJqdGm2eTDBd5NigQ>? NW\XXYNbOy55NfMAl|YxyqCwTR?= NWCyTXgxPzMEoHlCpC=> NGLtZVJvdyCnZn\lZ5Q> NGn4blUzOzh5N{KyNy=>
A2780 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoTwTWM2OD1|LkWgcW0> MmG4NlM5Ojl{MEO=
ACHN MmjwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4DRcWlEPTB:MD6xJI1O MlzHNlM5Ojl{MEO=
U-937 M4PWcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoTKTWM2ODx|NDDuUS=> MVuyN|gzQTJyMx?=
Jurkat NHLrblBCeG:ydH;zbZMhSXO|YYm= MWm1xsDPxGdxbX|CpC=> MVOyOEBp M2HWeIlv\HWlZYOgZZBweHSxc3nzJJNq\26rZnnjZY51dHl? M1PmZ|I{QDFyNEC5
Jurkat MlvCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHXXb2Y2yqEQvHevcYzDqA>? NF\RVoMzPCCq Mlm0ZZJz\XO2IFr1dotifCClZXzsd{BqdiCJMj;NJJBp[XOn M3W0[FI{QDFyNEC5
Hep-2 M3zjeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGXINpVKSzVyPUCuNFTDuTBwMEGg{txO NV3HWGpOOjN5OEC0NlQ>
Hep-2/v NHn2NmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MorPTWM2OD1zLklCtVAvOjBizszN M3z3RVI{PzhyNEK0
SGC-7901 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4K4fVAuOTBizsznM41t NVnFd3ByOjRxNEivO|IhcA>? NIixXJVqdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDkc5NmKGGwZDD0bY1mKGSncHXu[IVvfCCvYX7u[ZI> MX[yN|c1OzV5Mh?=
SGC-7901/VCR NYezZ3NPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFS1[W0xNTFyIN88[{9udA>? M1P5Z|I1NzR6L{eyJIg> NHzRW3ZqdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDkc5NmKGGwZDD0bY1mKGSncHXu[IVvfCCvYX7u[ZI> MofPNlM4PDN3N{K=
SGC-7901 NI[xUWFCeG:ydH;zbZMhSXO|YYm= NGrLR4dqdmS3Y3XzJIFxd3C2b4Ppd{B{cWewaX\pZ4FvfGy7 MlfiNlM4PDN3N{K=
SGC-7901/VCR MoTtRZBweHSxc3nzJGF{e2G7 M2\XVolv\HWlZYOgZZBweHSxc3nzJJNq\26rZnnjZY51dHl? NGPSVYQzOzd2M{W3Ni=>
KB-3-1 NGn0Z29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;OTWM2OD1zLk[2JOKyKDBwMU[yJO69VQ>? MVKyN|Y4OzR2NR?=
KB-C2 M2jtdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTJyMj61OkDDuSB2Mj60PFEh|ryP M2XYSVI{Pjd|NES1
KB-3-1 Mn\zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVG3UYdjUUN3ME2xMlI3KMLzIECuNFI4KM7:TR?= M4fzcFI{Pjd|NES1
KB-V1 MlL5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M131UmlEPTB;MkC4Mlg2KMLzIEKwMlQh|ryP M3\LNVI{Pjd|NES1
HEK293/pcDNA3.1 NXP1bGVbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWjDT3VMUUN3ME2yOE4yKMLzIECuNlA1KM7:TR?= NVPLeYJHOjN4N{O0OFU>
HEK293/ABCB1 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmWzTWM2OD1|NUGyMlghyrFiM{e4MlM6OSEQvF2= NEOwXm4zOzZ5M{S0OS=>
A549/EGFP  MnvqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXuwMlAyNTFyMECg{txO NH;1e4ZKSzVyPUi2MlchyrFiMkmuNUDPxE1? NHT6PYEzOzZ|NEK4Ni=>
A549/Slug NWX1ZWVOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3LoS|AvODFvMUCwNEDPxE1? M3jEO2lEPTB;OT63JOKyKDNwMTFOwG0> MWSyN|Y{PDJ6Mh?=
JFCR39  Mn7tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{fpW|EhyrWP NY[1OWlYOjRiaB?= M1nJemROW09? NVPRWZlkdWG{a3XkcJkhcW6lcnXhd4V{KHSqZTDueY1j\XJib3[gS|IwVSCyaHHz[UBk\Wyucx?= NIP4N2MzOzV7OEK3Oi=>
A549 M2ftPWZ2dmO2aX;uJGF{e2G7 MVOxNFAhdk1? MUGxOkBp MXPEUXNQ MX3s[YFleyC2bzDhJIxwe3Nib3[gcYlkem:2dXL1cIV{ MWCyN|U6QDJ5Nh?=
SGC7901 NV7hNZNVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTFwMkdihKnDueLCiUCuNVEh|rypL33s NVjkeZJuOjN3NkS0PFI>
SGC7901/LV-NC M4Xadmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\rTWM2OD1zLke35qCKyrIkgJmwMlE3KM7:Zz;tcC=> NV3LVoI1OjN3NkS0PFI>
SGC7901/LV-SGO1 NXHDVlg6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFnLd4RKSzVyPUSuN|bjiIoEsfMAjVAvOzdizsznM41t M3fQR|I{PTZ2NEiy
SGC7901/VCR NILaVGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH;Oe|FKSzV|PUKwMlU{6oDLwsJihKkyNjl4IN88[{9udA>? MWSyN|U3PDR6Mh?=
SGC7901/VCR-NC NYrkO4YyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWS5V2xsUUN3ME2xPU45PuLCidMx5qCKOi5yMTFOwIcwdWx? MlPLNlM2PjR2OEK=
SGC7901/VCR-si-SGO1 M{fBfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MofYTWM2OD14LkG45qCKyrIkgJmxMlA{KM7:Zz;tcC=> M4rDSlI{PTZ2NEiy
SGC7901/ADR MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTdwOEZihKnDueLCiUCuOlQh|rypL33s M4ntUlI{PTZ2NEiy
SGC7901/ADR-NC MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVjo[2U1UUN3ME24Mlk{6oDLwsJihKkxNjZ6IN88[{9udA>? M1;5blI{PTZ2NEiy
SGC7901/ADR-si-SGO1 NEHKPGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEDYZ4NKSzVyPUOuOFbjiIoEsfMAjVAvOjlizsznM41t MUKyN|U3PDR6Mh?=
SH-SY5Y  NYjmOW53T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFPKdYwxNjByMT2xNEDPxE1? M2LCe|I1KGh? Mn7ETWM2OD1yLkGxN:KyOC5yMUKg{txO NYL0XmZJOjNzMkmwOlU>
SH-SY5Y  M3LYWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlWxNE4xODFvMUCg{txO MYK0PEBp NYDjXINxUUN3ME2wMlA4QMLzMD6wNFkh|ryP M4nEelI{OTJ7ME[1
SH-SY5Y  Mn30S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{nK[VAvODBzLUGwJO69VQ>? MnS1O|IhcA>? M1\wT2lEPTB;MD6wOVHDuTBwMEC4JO69VQ>? NV7JbopnOjNzMkmwOlU>
SH-SY5Y M3TZdGFxd3C2b4Ppd{BCe3OjeR?= MmP4NE4yKM7:TR?= M4DvSVAuOjRiaB?= MX7pcoR2[2W|IHHwc5B1d3OrczDv[kBUUC2VWUXZJINmdGy|IH\vcIxwf2mwZzDj[YxtKGO7Y3zlJIFzemW|dDDheEB1cGViR{KvUUBxcGG|ZR?= MnXCNlMyOjlyNkW=
SH-SY5Y MnW2RZBweHSxc3nzJGF{e2G7 NVHVbYxCOC5zIN88US=> MnrVNE0zPCCq NIDhc2xqdmS3Y3XzJI1qfG:2aXOgZZJz\XO2wrC= NEWzd3UzOzF{OUC2OS=>

... Click to View More Cell Line Experimental Data

In vivo Vincristine (3 mg/kg) administrated by a single i.p. injection to mice bearing bilateral subcutaneous xenografts Rh12 or Rh18, induces mean growth delay of >120 and >52 day, and repopulating fractions of 0.06% and 5%, respectively. [6] Vincristine acts on subcutaneous colon 38 tumors in mice by host cell-mediated vascular effects as well as by direct tubulin-mediated cytotoxicity. Vincristine (5 mg/kg) reduces tumor blood flow of tumors by nearly 75% . [7]

Protocol

Cell Research:[1]
+ Expand
  • Cell lines: B16 melanoma cell
  • Concentrations: 10 nM
  • Incubation Time: 3 days
  • Method: Cells are plated in 2 mL of medium in 35-mm plates at a concentration of about 5 × 104 cells/mL and grow for 24 h at 37 ℃ in an atmosphere of 5% CO2 and 95% air. Then medium is replaced with fresh medium lacking or containing 4 nM drug and proliferation is continued for 3 days. Cell counts are done each day in a Coulter Counter after detaching the cells with trypsin and EDTA.
    (Only for Reference)
Animal Research:[6]
+ Expand
  • Animal Models: Human rhabdomyosarcoma xenografts Rh12
  • Formulation: Water solutioin
  • Dosages: 3 mg/kg
  • Administration: A single i.p. administration
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (108.33 mM)
Water 60 mg/mL (65.0 mM)
Ethanol <1 mg/mL
In vivo Saline 30 mg/mL

* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 923.04
Formula

C46H58N4O14S

CAS No. 2068-78-2
Storage powder
in solvent
Synonyms Leurocristine

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03036904 Not yet recruiting Diffuse Large B-Cell Lymphoma|High Grade B-Cell Lymphoma Weill Medical College of Cornell University|Genentech, Inc.|Massachusetts General Hospital|M.D. Anderson Cancer Center February 6, 2017 Phase 1
NCT03007147 Not yet recruiting B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1|BCR-ABL1 Fusion Protein Expression|Minimal Residual Disease|Philadelphia Chromosome Positive|T Acute Lymphoblastic Leukemia|Untreated Adult Acute Lymphoblastic Leukemia|Untreated Childhood Acute Lymphoblastic Leukemia Childrens Oncology Group|National Cancer Institute (NCI) July 2017 Phase 3
NCT03023358 Not yet recruiting Peripheral T Cell Lymphoma Nanfang Hospital of Southern Medical University February 2017 Phase 3
NCT03023046 Not yet recruiting Adult Acute Lymphoblastic Leukemia|Adult Lymphoblastic Lymphoma|CD20 Positive|Philadelphia Chromosome Positive University of Washington|National Cancer Institute (NCI) February 2017 Phase 2
NCT03003520 Recruiting Lymphoma, Large B-Cell, Diffuse Celgene February 2017 Phase 2
NCT03018626 Not yet recruiting Lymphoma, Large B-Cell, Diffuse Nanfang Hospital of Southern Medical University February 2017 Phase 3

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Microtubule Associated Signaling Pathway Map

Related Microtubule Associated Products

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID