Vinblastine sulfate

Catalog No.S4505 Synonyms: NSC49842

Vinblastine sulfate Chemical Structure

Molecular Weight(MW): 909.05

Vinblastine sulfate inhibits microtubule formation and suppresses nAChR activity with IC50 of 8.9 μM in a cell-free assay, used to treat certain kinds of cancer.

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Biological Activity

Description Vinblastine sulfate inhibits microtubule formation and suppresses nAChR activity with IC50 of 8.9 μM in a cell-free assay, used to treat certain kinds of cancer.
Targets
nAChR [1]
(Adrenal Chromaffin Cells)
8.9 μM
In vitro

The average terminal half-lives of Vinblastine is 14.3 h. When incubated in freshly isolated rat hepatocytes, VLB penetrates rapidly and intensely into the cells, probably through a passive diffusion mechanism followed by tight cellular binding[3]. Vinblastine inhibits the angiogenic response induced by adrenomedullin and is also positive for mitotic slippage, causing micronuclei in mononucleate cells with cytokinesis block[4]. vinblastine gives significant increase in micronucleated mononucleated cells at concentrations that produced approximately 50% cell death and cytostasis or less as calculated using RPD, RICC and RCC[2].

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
COLO 320 human colorectal carcinoma cell line NFHROJFHfW6ldHnvckBie3OjeR?= NIm4TVJKdiC4aYTyc{Bkd26lZX70doF1cW:wIILldZVqemWmIITvJItqdGxiNUClJI9nKEORTF:gN|IxKGi3bXHuJINwdG:{ZXP0ZYwh[2G{Y3nuc41iKGOnbHygcIlv\SxiRVO1NF0xNjB6IN88US=> NIn4fXMyOjN4MUO5Oy=>
LNCaP human prostate cancer cell line MnjQSpVv[3Srb36gZZN{[Xl? NV22PWI{UW5idnn0do8h[2:wY3XueJJifGmxbjDy[ZF2cXKnZDD0c{BscWyuIEWwKUBw\iCOTlPhVEBpfW2jbjDwdo9{fGG2ZTDjZY5k\XJiY3XscEBtcW6nLDDFR|UxRTBwNTFOwG0> M3nqeFEzOzZzM{m3
K562 cell NVi1OVZJT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M33nUGlvKH[rdILvJIlvcGmkaYTvdpkh[2:wY3XueJJifGmxbjDh[4FqdnO2IHj1cYFvKGOqcn;ubYMhdXmnbH;n[Y5wfXNibHX1b4VucWFiS{W2NkBk\WyuIHfyc5d1cCxiSVO1NF0xNjByMTFOwG0> MXOxNlg2Ojd4OB?=
T47D cells M{\4U2Z2dmO2aX;uJIF{e2G7 NIm3[VBKdiC4aYTyc{Bkd26lZX70doF1cW:wIILldZVqemWmIITvJItqdGxiNUClJI9nKFR2N1SgbJVu[W5iYoLlZZN1KGS3Y4ThcEBk[XKlaX7vcYEh[2WubDDsbY5mNCCHQ{WwQVAvODhizszN NYrhXoM6OTJ|NkGzPVc>
K562 cell NGXmbYRRem:uaX\ldoF1cW:wIHHzd4F6 M1u0ZVQ5KGh? MXrBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEt3NkKgZ4VtdHNiYX\0[ZIhPDhiaILzMEBKSzVyPUCuNFAyKM7:TR?= NUHWWYVXOTl{MkCwNVg>
ACHN cells NFjYeWFEgXSxdH;4bYNqfHliYYPzZZk> M4DoWVQ5KGh? NFPQdpNEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCS0iQIHPlcIx{KGGodHXyJFQ5KGi{czDifUBUWkJiYYPzZZktKEmFNUC9NlIvPyEQvF2= NWjUTlNCOTl2Nke4O|c>
A375 cells M4[0SmN6fG:2b4jpZ4l1gSCjc4PhfS=> NVu2NFBpPDhiaB?= MlfTR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVM4PSClZXzsd{Bi\nSncjC0PEBpenNiYomgV3JDKGG|c3H5MEBKSzVyPUeuNkDPxE1? NXLF[XN[OTl2Nke4O|c>
C32 cells MWHDfZRwfG:6aXPpeJkh[XO|YYm= NWj4Rm9jPDhiaB?= Mnr5R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gR|MzKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDTVmIh[XO|YYmsJGlEPTB;MzFOwG0> M3m1SlE6PDZ5OEe3
LNCAP cells Mk\YR5l1d3SxeHnjbZR6KGG|c3H5 MnvCOFghcA>? NGfx[FhEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBNVkODUDDj[YxteyCjZoTldkA1QCCqcoOgZpkhW1KEIHHzd4F6NCCLQ{WwQVI6NjNizszN MmPkNVk1Pjd6N{e=
Huh-7D12 cells NV;oVnM1S3m2b4TvfIlkcXS7IHHzd4F6 MnXQOFghcA>? NF7LNItEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJfWhvN1SxNkBk\WyuczDh[pRmeiB2ODDodpMh[nliU2LCJIF{e2G7LDDJR|UxRTR3Lk[g{txO MYCxPVQ3Pzh5Nx?=
COR-L23 cells MXTDfZRwfG:6aXPpeJkh[XO|YYm= M3u3PVQ5KGh? MVLDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDDU3IuVDJ|IHPlcIx{KGGodHXyJFQ5KGi{czDifUBUWkJiYYPzZZktKEmFNUC9OFUvPSEQvF2= NVHTXWtnOTl2Nke4O|c>
142BR cells MmX2R5l1d3SxeHnjbZR6KGG|c3H5 M1z2TVQ5KGh? MU\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjCxOFJDWiClZXzsd{Bi\nSncjC0PEBpenNiYomgV3JDKGG|c3H5MEBKSzVyPUO3MlYh|ryP NXPWXXVpOTl2Nke4O|c>
HT-29 cells M{DiOGN6fG:2b4jpZ4l1gSCjc4PhfS=> M4Swd|Q5KGh? M4Lmc2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhVNTJ7IHPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFNiYYPzZZktKEmFNUC9NE42PSEQvF2= MX:yNVkzODd4Mh?=
A549 cells M13IR3Bzd2yrZnXyZZRqd25iYYPzZZk> NETWdHk1QCCq NWrHeJl1SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHMh[XO|YYmsJGlEPTB;Mj6zOkDPxE1? M3zGXlIzPTR4Nke0
DU145 cells MnXpVJJwdGmoZYLheIlwdiCjc4PhfS=> Mlz6OFghcA>? NG\QfphCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFTVNVQ2KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHMh[XO|YYmsJGlEPTB;ND6yOUDPxE1? NXjQVmpGOjJ3NE[2O|Q>
SK-MEL-5 cells M1TiUnBzd2yrZnXyZZRqd25iYYPzZZk> NHG3fVU1QCCq NXnOOnd5SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDTT{1OTUxvNTDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSVIHHzd4F6NCCLQ{WwQVEvPzRizszN MWGyNlU1PjZ5NB?=
HepG2 cells MlnqVJJwdGmoZYLheIlwdiCjc4PhfS=> MoH5OFghcA>? NETTS4FCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjldGczKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHMh[XO|YYmsJGlEPTB;MD6xOkDPxE1? M3jQUVIzPTR4Nke0
HT-29 cells M1TSSXBzd2yrZnXyZZRqd25iYYPzZZk> MUe0PEBp NHTCSGtCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjUMVI6KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHMh[XO|YYmsJGlEPTB;MUGuNVgh|ryP M2HHb|IzPTR4Nke0
MCF7 cells MoPPVJJwdGmoZYLheIlwdiCjc4PhfS=> NH\ScGo1QCCq Mn\0RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPQ1[3JINmdGy|IHHmeIVzKDR6IHjyd{BjgSCPVGOgZZN{[XluIFnDOVA:OjRwMEig{txO MkPNNlI2PDZ4N{S=
MDA-MB-231 cells NHHNVlZRem:uaX\ldoF1cW:wIHHzd4F6 NILQV5M1QCCq NX;aZ5ZXSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvMkOxJINmdGy|IHHmeIVzKDR6IHjyd{BjgSCPVGOgZZN{[XluIFnDOVA:OzFwNUKg{txO NITJeIEzOjV2Nk[3OC=>
rat REF52 cells MorqSpVv[3Srb36gZZN{[Xl? MYGwMlEh|ryP MW[zNEBucW6| NF7mUFlKdmS3Y4Tpc44hd2ZibXnjdo91fWK3bHWg[IVxd2y7bXXybZpifGmxbjDpckBz[XRiUlXGOVIh[2WubIOgZZQhOC5zIIXNJIFnfGW{IEOwJI1qdnNiYomg[ox2d3Knc3PlcoNmKGG|c3H5 MYGyN|k1Pzh{Nh?=
HepG2 cells NYLTN4VjS3m2b4TvfIlkcXS7IHHzd4F6 MXG3NkBp MlXJR5l1d3SxeHnjbZR6KGGpYXnud5Qh[WS{aXHtfYNqdi2{ZYPpd5RidnRiaIXtZY4hUGWyR{KgZ4VtdHNiYYPz[ZN{\WRiYYOg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OD1yLkC1OkDPxE1? M4OydlI{PzB6MEGw
HepG2 cells M3q2VWN6fG:2b4jpZ4l1gSCjc4PhfS=> M3nwRlczKGh? MX3DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwQVAvODF7IN88US=> NXW5[mpQOjN5MEiwNVA>
K562 cells M1LPW2N6fG:2b4jpZ4l1gSCjc4PhfS=> NHLvcZI4OiCq NH3ve|JEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBMPTZ{IHPlcIx{KGG|c3Xzd4VlKGG|IHfyc5d1cCCrbnjpZol1cW:wIHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVA:OC5yMU[g{txO NEmwSVAzOzdyOECxNC=>
MDA-MB-231 cells M2rj[GN6fG:2b4jpZ4l1gSCjc4PhfS=> Ml\QO|IhcA>? NVPrbVBCS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUSDLV3CMVI{OSClZXzsd{Bie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwQVAvODB6MzFOwG0> M1jmUlI{PzB6MEGw
MCF7 cells NVL3S2ZzS3m2b4TvfIlkcXS7IHHzd4F6 MYK3NkBp M3HhRmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1ETjdiY3XscJMh[XO|ZYPz[YQh[XNiZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NF0xNjByNzFOwG0> M{jpPVI{PzB6MEGw
SCL6 cells MXLDfZRwfG:6aXPpeJkh[XO|YYm= NIjndVBEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBUS0x4IHPlcIx{KGK7IF3UWEBie3OjeTygSWQ2OD14LkGg{rxu M333PFEzQDhyM{G0
SCL9 M4PGPGN6fG:2b4jpZ4l1gSCjc4PhfS=> MUXDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDTR2w6KGOnbHzzJIJ6KE2WVDDhd5NigSxiRVS9OU4{KM7:TR?= MXmxNlg5ODNzNB?=
KATO III cells NXy0dGJJS3m2b4TvfIlkcXS7IHHzd4F6 MnHHR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gT2FVVyCLSVmgZ4VtdHNiYomgUXRVKGG|c3H5MEBGTDVyPU[uNUDPxE1? MnuwNVI5QDB|MUS=
NUGC4 cells M4DyWGN6fG:2b4jpZ4l1gSCjc4PhfS=> MnzOR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUnVISzRiY3XscJMh[nliTWTUJIF{e2G7LDDFSFUxRTVwMzFOwG0> MW[xNlg5ODNzNB?=
UACC903 cells MljYR5l1d3SxeHnjbZR6KGG|c3H5 MVK0PEBp M2rjdWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHVCS0N7MEOgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WUzDhd5NigSxiSVO1NF0yNjZ3IN88US=> NVfrb|J[OjF7MkC3OlI>
K562 cells M{TRPWZ2dmO2aX;uJIF{e2G7 MU\Jcohq[mm2aX;uJI9nKHS3YoXsbY4heG:ueX3ldol7[XSrb36gbY4hcHWvYX6gT|U3OiClZXzsd{whUUN3ME2wMlE{KM7:TR?= MlLLNlA2PDZ7OEC=
BxPC3 cells NG\QV3pRem:uaX\ldoF1cW:wIHHzd4F6 MXu0PEBp Ml\XRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCEeGDDN{Bk\WyuczDh[pRmeiB2ODDodpMh[nliTWTTJIF{e2G7LDDJR|UxRTFwMUOg{txO MmLPNlI2PDZ4N{S=

... Click to View More Cell Line Experimental Data

In vivo Vinblastine is a widely used anticancer drug with undesired side effects [6]. A combination of VBL and RAP at very low doses against human HCC gets a satisfactory antiangiogenic effect in vivo[4]. The clinically relevant dose of vinblastine inhibits palmitoylation of tubulin in vivo in CEM cells (effect on depalmitoylation of tubulin)[5].

Protocol

Cell Research:

[2]

+ Expand
  • Cell lines: Chinese hamster ovary (CHO) cells
  • Concentrations: 1% (v/v) (dissolved in DMSO)
  • Incubation Time: 3h
  • Method:

    Six-well treatment plates are set up that contained 5 × 104 cells/mL in each well, suspended in 3 mL culture medium, and these are treated with vinblastine for 3 h followed by 21 h growth.


    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (110.0 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 909.05
Formula

C46H58N4O9.H2SO4

CAS No. 143-67-9
Storage powder
Synonyms NSC49842

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID