Vinblastine sulfate

Catalog No.S4505 Synonyms: NSC49842

Vinblastine sulfate Chemical Structure

Molecular Weight(MW): 909.05

Vinblastine sulfate inhibits microtubule formation and suppresses nAChR activity with IC50 of 8.9 μM in a cell-free assay, used to treat certain kinds of cancer.

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Biological Activity

Description Vinblastine sulfate inhibits microtubule formation and suppresses nAChR activity with IC50 of 8.9 μM in a cell-free assay, used to treat certain kinds of cancer.
Targets
nAChR [1]
(Adrenal Chromaffin Cells)
8.9 μM
In vitro

The average terminal half-lives of Vinblastine is 14.3 h. When incubated in freshly isolated rat hepatocytes, VLB penetrates rapidly and intensely into the cells, probably through a passive diffusion mechanism followed by tight cellular binding[3]. Vinblastine inhibits the angiogenic response induced by adrenomedullin and is also positive for mitotic slippage, causing micronuclei in mononucleate cells with cytokinesis block[4]. vinblastine gives significant increase in micronucleated mononucleated cells at concentrations that produced approximately 50% cell death and cytostasis or less as calculated using RPD, RICC and RCC[2].

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
COLO 320 human colorectal carcinoma cell line M{LLemZ2dmO2aX;uJIF{e2G7 M{W3PWlvKH[rdILvJINwdmOnboTyZZRqd25icnXxeYlz\WRidH:gb4ltdCB3MDWgc4YhS0:OTzCzNlAhcHWvYX6gZ49td3KnY4ThcEBk[XKlaX7vcYEh[2WubDDsbY5mNCCHQ{WwQVAvODhizszN MYmxNlM3OTN7Nx?=
LNCaP human prostate cancer cell line Mmf3SpVv[3Srb36gZZN{[Xl? M2rBXGlvKH[rdILvJINwdmOnboTyZZRqd25icnXxeYlz\WRidH:gb4ltdCB3MDWgc4YhVE6FYWCgbJVu[W5icILvd5RifGViY3HuZ4VzKGOnbHygcIlv\SxiRVO1NF0xNjVizszN MV:xNlM3OTN7Nx?=
K562 cell M{T6fWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NWjRbVl{UW5idnn0do8hcW6qaXLpeI9zgSClb37j[Y51emG2aX;uJIFo[Wmwc4SgbJVu[W5iY3jyc45q[yCveXXsc4dmdm:3czDs[ZVs\W2rYTDLOVYzKGOnbHyg[5Jwf3SqLDDJR|UxRTBwMECxJO69VQ>? M1;JcFEzQDV{N{[4
T47D cells NEPpPVRHfW6ldHnvckBie3OjeR?= MUjJckB3cXS{bzDjc45k\W62cnH0bY9vKHKncYXpdoVlKHSxIHvpcIwhPTBnIH;mJHQ1P0RiaIXtZY4h[nKnYYP0JIR2[3SjbDDjZZJkcW6xbXGgZ4VtdCCuaX7lMEBGSzVyPUCuNFgh|ryP MUSxNlM3OTN7Nx?=
K562 cell M1q5WXBzd2yrZnXyZZRqd25iYYPzZZk> NEHN[lQ1QCCq M1zGcGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iS{W2NkBk\WyuczDh[pRmeiB2ODDodpMtKEmFNUC9NE4xODFizszN M1\0OVE6OjJyMEG4
ACHN cells M1fSXGN6fG:2b4jpZ4l1gSCjc4PhfS=> Mm\zOFghcA>? NV;BSVU{S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSUOKTjDj[YxteyCjZoTldkA1QCCqcoOgZpkhW1KEIHHzd4F6NCCLQ{WwQVIzNjdizszN NWnHU4NnOTl2Nke4O|c>
A375 cells NXjabZAzS3m2b4TvfIlkcXS7IHHzd4F6 M3z2S|Q5KGh? NVrZfFA3S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTN5NTDj[YxteyCjZoTldkA1QCCqcoOgZpkhW1KEIHHzd4F6NCCLQ{WwQVcvOiEQvF2= NHjEe2gyQTR4N{i3Oy=>
C32 cells NX3aUJJLS3m2b4TvfIlkcXS7IHHzd4F6 MYO0PEBp MWjDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDDN|Ih[2WubIOgZYZ1\XJiNEigbJJ{KGK7IGPSRkBie3OjeTygTWM2OD1|IN88US=> M3LjblE6PDZ5OEe3
LNCAP cells M4mwV2N6fG:2b4jpZ4l1gSCjc4PhfS=> MYm0PEBp NI[0T3dEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBNVkODUDDj[YxteyCjZoTldkA1QCCqcoOgZpkhW1KEIHHzd4F6NCCLQ{WwQVI6NjNizszN NYfIemQ2OTl2Nke4O|c>
Huh-7D12 cells NX\SdWs3S3m2b4TvfIlkcXS7IHHzd4F6 MUG0PEBp Mof4R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTJVpNTeGMUKgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KFOUQjDhd5NigSxiSVO1NF01PS54IN88US=> NEDZZpMyQTR4N{i3Oy=>
COR-L23 cells NXu2ZmdJS3m2b4TvfIlkcXS7IHHzd4F6 MoLjOFghcA>? NYTlSXNVS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hS0:ULVyyN{Bk\WyuczDh[pRmeiB2ODDodpMh[nliU2LCJIF{e2G7LDDJR|UxRTR3LkWg{txO NIj0dmgyQTR4N{i3Oy=>
142BR cells NVTFeoxqS3m2b4TvfIlkcXS7IHHzd4F6 M4Dx[FQ5KGh? MXrDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjCxOFJDWiClZXzsd{Bi\nSncjC0PEBpenNiYomgV3JDKGG|c3H5MEBKSzVyPUO3MlYh|ryP NEi0[mwyQTR4N{i3Oy=>
HT-29 cells M4fVb2N6fG:2b4jpZ4l1gSCjc4PhfS=> M3vSUFQ5KGh? MmTZR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTHQuOjliY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VWyCjc4PhfUwhUUN3ME2wMlU2KM7:TR?= NH;5bZkzOTl{MEe2Ni=>
A549 cells NWjh[5V1WHKxbHnm[ZJifGmxbjDhd5NigQ>? MkXYOFghcA>? M2ftR2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQUW0PUBk\WyuczDh[pRmeiB2ODDodpMh[nliTWTTJIF{e2G7LDDJR|UxRTJwM{[g{txO MX[yNlU1PjZ5NB?=
DU145 cells MnHoVJJwdGmoZYLheIlwdiCjc4PhfS=> NHPXRm41QCCq MYLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKESXMUS1JINmdGy|IHHmeIVzKDR6IHjyd{BjgSCPVGOgZZN{[XluIFnDOVA:PC5{NTFOwG0> NV7xOZNbOjJ3NE[2O|Q>
SK-MEL-5 cells M2jyVnBzd2yrZnXyZZRqd25iYYPzZZk> MmrLOFghcA>? MVzBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFONLV3FUE02KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHMh[XO|YYmsJGlEPTB;MT63OEDPxE1? M{L2XFIzPTR4Nke0
HepG2 cells NXLlfYFlWHKxbHnm[ZJifGmxbjDhd5NigQ>? M{HROFQ5KGh? MlfPRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKZYDHNkBk\WyuczDh[pRmeiB2ODDodpMh[nliTWTTJIF{e2G7LDDJR|UxRTBwMU[g{txO MmnGNlI2PDZ4N{S=
HT-29 cells MXzQdo9tcW[ncnH0bY9vKGG|c3H5 MVi0PEBp M4PuUmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSGStNlkh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UV{Bie3OjeTygTWM2OD1zMT6xPEDPxE1? NVnMOZd4OjJ3NE[2O|Q>
MCF7 cells NVTiV|BEWHKxbHnm[ZJifGmxbjDhd5NigQ>? NYTpd|lUPDhiaB?= NEDlPFBCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3DSlch[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UV{Bie3OjeTygTWM2OD1{ND6wPEDPxE1? NV3QWXp1OjJ3NE[2O|Q>
MDA-MB-231 cells NViyR|g1WHKxbHnm[ZJifGmxbjDhd5NigQ>? NUG2XmN1PDhiaB?= NGXzR3ZCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3ERU1OSi1{M{GgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WUzDhd5NigSxiSVO1NF0{OS53MjFOwG0> NEjKV3AzOjV2Nk[3OC=>
rat REF52 cells MW\GeY5kfGmxbjDhd5NigQ>? NHLvO2QxNjFizszN MVSzNEBucW6| NFHJblVKdmS3Y4Tpc44hd2ZibXnjdo91fWK3bHWg[IVxd2y7bXXybZpifGmxbjDpckBz[XRiUlXGOVIh[2WubIOgZZQhOC5zIIXNJIFnfGW{IEOwJI1qdnNiYomg[ox2d3Knc3PlcoNmKGG|c3H5 NVS4bVNVOjN7NEe4NlY>
HepG2 cells MmnFR5l1d3SxeHnjbZR6KGG|c3H5 MWC3NkBp NYX6R412S3m2b4TvfIlkcXS7IHHnZYlve3RiYXTybYFugWOrbj3y[ZNqe3SjboSgbJVu[W5iSHXwS|Ih[2WubIOgZZN{\XO|ZXSgZZMh\3Kxd4ToJIlvcGmkaYTpc44h[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3ME2wMlA2PiEQvF2= MU[yN|cxQDBzMB?=
HepG2 cells MX3DfZRwfG:6aXPpeJkh[XO|YYm= Mo\mO|IhcA>? NVe2OmVvS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyR{KgZ4VtdHNiYYPz[ZN{\WRiYYOg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OD1yLkCxPUDPxE1? NEfKbIszOzdyOECxNC=>
K562 cells MoDIR5l1d3SxeHnjbZR6KGG|c3H5 NGrrRXU4OiCq MYnDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzJIF{e2W|c3XkJIF{KGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUC9NE4xOTZizszN NV;lNmo2OjN5MEiwNVA>
MDA-MB-231 cells NE\zWXREgXSxdH;4bYNqfHliYYPzZZk> M1TxPVczKGh? MoTMR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWRCNU2ELUKzNUBk\WyuczDhd5Nme3OnZDDhd{Boem:5dHigbY5pcWKrdHnvckBi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyPUCuNFA5OyEQvF2= NUDS[o1SOjN5MEiwNVA>
MCF7 cells NIDOUHdEgXSxdH;4bYNqfHliYYPzZZk> NIrmco44OiCq MoPER5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWNHPyClZXzsd{Bie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwQVAvODB5IN88US=> M3vyfVI{PzB6MEGw
SCL6 cells M1XYbWN6fG:2b4jpZ4l1gSCjc4PhfS=> M4jjcmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHNEVDZiY3XscJMh[nliTWTUJIF{e2G7LDDFSFUxRTZwMTFOoI0> Mn3BNVI5QDB|MUS=
SCL9 MXnDfZRwfG:6aXPpeJkh[XO|YYm= MYHDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDTR2w6KGOnbHzzJIJ6KE2WVDDhd5NigSxiRVS9OU4{KM7:TR?= NX[1eY9POTJ6OECzNVQ>
KATO III cells NYLTVIJMS3m2b4TvfIlkcXS7IHHzd4F6 MYnDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDLRXRQKEmLSTDj[YxteyCkeTDNWHQh[XO|YYmsJGVFPTB;Nj6xJO69VQ>? NW[zS4s{OTJ6OECzNVQ>
NUGC4 cells NHGy[|ZEgXSxdH;4bYNqfHliYYPzZZk> MnzPR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUnVISzRiY3XscJMh[nliTWTUJIF{e2G7LDDFSFUxRTVwMzFOwG0> MWixNlg5ODNzNB?=
UACC903 cells MXvDfZRwfG:6aXPpeJkh[XO|YYm= NXLiTXA5PDhiaB?= NWXvUVRvS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hXUGFQ{mwN{Bk\WyuczDh[pRmeiB2ODDodpMh[nliTWTTJIF{e2G7LDDJR|UxRTFwNkWg{txO NHXTTJUzOTl{MEe2Ni=>
K562 cells MX\GeY5kfGmxbjDhd5NigQ>? NYn1UWFJUW6qaXLpeIlwdiCxZjD0eYJ2dGmwIIDvcJlu\XKrenH0bY9vKGmwIHj1cYFvKEt3NkKgZ4VtdHNuIFnDOVA:OC5zMzFOwG0> M2GwblIxPTR4OUiw
BxPC3 cells NEXHcZJRem:uaX\ldoF1cW:wIHHzd4F6 NF;jcoo1QCCq NGH0OmRCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFL4VGM{KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHMh[XO|YYmsJGlEPTB;MT6xN{DPxE1? MkTyNlI2PDZ4N{S=

... Click to View More Cell Line Experimental Data

In vivo Vinblastine is a widely used anticancer drug with undesired side effects [6]. A combination of VBL and RAP at very low doses against human HCC gets a satisfactory antiangiogenic effect in vivo[4]. The clinically relevant dose of vinblastine inhibits palmitoylation of tubulin in vivo in CEM cells (effect on depalmitoylation of tubulin)[5].

Protocol

Cell Research:

[2]

+ Expand
  • Cell lines: Chinese hamster ovary (CHO) cells
  • Concentrations: 1% (v/v) (dissolved in DMSO)
  • Incubation Time: 3h
  • Method:

    Six-well treatment plates are set up that contained 5 × 104 cells/mL in each well, suspended in 3 mL culture medium, and these are treated with vinblastine for 3 h followed by 21 h growth.


    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (110.0 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 909.05
Formula

C46H58N4O9.H2SO4

CAS No. 143-67-9
Storage powder
in solvent
Synonyms NSC49842

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID