Catalog No.S4505 Synonyms: NSC49842
Molecular Weight(MW): 909.05
Vinblastine sulfate inhibits microtubule formation and suppresses nAChR activity with IC50 of 8.9 μM in a cell-free assay, used to treat certain kinds of cancer.
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Choose Selective Microtubule Associated Inhibitors
|Description||Vinblastine sulfate inhibits microtubule formation and suppresses nAChR activity with IC50 of 8.9 μM in a cell-free assay, used to treat certain kinds of cancer.|
The average terminal half-lives of Vinblastine is 14.3 h. When incubated in freshly isolated rat hepatocytes, VLB penetrates rapidly and intensely into the cells, probably through a passive diffusion mechanism followed by tight cellular binding. Vinblastine inhibits the angiogenic response induced by adrenomedullin and is also positive for mitotic slippage, causing micronuclei in mononucleate cells with cytokinesis block. vinblastine gives significant increase in micronucleated mononucleated cells at concentrations that produced approximately 50% cell death and cytostasis or less as calculated using RPD, RICC and RCC.
|In vivo||Vinblastine is a widely used anticancer drug with undesired side effects . A combination of VBL and RAP at very low doses against human HCC gets a satisfactory antiangiogenic effect in vivo. The clinically relevant dose of vinblastine inhibits palmitoylation of tubulin in vivo in CEM cells (effect on depalmitoylation of tubulin).|
-  McKay DB, et al. Proc Soc Exp Biol Med. 1993, 203(3):372-376.
-  George E. Johnson, et al. Mutat Res. 2010, 702(2):189-192.
-  Zhou XJ, et al. Eur J Drug Metab Pharmacokinet. 1990, 15(4):323-332.
|In vitro||DMSO||100 mg/mL (110.0 mM)|
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