Albendazole

Catalog No.S1640 Synonyms: SKF-62979

Albendazole Chemical Structure

Molecular Weight(MW): 265.33

Albendazole is a member of the benzimidazole compounds used as a drug indicated for the treatment of a variety of worm infestations.

Size Price Stock Quantity  
In DMSO USD 130 In stock
USD 97 In stock

Free Overnight Delivery on orders over $ 500
Next day delivery by 10:00 a.m. Order now.

Purity & Quality Control

Choose Selective Microtubule Associated Inhibitors

Click to view more

Notes:

2. For more details, such as half maximal inhibitory concentrations (IC50s) and working concentrations of each inhibitor, please click on the link of the inhibitor of interest.
3. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
4. Orange "√" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

Biological Activity

Description Albendazole is a member of the benzimidazole compounds used as a drug indicated for the treatment of a variety of worm infestations.
Targets
tubulin [1]
In vitro

Albendazole is reported to be teratogenic in rats, and is extensively metabolized to the sulfoxide derivative. Albendazole and its sulfoxide metabolite elicit an accumulation of cells in the mitotic phase of the cell cycle. [1]

In vivo Albendazole causes an induction of hepatic activities of CYP1A1-associated ethoxyresorufin O-deethylase (EROD) 65 fold, CYP1A2-associated methoxyresorufin O-demethylase (MROD) 6 fold, CYP2B1-associated penthoxyresorufin O-dealkylase (PROD) 4 fold, CYP2B2-associated benzyloxyresorufin O-dealkylase (BROD) 14 fold, as well as a partial reduction of CYP2E1-associated 4-nitrophenol hydroxylase (4-NPH) activity in the rat. [2] Albendazole is metabolized to its pharmacologically active sulfoxide metabolites by liver and lung microsomes from sheep and cattle, as well as by cattle intestinal microsomes. [3] Albendazole (ABZ) is a benzimidazole derivative with a broad spectrum of activity against human and animal helminthe parasites. [4] Albendazole and its metabolites are extensively distributed to the digestive tract, mainly into the abomasal fluid, after the i.v. and i.r. administrations. Albendazole and its active albendazole sulphoxide (ABZSO) metabolite are recovered in tapeworms collected from both i.v. and i.r. treated lambs. [5]

Protocol

Solubility (25°C)

In vitro DMSO 17 mg/mL (64.07 mM)
Water <1 mg/mL
Ethanol <1 mg/mL
In vivo

* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 265.33
Formula

C12H15N3O2S

CAS No. 54965-21-8
Storage powder
in solvent
Synonyms SKF-62979

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00375583 Completed Lymphatic Filariasis|Wuchereria Bancrofti Infection National Institute of Allergy and Infectious Diseases (NIAID)|Tuberculosis Research Centre, India|National Institutes of Health Clinical Center (CC) September 9, 2006 Phase 2
NCT00339417 Completed Lymphatic Filariasis National Institute of Allergy and Infectious Diseases (NIAID)|National Institutes of Health Clinical Center (CC) February 22, 2006 Phase 2
NCT03014167 Not yet recruiting Helminthiasis|Filariasis Natural History Museum, United Kingdom|Bill and Melinda Gates Foundation|University of Washington|Imperial College London|London School of Hygiene and Tropical Medicine|Institut de Recherche Clinique du Bénin (IRCB)|Institut de Recherche pour le Developpement|Christian Medical College, Vellore, India|Blantyre Institute for Community Ophthalmology (BICO)|Swiss Tropical & Public Health Institute March 2017 Phase 4
NCT03036059 Not yet recruiting Lymphatic Filariasis|Helminth Infection Noguchi Memorial Institute for Medical Research|Ghana Health Services March 2017 Phase 4
NCT02636803 Not yet recruiting Helminthiasis Robert Gilman|Universidad Peruana Cayetano Heredia|Johns Hopkins Bloomberg School of Public Health February 2017 Phase 2
NCT03032042 Not yet recruiting Helminth Infection Francis I. Proctor Foundation January 2017 Phase 4

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Microtubule Associated Signaling Pathway Map

Related Microtubule Associated Products

Tags: buy Albendazole | Albendazole ic50 | Albendazole price | Albendazole cost | Albendazole solubility dmso | Albendazole purchase | Albendazole manufacturer | Albendazole research buy | Albendazole order | Albendazole mouse | Albendazole chemical structure | Albendazole mw | Albendazole molecular weight | Albendazole datasheet | Albendazole supplier | Albendazole in vitro | Albendazole cell line | Albendazole concentration | Albendazole nmr
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID