Albendazole

Catalog No.S1640

Albendazole is a member of the benzimidazole compounds used as a drug indicated for the treatment of a variety of worm infestations.

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Albendazole Chemical Structure

Albendazole Chemical Structure
Molecular Weight: 265.33

Validation & Quality Control

Quality Control & MSDS

Related Compound Libraries

Albendazole is available in the following compound libraries:

Product Information

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Product Description

Biological Activity

Albendazole(Albenza) is a member of the benzimidazole compounds used as a drug indicated for the treatment of a variety of worm infestations. Albendazole causes degenerative alterations in the tegument and intestinal cells of the worm by binding to the colchicine-sensitive site of tubulin, thus inhibiting its polymerization or assembly into microtubules. The loss of the cytoplasmic microtubules leads to impaired uptake of glucose by the larval and adult stages of the susceptible parasites, and depletes their glycogen stores. [1]

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesBaboonDogMonkeyRabbitGuinea pigRatHamsterMouse
Weight (kg)121031.80.40.150.080.02
Body Surface Area (m2)0.60.50.240.150.050.0250.020.007
Km factor202012128653
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)

Clinical Trial Information( data from http://clinicaltrials.gov, updated on 2014-09-20)

NCT Number Recruitment Conditions Sponsor
/Collaborators
Start Date Phases
NCT02243644 Recruiting Neurocysticercosis All India Institute of Medical Sciences, New Delhi March 2014 Phase 3
NCT02102321 Recruiting Hookworm Stool Burden|Anemia|Exercise Tolerance Salmon, Margaret, M.D.|Akeso Associates|Bill and Melinda Gates Foundation|Eastern Congo Initiative|HEAL Hospital, DRC March 2014 --
NCT01903057 Withdrawn Trachoma|Lymphatic Filariasis Emory University February 2014 Phase 4
NCT02032043 Recruiting Lymphatic Filariasis|Onchocerciasis|Soil Transmitted Helminth (STH) Infections Washington University School of Medicine February 2014 --
NCT01748929 Active, not recruiting Intestinal Diseases, Parasitic McGill University Health Center February 2014 Phase 4

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Chemical Information

Download Albendazole SDF
Molecular Weight (MW) 265.33
Formula

C12H15N3O2S

CAS No. 54965-21-8
Storage 3 years -20℃Powder
6 months-80℃in DMSO
Synonyms
Solubility (25°C) * In vitro DMSO 17 mg/mL (64 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Research Area

Tech Support & FAQs

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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