Catalog No.S1640 Synonyms: SKF-62979

Albendazole Chemical Structure

Molecular Weight(MW): 265.33

Albendazole is a member of the benzimidazole compounds used as a drug indicated for the treatment of a variety of worm infestations.

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In DMSO USD 130 In stock
USD 97 In stock
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  • Dose-dependent disruption in the distribution of α-tubulin following exposure to albendazole. Experimental treatments included vehicle (DMSO), 0.1 μM, 0.5 μM and 1 μM albendazole for 24 hours. α-tubulin was visualized using immunofluorescence (green) and nuclei were stained with DAPI (blue). 40x fluorescence microscopy was used to assess changes in cellular morphology and tubulin distribution.

    Oncotarget, 2017, 8(42): 71512-71519. Albendazole purchased from Selleck.

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Biological Activity

Description Albendazole is a member of the benzimidazole compounds used as a drug indicated for the treatment of a variety of worm infestations.
tubulin [1]
In vitro

Albendazole is reported to be teratogenic in rats, and is extensively metabolized to the sulfoxide derivative. Albendazole and its sulfoxide metabolite elicit an accumulation of cells in the mitotic phase of the cell cycle. [1]

In vivo Albendazole causes an induction of hepatic activities of CYP1A1-associated ethoxyresorufin O-deethylase (EROD) 65 fold, CYP1A2-associated methoxyresorufin O-demethylase (MROD) 6 fold, CYP2B1-associated penthoxyresorufin O-dealkylase (PROD) 4 fold, CYP2B2-associated benzyloxyresorufin O-dealkylase (BROD) 14 fold, as well as a partial reduction of CYP2E1-associated 4-nitrophenol hydroxylase (4-NPH) activity in the rat. [2] Albendazole is metabolized to its pharmacologically active sulfoxide metabolites by liver and lung microsomes from sheep and cattle, as well as by cattle intestinal microsomes. [3] Albendazole (ABZ) is a benzimidazole derivative with a broad spectrum of activity against human and animal helminthe parasites. [4] Albendazole and its metabolites are extensively distributed to the digestive tract, mainly into the abomasal fluid, after the i.v. and i.r. administrations. Albendazole and its active albendazole sulphoxide (ABZSO) metabolite are recovered in tapeworms collected from both i.v. and i.r. treated lambs. [5]


Solubility (25°C)

In vitro DMSO 17 mg/mL (64.07 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 265.33


CAS No. 54965-21-8
Storage powder
Synonyms SKF-62979

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00375583 Completed Lymphatic Filariasis|Wuchereria Bancrofti Infection National Institute of Allergy and Infectious Diseases (NIAID)|Tuberculosis Research Centre, India|National Institutes of Health Clinical Center (CC) September 9, 2006 Phase 2
NCT00339417 Completed Lymphatic Filariasis National Institute of Allergy and Infectious Diseases (NIAID)|National Institutes of Health Clinical Center (CC) February 22, 2006 Phase 2
NCT03014167 Not yet recruiting Helminthiasis|Filariasis Natural History Museum, United Kingdom|Bill and Melinda Gates Foundation|University of Washington|Imperial College London|London School of Hygiene and Tropical Medicine|Institut de Recherche Clinique du Bénin (IRCB)|Institut de Recherche pour le Developpement|Christian Medical College, Vellore, India|Blantyre Institute for Community Ophthalmology (BICO)|Swiss Tropical & Public Health Institute March 2017 Phase 4
NCT03036059 Not yet recruiting Lymphatic Filariasis|Helminth Infection Noguchi Memorial Institute for Medical Research|Ghana Health Services March 2017 Phase 4
NCT02636803 Not yet recruiting Helminthiasis Robert Gilman|Universidad Peruana Cayetano Heredia|Johns Hopkins Bloomberg School of Public Health February 2017 Phase 2
NCT03032042 Not yet recruiting Helminth Infection Francis I. Proctor Foundation January 2017 Phase 4

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Microtubule Associated Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID