Vinorelbine Tartrate

Catalog No.S4269

Vinorelbine Tartrate is a semi-synthetic vinca alkaloid, and inhibits mitosis through interaction with tubulin.

Price Stock Quantity  
USD 117 In stock
USD 227 In stock
USD 397 In stock
Bulk Inquiry

Massive Discount Available

Free Overnight Delivery on all orders over $ 500.

Vinorelbine Tartrate Chemical Structure

Vinorelbine Tartrate Chemical Structure
Molecular Weight: 1079.11

Validation & Quality Control

2 customer reviews :

Quality Control & MSDS

Product Information

  • Compare Microtubule Associated Inhibitors
    Compare Microtubule Associated Products
  • Research Area

Product Description

Biological Activity

Description Vinorelbine Tartrate is a semi-synthetic vinca alkaloid, and inhibits mitosis through interaction with tubulin.
Targets Tubulin [1]
(Cell-free assay)
In vitro Vinorelbine inhibits microtubule assembly by inducing tubulin aggregation into spirals and paracrystals. [1] Vinorelbine shows potent antiproliferative activity against a series of tumor cells, including human melanoma, non-small-cell lung cancer, breast cancer, etc. [2][3][4]
In vivo In vivo, Vinorelbine also shows antitumour activity against a series of subcutaneously-implanted human tumour xenografts. [5]
Features A semi-synthetic vinca alkaloid as an anti-mitotic chemotherapy drug.

Protocol(Only for Reference)

Animal Study: [5]

Animal Models Bladder (BXF1299), pancreas (PAXF546), kidney (RXF944LX), colon (DLD-1, HT-29, TC37), central nervous system (SF-295), small cell lung (NCI-H69) and prostate (PC-3) xenografts.
Formulation Sterile 0.9% sodium chloride solution
Dosages ~10 mg/kg
Administration i.p.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDog
Weight (kg)
Body Surface Area (m2)0.0070.0250.
Km factor36128520
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)


[1] Fellous A, et al. Semin Oncol. 1989, 16(2 Suppl 4), 9-14.

[2] Photiou A, et al. J Cancer Res Clin Oncol. 1992, 118(4), 249-254.

view more

Clinical Trial Information( data from, updated on 2016-07-30)

NCT Number Recruitment Conditions Sponsor
Start Date Phases
NCT02574455 Not yet recruiting Breast Cancer Immunomedics, Inc. July 2016 Phase 3
NCT02802748 Not yet recruiting Breast Cancer SOLTI Breast Cancer Research Group|Pierre Fabre Laboratories July 2016 Phase 0
NCT02768415 Not yet recruiting Breast Cancer Chinese Academy of Medical Sciences June 2016 Phase 2
NCT02795884 Not yet recruiting NSCLC Yonsei University June 2016 Phase 3
NCT02733380 Recruiting Diffuse Large B-cell Lymphoma Henan Cancer Hospital May 2016 Phase 2

view more

Chemical Information

Download Vinorelbine Tartrate SDF
Molecular Weight (MW) 1079.11


CAS No. 125317-39-7
Storage 3 years -20℃powder
2 years -80℃in solvent
Synonyms N/A
Solubility (25°C) * In vitro DMSO 100 mg/mL (92.66 mM)
Water 100 mg/mL warming (92.66 mM)
Ethanol 100 mg/mL warming (92.66 mM)
In vivo
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Name 3',4'-Didehydro-4'-deoxy-C'-norvincaleukoblastine ditartrate

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

* Indicates a Required Field

Related Microtubule Associated Products

  • TAI-1

    TAI-1 is a potent and specific Hec1 inhibitor, which disrupts Hec1-Nek2 protein interaction.

  • Docetaxel Trihydrate

    Docetaxel, an analog of paclitaxel, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules.

  • Combretastatin A4

    Combretastatin A4 is a microtubule-targeting agent that binds β-tubulin with Kd of 0.4 μM.Phase 3.

  • Paclitaxel

    Paclitaxel is a microtubule polymer stabilizer with IC50 of 0.1 pM in human endothelial cells.

  • Docetaxel

    Docetaxel, an analog of paclitaxel, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules.

  • Vincristine sulfate

    Vincristine sulfate is an inhibitor of polymerization of microtubules by binding to tubulin with IC50 of 32 μM in a cell-free assay.

  • Nocodazole

    Nocodazole is a rapidly-reversible inhibitor of microtubule polymerization, also inhibits Abl, Abl(E255K) and Abl(T315I) with IC50 of 0.21 μM, 0.53 μM and 0.64 μM in cell-free assays, respectively.

  • Vinblastine

    Vinblastine inhibits microtubule formation and suppresses nAChR activity with IC50 of 8.9 μM in a cell-free assay, used to treat certain kinds of cancer.

  • Cabazitaxel

    Cabazitaxel is a semi-synthetic derivative of a natural taxoid.

    Features:A semi-synthetic derivative of a natural taxoid.

  • Epothilone B (EPO906, Patupilone)

    Epothilone B (EPO906, Patupilone) is a paclitaxel-like microtubule-stabilizing agent with EC0.01 of 1.8 μM. Phase 2.

Recently Viewed Items

Tags: buy Vinorelbine Tartrate | Vinorelbine Tartrate supplier | purchase Vinorelbine Tartrate | Vinorelbine Tartrate cost | Vinorelbine Tartrate manufacturer | order Vinorelbine Tartrate | Vinorelbine Tartrate distributor
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Contact Us