Vinorelbine Tartrate

Catalog No.S4269

Vinorelbine Tartrate Chemical Structure

Molecular Weight(MW): 1079.11

Vinorelbine Tartrate is a semi-synthetic vinca alkaloid, and inhibits mitosis through interaction with tubulin.

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USD 117 In stock
USD 227 In stock
USD 397 In stock

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2 Customer Reviews

  • JQ1 and chemotherapeutics (vinorelbine, docetaxel, cisplatin and carboplatin) cooperate to induce apoptosis. MDA-MB-231 and HS578T were exposed to drugs alone and in combination with JQ1, at the indicated doses. Apoptosis was examined after 72 hours of treatment by flow cytometry using Annexin V/ PI staining as previously described.

    Mol Cancer Ther, 2016, 15(8):1823-33.. Vinorelbine Tartrate purchased from Selleck.

    Activity of vinorelbine in NSCLC cell lines in cell viability assay. Activity of vinorelbine NCI-H23, NCI-H460, and NCC44 cell lines in a Cell Titer Glo cell viability assay. Cells were treated with increasing drug concentrations from 0-10000 nM. The data are plotted as the mean % of control cells against the corresponding drug concentration.

     

    Cynthia Bernia from McGill University. Vinorelbine Tartrate purchased from Selleck.

Purity & Quality Control

Choose Selective Microtubule Associated Inhibitors

Biological Activity

Description Vinorelbine Tartrate is a semi-synthetic vinca alkaloid, and inhibits mitosis through interaction with tubulin.
Features A semi-synthetic vinca alkaloid as an anti-mitotic chemotherapy drug.
Targets
Tubulin [1]
(Cell-free assay)
In vitro

Vinorelbine inhibits microtubule assembly by inducing tubulin aggregation into spirals and paracrystals. [1] Vinorelbine shows potent antiproliferative activity against a series of tumor cells, including human melanoma, non-small-cell lung cancer, breast cancer, etc. [2][3][4]

In vivo In vivo, Vinorelbine also shows antitumour activity against a series of subcutaneously-implanted human tumour xenografts. [5]

Protocol

Animal Research:[5]
+ Expand
  • Animal Models: Bladder (BXF1299), pancreas (PAXF546), kidney (RXF944LX), colon (DLD-1, HT-29, TC37), central nervous system (SF-295), small cell lung (NCI-H69) and prostate (PC-3) xenografts.
  • Formulation: Sterile 0.9% sodium chloride solution
  • Dosages: ~10 mg/kg
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (92.66 mM)
Water 100 mg/mL warmed (92.66 mM)
Ethanol 100 mg/mL warmed (92.66 mM)
In vivo

* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 1079.11
Formula

C45H54N4O8.2C4H6O6

CAS No. 125317-39-7
Storage powder
in solvent
Synonyms N/A

Bio Calculators

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02954055 Not yet recruiting Breast Cancer International Breast Cancer Study Group May 2017 Phase 2
NCT02991482 Not yet recruiting Pleural Mesothelioma Malignant Advanced European Thoracic Oncology Platform|Merck Sharp & Dohme Corp.|Frontier Science Foundation, Hellas April 2017 Phase 3
NCT02998528 Recruiting Non Small Cell Lung Cancer Bristol-Myers Squibb January 2017 Phase 3
NCT02897986 Not yet recruiting Pediatric Cancer Assistance Publique Hopitaux De Marseille January 2017 Phase 1
NCT02574455 Not yet recruiting Breast Cancer Immunomedics, Inc. December 2016 Phase 3
NCT03007992 Recruiting Metastatic Breast Cancer Johannes Gutenberg University Mainz|Pierre Fabre Pharma GmbH December 2016 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Microtubule Associated Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID