Paclitaxel (Taxol)

M.Wt: 853.91
Formula: C₄₇H₅₁NO₁₄
Solubility: DMSO
Purity: >99%
Storage: at -20℃ 2 years
CAS No.: 33069-62-4

Price and Availability of Paclitaxel (Taxol):

Applications & Customer's Feedback of Paclitaxel (Taxol):

Fabrication of biologically active surface-modified Taxol nanowires using anodic aluminum oxide templates.  ------ Mohamed H. Abumaree,Lingyan Zhu,et al. RSC Adv.2011; 1:884-892

Biological Activity of Paclitaxel (Taxol):

Paclitaxel is a microtubule polymer stabilizer with an IC50 of 0.1 pM for human endothelial cells. It selectively inhibits the proliferation of human endothelial cells (ECs) at ultra low concentrations (0.1-100 pM), while it inhibits non-endothelial type human cells at 10(4) - to 10(5) -fold higher concentrations, with IC50 = 1-10 nM. The selectivity of paclitaxel inhibition of cell proliferation is also species specific, as mouse ECs are not sensitive to paclitaxel at ultra low concentrations. They are inhibited by higher concentrations of paclitaxel with IC50 = 1-10 nM. Inhibition of human ECs by paclitaxel at ultra low concentrations does not affect the cellular microtubule structure. Paclitaxel blocks cells in G2-M, and this may result in a schedule-dependent effect on paclitaxel cytotoxicity. ^[1][2][3]

References on Paclitaxel (Taxol):

[1] http://en.wikipedia.org/wiki/Paclitaxel

[2] Georgiadis MS et al. Clin Cancer Res. 1997 Mar;3(3):449-54.

[3] Wang J et al. Anticancer Drugs. 2003 Jan;14(1):13-9.

MSDS
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