Paclitaxel

Catalog No.S1150 Synonyms: NSC 125973

Paclitaxel Chemical Structure

Molecular Weight(MW): 853.91

Paclitaxel is a microtubule polymer stabilizer with IC50 of 0.1 pM in human endothelial cells.

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5 Customer Reviews

  • (F) Kaplan-Meier curves are shown for all groups described: no hydrogel, a hydrogel loaded with paclitaxel, or a hydrogel loaded with doxorubicin. The number of mice per group (n) and median survival (ms) are listed. The experiment was performed at least three times.

    Science, 2018, 10(433), doi: 10.1126/scitranslmed.aar1916. Paclitaxel purchased from Selleck.

    Characterization of nuclear damage by PARP as DNA damage repair marker. CLSM images of dual drug conjugated nanoparticle treatments to HeLa cells for 24 h at their respective IC50 drug dosages compared to nontreated control. Cells were stained with PARP-Alexafluor 488 antibody (green).

    ACS Appl Mater Interfaces, 2015, 7(14): 7584-98. Paclitaxel purchased from Selleck.

  • Inhibitory effect of lenvatinib and paclitaxel on the proliferation of ATC cells. Cells were treated with the indicated concentrations of lenvatinib (A) and paclitaxel (B) for 48 h, followed by MTT assay to evaluate cell proliferation. IC50 values of these two drugs for each cell line were calculated using the Reed-Muench method

    Am J Cancer Res, 2017, 7(4):903-912. Paclitaxel purchased from Selleck.

    Western blot analysis of pPRAS40 (T246), pS6 (S240/S244), and pS6 (S235/S236) proteins in (A) HeyA8 cells and (B) SKOV3 cells treated with 0.37 μM or 10 μM paclitaxel in three-dimensional cell culture for 24 hours.

    PLoS One, 2016, 11(5):e0155052. . Paclitaxel purchased from Selleck.

  • Microscope image (406) magnification of U937 cells after exposure to SM-TNs. a) Untreated U937 cells. b) U937 cells treated with 200 nM, and 35 nM ODS empty shells. c) U937 cells treated with microcrystalline (free) Taxol prepared by sonicating Taxol in 20%H3PO4/0.8% SDS solution. d) U937 cells treated with 200 nM SM-TN. A SM-TN is seen in the middle of the picture. e) U937 cells treated with 35 nM SMTN.The nanowires are too small to see at this magnification, but their effect on the cells is clearly visible. Scale bar = 10 mm.

    RSC Adv 2011 1, 884-892. Paclitaxel purchased from Selleck.

Purity & Quality Control

Choose Selective Microtubule Associated Inhibitors

Biological Activity

Description Paclitaxel is a microtubule polymer stabilizer with IC50 of 0.1 pM in human endothelial cells.
Targets
Microtubule (human endothelial cells) [1]
0.1 pM
In vitro

Paclitaxel inhibits non-endothelial type human cells at 104 - to 105 -fold higher concentrations, with IC50 of 1 nM-10 nM. The selectivity of Paclitaxel inhibition of cell proliferation is also species specific, as mouse ECs are not sensitive to Paclitaxel at ultra low concentrations. Inhibition of human ECs by Paclitaxel at ultra low concentrations does not affect the cellular microtubule structure, and the treated cells do not show G2/M cell cycle arrest and apoptosis, suggesting a novel but as yet unidentified mechanism of action. In an in vitro angiogenesis assay, Paclitaxel at ultra low concentrations blocks human ECs from forming sprouts and tubes in the three-dimensional fibrin matrix. [1] In the presence of SMF, the efficient concentration of Paclitaxel on K562 cells is decreased from 50 to 10 ng/mL. The cell cycle arrest effect of Paclitaxel with or without SMF on K562 cells is correlated with DNA damage. [2] Paclitaxel alone causes a time-dependent inhibition of CDK1 in four cell lines including A549 cells, H358, H1395 cells and H1666 cells. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
TE-15 M4Tl[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2j3SmlEPTB;MD6wNFAzQDdizszN NGTKN4ZUSU6JRWK=
LC-2-ad MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmPOTWM2OD1yLkCwNFMyPyEQvF2= MWjTRW5ITVJ?
RL95-2 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\lSWlEPTB;MD6wNFA3PjhizszN NIDFc5pUSU6JRWK=
MZ1-PC Mo\IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF2zNGFKSzVyPUCuNFAxPzJ7IN88US=> NXTqcmxzW0GQR1XS
TE-8 M3rwNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2W1Z2lEPTB;MD6wNFEyPyEQvF2= NWX5epV5W0GQR1XS
SW954 M{eySmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4DYWGlEPTB;MD6wNFEyQSEQvF2= MknuV2FPT0WU
TE-11 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2faR2lEPTB;MD6wNFEzOyEQvF2= MVHTRW5ITVJ?
PSN1 M1PRVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFXKO5NKSzVyPUCuNFAyOyEQvF2= Mk\tV2FPT0WU
MOLT-4 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M37nUWlEPTB;MD6wNFE1QSEQvF2= MX\TRW5ITVJ?
697 M{TIZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\1OXhFUUN3ME2wMlAxOTVizszN MYHTRW5ITVJ?
ETK-1 NXjXNpBMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MonaTWM2OD1yLkCwNVUzKM7:TR?= MkHOV2FPT0WU
TE-10 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3jUdmlEPTB;MD6wNFE2PCEQvF2= NGfBUYZUSU6JRWK=
HUTU-80 MnjBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3HI[2lEPTB;MD6wNFE3QCEQvF2= M1XBfnNCVkeHUh?=
NTERA-S-cl-D1 M1nDPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUHBVWM1UUN3ME2wMlAxOjB7IN88US=> M4qwe3NCVkeHUh?=
MFH-ino MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4XvUmlEPTB;MD6wNFI3QCEQvF2= MXfTRW5ITVJ?
IA-LM NHT6d3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTBwMECyPEDPxE1? M2XPenNCVkeHUh?=
MC116 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn[4TWM2OD1yLkCwNlg6KM7:TR?= MVrTRW5ITVJ?
RKO NHHEWXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTBwMECyPVgh|ryP MYrTRW5ITVJ?
MRK-nu-1 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3ryPGlEPTB;MD6wNFI6QSEQvF2= MlXPV2FPT0WU
VA-ES-BJ M3:1V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1fCb2lEPTB;MD6wNFMh|ryP MV3TRW5ITVJ?
KALS-1 NEKzT49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MonhTWM2OD1yLkCwN|A5KM7:TR?= NWHQfI9IW0GQR1XS
BB30-HNC MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3ex[mlEPTB;MD6wNFMyPCEQvF2= NG\OOnhUSU6JRWK=
ACN NGLtTYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XQSGlEPTB;MD6wNFMyPiEQvF2= MUDTRW5ITVJ?
TE-9 NHm2b5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlzJTWM2OD1yLkCwN|I3KM7:TR?= MXfTRW5ITVJ?
SIG-M5 NIr2cWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NInzd3FKSzVyPUCuNFA{OjdizszN NHvC[ZRUSU6JRWK=
no-10 NXvPPVFET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnKbpd{UUN3ME2wMlAxOzZ{IN88US=> MoHoV2FPT0WU
EW-1 Mor3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGrGe4pKSzVyPUCuNFA{PzFizszN NWj4VIN5W0GQR1XS
SK-LMS-1 Mk\RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn\rTWM2OD1yLkCwOFAyKM7:TR?= MmjSV2FPT0WU
GT3TKB NXTWXok6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTBwMEC0N|Qh|ryP MYPTRW5ITVJ?
ES4 NWH5b2hDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEHFZZRKSzVyPUCuNFA1PDlizszN NYXiOWRxW0GQR1XS
IMR-5 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MonITWM2OD1yLkCwOFUh|ryP MoHTV2FPT0WU
NCI-H1648 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3fH[2lEPTB;MD6wNFQ3QSEQvF2= MofoV2FPT0WU
MV-4-11 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVu3[lhwUUN3ME2wMlAxPDd3IN88US=> M13INnNCVkeHUh?=
SK-UT-1 MmfTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTBwMEC0PEDPxE1? NHTseWNUSU6JRWK=
NB13 NYXvZZBPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTBwMEC0PVEh|ryP NHHBfGJUSU6JRWK=
DJM-1 NUDob|dJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTBwMEC1N{DPxE1? NVnHWpJyW0GQR1XS
ES8 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTBwMEC1N|gh|ryP MnLBV2FPT0WU
TE-6 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUnRNVBZUUN3ME2wMlAxPTdizszN MmHFV2FPT0WU
KS-1 NEjnc4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmfOTWM2OD1yLkCwOVgzKM7:TR?= MlqxV2FPT0WU
TE-1 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIfudVlKSzVyPUCuNFA3ODZizszN MYrTRW5ITVJ?
ATN-1 NI\IT5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRTBwMEC2NFkh|ryP NIH4[4hUSU6JRWK=
A4-Fuk M{\Z[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYOwc|NZUUN3ME2wMlAxPjFzIN88US=> Mn;jV2FPT0WU
ALL-PO MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWTJR|UxRTBwMEC2N{DPxE1? NIC4RXVUSU6JRWK=
BE-13 NInTcmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYS1XWxVUUN3ME2wMlAxPjN4IN88US=> M2LpOXNCVkeHUh?=
KM12 NVTT[nVnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MljITWM2OD1yLkCwOlM4KM7:TR?= MlLUV2FPT0WU
NOS-1 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUjIbWdGUUN3ME2wMlAxPjVizszN NYfDfXhWW0GQR1XS
SW962 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTBwMEC2OlIh|ryP NWTSXWJ[W0GQR1XS
OCUB-M NGCyWJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3jUWmlEPTB;MD6wNFY3OiEQvF2= MWfTRW5ITVJ?
NCI-H510A NFTFPFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTBwMEC2OlUh|ryP MmKxV2FPT0WU
EW-16 MnjRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIDjbWlKSzVyPUCuNFA3QTRizszN MnLEV2FPT0WU
KGN MoDMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHn6c41KSzVyPUCuNFA4OTJizszN NInVPGtUSU6JRWK=
LS-411N NFq2fHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWmyU3VZUUN3ME2wMlAxPzF5IN88US=> NH;tV|VUSU6JRWK=
Becker MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlPxTWM2OD1yLkCwO|Ih|ryP MkjvV2FPT0WU
HC-1 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEP3UXFKSzVyPUCuNFA4OjFizszN M3P5UnNCVkeHUh?=
CESS MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnTQTWM2OD1yLkCwO|M4KM7:TR?= NFH3XXhUSU6JRWK=
KURAMOCHI MnnZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFHXcnZKSzVyPUCuNFA4PDhizszN NWXsdWIyW0GQR1XS
TGBC24TKB NILqUJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\2TWM2OD1yLkCwO|UzKM7:TR?= NFzyTIRUSU6JRWK=
SW982 NXrIWVNTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3fue2lEPTB;MD6wNFc3PiEQvF2= NUXKcXp6W0GQR1XS
HCE-4 M1zhPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2nGXmlEPTB;MD6wNFc3PyEQvF2= NHzkUoZUSU6JRWK=
LOUCY MlPJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGm5TVlKSzVyPUCuNFA4PzVizszN NEjGbHRUSU6JRWK=
8-MG-BA MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVPNNo1oUUN3ME2wMlAxPzl4IN88US=> NXexSWxmW0GQR1XS
HT-144 NVTuXZZPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTBwMEC4JO69VQ>? NGnpWZBUSU6JRWK=
LXF-289 NWDBNXI{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPsTWM2OD1yLkCwPFE5KM7:TR?= MX\TRW5ITVJ?
RS4-11 M4Xsbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTBwMEC4N|Yh|ryP NXT0OoJ7W0GQR1XS
DEL M37Ndmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTBwMEC4OFUh|ryP MX7TRW5ITVJ?
OCI-AML2 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkDXTWM2OD1yLkCwPFUzKM7:TR?= NYToOYxWW0GQR1XS
CCRF-CEM NUS0bHVjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1;lT2lEPTB;MD6wNFg4OSEQvF2= NHTkfm9USU6JRWK=
A388 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTBwMEC4O|Qh|ryP MnXOV2FPT0WU
KNS-42 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M32yb2lEPTB;MD6wNFg6OSEQvF2= MVHTRW5ITVJ?
OVCAR-4 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2PJTGlEPTB;MD6wNFkxPCEQvF2= MnnFV2FPT0WU
NCI-H1355 M{CyUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGPmW2hKSzVyPUCuNFA6OTRizszN MknuV2FPT0WU
BL-70 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGftcXdKSzVyPUCuNFA6OyEQvF2= NGLXOVBUSU6JRWK=
BL-41 M320T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4XGcGlEPTB;MD6wNFk{PCEQvF2= MX7TRW5ITVJ?
A101D NU\BdYY4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUHJUXV{UUN3ME2wMlAxQTZizszN NHLhe4VUSU6JRWK=
HL-60 M{jkVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYn3fINMUUN3ME2wMlAxQTZ4IN88US=> NEPYWpNUSU6JRWK=
COR-L279 M1fI[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTBwMEC5PVkh|ryP MVzTRW5ITVJ?
NCI-SNU-16 NEWxVYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlnnTWM2OD1yLkCxNFA5KM7:TR?= NVnvTJo3W0GQR1XS
Calu-6 MojwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXfufIs2UUN3ME2wMlAyODF{IN88US=> NX23NFlxW0GQR1XS
SR MkLnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1j2ZmlEPTB;MD6wNVAzPiEQvF2= MlW0V2FPT0WU
QIMR-WIL NV7uXoRPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWrJR|UxRTBwMEGwN|Mh|ryP M4roenNCVkeHUh?=
LB647-SCLC Mo[0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnHCTWM2OD1yLkCxNFUyKM7:TR?= NVrMPZFRW0GQR1XS
RPMI-8226 NVXGUYtHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;oUWlEPTB;MD6wNVExOiEQvF2= MoP2V2FPT0WU
SK-PN-DW NIrHTmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTBwMEGxNVIh|ryP NXP5d3J2W0GQR1XS
SF268 NUK5UGo1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIjNSGpKSzVyPUCuNFEyPTFizszN M13MVXNCVkeHUh?=
HD-MY-Z MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTBwMEGxOlMh|ryP MYjTRW5ITVJ?
DOHH-2 NXS0VZV2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTBwMEGyNFMh|ryP NUfv[5FpW0GQR1XS
SCC-3 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPFd5pVUUN3ME2wMlAyOjB2IN88US=> MWjTRW5ITVJ?
ST486 M{XES2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYHScZV5UUN3ME2wMlAyOjB2IN88US=> M{KxTXNCVkeHUh?=
NALM-6 M3OwW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MknYTWM2OD1yLkCxNlE1KM7:TR?= NWn3ZWd6W0GQR1XS
NCI-H1436 MnHGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3nPNWlEPTB;MD6wNVI{OSEQvF2= M3O5enNCVkeHUh?=
KE-37 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlPSTWM2OD1yLkCxNlM1KM7:TR?= NED5O|VUSU6JRWK=
RPMI-8402 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXeyTJFkUUN3ME2wMlAyOjV4IN88US=> MoT3V2FPT0WU
RXF393 NYHiVXZPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnHPTWM2OD1yLkCxNlU4KM7:TR?= NHXUW3VUSU6JRWK=
KARPAS-45 NGjLTnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXy2S5N[UUN3ME2wMlAyOjdizszN M4nPb3NCVkeHUh?=
HOP-62 NY\RcnF4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGDTdnRKSzVyPUCuNFEzPzZizszN MYjTRW5ITVJ?
ES1 NFHnZ|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\xZ2lEPTB;MD6wNVI5QCEQvF2= MoTEV2FPT0WU
L-363 NU[y[XNOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mni4TWM2OD1yLkCxN|UyKM7:TR?= NEX2VXhUSU6JRWK=
GI-1 NVHRe3BYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYPJR|UxRTBwMEGzO|Mh|ryP NV7ZR5M2W0GQR1XS
CTV-1 NI\TW4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEe4Um5KSzVyPUCuNFE1PzhizszN NWPJU282W0GQR1XS
TE-5 NVTq[FZ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGHONGVKSzVyPUCuNFE1QTZizszN MYXTRW5ITVJ?
SNU-C2B NXrhZll3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1HkUGlEPTB;MD6wNVQ6PiEQvF2= NHXsPIxUSU6JRWK=
K-562 MnW2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2fjemlEPTB;MD6wNVUyPiEQvF2= NWq2dohYW0GQR1XS
SNB75 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTBwMEG1OEDPxE1? NVXuW|lSW0GQR1XS
MOLT-13 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn61TWM2OD1yLkCxOlM4KM7:TR?= M4LX[XNCVkeHUh?=
LS-123 NXzEVYxFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2XWVmlEPTB;MD6wNVY3PCEQvF2= MlrQV2FPT0WU
NCI-SNU-5 NF;COVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1PjdWlEPTB;MD6wNVcxOSEQvF2= NVPmfoxVW0GQR1XS
Daudi MknWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTBwMEG3NFgh|ryP NVj3UW91W0GQR1XS
A253 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTBwMEG3N|gh|ryP NYLiWlk1W0GQR1XS
TGBC1TKB NF71XmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTBwMEG3OVIh|ryP M4C0[HNCVkeHUh?=
SJSA-1 MnruS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWfMXZNpUUN3ME2wMlAyPzZ5IN88US=> NUm5boFnW0GQR1XS
NCCIT NUTSSFloT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jzcmlEPTB;MD6wNVc3QSEQvF2= M4DTT3NCVkeHUh?=
NCI-H69 M2XMXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUW3clh[UUN3ME2wMlAyPzd6IN88US=> NEXqUItUSU6JRWK=
SH-4 Mkj1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFLiUYNKSzVyPUCuNFE5QTVizszN MUfTRW5ITVJ?
HCC1187 NW\4O4VWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M33ROGlEPTB;MD6wNVkzPCEQvF2= M1PIZnNCVkeHUh?=
HCC1599 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{j4ZWlEPTB;MD6wNlAzKM7:TR?= M1HKZ3NCVkeHUh?=
ONS-76 NUO5bnRMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFq3N5BKSzVyPUCuNFIxOzZizszN MYTTRW5ITVJ?
KU812 NVvUO45jT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjSTWM2OD1yLkCyNFM6KM7:TR?= NVH5cGRFW0GQR1XS
ML-2 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4XiNWlEPTB;MD6wNlA1PyEQvF2= MYDTRW5ITVJ?
HCE-T NFO4W4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTBwMEKwPVIh|ryP MWfTRW5ITVJ?
NCI-H446 MlP2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTBwMEKxNVIh|ryP NUXVbJY2W0GQR1XS
RPMI-6666 NWTHNGRLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXzJR|UxRTBwMEKxOFkh|ryP MkDZV2FPT0WU
MOLT-16 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTBwMEKxOVMh|ryP NVrnWGxmW0GQR1XS
JiyoyeP-2003 MkX4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4i2fGlEPTB;MD6wNlE4PiEQvF2= MYnTRW5ITVJ?
MHH-PREB-1 M13RVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTBwMEKxPVEh|ryP MVHTRW5ITVJ?
MC-CAR NYXDZWtNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWTyc2I5UUN3ME2wMlAzOzJ4IN88US=> NIfWPXRUSU6JRWK=
BC-3 NHzlfW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NInSb45KSzVyPUCuNFI{PDRizszN MnTNV2FPT0WU
KINGS-1 M3jsZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2PvWWlEPTB;MD6wNlM2PSEQvF2= M3P2dHNCVkeHUh?=
PF-382 M2TOZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4PoOmlEPTB;MD6wNlM4QCEQvF2= MmjXV2FPT0WU
J-RT3-T3-5 NFTl[plIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXfy[|NRUUN3ME2wMlAzOzh|IN88US=> M{TpcHNCVkeHUh?=
SF539 M1LleWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3nLfmlEPTB;MD6wNlQxOSEQvF2= Mn2wV2FPT0WU
LB831-BLC NUfHdZFDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4DRNWlEPTB;MD6wNlQ5PSEQvF2= MkPWV2FPT0WU
DMS-114 NUnNPIgxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVTzSoN3UUN3ME2wMlAzPTB{IN88US=> NYnaUo5SW0GQR1XS
LB1047-RCC NIXPb5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTBwMEK1NUDPxE1? NFziZ|NUSU6JRWK=
LB771-HNC NHvNdHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY\JR|UxRTBwMEK1N|Qh|ryP NXK2O4pFW0GQR1XS
BB65-RCC NVexSpZVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHjYeZNKSzVyPUCuNFI2OzRizszN NWHyeZU{W0GQR1XS
BV-173 NUXsT2lMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnnyTWM2OD1yLkCyOVU1KM7:TR?= MWjTRW5ITVJ?
ARH-77 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1zBUmlEPTB;MD6wNlYxOSEQvF2= NGnhNmxUSU6JRWK=
IST-MEL1 MkLhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFX1VXdKSzVyPUCuNFI3OjNizszN NVezS3pnW0GQR1XS
NB1 MnvHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTBwMEK2PFch|ryP NH23OYpUSU6JRWK=
EoL-1-cell M3nUNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEG0UHVKSzVyPUCuNFI3QDhizszN Mo\iV2FPT0WU
KY821 M3vT[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\K[Y5rUUN3ME2wMlAzPjl5IN88US=> M3fJR3NCVkeHUh?=
CMK MlrTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1TaSGlEPTB;MD6wNlc{PCEQvF2= NWrq[W1YW0GQR1XS
NCI-H2126 M2DVXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWLub|kyUUN3ME2wMlAzPzZ6IN88US=> M4exbXNCVkeHUh?=
NCI-H526 NF20S5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MojLTWM2OD1yLkCyPFkyKM7:TR?= MWHTRW5ITVJ?
COLO-684 MlvTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlLGTWM2OD1yLkCyPVA5KM7:TR?= NIjs[o1USU6JRWK=
NCI-H747 NUTWVHVCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;hdGZKSzVyPUCuNFI6OzNizszN MWXTRW5ITVJ?
JAR MonXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUHvNINtUUN3ME2wMlAzQTR4IN88US=> M4exbnNCVkeHUh?=
MEG-01 NFnUWphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTBwMEK5O|gh|ryP NIizOo1USU6JRWK=
MONO-MAC-6 M{HNcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTBwMEOwNlMh|ryP M3nYTnNCVkeHUh?=
IST-SL1 NV\se2tmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHfU[G5KSzVyPUCuNFMxPDJizszN MXnTRW5ITVJ?
CPC-N NXvaNVVRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXzJR|UxRTBwMEOwO|kh|ryP M3j4VHNCVkeHUh?=
NCI-H1963 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTBwMEOxN|Eh|ryP MWjTRW5ITVJ?
K052 NGqxfHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXDPZRKSzVyPUCuNFMzPDdizszN MkLSV2FPT0WU
KM-H2 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTBwMEOzNFch|ryP M37YfnNCVkeHUh?=
TE-12 MmjSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX3rfWl3UUN3ME2wMlA{OzB7IN88US=> NEnFOG1USU6JRWK=
TK10 MnT4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlXtTWM2OD1yLkCzN|U3KM7:TR?= MljZV2FPT0WU
NMC-G1 NH;xWohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHzsdlFKSzVyPUCuNFM1PTJizszN Moi4V2FPT0WU
no-11 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2fGNmlEPTB;MD6wN|Q4QCEQvF2= M3mxR3NCVkeHUh?=
NCI-H524 MkfMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{D0O2lEPTB;MD6wN|UzQSEQvF2= NVjIZ2NWW0GQR1XS
MHH-CALL-2 Mn3oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\wRWtNUUN3ME2wMlA{PTZ{IN88US=> NYfQXW1{W0GQR1XS
GB-1 M4TVOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVvJR|UxRTBwMEO2JO69VQ>? NFrpbYZUSU6JRWK=
OPM-2 NYnHbZlqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEjGU5RKSzVyPUCuNFM3PzNizszN M2LxfnNCVkeHUh?=
RH-1 M1XBVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEXJSm1KSzVyPUCuNFM5OTlizszN MmPuV2FPT0WU
NCI-H64 M3jFNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTBwMEO4OVch|ryP M4PHOHNCVkeHUh?=
EVSA-T MkDIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFzob4NKSzVyPUCuNFM6OjNizszN M{PGUnNCVkeHUh?=
KARPAS-299 NVvVT5FFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF3tdFJKSzVyPUCuNFM6QCEQvF2= MnS1V2FPT0WU
MZ7-mel MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXzG[|ljUUN3ME2wMlA1ODRizszN MVPTRW5ITVJ?
LB373-MEL-D Mmn6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnzRTWM2OD1yLkC0NVA2KM7:TR?= M2WyR3NCVkeHUh?=
HEL MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXTCd2FUUUN3ME2wMlA1OTRizszN MlvnV2FPT0WU
SW872 NXLSeJIxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vBRmlEPTB;MD6wOFIyKM7:TR?= NV\DS4ZxW0GQR1XS
DU-4475 Ml\3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTBwMESyOFQh|ryP MnHUV2FPT0WU
IST-SL2 NHnVZ2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTBwMESyO|Uh|ryP NVjOe3YzW0GQR1XS
NCI-H82 M2XBNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH3pSoZKSzVyPUCuNFQ{ODdizszN M4TQRnNCVkeHUh?=
LC4-1 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFG4ZWFKSzVyPUCuNFQ{PTFizszN MVzTRW5ITVJ?
HDLM-2 NVjpS3lZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVrBWI5EUUN3ME2wMlA1Ozl{IN88US=> MmfzV2FPT0WU
MMAC-SF NHfsRmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTBwMES1N|Qh|ryP NV\ONphyW0GQR1XS
L-540 M17pUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUS0Z3FLUUN3ME2wMlA1PjN7IN88US=> NXrSUGdNW0GQR1XS
MZ2-MEL MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlrTTWM2OD1yLkC0O|QzKM7:TR?= NVexVW5WW0GQR1XS
LU-134-A NEW3bYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{DtTmlEPTB;MD6wOFc4OyEQvF2= MX\TRW5ITVJ?
UACC-257 NH3LXlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXPudXFrUUN3ME2wMlA1QDR7IN88US=> NWT2VWlpW0GQR1XS
NCI-H1581 M4W5W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX3oWVBQUUN3ME2wMlA1QTV|IN88US=> MYrTRW5ITVJ?
NB17 M{S0Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFz0dW5KSzVyPUCuNFQ6PzlizszN MkP3V2FPT0WU
SBC-1 NUjKfmh6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVjsZ3dIUUN3ME2wMlA2ODR{IN88US=> NHTiPIhUSU6JRWK=
TALL-1 NYjB[HBWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoD2TWM2OD1yLkC1NFQ2KM7:TR?= Mk[4V2FPT0WU
NCI-H1304 NI\yV2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml7kTWM2OD1yLkC1NlA5KM7:TR?= MnPSV2FPT0WU
NEC8 NVfrV|EyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE\xZpZKSzVyPUCuNFUzQDZizszN Ml3QV2FPT0WU
CAL-148 M{DLWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXHIT5lKUUN3ME2wMlA2PDN7IN88US=> NXW4T|lTW0GQR1XS
CGTH-W-1 M3Hufmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTBwMEW0OFkh|ryP NUDFcGFNW0GQR1XS
NCI-H889 MlfYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXzuVZN{UUN3ME2wMlA2PTl{IN88US=> M1TEWXNCVkeHUh?=
GR-ST M4fnVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIPlSHpKSzVyPUCuNFU3OjFizszN M{ntNHNCVkeHUh?=
KARPAS-422 M1nMN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MluwTWM2OD1yLkC1OlUh|ryP NHLkcHFUSU6JRWK=
RPMI-8866 M2H6T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWLJR|UxRTBwMEW3NVIh|ryP M1HrNnNCVkeHUh?=
SCLC-21H NYrlVVlGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1nkTmlEPTB;MD6wOVg5PCEQvF2= NHTNfIVUSU6JRWK=
COR-L88 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4XBUmlEPTB;MD6wOVkzPyEQvF2= NFu0elBUSU6JRWK=
LU-139 MnHCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTBwMEW5PFYh|ryP M1TkNnNCVkeHUh?=
SF126 NYTxSmVvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTBwME[xN|Mh|ryP MkThV2FPT0WU
NCI-H1882 NVXrfWozT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIXLfplKSzVyPUCuNFY1OjRizszN MnvyV2FPT0WU
EW-24 NFuxOnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1iwNmlEPTB;MD6wOlQ5OyEQvF2= MVPTRW5ITVJ?
CP67-MEL NFridGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFixSI1KSzVyPUCuNFY5OSEQvF2= NG\Qe4hUSU6JRWK=
DG-75 MmPDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{e4XGlEPTB;MD6wOlg6QSEQvF2= NX7Weos{W0GQR1XS
LOXIMVI MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVrHZYdyUUN3ME2wMlA4ODJ6IN88US=> NXLaSWl1W0GQR1XS
HH MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEnHdJpKSzVyPUCuNFcyPTdizszN MnnPV2FPT0WU
K5 NV;QcIU2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1SzdmlEPTB;MD6wO|IzPiEQvF2= M4GwPXNCVkeHUh?=
EC-GI-10 NFzNRXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTBwMEeyOVch|ryP MV\TRW5ITVJ?
SK-N-DZ M1rhTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTBwMEezNFch|ryP NXz4SYNjW0GQR1XS
A3-KAW MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2W2PGlEPTB;MD6wO|M2OSEQvF2= M3XPTXNCVkeHUh?=
MLMA NIrQTVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnWzTWM2OD1yLkC3OFY2KM7:TR?= M1uyR3NCVkeHUh?=
LB996-RCC MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWDGcFBxUUN3ME2wMlA4PzB5IN88US=> MVvTRW5ITVJ?
OS-RC-2 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYfKdVlTUUN3ME2wMlA4PzR6IN88US=> Mnn3V2FPT0WU
CTB-1 M33XT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkPtTWM2OD1yLkC3PFEh|ryP NW\Ye4NpW0GQR1XS
IST-MES1 NIHXcGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGL6O2VKSzVyPUCuNFc6OTJizszN NH;XcZJUSU6JRWK=
LS-1034 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlrVTWM2OD1yLkC4NFM2KM7:TR?= MYfTRW5ITVJ?
HT MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnHXTWM2OD1yLkC4NFg3KM7:TR?= MmjvV2FPT0WU
NCI-H2141 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M17vNGlEPTB;MD6wPFEh|ryP M{HFS3NCVkeHUh?=
LB2518-MEL NUPU[Xg4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVXJR|UxRTBwMEixOFEh|ryP M3SwSnNCVkeHUh?=
GI-ME-N NXL0SXVUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTBwMEi0OVIh|ryP Ml63V2FPT0WU
TGW M2TQOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYWxW4FOUUN3ME2wMlA5PjB5IN88US=> NVfNc5lKW0GQR1XS
SK-NEP-1 Mkn4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1jvS2lEPTB;MD6wPFY1OSEQvF2= NUnSZ4xNW0GQR1XS
NOMO-1 NGjyWopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFy3Rm9KSzVyPUCuNFkzPzVizszN M4nmUnNCVkeHUh?=
ES6 NYXEd5dkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH\FVHRKSzVyPUCuNFk2QDlizszN NUX6UZZsW0GQR1XS
NCI-H209 MlK1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1:1NWlEPTB;MD6wPVc5PiEQvF2= NEnUS2ZUSU6JRWK=
GAK MlXTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2DYTWlEPTB;MD6xNFE3KM7:TR?= MlXOV2FPT0WU
BC-1 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MonpTWM2OD1yLkGwN|YyKM7:TR?= M{Sx[XNCVkeHUh?=
KLE MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;HTWM2OD1yLkGwOFQ{KM7:TR?= MXjTRW5ITVJ?
EW-3 MoDjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{DjdmlEPTB;MD6xNFk5KM7:TR?= MWXTRW5ITVJ?
NKM-1 NWW2WWVJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTBwMUGxJO69VQ>? NVW0R2dDW0GQR1XS
D-336MG MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2XuUGlEPTB;MD6xNVI1PCEQvF2= M17VUnNCVkeHUh?=
NB69 MlPQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4HkVWlEPTB;MD6xNVMxOSEQvF2= NXLIV2ZqW0GQR1XS
D-263MG M2P1XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{W1UGlEPTB;MD6xNVcyOiEQvF2= NHru[lJUSU6JRWK=
KP-N-YS NFfZR|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYLGPVZ1UUN3ME2wMlEzOjlzIN88US=> NXjFVIZ1W0GQR1XS
NCI-H1155 M3W3Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mme4TWM2OD1yLkGyOVU5KM7:TR?= NXfNUFh[W0GQR1XS
BOKU NYDBUolXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYLnUZFMUUN3ME2wMlEzPTd7IN88US=> Mo\6V2FPT0WU
LAMA-84 MoLWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1HMOWlEPTB;MD6xNlk6KM7:TR?= MorwV2FPT0WU
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NCI-H345 NVTYWVM{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{TzZ2lEPTB;MD6xOlkzQCEQvF2= MUnTRW5ITVJ?
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EHEB MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2jMVWlEPTB;MD6zPVA5PSEQvF2= NVfTNmxJW0GQR1XS
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SHP-77 Mk\MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXHsZ|JuUUN3ME2wMlQ4QDV3IN88US=> M3TRcHNCVkeHUh?=
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... Click to View More Cell Line Experimental Data

In vivo The inhibition rations of Paclitaxel alone on BC-V and BC-ER tumors are 49.78% and 51.23%, respectively. Treatment of six cycles of 20 mg/kg Paclitaxel significantly reduces the percentages of Ki-67-positive cells to 20.4% in BC-V tumors and 25.1% in BC-ER tumors, respectively. [4]

Protocol

Cell Research:

[1]

+ Expand
  • Cell lines: Cells including human neonatal dermal microvascular ECs (HMVECs), human umbilical vein ECs (HUVECs), human umbilical artery ECs (HUAVECs), normal human astrocytes (NHAs), normal human dermal fibroblasts (NHDFs), normal human epidermal keratinocytes (NHEKs
  • Concentrations: 0.1-100 pM
  • Incubation Time: 72 hours
  • Method:

    Cells including human neonatal dermal microvascular ECs (HMVECs), human umbilical vein ECs (HUVECs), human umbilical artery ECs (HUAVECs), normal human astrocytes (NHAs), normal human dermal fibroblasts (NHDFs), normal human epidermal keratinocytes (NHEKs), human mammary epithelial cells (HMEpCs), human prostate epithelial cells (PrEpCs) and human umbilical artery smooth muscle cells (UASMCs) are cultured. Cell proliferations are performed in 96-well plates using cells between passages 6 and 12. Cells are seeded at 3000–5000 cells/well and allowed to attach for 4 hours. Paclitaxel, diluted in culture medium, is added in quadruplicate wells and the cells ae incubated for 3 days before MTS reagents are added to quantitate the live cells in each well.


    (Only for Reference)
Animal Research:

[5]

+ Expand
  • Animal Models: Female, 20-22 g homozygous nude athymic mice with BC-V and BC-ER tumors
  • Formulation: Dissolved in absolute ethanol with an equal volume of cremophor and diluted 1:4 with sterile physiological saline before use.
  • Dosages: 20 mg/kg
  • Administration: Administered via i.v.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 171 mg/mL (200.25 mM)
Ethanol 18 mg/mL (21.07 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
5% DMSO+5% Tween 80+ddH2O
For best results, use promptly after mixing.
2.5mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 853.91
Formula

C47H51NO14

CAS No. 33069-62-4
Storage powder
in solvent
Synonyms NSC 125973

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
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    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
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    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

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To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03519971 Recruiting Non-Small Cell Lung Cancer AstraZeneca April 9 2018 Phase 3
NCT03432598 Recruiting Locally Advanced or Metastatic Lung Cancer BeiGene August 9 2017 Phase 2
NCT03275818 Recruiting Tumor Desmoplastic Small Round Cell Adult|Tumor Desmoplastic Small Round Cell Childhood|Sarcoma Ewing|Sarcoma|Desmoid Grupo Espanol de Investigacion en Sarcomas May 9 2017 Phase 2
NCT03117933 Recruiting Ovarian Cancer University of Oxford|AstraZeneca March 9 2017 Phase 2
NCT02775435 Recruiting Non-small Cell Lung Cancer Merck Sharp & Dohme Corp. June 9 2016 Phase 3
NCT02613208 Active not recruiting Breast Cancer Hoffmann-La Roche December 9 2015 --

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    I am interested in the product S1150 for in vivo studies, could you please give some suggestions for the formulation?

  • Answer:

    S1150 in 1% DMSO+30% polyethylene glycol+1% Tween 80 at 30mg/ml is a suspension. If the you want to inject it, there is another vehicle, 5% DMSO+5% Tween 80+ddH2O. S1150 can dissolve in it at 2.5mg/ml as a clear solution. It is a common formulation we used, but is not cited from reference.

  • Question 2:

    the compound was dissolved into 1ml DMSO and diluted with 1x PBS or water (500ul + 9.5 ml PBS or water). I found the white precipitation goes out. How to figure it out?

  • Answer:

    Paclitaxel has very low solubility in water based solution and that's why it precipitated out once you dilute the stock with water. The vehicle we suggest is: 1% DMSO+30% polyethylene glycol+1% Tween 80.

Microtubule Associated Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID