Buy Paclitaxel (Taxol) | Microtubule Associated Inhibitors & Chemicals | Price | IC50

Validation & Quality Control

Product Citations(4)

Am J Physiol Heart Circ Physiol, 2012, 302(11):H2211-9

BMC Cancer, 2012, 12, 541

Bioorg Med Chem, 2012, 21(4), 922-931

RSC Adv, 2011, 1, 884-892

Customer Reviews(1) in vivo invitation

Quality Control & MSDS

Related Compound Libraries

Paclitaxel (Taxol) is available in the following compound libraries:

Inhibitor Library (96-well) FDA Approved Drug Library (96-well) Chemotherapeutic Agent Library (96-well) Chemical Library (96-well) Cambridge Cancer Compound Library(96-well)

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Dr. Antonino Maria Sparta demonstrates a breakthrough in leukemia research by utilizing two inhibitors produced by Selleck Chemicals.

Cat.No.	Product Name	Solubility (25°C)
S1150	Paclitaxel (Taxol)	<1 mg/mL	171 mg/mL	18 mg/mL
S1148	Docetaxel (Taxotere)	<1 mg/mL	162 mg/mL	162 mg/mL
S1241	Vincristine	60 mg/mL	100 mg/mL	<1 mg/mL
S1364	Epothilone B (EPO906)	<1 mg/mL	102 mg/mL	102 mg/mL
S2775	Nocodazole	<1 mg/mL	7 mg/mL	<1 mg/mL
S1165	ABT-751	<1 mg/mL	74 mg/mL	12 mg/mL
S1297	Epothilone A	<1 mg/mL	99 mg/mL	99 mg/mL
S2195	CYT997	<1 mg/mL	87 mg/mL	20 mg/mL
S2209	Vinflunine Tartrate	193 mg/mL	193 mg/mL	193 mg/mL

Product Description

Biological Activity Protocol Chemical Information Customer Reviews Product Citations Tech Support & FAQs

Biological Activity

Description	Paclitaxel (Taxol, Onxol, Nov-Onxol) is a microtubule polymer stabilizer with IC50 of 0.1 pM in human endothelial cells.
Targets	Microtubule (human endothelial cells)
IC50	0.1 pM ^[1]
In vitro	Paclitaxel inhibits non-endothelial type human cells at 10⁴ - to 10⁵ -fold higher concentrations, with IC50 of 1 nM-10 nM. The selectivity of Paclitaxel inhibition of cell proliferation is also species specific, as mouse ECs are not sensitive to Paclitaxel at ultra low concentrations. Inhibition of human ECs by Paclitaxel at ultra low concentrations does not affect the cellular microtubule structure, and the treated cells do not show G2/M cell cycle arrest and apoptosis, suggesting a novel but as yet unidentified mechanism of action. In an in vitro angiogenesis assay, Paclitaxel at ultra low concentrations blocks human ECs from forming sprouts and tubes in the three-dimensional fibrin matrix. ^[1] In the presence of SMF, the efficient concentration of Paclitaxel on K562 cells is decreased from 50 to 10 ng/mL. The cell cycle arrest effect of Paclitaxel with or without SMF on K562 cells is correlated with DNA damage. ^[2] Paclitaxel alone causes a time-dependent inhibition of CDK1 in four cell lines including A549 cells, H358, H1395 cells and H1666 cells. ^[3]
In vivo	The inhibition rations of Paclitaxel alone on BC-V and BC-ER tumors are 49.78% and 51.23%, respectively. Treatment of six cycles of 20 mg/kg Paclitaxel significantly reduces the percentages of Ki-67-positive cells to 20.4% in BC-V tumors and 25.1% in BC-ER tumors, respectively. ^[4]
Clinical Trials	Paclitaxel has entered in a Phase III clinical trial for the treatment of tubular breast cancer stage II, mucinous breast cancer stage II, breast cancer female NOS and invasive ductal breast cancer.
Features

Protocol(Only for Reference)

Cell Assay: ^[1]

Cell lines	Cells including human neonatal dermal microvascular ECs (HMVECs), human umbilical vein ECs (HUVECs), human umbilical artery ECs (HUAVECs), normal human astrocytes (NHAs), normal human dermal fibroblasts (NHDFs), normal human epidermal keratinocytes (NHEKs), human mammary epithelial cells (HMEpCs), human prostate epithelial cells (PrEpCs) and human umbilical artery smooth muscle cells (UASMCs)
Concentrations	0.1-100 pM
Incubation Time	72 hours
Method	Cells including human neonatal dermal microvascular ECs (HMVECs), human umbilical vein ECs (HUVECs), human umbilical artery ECs (HUAVECs), normal human astrocytes (NHAs), normal human dermal fibroblasts (NHDFs), normal human epidermal keratinocytes (NHEKs), human mammary epithelial cells (HMEpCs), human prostate epithelial cells (PrEpCs) and human umbilical artery smooth muscle cells (UASMCs) are cultured. Cell proliferations are performed in 96-well plates using cells between passages 6 and 12. Cells are seeded at 3000–5000 cells/well and allowed to attach for 4 hours. Paclitaxel, diluted in culture medium, is added in quadruplicate wells and the cells ae incubated for 3 days before MTS reagents are added to quantitate the live cells in each well.

Animal Study: ^[4]

Animal Models	Female, 20-22 g homozygous nude athymic mice with BC-V and BC-ER tumors
Formulation	Control
Dosages	20 mg/kg
Administration	Administered via i.v.

1

References

Chemical Information

Download Paclitaxel (Taxol) SDF

Molecular Weight (MW)	853.91
Formula	C₄₇H₅₁NO₁₄
CAS No.	33069-62-4, 157069-30-2, 1203669-79-7
Synonyms	N/A

Solubility (25°C) DMSO 171 mg/mL Water <1 mg/mL Ethanol 18 mg/mL
Storage	2 years -20°CPowder
	2 weeks4°Cin DMSO
	6 months-80°Cin DMSO

Chemical Name	Benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-

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Customer Reviews (1)

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Source

RSC Adv , 2011, 1, 884-892. Paclitaxel (Taxol) purchased from Selleck

Method

Microscope image

Cell Lines

U937 cells

Concentrations

Incubation Time

24 h

Results

The ODS-treated cells in Fig. b looked identical to the untreated cells in Fig. a with a similar rate of natural cell death of less than 3%. When Taxol microcrystals are added to the cell culture (the standard way that Taxol is released into biological systems), decreased cell proliferation rate, pronounced swelling and vacuolization are observed, as shown in Fig. c.

Product Citations (4)

TGFβ/TNFα-Mediated Epithelial-Mesenchymal Transition Generates Breast Cancer Stem Cells with a Claudin-Low Phenotype. [Suwanabol PA, et al. Am J Physiol Heart Circ Physiol 2012;302(11):H2211-9]
PubMed: 22447946
The downregulation of Mcl-1 via USP9X inhibition sensitizes solid tumors to Bcl-xl inhibition. [Peddaboina C, et al. BMC Cancer 2012;12, 541]
PubMed: 23171055
Development, validation and pilot screening of an in vitro multi-cellular three-dimensional cancer spheroid assay for anti-cancer drug testing. [Rati Lama, et al. Bioorg Med Chem 2012;21(4), 922-931]
PubMed: 23306053

Fabrication of biologically active surface-modified Taxol nanowires using anodic aluminum oxide templates. [Abumaree MH, et al. RSC Adv 2011;1, 884-892]

Tech Support & FAQs

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Epothilone A
Epothilone A is a Taxol-like microtubule-stabilizing agent with EC_0.01 of 2 μM.
Epothilone B (EPO906)

Epothilone B is a Taxol-like microtubule-stabilizing agent with EC_0.01 of 1.8 μM.
CYT997
CYT997 is a potent tubulin polymerization inhibitor with IC50 of ~3 μM.
Vinflunine Tartrate
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Wortmannin
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Paclitaxel (Taxol)

Validation & Quality Control

Product Citations(4)

Customer Reviews(1) in vivo invitation

Quality Control & MSDS

Related Compound Libraries

Paclitaxel (Taxol) is available in the following compound libraries:

Product Information

Compare Microtubule Associated Inhibitors & Chemicals

Research Area

Product Description

Biological Activity

Protocol(Only for Reference)

Cell Assay: ^[1]

Animal Study: ^[4]

References

Chemical Information

Research Area

Customer Reviews (1)

Product Citations (4)

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Recently Viewed Items

Cat.No.	Product Name	Solubility (25°C)
Cat.No.	Product Name	Water	DMSO	Ethanol
S1150	Paclitaxel (Taxol)	<1 mg/mL	171 mg/mL	18 mg/mL
S1148	Docetaxel (Taxotere)	<1 mg/mL	162 mg/mL	162 mg/mL
S1241	Vincristine	60 mg/mL	100 mg/mL	<1 mg/mL
S1364	Epothilone B (EPO906)	<1 mg/mL	102 mg/mL	102 mg/mL
S2775	Nocodazole	<1 mg/mL	7 mg/mL	<1 mg/mL
S1165	ABT-751	<1 mg/mL	74 mg/mL	12 mg/mL
S1297	Epothilone A	<1 mg/mL	99 mg/mL	99 mg/mL
S2195	CYT997	<1 mg/mL	87 mg/mL	20 mg/mL
S2209	Vinflunine Tartrate	193 mg/mL	193 mg/mL	193 mg/mL

Choose Your Country or Region

Product Categories

Paclitaxel (Taxol)

Validation & Quality Control

Product Citations(4)

Customer Reviews(1) in vivo invitation

Quality Control & MSDS

Related Compound Libraries

Paclitaxel (Taxol) is available in the following compound libraries:

Product Information

Compare Microtubule Associated Inhibitors & Chemicals

Research Area

Product Description

Biological Activity

Protocol(Only for Reference)

Cell Assay: [1]

Animal Study: [4]

References

Chemical Information

Research Area

Customer Reviews (1)

Product Citations (4)

Tech Support & FAQs

If you have any other enquiries, please leave a message.

Related Microtubule Associated Inhibitors & Chemicals

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Cell Assay: ^[1]

Animal Study: ^[4]