Product Categories

Docetaxel (Taxotere)

Docetaxel, an analog of taxol, is an inhibitor of depolymerisation of microtubules through binding to stabilized microtubules.

Catalog No.S1148
Price Stock Quantity  
USD 70 In stock
USD 270 In stock
Contact Us Bulk Inquiry Add to Wishlist

Free Overnight Delivery on all orders over $ 500.

Order now and get it on

Tel: +1-832-582-8158[email protected]

Docetaxel (Taxotere) Chemical Structure
Molecular Weight: 807.88

Validation & Quality Control

Quality Control & MSDS

Related Compound Libraries

Docetaxel (Taxotere) is available in the following compound libraries:

Cambridge Cancer Compound Library(96-well) Chemical Library (96-well) Chemotherapeutic Agent Library (96-well) FDA Approved Drug Library (96-well) Inhibitor Library (96-well)

Product Information

  • Compare Microtubule Associated Inhibitors & Chemicals
    Compare Microtubule Associated Inhibitors & Chemicals
  • Research Area

Product Description

Biological Activity Protocol Chemical Information Tech Support & FAQs

Biological Activity

Description Docetaxel, an analog of taxol, is an inhibitor of depolymerisation of microtubules through binding to stabilized microtubules.
Targets Microtubules
IC50
In vitro Docetaxel is a cytotoxic agent, especially for proliferating cells, which is related to its ability to promote the formation of microtubule bundles and induce sustained mitotic arrest, followed by apoptosis of mitotically arrested cells or permanent mitotic block. Docetaxel suppresses microtubule dynamic instability as well as tread-milling, resulting in the failure of chromosomes to segregate to the daughter cells, which in turn triggers premature exit from mitosis rather than a block at this phase of the cell cycle. [2] Docetaxel inhibits the clonogenic survival of Human cancer cell Hs746T (stomach), AGS (stomach), HeLa (cervix), CaSki (cervix), BxPC3 (pancreas), Capan-1 (pancreas) with IC50 of 1 nM, 1 nM, 0.3 nM, 0.3 nM, 0.3 nM and 0.3 nM respectively. [4] Docetaxel inhibits endothelial cell migration that does not affects microtubule gross morphology or inhibit cell proliferation, although they does produce more subtle effects on microtubule dynamics. Docetaxel inhibits HUVEC migration with an observed IC50 of 1 pM. HUVEC chemotaxis stimulated by either of two angiogenic factors, thymidine phosphorylase or VEGF, is inhibited by Docetaxel with IC 50 of 10 pM and is ablated at 1 nM. [7] Docetaxel induces human monocytes, but not RAW 264.7 murine macrophages, Prostaglandin H Synthase-2m (PGHS-2) expression. [8]
In vivo Docetaxel (33 mg/kg/dose, given i.v. every 4 days for 3 injections) results in a tumor growth delay of 19.3 days in M2OL2 colon xenografts. Docetaxel also shows great antitumor activities in MX-1, SK-MEL-2, LX-1 and OVCAR-3 xenografts. Docetaxel inhibits the angiogenic response to fibroblast growth factor 2 with IC 50 of 5.4 mg/kg when injected twice weekly over a 14-day period, and angiogenesis is completely blocked in mice that receives 10 mg/kg Docetaxel. Docetaxel has selectivity for endothelial cell migration and/or microvessel formation because infiltration of inflammatory cells into the Matrigel plug is much less sensitive to inhibition by Docetaxel. [7]
Clinical Trials A phase III trial of six cycles of Docetaxel+Hormonal treatment versus hormonal treatment in patients with intermediate or high-risk prostate cancer is in recruiting.
Features

Protocol(Only for Reference)

Cell Assay: [5]

Cell lines Human gastric cancer cell lines MKN-28
Concentrations 6 nM
Incubation Time 3 days
Method 2000 cells in 180 μL of medium are seeded in a 96-well plate, and 20 μL of drug solution is simultaneously added in triplicate to each well. The plate is incubated for 3 days at 37°C in a humidified atmosphere of 5% CO2. On day 3, 25 μL of MTT reagent is added to each well. After 4 h of incubation, the medium is removed by aspiration. 0.2 mL of dimethylsulphoxide (DMSO) is added to each well and thoroughly mixed by using a mechanical plate mixer to dissolve the resulting MTT-formazan crystals. Absorbance at 540 nm (OD) is measured by a reader.

Animal Study: [6]

Animal Models Human colon carcinomas xenografts CX-1
Formulation 50 mg/mL stock solution in ethanol by adding an equal volume of polysorbate 80 and diluting with 5% dextrose in water to the final volume
Dosages 33 mg/kg
Administration i.v. every 4 days for 3 injections
1

References

Chemical Information

Download Docetaxel (Taxotere) SDF
Molecular Weight (MW) 807.88
Formula

C43H53NO14
CAS No. 114977-28-5, 148408-66-6 (3H2O)
Synonyms N/A
Solubility (25°C)
  • DMSO 162 mg/mL
  • Water <1 mg/mL
  • Ethanol 162 mg/mL
Storage 2 years -20°CPowder
2 weeks4°Cin DMSO
6 months-80°Cin DMSO
Chemical Name Benzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-
Molarity Calculator Dilution Calculator Molecular Weight Calculator

Research Area

Tech Support & FAQs

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions
Tel: +1-832-582-8158 Ext:3Monday–Friday 9:00 AM–5:00 PM (Central Time)

If you have any other enquiries, please leave a message.

* Indicates a Required Field

Related Microtubule Associated Inhibitors & Chemicals

  • ABT-751

    ABT-751 (E7010) binds to the colchicine site on β-tubulin and inhibits polymerization of microtubules.

  • Epothilone A

    Epothilone A is a Taxol-like microtubule-stabilizing agent with EC0.01 of 2 μM.

  • Epothilone B (EPO906)

    Epothilone B is a Taxol-like microtubule-stabilizing agent with EC0.01 of 1.8 μM.

  • CYT997

    CYT997 is a potent tubulin polymerization inhibitor with IC50 of ~3 μM.

  • Vinflunine Tartrate

    Vinflunine is a new vinca alkaloid uniquely fluorinated with the properties of mitotic-arresting and tubulin-interacting activity.

  • Nocodazole

    Nocodazole inhibits Abl, Abl(E255K) and Abl(T315I) with IC50 of 0.21 μM, 0.53 μM and 0.64 μM, respectively.

  • Elesclomol

    Elesclomol (STA-4783) is a novel potent oxidative stress inducer that illicits pro-apoptosis events among tumor cells..

  • AUY922 (NVP-AUY922)

    NVP-AUY922 (VER-52296) is a highly potent HSP90 inhibitor for HSP90α and HSP90β with IC50 of 13 nM and 21 nM, respectively.

  • PCI-24781

    PCI-24781 (CRA-024781) is a novel broad spectrum HDAC inhibitor targeting HDAC1, HDAC2, HDAC3, HDAC6, HDAC8 and HDAC10 with Ki of 7 nM, 19 nM, 8.2 nM, 17 nM, 280 nM, 24 nM, respectively.

  • 17-AAG (Tanespimycin)

    17-AAG (Tanespimycin) is a potent HSP90 inhibitor with IC50of 5 nM.

Recently Viewed Items

Tags: buy Docetaxel (Taxotere) | Docetaxel (Taxotere) ic50 | Docetaxel (Taxotere) price | Docetaxel (Taxotere) cost | Docetaxel (Taxotere) solubility dmso | Docetaxel (Taxotere) purchase | Docetaxel (Taxotere) manufacturer | Docetaxel (Taxotere) research buy | Docetaxel (Taxotere) order | Docetaxel (Taxotere) mouse | Docetaxel (Taxotere) chemical structure | Docetaxel (Taxotere) mw | Docetaxel (Taxotere) molecular weight | Docetaxel (Taxotere) datasheet | Docetaxel (Taxotere) supplier | Docetaxel (Taxotere) in vitro | Docetaxel (Taxotere) cell line | Docetaxel (Taxotere) concentration | Docetaxel (Taxotere) nmr
Contact Us