Docetaxel

Catalog No.S1148 Synonyms: RP56976, NSC 628503

Docetaxel Chemical Structure

Molecular Weight(MW): 807.88

Docetaxel, an analog of paclitaxel, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules.

Size Price Stock Quantity  
In DMSO USD 91 In stock
USD 70 In stock
USD 270 In stock
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5 Customer Reviews

  • Viability of cells after exposure to 0, 10, or 10,000 nM docetaxel, assessed by calcein-AM staining (green, left panels) and ethidium homodimer-1 (red, middle panels).

    Mol Pharmaceutics, 2014, 11: 2040−50. Docetaxel purchased from Selleck.

    TNBC and non-TNBC cells were treated for 6 d with the specified concentrations of docetaxel (doc) alone, TTK inhibitor (TTKi) alone or the combinations. The survival of cells was measured using the MTS/MTA assay. ***P<0.001 comparing the combination with single agents and with non-TNBC cell lines.

    Oncogenesis, 2014, 3: e100 . Docetaxel purchased from Selleck.

  • J Transl Med 2013 0.6. Docetaxel purchased from Selleck.

    J Transl Med 2013 0.6. Docetaxel purchased from Selleck.

  • Cell cycle study of percent cell populations in various phases after treatment with vehicle, HCI-2509 in increasing concentrations and docetaxel alone and in combination with HCI-2509 using (a) PC3 cells. Student's unpaired t-tests, using GraphPad Prism software, were used to calculate two-tailed P-values for each experiment to determine statistical significance between untreated and treated samples. The statistically significant P-values are labeled in each figure with an asterisk. (Replicated two more times, representative graph shown).

    Prostate Cancer Prostatic Dis, 2016, 19(4):349-357. Docetaxel purchased from Selleck.

Purity & Quality Control

Choose Selective Microtubule Associated Inhibitors

Biological Activity

Description Docetaxel, an analog of paclitaxel, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules.
Targets
Microtubules [1]
(Cell-free assay)
In vitro

Docetaxel is a cytotoxic agent, especially for proliferating cells, which is related to its ability to promote the formation of microtubule bundles and induce sustained mitotic arrest, followed by apoptosis of mitotically arrested cells or permanent mitotic block. Docetaxel suppresses microtubule dynamic instability as well as tread-milling, resulting in the failure of chromosomes to segregate to the daughter cells, which in turn triggers premature exit from mitosis rather than a block at this phase of the cell cycle. [2] Docetaxel inhibits the clonogenic survival of Human cancer cell Hs746T (stomach), AGS (stomach), HeLa (cervix), CaSki (cervix), BxPC3 (pancreas), Capan-1 (pancreas) with IC50 of 1 nM, 1 nM, 0.3 nM, 0.3 nM, 0.3 nM and 0.3 nM respectively. [4] Docetaxel inhibits endothelial cell migration that does not affects microtubule gross morphology or inhibit cell proliferation, although they does produce more subtle effects on microtubule dynamics. Docetaxel inhibits HUVEC migration with an observed IC50 of 1 pM. HUVEC chemotaxis stimulated by either of two angiogenic factors, thymidine phosphorylase or VEGF, is inhibited by Docetaxel with IC 50 of 10 pM and is ablated at 1 nM. [7] Docetaxel induces human monocytes, but not RAW 264.7 murine macrophages, Prostaglandin H Synthase-2m (PGHS-2) expression. [8]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HSC-3 M4fhS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1fDSWlEPTB;MD6wNFAyOzJizszN M{nLSHNCVkeHUh?=
5637 MkPZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWfIdFdrUUN3ME2wMlAxODF2MzFOwG0> NUT3fHQyW0GQR1XS
HT-144 NX3IdYFDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3LoRWlEPTB;MD6wNFAyPTdizszN MVzTRW5ITVJ?
NCI-H292 Mk\KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLwTWM2OD1yLkCwNFE2QSEQvF2= Ml;hV2FPT0WU
HCE-T MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTBwMECwNVYzKM7:TR?= MWnTRW5ITVJ?
ESS-1 NYSwe2pCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYTyOYd{UUN3ME2wMlAxODF5OTFOwG0> NXXSNVlpW0GQR1XS
D-566MG M2\rT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlj1TWM2OD1yLkCwNFE5OiEQvF2= MYfTRW5ITVJ?
CAL-62 M{Kxe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWnPWWZ[UUN3ME2wMlAxODF6NTFOwG0> NXjyWHc{W0GQR1XS
GT3TKB M4jvc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLkd49KSzVyPUCuNFAxOjN{IN88US=> MoH2V2FPT0WU
HSC-4 M4HzTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2LId2lEPTB;MD6wNFAzOzlizszN NFzz[lVUSU6JRWK=
KOSC-2 NHz5T4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmXVTWM2OD1yLkCwNFI2PSEQvF2= M1W2WHNCVkeHUh?=
NB14 NXK3bWRZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYTUXpdpUUN3ME2wMlAxODJ4IN88US=> M4XFXHNCVkeHUh?=
ES8 M2PBOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\OXGlEPTB;MD6wNFAzPiEQvF2= NUKyT2lYW0GQR1XS
BFTC-905 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mmi0TWM2OD1yLkCwNFI3QCEQvF2= NXz6W2t3W0GQR1XS
A498 NYrVdGVzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{j1O2lEPTB;MD6wNFAzPzhizszN Mm\EV2FPT0WU
HO-1-N-1 MnexS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTBwMECwNlgyKM7:TR?= MXHTRW5ITVJ?
SF539 M1LvSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHfTRlRKSzVyPUCuNFAxOzB{IN88US=> MWDTRW5ITVJ?
HuO-3N1 NWrXNWJYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF[2d4FKSzVyPUCuNFAxOzB{IN88US=> NUT3VFR5W0GQR1XS
NCI-H510A MkLaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWfGflV1UUN3ME2wMlAxODN|NjFOwG0> MYDTRW5ITVJ?
CAL-27 NIfkbYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1fpc2lEPTB;MD6wNFA{OzlizszN MX\TRW5ITVJ?
TE-8 NGLmNmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHLQXFNKSzVyPUCuNFAxOzZ4IN88US=> NFyxfllUSU6JRWK=
VA-ES-BJ MorBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4LFe2lEPTB;MD6wNFA{PzVizszN MYHTRW5ITVJ?
RH-1 NFroV5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTvXZVKSzVyPUCuNFAxOzh4IN88US=> NWracXBsW0GQR1XS
COLO-800 NIPDOVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTBwMECwN|g5KM7:TR?= NEPqXnJUSU6JRWK=
ES7 MnnGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIGxN3pKSzVyPUCuNFAxOzh7IN88US=> NUHyV|h1W0GQR1XS
GAMG M1[3U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGTN[mJKSzVyPUCuNFAxPDF4IN88US=> M{jV[XNCVkeHUh?=
Ca9-22 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;PUpZ7UUN3ME2wMlAxODR{MzFOwG0> Mlu4V2FPT0WU
SBC-1 M4SzbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnfrTWM2OD1yLkCwNFQ{KM7:TR?= MXvTRW5ITVJ?
RPMI-7951 NIfPRXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTBwMECwOFQ5KM7:TR?= Mnu3V2FPT0WU
SW1710 NIrE[YhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\3d4o5UUN3ME2wMlAxODR4NjFOwG0> NVXGRXN7W0GQR1XS
HGC-27 Mnq0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHTmS4lKSzVyPUCuNFAxPDdzIN88US=> NE\0XIFUSU6JRWK=
MC-IXC M{TNNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFzF[FhKSzVyPUCuNFAxPDd7IN88US=> NUTpfY01W0GQR1XS
FTC-133 NHj0NZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\mZWlEPTB;MD6wNFA1QDlizszN MWnTRW5ITVJ?
HT-1080 MmrwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY\jUVdjUUN3ME2wMlAxODVyMTFOwG0> NVjlc5puW0GQR1XS
NMC-G1 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHW0XIFKSzVyPUCuNFAxPTF5IN88US=> MnvyV2FPT0WU
GI-1 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIPWfXFKSzVyPUCuNFAxPTJ6IN88US=> M4LEUnNCVkeHUh?=
CGTH-W-1 NFTy[mdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUfBc3dRUUN3ME2wMlAxODV2MjFOwG0> MljMV2FPT0WU
A2058 M{THdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYjJcWoyUUN3ME2wMlAxODV2NDFOwG0> M4HSPHNCVkeHUh?=
ETK-1 MnK5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXrvOGNVUUN3ME2wMlAxODV3ODFOwG0> MX\TRW5ITVJ?
NEC8 M1KxcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3[2NWlEPTB;MD6wNFA2PjFizszN NH73fXhUSU6JRWK=
TE-11 MmftS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4THTWlEPTB;MD6wNFA2PjlizszN MkL4V2FPT0WU
NCI-H720 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NULub3hyUUN3ME2wMlAxODV6IN88US=> NIjzSmlUSU6JRWK=
PSN1 NIOwd5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTBwMECwOVgyKM7:TR?= NUew[4ZQW0GQR1XS
SW780 NX3qcZJKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2rrR2lEPTB;MD6wNFA2QDdizszN MXXTRW5ITVJ?
8-MG-BA M2LvUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTBwMECwOVg6KM7:TR?= NY\R[3VqW0GQR1XS
EC-GI-10 NYrHT495T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoXsTWM2OD1yLkCwNFU6OiEQvF2= MX\TRW5ITVJ?
SJSA-1 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYfJR|UxRTBwMECwOlE2KM7:TR?= MULTRW5ITVJ?
639-V MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2X4TWlEPTB;MD6wNFA3PDdizszN M{XGXHNCVkeHUh?=
PFSK-1 Mmi2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVe4fmFoUUN3ME2wMlAxODZ3NzFOwG0> NGLxZXJUSU6JRWK=
DMS-273 M4DTUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1H0XWlEPTB;MD6wNFA3PzRizszN MUPTRW5ITVJ?
TE-9 NGXvO3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{X2TGlEPTB;MD6wNFA3PzZizszN MWXTRW5ITVJ?
SCC-25 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTBwMECwOlgh|ryP MnjmV2FPT0WU
PA-1 NV\1c5B[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIrMRVhKSzVyPUCuNFAxPjh5IN88US=> M13UO3NCVkeHUh?=
MHH-ES-1 NF7yXFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTBwMECwO{DPxE1? NYTrSpVrW0GQR1XS
Daoy NVS3fJVLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUf5WIZ7UUN3ME2wMlAxODdizszN Mo\FV2FPT0WU
G-402 MkPWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYTJR|UxRTBwMECwO|A3KM7:TR?= MYLTRW5ITVJ?
YKG-1 NYPkRXl1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXmx[llIUUN3ME2wMlAxODdyNzFOwG0> M3HrcnNCVkeHUh?=
Ca-Ski MnrhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1fZfmlEPTB;MD6wNFA4OjhizszN NYfROI1UW0GQR1XS
CHP-212 NF\OWWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYm1UVBTUUN3ME2wMlAxODd|IN88US=> M2rCVXNCVkeHUh?=
SCC-4 NUjHbnE2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;D[|ZqUUN3ME2wMlAxODd|OTFOwG0> NV7nNo1jW0GQR1XS
EW-3 MkLqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYS2R3ZTUUN3ME2wMlAxODd2NTFOwG0> MWHTRW5ITVJ?
P12-ICHIKAWA NELiNlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVTvclBmUUN3ME2wMlAxODd2NTFOwG0> Mmr6V2FPT0WU
HSC-2 NFj1U29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1rMd2lEPTB;MD6wNFA4PTVizszN NHX2dnlUSU6JRWK=
HN Mn:3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlTDTWM2OD1yLkCwNFc2QCEQvF2= M{[1VHNCVkeHUh?=
LXF-289 M4nuc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWHaU5FZUUN3ME2wMlAxODd3ODFOwG0> NH3NWlVUSU6JRWK=
ES1 NUDXWXpjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXzKOoRCUUN3ME2wMlAxODd5IN88US=> MU\TRW5ITVJ?
NTERA-S-cl-D1 NGXVR5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfSTWM2OD1yLkCwNFc4OyEQvF2= NFjJPHZUSU6JRWK=
K5 MnnaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVq0emtrUUN3ME2wMlAxODd5ODFOwG0> MU\TRW5ITVJ?
HOS NYC3[lhJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTBwMECwO|gzKM7:TR?= Mn\JV2FPT0WU
YH-13 MoXaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLTTWM2OD1yLkCwNFc6OSEQvF2= M{jVVXNCVkeHUh?=
SW954 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M13SPWlEPTB;MD6wNFA5OjNizszN NGS2fIFUSU6JRWK=
KYSE-510 MkjjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTBwMECwPFQh|ryP NH25V5RUSU6JRWK=
8505C NWryWVlZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTBwMECwPFU1KM7:TR?= MV;TRW5ITVJ?
A549 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTBwMECwPFgzKM7:TR?= MWrTRW5ITVJ?
Detroit562 M{WxR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHS1NIVKSzVyPUCuNFAxQTB{IN88US=> MULTRW5ITVJ?
ES5 NFq3fVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTBwMECwPVEh|ryP M{C4NnNCVkeHUh?=
KYSE-140 NXqwcnlLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWDYTIY3UUN3ME2wMlAxODl|MzFOwG0> MkfGV2FPT0WU
GMS-10 MkPkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX7NdHMxUUN3ME2wMlAxODl2MTFOwG0> MmfPV2FPT0WU
D-263MG M3vOOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2TGUGlEPTB;MD6wNFA6PDdizszN M3OwTXNCVkeHUh?=
BCPAP Ml\FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnXCTWM2OD1yLkCwNFk1PyEQvF2= M2SxNHNCVkeHUh?=
CHL-1 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NULBboZsUUN3ME2wMlAxODl3ODFOwG0> M1nmNnNCVkeHUh?=
RKO NXrETJZXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmLhTWM2OD1yLkCwNFk5QSEQvF2= MmTtV2FPT0WU
SW48 NHfuU4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\hTWM2OD1yLkCwNVAyKM7:TR?= MUTTRW5ITVJ?
BPH-1 NITFUoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnjYTWM2OD1yLkCwNVAzKM7:TR?= M3PYOHNCVkeHUh?=
EFO-27 NF[1cHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnu0TWM2OD1yLkCwNVAzKM7:TR?= NVOzSZZGW0GQR1XS
CAL-33 NYLXXGRuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTBwMECxNFQh|ryP NXTDOmN6W0GQR1XS
NCI-H1792 NH3jb|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFf6UIRKSzVyPUCuNFAyODRizszN NEj4RZNUSU6JRWK=
BB30-HNC Mm[5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUD2OXZVUUN3ME2wMlAxOTB3IN88US=> NVH3ZY5EW0GQR1XS
VM-CUB-1 NIX1e5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3PPd2lEPTB;MD6wNFExPSEQvF2= NVjlRZVTW0GQR1XS
TE-5 NFrHVI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnr5TWM2OD1yLkCwNVA3KM7:TR?= MmL4V2FPT0WU
NB13 NXHieXZwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vPfWlEPTB;MD6wNFExPyEQvF2= NInyO4xUSU6JRWK=
NBsusSR NFP3NIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTBwMECxNUDPxE1? M2rydHNCVkeHUh?=
LNCaP-Clone-FGC NFfOUHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFzPXlBKSzVyPUCuNFAyOSEQvF2= NX6wNmhKW0GQR1XS
EPLC-272H M1q2Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M13HdmlEPTB;MD6wNFEyOSEQvF2= NUDaSIFJW0GQR1XS
KNS-62 NGnGTJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXfnUXVNUUN3ME2wMlAxOTF{IN88US=> M3TMUHNCVkeHUh?=
RERF-LC-MS MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYD6d2FrUUN3ME2wMlAxOTF|IN88US=> MoGwV2FPT0WU
LOXIMVI MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVfuWYZOUUN3ME2wMlAxOTF4IN88US=> MUDTRW5ITVJ?
KINGS-1 NIHFb3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFfnbIdKSzVyPUCuNFAyOTdizszN NGnnXolUSU6JRWK=
T98G NFrjW2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnzqTWM2OD1yLkCwNVE4KM7:TR?= MojrV2FPT0WU
HCC1806 M37BZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTBwMECxNVgh|ryP MkTOV2FPT0WU
MZ1-PC NGC3V4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF24[mxKSzVyPUCuNFAyOThizszN NUiwZ5I4W0GQR1XS
RT-112 MlXTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH21fopKSzVyPUCuNFAyOTlizszN MXTTRW5ITVJ?
LK-2 MkCzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTBwMECxNlEh|ryP NYDyWJJ7W0GQR1XS
A375 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHXPVW5KSzVyPUCuNFAyOjFizszN MWDTRW5ITVJ?
SF268 NH\sTFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M365RmlEPTB;MD6wNFEzOSEQvF2= NVTTZ49UW0GQR1XS
H9 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVfqb4RLUUN3ME2wMlAxOTJ2IN88US=> M1f4TnNCVkeHUh?=
KYSE-410 Ml;TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTBwMECxNlQh|ryP NHq4WmNUSU6JRWK=
G-401 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4rGdmlEPTB;MD6wNFEzPyEQvF2= MW\TRW5ITVJ?
SW982 MnLOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTBwMECxNlch|ryP Mk\2V2FPT0WU
D-423MG Ml7HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHJR|UxRTBwMECxN{DPxE1? MVfTRW5ITVJ?
CAMA-1 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUDJR|UxRTBwMECxN|Eh|ryP Mn7VV2FPT0WU
SCC-9 NVTHdVA1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXfJR|UxRTBwMECxN|Ih|ryP M3fYUXNCVkeHUh?=
SAS MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWfHTohJUUN3ME2wMlAxOTN2IN88US=> MVjTRW5ITVJ?
KYSE-180 NH22PFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVjwTIdrUUN3ME2wMlAxOTN3IN88US=> MXXTRW5ITVJ?
EW-16 M3jnUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2PVUmlEPTB;MD6wNFE{PSEQvF2= MkO3V2FPT0WU
HD-MY-Z Mo[5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoXaTWM2OD1yLkCwNVQyKM7:TR?= MV3TRW5ITVJ?
KYSE-450 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTBwMECxOFMh|ryP MmnjV2FPT0WU
LCLC-97TM1 M3rYeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVvJR|UxRTBwMECxOFQh|ryP NIjUeJRUSU6JRWK=
KS-1 MkPTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlr4TWM2OD1yLkCwNVQ1KM7:TR?= M2HoeHNCVkeHUh?=
TI-73 MlnES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYrLbmpiUUN3ME2wMlAxOTR2IN88US=> NGLjc2lUSU6JRWK=
A427 Ml\tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2q5U2lEPTB;MD6wNFE1QCEQvF2= NInq[JlUSU6JRWK=
LB831-BLC M1vxVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mor4TWM2OD1yLkCwNVQ5KM7:TR?= M{T0SXNCVkeHUh?=
MG-63 NHO1SWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoLQTWM2OD1yLkCwNVUyKM7:TR?= M4frNnNCVkeHUh?=
PANC-03-27 Mm\BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVnHfG02UUN3ME2wMlAxOTV2IN88US=> NWi4c5RVW0GQR1XS
23132-87 NXLvR2xGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGfZb5hKSzVyPUCuNFAyPTVizszN NYPYRWU{W0GQR1XS
ES4 MmPxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGXuSnFKSzVyPUCuNFAyPTVizszN MYjTRW5ITVJ?
KP-4 MkTmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTBwMECxOVYh|ryP NWrGSZRkW0GQR1XS
NCI-H1703 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXrqe2g3UUN3ME2wMlAxOTV5IN88US=> Mn3RV2FPT0WU
MCF7 MkPOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M17qUmlEPTB;MD6wNFE3OSEQvF2= NVexO5ZjW0GQR1XS
A172 M3Xmfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXPTcmpwUUN3ME2wMlAxOTZ|IN88US=> MUPTRW5ITVJ?
CAL-39 NV\lOJlsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1\OdmlEPTB;MD6wNFE3OyEQvF2= NYLOTFJEW0GQR1XS
Saos-2 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYf3[lN1UUN3ME2wMlAxOTZ6IN88US=> MlPNV2FPT0WU
EW-11 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHH1[plKSzVyPUCuNFAyPjlizszN M2jvWXNCVkeHUh?=
D-336MG NHPTfnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTBwMECxOlkh|ryP M3\VTnNCVkeHUh?=
SW13 NVnu[pAxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnjVFB[UUN3ME2wMlAxOTZ7IN88US=> NFywcGtUSU6JRWK=
ME-180 MlPnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1LTeWlEPTB;MD6wNFE3QSEQvF2= MXjTRW5ITVJ?
SK-MEL-2 M4WyUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTBwMECxO{DPxE1? MnjpV2FPT0WU
697 NWS2UIhCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoXkTWM2OD1yLkCwNVczKM7:TR?= NHXFW3lUSU6JRWK=
D-247MG NXvrN|JET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF7mbYJKSzVyPUCuNFAyPzNizszN MmntV2FPT0WU
EoL-1-cell M3rEOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3HWPWlEPTB;MD6wNFE4OyEQvF2= NEPxdXZUSU6JRWK=
MV-4-11 NHfIfJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTBwMECxO|Qh|ryP NIDFeHJUSU6JRWK=
U-2-OS M{HpWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmPQTWM2OD1yLkCwNVc2KM7:TR?= MkS5V2FPT0WU
NCI-H526 NUXE[HAzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1PTbGlEPTB;MD6wNFE4PiEQvF2= MVPTRW5ITVJ?
SK-NEP-1 Mmn2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnTkTWM2OD1yLkCwNVc3KM7:TR?= NVn0WIZrW0GQR1XS
DB NITae2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGfpSlZKSzVyPUCuNFAyPzhizszN MoPzV2FPT0WU
GCT NVvyZoZnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1f4T2lEPTB;MD6wNFE5KM7:TR?= MV\TRW5ITVJ?
HCT-116 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEHyVo5KSzVyPUCuNFAyQDFizszN NUfXcIQ3W0GQR1XS
AU565 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlfJTWM2OD1yLkCwNVgyKM7:TR?= NYTITGNOW0GQR1XS
KALS-1 MnnPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlraTWM2OD1yLkCwNVgyKM7:TR?= M{[1UnNCVkeHUh?=
C2BBe1 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\lOmlEPTB;MD6wNFE5OiEQvF2= NVG5PYlNW0GQR1XS
Becker NUL3TI4yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkfqTWM2OD1yLkCwNVg{KM7:TR?= NGnZUZVUSU6JRWK=
647-V MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1viZWlEPTB;MD6wNFE5PCEQvF2= MWHTRW5ITVJ?
NCI-H2122 NITofmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXz5epZtUUN3ME2wMlAxOTh2IN88US=> NXjzfY1TW0GQR1XS
SBC-5 NWrxdGg6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH3IXJVKSzVyPUCuNFAyQDdizszN NV\v[Zd5W0GQR1XS
NB17 NYX0UlhbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{K4O2lEPTB;MD6wNFE5QSEQvF2= NETEWXlUSU6JRWK=
MHH-PREB-1 M{LhSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1Thc2lEPTB;MD6wNFE5QSEQvF2= MXvTRW5ITVJ?
M14 NHXiSotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmXzTWM2OD1yLkCwNVkyKM7:TR?= MVXTRW5ITVJ?
NCI-H1048 NVPuS3A5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3HWUGlEPTB;MD6wNFE6OiEQvF2= NGfI[IxUSU6JRWK=
CTB-1 NF;CcXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zVWmlEPTB;MD6wNFE6OiEQvF2= M1riSnNCVkeHUh?=
SK-PN-DW Mo\FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTBwMECxPVQh|ryP NF7DUWZUSU6JRWK=
H4 M{XtZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1f3ZmlEPTB;MD6wNFE6PiEQvF2= MmfjV2FPT0WU
NCI-SNU-1 NHeze4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2LGe2lEPTB;MD6wNFE6PyEQvF2= MXzTRW5ITVJ?
M059J NIjXe4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{DsWWlEPTB;MD6wNFE6QCEQvF2= MVnTRW5ITVJ?
OVCAR-5 NGXiNpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUXBPIp{UUN3ME2wMlAxOTl7IN88US=> Mn7pV2FPT0WU
SK-MEL-28 Mlj3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX\QXGlIUUN3ME2wMlAxOjB|IN88US=> NVrIdnE6W0GQR1XS
PC-14 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{jZeWlEPTB;MD6wNFIxQSEQvF2= M2DrZnNCVkeHUh?=
OVCAR-8 NXjYWXExT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2TLS2lEPTB;MD6wNFIyOiEQvF2= MkLpV2FPT0WU
BB49-HNC Mni0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHrIUlFKSzVyPUCuNFAzOTJizszN NUPBPYQ1W0GQR1XS
EFM-19 MkL2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHrQVnBKSzVyPUCuNFAzOTVizszN MWfTRW5ITVJ?
BHY NHv5RZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGHKN4NKSzVyPUCuNFAzOTZizszN MkfYV2FPT0WU
SW756 MlPVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVX5Oo02UUN3ME2wMlAxOjF4IN88US=> MmDYV2FPT0WU
TE-1 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVW2PFh5UUN3ME2wMlAxOjF4IN88US=> NV36Z|F3W0GQR1XS
NCI-H2452 MmXLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEPxWG1KSzVyPUCuNFAzOTZizszN M3HT[3NCVkeHUh?=
NCI-H1581 NIrwXWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnvRTWM2OD1yLkCwNlE4KM7:TR?= MV3TRW5ITVJ?
COR-L23 NXzqWnhVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVXu[|MxUUN3ME2wMlAxOjJizszN MnH1V2FPT0WU
RXF393 NHKxWlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M122XmlEPTB;MD6wNFIzOiEQvF2= NVT5OnVYW0GQR1XS
BFTC-909 NYCyNIlPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk\6TWM2OD1yLkCwNlI2KM7:TR?= NVfvXWl7W0GQR1XS
IST-MEL1 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkG1TWM2OD1yLkCwNlI2KM7:TR?= NUf0eGptW0GQR1XS
NCI-H650 Ml;QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTBwMECyNlUh|ryP M1rG[HNCVkeHUh?=
SK-UT-1 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVLqeGd[UUN3ME2wMlAxOjJ4IN88US=> NEP3U5dUSU6JRWK=
GOTO Ml7FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3uzdmlEPTB;MD6wNFIzPyEQvF2= M2H6RnNCVkeHUh?=
TYK-nu M1ezOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1Lu[2lEPTB;MD6wNFI{OiEQvF2= MYPTRW5ITVJ?
JVM-3 MnX3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXzzUnV2UUN3ME2wMlAxOjN|IN88US=> NULmcoZsW0GQR1XS
SK-MES-1 M1zGVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3HTOmlEPTB;MD6wNFI{OyEQvF2= MlH6V2FPT0WU
SK-HEP-1 NWS1[IlyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTBwMECyN|Qh|ryP MXHTRW5ITVJ?
J-RT3-T3-5 NID4eFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX;JR|UxRTBwMECyN|Uh|ryP NFHmUItUSU6JRWK=
A673 NHjZOmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTBwMECyN|Uh|ryP NXvjUotqW0GQR1XS
NCI-H446 NF63TlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV\NTZZ5UUN3ME2wMlAxOjR|IN88US=> NH[yN5JUSU6JRWK=
RPMI-2650 M1HlS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MofaTWM2OD1yLkCwNlQ3KM7:TR?= NGfOUVBUSU6JRWK=
HCE-4 MkjMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTBwMECyOFch|ryP MoLoV2FPT0WU
KGN MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIL2[4ZKSzVyPUCuNFAzPDdizszN Mnf0V2FPT0WU
U251 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGrF[2pKSzVyPUCuNFAzPSEQvF2= M2CyW3NCVkeHUh?=
BxPC-3 NGfmVo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYjV[nZyUUN3ME2wMlAxOjVzIN88US=> M4PZd3NCVkeHUh?=
VMRC-RCZ MmnPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWPJR|UxRTBwMECyOVIh|ryP MUfTRW5ITVJ?
TE-10 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1TCeGlEPTB;MD6wNFI2PCEQvF2= NYf1R4N2W0GQR1XS
OC-314 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWe3U3R4UUN3ME2wMlAxOjV4IN88US=> MlfmV2FPT0WU
NCI-H1437 NV;0bJhUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYTINVV[UUN3ME2wMlAxOjZizszN M1TkPHNCVkeHUh?=
SNU-387 Mkn6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlm0TWM2OD1yLkCwNlYyKM7:TR?= NU\Oc|RiW0GQR1XS
A388 NUDrVpBVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn3vTWM2OD1yLkCwNlY2KM7:TR?= NFi4Z5dUSU6JRWK=
C-33-A MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTBwMECyOlYh|ryP NYnHcnlDW0GQR1XS
CAL-51 MmLMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;BTWM2OD1yLkCwNlcyKM7:TR?= NGmy[VRUSU6JRWK=
Hs-578-T NUXFd5Z3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\iSmlEPTB;MD6wNFI4OiEQvF2= M{XyUnNCVkeHUh?=
MDA-MB-415 NIXzV5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmL0TWM2OD1yLkCwNlc1KM7:TR?= NV3YO3lnW0GQR1XS
SW1417 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\DTWM2OD1yLkCwNlc3KM7:TR?= MUjTRW5ITVJ?
HCC70 NH:2WWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4nFZmlEPTB;MD6wNFI4PyEQvF2= M3jTOHNCVkeHUh?=
ES3 NUDkN3dtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVHmXo91UUN3ME2wMlAxOjd5IN88US=> M1LVfXNCVkeHUh?=
KYSE-270 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVrHb4dkUUN3ME2wMlAxOjd6IN88US=> NYjlZZkxW0GQR1XS
HT-29 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1u2NWlEPTB;MD6wNFI5KM7:TR?= M32wO3NCVkeHUh?=
MDA-MB-361 NUDkUWlkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYjRUY95UUN3ME2wMlAxOjhzIN88US=> MWjTRW5ITVJ?
RPMI-8866 MoKyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NID2[VRKSzVyPUCuNFAzQDFizszN MXvTRW5ITVJ?
JEG-3 M4jxXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3i2[2lEPTB;MD6wNFI5OiEQvF2= M4faO3NCVkeHUh?=
HT-3 NVHDZXpvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGHpSZNKSzVyPUCuNFAzQDJizszN MlHOV2FPT0WU
HTC-C3 M4nkRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NILjdYJKSzVyPUCuNFAzQDVizszN NX7q[2pHW0GQR1XS
NCI-H209 MkfmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4XTV2lEPTB;MD6wNFI5PiEQvF2= NWfkUpNDW0GQR1XS
SKG-IIIa NFHPUFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;GTWM2OD1yLkCwNlg3KM7:TR?= M2LFc3NCVkeHUh?=
SW962 NWTYfmsxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEHDcolKSzVyPUCuNFAzQTNizszN Mo[0V2FPT0WU
LCLC-103H NU\D[o97T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPqTWM2OD1yLkCwNlk{KM7:TR?= M2CyXnNCVkeHUh?=
DOK NV\ZSldjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHMTWM2OD1yLkCwNlk1KM7:TR?= NVjEe2lkW0GQR1XS
SW1088 M1mzUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3vBTGlEPTB;MD6wNFI6PSEQvF2= M3;1cHNCVkeHUh?=
GP5d M4jL[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHSxe3pKSzVyPUCuNFAzQTZizszN MkLrV2FPT0WU
EW-1 M{S3dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1vXSGlEPTB;MD6wNFI6QCEQvF2= MWHTRW5ITVJ?
CP66-MEL NFTkfm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XIfWlEPTB;MD6wNFMh|ryP NYfEZXBbW0GQR1XS
DEL NVGw[np7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV;iSZJXUUN3ME2wMlAxOzBzIN88US=> NXn4O4wxW0GQR1XS
DU-4475 M4jo[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHyyOmtKSzVyPUCuNFA{ODJizszN NYTzb2ZLW0GQR1XS
HEC-1 M4jKdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHS2SItKSzVyPUCuNFA{ODNizszN MmfWV2FPT0WU
U031 Mm\YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4e4N2lEPTB;MD6wNFMxPyEQvF2= NXK5UpVzW0GQR1XS
BB65-RCC NXzFUFJRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHTzW5lKSzVyPUCuNFA{ODhizszN Ml;GV2FPT0WU
NUGC-3 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1vGPGlEPTB;MD6wNFMxQCEQvF2= M2WyNnNCVkeHUh?=
IST-SL1 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFf3W5pKSzVyPUCuNFA{OTJizszN M1nB[XNCVkeHUh?=
LS-411N MlO3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF7Rd2xKSzVyPUCuNFA{OTRizszN MnzQV2FPT0WU
22RV1 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYrKWGdMUUN3ME2wMlAxOzF3IN88US=> NFfMXG5USU6JRWK=
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ONS-76 NVfFUHVmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\VTWM2OD1yLkCwN|IzKM7:TR?= MonnV2FPT0WU
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MC116 NXjkSZRtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3zHS2lEPTB;MD6yPFMxQSEQvF2= MoT5V2FPT0WU
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HEL M3P5PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTBwM{KyOEDPxE1? M4rXfXNCVkeHUh?=
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C32 NEnp[2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\aOol3UUN3ME2wMlc1OTF{IN88US=> MlfRV2FPT0WU
K-562 M1e0W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUHE[XlzUUN3ME2wMlc4ODJ2IN88US=> M4D0TnNCVkeHUh?=
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RCC10RGB NFzFS5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2f1TmlEPTB;MD63PVE5OyEQvF2= M{nhRXNCVkeHUh?=
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NCI-H1993 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVnuXFJEUUN3ME2xMlE6Ojh7IN88US=> NGHFRohUSU6JRWK=
SK-OV-3 NWXKSmVoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYfTOlFHUUN3ME2xMlIzODh7IN88US=> MWjTRW5ITVJ?

... Click to View More Cell Line Experimental Data

In vivo Docetaxel (33 mg/kg/dose, given i.v. every 4 days for 3 injections) results in a tumor growth delay of 19.3 days in M2OL2 colon xenografts. Docetaxel also shows great antitumor activities in MX-1, SK-MEL-2, LX-1 and OVCAR-3 xenografts. Docetaxel inhibits the angiogenic response to fibroblast growth factor 2 with IC 50 of 5.4 mg/kg when injected twice weekly over a 14-day period, and angiogenesis is completely blocked in mice that receives 10 mg/kg Docetaxel. Docetaxel has selectivity for endothelial cell migration and/or microvessel formation because infiltration of inflammatory cells into the Matrigel plug is much less sensitive to inhibition by Docetaxel. [7]

Protocol

Cell Research:[5]
+ Expand
  • Cell lines: Human gastric cancer cell lines MKN-28
  • Concentrations: 6 nM
  • Incubation Time: 3 days
  • Method: 2000 cells in 180 μL of medium are seeded in a 96-well plate, and 20 μL of drug solution is simultaneously added in triplicate to each well. The plate is incubated for 3 days at 37°C in a humidified atmosphere of 5% CO2. On day 3, 25 μL of MTT reagent is added to each well. After 4 h of incubation, the medium is removed by aspiration. 0.2 mL of dimethylsulphoxide (DMSO) is added to each well and thoroughly mixed by using a mechanical plate mixer to dissolve the resulting MTT-formazan crystals. Absorbance at 540 nm (OD) is measured by a reader.
    (Only for Reference)
Animal Research:[6]
+ Expand
  • Animal Models: Human colon carcinomas xenografts CX-1
  • Formulation: 50 mg/mL stock solution in ethanol by adding an equal volume of polysorbate 80 and diluting with 5% dextrose in water to the final volume
  • Dosages: 33 mg/kg
  • Administration: i.v. every 4 days for 3 injections
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (123.78 mM)
Ethanol 53 mg/mL warmed (65.6 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order:
5% DMSO+30% PEG 300+5% Tween 80+ddH2O
2mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 807.88
Formula

C43H53NO14

CAS No. 114977-28-5
Storage powder
Synonyms RP56976, NSC 628503

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02124902 Recruiting Triple Negative Breast Neoplasms Washington University School of Medicine July 7, 2014 Phase 2
NCT01683994 Recruiting Prostatic Neoplasms National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) September 6, 2012 Phase 1|Phase 2
NCT02649855 Recruiting Prostate Cancer|Prostate Neoplasms|Neoplasms, Prostatic National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) January 4, 2016 Phase 2
NCT03041181 Recruiting Non-Squamous Non-Small Cell Lung Cancer (NSCLC)|Adenocarcinoma of the Lung|Lung Cancer Nasser Hanna, M.D.|Hoosier Cancer Research Network|Bristol-Myers Squibb January 27, 2017 Phase 2
NCT00251433 Active, not recruiting Neoplasms, Breast Novartis Pharmaceuticals|Novartis September 26, 2005 Phase 1
NCT01907529 Not yet recruiting Stage III Breast Cancer Hebei Medical University Fourth Hospital August 2018 Phase 2|Phase 3

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID