Docetaxel

Catalog No.S1148 Synonyms: RP56976, NSC 628503

Docetaxel Chemical Structure

Molecular Weight(MW): 807.88

Docetaxel, an analog of paclitaxel, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules.

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In DMSO USD 91 In stock
USD 70 In stock
USD 270 In stock
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5 Customer Reviews

  • Viability of cells after exposure to 0, 10, or 10,000 nM docetaxel, assessed by calcein-AM staining (green, left panels) and ethidium homodimer-1 (red, middle panels).

    Mol Pharmaceutics, 2014, 11: 2040−50. Docetaxel purchased from Selleck.

    TNBC and non-TNBC cells were treated for 6 d with the specified concentrations of docetaxel (doc) alone, TTK inhibitor (TTKi) alone or the combinations. The survival of cells was measured using the MTS/MTA assay. ***P<0.001 comparing the combination with single agents and with non-TNBC cell lines.

    Oncogenesis, 2014, 3: e100 . Docetaxel purchased from Selleck.

  • J Transl Med 2013 0.6. Docetaxel purchased from Selleck.

    J Transl Med 2013 0.6. Docetaxel purchased from Selleck.

  • Cell cycle study of percent cell populations in various phases after treatment with vehicle, HCI-2509 in increasing concentrations and docetaxel alone and in combination with HCI-2509 using (a) PC3 cells. Student's unpaired t-tests, using GraphPad Prism software, were used to calculate two-tailed P-values for each experiment to determine statistical significance between untreated and treated samples. The statistically significant P-values are labeled in each figure with an asterisk. (Replicated two more times, representative graph shown).

    Prostate Cancer Prostatic Dis, 2016, 19(4):349-357. Docetaxel purchased from Selleck.

Purity & Quality Control

Choose Selective Microtubule Associated Inhibitors

Biological Activity

Description Docetaxel, an analog of paclitaxel, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules.
Targets
Microtubules [1]
(Cell-free assay)
In vitro

Docetaxel is a cytotoxic agent, especially for proliferating cells, which is related to its ability to promote the formation of microtubule bundles and induce sustained mitotic arrest, followed by apoptosis of mitotically arrested cells or permanent mitotic block. Docetaxel suppresses microtubule dynamic instability as well as tread-milling, resulting in the failure of chromosomes to segregate to the daughter cells, which in turn triggers premature exit from mitosis rather than a block at this phase of the cell cycle. [2] Docetaxel inhibits the clonogenic survival of Human cancer cell Hs746T (stomach), AGS (stomach), HeLa (cervix), CaSki (cervix), BxPC3 (pancreas), Capan-1 (pancreas) with IC50 of 1 nM, 1 nM, 0.3 nM, 0.3 nM, 0.3 nM and 0.3 nM respectively. [4] Docetaxel inhibits endothelial cell migration that does not affects microtubule gross morphology or inhibit cell proliferation, although they does produce more subtle effects on microtubule dynamics. Docetaxel inhibits HUVEC migration with an observed IC50 of 1 pM. HUVEC chemotaxis stimulated by either of two angiogenic factors, thymidine phosphorylase or VEGF, is inhibited by Docetaxel with IC 50 of 10 pM and is ablated at 1 nM. [7] Docetaxel induces human monocytes, but not RAW 264.7 murine macrophages, Prostaglandin H Synthase-2m (PGHS-2) expression. [8]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HSC-3 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGTaOoJKSzVyPUCuNFAxOTN{IN88US=> NIr1NlRUSU6JRWK=
5637 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEnOfZFKSzVyPUCuNFAxOTR|IN88US=> MlLIV2FPT0WU
HT-144 M{jr[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{XrU2lEPTB;MD6wNFAyPTdizszN NXW4ZoV5W0GQR1XS
NCI-H292 NEHMdIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml3tTWM2OD1yLkCwNFE2QSEQvF2= NXf2enJXW0GQR1XS
HCE-T M4fHZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUKxfGtuUUN3ME2wMlAxODF4MjFOwG0> M2HweXNCVkeHUh?=
ESS-1 NHntXIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlnWTWM2OD1yLkCwNFE4QSEQvF2= M2D2e3NCVkeHUh?=
D-566MG M4nzcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4GyPWlEPTB;MD6wNFAyQDJizszN MUnTRW5ITVJ?
CAL-62 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEm4PGZKSzVyPUCuNFAxOTh3IN88US=> MofxV2FPT0WU
GT3TKB M{S4fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFfLT2hKSzVyPUCuNFAxOjN{IN88US=> NUHPRpVFW0GQR1XS
HSC-4 NXzRZWxuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnnvTWM2OD1yLkCwNFI{QSEQvF2= NGq3UGRUSU6JRWK=
KOSC-2 MlP2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3nrWmlEPTB;MD6wNFAzPTVizszN Mo\EV2FPT0WU
NB14 MoT0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlzoTWM2OD1yLkCwNFI3KM7:TR?= MYPTRW5ITVJ?
ES8 M3G4Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIPsZnZKSzVyPUCuNFAxOjZizszN NWHYeoNHW0GQR1XS
BFTC-905 NUPVcIdtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4TYNWlEPTB;MD6wNFAzPjhizszN NVz1cVBXW0GQR1XS
A498 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2XMbmlEPTB;MD6wNFAzPzhizszN M2K4dHNCVkeHUh?=
HO-1-N-1 MnPpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWjKeIZ6UUN3ME2wMlAxODJ6MTFOwG0> NWLGZmc5W0GQR1XS
SF539 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX7pb5NwUUN3ME2wMlAxODNyMjFOwG0> M{GxfnNCVkeHUh?=
HuO-3N1 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVX1TJhZUUN3ME2wMlAxODNyMjFOwG0> NW\WTpp4W0GQR1XS
NCI-H510A NYnKcWZbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTBwMECwN|M3KM7:TR?= MXrTRW5ITVJ?
CAL-27 M13wfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYqyRYxTUUN3ME2wMlAxODN|OTFOwG0> NUPFZotWW0GQR1XS
TE-8 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4frdGlEPTB;MD6wNFA{PjZizszN MYDTRW5ITVJ?
VA-ES-BJ MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTBwMECwN|c2KM7:TR?= M1LjOHNCVkeHUh?=
RH-1 NXH2WG8yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHKxbYtKSzVyPUCuNFAxOzh4IN88US=> MYDTRW5ITVJ?
COLO-800 NUSxNY9WT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUjJR|UxRTBwMECwN|g5KM7:TR?= NUPLc4F6W0GQR1XS
ES7 NIfhfIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml7YTWM2OD1yLkCwNFM5QSEQvF2= MlXVV2FPT0WU
GAMG NHL0VHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkW3TWM2OD1yLkCwNFQyPiEQvF2= MYTTRW5ITVJ?
Ca9-22 MoDlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDrTWM2OD1yLkCwNFQzOyEQvF2= NYe3fZdHW0GQR1XS
SBC-1 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mkn5TWM2OD1yLkCwNFQ{KM7:TR?= MYjTRW5ITVJ?
RPMI-7951 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHW1ZpdKSzVyPUCuNFAxPDR6IN88US=> NX:3SG5zW0GQR1XS
SW1710 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIPBeJRKSzVyPUCuNFAxPDZ4IN88US=> MnvMV2FPT0WU
HGC-27 NWLZSmI5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlXTTWM2OD1yLkCwNFQ4OSEQvF2= M17vc3NCVkeHUh?=
MC-IXC MoPQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlfNTWM2OD1yLkCwNFQ4QSEQvF2= NVflXGxUW0GQR1XS
FTC-133 MnnpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Moj5TWM2OD1yLkCwNFQ5QSEQvF2= M2PH[XNCVkeHUh?=
HT-1080 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUfHZph{UUN3ME2wMlAxODVyMTFOwG0> NUfYfWF6W0GQR1XS
NMC-G1 M2O4S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4\jfmlEPTB;MD6wNFA2OTdizszN MmHFV2FPT0WU
GI-1 NUDD[ZZtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUjl[I1oUUN3ME2wMlAxODV{ODFOwG0> MX;TRW5ITVJ?
CGTH-W-1 NV\idY1RT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTBwMECwOVQzKM7:TR?= M37ZdnNCVkeHUh?=
A2058 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF;zbFRKSzVyPUCuNFAxPTR2IN88US=> MXzTRW5ITVJ?
ETK-1 NXzTbm4{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfCPJVKSzVyPUCuNFAxPTV6IN88US=> M2fwfXNCVkeHUh?=
NEC8 M3;1N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTBwMECwOVYyKM7:TR?= M1;1S3NCVkeHUh?=
TE-11 NYW5PVVyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEfXPVNKSzVyPUCuNFAxPTZ7IN88US=> NUO5eW5IW0GQR1XS
NCI-H720 NGP0XXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlPXTWM2OD1yLkCwNFU5KM7:TR?= NH;CNYpUSU6JRWK=
PSN1 NYr6RWpjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHu5fIJKSzVyPUCuNFAxPThzIN88US=> M{\TU3NCVkeHUh?=
SW780 MoXPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXfDSHhXUUN3ME2wMlAxODV6NzFOwG0> NVnJTpoyW0GQR1XS
8-MG-BA Mn7mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTBwMECwOVg6KM7:TR?= MY\TRW5ITVJ?
EC-GI-10 NETlUHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXPW[4Q1UUN3ME2wMlAxODV7MjFOwG0> NHTjS4tUSU6JRWK=
SJSA-1 NHLkZ3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTBwMECwOlE2KM7:TR?= NV;MdpFxW0GQR1XS
639-V MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTBwMECwOlQ4KM7:TR?= NFPVTFFUSU6JRWK=
PFSK-1 NIn5PYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTBwMECwOlU4KM7:TR?= Mn\YV2FPT0WU
DMS-273 MnjZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mme4TWM2OD1yLkCwNFY4PCEQvF2= MnL0V2FPT0WU
TE-9 MkjXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF3DcFNKSzVyPUCuNFAxPjd4IN88US=> MmnHV2FPT0WU
SCC-25 NHXmeIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTBwMECwOlgh|ryP MnXFV2FPT0WU
PA-1 NFfpNZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlnsTWM2OD1yLkCwNFY5PyEQvF2= NXzHR|FsW0GQR1XS
MHH-ES-1 NUXZVlNxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlyzTWM2OD1yLkCwNFch|ryP MYHTRW5ITVJ?
Daoy NW\zToVET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn;zTWM2OD1yLkCwNFch|ryP NUPuUZZsW0GQR1XS
G-402 NHrQW2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3a[mRKUUN3ME2wMlAxODdyNjFOwG0> NWCyS4pPW0GQR1XS
YKG-1 M2nqNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIHqNoZKSzVyPUCuNFAxPzB5IN88US=> MXrTRW5ITVJ?
Ca-Ski M4fheGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTBwMECwO|I5KM7:TR?= M3fRVnNCVkeHUh?=
CHP-212 NG\KSmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYXJR|UxRTBwMECwO|Mh|ryP NXPy[Xp{W0GQR1XS
SCC-4 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXTqWIlFUUN3ME2wMlAxODd|OTFOwG0> MmPaV2FPT0WU
EW-3 M3zvRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYnhe5p[UUN3ME2wMlAxODd2NTFOwG0> M3;LWnNCVkeHUh?=
P12-ICHIKAWA NX;xVI1KT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{XHO2lEPTB;MD6wNFA4PDVizszN MXnTRW5ITVJ?
HSC-2 M4TUVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYPqfHdJUUN3ME2wMlAxODd3NTFOwG0> MkDDV2FPT0WU
HN NUPiVZRZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NULYNI9kUUN3ME2wMlAxODd3ODFOwG0> NH;SPFBUSU6JRWK=
LXF-289 NWqyd25nT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGnCXVFKSzVyPUCuNFAxPzV6IN88US=> NWnLboVZW0GQR1XS
ES1 NUe3dmY{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\JT4lbUUN3ME2wMlAxODd5IN88US=> MlzEV2FPT0WU
NTERA-S-cl-D1 NUPWTVlTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mof3TWM2OD1yLkCwNFc4OyEQvF2= NX7iVJpDW0GQR1XS
K5 Mn;pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTBwMECwO|c5KM7:TR?= M16wUnNCVkeHUh?=
HOS MkfWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4PEU2lEPTB;MD6wNFA4QDJizszN NYTDeJNzW0GQR1XS
YH-13 MoPMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3GxfmlEPTB;MD6wNFA4QTFizszN NXW3XXh3W0GQR1XS
SW954 M4LseGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlmyTWM2OD1yLkCwNFgzOyEQvF2= M1LYfnNCVkeHUh?=
KYSE-510 M{n6VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIrnZpNKSzVyPUCuNFAxQDRizszN NGfMOZdUSU6JRWK=
8505C NVPu[pJlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NInYWo5KSzVyPUCuNFAxQDV2IN88US=> MV\TRW5ITVJ?
A549 MkLjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIfVPFZKSzVyPUCuNFAxQDh{IN88US=> MUXTRW5ITVJ?
Detroit562 NF\ZUZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTBwMECwPVAzKM7:TR?= NHPtUG1USU6JRWK=
ES5 NHzD[VJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXPNZYJLUUN3ME2wMlAxODlzIN88US=> MWXTRW5ITVJ?
KYSE-140 M1G4[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3qWZBPUUN3ME2wMlAxODl|MzFOwG0> NIi4fohUSU6JRWK=
GMS-10 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlzoTWM2OD1yLkCwNFk1OSEQvF2= NYrudJdIW0GQR1XS
D-263MG NEDD[21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV\JR|UxRTBwMECwPVQ4KM7:TR?= NEjacldUSU6JRWK=
BCPAP M1H2N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn7ETWM2OD1yLkCwNFk1PyEQvF2= NELIe2lUSU6JRWK=
CHL-1 NFSwcIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTBwMECwPVU5KM7:TR?= MXHTRW5ITVJ?
RKO M{ezVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHXUT3hKSzVyPUCuNFAxQTh7IN88US=> NHexWZpUSU6JRWK=
SW48 MlLDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHkTWM2OD1yLkCwNVAyKM7:TR?= NWDPcJA4W0GQR1XS
BPH-1 NHPUN3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHXkNWVKSzVyPUCuNFAyODJizszN NIjZVZBUSU6JRWK=
EFO-27 M{LOfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTBwMECxNFIh|ryP NIfvTI1USU6JRWK=
CAL-33 MkPSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{SzPGlEPTB;MD6wNFExPCEQvF2= M{\XNHNCVkeHUh?=
NCI-H1792 NVrHOnRRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUH2V5c5UUN3ME2wMlAxOTB2IN88US=> MUfTRW5ITVJ?
BB30-HNC Mk\sS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYfpNFVHUUN3ME2wMlAxOTB3IN88US=> MVvTRW5ITVJ?
VM-CUB-1 NX3nZYQyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{fzXGlEPTB;MD6wNFExPSEQvF2= NVHKXZEyW0GQR1XS
TE-5 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmXXTWM2OD1yLkCwNVA3KM7:TR?= NHrXXHZUSU6JRWK=
NB13 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHHXfo1KSzVyPUCuNFAyODdizszN MlzHV2FPT0WU
NBsusSR NXTjbFU6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MW\JR|UxRTBwMECxNUDPxE1? MWfTRW5ITVJ?
LNCaP-Clone-FGC MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkH1TWM2OD1yLkCwNVEh|ryP M3vaOHNCVkeHUh?=
EPLC-272H MkPZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MortTWM2OD1yLkCwNVEyKM7:TR?= NVmydJBZW0GQR1XS
KNS-62 Mlm5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3PiR2lEPTB;MD6wNFEyOiEQvF2= MXrTRW5ITVJ?
RERF-LC-MS Ml3SS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NITTNXhKSzVyPUCuNFAyOTNizszN NYHrUHBoW0GQR1XS
LOXIMVI NWHrZms6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHlTWM2OD1yLkCwNVE3KM7:TR?= NUXMN2I4W0GQR1XS
KINGS-1 MnrOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1jTfWlEPTB;MD6wNFEyPyEQvF2= NGnmfoFUSU6JRWK=
T98G MnrES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Moe3TWM2OD1yLkCwNVE4KM7:TR?= MW\TRW5ITVJ?
HCC1806 Mnq1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXrRc3l[UUN3ME2wMlAxOTF6IN88US=> MkLwV2FPT0WU
MZ1-PC NFfw[VZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnjjTWM2OD1yLkCwNVE5KM7:TR?= M3vIZXNCVkeHUh?=
RT-112 NFTIXVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7JS5FKSzVyPUCuNFAyOTlizszN M2eyfXNCVkeHUh?=
LK-2 NYnBdGhoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmC4TWM2OD1yLkCwNVIyKM7:TR?= MX3TRW5ITVJ?
A375 M13keGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\XNnRKSzVyPUCuNFAyOjFizszN M1zEcHNCVkeHUh?=
SF268 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTBwMECxNlEh|ryP M3fHfXNCVkeHUh?=
H9 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlzQTWM2OD1yLkCwNVI1KM7:TR?= MXfTRW5ITVJ?
KYSE-410 NH3ZTodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV[4Z|d6UUN3ME2wMlAxOTJ2IN88US=> MYjTRW5ITVJ?
G-401 MmPCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4n2OmlEPTB;MD6wNFEzPyEQvF2= M1;VcXNCVkeHUh?=
SW982 NWTUXHJ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF7QcHlKSzVyPUCuNFAyOjdizszN MYHTRW5ITVJ?
D-423MG M4DSeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVvJR|UxRTBwMECxN{DPxE1? M3LzVHNCVkeHUh?=
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KYSE-180 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mmj1TWM2OD1yLkCwNVM2KM7:TR?= NYLnOWNsW0GQR1XS
EW-16 M{fxUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX;VcHN4UUN3ME2wMlAxOTN3IN88US=> M3G0XnNCVkeHUh?=
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LCLC-97TM1 M4\q[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoniTWM2OD1yLkCwNVQ1KM7:TR?= MojHV2FPT0WU
KS-1 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVj4UFZXUUN3ME2wMlAxOTR2IN88US=> NEexcIFUSU6JRWK=
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NCI-H1703 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTBwMECxOVch|ryP MXfTRW5ITVJ?
MCF7 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTBwMECxOlEh|ryP MW\TRW5ITVJ?
A172 NXvodpdST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXzyW3lvUUN3ME2wMlAxOTZ|IN88US=> Mof4V2FPT0WU
CAL-39 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3P3OGlEPTB;MD6wNFE3OyEQvF2= NWD3UYlQW0GQR1XS
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DB MkPYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MojGTWM2OD1yLkCwNVc5KM7:TR?= M2njOHNCVkeHUh?=
GCT M2HEd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnTKTWM2OD1yLkCwNVgh|ryP MmrrV2FPT0WU
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NCI-H2122 MnP3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkexTWM2OD1yLkCwNVg1KM7:TR?= NG\nNWFUSU6JRWK=
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MHH-PREB-1 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYrHVHlHUUN3ME2wMlAxOTh7IN88US=> MnLmV2FPT0WU
M14 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHfGbZRKSzVyPUCuNFAyQTFizszN MXjTRW5ITVJ?
NCI-H1048 NX\IUXpXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRTBwMECxPVIh|ryP NVm2U4JUW0GQR1XS
CTB-1 M3S4dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnrVTWM2OD1yLkCwNVkzKM7:TR?= MorYV2FPT0WU
SK-PN-DW MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnL0TWM2OD1yLkCwNVk1KM7:TR?= NV\EV3VVW0GQR1XS
H4 NIG0eo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTTVVNuUUN3ME2wMlAxOTl4IN88US=> M2n6W3NCVkeHUh?=
NCI-SNU-1 M1fuN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NELyUW5KSzVyPUCuNFAyQTdizszN NIXIW3FUSU6JRWK=
M059J NFjIdppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH;CcpdKSzVyPUCuNFAyQThizszN Mm\uV2FPT0WU
OVCAR-5 NHHlR25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHn6WIxKSzVyPUCuNFAyQTlizszN NW\jbXRIW0GQR1XS
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PC-14 M3vTN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUC2R4c2UUN3ME2wMlAxOjB7IN88US=> NUf3VJV5W0GQR1XS
OVCAR-8 NGjnXnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUnZWWpsUUN3ME2wMlAxOjF{IN88US=> M2jkeXNCVkeHUh?=
BB49-HNC MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnHZTWM2OD1yLkCwNlEzKM7:TR?= NVzKe2o2W0GQR1XS
EFM-19 M1TRSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTBwMECyNVUh|ryP M3\ZWHNCVkeHUh?=
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TE-1 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{nXO2lEPTB;MD6wNFIyPiEQvF2= MkPLV2FPT0WU
NCI-H2452 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTBwMECyNVYh|ryP NVHKVHNZW0GQR1XS
NCI-H1581 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWC3bXJ5UUN3ME2wMlAxOjF5IN88US=> MWfTRW5ITVJ?
COR-L23 M2\YVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1zQTWlEPTB;MD6wNFIzKM7:TR?= MkjWV2FPT0WU
RXF393 NUDBfGJOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\XTWM2OD1yLkCwNlIzKM7:TR?= NGfZZYtUSU6JRWK=
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NCI-H650 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4KzTmlEPTB;MD6wNFIzPSEQvF2= NYfLV21sW0GQR1XS
SK-UT-1 M3joZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmj2TWM2OD1yLkCwNlI3KM7:TR?= NFzhfVlUSU6JRWK=
GOTO NED6UpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTBwMECyNlch|ryP M4\PVXNCVkeHUh?=
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JVM-3 NHrDb2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYTQTIM5UUN3ME2wMlAxOjN|IN88US=> MYTTRW5ITVJ?
SK-MES-1 NH62PZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3LPfmlEPTB;MD6wNFI{OyEQvF2= NYTwe3NOW0GQR1XS
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A673 Mn;pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1PSRWlEPTB;MD6wNFI{PSEQvF2= MYTTRW5ITVJ?
NCI-H446 NUTiepRtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3PxcmlEPTB;MD6wNFI1OyEQvF2= NFTtOXZUSU6JRWK=
RPMI-2650 NHj6UHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYrjeHR{UUN3ME2wMlAxOjR4IN88US=> MVTTRW5ITVJ?
HCE-4 NVjrO5RQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXu0dXBVUUN3ME2wMlAxOjR5IN88US=> MX\TRW5ITVJ?
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BxPC-3 Mn;RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV3ZT5JZUUN3ME2wMlAxOjVzIN88US=> NEL5cnFUSU6JRWK=
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TE-10 M4D5S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTBwMECyOVQh|ryP MV;TRW5ITVJ?
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NCI-H1437 NXrse3hET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NInYRYtKSzVyPUCuNFAzPiEQvF2= MU\TRW5ITVJ?
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A388 Mn\hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUDDXZpGUUN3ME2wMlAxOjZ3IN88US=> MnvlV2FPT0WU
C-33-A MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX2zZ4FZUUN3ME2wMlAxOjZ4IN88US=> NXTFdWU2W0GQR1XS
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Hs-578-T NXjHTHlDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoDCTWM2OD1yLkCwNlczKM7:TR?= NXPhR3FYW0GQR1XS
MDA-MB-415 Mlf6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTBwMECyO|Qh|ryP NXX4eJJvW0GQR1XS
SW1417 NUnYVVZqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mly5TWM2OD1yLkCwNlc3KM7:TR?= NUPMdpRiW0GQR1XS
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KYSE-270 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX\D[YhqUUN3ME2wMlAxOjd6IN88US=> MXzTRW5ITVJ?
HT-29 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV3McphKUUN3ME2wMlAxOjhizszN NWn0cI5nW0GQR1XS
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RPMI-8866 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIPSSolKSzVyPUCuNFAzQDFizszN M{e5WXNCVkeHUh?=
JEG-3 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTBwMECyPFIh|ryP NEHN[FZUSU6JRWK=
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NCI-H209 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1n4S2lEPTB;MD6wNFI5PiEQvF2= M4PTbXNCVkeHUh?=
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SW962 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTBwMECyPVMh|ryP M{nPRnNCVkeHUh?=
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DOK MlvES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWG3RphVUUN3ME2wMlAxOjl2IN88US=> NWPIOItuW0GQR1XS
SW1088 MoDrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHzsd5BKSzVyPUCuNFAzQTVizszN MWHTRW5ITVJ?
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EW-1 M3S1NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\WW2N3UUN3ME2wMlAxOjl6IN88US=> NGnw[3FUSU6JRWK=
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DU-4475 NV\MT3A5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjaTWM2OD1yLkCwN|AzKM7:TR?= NXLPfnExW0GQR1XS
HEC-1 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFj3WG1KSzVyPUCuNFA{ODNizszN MXPTRW5ITVJ?
U031 M1HkbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3vjSmlEPTB;MD6wNFMxPyEQvF2= MlPRV2FPT0WU
BB65-RCC MlrhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTBwMECzNFgh|ryP MV3TRW5ITVJ?
NUGC-3 M{nYS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFrBb5VKSzVyPUCuNFA{ODhizszN NHLWSWtUSU6JRWK=
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LS-411N MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIf1fpVKSzVyPUCuNFA{OTRizszN M1OwbnNCVkeHUh?=
22RV1 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFjtWXdKSzVyPUCuNFA{OTVizszN NVHWTZpwW0GQR1XS
MKN28 NFzLc4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoLBTWM2OD1yLkCwN|E4KM7:TR?= NUfJPJBsW0GQR1XS
ONS-76 MnnmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVjJR|UxRTBwMECzNlIh|ryP NY\UUW9wW0GQR1XS
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AGS NITtSFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljzTWM2OD1yLkCwN|I5KM7:TR?= NVvsSYxbW0GQR1XS
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UACC-62 MlL2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHNTWM2OD1yLkCwN|Mh|ryP MXnTRW5ITVJ?
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A2780 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlPMTWM2OD1yLkCwN|M2KM7:TR?= NVzCOnNDW0GQR1XS
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NCI-H23 NGflVpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnvGTWM2OD1yLkCwN|Y1KM7:TR?= M1XTSXNCVkeHUh?=
NCI-H226 NVjRS2lDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2jZcGlEPTB;MD6wNFM3QCEQvF2= NXfJO4dzW0GQR1XS
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L-363 M2\RNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWrYWYdVUUN3ME2wMlAxOzd4IN88US=> MlnPV2FPT0WU
CAL-12T M2HOdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIXHcJRKSzVyPUCuNFA{PzZizszN MWHTRW5ITVJ?
BT-20 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\kTWM2OD1yLkCwN|c3KM7:TR?= M{fhPHNCVkeHUh?=
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BE-13 Ml23S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGq3ZlRKSzVyPUCuNFA{QTNizszN M2\xWnNCVkeHUh?=
NCI-H1395 M{W3TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml\UTWM2OD1yLkCwN|k3KM7:TR?= NXP4OHlWW0GQR1XS
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OVCAR-3 NHvNbYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWf2PXNnUUN3ME2wMlAxPDB5IN88US=> NWTyeno1W0GQR1XS
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D-502MG MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTBwMEC0NUDPxE1? NYXleo41W0GQR1XS
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LS-123 MnHKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWrKUWozUUN3ME2wMlAxPDJ3IN88US=> M2j3bnNCVkeHUh?=
SiHa M2XuU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnLtTWM2OD1yLkCwOFMh|ryP MonuV2FPT0WU
T47D MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTBwMEC0N|Eh|ryP MoXQV2FPT0WU
EW-24 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV3OXo5GUUN3ME2wMlAxPDN|IN88US=> M4riXXNCVkeHUh?=
CAL-120 M4PQbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkntTWM2OD1yLkCwOFM2KM7:TR?= NXXZZ|VDW0GQR1XS
JAR Mn:4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHjSeHRKSzVyPUCuNFA1OzdizszN NYD1bpg6W0GQR1XS
QIMR-WIL NUP3VXlVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3zQcGlEPTB;MD6wNFQ{QCEQvF2= NEDtZZlUSU6JRWK=
OCUB-M MlLJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{SxUWlEPTB;MD6wNFQ{QCEQvF2= MmHqV2FPT0WU
Calu-6 NHrIdFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTBwMEC0OFch|ryP NUHk[nUxW0GQR1XS
MDA-MB-453 M3zJVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTBwMEC0OVEh|ryP MVLTRW5ITVJ?
MKN45 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTBwMEC0OVMh|ryP M2fVPXNCVkeHUh?=
ECC10 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\VcmVKSzVyPUCuNFA1PiEQvF2= MWXTRW5ITVJ?
RVH-421 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYrQXpNsUUN3ME2wMlAxPDZzIN88US=> MVLTRW5ITVJ?
TGBC11TKB M1\BWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYrpbZZtUUN3ME2wMlAxPDZ7IN88US=> MWLTRW5ITVJ?
MOLT-4 NILSRXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\mTWM2OD1yLkCwOFcyKM7:TR?= MVLTRW5ITVJ?
LN-405 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHjaU2hKSzVyPUCuNFA1QDJizszN MmL5V2FPT0WU
S-117 MoH5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTBwMEC0PFYh|ryP MnO0V2FPT0WU
RPMI-8226 NVrkS2I3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF2ycldKSzVyPUCuNFA1QTdizszN MoG1V2FPT0WU
KYSE-150 MoHVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1:xXGlEPTB;MD6wNFQ6QSEQvF2= M3\4OHNCVkeHUh?=
NCI-H1666 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlvPTWM2OD1yLkCwOVA2KM7:TR?= NYDWOoxwW0GQR1XS
Mewo MnzBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlWzTWM2OD1yLkCwOVA2KM7:TR?= MWXTRW5ITVJ?
AN3-CA NHXETGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTBwMEC1NFch|ryP NHXRWoNUSU6JRWK=
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FADU M1XBUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2PVNmlEPTB;MD6wNFUyKM7:TR?= M{i5VHNCVkeHUh?=
GB-1 NYXMdWdTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHq1dHNKSzVyPUCuNFA2OTFizszN NX3qdpJvW0GQR1XS
KASUMI-1 MmXkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHjORZNKSzVyPUCuNFA2OTFizszN MnnZV2FPT0WU
NOMO-1 NIjtU4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnHMTWM2OD1yLkCwOVE{KM7:TR?= MY\TRW5ITVJ?
BV-173 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTBwMEC1N{DPxE1? MYfTRW5ITVJ?
RO82-W-1 NEPZUItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGjKe|lKSzVyPUCuNFA2OzFizszN NFPrOodUSU6JRWK=
LB2241-RCC MoLyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3e0eGlEPTB;MD6wNFU{OSEQvF2= M{e1S3NCVkeHUh?=
NCI-H2170 NYruPHNzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zYTmlEPTB;MD6wNFU{PSEQvF2= MWDTRW5ITVJ?
SK-N-AS M3X1ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk[xTWM2OD1yLkCwOVM2KM7:TR?= M3H2UnNCVkeHUh?=
NCI-H1651 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkL4TWM2OD1yLkCwOVQh|ryP NUDpTWJpW0GQR1XS
NCI-SNU-5 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\ZfWlEPTB;MD6wNFU1PSEQvF2= NIXMRoVUSU6JRWK=
SN12C M3u0dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\OWFdEUUN3ME2wMlAxPTVizszN NUTEbGFtW0GQR1XS
KY821 NXHU[lJDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUXUb|A4UUN3ME2wMlAxPTVzIN88US=> MWHTRW5ITVJ?
SW1573 NV:1WFd5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MorKTWM2OD1yLkCwOVU1KM7:TR?= M3vnUnNCVkeHUh?=
OE19 Ml7vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{Tw[GlEPTB;MD6wNFU2QSEQvF2= NWW2UWgzW0GQR1XS
MPP-89 NV7SR3V{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIK0XXVKSzVyPUCuNFA2PjdizszN MkDjV2FPT0WU
HuCCT1 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELMR3FKSzVyPUCuNFA2PjhizszN NYj2e5J5W0GQR1XS
SW1783 NGO3UJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTBwMEC1O{DPxE1? NHnub2tUSU6JRWK=
8305C NELVZ|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2X0emlEPTB;MD6wNFU4PiEQvF2= NUS2cmNkW0GQR1XS
OVCAR-4 MmTJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDJN5RKUUN3ME2wMlAxPTh4IN88US=> M4XCbHNCVkeHUh?=
MMAC-SF M2\yPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTsTWM2OD1yLkCwOVg3KM7:TR?= NYHCOIdPW0GQR1XS
COLO-824 NYjzW2hDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH\VcJJKSzVyPUCuNFA2QSEQvF2= NIHI[4xUSU6JRWK=
HCC38 NFTnR|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTBwMEC2JO69VQ>? MWDTRW5ITVJ?
NCI-H1648 NYOzOW1{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2ryWWlEPTB;MD6wNFYxOSEQvF2= NHHHWJdUSU6JRWK=
NCI-H1573 NHXwPIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWPaNINUUUN3ME2wMlAxPjB5IN88US=> NVXFPVV3W0GQR1XS
MFM-223 NFHo[llIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWL3c5RmUUN3ME2wMlAxPjF4IN88US=> MVLTRW5ITVJ?
NCI-H810 NGrmUZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXTQ[Fd1UUN3ME2wMlAxPjJ{IN88US=> M2X4fnNCVkeHUh?=
EM-2 MoD4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NES1T2NKSzVyPUCuNFA3OjNizszN MYnTRW5ITVJ?
D-283MED MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3XpcWlEPTB;MD6wNFYzPCEQvF2= M{jyXnNCVkeHUh?=
NCI-H1755 NXOxV4N3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWrJR|UxRTBwMEC2NlQh|ryP NWfuU2RLW0GQR1XS
KYSE-70 M3uzbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEHjVVhKSzVyPUCuNFA3OjRizszN M1;UUHNCVkeHUh?=
SW626 M2nlSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWD5NWc{UUN3ME2wMlAxPjJ2IN88US=> MknsV2FPT0WU
WM-115 Ml:yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml7ITWM2OD1yLkCwOlI4KM7:TR?= Mmn4V2FPT0WU
NB69 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTBwMEC2Nlkh|ryP M1;YNXNCVkeHUh?=
DOHH-2 NVXSd4ZMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEnBWnFKSzVyPUCuNFA3OyEQvF2= MWfTRW5ITVJ?
MEL-JUSO NIW3TmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX;JR|UxRTBwMEC2N|kh|ryP NXnhdllqW0GQR1XS
IGR-1 NYnBXnZzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWrJR|UxRTBwMEC2OFEh|ryP MVHTRW5ITVJ?
ACN MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHvPVXVKSzVyPUCuNFA3PDRizszN Mn3DV2FPT0WU
KARPAS-45 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYTuU4E3UUN3ME2wMlAxPjV{IN88US=> NF\Nb2lUSU6JRWK=
HC-1 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFz1eItKSzVyPUCuNFA3PTZizszN MXvTRW5ITVJ?
MZ2-MEL NGDXZopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MknETWM2OD1yLkCwOlU5KM7:TR?= NVzscmw4W0GQR1XS
NCI-H1355 NY[wVWtPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX21UYVxUUN3ME2wMlAxPjd7IN88US=> M2DWcXNCVkeHUh?=
HuP-T4 NHWyXpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlTETWM2OD1yLkCwOlc6KM7:TR?= M37Db3NCVkeHUh?=
AsPC-1 M2jkO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVPJR|UxRTBwMEC2PFMh|ryP M3y0ZXNCVkeHUh?=
SCC-15 MlX2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGf4dY9KSzVyPUCuNFA3QDlizszN MX;TRW5ITVJ?
CP50-MEL-B NFXmOHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYO2UWpnUUN3ME2wMlAxPjl|IN88US=> MX7TRW5ITVJ?
DMS-114 MkLXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml3pTWM2OD1yLkCwOlk3KM7:TR?= MXnTRW5ITVJ?
KYSE-520 M3O4dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVv0[FltUUN3ME2wMlAxPyEQvF2= NYDYdXM1W0GQR1XS
NCI-H2228 NFTKVoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTBwMEC3NlUh|ryP NWDVcIlmW0GQR1XS
COLO-829 Mn\WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTBwMEC3NlUh|ryP MmTTV2FPT0WU
NCI-H2052 MoPmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\zTWM2OD1yLkCwO|I4KM7:TR?= MWXTRW5ITVJ?
HOP-92 NXWxVFVuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmLlTWM2OD1yLkCwO|Mh|ryP MVvTRW5ITVJ?
MDA-MB-231 NGXlPVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHSfldKSzVyPUCuNFA4OyEQvF2= MX;TRW5ITVJ?
SK-MEL-30 Mm\MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYX6eYhxUUN3ME2wMlAxPzN{IN88US=> MYfTRW5ITVJ?
NCI-H2087 MoTqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH3R[HlKSzVyPUCuNFA4PDhizszN MmLXV2FPT0WU
SW900 M{ftZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnu5TWM2OD1yLkCwO|U2KM7:TR?= M2mzcHNCVkeHUh?=
NCI-H358 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoLwTWM2OD1yLkCwO|U5KM7:TR?= MYLTRW5ITVJ?
NCI-H2126 NEXl[GlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTBwMEC3O|Mh|ryP M3jmdnNCVkeHUh?=
TGBC24TKB MkLhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHTVXG5KSzVyPUCuNFA4QDFizszN NWi1SYlHW0GQR1XS
786-0 NEfyOHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlPkTWM2OD1yLkCwO|g3KM7:TR?= NX\IfGpsW0GQR1XS
no-10 NU\FcXlIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTBwMEC3PFgh|ryP MmnYV2FPT0WU
SCH M{\INWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTBwMEC4NVgh|ryP NGDPe5pUSU6JRWK=
COLO-741 M2\YfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUnhbYRXUUN3ME2wMlAxQDJizszN NYPUR3M6W0GQR1XS
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C32 MoHzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUfBUYZSUUN3ME2wMlc1OTF{IN88US=> NITrW3RUSU6JRWK=
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RCC10RGB MkHqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTBwN{mxPFMh|ryP M{XhbXNCVkeHUh?=
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NCI-H1993 MlOzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MorGTWM2OD1zLkG5Nlg6KM7:TR?= MWPTRW5ITVJ?
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... Click to View More Cell Line Experimental Data

In vivo Docetaxel (33 mg/kg/dose, given i.v. every 4 days for 3 injections) results in a tumor growth delay of 19.3 days in M2OL2 colon xenografts. Docetaxel also shows great antitumor activities in MX-1, SK-MEL-2, LX-1 and OVCAR-3 xenografts. Docetaxel inhibits the angiogenic response to fibroblast growth factor 2 with IC 50 of 5.4 mg/kg when injected twice weekly over a 14-day period, and angiogenesis is completely blocked in mice that receives 10 mg/kg Docetaxel. Docetaxel has selectivity for endothelial cell migration and/or microvessel formation because infiltration of inflammatory cells into the Matrigel plug is much less sensitive to inhibition by Docetaxel. [7]

Protocol

Cell Research:[5]
+ Expand
  • Cell lines: Human gastric cancer cell lines MKN-28
  • Concentrations: 6 nM
  • Incubation Time: 3 days
  • Method: 2000 cells in 180 μL of medium are seeded in a 96-well plate, and 20 μL of drug solution is simultaneously added in triplicate to each well. The plate is incubated for 3 days at 37°C in a humidified atmosphere of 5% CO2. On day 3, 25 μL of MTT reagent is added to each well. After 4 h of incubation, the medium is removed by aspiration. 0.2 mL of dimethylsulphoxide (DMSO) is added to each well and thoroughly mixed by using a mechanical plate mixer to dissolve the resulting MTT-formazan crystals. Absorbance at 540 nm (OD) is measured by a reader.
    (Only for Reference)
Animal Research:[6]
+ Expand
  • Animal Models: Human colon carcinomas xenografts CX-1
  • Formulation: 50 mg/mL stock solution in ethanol by adding an equal volume of polysorbate 80 and diluting with 5% dextrose in water to the final volume
  • Dosages: 33 mg/kg
  • Administration: i.v. every 4 days for 3 injections
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (123.78 mM)
Ethanol 53 mg/mL warmed (65.6 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order:
5% DMSO+30% PEG 300+5% Tween 80+ddH2O
For best results, use promptly after mixing.
2mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 807.88
Formula

C43H53NO14

CAS No. 114977-28-5
Storage powder
Synonyms RP56976, NSC 628503

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02124902 Recruiting Triple Negative Breast Neoplasms Washington University School of Medicine July 7, 2014 Phase 2
NCT01683994 Recruiting Prostatic Neoplasms National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) September 6, 2012 Phase 1|Phase 2
NCT02649855 Recruiting Prostate Cancer|Prostate Neoplasms|Neoplasms, Prostatic National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) January 4, 2016 Phase 2
NCT03041181 Recruiting Non-Squamous Non-Small Cell Lung Cancer (NSCLC)|Adenocarcinoma of the Lung|Lung Cancer Nasser Hanna, M.D.|Hoosier Cancer Research Network|Bristol-Myers Squibb January 27, 2017 Phase 2
NCT00251433 Active, not recruiting Neoplasms, Breast Novartis Pharmaceuticals|Novartis September 26, 2005 Phase 1
NCT01907529 Not yet recruiting Stage III Breast Cancer Hebei Medical University Fourth Hospital August 2018 Phase 2|Phase 3

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Microtubule Associated Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID