Docetaxel

Catalog No.S1148 Synonyms: RP56976, NSC 628503

Docetaxel Chemical Structure

Molecular Weight(MW): 807.88

Docetaxel, an analog of paclitaxel, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules.

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In DMSO USD 91 In stock
USD 70 In stock
USD 270 In stock
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5 Customer Reviews

  • Viability of cells after exposure to 0, 10, or 10,000 nM docetaxel, assessed by calcein-AM staining (green, left panels) and ethidium homodimer-1 (red, middle panels).

    Mol Pharmaceutics, 2014, 11: 2040−50. Docetaxel purchased from Selleck.

    TNBC and non-TNBC cells were treated for 6 d with the specified concentrations of docetaxel (doc) alone, TTK inhibitor (TTKi) alone or the combinations. The survival of cells was measured using the MTS/MTA assay. ***P<0.001 comparing the combination with single agents and with non-TNBC cell lines.

    Oncogenesis, 2014, 3: e100 . Docetaxel purchased from Selleck.

  • J Transl Med 2013 0.6. Docetaxel purchased from Selleck.

    J Transl Med 2013 0.6. Docetaxel purchased from Selleck.

  • Cell cycle study of percent cell populations in various phases after treatment with vehicle, HCI-2509 in increasing concentrations and docetaxel alone and in combination with HCI-2509 using (a) PC3 cells. Student's unpaired t-tests, using GraphPad Prism software, were used to calculate two-tailed P-values for each experiment to determine statistical significance between untreated and treated samples. The statistically significant P-values are labeled in each figure with an asterisk. (Replicated two more times, representative graph shown).

    Prostate Cancer Prostatic Dis, 2016, 19(4):349-357. Docetaxel purchased from Selleck.

Purity & Quality Control

Choose Selective Microtubule Associated Inhibitors

Biological Activity

Description Docetaxel, an analog of paclitaxel, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules.
Targets
Microtubules [1]
(Cell-free assay)
In vitro

Docetaxel is a cytotoxic agent, especially for proliferating cells, which is related to its ability to promote the formation of microtubule bundles and induce sustained mitotic arrest, followed by apoptosis of mitotically arrested cells or permanent mitotic block. Docetaxel suppresses microtubule dynamic instability as well as tread-milling, resulting in the failure of chromosomes to segregate to the daughter cells, which in turn triggers premature exit from mitosis rather than a block at this phase of the cell cycle. [2] Docetaxel inhibits the clonogenic survival of Human cancer cell Hs746T (stomach), AGS (stomach), HeLa (cervix), CaSki (cervix), BxPC3 (pancreas), Capan-1 (pancreas) with IC50 of 1 nM, 1 nM, 0.3 nM, 0.3 nM, 0.3 nM and 0.3 nM respectively. [4] Docetaxel inhibits endothelial cell migration that does not affects microtubule gross morphology or inhibit cell proliferation, although they does produce more subtle effects on microtubule dynamics. Docetaxel inhibits HUVEC migration with an observed IC50 of 1 pM. HUVEC chemotaxis stimulated by either of two angiogenic factors, thymidine phosphorylase or VEGF, is inhibited by Docetaxel with IC 50 of 10 pM and is ablated at 1 nM. [7] Docetaxel induces human monocytes, but not RAW 264.7 murine macrophages, Prostaglandin H Synthase-2m (PGHS-2) expression. [8]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HSC-3 NHLaO5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTBwMECwNVMzKM7:TR?= NGjBbWZUSU6JRWK=
5637 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4LTe2lEPTB;MD6wNFAyPDNizszN NITPXI5USU6JRWK=
HT-144 NEDRSHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXy4cpJqUUN3ME2wMlAxODF3NzFOwG0> M2LxNnNCVkeHUh?=
NCI-H292 M2jO[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTBwMECwNVU6KM7:TR?= MUTTRW5ITVJ?
HCE-T MmCxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnuwTWM2OD1yLkCwNFE3OiEQvF2= NIr3c5FUSU6JRWK=
ESS-1 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIfjOFVKSzVyPUCuNFAxOTd7IN88US=> M{XGW3NCVkeHUh?=
D-566MG NIGwTJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3;jO2lEPTB;MD6wNFAyQDJizszN NVPwOpR5W0GQR1XS
CAL-62 M4KxXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGHsPVZKSzVyPUCuNFAxOTh3IN88US=> MnTwV2FPT0WU
GT3TKB M2DHZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnThTWM2OD1yLkCwNFI{OiEQvF2= MW\TRW5ITVJ?
HSC-4 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTBwMECwNlM6KM7:TR?= M1m4eHNCVkeHUh?=
KOSC-2 NEDMbWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWD5dYlTUUN3ME2wMlAxODJ3NTFOwG0> M3PWfnNCVkeHUh?=
NB14 NV71XZlMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4LVXWlEPTB;MD6wNFAzPiEQvF2= NVvtSJJOW0GQR1XS
ES8 NVTEVJA6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVP1[5J6UUN3ME2wMlAxODJ4IN88US=> NYTUOppsW0GQR1XS
BFTC-905 NWntNG9PT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M37BO2lEPTB;MD6wNFAzPjhizszN MYXTRW5ITVJ?
A498 NF\3Z|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3XwdGlEPTB;MD6wNFAzPzhizszN NYDGWlBTW0GQR1XS
HO-1-N-1 NGrqN41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTBwMECwNlgyKM7:TR?= NFTUXmdUSU6JRWK=
SF539 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF7GT3ZKSzVyPUCuNFAxOzB{IN88US=> NGm1XpdUSU6JRWK=
HuO-3N1 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\2V|NKSzVyPUCuNFAxOzB{IN88US=> MXfTRW5ITVJ?
NCI-H510A MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M37iU2lEPTB;MD6wNFA{OzZizszN M2LaTHNCVkeHUh?=
CAL-27 NHzCW2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTBwMECwN|M6KM7:TR?= NGfFVGFUSU6JRWK=
TE-8 MkfIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLXTWM2OD1yLkCwNFM3PiEQvF2= NFnHT2hUSU6JRWK=
VA-ES-BJ NIH5OZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoDrTWM2OD1yLkCwNFM4PSEQvF2= MnjIV2FPT0WU
RH-1 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTBwMECwN|g3KM7:TR?= MXjTRW5ITVJ?
COLO-800 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkL5TWM2OD1yLkCwNFM5QCEQvF2= NXTJVFhKW0GQR1XS
ES7 NY\ncXZKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NULidYZ[UUN3ME2wMlAxODN6OTFOwG0> M17nRXNCVkeHUh?=
GAMG MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkjWTWM2OD1yLkCwNFQyPiEQvF2= M{fpW3NCVkeHUh?=
Ca9-22 NFfDbI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGTMdnBKSzVyPUCuNFAxPDJ|IN88US=> MkSzV2FPT0WU
SBC-1 NFywcoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{npcGlEPTB;MD6wNFA1OyEQvF2= NHr6UJRUSU6JRWK=
RPMI-7951 NHTC[ZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NETZVWxKSzVyPUCuNFAxPDR6IN88US=> MYDTRW5ITVJ?
SW1710 MnGyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmrHTWM2OD1yLkCwNFQ3PiEQvF2= M2H3c3NCVkeHUh?=
HGC-27 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHzYe4RKSzVyPUCuNFAxPDdzIN88US=> Mn;WV2FPT0WU
MC-IXC NX[wR3hkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYPxUJBnUUN3ME2wMlAxODR5OTFOwG0> NV3zblZ2W0GQR1XS
FTC-133 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTBwMECwOFg6KM7:TR?= MYPTRW5ITVJ?
HT-1080 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYfJR|UxRTBwMECwOVAyKM7:TR?= M1\kcXNCVkeHUh?=
NMC-G1 NGLLNW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvwcJBKSzVyPUCuNFAxPTF5IN88US=> NYfkSm4xW0GQR1XS
GI-1 M2HsdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXG2[VIxUUN3ME2wMlAxODV{ODFOwG0> MnS0V2FPT0WU
CGTH-W-1 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3rrRmlEPTB;MD6wNFA2PDJizszN MYjTRW5ITVJ?
A2058 NHjyS2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzIRZVIUUN3ME2wMlAxODV2NDFOwG0> M3q4[nNCVkeHUh?=
ETK-1 NInRXmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYTtRnd2UUN3ME2wMlAxODV3ODFOwG0> MW\TRW5ITVJ?
NEC8 NEO1OolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlLlTWM2OD1yLkCwNFU3OSEQvF2= NV32dplTW0GQR1XS
TE-11 MmTXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTBwMECwOVY6KM7:TR?= M12zOXNCVkeHUh?=
NCI-H720 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG[zXoFKSzVyPUCuNFAxPThizszN MknMV2FPT0WU
PSN1 MoHqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYXROmhzUUN3ME2wMlAxODV6MTFOwG0> NVXueIFKW0GQR1XS
SW780 M3jtSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3T6eWlEPTB;MD6wNFA2QDdizszN NUi4OI52W0GQR1XS
8-MG-BA NWD0SVNOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTBwMECwOVg6KM7:TR?= NIrIZWdUSU6JRWK=
EC-GI-10 NWLuT4VDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlXoTWM2OD1yLkCwNFU6OiEQvF2= M1zGWXNCVkeHUh?=
SJSA-1 M4TKfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFTEU3VKSzVyPUCuNFAxPjF3IN88US=> M{T2XHNCVkeHUh?=
639-V MoLDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTBwMECwOlQ4KM7:TR?= Mn3xV2FPT0WU
PFSK-1 MnPsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn\PTWM2OD1yLkCwNFY2PyEQvF2= NX\lNFR5W0GQR1XS
DMS-273 M321PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTBwMECwOlc1KM7:TR?= MmTSV2FPT0WU
TE-9 Mn\BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTBwMECwOlc3KM7:TR?= NGLYbYNUSU6JRWK=
SCC-25 MkOxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVmzZY1UUUN3ME2wMlAxODZ6IN88US=> M1;VXXNCVkeHUh?=
PA-1 NIjFTnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXjZcW16UUN3ME2wMlAxODZ6NzFOwG0> MULTRW5ITVJ?
MHH-ES-1 MkDPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEHUS2VKSzVyPUCuNFAxPyEQvF2= M1HXeXNCVkeHUh?=
Daoy NVriVoI1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTBwMECwO{DPxE1? NUHMc2F{W0GQR1XS
G-402 MnjoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHJR|UxRTBwMECwO|A3KM7:TR?= MXvTRW5ITVJ?
YKG-1 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M37kfGlEPTB;MD6wNFA4ODdizszN M37QfHNCVkeHUh?=
Ca-Ski NGm2[|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTBwMECwO|I5KM7:TR?= MnTnV2FPT0WU
CHP-212 NHjTPXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4jmPGlEPTB;MD6wNFA4OyEQvF2= M4PYWXNCVkeHUh?=
SCC-4 NV3GTFVCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUPMc2NuUUN3ME2wMlAxODd|OTFOwG0> NEmzTJhUSU6JRWK=
EW-3 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnNTWM2OD1yLkCwNFc1PSEQvF2= NEGx[ZJUSU6JRWK=
P12-ICHIKAWA Mlq4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjZTWM2OD1yLkCwNFc1PSEQvF2= MWHTRW5ITVJ?
HSC-2 NGr0PHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIr5bIZKSzVyPUCuNFAxPzV3IN88US=> NGHHOnpUSU6JRWK=
HN M2rhVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEnzWYhKSzVyPUCuNFAxPzV6IN88US=> MnrLV2FPT0WU
LXF-289 M1G5Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{SxUGlEPTB;MD6wNFA4PThizszN NYXJ[VhTW0GQR1XS
ES1 Mle0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTBwMECwO|ch|ryP NIGyRYtUSU6JRWK=
NTERA-S-cl-D1 NVHTRlJTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoGxTWM2OD1yLkCwNFc4OyEQvF2= M4rER3NCVkeHUh?=
K5 MoWzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYTJR|UxRTBwMECwO|c5KM7:TR?= NWD0eVVpW0GQR1XS
HOS NWr1cY41T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUPJR|UxRTBwMECwO|gzKM7:TR?= NEfhVlVUSU6JRWK=
YH-13 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXRbWI{UUN3ME2wMlAxODd7MTFOwG0> NVWwdoI3W0GQR1XS
SW954 NWDkbYpnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoKxTWM2OD1yLkCwNFgzOyEQvF2= NGDrenZUSU6JRWK=
KYSE-510 NUC3TmFIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2G2VWlEPTB;MD6wNFA5PCEQvF2= NUW0TotSW0GQR1XS
8505C MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV3GVYtlUUN3ME2wMlAxODh3NDFOwG0> MVrTRW5ITVJ?
A549 NITHRlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFq2e3NKSzVyPUCuNFAxQDh{IN88US=> NV7DRVRNW0GQR1XS
Detroit562 NYXmbotDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGDV[mhKSzVyPUCuNFAxQTB{IN88US=> MWrTRW5ITVJ?
ES5 M4fQPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVXhW5lJUUN3ME2wMlAxODlzIN88US=> NX;ibWF3W0GQR1XS
KYSE-140 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGSwSVNKSzVyPUCuNFAxQTN|IN88US=> MVzTRW5ITVJ?
GMS-10 NFnqRnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIP4UIhKSzVyPUCuNFAxQTRzIN88US=> MnjUV2FPT0WU
D-263MG MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTBwMECwPVQ4KM7:TR?= Mn\KV2FPT0WU
BCPAP NXHDV5ZOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWDjXGVIUUN3ME2wMlAxODl2NzFOwG0> M3iwUXNCVkeHUh?=
CHL-1 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV3MZmIzUUN3ME2wMlAxODl3ODFOwG0> M13MfnNCVkeHUh?=
RKO MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NInKdXlKSzVyPUCuNFAxQTh7IN88US=> MULTRW5ITVJ?
SW48 NFLKVVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1ToR2lEPTB;MD6wNFExOSEQvF2= NXLofmprW0GQR1XS
BPH-1 NXTlfJY5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTBwMECxNFIh|ryP NGLLWodUSU6JRWK=
EFO-27 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4q3UmlEPTB;MD6wNFExOiEQvF2= MlTOV2FPT0WU
CAL-33 M3XrcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH\sRWxKSzVyPUCuNFAyODRizszN MmTLV2FPT0WU
NCI-H1792 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTBwMECxNFQh|ryP MYjTRW5ITVJ?
BB30-HNC MnPGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTBwMECxNFUh|ryP MX\TRW5ITVJ?
VM-CUB-1 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTBwMECxNFUh|ryP NUnRfYQ6W0GQR1XS
TE-5 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3G5NWlEPTB;MD6wNFExPiEQvF2= NXnUWJFlW0GQR1XS
NB13 NYnBdndbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MofLTWM2OD1yLkCwNVA4KM7:TR?= NVfUXG5sW0GQR1XS
NBsusSR M2foeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTBwMECxNUDPxE1? MYfTRW5ITVJ?
LNCaP-Clone-FGC MonjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlrFTWM2OD1yLkCwNVEh|ryP MV3TRW5ITVJ?
EPLC-272H MnfXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF\zeWNKSzVyPUCuNFAyOTFizszN NWjmSnVoW0GQR1XS
KNS-62 NYX0N2dQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHjDZnVKSzVyPUCuNFAyOTJizszN M1jNTnNCVkeHUh?=
RERF-LC-MS Ml7VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnnWTWM2OD1yLkCwNVE{KM7:TR?= NXnyU41oW0GQR1XS
LOXIMVI M2LEe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEjCfI5KSzVyPUCuNFAyOTZizszN NFS5ZXlUSU6JRWK=
KINGS-1 MnT3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M376fWlEPTB;MD6wNFEyPyEQvF2= NGPvbmNUSU6JRWK=
T98G MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoOxTWM2OD1yLkCwNVE4KM7:TR?= Ml61V2FPT0WU
HCC1806 MnXRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk[0TWM2OD1yLkCwNVE5KM7:TR?= Mn\LV2FPT0WU
MZ1-PC NXO5ZY81T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVfScZpNUUN3ME2wMlAxOTF6IN88US=> MYTTRW5ITVJ?
RT-112 M2XMWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1Xyb2lEPTB;MD6wNFEyQSEQvF2= MYfTRW5ITVJ?
LK-2 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\iTWM2OD1yLkCwNVIyKM7:TR?= NWnKN5pOW0GQR1XS
A375 NHTBZnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTBwMECxNlEh|ryP MVnTRW5ITVJ?
SF268 NYDMU4w3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXT3N4htUUN3ME2wMlAxOTJzIN88US=> NYj4Wo1qW0GQR1XS
H9 MlO3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGPldoJKSzVyPUCuNFAyOjRizszN M2\2cnNCVkeHUh?=
KYSE-410 M4rYRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYfJUFdjUUN3ME2wMlAxOTJ2IN88US=> MW\TRW5ITVJ?
G-401 MlrFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTBwMECxNlch|ryP M4foR3NCVkeHUh?=
SW982 NVe4c3pOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYDJbVhjUUN3ME2wMlAxOTJ5IN88US=> NYXmemRiW0GQR1XS
D-423MG NI\jbVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3G2SWlEPTB;MD6wNFE{KM7:TR?= M1vXZXNCVkeHUh?=
CAMA-1 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTBwMECxN|Eh|ryP MVLTRW5ITVJ?
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SAS Mme3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHqTWM2OD1yLkCwNVM1KM7:TR?= NWLFbohvW0GQR1XS
KYSE-180 NH30U2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MorsTWM2OD1yLkCwNVM2KM7:TR?= MYXTRW5ITVJ?
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HD-MY-Z NEXWUWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTBwMECxOFEh|ryP NIPrdoNUSU6JRWK=
KYSE-450 MlXkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mmf6TWM2OD1yLkCwNVQ{KM7:TR?= NIDBPHhUSU6JRWK=
LCLC-97TM1 NVvCVId3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTBwMECxOFQh|ryP M2LNZnNCVkeHUh?=
KS-1 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkDBTWM2OD1yLkCwNVQ1KM7:TR?= MmjLV2FPT0WU
TI-73 MnfUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3e5UGlEPTB;MD6wNFE1PCEQvF2= NGrvOoNUSU6JRWK=
A427 M2HwPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTBwMECxOFgh|ryP MnWxV2FPT0WU
LB831-BLC NWDFUWQ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTBwMECxOFgh|ryP M1;YfXNCVkeHUh?=
MG-63 NID6Oo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4DQPGlEPTB;MD6wNFE2OSEQvF2= MUDTRW5ITVJ?
PANC-03-27 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTBwMECxOVQh|ryP NUWwTFNNW0GQR1XS
23132-87 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoHaTWM2OD1yLkCwNVU2KM7:TR?= MnuyV2FPT0WU
ES4 NGf1NIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzUOpp[UUN3ME2wMlAxOTV3IN88US=> M{GxbnNCVkeHUh?=
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NCI-H1703 MmW0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWSxZWVEUUN3ME2wMlAxOTV5IN88US=> NUO0VGFsW0GQR1XS
MCF7 NVi0eINHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTBwMECxOlEh|ryP MXjTRW5ITVJ?
A172 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mli5TWM2OD1yLkCwNVY{KM7:TR?= MkfVV2FPT0WU
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Saos-2 NULQfm5LT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUPJR|UxRTBwMECxOlgh|ryP M3TieHNCVkeHUh?=
EW-11 MmfCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnvlTWM2OD1yLkCwNVY6KM7:TR?= NYjNeYdyW0GQR1XS
D-336MG MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NETre5ZKSzVyPUCuNFAyPjlizszN M3fDfXNCVkeHUh?=
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ME-180 M2XRemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUX0V5hqUUN3ME2wMlAxOTZ7IN88US=> M4nFcHNCVkeHUh?=
SK-MEL-2 NGjyV5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTBwMECxO{DPxE1? M33W[3NCVkeHUh?=
697 NIPBfWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlrFTWM2OD1yLkCwNVczKM7:TR?= M4fqZ3NCVkeHUh?=
D-247MG NH;0XndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M33GXGlEPTB;MD6wNFE4OyEQvF2= MnHnV2FPT0WU
EoL-1-cell NVXwWHlqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVKzd5k4UUN3ME2wMlAxOTd|IN88US=> M3:5eHNCVkeHUh?=
MV-4-11 M3PVeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2LYSmlEPTB;MD6wNFE4PCEQvF2= MkXtV2FPT0WU
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NCI-H526 NWTwSWdFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXqyc4Y2UUN3ME2wMlAxOTd4IN88US=> NX[1TndSW0GQR1XS
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DB NYPHVII3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTBwMECxO|gh|ryP MVjTRW5ITVJ?
GCT NVPMV5JoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTBwMECxPEDPxE1? MXHTRW5ITVJ?
HCT-116 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUDlXWRTUUN3ME2wMlAxOThzIN88US=> Mk\KV2FPT0WU
AU565 M{fabGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH7uOGtKSzVyPUCuNFAyQDFizszN MormV2FPT0WU
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C2BBe1 M2rrbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYLSPWNoUUN3ME2wMlAxOTh{IN88US=> M{\hbHNCVkeHUh?=
Becker MmrPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTBwMECxPFMh|ryP MmC0V2FPT0WU
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SBC-5 MmnpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYnJUpg{UUN3ME2wMlAxOTh5IN88US=> MmjwV2FPT0WU
NB17 NX\ZbmF3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWDKTGdMUUN3ME2wMlAxOTh7IN88US=> MmHYV2FPT0WU
MHH-PREB-1 NXjFV4YzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWTMXVNCUUN3ME2wMlAxOTh7IN88US=> MWXTRW5ITVJ?
M14 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYnoOIxtUUN3ME2wMlAxOTlzIN88US=> M4WzcnNCVkeHUh?=
NCI-H1048 M1XxbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHXpXZFKSzVyPUCuNFAyQTJizszN NVzSb5V6W0GQR1XS
CTB-1 MnLNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXTxemQ3UUN3ME2wMlAxOTl{IN88US=> M2LldnNCVkeHUh?=
SK-PN-DW MnfoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTBwMECxPVQh|ryP NX32fGx6W0GQR1XS
H4 MnHWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHvlU|NKSzVyPUCuNFAyQTZizszN Mm\WV2FPT0WU
NCI-SNU-1 MkK2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHJR|UxRTBwMECxPVch|ryP NI\WbYpUSU6JRWK=
M059J NHf6[Y5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI[2[5FKSzVyPUCuNFAyQThizszN NHviW4JUSU6JRWK=
OVCAR-5 MljFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2PST2lEPTB;MD6wNFE6QSEQvF2= NV62fIVkW0GQR1XS
SK-MEL-28 NXzoeJVXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTBwMECyNFMh|ryP NGHqfJVUSU6JRWK=
PC-14 NYXaOWVGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTBwMECyNFkh|ryP MmO4V2FPT0WU
OVCAR-8 NFnwbFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXT2TpF3UUN3ME2wMlAxOjF{IN88US=> NHTrcZdUSU6JRWK=
BB49-HNC MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmXiTWM2OD1yLkCwNlEzKM7:TR?= NX\1RpdnW0GQR1XS
EFM-19 M{LOdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUX6Zo5VUUN3ME2wMlAxOjF3IN88US=> NYLZXFlkW0GQR1XS
BHY MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF2wO4RKSzVyPUCuNFAzOTZizszN NETwPWZUSU6JRWK=
SW756 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTBwMECyNVYh|ryP MXzTRW5ITVJ?
TE-1 NU\Xbo1QT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPtcHdwUUN3ME2wMlAxOjF4IN88US=> MUPTRW5ITVJ?
NCI-H2452 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHfTb2lKSzVyPUCuNFAzOTZizszN MYTTRW5ITVJ?
NCI-H1581 MlHiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTBwMECyNVch|ryP M1PBSXNCVkeHUh?=
COR-L23 NVzBbo9pT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUHTUmNDUUN3ME2wMlAxOjJizszN M17HTnNCVkeHUh?=
RXF393 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkHzTWM2OD1yLkCwNlIzKM7:TR?= Mo\ZV2FPT0WU
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NCI-H650 M{ixVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHvwb25KSzVyPUCuNFAzOjVizszN Mn;TV2FPT0WU
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SK-MES-1 MlL2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTBwMECyN|Mh|ryP M1i0W3NCVkeHUh?=
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HCE-4 NX7r[|ZkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1PkWWlEPTB;MD6wNFI1PyEQvF2= M{fBWXNCVkeHUh?=
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NCI-H1437 NXTQUmU5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfJR|UxRTBwMECyOkDPxE1? M1TKW3NCVkeHUh?=
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Hs-578-T MofjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYXZUGI3UUN3ME2wMlAxOjd{IN88US=> MorxV2FPT0WU
MDA-MB-415 NWTuV5A2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlq3TWM2OD1yLkCwNlc1KM7:TR?= Mn6xV2FPT0WU
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KYSE-270 MkT4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\kTWM2OD1yLkCwNlc5KM7:TR?= NYTNOVRRW0GQR1XS
HT-29 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTBwMECyPEDPxE1? NV\OPVkxW0GQR1XS
MDA-MB-361 NF;3[lNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUS1XVdvUUN3ME2wMlAxOjhzIN88US=> NH;OUINUSU6JRWK=
RPMI-8866 NU\4WnlKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHXDTmFKSzVyPUCuNFAzQDFizszN Mk\yV2FPT0WU
JEG-3 NH3qWVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4raVmlEPTB;MD6wNFI5OiEQvF2= M3fJdnNCVkeHUh?=
HT-3 M{Xpd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn3BTWM2OD1yLkCwNlgzKM7:TR?= M2LURXNCVkeHUh?=
HTC-C3 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlO3TWM2OD1yLkCwNlg2KM7:TR?= NUjPd5dpW0GQR1XS
NCI-H209 NG\2fVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\ONGlEPTB;MD6wNFI5PiEQvF2= NI\oN3ZUSU6JRWK=
SKG-IIIa NHjwdnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\yOmEzUUN3ME2wMlAxOjh4IN88US=> NFv2PWNUSU6JRWK=
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LCLC-103H NG\aOVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2rLemlEPTB;MD6wNFI6OyEQvF2= MYjTRW5ITVJ?
DOK MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTBwMECyPVQh|ryP NVPiR4VUW0GQR1XS
SW1088 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHTXUVlKSzVyPUCuNFAzQTVizszN MlvZV2FPT0WU
GP5d M2LjWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWLy[ZZ{UUN3ME2wMlAxOjl4IN88US=> NYr4dmFJW0GQR1XS
EW-1 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1fOOWlEPTB;MD6wNFI6QCEQvF2= MVfTRW5ITVJ?
CP66-MEL NFHVUVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTBwMECzJO69VQ>? NEf2WJdUSU6JRWK=
DEL M2nVbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlHHTWM2OD1yLkCwN|AyKM7:TR?= M4HsenNCVkeHUh?=
DU-4475 Mn3LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFi1dZZKSzVyPUCuNFA{ODJizszN M3HS[3NCVkeHUh?=
HEC-1 NF3xb3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTBwMECzNFMh|ryP NIL0VotUSU6JRWK=
U031 NITBd45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWXaR2dPUUN3ME2wMlAxOzB5IN88US=> M{HiSnNCVkeHUh?=
BB65-RCC MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTBwMECzNFgh|ryP MWLTRW5ITVJ?
NUGC-3 NHraNodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYfyNmZCUUN3ME2wMlAxOzB6IN88US=> MojqV2FPT0WU
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LS-411N NE\q[lRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTBwMECzNVQh|ryP Mm\hV2FPT0WU
22RV1 MkPJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmDETWM2OD1yLkCwN|E2KM7:TR?= NYLKfnNzW0GQR1XS
MKN28 Mlz0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIDm[WZKSzVyPUCuNFA{OTdizszN MULTRW5ITVJ?
ONS-76 NUXvW5ROT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MknqTWM2OD1yLkCwN|IzKM7:TR?= M1\JUXNCVkeHUh?=
SH-4 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX7tRZRIUUN3ME2wMlAxOzJ{IN88US=> MY\TRW5ITVJ?
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SF126 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX\aVmdRUUN3ME2wMlAxOzJ7IN88US=> NUG3[|Y{W0GQR1XS
UACC-62 NHzKNJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2W5TGlEPTB;MD6wNFM{KM7:TR?= MorRV2FPT0WU
NCI-H28 NXO0Z2tUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;EdWs1UUN3ME2wMlAxOzN2IN88US=> NE\sTnhUSU6JRWK=
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L-363 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLJR|UxRTBwMECzO|Yh|ryP MXjTRW5ITVJ?
CAL-12T M1rwOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfXTWM2OD1yLkCwN|c3KM7:TR?= MnTUV2FPT0WU
BT-20 M4PCdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUHjc3hkUUN3ME2wMlAxOzd4IN88US=> MnHsV2FPT0WU
SNB75 NHXqfFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX;JR|UxRTBwMECzPFEh|ryP MnLLV2FPT0WU
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BE-13 MlPCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXXSfnZWUUN3ME2wMlAxOzl|IN88US=> MkezV2FPT0WU
NCI-H1395 Mn3iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{TuTmlEPTB;MD6wNFM6PiEQvF2= MVjTRW5ITVJ?
SW620 M1TBRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWi4UI5JUUN3ME2wMlAxOzl5IN88US=> NIDBdGdUSU6JRWK=
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OVCAR-3 NU\6S2ZiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTBwMEC0NFch|ryP M2\pWXNCVkeHUh?=
KM12 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTBwMEC0NFgh|ryP M{DlVnNCVkeHUh?=
HCC2998 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4Oyb2lEPTB;MD6wNFQxQCEQvF2= MYjTRW5ITVJ?
D-502MG M{D0VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\jbpNzUUN3ME2wMlAxPDFizszN MkOwV2FPT0WU
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EW-24 MliwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2TENGlEPTB;MD6wNFQ{OyEQvF2= MmnQV2FPT0WU
CAL-120 NHnQN4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTBwMEC0N|Uh|ryP M{L1eXNCVkeHUh?=
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Calu-6 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\TXFBKUUN3ME2wMlAxPDR5IN88US=> M1e5XXNCVkeHUh?=
MDA-MB-453 MlyyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTBwMEC0OVEh|ryP Mk\BV2FPT0WU
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RVH-421 M1vRO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXOx[4I3UUN3ME2wMlAxPDZzIN88US=> MYHTRW5ITVJ?
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LN-405 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWfxTnNNUUN3ME2wMlAxPDh{IN88US=> MnjXV2FPT0WU
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RPMI-8226 MmL2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTBwMEC0PVch|ryP MnS1V2FPT0WU
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Mewo Mkj0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NG[0XpFKSzVyPUCuNFA2ODVizszN NITUVGpUSU6JRWK=
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COLO-680N MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTBwMEC1NFgh|ryP MmD0V2FPT0WU
FADU NI\iXphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTBwMEC1NUDPxE1? MonuV2FPT0WU
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BV-173 M4jJSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmHkTWM2OD1yLkCwOVMh|ryP NVjiTFluW0GQR1XS
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LB2241-RCC M{m0Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NELxV2RKSzVyPUCuNFA2OzFizszN NWK4RWNXW0GQR1XS
NCI-H2170 NUfYdIY3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4[wSmlEPTB;MD6wNFU{PSEQvF2= NFvpfZhUSU6JRWK=
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NCI-H1651 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYi4PXp4UUN3ME2wMlAxPTRizszN MnXkV2FPT0WU
NCI-SNU-5 NX\sS25ZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\kNo5QUUN3ME2wMlAxPTR3IN88US=> MVjTRW5ITVJ?
SN12C NVexcJJIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlq1TWM2OD1yLkCwOVUh|ryP NETLWIlUSU6JRWK=
KY821 NYPZPW5TT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3aZ3VrUUN3ME2wMlAxPTVzIN88US=> NEXQdVlUSU6JRWK=
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MPP-89 MlnpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2fZcmlEPTB;MD6wNFU3PyEQvF2= NVHv[JlUW0GQR1XS
HuCCT1 M3jYeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2jhbGlEPTB;MD6wNFU3QCEQvF2= M3nocHNCVkeHUh?=
SW1783 MlvvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTBwMEC1O{DPxE1? MXfTRW5ITVJ?
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OVCAR-4 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRTBwMEC1PFYh|ryP MWrTRW5ITVJ?
MMAC-SF NH[2WVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYDMSpdSUUN3ME2wMlAxPTh4IN88US=> NIK1WJRUSU6JRWK=
COLO-824 NYfIbIE1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUPJR|UxRTBwMEC1PUDPxE1? MkjNV2FPT0WU
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NCI-H1648 NETOdXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTBwMEC2NFEh|ryP M3fNNXNCVkeHUh?=
NCI-H1573 M16w[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkDnTWM2OD1yLkCwOlA4KM7:TR?= M4SzXHNCVkeHUh?=
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NCI-H810 NFexOHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVfRcllHUUN3ME2wMlAxPjJ{IN88US=> NWDTW2c6W0GQR1XS
EM-2 M1vINGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\tTWM2OD1yLkCwOlI{KM7:TR?= M2\BcnNCVkeHUh?=
D-283MED MoDLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfzTWM2OD1yLkCwOlI1KM7:TR?= Mn3CV2FPT0WU
NCI-H1755 NGfQbnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnGzTWM2OD1yLkCwOlI1KM7:TR?= NV\SW3U4W0GQR1XS
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WM-115 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4f4WmlEPTB;MD6wNFYzPyEQvF2= NHvYfHRUSU6JRWK=
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MZ2-MEL MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{GwS2lEPTB;MD6wNFY2QCEQvF2= MoW1V2FPT0WU
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AsPC-1 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIfDcplKSzVyPUCuNFA3QDNizszN MXPTRW5ITVJ?
SCC-15 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUnJUmhJUUN3ME2wMlAxPjh7IN88US=> NWHkWlBrW0GQR1XS
CP50-MEL-B NHj6eJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUi4WZh3UUN3ME2wMlAxPjl|IN88US=> M3K0TXNCVkeHUh?=
DMS-114 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTBwMEC2PVYh|ryP Ml[yV2FPT0WU
KYSE-520 NYP4OVdZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGnpUmJKSzVyPUCuNFA4KM7:TR?= NVHDS2Y3W0GQR1XS
NCI-H2228 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4\SUGlEPTB;MD6wNFczPSEQvF2= NIHlbpRUSU6JRWK=
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NCI-H2052 NInYVmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1e2RmlEPTB;MD6wNFczPyEQvF2= MXfTRW5ITVJ?
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NCI-H2087 M{jEUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGm0d4FKSzVyPUCuNFA4PDhizszN NVex[JgyW0GQR1XS
SW900 M4rnUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX3KR4NXUUN3ME2wMlAxPzV3IN88US=> M1\KUXNCVkeHUh?=
NCI-H358 NW\1V4drT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVnrcIJRUUN3ME2wMlAxPzV6IN88US=> M2fCOnNCVkeHUh?=
NCI-H2126 M33xS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHu0S4RKSzVyPUCuNFA4PzNizszN NWDNdYg1W0GQR1XS
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786-0 MkTXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\TS4ZUUUN3ME2wMlAxPzh4IN88US=> MVvTRW5ITVJ?
no-10 NF;6O|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3XTZNkUUN3ME2wMlAxPzh6IN88US=> MWrTRW5ITVJ?
SCH NI\5c3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWfmbGNoUUN3ME2wMlAxQDF6IN88US=> MkjFV2FPT0WU
COLO-741 NWi5SYFoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTBwMEC4NkDPxE1? M3ntcHNCVkeHUh?=
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Calu-3 NEn6PIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEXpe4FKSzVyPUCuNVM5OTZizszN MU\TRW5ITVJ?
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NCI-H1304 MnfQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTBwMU[wOlEh|ryP MUTTRW5ITVJ?
D-542MG MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTBwMU[yO|gh|ryP MVnTRW5ITVJ?
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NCI-H2029 NFzy[plIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\yTWM2OD1yLkKwNlQ{KM7:TR?= NVfZfm1QW0GQR1XS
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CCRF-CEM NXPNU25nT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NImyO3lKSzVyPUCuNlc3OTRizszN NXLsTolJW0GQR1XS
LU-135 M2O1O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGLDU4ZKSzVyPUCuNlc4OzlizszN MVHTRW5ITVJ?
MC116 MoLVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NInIVohKSzVyPUCuNlg{ODlizszN NU[xTVY6W0GQR1XS
LS-513 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXXKfoFoUUN3ME2wMlI5Pzd|IN88US=> MoXvV2FPT0WU
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L-428 NFvZ[WJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTBwMkm4PFMh|ryP MkHUV2FPT0WU
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NCI-H1838 NUXLNXRtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIXkPG1KSzVyPUCuN|E4QDRizszN MoTDV2FPT0WU
HEL M1\IXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2PDVWlEPTB;MD6zNlI1KM7:TR?= NEPxeVdUSU6JRWK=
OCI-AML2 M1XpZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTBwM{KyPVgh|ryP M3nCV3NCVkeHUh?=
A3-KAW MmfSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTBwM{O0O|ch|ryP M2D0dHNCVkeHUh?=
IGROV-1 NWDmXXVtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEjSR2VKSzVyPUCuN|M4PTVizszN NI\QemdUSU6JRWK=
Mo-T Moi3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTBwM{O4OVMh|ryP MoLKV2FPT0WU
HDLM-2 M3ntOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTBwM{O5JO69VQ>? Mnf3V2FPT0WU
HCC1569 NFXQNFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUeyXGVzUUN3ME2wMlM1OzB7IN88US=> MmXsV2FPT0WU
COLO-678 M{X3cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTBwM{ewNFIh|ryP MkPiV2FPT0WU
COR-L105 NIPxWohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3qyPGlEPTB;MD6zO|k{KM7:TR?= NYm1SoxoW0GQR1XS
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C8166 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIDlSVVKSzVyPUCuOFkxOjNizszN NIGxcG5USU6JRWK=
COLO-679 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkHiTWM2OD1yLk[yNVczKM7:TR?= NV33PFFFW0GQR1XS
TE-12 NIfKco9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEHKV4tKSzVyPUCuOlU{QTRizszN NWfhV|hOW0GQR1XS
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SNU-449 NHvlVHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\GO2tKSzVyPUCuO|I4PDhizszN MV3TRW5ITVJ?
C32 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTBwN{SxNVIh|ryP MlK1V2FPT0WU
K-562 MnjZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI[3S3dKSzVyPUCuO|cxOjRizszN MWrTRW5ITVJ?
DJM-1 M2PpSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIrmPXNKSzVyPUCuO|g4QDFizszN NYSxRo1DW0GQR1XS
RCC10RGB NV7ubmoxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRTBwN{mxPFMh|ryP NE\Fc4JUSU6JRWK=
CAL-85-1 Ml\SS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{TWd2lEPTB;MD65NFch|ryP MWfTRW5ITVJ?
NY M{XNSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3HOUWlEPTB;MD65N|M2OiEQvF2= M4HvN3NCVkeHUh?=
NCI-H1993 MlTuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXjoNop1UUN3ME2xMlE6Ojh7IN88US=> NUXEPIkyW0GQR1XS
SK-OV-3 NGnTS2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkKyTWM2OD1zLkKyNFg6KM7:TR?= NWryVJc6W0GQR1XS

... Click to View More Cell Line Experimental Data

In vivo Docetaxel (33 mg/kg/dose, given i.v. every 4 days for 3 injections) results in a tumor growth delay of 19.3 days in M2OL2 colon xenografts. Docetaxel also shows great antitumor activities in MX-1, SK-MEL-2, LX-1 and OVCAR-3 xenografts. Docetaxel inhibits the angiogenic response to fibroblast growth factor 2 with IC 50 of 5.4 mg/kg when injected twice weekly over a 14-day period, and angiogenesis is completely blocked in mice that receives 10 mg/kg Docetaxel. Docetaxel has selectivity for endothelial cell migration and/or microvessel formation because infiltration of inflammatory cells into the Matrigel plug is much less sensitive to inhibition by Docetaxel. [7]

Protocol

Cell Research:[5]
+ Expand
  • Cell lines: Human gastric cancer cell lines MKN-28
  • Concentrations: 6 nM
  • Incubation Time: 3 days
  • Method: 2000 cells in 180 μL of medium are seeded in a 96-well plate, and 20 μL of drug solution is simultaneously added in triplicate to each well. The plate is incubated for 3 days at 37°C in a humidified atmosphere of 5% CO2. On day 3, 25 μL of MTT reagent is added to each well. After 4 h of incubation, the medium is removed by aspiration. 0.2 mL of dimethylsulphoxide (DMSO) is added to each well and thoroughly mixed by using a mechanical plate mixer to dissolve the resulting MTT-formazan crystals. Absorbance at 540 nm (OD) is measured by a reader.
    (Only for Reference)
Animal Research:[6]
+ Expand
  • Animal Models: Human colon carcinomas xenografts CX-1
  • Formulation: 50 mg/mL stock solution in ethanol by adding an equal volume of polysorbate 80 and diluting with 5% dextrose in water to the final volume
  • Dosages: 33 mg/kg
  • Administration: i.v. every 4 days for 3 injections
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (123.78 mM)
Ethanol 53 mg/mL warmed (65.6 mM)
Water Insoluble
In vivo Add solvents individually and in order:
5% DMSO+30% PEG 300+5% Tween 80+ddH2O
2mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 807.88
Formula

C43H53NO14

CAS No. 114977-28-5
Storage powder
Synonyms RP56976, NSC 628503

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02124902 Recruiting Triple Negative Breast Neoplasms Washington University School of Medicine July 7, 2014 Phase 2
NCT01683994 Recruiting Prostatic Neoplasms National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) September 6, 2012 Phase 1|Phase 2
NCT02649855 Recruiting Prostate Cancer|Prostate Neoplasms|Neoplasms, Prostatic National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) January 4, 2016 Phase 2
NCT03041181 Recruiting Non-Squamous Non-Small Cell Lung Cancer (NSCLC)|Adenocarcinoma of the Lung|Lung Cancer Nasser Hanna, M.D.|Hoosier Cancer Research Network|Bristol-Myers Squibb January 27, 2017 Phase 2
NCT00251433 Active, not recruiting Neoplasms, Breast Novartis Pharmaceuticals|Novartis September 26, 2005 Phase 1
NCT01907529 Not yet recruiting Stage III Breast Cancer Hebei Medical University Fourth Hospital August 2018 Phase 2|Phase 3

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID