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Topoisomerase Inhibitors (34)


Cat.No. Product Name Information Product Use Citation Customer Product Validation
S1208 Doxorubicin (Adriamycin) Doxorubicin (Adriamycin) is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis in tumor cells.
  • Sci Transl Med, 2015, 7(284):284ra57
  • Nat Commun, 2014, 5:3384
  • Proc Natl Acad Sci USA, 2015, 112(6):1839-44
S1225 Etoposide Etoposide is a semisynthetic derivative of podophyllotoxin, which inhibits DNA synthesis via topoisomerase II inhibition activity.
  • Leukemia, 2015, 10.1038/leu.2015.99
  • Cancer Res, 2011, 71(13):4707-19
  • Oncogene, 2016, 10.1038/onc.2016.247
S1288 Camptothecin Camptothecin is a specific inhibitor of DNA topoisomerase I (Topo I) with IC50 of 0.68 μM in a cell-free assay. Phase 2.
  • Nature, 2015, 522(7557):492-6
  • EMBO Rep, 2010, 11(12):962-8
  • Mol Cancer Ther, 2012, 11(12):2633-43
S1231 Topotecan HCl Topotecan HCl is a topoisomerase I inhibitor for MCF-7 Luc cells and DU-145 Luc cells with IC50 of 13 nM and 2 nM in cell-free assays, respectively.
  • Nat Chem Biol, 2014, 10(9):768-73
  • PLoS Genet, 2014, 10(1):e1004107
  • Mol Cancer, 2015, 14(1):92
S1198 Irinotecan Irinotecan is a topoisomerase I inhibitor for LoVo cells and HT-29 cells with IC50 of 15.8 μM and 5.17 μM, respectively.
  • Biomaterials, 2015, 72:74-89
S1228 Idarubicin HCl Idarubicin HCl is a hydrochloride salt form of Idarubicin which is an anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells with IC50 of 3.3 ng/mL in a cell-free assay.
  • Nat Chem Biol, 2014, 10(9):768-73
  • Mol Cancer Ther, 2013, 12(7):1299-309
  • J Phys Chem B, 2013, 117(23):6868-73
S1223 Epirubicin HCl Epirubicin HCl, a semisynthetic L-arabino derivative of doxorubicin, is an antineoplastic agent by inhibiting Topoisomerase.
S2485 Mitoxantrone HCl Mitoxantrone is a type II topoisomerase inhibitor with IC50 of 2.0 μM, 0.42 mM for HepG2 and MCF-7/wt cells, respectively.
S3035 Daunorubicin HCl Daunorubicin HCl inhibits both DNA and RNA synthesis and inhibits DNA synthesis with Ki of 0.02 μM in a cell-free assay.
  • J Phys Chem B, 2013, 117(23):6868-73
  • Leuk Res, 2015, 39(4):435-44
  • Toxicology Reports, 2016, 10.1016/j.toxrep.2016.03.008
S1465 Moxifloxacin HCl Moxifloxacin is a fourth-generation synthetic fluoroquinolone antibacterial agent.
  • Sci Rep, 2013, 3:2101
Cat.No. Product Name Information Product Use Citation Customer Product Validation
S2217 Irinotecan HCl Trihydrate Irinotecan prevents DNA from unwinding by inhibition of topoisomerase 1.
S4908 SN-38 SN-38 is an active metabolite of CPT-11, inhibits DNA topoisomerase I, DNA synthesis and causes frequent DNA single-strand breaks.
  • J Pharmacol Exp Ther, 2014, 348(3):432-41
  • PLoS One, 2015, 10(11):e0142704
  • J Am Soc Mass Spectrom, 2015, 26(4):577-86
S1367 Amonafide Amonafide produces protein-associated DNA-strand breaks through a topoisomerase II-mediated reaction, but does not produce topoisomerase I-mediated DNA cleavage. Phase 3.
  • Theranostics, 2015, 5(5): 477-488
  • Bioorg Med Chem, 2015, 23(17):5672-80
S1787 Teniposide Teniposide is a chemotherapeutic medication mainly used in the treatment of childhood acute lymphocytic leukemia (ALL).
S1340 Gatifloxacin Gatifloxacin is an antibiotic of the fourth-generation fluoroquinolone family, and inhibits the bacterial enzymes DNA gyrase and topoisomerase IV.
  • Biochem Pharmacol, 2015, 95(4):227-37
S1342 Genistein Genistein, a phytoestrogen found in soy products, is a highly specific inhibitor of protein tyrosine kinase (PTK) which blocks the mitogenic effect mediated by EGF on NIH-3T3 cells with IC50 of 12μM or by insulin with IC50 of 19 μM.
  • J Electroanal Chem, 2015, 742:54–61
S1889 Mitoxantrone Mitoxantrone is a type II topoisomerase inhibitor with IC50 of 2.0 μM, 0.42 mM for HepG2 and MCF-7/wt cells, respectively.
  • Electrochimica Acta, 2015, 10.1016/j.electacta.2015.02.223
S1940 Levofloxacin Levofloxacin is a broad-spectrum antibiotic topoisomerase II and topoisomerase IV inhibitor, used to treat respiratory, urinary tract, gastrointestinal, and abdominal infections.
S1393 Pirarubicin Pirarubicin is an anthracycline antibiotic, and also a DNA/RNA synthesis inhibitor by intercalating into DNA and interacts with topoisomerase II, used as an antineoplastic agent.
S2027 Ciprofloxacin Ciprofloxacin is a fluoroquinolone antibiotic, shows broad and potent antibacterial activity, with MIC90 of 0.024-6 μM.
  • Cancer Res, 2012, 72(23):6200-8
Cat.No. Product Name Information Product Use Citation Customer Product Validation
S1464 Marbofloxacin Marbofloxacin is a potent antibiotic inhibiting bacterial DNA replication.
S2492 Novobiocin Sodium Novobiocin Sodium is an aminocoumarin antibiotic that targets bacterial DNA gyrase (TopoIV), used to treat susceptible gram positive bacteria.
  • Mol Cancer, 2014, 13(1):265
S1756 Enoxacin Enoxacin is an oral broad-spectrum fluoroquinolone antibacterial agent by inhibiting bacterial DNA gyrase and topoisomerase IV, used to treat a wide variety of infections.
S1463 Ofloxacin Ofloxacin is a synthetic broad-spectrum antimicrobial agent.
S1327 Ellagic acid Ellagic acid has antiproliferative and antioxidant property.
  • Int J Nanomedicine, 2015, 10:475-84
S2328 Nalidixic acid Nalidixic acid is a synthetic 1,8-naphthyridine antimicrobial agent with a limited bacteriocidal spectrum. It is an inhibitor of the A subunit of bacterial DNA gyrase.
S1509 Norfloxacin Norfloxacin is a broad-spectrum antibiotic.
S7261 Beta-Lapachone Beta-Lapachone is a selective DNA topoisomerase I inhibitor, exhibiting no inhibitory activities against DNA topoisomerase II or ligase. Phase 2.
S4006 Clinafloxacin Clinafloxacin is a fluoroquinolone that inhibits both DNA gyrase and topoisomerase IV dually in Streptococcus pneumoniae.
S3603 Betulinic acid Betulinic acid, a pentacyclic triterpenoid from Syzigium claviflorum, is a inhibitor of HIV-1 with EC50 of 1.4 μ M. Phase 1/2.
Cat.No. Product Name Information Product Use Citation Customer Product Validation
S4119 Pefloxacin Mesylate Dihydrate Pefloxacin Mesylate Dihydrate is the third generation of fluoroquinolone class of antibacterials, which inhibits Topoisomerase II activity and DNA replication.
S3181 Flumequine Flumequine is a synthetic chemotherapeutic antibiotic, inhibiting topoisomerase II with IC50 of 15 μM.
S7518 Voreloxin (SNS-595) Voreloxin is a potent Topoisomerase II inhibitor with broad-spectrum anti-tumor activity. Phase 2.
S2423 (S)-10-Hydroxycamptothecin 10-Hydroxycamptothecin is a DNA topoisomerase I inhibitor with potent anti-tumor activity.

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Cat.No. Product Name Solubility (25°C)
Water DMSO Ethanol
S1208 Doxorubicin (Adriamycin) 20 mg/mL 100 mg/mL <1 mg/mL
S1225 Etoposide <1 mg/mL 100 mg/mL <1 mg/mL
S1288 Camptothecin <1 mg/mL 3 mg/mL <1 mg/mL
S1231 Topotecan HCl 92 mg/mL 92 mg/mL <1 mg/mL
S1198 Irinotecan <1 mg/mL 7 mg/mL <1 mg/mL
S1228 Idarubicin HCl 7 mg/mL 100 mg/mL <1 mg/mL
S1223 Epirubicin HCl 100 mg/mL 100 mg/mL <1 mg/mL
S2485 Mitoxantrone HCl 89 mg/mL 89 mg/mL <1 mg/mL
S3035 Daunorubicin HCl 100 mg/mL 100 mg/mL <1 mg/mL
S1465 Moxifloxacin HCl <1 mg/mL 88 mg/mL <1 mg/mL
S2217 Irinotecan HCl Trihydrate 1 mg/mL 100 mg/mL 7 mg/mL
S4908 SN-38 <1 mg/mL 21 mg/mL <1 mg/mL
S1367 Amonafide <1 mg/mL 57 mg/mL 4 mg/mL
S1787 Teniposide <1 mg/mL 40 mg/mL <1 mg/mL
S1340 Gatifloxacin <1 mg/mL 7 mg/mL <1 mg/mL
S1342 Genistein <1 mg/mL 54 mg/mL 2 mg/mL
S1889 Mitoxantrone <1 mg/mL 88 mg/mL <1 mg/mL
S1940 Levofloxacin 11 mg/mL 24 mg/mL 9 mg/mL
S1393 Pirarubicin <1 mg/mL 7 mg/mL <1 mg/mL
S2027 Ciprofloxacin <1 mg/mL <1 mg/mL <1 mg/mL
S1464 Marbofloxacin <1 mg/mL 3 mg/mL <1 mg/mL
S2492 Novobiocin Sodium 127 mg/mL 127 mg/mL 127 mg/mL
S1756 Enoxacin <1 mg/mL 32 mg/mL <1 mg/mL
S1463 Ofloxacin <1 mg/mL S1463 mg/mL <1 mg/mL
S1327 Ellagic acid <1 mg/mL 3 mg/mL <1 mg/mL
S2328 Nalidixic acid <1 mg/mL 6 mg/mL <1 mg/mL
S1509 Norfloxacin <1 mg/mL 3 mg/mL <1 mg/mL
S7261 Beta-Lapachone <1 mg/mL 33 mg/mL 10 mg/mL
S4006 Clinafloxacin <1 mg/mL 0.03 mg/mL <1 mg/mL
S3603 Betulinic acid <1 mg/mL 20 mg/mL 10 mg/mL
S4119 Pefloxacin Mesylate Dihydrate 67 mg/mL 9 mg/mL <1 mg/mL
S3181 Flumequine <1 mg/mL 3 mg/mL <1 mg/mL
S7518 Voreloxin (SNS-595) 1 mg/mL 1 mg/mL <1 mg/mL
S2423 (S)-10-Hydroxycamptothecin <1 mg/mL 8 mg/mL <1 mg/mL
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