Topoisomerase

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Topoisomerase Inhibitors (24)

water-soluble

Cat.No. Product Name Information Product Citations Customer Reviews
S1208 Doxorubicin (Adriamycin) Doxorubicin (Adriamycin) is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis.
  • Nat Commun, 2014, 5:3384
  • Cancer Res, 2014, 74(1):298-308
  • Mol Cancer Ther, 2011, 10(10):1846-56
S1225 Etoposide Etoposide is a semisynthetic derivative of podophyllotoxin, which inhibits DNA synthesis via topoisomerase II inhibition activity.
  • Cancer Res, 2011, 71(13):4707-19
  • Mol Cancer Ther, 2011, 10(10):1846-56
  • BMC Cancer, 2014, 14:483
S1288 Camptothecin Camptothecin is a specific inhibitor of DNA topoisomerase I (Topo I) with IC50 of 0.68 μM. Phase 2.
  • EMBO Rep, 2010, 11(12):962-8
  • PLoS One, 2014, 9(7):e101844
S1231 Topotecan HCl Topotecan (NSC 609699) is a topoisomerase I inhibitor for MCF-7 Luc cells and DU-145 Luc cells with IC50 of 13 nM and 2 nM, respectively.
  • PLoS Genet, 2014, 10(1):e1004107
  • Nat Chem Biol, 2014, 10(9):768-73
  • Universität Göttingen, 2012, Wilko Hinrichs
S1198 Irinotecan Irinotecan is a topoisomerase I inhibitor for LoVo cells and HT-29 cells with IC50 of 15.8 μM and 5.17 μM, respectively.
S7518 Voreloxin (SNS-595) Voreloxin is a potent Topoisomerase II inhibitor with broad-spectrum anti-tumor activity. Phase 2.
S1228 Idarubicin HCl Idarubicin HCl is a hydrochloride salt form of Idarubicin which is an anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells with IC50 of 3.3 ng/mL.
  • Mol Cancer Ther, 2013, 12(7):1299-309
  • Nat Chem Biol, 2014, 10(9):768-73
  • J Phys Chem B, 2013, 117(23):6868-73
S1223 Epirubicin HCl Epirubicin HCl, a semisynthetic L-arabino derivative of doxorubicin, is an antineoplastic agent by inhibiting Topoisomerase.
S2485 Mitoxantrone HCl Mitoxantrone is a type II topoisomerase inhibitor with IC50 of 2.0 μM, 0.42 mM for HepG2 and MCF-7/wt cells, respectively.
S1465 Moxifloxacin HCl Moxifloxacin is a fourth-generation synthetic fluoroquinolone antibacterial agent.
  • Sci Rep, 2013, 3:2101
Cat.No. Product Name Information Product Citations Customer Reviews
S2217 Irinotecan HCl Trihydrate Irinotecan prevents DNA from unwinding by inhibition of topoisomerase 1.
S4908 SN-38 SN-38 is an active metabolite of CPT-11, inhibits DNA topoisomerase I, DNA synthesis and causes frequent DNA single-strand breaks.
  • J Pharmacol Exp Ther, 2014, 348(3):432-41
S1367 Amonafide Amonafide produces protein-associated DNA-strand breaks through a topoisomerase II-mediated reaction, but does not produce topoisomerase I-mediated DNA cleavage. Phase 3.
S1340 Gatifloxacin Gatifloxacin is an antibiotic of the fourth-generation fluoroquinolone family, and inhibits the bacterial enzymes DNA gyrase and topoisomerase IV.
S1342 Genistein Genistein, a phytoestrogen found in soy products, is a highly specific inhibitor of protein tyrosine kinase (PTK) which blocks the mitogenic effect mediated by EGF on NIH-3T3 cells with IC50 of 12μM or by insulin with IC50 of 19 μM.
S1889 Mitoxantrone Mitoxantrone is a type II topoisomerase inhibitor with IC50 of 2.0 μM, 0.42 mM for HepG2 and MCF-7/wt cells, respectively
S1393 Pirarubicin Pirarubicin is an anthracycline antibiotic, and also a DNA/RNA synthesis inhibitor by intercalating into DNA and interacts with topoisomerase II, used as an antineoplastic agent.
S1463 Ofloxacin Ofloxacin is a synthetic broad-spectrum antimicrobial agent.
S1327 Ellagic acid Ellagic acid has antiproliferative and antioxidant property.
S7261 Beta-Lapachone Beta-Lapachone is a selective DNA topoisomerase I inhibitor, exhibiting no inhibitory activities against DNA topoisomerase II or ligase. Phase 2.
Cat.No. Product Name Information Product Citations Customer Reviews
S3603 Betulinic acid Betulinic acid, a pentacyclic triterpenoid from Syzigium claviflorum, is a inhibitor of HIV-1 with EC50 of 1.4 μ M. Phase 1/2.
S4119 Pefloxacin Mesylate Dihydrate Pefloxacin Mesylate Dihydrate is the third generation of fluoroquinolone class of antibacterials, which inhibits Topoisomerase II activity and DNA replication.
S3181 Flumequine Flumequine is a synthetic chemotherapeutic antibiotic, inhibiting topoisomerase II with IC50 of 15 μM.
S2423 (S)-10-Hydroxycamptothecin 10-Hydroxycamptothecin is a DNA topoisomerase I inhibitor with potent anti-tumor activity.
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