• Compare Topoisomerase Products
  • Research Area

Topoisomerase Inhibitors (34)


Cat.No. Product Name Information Product Use Citation Customer Product Validation
S1208 Doxorubicin (Adriamycin) Doxorubicin (Adriamycin) is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis.
  • Nat Commun, 2014, 5:3384
  • Cancer Res, 2014, 74(1):298-308
  • Oncogene, 2015, 10.1038/onc.2014.443
S1225 Etoposide Etoposide is a semisynthetic derivative of podophyllotoxin, which inhibits DNA synthesis via topoisomerase II inhibition activity.
  • Cancer Res, 2011, 71(13):4707-19
  • Mol Cancer Ther, 2011, 10(10):1846-56
  • BMC Cancer, 2014, 14:483
S1288 Camptothecin Camptothecin is a specific inhibitor of DNA topoisomerase I (Topo I) with IC50 of 0.68 μM. Phase 2.
  • EMBO Rep, 2010, 11(12):962-8
  • PLoS One, 2014, 9(7):e101844
S1231 Topotecan HCl Topotecan (NSC 609699) is a topoisomerase I inhibitor for MCF-7 Luc cells and DU-145 Luc cells with IC50 of 13 nM and 2 nM, respectively.
  • PLoS Genet, 2014, 10(1):e1004107
  • Nat Chem Biol, 2014, 10(9):768-73
  • Universität Göttingen, 2012, Wilko Hinrichs
S1198 Irinotecan Irinotecan is a topoisomerase I inhibitor for LoVo cells and HT-29 cells with IC50 of 15.8 μM and 5.17 μM, respectively.
S7518 Voreloxin (SNS-595) Voreloxin is a potent Topoisomerase II inhibitor with broad-spectrum anti-tumor activity. Phase 2.
S1228 Idarubicin HCl Idarubicin HCl is a hydrochloride salt form of Idarubicin which is an anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells with IC50 of 3.3 ng/mL.
  • Mol Cancer Ther, 2013, 12(7):1299-309
  • Nat Chem Biol, 2014, 10(9):768-73
  • J Phys Chem B, 2013, 117(23):6868-73
S1223 Epirubicin HCl Epirubicin HCl, a semisynthetic L-arabino derivative of doxorubicin, is an antineoplastic agent by inhibiting Topoisomerase.
S2485 Mitoxantrone HCl Mitoxantrone is a type II topoisomerase inhibitor with IC50 of 2.0 μM, 0.42 mM for HepG2 and MCF-7/wt cells, respectively.
S3035 Daunorubicin HCl Daunorubicin HCl inhibits both DNA and RNA synthesis and inhibits DNA synthesis with Ki of 0.02 μM.
  • J Phys Chem B, 2013, 117(23):6868-73
Cat.No. Product Name Information Product Use Citation Customer Product Validation
S1465 Moxifloxacin HCl Moxifloxacin is a fourth-generation synthetic fluoroquinolone antibacterial agent.
  • Sci Rep, 2013, 3:2101
S2217 Irinotecan HCl Trihydrate Irinotecan prevents DNA from unwinding by inhibition of topoisomerase 1.
S4908 SN-38 SN-38 is an active metabolite of CPT-11, inhibits DNA topoisomerase I, DNA synthesis and causes frequent DNA single-strand breaks.
  • J Pharmacol Exp Ther, 2014, 348(3):432-41
  • J Am Soc Mass Spectrom, 26(4):577-86,
S1367 Amonafide Amonafide produces protein-associated DNA-strand breaks through a topoisomerase II-mediated reaction, but does not produce topoisomerase I-mediated DNA cleavage. Phase 3.
  • Theranostics, 2015, 5(5): 477-488
S1787 Teniposide Teniposide is a chemotherapeutic medication mainly used in the treatment of childhood acute lymphocytic leukemia (ALL).
S1340 Gatifloxacin Gatifloxacin is an antibiotic of the fourth-generation fluoroquinolone family, and inhibits the bacterial enzymes DNA gyrase and topoisomerase IV.
S1342 Genistein Genistein, a phytoestrogen found in soy products, is a highly specific inhibitor of protein tyrosine kinase (PTK) which blocks the mitogenic effect mediated by EGF on NIH-3T3 cells with IC50 of 12μM or by insulin with IC50 of 19 μM.
S1889 Mitoxantrone Mitoxantrone is a type II topoisomerase inhibitor with IC50 of 2.0 μM, 0.42 mM for HepG2 and MCF-7/wt cells, respectively
  • Electrochimica Acta, 2015, 10.1016/j.electacta.2015.02.223
S1940 Levofloxacin Levofloxacin is a broad-spectrum antibiotic topoisomerase II and topoisomerase IV inhibitor, used to treat respiratory, urinary tract, gastrointestinal, and abdominal infections.
S1393 Pirarubicin Pirarubicin is an anthracycline antibiotic, and also a DNA/RNA synthesis inhibitor by intercalating into DNA and interacts with topoisomerase II, used as an antineoplastic agent.
Cat.No. Product Name Information Product Use Citation Customer Product Validation
S2027 Ciprofloxacin Ciprofloxacin is a fluoroquinolone antibiotic, shows broad and potent antibacterial activity, with MIC90 of 0.024-6 μM.
  • Cancer Res, 2012, 72(23):6200-8
S1464 Marbofloxacin Marbofloxacin is a potent antibiotic inhibiting bacterial DNA replication.
S2492 Novobiocin Sodium Novobiocin Sodium is a very potent bacterial DNA gyrase and human organic anion transporters with Ki of 14.87 ± 0.40 μM for hOAT1, 4.77 ± 1.12 μM for hOAT3 and 90.50 ± 7.50 μM for hOAT4.
  • Mol Cancer, 2014, 13(1):265
  • Mol Cancer, 2014, 13(1):265
S1756 Enoxacin Enoxacin is an oral broad-spectrum fluoroquinolone antibacterial agent used in the treatment of urinary tract infections and gonorrhea. Insomnia is a common adverse effect.
S1463 Ofloxacin Ofloxacin is a synthetic broad-spectrum antimicrobial agent.
S1327 Ellagic acid Ellagic acid has antiproliferative and antioxidant property.
  • Int J Nanomedicine, 2015, 10:475-84
S2328 Nalidixic acid Nalidixic acid is a synthetic 1,8-naphthyridine antimicrobial agent with a limited bacteriocidal spectrum. It is an inhibitor of the A subunit of bacterial DNA gyrase.
S1509 Norfloxacin Norfloxacin is a broad-spectrum antibiotic.
S7261 Beta-Lapachone Beta-Lapachone is a selective DNA topoisomerase I inhibitor, exhibiting no inhibitory activities against DNA topoisomerase II or ligase. Phase 2.
S4006 Clinafloxacin Clinafloxacin is a fluoroquinolone that inhibits both DNA gyrase and topoisomerase IV dually in Streptococcus pneumoniae.
Cat.No. Product Name Information Product Use Citation Customer Product Validation
S3603 Betulinic acid Betulinic acid, a pentacyclic triterpenoid from Syzigium claviflorum, is a inhibitor of HIV-1 with EC50 of 1.4 μ M. Phase 1/2.
S4119 Pefloxacin Mesylate Dihydrate Pefloxacin Mesylate Dihydrate is the third generation of fluoroquinolone class of antibacterials, which inhibits Topoisomerase II activity and DNA replication.
S3181 Flumequine Flumequine is a synthetic chemotherapeutic antibiotic, inhibiting topoisomerase II with IC50 of 15 μM.
S2423 (S)-10-Hydroxycamptothecin 10-Hydroxycamptothecin is a DNA topoisomerase I inhibitor with potent anti-tumor activity.

Hover Mouse over '+' to display IC50

Contact Us