Research Area
Product Type
United States ( Change Country )
Etoposide (VP-16) Chemical Structure
Recommended Products
Irinotecan
Irinotecan is a topoisomerase I inhibitor with an IC50 of 15.8 and 5.17 μM for LoVo cells and HT-29 cells, respectively.
Adriamycin (Doxorubicin)
Adriamycin (Doxorubicin) is a topoisomerase II inhibitor with IC50 of 1 and 2 μM for the inhibition of MCF-7 and MDA-MB231.
Cerubidine (Daunorubicin HCl, Rubidomycin HCl)
Cerubidine (Daunorubicin HCl, Rubidomycin HCl) is the hydrochloride salt of an anthracycline cytotoxic antibiotic produced by a strain of Streptomyces coeruleorubidus (IC50=0.5μM).
Epirubicin Hydrochloride
Epirubicin Hydrochloride (Ellence) is an anthracyclin antibiotics and a DNA topoisomerase II inhibitor with an IC50 of 12 μg/ml on an estrogen-receptor- positive ER (+) hyperdiploid EAT cell line.
Idarubicin HCl
Idarubicin is the anthracycline antibiotic and target DNA topoisomerase II (topo II). MCF-7 cells were sensitive to idarubicin, with an IC 50 value for growth inhibition of 0.01 μM
Topotecan HCl
Topotecan Hydrochloride is a topoisomerase I inhibitor with an IC50 of 13 and 2 nM for MCF-7 Luc cells and DU-145 Luc cells.
Camptothecin
Camptothecin is a cytotoxic quinoline alkaloid which inhibits the DNA enzyme topoisomerase I (topo I) with an IC50 and IC70 of 50 nM and 0. 225 μM .
Amonafide
Amonafide is a drug used in the treatment of cancer.
Moxifloxacin hydrochloride
Moxifloxacin(Avelox, Avalox) is a fourth generation synthetic fluoroquinolone antibacterial agent.
Irinotecan HCl Trihydrate (Campto)
Irinotecan hydrochloride trihydrate is a hydrochloride trihydrate of irinotecan (Camptosar, Campto, CPT-11) which is a topoisomerase I inhibitor with IC50 of 15.8 and 5.17 μM for LoVo cells and HT-29 cells, respectively.
Biological Activity
Two subclones of the OCI/AML-2 cell line, etoposide-sensitive (ES) and etoposide-resistant (ER) were used to investigate whether the Fas pathway is involved in etoposide-induced apoptosis in acute myeloblastic leukemia (AML). Both of the studied subclones expressed the Fas receptor (FasR), but only the ER cell line expressed the Fas ligand (FasL). Etoposide caused an increase in the mean fluorescence intensity of FasR in both subclones, and an induction of FasL in the ES subclone. However, no change in the numbers of apoptotic cells induced by etoposide was observed when FasR was blocked by an antagonist anti-Fas antibody, nor was an agonist anti-Fas antibody alone cytotoxic to the subclones or enhanced the cytotoxic effect of etoposide. [1]
Etoposide phosphate is rapidly absorbed and converted to etoposide. Bioavailability averages 68% at doses up to 150 mg/m2/day. [3]
Chemical Information
| Molecular Weight (WM): | 588.56 |
|---|---|
| Formula: | C29H32O13 |
| CAS No.: | 33419-42-0 |
| Synonyms: |
Vepesid
|
| Dissolve in (25°C): | DMSO ≥118mg/mL |
| Water <1mg/mL | |
| Ethanol <1mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
Quality Control & MSDS
Research Area
Notes:
Related Inhibitors
Recommended Screening Libraries
Chemical Library
A collection of 864 bioactive compounds
Inhibitor Library
A collection of 481 inhibitors
Kinase Inhibitor Library
A collection of 194 kinase inhibitors
Tyrosine Kinase Inhibitor Library
A collection of 85 tyrosine kinase inhibitors.
FDA Approved Drug Library
A collection of 426 FDA approved drugs
Natural Product Library
A collection of 139 natural products
Chemotherapeutic Agent Library
A collection of 40 chemotherapeutic agents
Epigenetics Compound library
A unique collection of 17 small molecule modulators
Stem Cell Compound library
A unique collection of 47 small molecule inhibitors
GPCR Compound library
A unique collection of 63 GPCR small molecules
Selleck's high quality products have been used in several published research findings, including the following:
An integrated chemical biology approach identifies specific vulnerability of Ewing's sarcoma to combined inhibition of Aurora kinases A and B
We have 1 customer reviews of Etoposide (VP-16).
- (0)
- (1)
- (0)
- (0)
- (0)
- (0)
- (0)
- (0)
- (0)
Average Customer Review
(1 customer reviews)
-
Click to enlarge
Tozasertib is more effective in comparison to- and shows synergistic potential with etoposide and doxorubicin. (A) Dose-response curves of tozasertib, doxorubicin and etoposide in SK-ES-1 and A673.
Tozasertib is more effective in comparison to- and shows synergistic potential with etoposide and doxorubicin. (A) Dose-response curves of tozasertib, doxorubicin and etoposide in SK-ES-1 and A673.
Data from [Mol Cancer Ther 2011 October;10:1846-56] Etoposide (VP-16) purchased from Selleck
This product has been referenced in
Check our customer reviews
Tozasertib is more effective in comparison to- and shows synergistic potential with etoposide and doxorubicin. (A) Dose-response curves of tozasertib, doxorubicin and etoposide in SK-ES-1 and A673. |
Data from [Mol Cancer Ther 2011 October;10:1846-56]
We give free samples and rewards to people who would like to provide us useful scientific data(western blot, etc.) > See Details
Recently Viewed Items
Keywords:buy Etoposide (VP-16) | Etoposide (VP-16) supplier | purchase Etoposide (VP-16) | Etoposide (VP-16) cost | Etoposide (VP-16) manufacturer | order Etoposide (VP-16) | Etoposide (VP-16) distributor