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Pirarubicin is available in the following compound libraries:

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Dr. Antonino Maria Sparta demonstrates a breakthrough in leukemia research by utilizing two inhibitors produced by Selleck Chemicals.

Cat.No.	Product Name	Solubility (25°C)
S1208	Doxorubicin (Adriamycin)	20 mg/mL	109 mg/mL	<1 mg/mL
S1225	Etoposide (VP-16)	<1 mg/mL	100 mg/mL	<1 mg/mL
S1231	Topotecan HCl	92 mg/mL	92 mg/mL	<1 mg/mL
S1288	Camptothecin	<1 mg/mL	3 mg/mL	<1 mg/mL
S1198	Irinotecan	<1 mg/mL	10 mg/mL	<1 mg/mL
S1223	Epirubicin HCl	116 mg/mL	116 mg/mL	3 mg/mL
S2217	Irinotecan HCl Trihydrate (Campto)	2 mg/mL	135 mg/mL	7 mg/mL
S1228	Idarubicin HCl	10 mg/mL	107 mg/mL	<1 mg/mL
S1465	Moxifloxacin HCl	<1 mg/mL	88 mg/mL	<1 mg/mL
S1367	Amonafide	<1 mg/mL	57 mg/mL	4 mg/mL
S1393	Pirarubicin	<1 mg/mL	126 mg/mL	<1 mg/mL
S1327	Ellagic acid	<1 mg/mL	<1 mg/mL	<1 mg/mL
S1342	Genistein	<1 mg/mL	54 mg/mL	2 mg/mL
S1463	Ofloxacin (Floxin)	<1 mg/mL	0.4 mg/mL	<1 mg/mL
S1889	Mitoxantrone	89 mg/mL	89 mg/mL	<1 mg/mL
S3181	Flumequine	<1 mg/mL	3 mg/mL	<1 mg/mL

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Biological Activity Chemical Information Tech Support & FAQs

Biological Activity

Pirarubicin is an anthracycline drug. An analogue of the anthracycline antineoplastic antibiotic doxorubicin. Pirarubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. This agent is less cardiotoxic than doxorubicin and exhibits activity against some doxorubicin-resistant cell lines. ^[1,2]

Chemical Information

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Molecular Weight (MW)	627.64
Formula	C₃₂H₃₇NO₁₂
CAS No.	72496-41-4, 95343-20-7 (HCl)
Synonyms	THP-Adriamycin

Solubility (25°C) DMSO 126 mg/mL Water <1 mg/mL Ethanol <1 mg/mL
Storage	2 years -20°CPowder
	2 weeks4°Cin DMSO
	6 months-80°Cin DMSO

Chemical Name	(7S,9S)-7-((2R,4S,5S,6S)-4-amino-6-methyl-5-((R)-tetrahydro-2H-pyran-2-yloxy)-tetrahydro-2H-pyran-2-yloxy)-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3Monday–Friday 9:00 AM–5:00 PM (Central Time)

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Related Topoisomerase Inhibitors

Camptothecin
Camptothecin (Camptohecine, 20-(S)-Camptothecin, CPT, NSC100880) is a specific inhibitor of DNA topoisomerase I (Topo I) with IC50 of 0.68 μM.
Amonafide
Amonafide (NSC-308847) is a selective topoisomerase II inhibitor.
SN-38
SN-38 is an active metabolite of CPT-11 that inhibits DNA topoisomerase I.
ABT-888 (Veliparib)

ABT-888 (Veliparib, NSC 737664) is a potent inhibitor of PARP1 and PARP2 with K_i of 5.2 nM and 2.9 nM, respectively.
Olaparib (AZD2281)

Olaparib (AZD2281, KU0059436) is a selective inhibitor of PARP1 and PARP2 with IC50 of 5 nM and 1 nM, respectively.
Iniparib (BSI-201)

BSI-201 (Iniparib, SAR240550) is a PARP1 inhibitor.
KU-55933

KU-55933 is a potent and specific ATM inhibitor with IC50 and K_i of 13 nM and 2.2 nM, respectively.
Rucaparib (AG-014699 , PF-01367338)

Rucaparib (AG-014699, PF-01367338) is an inhibitor of PARP with K_i of 1.4 nM.
INO-1001
INO-1001 is a potent inhibitor of PARP with IC50 of 50 nM and a mediator of oxidant-induced myocyte dysfunction during reperfusion.
BIBR 1532
BIBR 1532 is a potent and selective telomerase inhibitor with IC50 of 100 nM.

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Pirarubicin

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Related Compound Libraries

Pirarubicin is available in the following compound libraries:

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Cat.No.	Product Name	Solubility (25°C)
Cat.No.	Product Name	Water	DMSO	Ethanol
S1208	Doxorubicin (Adriamycin)	20 mg/mL	109 mg/mL	<1 mg/mL
S1225	Etoposide (VP-16)	<1 mg/mL	100 mg/mL	<1 mg/mL
S1231	Topotecan HCl	92 mg/mL	92 mg/mL	<1 mg/mL
S1288	Camptothecin	<1 mg/mL	3 mg/mL	<1 mg/mL
S1198	Irinotecan	<1 mg/mL	10 mg/mL	<1 mg/mL
S1223	Epirubicin HCl	116 mg/mL	116 mg/mL	3 mg/mL
S2217	Irinotecan HCl Trihydrate (Campto)	2 mg/mL	135 mg/mL	7 mg/mL
S1228	Idarubicin HCl	10 mg/mL	107 mg/mL	<1 mg/mL
S1465	Moxifloxacin HCl	<1 mg/mL	88 mg/mL	<1 mg/mL
S1367	Amonafide	<1 mg/mL	57 mg/mL	4 mg/mL
S1393	Pirarubicin	<1 mg/mL	126 mg/mL	<1 mg/mL
S1327	Ellagic acid	<1 mg/mL	<1 mg/mL	<1 mg/mL
S1342	Genistein	<1 mg/mL	54 mg/mL	2 mg/mL
S1463	Ofloxacin (Floxin)	<1 mg/mL	0.4 mg/mL	<1 mg/mL
S1889	Mitoxantrone	89 mg/mL	89 mg/mL	<1 mg/mL
S3181	Flumequine	<1 mg/mL	3 mg/mL	<1 mg/mL

Choose Your Country or Region

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Pirarubicin

Validation & Quality Control

Quality Control & MSDS

Related Compound Libraries

Pirarubicin is available in the following compound libraries:

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Chemical Information

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