Research Area
Product Type
United States ( Change Country )
Amonafide Chemical Structure
Irinotecan
Irinotecan is a topoisomerase I inhibitor with an IC50 of 15.8 and 5.17 μM for LoVo cells and HT-29 cells, respectively.
Adriamycin (Doxorubicin)
Adriamycin (Doxorubicin) is a topoisomerase II inhibitor with IC50 of 1 and 2 μM for the inhibition of MCF-7 and MDA-MB231.
Cerubidine (Daunorubicin HCl, Rubidomycin HCl)
Cerubidine (Daunorubicin HCl, Rubidomycin HCl) is the hydrochloride salt of an anthracycline cytotoxic antibiotic produced by a strain of Streptomyces coeruleorubidus (IC50=0.5μM).
Epirubicin Hydrochloride
Epirubicin Hydrochloride (Ellence) is an anthracyclin antibiotics and a DNA topoisomerase II inhibitor with an IC50 of 12 μg/ml on an estrogen-receptor- positive ER (+) hyperdiploid EAT cell line.
Etoposide (VP-16)
Etoposide (VP-16) is a Topoisomerase II inhibitor (IC50 = 59.2 μM).
Idarubicin HCl
Idarubicin is the anthracycline antibiotic and target DNA topoisomerase II (topo II). MCF-7 cells were sensitive to idarubicin, with an IC 50 value for growth inhibition of 0.01 μM
Topotecan HCl
Topotecan Hydrochloride is a topoisomerase I inhibitor with an IC50 of 13 and 2 nM for MCF-7 Luc cells and DU-145 Luc cells.
Camptothecin
Camptothecin is a cytotoxic quinoline alkaloid which inhibits the DNA enzyme topoisomerase I (topo I) with an IC50 and IC70 of 50 nM and 0. 225 μM .
Moxifloxacin hydrochloride
Moxifloxacin(Avelox, Avalox) is a fourth generation synthetic fluoroquinolone antibacterial agent.
Irinotecan HCl Trihydrate (Campto)
Irinotecan hydrochloride trihydrate is a hydrochloride trihydrate of irinotecan (Camptosar, Campto, CPT-11) which is a topoisomerase I inhibitor with IC50 of 15.8 and 5.17 μM for LoVo cells and HT-29 cells, respectively.
Biological Activity
Amonafide is a drug used in the treatment of cancer. It belongs to the families of drugs called topoisomerase inhibitors and DNA intercalators. As of 2008, it is in Phase III clinical trials. In March 2010 it is Phase III trial against secondary acute myeloid leukaemia (AML). [1]
References on Amonafide
- [1] www.bentham.org/prc/samples/prc1-1/Higashi.pdf ;
Product Information
| Molecular Weight (WM): | 283.33 |
|---|---|
| Formula: | C16H17N3O2 |
| CAS No.: | 69408-81-7 |
| Synonyms: |
AS1413, Xanafide, Quinamed
|
| Dissolve in (25°C): | DMSO ≥57mg/mL |
| Water <1mg/mL | |
| Ethanol ≥4mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
Quality Control & MSDS
Research Area
Notes:
Related Inhibitors
Recommended Screening Libraries
Chemical Library
A collection of 864 bioactive compounds
Inhibitor Library
A collection of 481 inhibitors
Kinase Inhibitor Library
A collection of 194 kinase inhibitors
Tyrosine Kinase Inhibitor Library
A collection of 85 tyrosine kinase inhibitors.
FDA Approved Drug Library
A collection of 426 FDA approved drugs
Natural Product Library
A collection of 139 natural products
Chemotherapeutic Agent Library
A collection of 40 chemotherapeutic agents
Epigenetics Compound library
A unique collection of 17 small molecule modulators
Stem Cell Compound library
A unique collection of 47 small molecule inhibitors
GPCR Compound library
A unique collection of 63 GPCR small molecules
Keywords:buy Amonafide | Amonafide supplier | purchase Amonafide | Amonafide cost | Amonafide manufacturer | order Amonafide | Amonafide distributor