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Clinafloxacin Topoisomerase inhibitor

Cat.No.S4006

Clinafloxacin (CI-960, PD127391, AM-1091) is a fluoroquinolone that inhibits both DNA gyrase and topoisomerase IV dually in Streptococcus pneumoniae.
Clinafloxacin Topoisomerase inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 365.79

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Quality Control

Batch: S400601 5%TFA]3.02 mg/mL]false]DMSO]0.03 mg/mL]false]Water]Insoluble]false Purity: 99.09%
99.09

Solubility

In vitro
Batch:

5%TFA : 3.02 mg/mL

DMSO : 0.03 mg/mL (0.08 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

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In vivo
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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Chemical Information, Storage & Stability

Molecular Weight 365.79 Formula

C17H17ClFN3O3

 Storage (From the date of receipt)
CAS No. 105956-97-6 Download SDF Storage of Stock Solutions

Synonyms CI-960, PD127391, AM-1091 Smiles C1CC1N2C=C(C(=O)C3=CC(=C(C(=C32)Cl)N4CCC(C4)N)F)C(=O)O

Mechanism of Action

Targets/IC50/Ki
Topoisomerase IV
DNA gyrase
In vitro
Clinafloxacin is a broad-spectrum antibiotic of the quinolone carboxylic acid category currently in development for intravenous and oral therapy of serious infections. This compound is a novel fluoroquinolone with potent broad-spectrum in vitro activity against gram-positive, gram-negative, and anaerobic pathogens. It is highly active against S. pneumoniae 7785 (MIC, 0.125 μg/mL), and neither gyrA nor parC quinolone resistance mutations alone have much effect on this activity. This agent is identified as the most active fluoroquinolone against S. pneumoniae when compared with ofloxacin, levofloxacin, sparfloxacin, grepafloxacin, and trovafloxacin and is currently being evaluated as an antipneumococcal agent.
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