Doxorubicin (Adriamycin)

Licensed by Pfizer Catalog No.S1208 Synonyms: NSC 123127

Doxorubicin (Adriamycin) Chemical Structure

Molecular Weight(MW): 579.98

Doxorubicin (Adriamycin) is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis in tumor cells.

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Cited by 31 Publications

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  • Enhancement of apoptotic response by addition of targeted agents lapatinib and sunitinib to doxorubicin in the same device reservoir at 24 hours. P values were determined using Student’s t test for all graphs.

    Sci Transl Med, 2015, 7(284): 284ra57 . Doxorubicin (Adriamycin) purchased from Selleck.

    Cell viabilities with increasing concentrations of cisplatin (CP) and doxorubicin (DOXO) under normoxic and hypoxic condition for 48 hours were determined by MTT assay. IC50 values are presented as the means ?SDs (n=4) and * denotes p<0.05.

    Cancer Res 2014 74, 298-308. Doxorubicin (Adriamycin) purchased from Selleck.

  • Cleavage of caspase-3, -9 and the expression of PARP were measured by western blot using b-actin as a loading control.

    Cell Cycle, 2017.. Doxorubicin (Adriamycin) purchased from Selleck.

    (C) & (D) Treatments with doxorubicin, cisplatin or AZD6244 further decreased the cell viability in RH30 cloned cells in which STAT3 or GP130 was knockdown by shRNA. (*P<.05, ** P <.01, *** P <.001).

    Curr Cancer Drug Targets, 2016, 16(7):631-8. Doxorubicin (Adriamycin) purchased from Selleck.

  •  

    Doxorubicin release of P(MAA-g-EG) and P(MAA-g-EG) containing nanoparticles in two-step pH conditions. Doxorubicinloaded P(MAA-g-EG) ,P(MAA-g-EG)-1.0NP ,P(MAA-g-EG)-2.5NP, and P(MAA-g-EG)-5.0NP crushed particles (75–150 um) were released in 1 PBS (pH 2.0) for 90 min. Then the pH was increased to 7.0 by adding 5N NaOH and release continued for 6 h.

    J Biomed Mater Res Part A 2012 10.1002/jbm.a.34064. Doxorubicin (Adriamycin) purchased from Selleck.

    Temporal uptake of free DOX or DOX-PCL63-b-PNVP90 micelles into K-562 (I) and DL (J) cells were studied by incubating in 24-well plates at a concentration of 50,000 cells per well. Representative images shown were obtained using a fluorescence microscope Eclipse 80i (Nikon, Japan) (Plan Fluor, 40X, NA 0.75 objective) equipped with blue and red filters for, Hoechst and Doxorubicin respectively (n = 3).

    PLoS One 2014 9, e94309. Doxorubicin (Adriamycin) purchased from Selleck.

  • PLoS One 2013 8(1), e54595. Doxorubicin (Adriamycin) purchased from Selleck.

    CON+ -positive control (with FBS as chemoattractant); CON- - negative control (without chemoattractant); DOX -doxorubicin; WZ -WZ811; PF- PF-573228; * -significant difference compared to positive control: p<0.05; ** -significant difference compared to positive control: p<0.01; # -significant difference between combination and inhibitor only: p<0.05. Cancer cell invasion was analyzed using Transwell membranes assembled in 24-well plates and covered with a layer of Matrigel. COR-L23 cells were treated for 24 h with 50 nM DOX, 10 uM WZ811, 5 uM PF-573228 and combinations of inhibitors with 50 nM DOX. Similarly, RH460 cells were treated for 24 h with 1 uM DOX, 10 uM WZ811, 2.5 uM PF-573228 and combinations of inhibitors with 1 uM DOX. Applied doses were the ones that exerted the most pronounced synergistic effect on cytotoxicity level. After the incubation period, cells that invaded through matrigel and membranes were fixed in 4% paraformaldehyde-PBS and stained with Hoechst 33342 nuclear stain. Cells were visualized and counted under a fluorescent microscope at 10x magnification.

    2014 Dr Milica Pesic from Institute for Biological Research. Doxorubicin (Adriamycin) purchased from Selleck.

Purity & Quality Control

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Notes:

2. For more details, such as half maximal inhibitory concentrations (IC50s) and working concentrations of each inhibitor, please click on the link of the inhibitor of interest.
3. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
4. Orange "√" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

Biological Activity

Description Doxorubicin (Adriamycin) is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis in tumor cells.
Targets
Topo II [1]
(Tumor cells)
In vitro

Doxorubicin, an antibiotic anthracycline, is commonly considered to exert its anti-tumor activity at two fundamental levels, altering DNA and producing free radicals to trigger apoptosis of cancer cells through DNA damage. Doxorubicin can block the synthesis of DNA by intercalating into the DNA strand, and inhibits DNA topoisomerase II (TOP2). Doxorubicin is most effective when cells are rapidly proliferating and expressing high levels of TOP2. Additionally, Doxorubicin can trigger apoptosis by producing ceramide (which prompts apoptosis by activating p53 or other downstream pathways such as JNK), the degradation of Akt by serine threonine proteases, the mitochondrial release of cytochrome c, increased FasL (death receptor Fas/CD95 ligand) mRNA production, and a greater production of free radicals. [2] Pre-treatment with GSNO (nitrosoglutathione) suppresses the resistance in the doxorubicin-resistant breast cancer cell line MCF7/Dx, accompanied by enhanced protein glutathionylation and accumulation of doxorubicin in the nucleus. [3] Doxorubicin induced G2/M checkpoint arrest are attributed to elevated cyclin G2 (CycG2) expression and phospho-modification of proteins in the ataxia telangiectasia mutated (ATM) and ATM and Rad3-related (ATR) signaling pathways. [5] Doxorubicin inhibits AMP-activated protein kinase (AMPK), resulting in SIRT1 dysfunction, p53 accumulation, and increased cell death in mouse embryonic fibroblasts (MEFs) and cardiomyocytes, which can be further sensitized by pre-inhibition of AMPK. [6] Doxorubicin elicits a marked heat shock response, and that either inhibition or silencing of heat shock proteins enhance the Doxorubicin apoptotic effect in neuroblastoma cells. Nanomolar Doxorubicin treatment of neuroblastoma cells causes dose-dependent over-ubiquitination of a specific set of proteins in the absence of measurable inhibition of proteasome, and loss of activity of ubiquitinated enzymes such as lactate dehydrogenase and α-enolase, the protein ubiquination patterns of which is similar to those with proteasome inhibitor Bortezomib, indicating that Doxorubicin may also exert its effect by damaging proteins. [8]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
L1210 MlnNSpVv[3Srb36gRZN{[Xl? NVG4bFRmUW6qaXLpeIlwdiCxZjDSUmEhe3mwdHjld4l{KHerdHigSWQ2OCCxZjCwMlU5KM7:TR?= M4PmeVQ6ODV|Nh?=
Yoshida sarcoma MmO3SpVv[3Srb36gRZN{[Xl? MkH1TY5pcWKrdHnvckBw\iCdM1jdWIRTKGmwY3;ydI9z[XSrb36ge4l1cCCLQ{WwJI9nKDBwMEKg{txO NWjicIw5OTN{Mkm4Oi=>
CHO M1vtd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWHJR|UxRTBwME[g{txO NID2[4kyOzV2N{Ww
8226 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2D3eGlEPTB;MD6wN|Mh|ryP M2jteFE1PDd5M{C=
8226/ADR MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3HySmlEPTB;MD61OkDPxE1? MnG0NVQ1Pzd|MB?=
MCF7/ADR MkjXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHP6O3lKSzVyPUOuNUDPxE1? Mn:4NVQ1Pzd|MB?=
H69 M2\hcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIDxToxKSzVyPUCuPFch|ryP NGrnfnAyPDd7NUi1
N417 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVzTdHV2UUN3ME2wMlI{KM7:TR?= NEHLWJYyPDd7NUi1
H9 NEPZb3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1jjUmlvcGmkaYTpc44hd2ZiSEmgZ4VtdHNiY3jyc45q[2GubImgbY5n\WO2ZXSge4l1cCC2aHWgTGlXNTFiKFi5M2lKUUJrIIfpeIghUUR3MDDv[kAxNjBzIN88US=> MYixOVQ5Pjhz
T-C8166 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVT2OplsUUR3ME2wMlAyKM7:TR?= M2CwRlE2PDh4OEG=
T-H9 MkDjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1jtNWlFPTB;MD6wNUDPxE1? MlPCNVU1QDZ6MR?=
T-MT4 Mn7NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJSFUxRTBwMEGg{txO MUexOVQ5Pjhz
SKMEL-5 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\KbIlGTDVyPUOuNkDPxE1? M1jTUFE3OTN5NUO=
MLM M130eGN6fG:2b4jpZ{BCe3OjeR?= Mon5SWQ2OD1yLkGzJO69VQ>? M3i0O|E5PzV|NUC=
KBM-3 MmXqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;veWZKSzVyPUCuNFI3KM7:TR?= M37m[FE6QTV6N{e=
HT-29 NYqwe2tWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXHDPHZSOC5yMTFOwIc> NITGfVQ1QCCq NUW4SYVUSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJk> M1rLTFI4Pzh2NEm=
EMT6 NF\4RXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWqwMlUh|ryP MXKxJIg> MY\Jcohq[mm2aX;uJI9nKHC{b3zp[oVz[XSrb36gZpkhdWWjc4XybY5oKG[xcjDzeZJ3cX[rbneg[pJi[3Srb37zJJdqfGhiRVS1NEBw\iByLkCwNFEh|ryP NH:4VWc4PDV{Nke0
H2981 NWXWcmZoS3m2b4TvfIlkKEG|c3H5 MoTNTWM2OD1yLkWg{txO NIHGTXc4PzNzMEKz
LOX M3v1[mN6fG:2b4jpZ{BCe3OjeR?= MVfJR|UxRTBwMESyJO69VQ>? NFf4dIM4QDV|M{Ox
C38 M3XPO2N6fG:2b4jpZ{BCe3OjeR?= NIrF[mZKSzVyPUCuNFEh|ryP Mmj6PFA2PzJ7MR?=
EAC NHPTeXBEgXSxdH;4bYMhSXO|YYm= NUHGcnFSPzJiaB?= M2DvWWlEPTB;MD6zOUDPxE1? M{\TXFg{PTByOEe=
SKVLB M1fab2N6fG:2b4jpZ{BCe3OjeR?= M2j2d2lEPTB;NT62JO69VQ>? MnO5PFU4PjlzNB?=
AUC375 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWnVU4d5UUN3ME2wMlEyOiEQvF2= NUL6Z3ZuQDZ2OE[wNC=>
A2780-C25 MXrDfZRwfG:6aXOgRZN{[Xl? M2HmfmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KG:6YXzpdIxifGmwLYLld4l{fGGwdDDBNlc5OC2FMkWge4l1cCCLQ{WwJI9nKDBwME[zJO69VQ>? NX3j[m17QDh|MUe1OS=>
A2780-CP3 Mk\nR5l1d3SxeHnjJGF{e2G7 M1;YOWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGOrc4DsZZRqdi2{ZYPpd5RidnRiQUK3PFAuS1B|IIfpeIghUUN3MDDv[kAxNjB3NjFOwG0> NX;0U|BSQDh|MUe1OS=>
A2780-DX5 MUfDfZRwfG:6aXOgRZN{[Xl? NHT2NGFEgXSxdH;4bYNqfHliYXfhbY5{fCCmb4jvdpVjcWOrbj3y[ZNqe3SjboSgRVI4QDBvRGi1JJdqfGhiSVO1NEBw\iByLkO1O{DPxE1? NEjZNGU5QDNzN{W1
MXF7 M1P3OmN6fG:2b4jpZ{BCe3OjeR?= M2D5VGFvfGm2dX3vdkBi[3Srdnn0fUBi\2GrboP0JJNmdnOrdHn2[UBOYEZ5IIfpeIghUUN3MDDv[kAxNjB{ODFOwG0> MVi4PVYxPTV6
MXF7 MWDDfZRwfG:6aXOgRZN{[Xl? MmLWRY51cXS3bX;yJIFkfGm4aYT5JIFo[Wmwc4SgcYl1d3ijboTyc45mNXKnc3nzeIFvfCCPWF[3JJdqfGhiSVO1NEBw\iByLkCyPEDPxE1? M4rkUVg6PjB3NUi=
MXF7 NX\6ZoRCS3m2b4TvfIlkKEG|c3H5 NHvMdIRCdnSrdIXtc5Ih[WO2aY\peJkh[WejaX7zeEBld3ixcoXibYNqdi2{ZYPpd5RidnRiTWjGO{B4cXSqIFnDOVAhd2ZiMT6xO|Ih|ryP NFzkdXc5QTZyNUW4
WiDr M4G0TmN6fG:2b4jpZ{BCe3OjeR?= NYDUcplMSWO2aY\peJkh[WejaX7zeEB{\W6|aYTpeoUhX2mGcjDj[YxtKHerdHigTWM2OCCxZjCwMlA2OyEQvF2= NYfYfJJJQDl4MEW1PC=>
MCF NYG4dmhmTnWwY4Tpc44hSXO|YYm= NHrjdXVT\X[ncoPhcEBw\iCSLXfwMY1m\GmjdHXkJI12dHSrZIL1[{Bz\XOrc4ThcoNmKGG|c3Xzd4VlKGG|IHXubIFv[2WvZX70JIlvKGO7dH;0c5hq[2m2eTDv[kBi\HKrYX35Z4lv NWPHfIpYQDl6NEG1NS=>
C6 MmTWR5l1d3SxeHnjJGF{e2G7 MmTpNk42KG2pL33M MnXZO|IhcA>? NEXJXpdFVVOR NX2wRZJKS3m2b4TvfIlkcXS7IHHnZYlve3RicnH0JGM3KGOnbHzzJIF1KDVyIIXnM41NKHSxIEKuOUBu\y:vTB?= MWG4PVg5PjB2
C6 M1ToNGZ2dmO2aX;uJGF{e2G7 M1v3O|IvPSCvZz;tUC=> MlTFOEBp MoPISG1UVw>? M4XPSWlvcGmkaYTpc44hd2ZidIXieYxqdiCyb3z5cYVzcXqjdHnvci=> M1LjeFg6QDh4MES=
C6 NGjUd2dEgXSxdH;4bYMhSXO|YYm= MmTFNk42KG2pL33M M2rxXFUhcA>? NX3sW29CTE2VTx?= NIm1UY1EgXSxdH;4bYNqfHliYYPz[ZN{\WRiYYOgZ4VtdCC{ZXzlZZNm NXnRR2hwQDl6OE[wOC=>
SKVLB M3L6ZmN6fG:2b4jpZ{BCe3OjeR?= M17sTFczKGh? MV7JR|UxRTZwNUSg{txO NVLINJREQTByM{WyNC=>
MCF7/VP16 NVjuUZNsS3m2b4TvfIlkKEG|c3H5 M3HDSVUxKM7:Zz;tUC=> MYW3NkBp MoPuTWM2OD1zND6yJO69VQ>? NHvNZ446ODJ{N{my
CA755 M4DqWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlnzNVAh|ryP NVTGWppHPiCm M37uXWlEPTB;MD6wNVQh|ryP NV7hUZlyQTV{NkW3NC=>
CHO MmDVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVexNEDPxE1? NHzpUZc3KGR? MWLJR|UxRTBwME[g{txO MWO5OVI3PTdy
Panc02 NUXOcItTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYGxNEDPxE1? M4PoPFYh\A>? NXjlRVVZUUN3ME2wMlA3PSEQvF2= MmL5PVUzPjV5MB?=
PC14 M1P4eGN6fG:2b4jpZ{BCe3OjeR?= M1ziOlQh\A>? NHToWYxFVVOR MVHJR|UxRTBwMkmg{txO MWS5PFIzPTR{
HOP62 NUC5eGpyS3m2b4TvfIlkKEG|c3H5 NUjW[JJ[PzJiaB?= NHOySHRKSzVyPUCuNFA1KM7:TR?= MlX5PVg4OzZ4MR?=
SF-295 NXu4TIE1S3m2b4TvfIlkKEG|c3H5 NWnBVZJkPzJiaB?= MkT5TWM2OD1yLkCzOUDPxE1? MXe5PFc{PjZz
MDA-MB-361 MoXrR5l1d3SxeHnjJGF{e2G7 MmHJNUBp MXjEUXNQ MojiR5l1d3SxeHnjbZR6KGGpYXnud5QhVUSDLV3CMVM3OSCneIDy[ZN{cW6pIFzhZ3ohf2m2aDDJR|UxKG:oIECuNFEzKM7:TR?= NXr1dpptOTB|OUW0PVA>
MDA-MB-361 NWGzdVE5S3m2b4TvfIlkKEG|c3H5 NHvEcnEyKGh? NHjUOm1FVVOR M1PUbmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KE2GQTDNRkA{PjFiZYjwdoV{e2mwZzDjZZJjd3i7cHXweIll[XOnIIP0R3BIOiC5aYToJGlEPTBib3[gNE4xOThizszN MmDkNVA{QTV2OUC=
CCRF-SB MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3POEBl MXHEUXNQ MnvWTWM2OD1yLkCxJO69VQ>? MnvjNVA1OTF2N{[=
CHO-K1 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1P5VlQh\A>? NVrP[FdFTE2VTx?= NX\VTVcxUUN3ME2wMlQh|ryP NHvlOowyODRzMUS3Oi=>
KB NIfieGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M13sT|Qh\A>? NEDIdZlFVVOR MmG3RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDkdpVoNXKnc3nzeIFvfCCNQkfEJJdqfGhiSVO1NEBw\iByLk[1JO69VQ>? Mn;iNVA1OTF2N{[=
KB NH;wTVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEHZZYE1KGR? NXXxeJJQTE2VTx?= NV\HVlJJSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBlenWpLYLld4l{fGGwdDDLRmNidXC5aYToJGlEPTBib3[gNE4xPiEQvF2= M2LJSlExPDFzNEe2
KB M2e5[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXq0JIQ> MULEUXNQ NWrUbWhrSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBlenWpLYLld4l{fGGwdDDLRm1FWiC5aYToJGlEPTBib3[gNE42KM7:TR?= MlexNVA1OTF2N{[=
KB MkDsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWrFSFY{PCCm NHHRPHFFVVOR MVrBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHTyeYcuemW|aYP0ZY51KEuEVkKwR{B4cXSqIFnDOVAhd2ZiMD60JO69VQ>? MkPkNVA1OTF2N{[=
HTB-54 NIizNFFEgXSxdH;4bYMhSXO|YYm= NF;wRVYyODBizszN MXTJR|UxRTFwMTFOwG0> MYixNFQ4Pjh4MR?=
MEL-AC MlfkR5l1d3SxeHnjJGF{e2G7 MUmxNFAh|ryP MVHJR|UxRTFwMjFOwG0> MmXuNVA1PzZ6NkG=
DU145 MlrMR5l1d3SxeHnjJGF{e2G7 NFrSS404OiCq MXjJR|UxRTBwMEWyPEDPxE1? NUO3V|RsOTB2N{myPFI>
K562R Mn;JR5l1d3SxeHnjJGF{e2G7 M2jqSlczKGh? NH\RZWVKSzVyPUCuNFE2PiEQvF2= NIX1cpYyODR5OUK4Ni=>
PACA-2 MlTTR5l1d3SxeHnjJGF{e2G7 M{HZblYh\A>? NXH1fIxRTUR3ME2wMlAxPjNizszN M{XOZlExPDl6MkG0
3Y1 MVTDfZRwfG:6aXOgRZN{[Xl? M2PmO|czKGh? M2nDbWdKPTB;MD6wNFM5KM7:TR?= MlXiNVA3QTF5MUC=
P388 M3HLcWN6fG:2b4jpZ{BCe3OjeR?= NXntS3ZsPzJiaB?= NHjRclFIUTVyPUCuNFEzKM7:TR?= MlG2NVA3QTF5MUC=
HMV-1 M{n6UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlfDTWM2OD1yLkK4JO69VQ>? NH[3XJIyODZ7OESzOi=>
MKN-1 MmDoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWn2bYpEUUN3ME2wMlY1KM7:TR?= NU\tUWM2OTB4OUi0N|Y>
PC14 NFHySmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoXsTWM2OD1zLkmg{txO M160SlExPjl6NEO2
T24 NGnWOmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zBdmlEPTB;MD62OEDPxE1? NXzEVI92OTB4OUi0N|Y>
U937 MmrWSpVv[3Srb36gRZN{[Xl? MlnWNlQhcA>? M1fWOWROW09? MWDJcohq[mm2czDpcoNwenCxcnH0bY9vKG:oIGuzTH11cHmvaXTpcoUhf2m2aDDJR|UxKG:oIECuNUDPxE1? NWW4fYRrOTB5OEC5NVE>
H460pv8/eto MXzDfZRwfG:6aXOgRZN{[Xl? NUTVWm0{OTByIN88US=> MmjtOFghcA>? MWPTZYxqdmV? MUHJR|UxRTBwMEKg{txO MmfQNVA4QDB7MUO=
H460pv8 NFfEbWZEgXSxdH;4bYMhSXO|YYm= MXixNFAh|ryP M3XNVFQ5KGh? MVXTZYxqdmV? MYjJR|UxRTBwMEC0JO69VQ>? MYSxNFc5ODlzMx?=
MDA-231 NF;sZZlEgXSxdH;4bYMhSXO|YYm= MUWxNFAh|ryP M33yVlQ5KGh? MVXTZYxqdmV? MYrDfZRwfG:6aXPpeJkh[WejaX7zeEBOTEFvMkOxJINmdGxiKFXSMUxGT0[UKzzteZRidnRicEWzLUB4cXSqIFnDOVAhd2ZiMD6wNFYh|ryP MX2xNFc5ODlzMx?=
MDA-468 Mn;DR5l1d3SxeHnjJGF{e2G7 NH\NflcyODBizszN MmPUOFghcA>? MUfTZYxqdmV? M3q2S2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KE2GQT20Olgh[2WubDCoSXIuNCCjbYDsbYZq\WRiRVfGVkwhdXW2YX70JJA2Oylid3n0bEBKSzVyIH;mJFAvODB3IN88US=> M1rqR|ExPzhyOUGz
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HepG2 MV3DfZRwfG:6aXOgRZN{[Xl? NV;Ud5p6OTByIN88US=> NX;WSIhTPzJiaB?= MmPDTWM2OD1yLkC3JO69VQ>? Ml3LNVgyQDF3N{W=
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OVCAR-8 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHXDT|NKSzVyPU[xMlkzKG6P NHfyUW9USU6JRWK=
HL-60 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4HqRmlEPTB;NkKuOVYhdk1? MmjhV2FPT0WU
8305C M{npO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3zEdWlEPTB;NkOuNVIhdk1? Ml7TV2FPT0WU
IA-LM MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3sTWM2OD14Mz61OEBvVQ>? MUXTRW5ITVJ?
HCC2157 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1rRXmlEPTB;NkOuPVUhdk1? NGW2SWFUSU6JRWK=
CTB-1 MmfWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2fZeGlEPTB;NkSwNVkhdk1? MUXTRW5ITVJ?
NCI-H1437 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIDPNIFKSzVyPU[0MlY1KG6P MWfTRW5ITVJ?
U251 Ml3GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTZ2Lki5JI5O M3fYeXNCVkeHUh?=
ALL-PO NEfPOmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkHGTWM2OD14NT6wN{BvVQ>? M{fIfnNCVkeHUh?=
NCI-SNU-1 M4\pZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\kTWM2OD14NT64OkBvVQ>? Mkj6V2FPT0WU
RPMI-6666 M37XcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlvCTWM2OD14NT65PUBvVQ>? MY\TRW5ITVJ?
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GT3TKB MlrGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI\hWHhKSzVyPU[3MlE6KG6P NGO4SnNUSU6JRWK=
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CAL-33 NX7i[lF2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWTJR|UxRTZ5Lki3JI5O NGPSR3dUSU6JRWK=
MC-IXC Mn3oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTZ5Lkmgcm0> MWfTRW5ITVJ?
CPC-N NH;3VnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWPhR2JDUUN3ME22PE41KG6P NInEUYlUSU6JRWK=
A2780 NXvZSGJxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2HhdWlEPTB;NkiuO|khdk1? MoDPV2FPT0WU
Daudi MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTZ6Lkm2JI5O MnrBV2FPT0WU
GI-1 MlW1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1ricWlEPTB;NkmuOlUhdk1? NHT1[FNUSU6JRWK=
SW962 M{XkeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\WPGxTUUN3ME22PU46PSCwTR?= MkLPV2FPT0WU
MFE-296 M1TlRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTdyLkS5JI5O MnHYV2FPT0WU
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HCC1599 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVK4SYIxUUN3ME23Nk42PCCwTR?= MnL4V2FPT0WU
HuCCT1 M3zvb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFfqXnZKSzVyPUeyMlk{KG6P M1\uXXNCVkeHUh?=
Calu-1 M2fhcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoHyTWM2OD15Mz62JI5O NWjkXIxCW0GQR1XS
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IST-SL2 Mk\4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHvMd4JKSzVyPUezMlgyKG6P MVHTRW5ITVJ?
HSC-3 NILLZZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWLKcpg1UUN3ME23OE42OyCwTR?= NYfHeWNXW0GQR1XS
HCC1806 NVPKUmhmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUO3b4pxUUN3ME23OE46PiCwTR?= M4qyXnNCVkeHUh?=
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HSC-4 MojPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4S2WWlEPTB;N{WuO|Yhdk1? MUDTRW5ITVJ?
NH-12 MmO5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYr3RoFPUUN3ME23OkBvVQ>? NYjING5RW0GQR1XS
MDA-MB-468 MkflS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGKxSnBKSzVyPUe2MlE5KG6P NH\YR|dUSU6JRWK=
TUR NWP1UW9ST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFGy[45KSzVyPUe2MlMzKG6P MXzTRW5ITVJ?
TE-1 NXfyZlR1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3nrXmlEPTB;N{[uN|Uhdk1? NGm5XVlUSU6JRWK=
CMK M1\mRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmjwTWM2OD15Nz60NkBvVQ>? MV\TRW5ITVJ?
LB996-RCC NHP4WoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTd6LkS1JI5O NF7jVWNUSU6JRWK=
NCI-H1650 NVfaN3dbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUH4S4xSUUN3ME23PE43OiCwTR?= NV7tRYNzW0GQR1XS
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NOS-1 NX7KV41sT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXfrcHBXUUN3ME23PU4yPCCwTR?= MX3TRW5ITVJ?
NB69 MmDPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vsdmlEPTB;N{muNkBvVQ>? NYewe5liW0GQR1XS
SUP-T1 M3vxZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3iwdGlEPTB;N{muO|Ihdk1? MVvTRW5ITVJ?
A172 NFe0VZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlXSTWM2OD16MD61OUBvVQ>? MkK3V2FPT0WU
TE-12 NXHH[JcxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXLJR|UxRThzLkC2JI5O M4XsR3NCVkeHUh?=
MKN45 NEHoUGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvrblJKSzVyPUixMlUyKG6P NGXSWXJUSU6JRWK=
LoVo M3ewemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{fkTWlEPTB;OEGuPFIhdk1? NFjHRmtUSU6JRWK=
SW1573 MoXyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDXTWM2OD16Mj64NUBvVQ>? MkHuV2FPT0WU
ETK-1 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVPWbJduUUN3ME24N{4xOSCwTR?= MV\TRW5ITVJ?
ABC-1 NVfxcmtbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmrlTWM2OD16Mz60OUBvVQ>? MVzTRW5ITVJ?
COLO-668 M{fvUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHOyVGlKSzVyPUi0MlQ4KG6P NVLjdpBMW0GQR1XS
UM-UC-3 M3HET2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRTh4LkCyJI5O NFHxZnJUSU6JRWK=
BC-1 NHzPO|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\DTm5kUUN3ME24Ok44PiCwTR?= MnzwV2FPT0WU
PANC-10-05 NHG5ZZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTh6LkS1JI5O NEKyfHVUSU6JRWK=
ES3 M17XTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4WxeGlEPTB;OEmuOFghdk1? MmexV2FPT0WU
TE-441-T M2C0Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYnscVRFUUN3ME24PU45OiCwTR?= NHnSWoRUSU6JRWK=
KM-H2 MnnWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYDjUotnUUN3ME25NE43QCCwTR?= MVLTRW5ITVJ?
SH-4 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHvtTFRKSzVyPUmyMlEyKG6P MnjnV2FPT0WU
SF268 MnjwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV;3[3VjUUN3ME25Nk41OiCwTR?= MlzrV2FPT0WU
VMRC-RCZ M4rCVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\YfpplUUN3ME25N{4zPiCwTR?= M2q2dnNCVkeHUh?=
GI-ME-N M4K5Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1fLOmlEPTB;OUOuN|Mhdk1? MX\TRW5ITVJ?
JEG-3 M13lZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\qTWM2OD17NT6xNkBvVQ>? M{f0ZnNCVkeHUh?=
J-RT3-T3-5 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIjwN5BKSzVyPUm2MlMyKG6P NY\3Onh7W0GQR1XS
K5 M17jfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFTnU3JKSzVyPUm2Mlkhdk1? M3HsVnNCVkeHUh?=
EFO-27 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYLRc3M5UUN3ME25O{41PCCwTR?= MXzTRW5ITVJ?
SW1783 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1y4WWlEPTB;OUeuPVkhdk1? MXHTRW5ITVJ?
CAL-39 MmnGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnG4TWM2OD17OD6yOEBvVQ>? NV;afmFbW0GQR1XS
LS-441N M3LkUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1vEb2lEPTB;OUmuNFYhdk1? MV;TRW5ITVJ?
G-402 NUPJTYttT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4XWcmlEPTB;OUmuNFkhdk1? M1;FU3NCVkeHUh?=
MES-SA MmPwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2\BWGlEPTB;OUmuOVMhdk1? NX7qZWJ[W0GQR1XS
FADU NEXyRXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoLiTWM2OD1zMEKuNVghdk1? Mn7iV2FPT0WU
DJM-1 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\JR|UxRTFyMj6yOUBvVQ>? MWXTRW5ITVJ?
SU-DHL-1 NI\T[pJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWLQRpFUUUN3ME2xNFIvPSCwTR?= NFn3VZpUSU6JRWK=
KYSE-410 M3zCWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MULJR|UxRTFyMz60OkBvVQ>? NFTh[|hUSU6JRWK=
NCI-H1618 MlHsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2j3b2lEPTB;MUC0MlM2KG6P NX3JW5Q3W0GQR1XS
AU565 Mmi3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NG\LWWpKSzVyPUGwOE42OSCwTR?= NFqwcoVUSU6JRWK=
SF126 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTFyND61PEBvVQ>? NEfsclZUSU6JRWK=
MMAC-SF M4rXW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{[yW2lEPTB;MUC2MlQ5KG6P NFLIRW5USU6JRWK=
ChaGo-K-1 NWPQOnlkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnnuTWM2OD1zMEeuPVUhdk1? MUXTRW5ITVJ?
NCI-H596 MmO5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGHrZ4dKSzVyPUGwPE4xOSCwTR?= Mo\PV2FPT0WU
LXF-289 NIPISmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYXqVVM4UUN3ME2xNFkvOjRibl2= NILSOG5USU6JRWK=
HCC1569 M1;RcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYnQU4g1UUN3ME2xNFkvOzRibl2= NVr0fG5IW0GQR1XS
NCI-H2170 MkLUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmjzTWM2OD1zMEmuPVIhdk1? M2LsN3NCVkeHUh?=
ARH-77 NYDYRmVRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWPxZVRLUUN3ME2xNFkvQTlibl2= NIjtXHFUSU6JRWK=
BOKU MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{HxXWlEPTB;MUGwMlg4KG6P MXPTRW5ITVJ?
SJSA-1 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTFzMT6wOUBvVQ>? NHXnepBUSU6JRWK=
SW626 Ml36S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUPKdHVxUUN3ME2xNVEvPzFibl2= M4rIZ3NCVkeHUh?=
EHEB MlvaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnvVTWM2OD1zMUKuOVkhdk1? M4eyXnNCVkeHUh?=
TE-10 Mke5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUDnfJhJUUN3ME2xNVIvPjhibl2= MUTTRW5ITVJ?
MZ7-mel MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTFzMj64OEBvVQ>? M4nOZ3NCVkeHUh?=
SAS MnHDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7lXY5ZUUN3ME2xNVQvPDVibl2= MoXtV2FPT0WU
TK10 NFq5TnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmfOTWM2OD1zMUSuOkBvVQ>? NIjvSndUSU6JRWK=
SW13 M{eySmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnOyTWM2OD1zMUWuNlYhdk1? NV\Ee3FiW0GQR1XS
HCC1937 NH7GN2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWn2fIxoUUN3ME2xNVUvQDRibl2= MX\TRW5ITVJ?
SK-NEP-1 M3P5Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3n3O2lEPTB;MUG2MlI3KG6P MXrTRW5ITVJ?
OVCAR-5 MnnFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVnoRW8{UUN3ME2xNVYvQDFibl2= NGTTUI9USU6JRWK=
SW837 M1;kcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTtTWM2OD1zMUeuPVUhdk1? NUTvWFJMW0GQR1XS
BFTC-909 Ml7pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkGzTWM2OD1zMUiuOFghdk1? MUfTRW5ITVJ?
SW872 NIrWcWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTF{MD64NUBvVQ>? NFjpVYVUSU6JRWK=
SF539 Ml3XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHXTWM2OD1zMkGuO|Ihdk1? M1XWXHNCVkeHUh?=
MLMA NWPwO|ZKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRTF{Mj6wPEBvVQ>? MojrV2FPT0WU
BL-41 NF;Nb3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{jzc2lEPTB;MUKyMlIzKG6P MkTnV2FPT0WU
LB647-SCLC NHnsSW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTF{Mz6zOUBvVQ>? NWnPOXJwW0GQR1XS
NCI-H1703 M4HOT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUKzXldtUUN3ME2xNlYvPDJibl2= NXHLOFM1W0GQR1XS
KURAMOCHI MkT1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHG4[HFKSzVyPUGyOk44PiCwTR?= M2nk[HNCVkeHUh?=
ATN-1 NHrIZmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGW5ZmZKSzVyPUGyO{44KG6P Ml7VV2FPT0WU
SK-CO-1 NHTUboZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1rUN2lEPTB;MUK5MlIyKG6P MoXRV2FPT0WU
RPMI-7951 NFXHU|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHeyTldKSzVyPUGzNE4yPCCwTR?= NULo[YRGW0GQR1XS
NCI-H1648 M4XhTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH;0WYRKSzVyPUGzNU46PCCwTR?= NFLPS2tUSU6JRWK=
NCI-H64 NG\rco1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVjPOox[UUN3ME2xN|IvPjVibl2= M1fDUXNCVkeHUh?=
HT-3 M1fZWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIOyRmJKSzVyPUGzN{4xPCCwTR?= NGTyUVVUSU6JRWK=
NCI-H1770 MkntS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnOPVQzUUN3ME2xN|MvOjFibl2= MmTFV2FPT0WU
NB13 NVSyVIxbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2H6bWlEPTB;MUO0MlU2KG6P Moj3V2FPT0WU
NCI-H747 NGPuWHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3fTVmlEPTB;MUO1MlAzKG6P MWXTRW5ITVJ?
ML-2 NFjuXpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3juUmlEPTB;MUO1MlE3KG6P MkjpV2FPT0WU
CA46 Moj1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTF|Nj64PEBvVQ>? MXnTRW5ITVJ?
ES6 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1LWb2lEPTB;MUO3MlEzKG6P NW\rWld1W0GQR1XS
JiyoyeP-2003 M3\N[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4rwXWlEPTB;MUO3Mlghdk1? NGjzZlNUSU6JRWK=
NMC-G1 NYj2TnN1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTF|OT6xN{BvVQ>? NE\tU4lUSU6JRWK=
U-698-M MnPsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkfXTWM2OD1zM{muOUBvVQ>? MlTyV2FPT0WU
LU-99A MoDvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTF2Nj61OUBvVQ>? NF3MepNUSU6JRWK=
NCI-H748 NYCxVnFKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml3RTWM2OD1zNEeuN|Ehdk1? NXPQOGM6W0GQR1XS
SK-MEL-3 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4rtVmlEPTB;MUS3MlYyKG6P MXfTRW5ITVJ?
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BB65-RCC M2jXcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEfEN5FKSzVyPUG0PU4{OSCwTR?= M2CxbHNCVkeHUh?=
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LC-1F NF3ZOIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTFwNk[yNFMh|ryP MoO0V2FPT0WU
KP-N-YN NGfsPWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M13MOGlEPTB;MT62OlM1OyEQvF2= NXfDNHduW0GQR1XS
MFE-280 M3roXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{f0ZmlEPTB;MT62OlgyOiEQvF2= M2jZe3NCVkeHUh?=
S-117 M1S2e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1zm[GlEPTB;MT63NFUxPCEQvF2= Ml7GV2FPT0WU
NCI-H1573 NUK5dWN[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{TENWlEPTB;MT63NVc{OyEQvF2= MX;TRW5ITVJ?
BT-20 M1nHdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoTWTWM2OD1zLke0NFY5KM7:TR?= MYDTRW5ITVJ?
NCI-H28 Mm[2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTFwN{SwO|gh|ryP MljDV2FPT0WU
CaR-1 MlTlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NG\iW2hKSzVyPUGuO|g{OjRizszN MWDTRW5ITVJ?
LN-405 MkfJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTFwOECxOFMh|ryP NUK5WJV{W0GQR1XS
RT4 M{iwUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUO4PFd4UUN3ME2xMlg1PDF5IN88US=> MWPTRW5ITVJ?
NCI-H889 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml25TWM2OD1zLkmzPFg3KM7:TR?= NV;tOpBYW0GQR1XS
SW1463 NGjIZ3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEe5dJpKSzVyPUGuPVU4ODFizszN MUjTRW5ITVJ?
SCLC-21H MnG4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVjPdGhEUUN3ME2yMlAxPjJ2IN88US=> NV\aUmZxW0GQR1XS
CP66-MEL NUDnO2RFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2S3WmlEPTB;Mj6wNVc3PyEQvF2= NW\WVJBZW0GQR1XS
Hs-578-T M3TzVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4T4ZmlEPTB;Mj6wNVc5OiEQvF2= M2DRdHNCVkeHUh?=
HCC70 NEPNZWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGqzcXRKSzVyPUKuNFU1PjNizszN NGfTPVRUSU6JRWK=
SW1088 NVLWOZc2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jxV2lEPTB;Mj6wOlk{OSEQvF2= M4K4c3NCVkeHUh?=
NB6 M2roT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTJwMUi1JO69VQ>? NIH2OVRUSU6JRWK=
KU-19-19 M1nldWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWroSnVXUUN3ME2yMlI3QTF5IN88US=> MkKyV2FPT0WU
A704 M{Dne2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWTMZ3ZpUUN3ME2yMlI6OTN3IN88US=> M33Tc3NCVkeHUh?=
EVSA-T M3PudGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4DXcmlEPTB;Mj6zNFA5QSEQvF2= MmPhV2FPT0WU
HCT-15 NFXa[5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mme1TWM2OD1{LkO1OFY3KM7:TR?= M1X0SnNCVkeHUh?=
HuO-3N1 NXjEfWpiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTJwM{[1PFMh|ryP NEXp[2ZUSU6JRWK=
GMS-10 NHzDUnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3:4fmlEPTB;Mj6zPVc{QCEQvF2= NX30dnFYW0GQR1XS
TGBC24TKB M2HK[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2i1b2lEPTB;Mj60NVQzQSEQvF2= M2ToZnNCVkeHUh?=
C2BBe1 M4XvbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3vtbWlEPTB;Mj61NVMzQCEQvF2= NGjNXG1USU6JRWK=
SK-N-DZ NFPHUmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkOwTWM2OD1{LkW2OVkzKM7:TR?= M3K4PXNCVkeHUh?=
SK-N-AS M2q1XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnXkTWM2OD1{LkezNFE2KM7:TR?= NIjG[GxUSU6JRWK=
T98G M1vVU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmTXTWM2OD1{LkiwOFAyKM7:TR?= NUXZfXlPW0GQR1XS
DMS-79 NWPjRoNST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlfYTWM2OD1{LkmwPVg5KM7:TR?= M1nEOnNCVkeHUh?=
SNU-475 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTJwOUK1O|Ih|ryP NUPOSlVNW0GQR1XS
COLO-792 NFGxfodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4WxSGlEPTB;Mz6wNlg4KM7:TR?= MYHTRW5ITVJ?
YAPC MknjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1:5[WlEPTB;Mz6zNlg{OiEQvF2= Ml7IV2FPT0WU
UACC-812 MnXHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLTTWM2OD1|LkOzO|M5KM7:TR?= MYTTRW5ITVJ?
Mewo NVfwUpIzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml74TWM2OD1|LkS2NFg3KM7:TR?= M2\TSHNCVkeHUh?=
COLO-824 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mm\0TWM2OD1|LkW3N|c5KM7:TR?= NH\k[HVUSU6JRWK=
SCC-9 Ml7jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVPWb2tUUUN3ME2zMlkyOzB7IN88US=> MkXMV2FPT0WU
CP50-MEL-B MonGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHJR|UxRTNwOUi3NFMh|ryP MV\TRW5ITVJ?
NCI-H345 NFmze3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkDWTWM2OD12LkCxNVc1KM7:TR?= NEnRUGNUSU6JRWK=
COR-L88 NVjR[HF6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1fnWmlEPTB;ND6zPVU5KM7:TR?= NEDmdJRUSU6JRWK=
RCM-1 NWHNN4VWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEO0fZBKSzVyPUSuOFkzPzJizszN M{L3RnNCVkeHUh?=
JVM-3 NFTWT|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWLGUZZqUUN3ME20MlYxPjF6IN88US=> NXTFXW5RW0GQR1XS
ECC4 NUPj[Y1NT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2LlSGlEPTB;ND63OlU1OSEQvF2= M3jObHNCVkeHUh?=
MDA-MB-453 M3HY[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFvTOVZKSzVyPUSuPFUyOzRizszN NH;wS4xUSU6JRWK=
SK-N-FI M4XxcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUfjZ4NsUUN3ME21MlIzQDd5IN88US=> MlXCV2FPT0WU
D-502MG NV\JSJFCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmHiTWM2OD13LkK0NlYzKM7:TR?= NGL4T3ZUSU6JRWK=
NCI-H2227 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWDaXlc4UUN3ME21MlM3OjNzIN88US=> MXXTRW5ITVJ?
DMS-53 M1H5Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmHVTWM2OD14LkG3NVA3KM7:TR?= M4jwOHNCVkeHUh?=
LB771-HNC NYTnPVg{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHrOOJdKSzVyPU[uOFY5ODZizszN MorsV2FPT0WU
BB49-HNC NFHWV3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnnrTWM2OD15LkSxO|kyKM7:TR?= NHfmNVFUSU6JRWK=
MDA-MB-415 M4j4NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3uydmlEPTB;Nz61O|MxOyEQvF2= NH7OdlNUSU6JRWK=
TALL-1 NWK2WXo1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIexephKSzVyPUeuPVY5QCEQvF2= NIHYSGlUSU6JRWK=
HCC1395 NVS1bHJ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnHZTWM2OD16LkG1NVIzKM7:TR?= NHfN[FVUSU6JRWK=
EFE-184 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmfkTWM2OD16LkO3NlE3KM7:TR?= NELidmpUSU6JRWK=
EC-GI-10 NEDTcGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWLweohMUUN3ME24MlY5Pjh4IN88US=> MYDTRW5ITVJ?
TT NUnBe5VXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mof6TWM2OD17LkC2PVY3KM7:TR?= NHLPfYtUSU6JRWK=
U-2-OS MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVvxR3dDUUN3ME25MlgyOzl|IN88US=> NWjabnhlW0GQR1XS
SHP-77 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTlwOUCyPUDPxE1? MnK2V2FPT0WU
HCC1143 NUjx[|Y3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NETt[lVKSzVyPUGwMlQ4QTdizszN M13aPHNCVkeHUh?=
A498 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIG5TIVKSzVyPUG4MlI6PzZizszN NH\qd2hUSU6JRWK=
LS-513 MmXDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTF6Lk[wPVMh|ryP MWnTRW5ITVJ?
K052 M4nxVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVPJR|UxRTJzLkS0NVgh|ryP NUjZUXA2W0GQR1XS
SiHa MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEjiVHRKSzVyPUKzMlM{PzFizszN NIjhOolUSU6JRWK=
RCC10RGB NXfpfFZzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\uSHJRUUN3ME2zNE4xPjFzIN88US=> MVPTRW5ITVJ?
NCI-SNU-16 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mlz1TWM2OD1|MT6xPFM3KM7:TR?= M3;EVXNCVkeHUh?=
SNU-C1 Mn7CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTN{LkSxO|Uh|ryP NUize2VrW0GQR1XS
C32 NWiwZXhPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\2cVRiUUN3ME2zNk45PzJizszN M3;zR3NCVkeHUh?=
SW684 M3v6U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWHJR|UxRTN2LkG1OlEh|ryP M3r3N3NCVkeHUh?=
SK-MEL-28 M2jmOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV31S4V2UUN3ME2zOU42Ozd5IN88US=> M2Ha[3NCVkeHUh?=
SK-MEL-1 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTN4Lke1OFch|ryP NWr1eIM3W0GQR1XS
NCI-H720 M3O3RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVzpflZMUUN3ME20NU46PzJ4IN88US=> NVXHUVVXW0GQR1XS
P31-FUJ NVPwSnBET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYGyOVJFUUN3ME20OE4{Ojh2IN88US=> MYXTRW5ITVJ?
NCI-H524 M4fHSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUHJdIlKUUN3ME20PE45OjR6IN88US=> NH3QZolUSU6JRWK=

... Click to View More Cell Line Experimental Data

In vivo In vivo, Doxorubicin in combination with adenoviral MnSOD (AdMnSOD) plus 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) has the greatest effect in decreasing the volumes of MB231 tumors and prolonging survival of mice. [1] Although its use is limited by the chronic and acute toxic side effects it produces, Doxorubicin is essential in treating breast and oesophageal carcinomas, solid tumours in childhood, osteosarcomas, Kaposi's sarcoma, soft tissue sarcomas, and Hodgkin and non-Hodgkin lymphomas. [2]

Protocol

Animal Research:[1]
+ Expand
  • Animal Models: Female athymic nude mice injected s.c. with MB231 cells
  • Formulation: Dissolved in DMSO, and diluted in saline
  • Dosages: 3 mg/kg/day
  • Administration: Delivered intratumorly
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL warmed (172.41 mM)
Water 20 mg/mL (34.48 mM)
Ethanol <1 mg/mL
In vivo

* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 579.98
Formula

C27H29NO11.HCl

CAS No. 25316-40-9
Storage powder
in solvent
Synonyms NSC 123127

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03036904 Not yet recruiting Diffuse Large B-Cell Lymphoma|High Grade B-Cell Lymphoma Weill Medical College of Cornell University|Genentech, Inc.|Massachusetts General Hospital|M.D. Anderson Cancer Center February 6, 2017 Phase 1
NCT02659930 Recruiting Kaposi Sarcoma National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) January 4, 2016 Phase 1
NCT03042819 Not yet recruiting Soft Tissue Sarcoma University Health Network, Toronto|Karyopharm Therapeutics, Inc March 27, 2017 Phase 1
NCT03033914 Recruiting Hodgkin Lymphoma Memorial Sloan Kettering Cancer Center|Bristol-Myers Squibb|M.D. Anderson Cancer Center|City of Hope Medical Center January 25, 2017 Phase 1
NCT02957968 Recruiting Locally Advanced Breast Cancer|Invasive Adenocarcinoma of the Breast|Breast Cancer Stage II|Breast Cancer Stage III|Breast Cancer Stage IV Virginia Commonwealth University|Merck Sharp & Dohme Corp.|National Cancer Institute (NCI) January 24, 2017 Phase 2
NCT02377752 Active, not recruiting Neoplasm Eli Lilly and Company March 23, 2015 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Topoisomerase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID