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S1208

Adriamycin (Doxorubicin)

 (Synonyms

Rubex

)
Technical Data:
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Adriamycin (Doxorubicin)
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M.Wt: 579.98
Formula: C27H29NO11.HCl
Solubility: DMSO
Purity: >99%
Storage: at -20℃ 2 years
CAS No.: 25316-40-9
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Price and Availability of Adriamycin (Doxorubicin):

  USD Qty  
25mg / $210In Stock
100mg / $670In Stock
10mg / $90In Stock
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Applications & Customer's Feedback of Adriamycin (Doxorubicin):

  • Adriamycin was purchased from Selleck. Data from Mol Cancer Ther 2011 October; 10:1846-56.

    Tozasertib is more effective in comparison to- and shows synergistic potential with etoposide and doxorubicin. (A) Dose-response curves of tozasertib, doxorubicin and etoposide in SK-ES-1 and A673.

Biological Activity of Adriamycin (Doxorubicin):

Adriamycin (Doxorubicin) is a topoisomerase II inhibitor with IC50 of 1 and 2 μM for the inhibition of MCF-7 and MDA-MB231, respectively. Adriamycin (Doxorubicin) is an anthracycline antibiotic and is used in cancer chemotherapy. Adriamycin (Doxorubicin) inhibits the progression of the enzyme topoisomerase II, which relaxes supercoils in DNA for transcription. Doxorubicin stabilizes the topoisomerase II complex after it has broken the DNA chain for replication, preventing the DNA double helix from being resealed and thereby stopping the process of replication. [1][2][3]

Quality Control:

MSDS
Batch S120802: H-NMR  HPLC  COA
Batch S120803: H-NMR  HPLC  COA

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