Doxorubicin (Adriamycin) Licensed by Pfizer

Catalog No.S1208

Doxorubicin (Adriamycin) is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis in tumor cells.

Price Stock Quantity  
USD 117 In stock
USD 90 In stock
USD 210 In stock
USD 670 In stock
Bulk Inquiry

Massive Discount Available

Free Overnight Delivery on all orders over $ 500.

Doxorubicin (Adriamycin) Chemical Structure

Doxorubicin (Adriamycin) Chemical Structure
Molecular Weight: 579.98

Validation & Quality Control

6 customer reviews :

Quality Control & MSDS

Related Compound Libraries

Product Information

  • Compare Topoisomerase Inhibitors
    Compare Topoisomerase Products
  • Research Area
  • Combination Therapy
    Combination Therapy

Product Description

Biological Activity

Description Doxorubicin (Adriamycin) is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis in tumor cells.
Targets Topo II [1]
(Tumor cells)
In vitro Doxorubicin, an antibiotic anthracycline, is commonly considered to exert its anti-tumor activity at two fundamental levels, altering DNA and producing free radicals to trigger apoptosis of cancer cells through DNA damage. Doxorubicin can block the synthesis of DNA by intercalating into the DNA strand, and inhibits DNA topoisomerase II (TOP2). Doxorubicin is most effective when cells are rapidly proliferating and expressing high levels of TOP2. Additionally, Doxorubicin can trigger apoptosis by producing ceramide (which prompts apoptosis by activating p53 or other downstream pathways such as JNK), the degradation of Akt by serine threonine proteases, the mitochondrial release of cytochrome c, increased FasL (death receptor Fas/CD95 ligand) mRNA production, and a greater production of free radicals. [2] Pre-treatment with GSNO (nitrosoglutathione) suppresses the resistance in the doxorubicin-resistant breast cancer cell line MCF7/Dx, accompanied by enhanced protein glutathionylation and accumulation of doxorubicin in the nucleus. [3] Doxorubicin induced G2/M checkpoint arrest are attributed to elevated cyclin G2 (CycG2) expression and phospho-modification of proteins in the ataxia telangiectasia mutated (ATM) and ATM and Rad3-related (ATR) signaling pathways. [5] Doxorubicin inhibits AMP-activated protein kinase (AMPK), resulting in SIRT1 dysfunction, p53 accumulation, and increased cell death in mouse embryonic fibroblasts (MEFs) and cardiomyocytes, which can be further sensitized by pre-inhibition of AMPK. [6] Doxorubicin elicits a marked heat shock response, and that either inhibition or silencing of heat shock proteins enhance the Doxorubicin apoptotic effect in neuroblastoma cells. Nanomolar Doxorubicin treatment of neuroblastoma cells causes dose-dependent over-ubiquitination of a specific set of proteins in the absence of measurable inhibition of proteasome, and loss of activity of ubiquitinated enzymes such as lactate dehydrogenase and α-enolase, the protein ubiquination patterns of which is similar to those with proteasome inhibitor Bortezomib, indicating that Doxorubicin may also exert its effect by damaging proteins. [8]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
L1210NIT1Z4tHfW6ldHnvckBCe3OjeR?=MVnJcohq[mm2aX;uJI9nKFKQQTDzfY51cGW|aYOge4l1cCCHREWwJI9nKDBwNUig{txOMkj0OFkxPTN4
Yoshida sarcomaNIjIW4RHfW6ldHnvckBCe3OjeR?=M4XTZmlvcGmkaYTpc44hd2ZiW{PIYXRlWiCrbnPvdpBwemG2aX;uJJdqfGhiSVO1NEBw\iByLkCyJO69VQ>?NEWwN3MyOzJ{OUi2
CHOMoLWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M4f3OmlEPTB;MD6wOkDPxE1?NH\4eYYyOzV2N{Ww
8226M3\vZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MoTnTWM2OD1yLkCzN{DPxE1?NEDK[nUyPDR5N{Ow
8226/ADRMofiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MX7JR|UxRTBwNU[g{txONU[3OFZmOTR2N{ezNC=>
MCF7/ADRNWP3b|ZmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MXvJR|UxRTNwMTFOwG0>M2riNVE1PDd5M{C=
H69M3v0eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MmjoTWM2OD1yLki3JO69VQ>?NIf1ZmgyPDd7NUi1
N417M1y2PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MmnrTWM2OD1yLkKzJO69VQ>?M2npRlE1Pzl3OEW=
H9NV61UVhPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M1\CU2lvcGmkaYTpc44hd2ZiSEmgZ4VtdHNiY3jyc45q[2GubImgbY5n\WO2ZXSge4l1cCC2aHWgTGlXNTFiKFi5M2lKUUJrIIfpeIghUUR3MDDv[kAxNjBzIN88US=>NUSwenZ4OTV2OE[4NS=>
T-C8166NXrDSW13T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NUXUNlRJUUR3ME2wMlAyKM7:TR?=M4HmNlE2PDh4OEG=
T-H9NGfBWpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M1zPemlFPTB;MD6wNUDPxE1?NIntXIUyPTR6Nkix
T-MT4MlrwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NGO2RopKTDVyPUCuNFEh|ryPM3zTPVE2PDh4OEG=
SKMEL-5M{ezO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NVnrd2YyTUR3ME2zMlIh|ryPM2\BUFE3OTN5NUO=
MLMM2LCfWN6fG:2b4jpZ{BCe3OjeR?=MUXFSFUxRTBwMUOg{txOM{LmbVE5PzV|NUC=
KBM-3MnW4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M4nDW2lEPTB;MD6wNlYh|ryPNWK0Vm1lOTl7NUi3Oy=>
HT-29NXj5cmp7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NWHtRppTOC5yMTFOwIc>NGToWGE1QCCqM13OZWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5MlTSNlc4QDR2OR?=
EMT6NIXJSHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NVPzOVlSOC53IN88US=>NFH0dVMyKGh?M1zrOGlvcGmkaYTpc44hd2ZicILvcIln\XKjdHnvckBjgSCvZXHzeZJqdmdiZn;yJJN2en[rdnnu[{BnemGldHnvcpMhf2m2aDDFSFUxKG:oIECuNFAxOSEQvF2=MWS3OFUzPjd2
H2981NX\5PVJZS3m2b4TvfIlkKEG|c3H5NV3DUWFKUUN3ME2wMlUh|ryPNUPTe4JjPzd|MUCyNy=>
LOXNU\qXVg3S3m2b4TvfIlkKEG|c3H5MVPJR|UxRTBwMESyJO69VQ>?M1S2eFc5PTN|M{G=
C38MoTDR5l1d3SxeHnjJGF{e2G7Ml3STWM2OD1yLkCxJO69VQ>?NXfsVYp2QDB3N{K5NS=>
EACMWDDfZRwfG:6aXOgRZN{[Xl?MVy3NkBpMlnYTWM2OD1yLkO1JO69VQ>?NFXxZpE5OzVyMEi3
SKVLBMlnBR5l1d3SxeHnjJGF{e2G7MnTFTWM2OD13Lk[g{txOMmLjPFU4PjlzNB?=
AUC375MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MkPzTWM2OD1yLkGxNkDPxE1?M1LXblg3PDh4MEC=
A2780-C25Mo\hR5l1d3SxeHnjJGF{e2G7M3LxWWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KG:6YXzpdIxifGmwLYLld4l{fGGwdDDBNlc5OC2FMkWge4l1cCCLQ{WwJI9nKDBwME[zJO69VQ>?NXT5W5A2QDh|MUe1OS=>
A2780-CP3M1WzXGN6fG:2b4jpZ{BCe3OjeR?=M4r5T2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGOrc4DsZZRqdi2{ZYPpd5RidnRiQUK3PFAuS1B|IIfpeIghUUN3MDDv[kAxNjB3NjFOwG0>NXzwc41DQDh|MUe1OS=>
A2780-DX5MULDfZRwfG:6aXOgRZN{[Xl?MXzDfZRwfG:6aXPpeJkh[WejaX7zeEBld3ixcoXibYNqdi2{ZYPpd5RidnRiQUK3PFAuTFh3IIfpeIghUUN3MDDv[kAxNjN3NzFOwG0>M3HTWFg5OzF5NUW=
MXF7M2LwV2N6fG:2b4jpZ{BCe3OjeR?=NI[0RmFCdnSrdIXtc5Ih[WO2aY\peJkh[WejaX7zeEB{\W6|aYTpeoUhVViINzD3bZRpKEmFNUCgc4YhOC5yMkig{txOMVy4PVYxPTV6
MXF7NI\BbGREgXSxdH;4bYMhSXO|YYm=NX:ydJNiSW62aYT1cY9zKGGldHn2bZR6KGGpYXnud5QhdWm2b4jhcpRzd26nLYLld4l{fGGwdDDNXGY4KHerdHigTWM2OCCxZjCwMlAzQCEQvF2=NIfCe4o5QTZyNUW4
MXF7NEX6bZNEgXSxdH;4bYMhSXO|YYm=MkfpRY51cXS3bX;yJIFkfGm4aYT5JIFo[Wmwc4Sg[I95d3K3YnnjbY4uemW|aYP0ZY51KE2[Rkege4l1cCCLQ{WwJI9nKDFwMUeyJO69VQ>?MU[4PVYxPTV6
WiDrNWrwZ3VTS3m2b4TvfIlkKEG|c3H5NGmyc2hC[3Srdnn0fUBi\2GrboP0JJNmdnOrdHn2[UBYcUS{IHPlcIwhf2m2aDDJR|UxKG:oIECuNFU{KM7:TR?=Ml70PFk3ODV3OB?=
MCFMVjGeY5kfGmxbjDBd5NigQ>?NUL6b4NKWmW4ZYLzZYwhd2ZiUD3ndE1u\WSrYYTl[EBufWy2aXTyeYchemW|aYP0ZY5k\SCjc4Pld5Nm\CCjczDlcohidmOnbXXueEBqdiCleYTveI95cWOrdImgc4Yh[WS{aXHtfYNqdg>?M1:wbFg6QDRzNUG=
C6NE\FU5FEgXSxdH;4bYMhSXO|YYm=MWeyMlUhdWdxbVy=NEf3cXM4OiCqMmezSG1UVw>?M2Psb2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KHKjdDDDOkBk\WyuczDheEA2OCC3Zz;tUEB1dyB{LkWgcYcwdUx?MoDUPFk5QDZyNB?=
C6M4ixWmZ2dmO2aX;uJGF{e2G7NETKbWozNjVibXevcWw>MXm0JIg>M2Hle2ROW09?NEnTb5BKdmirYnn0bY9vKG:oIIT1ZpVtcW5icH;sfY1memm8YYTpc44>NHTLcYE5QTh6NkC0
C6NX\0c|RRS3m2b4TvfIlkKEG|c3H5NXH0Tnh7Oi53IH3nM41NNV\mVY4zPSCqM1GzO2ROW09?MX;DfZRwfG:6aXPpeJkh[XO|ZYPz[YQh[XNiY3XscEBz\WynYYPlMVu4PVg5PjB2
SKVLBMnPOR5l1d3SxeHnjJGF{e2G7MUO3NkBpMVzJR|UxRTZwNUSg{txOMlzCPVAxOzV{MB?=
MCF7/VP16MoDkR5l1d3SxeHnjJGF{e2G7M2qyRlUxKM7:Zz;tUC=>NHHPeJk4OiCqMlL0TWM2OD1zND6yJO69VQ>?MkGzPVAzOjd7Mh?=
CA755NGniOo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M1z4fFExKM7:TR?=NXvMNG5NPiCmM1rCXGlEPTB;MD6wNVQh|ryPNWTsfXZXQTV{NkW3NC=>
CHOMnTuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?Mmi2NVAh|ryPMXu2JIQ>MXLJR|UxRTBwME[g{txOM{PDelk2OjZ3N{C=
Panc02NIHp[mxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M4X0dlExKM7:TR?=M1jtW|Yh\A>?MkjxTWM2OD1yLkC2OUDPxE1?NVHOTWdHQTV{NkW3NC=>
PC14MlrNR5l1d3SxeHnjJGF{e2G7MYe0JIQ>MW\EUXNQMWPJR|UxRTBwMkmg{txONVfMd5FoQTh{MkW0Ni=>
HOP62M{n2cmN6fG:2b4jpZ{BCe3OjeR?=MUG3NkBpM1XwRmlEPTB;MD6wNFQh|ryPMYK5PFc{PjZz
SF-295NGXNPZVEgXSxdH;4bYMhSXO|YYm=MlnqO|IhcA>?MVrJR|UxRTBwMEO1JO69VQ>?NUTTXphoQTh5M{[2NS=>
MDA-MB-361NIG5eFhEgXSxdH;4bYMhSXO|YYm=MnLZNUBpM4PCbGROW09?MYXDfZRwfG:6aXPpeJkh[WejaX7zeEBOTEFvTVKtN|YyKGW6cILld5NqdmdiTHHjXkB4cXSqIFnDOVAhd2ZiMD6wNVIh|ryPM1\WTVExOzl3NEmw
MDA-MB-361NUf5fFVLS3m2b4TvfIlkKEG|c3H5M2TueFEhcA>?MVjEUXNQNWfyfpRJS3m2b4TvfIlkcXS7IHHnZYlve3RiTVTBJG1DKDN4MTDlfJBz\XO|aX7nJINiemKxeInw[ZB1cWSjc3Wgd5REWEd{IIfpeIghUUN3MDDv[kAxNjBzODFOwG0>M2KzTlExOzl3NEmw
CCRF-SBNULtVWs{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M3u0U|Qh\A>?MYfEUXNQMWTJR|UxRTBwMEGg{txONWTXVnVbOTB2MUG0O|Y>
CHO-K1NHzqWGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MWe0JIQ>NXX0c4pITE2VTx?=NH6xWnRKSzVyPUCuOEDPxE1?M2LZe|ExPDFzNEe2
KBNELUeWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NWHGSJFyPCCmMWLEUXNQNFnKcpRCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIRzfWdvcnXzbZN1[W62IFvCO2Qhf2m2aDDJR|UxKG:oIECuOlUh|ryPMXKxNFQyOTR5Nh?=
KBNXXoXHVKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MoK0OEBlMojDSG1UVw>?MV3BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHTyeYcuemW|aYP0ZY51KEuEQ3HtdJdqfGhiSVO1NEBw\iByLkC2JO69VQ>?MlPBNVA1OTF2N{[=
KBMUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?Mn;XOEBlM2DuXWROW09?MV\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHTyeYcuemW|aYP0ZY51KEuETVTSJJdqfGhiSVO1NEBw\iByLkWg{txOMWCxNFQyOTR5Nh?=
KBNV\jfpBbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MlLsOEBlNGTHVWVFVVORNHfFUppCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIRzfWdvcnXzbZN1[W62IFvCWlIxSyC5aYToJGlEPTBib3[gNE41KM7:TR?=MUmxNFQyOTR5Nh?=
HTB-54MlXzR5l1d3SxeHnjJGF{e2G7MV2xNFAh|ryPNUPySmREUUN3ME2xMlEh|ryPMkKyNVA1PzZ6NkG=
MEL-ACM3[we2N6fG:2b4jpZ{BCe3OjeR?=M3zHPFExOCEQvF2=NGr4bY9KSzVyPUGuNkDPxE1?NYjhdVlUOTB2N{[4OlE>
DU145M{i0d2N6fG:2b4jpZ{BCe3OjeR?=M1;IPFczKGh?NUe1TYNRUUN3ME2wMlA2OjhizszNMWOxNFQ4QTJ6Mh?=
K562RNF3SdXpEgXSxdH;4bYMhSXO|YYm=M37BUFczKGh?NGPSZZBKSzVyPUCuNFE2PiEQvF2=NVe2VZhZOTB2N{myPFI>
PACA-2MY\DfZRwfG:6aXOgRZN{[Xl?Ml7hOkBlM1HYOWVFPTB;MD6wNFY{KM7:TR?=MkCwNVA1QTh{MUS=
3Y1NEPId49EgXSxdH;4bYMhSXO|YYm=M3HXelczKGh?Ml;1S2k2OD1yLkCwN|gh|ryPMXKxNFY6OTdzMB?=
P388MkHaR5l1d3SxeHnjJGF{e2G7MoLRO|IhcA>?MXPHTVUxRTBwMEGyJO69VQ>?M2TaXlExPjlzN{Gw
HMV-1NXu0N5BOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M{XvdmlEPTB;MD6yPEDPxE1?M2XG[lExPjl6NEO2
MKN-1M3XOUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7Ml73TWM2OD1yLk[0JO69VQ>?M2jiNVExPjl6NEO2
PC14MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NHHwTplKSzVyPUGuPUDPxE1?MoDGNVA3QTh2M{[=
T24M2joZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MULJR|UxRTBwNkSg{txOM1nDZVExPjl6NEO2
U937Mm\SSpVv[3Srb36gRZN{[Xl?NX\TZlB2OjRiaB?=MXLEUXNQNH3LNFlKdmirYnn0d{BqdmOxcoDvdoF1cW:wIH;mJHs{UF22aIntbYRqdmVid3n0bEBKSzVyIH;mJFAvOSEQvF2=M1O5ZVExPzhyOUGx
H460pv8/etoNX3yZ2RpS3m2b4TvfIlkKEG|c3H5MkPsNVAxKM7:TR?=Mo\aOFghcA>?MlHYV4FtcW6nM3nUbWlEPTB;MD6wNkDPxE1?MoS1NVA4QDB7MUO=
H460pv8M4P4VWN6fG:2b4jpZ{BCe3OjeR?=NHLMO4IyODBizszNM3;UfFQ5KGh?NUXNNXJJW2GuaX7lNYPUfYtYUUN3ME2wMlAxPCEQvF2=Mle3NVA4QDB7MUO=
MDA-231NIDNU25EgXSxdH;4bYMhSXO|YYm=NX7kfI4yOTByIN88US=>NEHNXpQ1QCCqMmXBV4FtcW6nM4rRdGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KE2GQT2yN|Eh[2WubDCoSXIuNEWJRmKrMI12fGGwdDDwOVMqKHerdHigTWM2OCCxZjCwMlAxPiEQvF2=MlrLNVA4QDB7MUO=
MDA-468NFGxSotEgXSxdH;4bYMhSXO|YYm=NGTTelUyODBizszNNIXPPGM1QCCqMlL5V4FtcW6nM3\XVWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KE2GQT20Olgh[2WubDCoSXIuNCCjbYDsbYZq\WRiRVfGVkwhdXW2YX70JJA2Oylid3n0bEBKSzVyIH;mJFAvODB3IN88US=>M1n6NVExPzhyOUGz
NCI-H226NHzGV3pEgXSxdH;4bYMhSXO|YYm=MY[xNFAh|ryPMkDsOFghcA>?NYn4elltW2GuaX7lM{DJSGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KE6FST3INlI3KGOnbHygLI12fGGwdDDwOVMqKHerdHigTWM2OCCxZjCwMlAxQCEQvF2=NUjLS3YyOTB5OEC5NVM>
NCI-H322NYHMVI5nS3m2b4TvfIlkKEG|c3H5M3HK[VExOCEQvF2=NIPJZog1QCCqMlz3V4FtcW6nNXTYXWNtS3m2b4TvfIlkcXS7IHHnZYlve3RiTlPJMWg{OjJiY3XscEApdXW2YX70JJA2Oylid3n0bEBKSzVyIH;mJFAvODNizszNNWTzTmtNOTB5OEC5NVM>
NCI-H358MnjOR5l1d3SxeHnjJGF{e2G7Mlf4NVAxKM7:TR?=M4XCb|Q5KGh?M4q4V3NidGmwZR?=M2SzbGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KE6FST3IN|U5KGOnbHygLI12fGGwdDDwOVMqKHerdHigTWM2OCCxZjCwMlE{KM7:TR?=M3PhcFExPzhyOUGz
NCI-H647M4XZfGN6fG:2b4jpZ{BCe3OjeR?=NVnnbW9WOTByIN88US=>NH;oOFQ1QCCqM3zLdnNidGmwZR?=NUW4d2lIS3m2b4TvfIlkcXS7IHHnZYlve3RiTlPJMWg3PDdiY3XscEApdXW2YX70JJA2Oylid3n0bEBKSzVyIH;mJFAvODBzIN88US=>MnuwNVA4QDB7MUO=
SKBR-3MVzDfZRwfG:6aXOgRZN{[Xl?M1rRd|ExOCEQvF2=M2H3UFQ5KGh?MnjlV4FtcW6nNXXye4VUS3m2b4TvfIlkcXS7IHHnZYlve3RiU1vCVk0{KGOnbHygLGVTNWGvcHzp[olm\CCnclKyMI12fGGwdDDwOVMqKHerdHigTWM2OCCxZjCwMlAzKM7:TR?=MoXvNVA4QDB7MUO=
T47DNW\LbFBKS3m2b4TvfIlkKEG|c3H5M{jvUFExOCEQvF2=M2rUOlQ5KGh?MX\TZYxqdmV?M{DRPGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KFR2N1SgZ4VtdCBqRWKrMI12fGGwdDDwOVMqKHerdHigTWM2OCCxZjCwMlAxPyEQvF2=NF7ES4UyODd6MEmxNy=>
ZR-75-1M17BWWN6fG:2b4jpZ{BCe3OjeR?=MlL3NVAxKM7:TR?=M3Px[|Q5KGh?MX\TZYxqdmV?NVTPSoM3S3m2b4TvfIlkcXS7IHHnZYlve3RiWmKtO|UuOSClZXzsJEhGWitucHfyL{xufXSjboSgdFU{MSC5aYToJGlEPTBib3[gNE4xODlizszNMWexNFc5ODlzMx?=
L1210M{nsXWN6fG:2b4jpZ{BCe3OjeR?=MnzWTWM2OD1yLkCyOUDPxE1?MVKxNFg6ODF4Nx?=
D40NYTYU292S3m2b4TvfIlkKEG|c3H5M1L2TlI1KGh?M2f1[mROW09?MULJR|UxRTFwMUeyJO69VQ>?M3HSelExQTV4MkG0
OVCAR-3NX[5cZZQS3m2b4TvfIlkKEG|c3H5MoT4NlQhcA>?MYTEUXNQNX[5cGxxUUN3ME2wMlA{PSEQvF2=NYHSSINXOTB7NU[yNVQ>
UA375NGjp[lFEgXSxdH;4bYMhSXO|YYm=MojCNlQhcA>?MknJSG1UVw>?MmTVTWM2OD1yLkGxNkDPxE1?M1TmTlExQTV4MkG0
CH1MYDDfZRwfG:6aXOgRZN{[Xl?M4HlfVk3KGh?M2XCSGROW09?NXK4ZnBkUUN3ME2wMlAxPjNizszNNW\UcpZxOTFzMkO5PFk>
RENCANFHKSmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MkD2OFghcA>?M2K3UmlEPTB:MD6wNUDPxE1?NX25c|ZJOTF2NUS0Olc>
CNSNVu1VG01T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M1\qS|Q5KGh?NXPHbplHT0l3ME2wMlA3PCEQvF2=M4HSRVEyPDd|NEG4
J82M4LkZWN6fG:2b4jpZ{BCe3OjeR?=NEfscYkyOCEQvF2=M{L1TWROW09?MWfDfZRwfG:6aXPpeJkh[WejaX7zeEBLQDJic3Xud4l1cX[nIHPlcIwhf2m2aDDJR|UxKG:oIECuNFMh|ryPNGDZZ2MyOTZyNkG0NS=>
LoVoNEC5UYpEgXSxdH;4bYMhSXO|YYm=M1nDb|ExKM7:TR?=MoTXSG1UVw>?M2n3XWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KEyxVn:gd4Vve2m2aY\lJINmdGxid3n0bEBKSzVyIH;mJFAvODB6IN88US=>NYPpNIlIOTF4ME[xOFE>
T24MnnkR5l1d3SxeHnjJGF{e2G7MUGxNEDPxE1?M4fqO2ROW09?NIP1d3hEgXSxdH;4bYNqfHliYXfhbY5{fCCWMkSgd4Vve2m2aY\lJINmdGxid3n0bEBKSzVyIH;mJFAvODJizszNM1[xd|EyPjB4MUSx
U373NYDXXmNzS3m2b4TvfIlkKEG|c3H5NWS2PItWOTBizszNM1;ubGROW09?M3KzWWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KFV|N{Ogd4Vve2m2aY\lJINmdGxid3n0bEBKSzVyIH;mJFAvODFizszNMnfONVE3ODZzNEG=
U87MVjDfZRwfG:6aXOgRZN{[Xl?M4S4d|ExKM7:TR?=MWLEUXNQNVzZVGNyS3m2b4TvfIlkcXS7IHHnZYlve3RiVUi3JJNmdnOrdHn2[UBk\WyuIIfpeIghUUN3MDDv[kAxNjB4IN88US=>NE\hZW4yOTZyNkG0NS=>
U87NUPaVnE2S3m2b4TvfIlkKEG|c3H5MmezNVAh|ryPM4DCcGROW09?M4G0VGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KFV6NzDy[ZNqe3SjboSgZ4VtdCC5aYToJGlEPTBib3[gNE4yPCEQvF2=MVWxNVYxPjF2MR?=
UACC62M2HkU2N6fG:2b4jpZ{BCe3OjeR?=NHrHT2o{NTVibR?=MVLEUXNQNX:xPG81T0l3ME2wMlA6PCEQvF2=NUD2[4k2OTF4N{i2OFk>
SKVLB1M3PtcWN6fG:2b4jpZ{BCe3OjeR?=NVHic2dbPzJiaB?=MV3EUXNQNWfEOodCS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hdXWudHnkdpVoNXKnc3nzeIFvfCCVS2\MRlEh[2WubDD3bZRpKEmFNUCgc4YhOi5{IN88US=>NGf0cmYyOTd3NE[wNi=>
HCT116M4jVemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NWWwWWdXT0l3ME2wMlAzOyEQvF2=NVjyTFVqOTF5NUWzOlM>
COR-L23MoryR5l1d3SxeHnjJGF{e2G7NEi0SIE2NTZiZB?=NILtcolKSzVyPUCuNFIxOSEQvF2=M4f5WFEyQDB4N{K0
H69PNE[0R5ZEgXSxdH;4bYMhSXO|YYm=MUK1MVYh\A>?NFzicYlKSzVyPUCuNFI4OyEQvF2=NUTr[2VpOTF6ME[3NlQ>
H69/LX4Mm\TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NVjhPIR7PCCmNWjofHpYUW6qaXLpeI9zgSCjY4Tpeol1gSCjZ3HpcpN1KGS{dXegdoV{cXO2YX70JGg3QS:OWESgZ4VtdCCxdnXy[ZhxemW|c3nu[{BRNWeueXPvdJJwfGWrbjD3bZRpKEmFNUCgc4YhOC5zM{eg{txONXeze3BqOTF6ME[3NlU>
H69PMkDLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MVm0JIQ>M3LYU2lEPTB;MD6wNlch|ryPM1m3OFEyQDB4N{K1
U251MkjvR5l1d3SxeHnjJGF{e2G7MXLJR|UxRTBwMEmg{txOM2qx[|EzODN7NUi4
UMUC3NWOxUZNjS3m2b4TvfIlkKEG|c3H5MX7JR|UxRTBwMEC5NkDPxE1?NV;FUZR2OTJ|OUK3Nlc>
CRL7065NEniXJZEgXSxdH;4bYMhSXO|YYm=M4ewT|Yh\A>?NXTOUYZ{TE2VTx?=M4X3WWlEPTB;MD61JO69VQ>?M3vFT|EzPDNzMES4
SKMEL-28NHnVPZpEgXSxdH;4bYMhSXO|YYm=NUm2dJlvPiCmMV;EUXNQMojMTWM2OD1yLkC2JO69VQ>?MYSxNlQ{OTB2OB?=
SK-MES-1NH\HOmtEgXSxdH;4bYMhSXO|YYm=MmHLOkBlM1;6ZWROW09?NWHPWnAyUUN3ME2wMlA{KM7:TR?=M3;kNVEzPDNzMES4
Hep-2NGm0RVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M{fxeVk3KGh?MULEUXNQM4jlWGlEPTB;MD6wOEDPxE1?MlflNVI1OzFyNEm=
RajiMlXrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MYW5OkBpNEXiSY5FVVORMXPJR|UxRTBwMEOg{txONU[2[FFZOTJ2M{GwOFk>
Wil-NSM37xbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MVq5OkBpMlPSSG1UVw>?MVzJR|UxRTBwMEKg{txONYnqdmZ1OTJ2M{GwOFk>
2SC/20Mn70S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MmmxO|IhcA>?M1riPIRmcW:waYrl[EB4[XSnch?=MXfJR|UxRTBwNkKg{txOM2fvUFEzPDNzME[w
HET-SR-2SC-LNMM1rJeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M3X4TVczKGh?MWDk[Ylwdmm8ZXSge4F1\XJ?NWrNU3pxUUN3ME2wMlA2OiEQvF2=M{PqUFEzPDNzME[w
L1210M332UWN6fG:2b4jpZ{BCe3OjeR?=NULpb4dnPDhiaB?=MY\EUXNQNEPRR2hKSzVyPUCuNFI2KM7:TR?=NI\IdXkyOjR2M{e2Ny=>
LXFL529NI\2V4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MX6zOkBpNXnQW4dUUUN3ME2wMlA1KM7:TR?=NIjKV5MyOjR3OUCyNC=>
8226/DOX1VNUjxW2xtS3m2b4TvfIlkKEG|c3H5M4S4VVczKGh?M3G3e2ROW09?MWHDfZRwfG:6aYT5JIFo[Wmwc4SgPFIzPi:GT2ixWi=>Mn3BNVI2PzB|N{i=
8226/SMnq2R5l1d3SxeHnjJGF{e2G7NIDQcnc4OiCqMX\EUXNQNWLwV3BYS3m2b4TvfIl1gSCjZ3HpcpN1KDh{Mk[vVy=>M2LUeVEzPTdyM{e4
JurkatNYfJOnZLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NHHkfo84OiCqMmrjTWM2OD1yLkCwPVYh|ryPNYPHbJg5OTJ4MkCwPFE>
P388M1nlR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MUm3NkBpM1zJ[2lEPTB;MD6wNVUh|ryPM4PJU|EzPjJyMEix
L2987NV\ycXJsS3m2b4TvfIlkKEG|c3H5M132O2lEPTB;MD6zJO69VQ>?NGfoPJoyOjd7OEOxOy=>
401NLMonIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MnnSO|IhcA>?NXXlWFRHTE2VTx?=MkfLTWM2OD1yLkCxJO69VQ>?NI\ucY0yOjh3Mke2PC=>
LXF529LNGLH[HhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NHrFeI44OiCqNEGzcodFVVORNVTYZZdMUUN3ME2wMlA{KM7:TR?=NYnsUmxROTJ6NUK3Olg>
LXF629LMXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MlLaO|IhcA>?MYLEUXNQNEHGfmZKSzVyPUCuNFch|ryPM17JUlEzQDV{N{[4
RXF944LNV3SV|RPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M{\4cFczKGh?NHvDXmdFVVORNV\hSohWUUN3ME2wMlA3KM7:TR?=MXqxNlg2Ojd4OB?=
Neuro2AMnj6SpVv[3Srb36gRZN{[Xl?M4fGUlMhfWdxbVy=NF32fXEzPCCqNIi4VXlP\XW{aYTv[4VvcWNiYXP0bZZqfHliYYPz[ZN{\WRiYYOgcY9zeGixbH;nbYNidCClaHHu[4V{MVOxOFU4PTR2MB?=
HT1080MmnvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NF3GU4Q4OiCqNXjSeVRJTE2VTx?=NIfhU3NKSzVyPUCuNFU6KM7:TR?=NF7ZNG0yPDZ2MEWxNy=>
H460MoPmR5l1d3SxeHnjJGF{e2G7MVrHTVUxRTNwMPMAjeOY6oDLMUCtO{DPxGdxbVy=M3vlcVE1PjRyNUOy
MCF7NU\mSGhWS3m2b4TvfIlkKEG|c3H5M2TXT2dKPTB;OD6w5qCKy5gkgJmxNE04KM7:Zz;tUC=>M{L0RlE1PjRyNUOy
SF268MlrwR5l1d3SxeHnjJGF{e2G7NInkV4NIUTVyPUiuOgKBkcPZ4pEJNVAuPyEQvHevcWw>NHLiWJMyPDZ2MEWzNi=>
DuPROMnjaR5l1d3SxeHnjJGF{e2G7MlfQSWM2OD1zLkig{txOMYexOFY3PzJyOB?=
DU145MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MnzSO|IhcA>?NHj1fVdFVVORMWHHTVUxRTBwMEKg{txOMlPnNVQ6PzF6OUO=
HeLaM4f6UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NVvQZWxIPzJiaB?=M{LOVGROW09?NELHN2hIUTVyPUCuNFEh|ryPMo\DNVQ6PzF6OUO=
IGROVM3;TfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7Mlv1O|IhcA>?NGn2N3dFVVORM1vYR2dKPTB;ND60JO69VQ>?MVKxOFk4OTh7Mx?=
LNcaPM3P4XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7Ml\lO|IhcA>?NUPqXowyTE2VTx?=Ml3qS2k2OD1yLkCyJO69VQ>?MUGxOFk4OTh7Mx?=
LOVOMmHVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MXq3NkBpNGjPNYdFVVORM2PFfmdKPTB;MD6wNUDPxE1?NGjs[W8yPDl5MUi5Ny=>
MEL-28MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MUS3NkBpNIDHNolFVVORNYLOXXFLT0l3ME2zMlEh|ryPNVe4VoJyOTR7N{G4PVM>
PANC-1M13lfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MWK3NkBpNHTO[m5FVVORNUnPT206T0l3ME2zMlUh|ryPNELsbmUyPDl5MUi5Ny=>
MDA-MB-435NXnoR|RlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MXG0JIg>NWfJS5FQTE2VTx?=MlPxTWM2OD1yLkG1JO69VQ>?NUTI[3k2OTR7N{G4PVk>
TRAMP-C2DMYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MXO3NkBpM3Xwb2lEPTB;MD6wOFY2KM7:TR?=NUfJc|dKOTR7N{G5NVA>
TRAMP-C2GNEC3[25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NFe5W3k4OiCqMkjJTWM2OD1yLkCyPFch|ryPNVW0[YlSOTR7N{G5NVA>
MD-MB468NF;UXppEgXSxdH;4bYMhSXO|YYm=NUTlbHY6PzJiaB?=MnG0TWM2OD1yLkCwO{DPxE1?NGrnSm4yPDl6ME[3Ni=>
T47DNWDlWnlPS3m2b4TvfIlkKEG|c3H5MWW3NkBpM2rvfWlEPTB;MD6wNFch|ryPMlnENVQ6QDB4N{K=
RPMI8226MnfYR5l1d3SxeHnjJGF{e2G7MX23NkBpMYTJR|UxRTBwMTFOwG0>MYOxOFk5PzB2OR?=
U937/GTBMX3DfZRwfG:6aXOgRZN{[Xl?M1jyU|czKGh?NWPGSIVoUUN3ME2wMlEh|ryPMnmzNVQ6QDdyNEm=
Col2NU\PSIdQS3m2b4TvfIlkKEG|c3H5MXy3NkBpMXzEUXNQNHjDTWhKSzVyPUCuOVIh|ryPMoDKNVUyPzd2M{i=
MEL-28M13VdGN6fG:2b4jpZ{BCe3OjeR?=M3jyPWlEPTB;MD6wN{DPxE1?NF;EdIYyPTJ{NUewNC=>
Rtx6MoXlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MlK4OEBpM{XCeWROW09?MlvnS5Jwf3SqIHnubIljcXSrb36gc4YhTVJiZYjwdoV{e2mwZzDSeJg3KGOnbHzzNVXxbVl{OTV3OEiwPFY>
WI38MlL3R5l1d3SxeHnjJGF{e2G7NFrDd|k1QCCqNIrJ[4lFVVORMmjjTWM2OD1yLkOg{txOMkOxNVU3OjB{M{i=
MeVoM2PLXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MYiyOEBpM3m4[JdifGW{M2PaZWlEPTB;MD64NkDPxE1?NUjCRlRZOTV5MUW0PFE>
VA13NELBZlJEgXSxdH;4bYMhSXO|YYm=MnvEOFghcA>?MWTEUXNQNXv6V|JpUUN3ME2wMlM5KM7:TR?=NVf4UXRLOTV5M{CyOFM>
NCI-H69MYfDfZRwfG:6aXOgRZN{[Xl?Mn7HOkBlM3\JXGlEPTB;MD6wNVE{KM7:TR?=MonoNVU4PDNzN{i=
HSC-2MkHyR5l1d3SxeHnjJGF{e2G7MYeyOEBpNVnBTnJyS0N3ME2wMlY5KM7:TR?=NUKzPVlIOTV5NEW4NVI>
HSGNVixclJ[S3m2b4TvfIlkKEG|c3H5MViyOEBpNXfneFJFS0N3ME2xMlkh|ryPNEfCdGYyPTd2NUixNi=>
MES-SAM1rQW2N6fG:2b4jpZ{BCe3OjeR?=MVzJR|UxRTBwMEG2JO69VQ>?NHnkNpIyPjF4OUexPS=>
MESSA/DX5MojiR5l1d3SxeHnjJGF{e2G7MlPmR5l1d3SxeHnjbZR6KGGpYXnud5QhdXWudHnkdpVoNXKnc3nzeIFvfCCPRWOtV2EwTHh3IHPlcIx{KHerdHigTWM2OCCxZjCxMlU3KM7:TR?=NWfXVnY4OTZzNkm3NVk>
VA13NGXxbW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NEnXVoE1QCCqMoroSG1UVw>?MmnQTWM2OD1yLkKyJO69VQ>?M4q2NlE3PDl7M{Ky
MCF7Mnv2SpVv[3Srb36gRZN{[Xl?M1PzflAvPSEQvHevcWw>M1K0XVI1KGh?NIrVbnZFVVORNULmdWo5UW6qaXLpeIlwdiCxZjDwOVMudWWmaXH0[YQhfHKjboPhZ5RqfmG2aX;uMXuxOlg3OjF2MR?=
5637M4\lbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NFLsV2w6PiCqNIX3cWhFVVORMo\VTWM2OD1yLkCyJO69VQ>?M{HsO|E3QTF|N{Cw
ACHNMXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NIHrN4k6PiCqNXLBfFBTTE2VTx?=MlTaTWM2OD1yLkCwNUDPxE1?NFvIRoIyPjlzM{ewNC=>
C8166MnfBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M2XYdVk3KGh?M1\lXGROW09?NXvIOG56UUN3ME2wMlAzKM7:TR?=NFvwTGIyPjlzM{ewNC=>
G361MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NFy4bFA6PiCqM2LScGROW09?MlnCTWM2OD1yLkC5JO69VQ>?Mm\nNVY6OTN5MEC=
Wil2-NSNHPjRoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M2PvZ|k3KGh?NUHITVNHTE2VTx?=MXzJR|UxRTBwMEKg{txOMWixOlkyOzdyMB?=
BCMXzDfZRwfG:6aXOgRZN{[Xl?NYjEXlgyUUN3ME2wMlI5QCEQvF2=MUWxOlk{Ozh7MB?=
HL60/ADRMVzDfZRwfG:6aXOgRZN{[Xl?MXuxJI1OM{noUVczKGh?NV:zPXRVTE2VTx?=MUfDfZRwfG:6aXPpeJkh[WejaX7zeEBi\HKrYX35Z4lvNXKnc3nzeIFvfCCKTE[wM2FFWiClZXzsd{BmgHC{ZYPzbY5oKE2UUEGge4l1cCCLQ{WwJI9nKDJizszNM2LZfVE4ODZ7OUO0
HA22TMXvDfZRwfG:6aXOgRZN{[Xl?NU\LOVU{PzJiaB?=NIrDSGFFVVORM{nwV2lEPTB;MD6zNUDPxE1?MojoNVcyODd6ME[=
AGSMVnDfZRwfG:6aXOgRZN{[Xl?MnrETWM2OD1yLkOxJO69VQ>?M4rySlE4OTJ3MkSw
H9c2M4m3V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NGjld4YzPCCqNHXDN3JFVVORM3XvbmlEPTB;MD6wNVk6PSEQvF2=Ml;sNVcyOjV{NUO=
SHP77M1\UOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M{T6XlI1KGh?NXjlXphKTE2VTx?=NXjTWVdoUUN3ME2wMlEzPTh7IN88US=>NFL3UW0yPzF{NUK1Ny=>
SK-HEP-1MojHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NYL5ZmFVOjRiaB?=M1LQbWROW09?NFj6NIxKSzVyPUCuNFUxOTJizszNNX\RUZp2OTdzMkWyOVM>
VeroM4LmPWN6fG:2b4jpZ{BCe3OjeR?=NFPCcZUzPCCqM2m0[2ROW09?Ml7tTWM2OD1yLkWwNVE6KM7:TR?=M1HEW|E4OTJ3MkWz
A2780MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NFq2RlkyKM7:TR?=Ml3qOEBlNHTQTHZFVVORMUHJcohq[mm2aX;uJI9nKGOrc4DsZZRqdi2{ZYPpd5RidnRiQUK3PFAh[2WubDDndo94fGhid3n0bEBKSzVyIH;mJFAvODB|IN88US=>NFTVO4cyPzF{NUK1OC=>
A2780Mo\DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NEXPOYEyKM7:TR?=MWq0JIQ>M3\qOWROW09?NIHqV3BKdmirYnn0bY9vKG:oIHTvfI9zfWKrY3nuMZJme2m|dHHueEBCOjd6MDDj[YxtKGe{b4f0bEB4cXSqIFnDOVAhd2ZiMD6wOlEh|ryPMkfMNVcyOjV{NUS=
MDA-MB-231MYLDfZRwfG:6aXOgRZN{[Xl?NGf3dWo4OiCqM2LuWWROW09?Mo\QTWM2OD1yLkCzJO69VQ>?NXPCSXFPOTdzNEG5NlM>
MDA435/LCC6NIDle3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NWnQbpNyPCCmNGnWWGdFVVORNVXNN3M2UUN3ME2wMlMh|ryPM3S3c|E4OTV2NUC1
K562MlrJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MXW0PEBpMUHEUXNQN22ndHjhco9tMWHJR|UxRTBwMEGg{txONHz0UWQyPzF6MUG2OC=>
TRAMP-C1ANHLkU25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M3i5Z|czKGh?M{jDU5difGW{M2jTPGdKPTB;MD6wNlA1KM7:TR?=MUSxO|E5OTF4Nh?=
TRAMP-C2HMXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NIrWUXc4OiCqM1fXVZdifGW{NVL0OJJJT0l3ME2wMlAyPThizszNMUixO|E5OTF4Nh?=
2780ADNFXzRlNEgXSxdH;4bYMhSXO|YYm=NGj0O|AyOCEQvF2=NI\YNJJEgXSxdH;4bYNqfHliYXfhbY51KG23bITp[JJ2\y2{ZYPpd5RidnRiaIXtZY4hOjd6MFHEJINmdGy|IIfpeIghUUN3MDDv[kAxNjlyOTFOwG0>NGOyT|UyPzJ|OUW5Oy=>
K562I/S9NIPzSnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NIroXGg4OiCqM17mOmROW09?NIXq[mZCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIH31cJRq\HK3Zz3y[ZNqe3SjboSgT|U3OmlxU{mgZ4VtdHNiZYjwdoV{e2mwZzDQ[5Ahf2m2aDDJR|UxKG:oIEKg{txOMoHDNVczPzZ4OUC=
CEM/VLB100NXe2bHdYS3m2b4TvfIlkKEG|c3H5NI\Q[I84OiCqNIjFPGhFVVORMVjDfZRwfG:6aXPpeJkh[WejaX7zeEB3cW6kbHHzeIlv\S2{ZYPpd5RidnRiQ1XNM3ZNSjFyMDDj[YxteyC5aYToJGlEPTBib3[gN{44OSEQvF2=NFPNeW0yPzN{M{mzPS=>
CEM/VM1NXnJXlJQS3m2b4TvfIlkKEG|c3H5NUD3Noh1PzJiaB?=NHTUN2RFVVORNHvPT5dEgXSxdH;4bYNqfHliYXfhbY5{fCC2ZX7pdI9{cWSnLYLld4l{fGGwdDDDSW0wXk1zIHPlcIx{KHerdHigTWM2OCCxZjCwMlU2KM7:TR?=NVXTNplOOTd|MkO5N|k>
MeVoM1jPWmN6fG:2b4jpZ{BCe3OjeR?=M2\xPFQ5KGh?Mki5e4F1\XJ?M{XLN2lEPTB;MD64NkDPxE1?NF3CcZIyPzN5NUmwNi=>
KB-VINM2eyc2N6fG:2b4jpZ{BCe3OjeR?=M1m2eVczKGh?MnPCSG1UVw>?MVTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDteYx1cWS{dXetdoV{cXO2YX70JGtDNV[LTjDj[YxteyC5aYToJGVEPTBib3[gNU44KM7:TR?=MkHhNVc{Pzh3M{C=
2780ADMoXxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NU\sdpN1OTBizszNNWO4Sm9HT3Kxd4ToJIlvcGmkaYTpc44hd2ZibYXseIllenWpLYLld4l{fGGwdDDoeY1idiB{N{iwRWQh[2WubIOge4l1cCCLQ{WwJI9nKDBwMkm4JO69VQ>?MVyxO|Q6ODh5OB?=
BGC823NFvBZnhEgXSxdH;4bYMhSXO|YYm=Ml7TOFghcA>?MoTtTWM2OD1yLkO1JO69VQ>?NGnpN5EyPzV6M{m1Ny=>
ZR-751MoPLR5l1d3SxeHnjJGF{e2G7MXm3NkBpNIK2OoFFVVORMVfJR|UxRTBwMESg{txOM{W0UlE4PTh3N{S3
1A9NHPESItEgXSxdH;4bYMhSXO|YYm=M3;m[2ROW09?NGn5e5VGTDVyPUCuNFIh|ryPNGK2Wo8yPzV7MUS0OC=>
LNcaPNVvHW5UxS3m2b4TvfIlkKEG|c3H5MYrEUXNQM3jZfWVFPTB;MD6wOEDPxE1?MX2xO|U6OTR2NB?=
UACC62Mo\6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MXi0PEBpNYjCbHFVTE2VTx?=MVPHTVUxRTBwMEm0JO69VQ>?Mo\lNVc3OTR{OUK=
DLD1NEToUGlEgXSxdH;4bYMhSXO|YYm=M2K3[|czKGh?NYrNUlhsUUN3ME2wMlEh|ryPNVTONpFGOTd4NU[wPVE>
UO31NX74fJFxS3m2b4TvfIlkKEG|c3H5MVe3NkBpNIrXcoJKSzVyPUCuNUDPxE1?NFXpcHgyPzZ3NkC5NS=>
PC3M3;5OWZ2dmO2aX;uJGF{e2G7MlSzNlAhdk1?MnTCO|IhcA>?Mlu1TY5lfWO2aX;uJI9nKHOnbnXzZ4Vv[2ViaX6gbJVu[W5iUFOzJINmdGy|NVixXZdYOTd4NUi3O|c>
BxPc3MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MnfqN{BpMWrJR|UxRTBwM{G2NlMh|ryPMl65NVc3QTZ3MU[=
IGROVIM17xeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NInGXnA1QCCqM1rMZWlEPTB;MD6xNFk3PSEQvF2=NUn5OII4OTd4OU[1NVY>
RXF393MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NEXCdnM1QCCqMlLNTWM2OD1yLkG3O|g{KM7:TR?=MWKxO|Y6PjVzNh?=
UACC257NYPxT|FXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NVnmc2JNPDhiaB?=NV3QUldQUUN3ME2wMlIxQDl|IN88US=>M12xNFE4Pjl4NUG2
MIAPaCa2M4fxXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MYOxNFAh|ryPMWW3NkBpNXHCZlFXUUN3ME2wMlAzPCEQvF2=MW[xO|k{PTNyOR?=
WI38NEjXZllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NVrwNZQ5OTByIN88US=>NH\6PWY4OiCqNYfnZ|B3UUN3ME2wMlEh|ryPM130[|E4QTN3M{C5
KB3.1NVTsU413T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NX\rNFVyOTByIN88US=>M3LuOFczKGh?NFHj[WlFVVORMlm1TWM2OD1yLkCwNFQh|ryPNXjBZ4tbOTd7NEm4OVk>
MCF7MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NGTtXYsyODBizszNMUi3NkBpMnm4SG1UVw>?MYDJR|UxRTBwMECwO{DPxE1?NYLIWGtLOTd7NEm4OVk>
2780.9SMoroR5l1d3SxeHnjJGF{e2G7NGHQO2wyODBizszNM{jy[|k3KGh?MXHDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjCyO|gxNjmVIHPlcIx{KHWwZHXyJIRm\W1ibHnnbJQhf2m2aDDJR|UxKG:oIEG1JO69VQ>?MnvYNVc6QTN{N{W=
DaudiNIjONmVEgXSxdH;4bYMhSXO|YYm=NUexPZQzOTByIN88US=>Mn;4PVYhcA>?MnS1R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gSIF2\GliY3XscJMhfW6mZYKg[IVmdSCuaXfoeEB4cXSqIFnDOVAhd2ZiMD6zJO69VQ>?M1jNRVE4QTl|Mke1
W301MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NGnnd4s2OCCvTR?=NELrbVk1QCCqMlvISG1UVw>?MYrHdo94fGhiaX7obYJqfGmxbjDv[kBU[WOlaHHyc416[2W|IHPldoV3cXOrYXWgW|MxOSC5aYToJGlEPTBib3[gNVAh|ryPMnLCNVgxPDByNEO=
SF268M1[3N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MojHO|IhcA>?NULjPVVzTE2VTx?=NX;pVWhYUUN3ME2wMlA1KM7:TR?=NYrGPZZ1OThyNUKzNlY>
SNU638MoXCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NHrwPG04OiCqM120fGlEPTB;MD6wO{DPxE1?MVOxPFA3OzN4Nh?=
U373MGNW\HNGhuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MXWyOEBpNUfRPGVLTE2VTx?=MXLHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDVN|c{VUdiY3XscJMh[2:wdHHpcolv\yCXM{ezTXJGWyCybHHzcYllKHerdHigTWM2OCCxZjCwMlE2QDR7IN88US=>NYj0PYtlOThzN{OyN|M>
U373MGMnvXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NFHRZoozPCCqMkG0SG1UVw>?M4\wbGdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJHU{PzOPRzDj[YxteyClb370ZYlvcW6pIGXoR2UyKGW6cILld5NqdmdicHzhd41q\CC5aYToJGlEPTBib3[gNE4yPTh2OTFOwG0>NEfFdmIyQDF5M{KzNy=>
U373MGM2LuUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NGryfnYzPCCqM{HsUmROW09?NXnLV4dLT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hXTN5M13HJINmdGy|IHPvcpRicW6rbnegWYhqS0ViZYjwdoV{e2mwZzDwcIF{dWmmIIfpeIghUUN3MDDv[kAxNjF7OUWzJO69VQ>?M{[y[|E5OTd|MkOz
HepG2NVLBT|N7S3m2b4TvfIlkKEG|c3H5NUT1RVNCOTByIN88US=>MYC3NkBpNXj0cXl3UUN3ME2wMlA4KM7:TR?=NITONpcyQDF6MUW3OS=>
SJSA1MYTDfZRwfG:6aXOgRZN{[Xl?M1;HO|Eh|ryPMVq2JIg>M3y2U2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHNLW0FzIHPlcIx{KGW6cILld5NqdmdiR2LQO|ghf2m2aDDJR|UxKG:oIECuNFA3OiEQvF2=MUWxPFI1OzZ7Nh?=
PC3MM3u4Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NWXvWGhQPzJiaB?=Mn;pSG1UVw>?NFXEcGdKSzVyPUGuNVEh|ryPM1zQbVE5OjR5NUez
K/VP.5NFvSN|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MXe3NkBpNVvqNJo4TE2VTx?=NFOweXdIem:5dHigbY5pcWKrdHnvckBw\iCndH;wc5Nq\GVvcnXzbZN1[W62IHj1cYFvKEtxVmCuOUBk\WyuczD3bZRpKEmFNUCgc4YhOC52MTFOwG0>NF\UXHAyQDJ3OES0Ni=>
A375NH7Zc4REgXSxdH;4bYMhSXO|YYm=NXLrd|ExOjRiaB?=NFzYR4tFVVORMm\xTWM2OD1yLkCxJO69VQ>?M3m4bFE5OjhzMUK1
Hep2MlPkR5l1d3SxeHnjJGF{e2G7NVfwS|hLOjRiaB?=NFTuTZdFVVORMlPiTWM2OD1yLkSyJO69VQ>?NGfDOXcyQDJ6MUGyOS=>
HT1080MlP5R5l1d3SxeHnjJGF{e2G7NX32SHQ1PzJiaB?=MnniSG1UVw>?NYfLfJBlUUN3ME2wMlAzOiEQvF2=MnztNVg{OjF5MUW=
SNU638M4C5WGN6fG:2b4jpZ{BCe3OjeR?=MVq3NkBpMW\EUXNQNHq4eXlKSzVyPUCuNFUzKM7:TR?=NVjTcWh2OTh|MkG3NVU>
Caco2NYrVN3l7TnWwY4Tpc44hSXO|YYm=MlH0OVAhdk1?M4TpVFQ5KGh?Mojwe4F1\XJ?M4nmRmRm[3KnYYPlJIlvKGO7Y3zpckBCKGW6cILld5Nqd25?M3ziV|E5PDJ7NkGw
MCF7/DXMoPyR5l1d3SxeHnjJGF{e2G7MkSwNlQhcA>?MWj3ZZRmeg>?MWrDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDkc5hwenWkaXPpck1z\XOrc4ThcpQhVUOINz;EfEBk\WyuczD3bZRpKEmFNUCgc4YhPS5|IN88US=>NFrh[oIyQDR{OU[xNC=>
Colon 26-L5Mkf3R5l1d3SxeHnjJGF{e2G7MYm3NkBpNFrwPZdFVVORNVnBR|hCUUN3ME2wMlAyKM7:TR?=MnzwNVg1PDB{M{O=
LLCM1:0NWN6fG:2b4jpZ{BCe3OjeR?=MUm3NkBpNWP6[XJYTE2VTx?=M3XlfmlEPTB;MD6wNUDPxE1?NX\k[XI5OTh2NECyN|M>
L1210MXPGeY5kfGmxbjDBd5NigQ>?M2jOVFAvPSEQvHevcWw>NFTUeG4yOiCqMnnqe4F1\XJ?NGXFW5ZE\WyuIHP5Z4xmKGG{cnXzeEBqdiCvb4Xz[UBNOTJzMDDj[YxteyCkeTDhZ4N2dXWuYYTpc44h[XRiR{KvUUBxcGG|ZR?=NYC3[Hp1OTh3MEiyO|M>
SK-MEL-2Ml[zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MUK3NkBpNXLYd|VKT0l3ME2wMlEyKM7:TR?=MYixPFU5PTB|NR?=
AW13516NHHQb45EgXSxdH;4bYMhSXO|YYm=NEnRWYsyODBizszNMX20PEBpM1;GUWdKPTB;MD6xJO69VQ>?NEHxVFUyQDZ3N{m3PS=>
AW8507MnLWR5l1d3SxeHnjJGF{e2G7MVSxNFAh|ryPNXPQT2M2PDhiaB?=NUeyUo9ZT0l3ME2wMlE4KM7:TR?=M1LLS|E5PjV5OUe5
JurkatNFq1ZmlEgXSxdH;4bYMhSXO|YYm=NIqzfpY4OiCqNHn4[45KSzVyPUCuNFMh|ryPNUHweXZWOTh5OEO5OVA>
MRC5M1XMfWN6fG:2b4jpZ{BCe3OjeR?=MnHZO|IhcA>?MXnJR|UxRTBwMTFOwG0>Ml3oNVg4QDN7NUC=
DU145MWTDfZRwfG:6aXOgRZN{[Xl?NXXR[YViOjVizsznM41NNEW2OnM4OiCqM2DQTGlEPTB;MD6wNFM6KM7:TR?=MWCxPFgzQTNzNh?=
Bel7402NY\m[3JqS3m2b4TvfIlkKEG|c3H5MXW3NkBpNX7BW3o6TE2VTx?=NV7ENZMyUUN3ME2wMlAzOSEQvF2=MV[xPVAzQDR{NR?=
HT-29MoLwR5l1d3SxeHnjJGF{e2G7MUi3NkBpMmjKSG1UVw>?MmTtTWM2OD1yLkCxPEDPxE1?Mk\SNVkxOjh2MkW=
HT-29M4fSb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NGDGd2w6PiCqNWnVb|U5TE2VTx?=Ml:0TWM2OD1yLkCwNkDPxE1?M37IdFE6ODV|N{[3
MT4Mm\iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NGrVbXg6PiCqMXHEUXNQNVX3ZplbUUN3ME2wMlAxOyEQvF2=Mki2NVkxPTN5Nke=
XF498MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MWe5OkBpMYLEUXNQM2e1VWlEPTB;MD6xOkDPxE1?NInmbGQyQTB3M{e2Oy=>
A2780/DX3NWDi[lZxTnWwY4Tpc44hSXO|YYm=NYnzeXhsOTBizszNM3XyTVIhcA>?NUT2TXVNe2GuaX7lMnOzVoV3\XK|YXygc4YhWC2pcDCxO|AudWWmaXH0[YQhdXWudHnkdpVoKHKnc3nzeIFv[2ViYYPz[ZN{\WRiYYOgbY5kemWjc3WgbY4hcW62cnHj[YxtfWyjcjDkc5hwenWkaXPpckBi[2O3bYXsZZRqd25?NGixSlkyQTB7M{i4Ny=>
HL60MWLDfZRwfG:6aXOgRZN{[Xl?MW[xNFAh|ryPNHjKS4c4OiCqMY\EUXNQMlLvTWM2OD1yLkCxPEDPxE1?NXP3VHR[OTlzM{[yOlM>
Hs888LuMmW1R5l1d3SxeHnjJGF{e2G7NIHpTHU4OiCqM1W0WmlEPTB;MT60JO69VQ>?M2LhelE6OTh4OUS2
MEFNXnKbm9lS3m2b4TvfIlkKEG|c3H5MX:3NkBpMX\JR|UxRTNwNDFOwG0>M2Tkd|E6OTh4OUS2
SNU398NHjrZ3pCeG:ydH;zbZMhSXO|YYm=M{PnPFExKM7:TR?=M{LFTFQ5KGh?M2XrNWROW09?MX\JcoR2[3Srb36gc4Yh[XCxcITvd4l{KGG|c3Xzd4VlKGG|IHPhd5Bie2ViYXP0bZZifGmxbjD3bZRpKEWFNUCgc4YhOC5|OTFOwG0>MXWxPVI5OjF6OB?=
T47DNGrxeJdCeG:ydH;zbZMhSXO|YYm=NIe2d4EyOCEQvF2=NYmyUlQ2PDhiaB?=Mmr5SG1UVw>?NUHFcFdQUW6mdXP0bY9vKG:oIHHwc5B1d3OrczDhd5Nme3OnZDDhd{Bk[XOyYYPlJIFkfGm4YYTpc44hf2m2aDDFR|UxKG:oIECuOVch|ryPNI\GbJYyQTJ6MkG4PC=>
SMMC-7541MoTxR5l1d3SxeHnjJGF{e2G7NHTHWZY4OiCqNHS2VVJKSzVyPUCuNFA{PyEQvF2=NEixVlEyQTJ6NUi2Ny=>
NH32M2fGTGFxd3C2b4Ppd{BCe3OjeR?=M3nJZVAvOSEQvF2=MXW4JIg>MoT1TY5lfWO2aX;uJI9nKGGyb4D0c5NqeyCrbjDwOVMh\GWoaXPp[Y51KGi3bXHuJG5JOzJiY3XscJMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gZ4xm[X[nZDDjZZNx[XOnIEOgcIV3\Wx?MXexPVM1QTF5NB?=
NH32NGDSWW1CeG:ydH;zbZMhSXO|YYm=M{jIblAvOSEQvF2=NH;Ec4k5KGh?NH;CNJFKdmS3Y4Tpc44hd2ZiYYDvdJRwe2m|IHnuJJA2OyCmZX\pZ4lmdnRiaIXtZY4hVkh|MjDj[YxteyCjc4Pld5Nm\CCjczDk[YNz\WG|ZTDpckBxem9vY3HzdIF{\SB|IHzleoVtM{LkWVE6OzR7MUe0
NH32NX3Jc2M2SXCxcITvd4l{KEG|c3H5MWqwMlEh|ryPMYe4JIg>MUnJcoR2[3Srb36gc4Yh[XCxcITvd4l{KGmwIIC1N{Bl\W[rY3nlcpQhcHWvYX6gUmg{OiClZXzsd{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDQRXJRKGOuZXH2ZYdmNXfTbYxHOTl|NEmxO|Q>
NH32NHHaWVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NWK4PYpGOC5zIN88US=>M3XLW|czKGh?NXXHcItIS2WubDDjfYNt\SCjcoLld5QhcW5icEWzJIRm\mmlaXXueEBpfW2jbjDOTFMzKGOnbHzzJIF{e2W|c3XkJIF{KGGlY4XteYxifGmxbjDheEB{fWJvR{CvS|EheGijc3W=M{PVcVE6OzR7MUe0
TK6MX\GeY5kfGmxbjDBd5NigQ>?M4TyPFAvOSEQvF2=Mlz6PEBpMYrJcoR2[3Srb36gc4YheDV|IIDoc5NxcG:{eXzheIlwdiCjdDDT[ZIyPSCrbjDoeY1idiCWS{[gZ4VtdHNiZYjwdoV{e2mwZzD3bYxlKHS7cHWgdFU{NYnxVJVoOTl|NEmxO|Q>
TK6NUThfFhMTnWwY4Tpc44hSXO|YYm=NU[4T25COC5zIN88US=>NX;FZ|MyQCCqMWLJcoR2[3Srb36gc4YheDV|IITyZY5{[3KrcITpc45idCCjY4Tpeol1gSCrbjDoeY1idiCWS{[gZ4VtdHNiZYjwdoV{e2mwZzD3bYxlKHS7cHWgdFU{KGG|c3Xzd4VlKGG|IICyNU1EcXBzL2fh[lEh\XiycnXzd4lwdg>?NEfNd5oyQTN2OUG3OC=>
TK6NHLRe|BCeG:ydH;zbZMhSXO|YYm=M1PoXVAvOSEQvF2=MVi4JIg>MXnJcoR2[3Srb36gc4Yh[XCxcITvd4l{KGmwIHj1cYFvKFSNNjDj[YxteyCneIDy[ZN{cW6pIIfpcIQhfHmyZTDwOVMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gZ4xm[X[nZDDjZZNx[XOnIEOgcIV3\Wx?Mn[0NVk{PDlzN{S=
TK6NF33WVZCeG:ydH;zbZMhSXO|YYm=MY[wMlEh|ryPM1z2XlghcA>?NWnpW2Y{UW6mdXP0bY9vKG:oIHHwc5B1d3OrczDpckBpfW2jbjDUT|Yh[2WubIOg[ZhxemW|c3nu[{B4cWymIIT5dIUheDV|IHHzd4V{e2WmIHHzJIRm[3KnYYPlJIlvKHC{bz3jZZNx[XOnIEOgcIV3\Wx?NEewdo8yQTN2OUG3OC=>
TK6NWrzOGp3SXCxcITvd4l{KEG|c3H5NV\LWmhkOC5zIN88US=>NVLydGJZQCCqMYXJcoR2[3Srb36gc4Yh[XCxcITvd4l{KGmwIHj1cYFvKFSNNjDj[YxteyCneIDy[ZN{cW6pIIfpcIQhfHmyZTDwOVMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gVGFTWCClbHXheoFo\Q>?M2joSlE6OzR7MUe0
TK6MV\GeY5kfGmxbjDBd5NigQ>?NYrK[21tOC5zIN88US=>MkHHO|IhcA>?M1fnS2NmdGxiY4njcIUh[XK{ZYP0JIlvKGi3bXHuJHRMPiClZXzsd{BmgHC{ZYPzbY5oKHerbHSgeJlx\SCyNUOgZZN{\XO|ZXSgZZMh[WOldX31cIF1cW:wIHH0JJN2[i2JMD;HNUBxcGG|ZR?=MkjiNVk{PDlzN{S=
TK6NE\q[IxHfW6ldHnvckBCe3OjeR?=Ml\4NlUh|ryPMWq4JIg>NYqzdHZJUW6mdXP0bY9vKG:oIIC1N{BxcG:|cHjvdplt[XSrb36gZZQhW2W{MUWgbY4hcHWvYX6gWGs3KGOnbHzzJIV5eHKnc4Ppcochf2muZDD0fZBmKHB3Mx?=M3OwTFE6OzR7MUe0
TK6MnnnSpVv[3Srb36gRZN{[Xl?NXfFSZlmOjVizszNNFHMXZM5KGh?MV\JcoR2[3Srb36gc4YheDV|IITyZY5{[3KrcITpc45idCCjY4Tpeol1gSCrbjDoeY1idiCWS{[gZ4VtdHNiZYjwdoV{e2mwZzD3bYxlKHS7cHWgdFU{KGG|c3Xzd4VlKGG|IICyNU1EcXBzL2fh[lEh\XiycnXzd4lwdg>?NETXUZMyQTN2OUG3OC=>
WTK1NV[0O|RjTnWwY4Tpc44hSXO|YYm=NYnUV4VHOC5zIN88US=>NX7OUXRSQCCqMWDJcoR2[3Srb36gc4YheDV|IIDoc5NxcG:{eXzheIlwdiCjdDDT[ZIyPSCrbjDoeY1idiCZVFuxJINmdGy|IHX4dJJme3OrbnegdFU{KE1{M{fJJI12fGGwdB?=MlPXNVk{PDlzN{S=
WTK1MkL5RZBweHSxc3nzJGF{e2G7M1TmTVAvOSEQvF2=MYO4JIg>NXLHbnEyUW6mdXP0bY9vKG:oIHHwc5B1d3OrczDpckBpfW2jbjDXWGsyKGOnbHzzJIV5eHKnc4PpcocheDV|IF2yN|dKKG23dHHueEBie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDjcIVifmWmIHPhd5Bie2ViMzDs[ZZmdA>?MW[xPVM1QTF5NB?=
WTK1NE[4TFBCeG:ydH;zbZMhSXO|YYm=MUWwMlEh|ryPNGi3e4Q5KGh?NUjxdVRtUW6mdXP0bY9vKG:oIHHwc5B1d3OrczDpckBpfW2jbjDXWGsyKGOnbHzzJIV5eHKnc4PpcocheDV|IF2yN|dKKG23dHHueEBie3Onc4Pl[EBieyCmZXPy[YF{\SCrbjDwdo8u[2G|cHHz[UA{KGyndnXsNVrMOYZjOTl|NEmxO|Q>
WTK1Mkf0RZBweHSxc3nzJGF{e2G7MWWwMlEh|ryPM{LNNVghcA>?NUTlbVVnUW6mdXP0bY9vKG:oIHHwc5B1d3OrczDpckBpfW2jbjDXWGsyKGOnbHzzJIV5eHKnc4PpcocheDV|IF2yN|dKKG23dHHueEBie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDQRXJRKGOuZXH2ZYdmNFrKb24yQTN2OUG3OC=>
WTK1NHjmXnhHfW6ldHnvckBCe3OjeR?=NE\iXG4xNjFizszNNVXF[oVuQCCqMkDiTY5lfWO2aX;uJI9nKHB3MzD0doFve2O{aYD0bY9v[WxiYXP0bZZqfHliaX6gbJVu[W5iV2TLNUBk\WyuczDlfJBz\XO|aX7nJJA2OyCPMkO3TUBufXSjboSgZZN{\XO|ZXSgZZMheDJzLVPpdFEwX2GoMTDlfJBz\XO|aX;uNFPIfmkyQTN2OUG3OC=>
WTK1NVryPHhPTnWwY4Tpc44hSXO|YYm=MoLMNlUh|ryPNYraSIppQCCqM3\BPWlv\HWldHnvckBw\iCyNUOgdIhwe3Cqb4L5cIF1cW:wIHH0JHNmejF3IHnuJIh2dWGwIGfUT|Eh[2WubIOg[ZhxemW|c3nu[{BxPTNiTUKzO2khdXW2YX70M{nDfFE6OzR7MUe0
WTK1NIW2WVFHfW6ldHnvckBCe3OjeR?=MnPVNlUh|ryPNIDIbXQ5KGh?M1\ve2lv\HWldHnvckBw\iCyNUOgeJJidnOlcnnweIlwdmGuIHHjeIl3cXS7IHnuJIh2dWGwIGfUT|Eh[2WubIOg[ZhxemW|c3nu[{BxPTNiTUKzO2khdXW2YX70JIF{e2W|c3XkJIF{KHB{MT3DbZAyN1ejZkGg[ZhxemW|c3nvci=>NY\ZOWpjOTl|NEmxO|Q>
WTK1M1TaOWZ2dmO2aX;uJGF{e2G7NYfLdXdxOC5zIN88US=>M3[ze|czKGh?Ml35R4VtdCCleXPs[UBienKnc4SgbY4hcHWvYX6gW3RMOSClZXzsd{BmgHC{ZYPzbY5oKHB3MzDNNlM4USCvdYThcpQh[XO|ZYPz[YQh[XNiYXPjeY12dGG2aX;uJIF1KHO3Yj3HNE9IOSCyaHHz[S=>MlrhNVk{PDlzN{S=
ECV304NWnKOoU5S3m2b4TvfIlkKEG|c3H5MVqxNEDPxE1?Mom1O|IhcA>?Mnv0R5l1d3SxeHnjbZR6Ml3oNVk{PjF6OUS=
HBL100MV7DfZRwfG:6aXOgRZN{[Xl?NF62PYgyOCEQvF2=NWLiRot3PzJiaB?=MoLKTWM2OD1yLkK0JO69VQ>?NUnrd45bOTl|NkG4PVQ>
PA1M1nD[2N6fG:2b4jpZ{BCe3OjeR?=Mn;FNVAh|ryPMX23NkBpMmHOTWM2OD1yLk[zJO69VQ>?NXL4fZpmOTl|NkG4PVQ>
A431NWDFWIpDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MnfLS2k2OD1yLkCwNVIh|ryPM{O2VFE6Ozl2MkG4
A549NVL6NFRGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M3nrUGdKPTB;MD6wNFMh|ryPNIPEcoYyQTN7NEKxPC=>
MESSAMXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NX\RNWNWT0l3ME2wMlAxPTFizszNM3fIR|E6Ozl2MkG4
SKOV3M{XndWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MnzjS2k2OD1yLkCyNUDPxE1?NFrwbpcyQTN7NEKxPC=>
U251NXfxcYJtTnWwY4Tpc44hSXO|YYm=MVWxJO69VQ>?NVrXd5l{OTZiaB?=NGP2e|hFVVORNVTJV4lrUW6qaXLpeIlwdiCxZjDITWYyKGGldHn2ZZRqd25iaX6gbJVu[W5iVUK1NUBk\WyuczDzeIFjdHlidILhcpNn\WO2ZXSgbY4heEeOMj3UT{1JWkVicHzhd41q\CC5aYToJGVEPTBib3[gNE4yOiEQvF2=NV;WeVFpOTl2MEW1NFg>
MDA-MB-231M2fnXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MW[yNFAh|ryPMUi0PEBpMkDmSG1UVw>?NVXa[lh1SW62aYT1cY9zKGGldHn2bZR6KGGpYXnud5QhcHWvYX6g[ZN1em:pZX6gdoVk\XC2b4Kg[IVncWOrZX70JG1FSS2PQj2yN|Eh[2WubIOge4l1cCCJSUWwJI9nKDBwMEGwPFYh|ryPMlzGNVk1OjhzNUW=
SNU1NFrDfoREgXSxdH;4bYMhSXO|YYm=M2LZOWlEPTB;NDFOwG0>MWKxPVU5PTl7OB?=
SK-N-SHMoruRZBweHSxc3nzJGF{e2G7NYfQT2ptPSEQvF2=Mm\VTY5lfWO2aX;uJI9nKGGyb4D0c5NqeyCjdDCwMlUhfG9iNTD1US=>MlnrNVk3OzF3NEm=
SK-N-SHNF7JN2RCeG:ydH;zbZMhSXO|YYm=NF3xNoY2KM7:TR?=MXrJcoR2[3Srb36gc4Yh[XCxcITvd4l{KGG|c3Xzd4VlKGG|IHPhd5Bie2ViMzDhZ5Rqfmm2eR?=M2nsNlE6PjNzNUS5
IMR90M2HIXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M1fvdlczKGh?MWrEUXNQMWXJR|UxRTFizszNNV7JUHhROTl4M{K4N|M>
L78NXLDbphIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NHfSRYY4OiCqM2XJbmROW09?M3i1dmlEPTB;Mj60JO69VQ>?NUTocopHOTl4M{K4N|M>
MOLT4MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M1X1elczKGh?MV7EUXNQMUnJR|UxRTBwMECyJO69VQ>?MnH2NVk3OzJ6M{O=
OS-RC2NX7WU5dYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M4K1[lczKGh?M3u4WWROW09?M3LmV2lEPTB;NT60JO69VQ>?NFfIfZkyQTZ|MkizNy=>
U251MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MlvEO|IhcA>?M4X2N2ROW09?NEXk[YlKSzVyPUCuOkDPxE1?MkPaNVk3OzJ6M{O=
HCT116Mo\5R5l1d3SxeHnjJGF{e2G7NHPOeVk4OiCqMn;OSG1UVw>?NXXpdJA6UUN3ME2wMlAxPiEQvF2=MV6xPVY2PTd4Mh?=
KBM4nsN2N6fG:2b4jpZ{BCe3OjeR?=NIPOVY84OiCqMoLMSG1UVw>?NX\1SoYxUUN3ME2wMlAxOSEQvF2=MYOxPVY2PTd4Mh?=
B16-BL6MUnDfZRwfG:6aXOgRZN{[Xl?NYLWTWpEPzJiaB?=M{\zNmROW09?M2nhcmlEPTB;Mz6wO{DPxE1?M1LaflE6Pjh7MUK1
Colon 26-L5M2DmbWN6fG:2b4jpZ{BCe3OjeR?=MknIO|IhcA>?MkP0SG1UVw>?MoPTTWM2OD1|LkGyJO69VQ>?NYrIZnh6OTl4OEmxNlU>
2008/MRP1NFXhdYtEgXSxdH;4bYMhSXO|YYm=MmTKOUBlNHW5eZJFVVORNFPKXFZKSzVyPUCuOVc4KM7:TR?=M4LY[FE6PzJ3NUe4
2008/PMmXxR5l1d3SxeHnjJGF{e2G7MVm1JIQ>M2\KO2ROW09?MUfJR|UxRTBwME[zJO69VQ>?Ml3kNVk4OjV3N{i=
HL60/MX2MXrDfZRwfG:6aXOgRZN{[Xl?NWHS[mJtPDhiaB?=NX7mXYt3TE2VTx?=MWrJR|UxRThwMES2JO69VQ>?NEXKSZcyQTd2M{i1PC=>
MDA-MB-453NVX1NVY1S3m2b4TvfIlkKEG|c3H5NHLNRWoxNjV6IN88[{9uVA>?NWHJeGs2PjliaB?=MmPMSG1UVw>?NVnBSmxxUUN3ME2wMlEzKM7:TR?=NYCzSppuOTl5OEiyPVA>
HCT15NHSzNG1EgXSxdH;4bYMhSXO|YYm=MmnHTWM2OD1yLkCzO{DPxE1?M2HF[|E6QDF7Nkm2
HuCCa1Mnr2R5l1d3SxeHnjJGF{e2G7Mk\pOEBlM1XUb2lEPTB;MD62OEDPxE1?NEm1SnIyQTh{NE[xPC=>
MOLT3MY\DfZRwfG:6aXOgRZN{[Xl?M{HhS2lEPTB;MD6wOEDPxE1?MVWxPVgzPDZzOB?=
IMR32NEDzfmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NUDCU21UPDhiaB?=Mk\hSG1UVw>?NHHIXZhKSzVyPUGuO{DPxE1?NWqySotLOTl7M{m1NlI>
MCF10ANHKxO5pEgXSxdH;4bYMhSXO|YYm=MY[0NEDPxE1?M2H2dVQ5KGh?MUfEUXNQNHnrcllKSzVyPUCuNVgh|ryPNX\WcVY6OjByNkS2O|Y>
MESSANXnMcmd1TnWwY4Tpc44hSXO|YYm=MX61NEDPxE1?MYSyJIg>NHLQfmJ4[XSnch?=MonaTY5lfWO2aX;uJI9nKESQQTDkZY1i\2ViYYPz[ZN{\WRiYYOgbY5kemWjc3WgbY4h[2:vZYSteIFqdCCuZX7neIg>NFr1[oszODF3MU[zPS=>
MESSAMnfoSpVv[3Srb36gRZN{[Xl?MX2yOUDPxE1?Ml\JNkBpNEDCcmt4[XSnch?=NGHTS4lE\WyudXzhdkB2eHSja3W=M4nsVlIxOTVzNkO5
MESSA/DX5NITRdnZHfW6ldHnvckBCe3OjeR?=MUG1NEDPxE1?MnjXNkBpM1rjW5difGW{M1XwNWlv\HWldHnvckBw\iCGTlGg[IFu[WenIHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKGOxbXX0MZRicWxibHXu[5RpMoX2NlAyPTF4M{m=
SKHepNUDiZpVNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NVvjb3pKPDhiaB?=MmDVSG1UVw>?NX3xZWtuUUN3ME2wMlA6KM7:TR?=MUCyNFE4OTFyOB?=
MIAPaCa2Mn7TR5l1d3SxeHnjJGF{e2G7NXTWVIdpOTByIN88US=>NFfhb5Y4OiCqMYnJR|UxRTBwMEGg{txONGH0fZUzODJyN{C0PS=>
SKHEP1MX3DfZRwfG:6aXOgRZN{[Xl?MnTQOFghcA>?MmL2TWM2OD1yLkCxJO69VQ>?NUXV[HJqOjB{MUCzOFY>
U87MGMVLDfZRwfG:6aXOgRZN{[Xl?MljaOFghcA>?NH\scVhKSzVyPUCuNFE5KM7:TR?=MWCyNFIyODN2Nh?=
SK-N-MCM362UmN6fG:2b4jpZ{BCe3OjeR?=MUG3NkBpNHfEN3NKSzVyPUCuNVIh|ryPMkXzNlA{ODN5Nki=
GOTOM4XTb2N6fG:2b4jpZ{BCe3OjeR?=Mly1O|IhcA>?MXXJR|UxRTBwMEC0O|Mh|ryPM3HiZ|IxOzV4NkW1
HL60NGjaSmJEgXSxdH;4bYMhSXO|YYm=MoTWO|IhcA>?MVHJR|UxRTBwMECxNVMh|ryPMVWyNFM2PjZ3NR?=
K562NYrpVpdzS3m2b4TvfIlkKEG|c3H5NGDodlg4OiCqMYPJR|UxRTBwMEC2NVIh|ryPMV2yNFM2PjZ3NR?=
NB-1MXPDfZRwfG:6aXOgRZN{[Xl?M1\mPVczKGh?M1;GVWlEPTB;MD6wNFUyPSEQvF2=MkD1NlA{PTZ4NUW=
U937NXLUfYx6S3m2b4TvfIlkKEG|c3H5MljtO|IhcA>?M3nENWlEPTB;MD6wNFQ1PSEQvF2=MVmyNFM2PjZ3NR?=
HBI10ANXXqNmExS3m2b4TvfIlkKEG|c3H5NInt[3JESzVyPECuN{DPxE1?MlzmNlA{PjNzNEC=
3T3NF;BUHJEgXSxdH;4bYMhSXO|YYm=NV7pVld7OTBizszNNGK1V4E1QCCqMXPJR|UxRTNwNzFOwG0>M4XkPVIxPDB3OES0
NCI/ADRNHG3XFZEgXSxdH;4bYMhSXO|YYm=MV[yOVAh|rypL33MNGLsU4I1QCCqNVLQU3lYT0l3ME21Mlk6KM7:TR?=NUXLd5J6OjB2MUOxPFg>
OVCAR-3NHLHUmZEgXSxdH;4bYMhSXO|YYm=NHnpS3gzPTBizsznM41NM2XmZ|Q5KGh?MkfHS2k2OD1yLkC3JO69VQ>?NVLOb|E2OjB2MUOxPFg>
PCO3MXvDfZRwfG:6aXOgRZN{[Xl?NUDPSIl5OjVyIN88[{9uVA>?NIDRNlI1QCCqNIixd4pIUTVyPUCuNVch|ryPMWGyNFQyOzF6OB?=
CEM/ADR5000MWDBdI9xfG:|aYOgRZN{[Xl?M33HXlEh|rypL33MM4DXfVI1KGh?NXrKPFVrUW6mdXP0bY9vKG:oIHHwc5B1d3Orcx?=MXKyNFUzPzlzNx?=
CEM/ADR5000MknvSpVv[3Srb36gRZN{[Xl?NHXBcFcyKM7:Zz;tUC=>NV7DNGFxPiCqMoDITY5kemWjc3WgbY4hWk:VIHflcoVz[XSrb36=Mn7NNlA2Ojd7MUe=
GXF251LMYjDfZRwfG:6aXOgRZN{[Xl?MnvDNVAh|ryPM{P2VFI1KGh?NVrxeVVrUUN3ME2wMlA2OiEQvF2=M1naTlIxPTR3M{O0
MAXF401NLNYXncpVnS3m2b4TvfIlkKEG|c3H5MnTNNVAh|ryPNX\XOJh[OjRiaB?=M1Lkd2lEPTB;MD6wOVIh|ryPMlfGNlA2PDV|M{S=
MEXF462NLMkHYR5l1d3SxeHnjJGF{e2G7MXixNEDPxE1?M3rBbVI1KGh?M13ydmlEPTB;MD6wOVIh|ryPMl:2NlA2PDV|M{S=
PAXF1657LNGTLc4xEgXSxdH;4bYMhSXO|YYm=NXnQO5FZOTBizszNMmrlNlQhcA>?MoHtTWM2OD1yLkC1NkDPxE1?MUmyNFU1PTN|NB?=
HAECNHj2b2xEgXSxdH;4bYMhSXO|YYm=M{fYRlExOCEQvF2=MnfrNlQhcA>?MlfRSG1UVw>?NYHLb|dQUUN3ME2xN{DPxE1?MVGyNFU1Pzd7Nx?=
CCRF-CEMM4nrZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NXrpZpRlPDhiaB?=NWThUohOT0l3ME2wMlAzKM7:TR?=M{TWTFIxPTdyMUS1
NUGC3MmnxR5l1d3SxeHnjJGF{e2G7MULHTVUxRTBwMkCyJO69VQ>?NI\JPXMzODV5OUi3Oi=>
HCT-15NECzVmZEgXSxdH;4bYMhSXO|YYm=NXK1XI1wUUN3ME2wMlA{QCEQvF2=MnzaNlA2QTR6NEi=
COLO205NI[xN4pEgXSxdH;4bYMhSXO|YYm=NIXxOHc1QCCqNXiyPFVZTE2VTx?=M3HSWWdKPTB;MD6xJO69VQ>?NGHWWnMzODZ5M{[yOy=>
Hep3BNHfXTpdEgXSxdH;4bYMhSXO|YYm=NF3jPFkyOSCmMXPJR|UxRTBwMUSg{txOMYiyNFcyQDR5NR?=
SKOV3NWnTTI1qS3m2b4TvfIlkKEG|c3H5M1jmc2lEPTB;MD6wNFEh|ryPMmXoNlA4OTl3MES=
DWDNGPxS2REgXSxdH;4bYMhSXO|YYm=NVrHd4lTPCEQvF2=MWCyOEBpNEPqUVZIUTVyPUCuNUDPxE1?MYWyNFc{OjhzNx?=
SiHaM1m1WGN6fG:2b4jpZ{BCe3OjeR?=MXm0JO69VQ>?Mkn2NlQhcA>?MkLnS2k2OD1yLkG3JO69VQ>?MmfTNlA4OzJ6MUe=
THP1NVLVN5lzS3m2b4TvfIlkKEG|c3H5M1r4PVczKGh?NYjRNVk3TE2VTx?=NXO4[GM1UUN3ME2wMlAxQCEQvF2=NEexXm0zODh|M{C1Oy=>
ARPE19M1[xTWN6fG:2b4jpZ{BCe3OjeR?=M3HUVlQ5KGh?NXHzOWVCTE2VTx?=NVfPe2I4UUN3ME2wMlc3KM7:TR?=MWiyNFk{OTl5MB?=
BJMlm2R5l1d3SxeHnjJGF{e2G7NUP3OnpkPDhiaB?=NYfKNYFFTE2VTx?=NIH5XnJKSzVyPUKuN|Mh|ryPM3\KflIxQTNzOUew
KB8.5MmnZR5l1d3SxeHnjJGF{e2G7NYm5bIJHPTBizszNNXvRW5lzPzJiaB?=NVq4NXBkTE2VTx?=MoizTWM2OD1|LkOg{txONFjjbmMzOTB|NUKzOC=>
H460M4C2OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MnHnO|IhcA>?M37MSGlEPTB;MD6wNFA{QCEQvF2=NWfXN|Z5OjFyNke5N|A>
KBMlfKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NGHxTG84OiCqNGDw[3ZKSzVyPUCuNFAxOjNizszNM4SxVlIyODZ5OUOw
MKN45NXPT[GE3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NFP0emQ4OiCqMlXFTWM2OD1yLkCwNFE6KM7:TR?=MnXZNlExPjd7M{C=
C33AMV;DfZRwfG:6aXOgRZN{[Xl?MUexNFAh|rypL33MMmTXOFghcA>?NHX3RopKSzVyPUCuPFIh|ryPNYTTXnBEOjFyN{GyNlE>
HL60RMonnR5l1d3SxeHnjJGF{e2G7NYXXbmtGOTBizszNMmq4O|IhcA>?MWHEUXNQMkTtTWM2OD1yLkm5JO69VQ>?MlHBNlEyPDJzOEC=
MDA231NGPnWWdEgXSxdH;4bYMhSXO|YYm=NFric2YyOCEQvF2=MX23NkBpM1jkU2ROW09?NHnnU21KSzVyPUSuO5gyOC13IN88US=>M{HCSlIyOTR{MUiw
MDA435MY\DfZRwfG:6aXOgRZN{[Xl?MnLMNVAh|ryPMl7sO|IhcA>?M3;6TGROW09?MkG2TWM2OD1yLkCwN|Uh|ryPM{Xh[lIyOTR{MUiw
CEMMmXwR5l1d3SxeHnjJGF{e2G7NX3lTIo6PzJiaB?=MorJSG1UVw>?M2TvPWlEPTB;MD6wOkDPxE1?NGqzfoYzOTF2NE[yOC=>
Molt4/C8MlfRR5l1d3SxeHnjJGF{e2G7MlntO|IhcA>?MXnEUXNQNH\CO2xKSzVyPUCuNkDPxE1?NEPJ[WYzOTF2NE[yOC=>
IMR90MXzDfZRwfG:6aXOgRZN{[Xl?MVy0PEBpMV\EUXNQM1KwPGlEPTB;MD61PUDPxE1?MkLxNlEzOTV4MkO=
CCRFNHjuW3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M1nqWVk3KGh?NVTr[2pbTE2VTx?=MV\JR|UxRTBwMEO3OUDPxE1?MWSyNVI6PjR4Nx?=
HepG2NHfjOnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=Ml\YPVYhcA>?M2HMNGROW09?NHXF[GhKSzVyPUCuNFE6KM7:TR?=NUfMZZNNOjF{OU[0Olc>
HUVECMknNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NV\0eHlwQTZiaB?=MlHLSG1UVw>?NWLjSo5OUUN3ME2wMlA{ODNizszNNEjDfVMzOTJ7NkS2Oy=>
NCI-N87MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NVq3NJBjQTZiaB?=M4PFV2ROW09?M3HWb2lEPTB;MD60NVk5KM7:TR?=NGnTXIczOTJ7NkS2Oy=>
HCT8NIPj[VBEgXSxdH;4bYMhSXO|YYm=NXLxNIRwOC53ODFOwIcwdUx?Mn\QOlkhcA>?MnjySG1UVw>?MnmyTWM2OD1yLkCyJO69VQ>?NX:yNFBSOjF|OEG3NFU>
A375NEXLOWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M1mxRVczKGh?M1nRSnBDWw>?MlPzTWM2OD1yLkGzJO69VQ>?NIPJ[|EzOTR7Nkm3Ni=>
SF295MlTwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NWr0N5g{OjVibl2=M1q3XlI1KGh?MkC3SG1UVw>?NE\3cJpKSzVyPUSuOEDPxE1?NYfH[nM1OjF3NUO4Nlk>
SK-MEL-28NIPvbZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M3zic|I2KG6PNU\zbFM{OjRiaB?=NUK1SYR7TE2VTx?=M2XjVWlEPTB;MD62JO69VQ>?NWXybFROOjF3NUO4Nlk>
KATOIIIMWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M3z0OGlEPTB;ND6zPEDPxE1?MVyyNVU4ODd3MB?=
P388D1NInYR5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M13nU2lEPTB;MD6zN|gh|ryPMmfTNlE2PzB5NUC=
H22NIfQ[lRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=Mn7aOFghcA>?MYDJR|UxRTN4LkWxJO69VQ>?MY[yNVYzODV{OR?=
S180NEfXfYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M{HBW|Q5KGh?MUHJR|UxRTJ7LkKg{txONXrHR2xxOjF4MkC1Nlk>
SW480NEjZSFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M1GzZVQ5KGh?MY\JR|UxRTBwME[g{txOMnjSNlE3PDF4OUS=
HOP62MVjDfZRwfG:6aXOgRZN{[Xl?NXfmN41XOjRiaB?=NYT5OYU2T0l3ME2wMlE1KM7:TR?=NY\McnFCOjF4N{[1NFY>
BT549MoD6R5l1d3SxeHnjJGF{e2G7MXOxOlAh|rypL33MNUDOTFduPSCmNF\3[Y9FVVORM{TNXWdKPTB;MD6wNUDPxE1?MlnDNlE4OTFyNUS=
Hs578NUnybmdZS3m2b4TvfIlkKEG|c3H5MXixOlAh|rypL33MM2fmSlUh\A>?MmflSG1UVw>?NUDRTYQzT0l3ME2wMlAxPiEQvF2=M4Wxb|IyPzFzMEW0
NCI-H23NHnw[XVEgXSxdH;4bYMhSXO|YYm=MWexOlAh|rypL33MMXS1JIQ>NXX5c4c5TE2VTx?=M4DweWdKPTB;MD6wNFUh|ryPMkT1NlE4OTFyNUS=
PC3NW[zR|dMS3m2b4TvfIlkKEG|c3H5NVv4XoNXOTZyIN88[{9uVA>?MWW1JIQ>M4jVbmROW09?NHHh[pVIUTVyPUCuNFIyKM7:TR?=M{T0XVIyPzFzMEW0
MG63NXnOVHEyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MX:3NkBpM{nZcWlEPTB;Mj64JO69VQ>?M3HNflIyPzJzNUG5
Ew36MmeyR5l1d3SxeHnjJGF{e2G7Mn\oO|IhcA>?M4Hu[2lEPTB;MD6wNUDPxE1?M4HaPVIyPzJzNUK4
HEK293M1Xyc2N6fG:2b4jpZ{BCe3OjeR?=M3z3flczKGh?NGTTboJKSzVyPUCuNFEh|ryPNV[2XYZEOjF5MkG1Nlg>
HEK293M3vzUmN6fG:2b4jpZ{BCe3OjeR?=MofDO|IhcA>?M1zIbWlEPTB;MD60NkDPxE1?MnnkNlE4OjF3Mki=
KB3-1Mn3tR5l1d3SxeHnjJGF{e2G7Mmi4O|IhcA>?MYHJR|UxRTBwMEKg{txONUXlToNQOjF5MkG1Nlg>
KBV1NWfjb491S3m2b4TvfIlkKEG|c3H5Mn;2O|IhcA>?NIHRS3VKSzVyPUSuO{DPxE1?NInpbVUzOTd{MUWyPC=>
LLC-PK1NWDYNnByS3m2b4TvfIlkKEG|c3H5M{PjNVczKGh?Mn61TWM2OD1yLkKg{txOM3X0e|IyPzJzNUK4
NCI/ADR-RESNF\0UY9EgXSxdH;4bYMhSXO|YYm=MlT0O|IhcA>?M3nrdWlEPTB;OT6zJO69VQ>?NFr3fWYzOTd{MUWyPC=>
NIH3T3NWC2d5lsS3m2b4TvfIlkKEG|c3H5M1fQ[lczKGh?MV7JR|UxRTBwMEWg{txOMn7FNlE4OjF3Mki=
SW620Mn7qR5l1d3SxeHnjJGF{e2G7MmrOO|IhcA>?NG\BNnBKSzVyPUCuNFEh|ryPNIfkXpkzOTd{MUWyPC=>
ZR-75BMYXDfZRwfG:6aXOgRZN{[Xl?MkGxO|IhcA>?Mk\BTWM2OD1yLkC0JO69VQ>?MYSyNVczOTV{OB?=
ZR-75BNYmy[m5GS3m2b4TvfIlkKEG|c3H5M3TxdVczKGh?MXTJR|UxRTJwMEKg{txONYrqR2Z7OjF5MkG1Nlg>
GuravNGrhN2hEgXSxdH;4bYMhSXO|YYm=MWexNFAh|ryPMYi0PEBpM1yy[GROW09?NWrYS4pTT0l3MEywMlEh|ryPMVKyNVc{PzJ6OB?=
HFFMonwR5l1d3SxeHnjJGF{e2G7MXO3NkBpNGP2eI5ESzVyPUCuNFMh|ryPMWeyNVc1OTF|MR?=
BT474MVvDfZRwfG:6aXOgRZN{[Xl?M1fnU|czKGh?M{j4eGlEPTB;MD6wO{DPxE1?MWGyNVc1OTh|Mx?=
ChaGoNX;0cI9vS3m2b4TvfIlkKEG|c3H5MnKzO|IhcA>?NHXNTI5KSzVyPUCuPFMh|ryPNFzlZZkzOTd2MUizNy=>
KATOMVXDfZRwfG:6aXOgRZN{[Xl?M2DFVVczKGh?MkLQTWM2OD1yLkOzJO69VQ>?MlrrNlE4PDF6M{O=
NCI-H187NXjmeZpnS3m2b4TvfIlkKEG|c3H5MVm3NkBpMoTBTWM2OD1yLkCzJO69VQ>?M4W5SVIyPzRzOEOz
A2780NWPKbXpyS3m2b4TvfIlkKEG|c3H5NH\6[4tKSzVyPUCuNFAyOiEQvF2=NV;S[YNPOjF5N{S0PVk>
A2780/ADRMnjvR5l1d3SxeHnjJGF{e2G7NYKxN|FIUUN3ME2wMlE6PCEQvF2=NUT2bphWOjF5N{S0PVk>
LAMA-84NFHLVnREgXSxdH;4bYMhSXO|YYm=NHPQNlY1QCCqNVyxVWdJUUN3ME2wMlc1KM7:TR?=NXXlcmp7OjF5OUeyPFA>
SH-SY5YNGL2elBEgXSxdH;4bYMhSXO|YYm=MXu0PEBpMV7JR|UxRTBwNTFOwG0>MXyyNVc6PzJ6MB?=
Ca9-22Mn3QR5l1d3SxeHnjJGF{e2G7NEHWPYM4OiCqNEjyPGpFVVORMmXOTWM2OD1yLkK2JO69VQ>?NFvGd4YzOThyMEi1PS=>
K562/A02NF\PPZpEgXSxdH;4bYMhSXO|YYm=MkfnOFghcA>?MY\EUXNQMn3OTWM2OD1zNz64OEDPxE1?MnrDNlE5PDN7NEC=
BT20NH34WXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M2LHW|ExKM7:TR?=MmOxO|IhcA>?NITHNXpCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fS=>MmriNlE5PTJyMkO=
AGSMo\aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M2LBWFQ5KGh?MmjxS2k2OD1yLkCxJO69VQ>?M4LpXlIyQDd3MES2
PC3NVrrV3pOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M3PSO|Q5KGh?MYXHTVUxRTBwMEmg{txONYToVWR4OjF6N{WwOFY>
Neuro2aMWXDfZRwfG:6aXOgRZN{[Xl?Ml3aO|IhcA>?NGfkNY1KSzVyPUGuNkDPxE1?MXmyNVk6PjVzOR?=
MCF7MYfGeY5kfGmxbjDBd5NigQ>?MVq1NEDPxGdxbVy=Ml\wOFghcA>?NFjVdWtFVVORNUfkRXVnWmWmdXP0bY9vKGmwIG\FS2YhdVKQQTDlfJBz\XO|aX;uMoPsNlIxODB7NE[=
MCF7NWq5[ohsTnWwY4Tpc44hSXO|YYm=MVe1NEDPxGdxbVy=NFLteXA1QCCqMnv5SG1UVw>?NYLDWWd1WmWmdXP0bY9vKGmwIFPZVFE6KG2UTlGg[ZhxemW|c3nvci=>NX;rcmVvOjJyMEC5OFY>
MCF7NVv0WnpPTnWwY4Tpc44hSXO|YYm=NH\FOWc2OCEQvHevcWw>MljZOFghcA>?MVPEUXNQMoHNVoVlfWO2aX;uJIlvKEGSLUKg[4FudWFibWLORUBmgHC{ZYPzbY9vNXjJTI92OjJyMEC5OFY>
HCT8M{joTmN6fG:2b4jpZ{BCe3OjeR?=MWS1xsDPxGdxbVy=NVe0S5dsPzJiaB?=MVPEUXNQMV\JR|UxRTBwMEKg{txONY\FfmlwOjJyMEC5OFk>
BGC823MkS3R5l1d3SxeHnjJGF{e2G7MV25OkBpM2jrcGROW09?MYDJR|UxRTBwOUig{txONIf2OokzOjB5ME[1OC=>
SKOV3MnPzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M{LoUlUxKM7:TR?=MXu3NkBpNWHIUY9pTE2VTx?=M{HQPWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iU1vPWlMh[2WubIOgc5ZmemW6cILld5NqdmdiYz3TdoM>MVuyNlEyQTR5Mh?=
RAW264.7MkTQR5l1d3SxeHnjJGF{e2G7MUCxNEDPxE1?MkjtNlQhcA>?M3LabWROW09?M3y2[2N6fG:2b4jpZ4l1gSCjc4Pld5Nm\CCjczDj[YxtKH[rYXLpcIl1gQ>?MUWyNlEzQTB4MR?=
A375-C5NEHITHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M2HmPVQ5KGh?NFu0Z|lFVVORM1;XOmdKPTB;MD6wPVE2KM7:TR?=NGH4N5kzOjF5N{SwPS=>
QGY7701MUDDfZRwfG:6aXOgRZN{[Xl?NF64UYEzPCCqNYftVGNiTE2VTx?=NXSwXVFzUUN3ME24MlY2KM7:TR?=NYPtXYRmOjJzOEK5NlY>
PC3MNWe1[XhWS3m2b4TvfIlkKEG|c3H5NV7OdllOPzJiaB?=NH:3cGpFVVORM1;4fGlEPTB;MD6yOEDPxE1?NXXSSHNQOjJ{NkSxOFk>
LNcaPM2DQNmFxd3C2b4Ppd{BCe3OjeR?=M{K4Z|IxyqEQvHevcWw>MVqyOEBpM4rjdZdifGW{MWrJcoR2[3Srb36gc4Yh[XCxcITvd4l{KGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJINie3Cjc3WgN{84KGGldHn2ZZRqd25?MWGyNlI3PDd3OB?=
SKOV3MWTGeY5kfGmxbjDBd5NigQ>?NYjWWXZWPSEQvF2=NX\jU49ROSCqNHy3OpdFVVORNUWzNGdzTHK3ZzD1dJRic2ViaX6g[I95d3K3YnnjbY4uemW|aYP0ZY51KGi3bXHuJHNMV1Z|IHPlcIwhdnWlbHX1NYHOZmFJOjJ{N{[5PVg>
SKOV3M1zLW2Z2dmO2aX;uJGF{e2G7NXvFRpZDPSEQvF2=MXWxJIg>M4D6SGROW09?M2PEPWNmdGy3bHHyJJVxfGGtZTDpckBld3ixcoXibYNqdi2{ZYPpd5RidnRiaIXtZY4hW0uRVkOgZ4VtdHN?MmPRNlIzPzZ7OUi=
B16MUfDfZRwfG:6aXOgRZN{[Xl?NVn6fXh3PzJiaB?=NH\kS2tFVVORMmrrTWM2OD1yLkGg{txOMVqyNlM{ODZ|NB?=
SiHaM2XFcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MlrhS2k2OD1yLkG0JO69VQ>?NXGyV282OjJ|NkG2PFQ>
SK-N-SHMYDDfZRwfG:6aXOgRZN{[Xl?NVi1d21UPDhiaB?=M3Xjc2lEPTB;MD65O{DPxE1?MVWyNlM5PjV{OB?=
HuH7MUjGeY5kfGmxbjDBd5NigQ>?Moq2NlUhdmdxbVy=Ml7OO|IhcA>?MkftSG1UVw>?NXjWOWxFUW6mdXP0bY9vKG:oIIPlcoV{[2WwY3WgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5ic3Xu[ZNk\W6lZTDhd5Nw[2mjdHXkJIJmfGFvZ3HsZYN1d3OrZHHz[UBi[3Srdnn0fS=>M1K3VFIzPDB7N{ex
HuH7NHzDdplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NFjZSoszPSCwZz;tUC=>NH72NXk4OiCqMkDqSG1UVw>?NVHHVVdTSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBDemSXIHnuZ49zeG:{YYTpc44>Mn7CNlI1ODl5N{G=
K562/A02MlT0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NXPiZ5cxPzJiaB?=MVzEUXNQM4P2eWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgcZVtfGmmcoXnMZJme2m|dHHueEBpfW2jbjDLOVYzN0FyMjDj[YxteyCxdnXy[ZhxemW|c3nu[{BxNWeueXPvdJJwfGWrbjD3bZRpKEmFNUCgc4YhPDZwNkmg{txONG[2XmczOjR3MEGzOC=>
SK-MEL-2NF23TXFEgXSxdH;4bYMhSXO|YYm=MXi0PEBpMoO1TWM2OD1yLkCwNkDPxE1?NEn4clEzOjR6M{O5OS=>
XF498M{\jNGN6fG:2b4jpZ{BCe3OjeR?=NEPkNGg1QCCqNWfnWpZMUUN3ME2wMlAyPSEQvF2=NUnpb3JwOjJ2OEOzPVU>
LLCNF3YWoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NGDQR2k1QCCqM{jhd2lEPTB;MD6yNFch|ryPNV\iWGk{OjJ3MUWzOlY>
NCI-H290MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NH\K[lIzKM7:TR?=NE\ZXoc1QCCqMVLJR|UxRTBwM{Kg{txOMnzBNlI2OTV|Nk[=
U87MGM1HNVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M{HDcVIh|ryPM3LieVQ5KGh?NGPhXIFKSzVyPUCuO|kh|ryPM17jTlIzPTF3M{[2
KB/VCRM3jZ[mN6fG:2b4jpZ{BCe3OjeR?=M3XURVUxOCEQvF2=MYm0PEBpMWDEUXNQMoT2TWM2OD1yLkS1JO69VQ>?NVqzdJlKOjJ3M{ezOlI>
SMMC7721MUfDfZRwfG:6aXOgRZN{[Xl?M4fUUFUxOCEQvF2=NX\mZnM4PDhiaB?=M3TlfGROW09?MWnJR|UxRTBwM{eg{txONXP3VJJCOjJ3M{ezOlI>
786-0NWftUGc4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NYrPS5hKOjVizsznM41NMYq0PEBpM4TYNWlEPTB;Mj6xJO69VQ>?NXnpPZlbOjJ3M{e2PFA>
NCI/ADRMWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MVGyOUDPxGdxbVy=MmewOFghcA>?M3q3XGlEPTB;MUOuOUDPxE1?Mn[zNlI2Ozd4OEC=
SW620MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MU[xNFAh|ryPMVu3NkBpM3P0XGROW09?MnTFTWM2OD1yLkC0JO69VQ>?MlvoNlI2PTVzNUK=
WI38MlzvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MUixNFAh|ryPMWK3NkBpMUTEUXNQNUXST2xrUUN3ME2wMlA1KM7:TR?=NHi5fFEzOjV3NUG1Ni=>
J774A.1M{fmdWN6fG:2b4jpZ{BCe3OjeR?=NF\HfFY4OiCqNV\FSlZlTE2VTx?=Mn;OTWM2OD1yLkCyJO69VQ>?NYOyelFDOjJ4MEi2O|U>
BMDMMWPDfZRwfG:6aXOgRZN{[Xl?MnS4NlUxKM7:Zz;tUC=>NHKwe5g4OiCqM4H0XWlEPTB;ND62JO69VQ>?NGDOO3UzOjZzNkW1OC=>
HMEC1MV3DfZRwfG:6aXOgRZN{[Xl?MWmyOVAh|rypL33MMX63NkBpM4HUR2lEPTB;MD6wOkDPxE1?NH;jdIgzOjZzNkW1OC=>
MKN45NHzVNGREgXSxdH;4bYMhSXO|YYm=M2jNXVQ5KGh?MUTEUXNQNYez[mEyUUN3ME2wMlE3QCEQvF2=M1zvSlIzPjR5N{Kz
B16M{nOZ|Q5KGh?MXPJR|UxRTBwMEOg{txOM1P6dlIzPjZ6NEWx
U2OSMUTDfZRwfG:6aXOgRZN{[Xl?NWTpOolbPCEQvF2=NHS2OZQ4OiCqMWHEUXNQNEnzdXFKSzVyPUOuOEDPxE1?NXXUXIJnOjJ5NEmyO|k>
HCT15MV3DfZRwfG:6aXOgRZN{[Xl?Moj1OFghcA>?MVLEUXNQMn:zTWM2OD1yLkCwOUDPxE1?MUSyNlg2QDJ7OB?=
SKLU1NXm5cZRXS3m2b4TvfIlkKEG|c3H5NV\qUmhnPDhiaB?=MUDEUXNQNHrEV2tKSzVyPUCuNFA3PyEQvF2=M{TrfFIzQDV6Mkm4
MESSA/DX5NYDhOoRTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MnrhNVAxKM7:Zz;tUC=>NYPpe2tQPzJiaB?=M1\ESmROW09?M1vIWGlEPTB;MD6yOUDPxE1?MXGyNlk1PDF{MR?=
A549NIjv[ZREgXSxdH;4bYMhSXO|YYm=MYTJR|UxRTBwMECxJO69VQ>?M{LqTFIzQTVzMESw
HL60/AM1PHXmN6fG:2b4jpZ{BCe3OjeR?=M2PPblE5KGh?Moe1TWM2OD14Lkeg{txOMVOyNlk5PTB{Nx?=
MG63NYTiSnVWS3m2b4TvfIlkKEG|c3H5M{H4TmlEPTB;Mj63JO69VQ>?MnXvNlMxPDN2OUi=
BALB/3T3MX;DfZRwfG:6aXOgRZN{[Xl?MmTPNVAxKM7:Zz;tUC=>MWe3NkBpNWDMSm8yTE2VTx?=MmPlTWM2OD1zLkmxJO69VQ>?MXyyN|A4QTV{Mx?=
HL60/VincM{W0dWN6fG:2b4jpZ{BCe3OjeR?=M4DtRlExOCEQvHevcWw>MU[3NkBpMojOSG1UVw>?NEPmbpJEgXSxdH;4bYNqfHliYXfhbY5{fCC4aX7jdol{fGmwZT3y[ZNqe3SjboSgbJVu[W5iSFy2NE9XcW6lIHPlcIx{KHerdHigTWM2OCCxZjCwMlkyKM7:TR?=NV3CR4lmOjNyN{m1NlM>
Bcap37NULxdnZYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MYWyNEDPxE1?NHj6cIs4OiCqMUPEUXNQMXvJR|UxRTFwMkig{txONX3xe|Z6OjNzMkSyNVA>
MGC803MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NVizfpF[OjBizszNMVe3NkBpNFvUWHJFVVORM4LOOWlEPTB;MD63JO69VQ>?M3XXVVI{OTJ2MkGw
MOLT4M{PNTmN6fG:2b4jpZ{BCe3OjeR?=M{O4b|Q5KGh?MXvEUXNQMonQTWM2OD1yLkCyJO69VQ>?NE\YVo4zOzJzOEexPC=>
WHCO1NUHhRYFFS3m2b4TvfIlkKEG|c3H5MXO0PEBpMmrqSG1UVw>?NGTpdWVKSzVyPUCuOUDPxE1?M{L4PVI{OzV|N{S3
AT6-1MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M{LKUVczKGh?NY\HbotZUUN3ME2yJO69VQ>?NHf6OYEzOzN4MEWyNS=>
L929NVvmPFVrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MlnNO|IhcA>?MmTQTWM2OD1yLkG2NUDPxE1?NEHyZ44zOzN4MEWyNS=>
OSRGANFfKVJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NG\6S|Q4OiCqMkjSTWM2OD1yLkC5N{DPxE1?NF\1b5UzOzN4MEWyNS=>
POS1M2rkW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7M2H6ZVczKGh?M1zoXmlEPTB;MD6wOFMh|ryPMkjPNlM{PjB3MkG=
HeLaM{nxV2N6fG:2b4jpZ{BCe3OjeR?=M4TDd|Eh|ryPM37hUlczKGh?NUHCN5JtUUN3ME2wMlAyKM7:TR?=MXSyN|Q4ODF|OR?=
SK-MELNVPYcVZOS3m2b4TvfIlkKEG|c3H5M1XicFQ5KGh?NHjiZ2FFVVORMn3QTWM2OD1zLkWg{txOMVOyN|U1Pzh2Mx?=
MA9.3M1TiWGN6fG:2b4jpZ{BCe3OjeR?=NYfLVpoxOTByIN88US=>MWe0PEBpNEjGVG1KSzVyPUCuNFg3KM7:TR?=M3PxZVI{PTd6Nkmw
A673Mnj6R5l1d3SxeHnjJGF{e2G7M2PFc|czKGh?MW\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBOlc{KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDy[ZNignW{aX6vdoV{d3K3ZnnuMYJie2WmIH\seY9z\XOlZX7j[UBie3OjeTD3bZRpKEmFNUCgc4YhOC5zNzFOwG0>NYfQSJVEOjN4MEC5NlU>
A673NE\5TFRCeG:ydH;zbZMhSXO|YYm=M3i3OVI1KGh?MlmxSG1UVw>?NIDJcpFKdmS3Y4Tpc44hd2ZiYYDvdJRwe2m|IHHzd4V{e2WmIHHzJINie3Cjc3WtN{Bi[3SrdnH0bY9vKHerdHigSWM2OCCxZjCwMlM6KM7:TR?=NXvRTVl4OjN4MEC5NlU>
MDA-MB-436NI[1PZVEgXSxdH;4bYMhSXO|YYm=MoHlO|IhcA>?NEnEemxKSzVyPUCuNUDPxE1?MVGyN|YxODl{NR?=
MNNG-HOSM2LhZ2N6fG:2b4jpZ{BCe3OjeR?=NXuyXGRXPzJiaB?=NH:yfZhKSzVyPUCuOVkh|ryPMX[yN|YxODl{NR?=
NCI-H929M{XET2N6fG:2b4jpZ{BCe3OjeR?=M4j0[lczKGh?NYP0VZA1UUN3ME2wMlA3PSEQvF2=NG\N[HIzOzZyMEmyOS=>
SK-BR-3M1;iPGN6fG:2b4jpZ{BCe3OjeR?=NHvrPZI4OiCqMn65TWM2OD1yLkC5JO69VQ>?MnL6NlM3ODB7MkW=
SK-ES-1MYLDfZRwfG:6aXOgRZN{[Xl?NV;JcYQ4PzJiaB?=NXXEeWdrUUN3ME2wMlA1OiEQvF2=NGTVO2kzOzZyMEmyOS=>
SK-UT-1MUPDfZRwfG:6aXOgRZN{[Xl?MYC3NkBpMVTJR|UxRTBwMEe2JO69VQ>?NG\rR3EzOzZyMEmyOS=>
SW872NIL0SlJEgXSxdH;4bYMhSXO|YYm=MlO0O|IhcA>?NWPvfHp3UUN3ME2wMlE1KM7:TR?=M3ntbFI{PjByOUK1
U266M3ewV2N6fG:2b4jpZ{BCe3OjeR?=Mm\2O|IhcA>?M33iWWlEPTB;MD62O{DPxE1?MYGyN|YxODl{NR?=
JURKAT-TALLMmfYR5l1d3SxeHnjJGF{e2G7NYPTe49PPDhiaB?=NWHXTWk6UUN3ME2wMlAxQTZizszNMXSyN|Y4OzJzOB?=
B16F10MkXoR5l1d3SxeHnjJGF{e2G7NFPIR2U1QCCqNH3TRpBFVVORM{f3RWlEPTB;MD6wO|Ih|ryPMm[3NlM4Pzd6OUi=
C643M{i2fGN6fG:2b4jpZ{BCe3OjeR?=NFzSTFUzPSCvTR?=MYGyOEBpMWPJR|UxRTBwMEeg{txOMYiyN|gxOjdzNh?=
HGFMYTDfZRwfG:6aXOgRZN{[Xl?MknMNlUhdU1?MlPCNlQhcA>?NXjBTHFNUUN3ME2wMlUh|ryPM2DoV|I{QDB{N{G2
786M{DvZWN6fG:2b4jpZ{BCe3OjeR?=NF3DTWI1QCCqMm\GSG1UVw>?NFzDbJNKSzVyPUCuN|Mh|ryPMlOwNlM5OTB{OEK=
LS180MVTDfZRwfG:6aXOgRZN{[Xl?M1rxflczKGh?M4i2bmROW09?MVjJR|UxRTBwMESg{txOMlzLNlM5OjdzN{m=
COLO205MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M3fPXVExOCEQvF2=Ml7MOFghcA>?NXvmcXR1T0l3ME2wMlE1KM7:TR?=NHLjRnozOzh2OUKwOy=>
DWDNGe2UmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NHqxPIkyODBizszNMkm2OFghcA>?M{fDNmdKPTB;MD6xJO69VQ>?NIG4[5EzOzh2OUKwOy=>
GuravM{DzNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NInxS5IyODBizszNM17URlQ5KGh?M3X4OWdKPTB;MD6xO{DPxE1?NW\1TnI5OjN6NEmyNFc>
HOP62MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NWXUd45OOTByIN88US=>MVS0PEBpMYfHTVUxRTBwMUSg{txONWPvdJd5OjN6NEmyNFc>
786-0MW\DfZRwfG:6aXOgRZN{[Xl?NXnhTmxlOTByIN88US=>MXG0PEBpNUDkc3FFT0l3ME2wMlE{KM7:TR?=MX[yN|g4OTlyNR?=
ACHNM1fadWN6fG:2b4jpZ{BCe3OjeR?=MmDGNVAxKM7:TR?=M4j0XlQ5KGh?MXXHTVUxRTBwMEig{txONWHXNoFlOjN6N{G5NFU>
Caki1NEjCVGREgXSxdH;4bYMhSXO|YYm=Mn7aNVAxKM7:TR?=M1r0clQ5KGh?M1nlfGdKPTB;MD65OUDPxE1?NELxUHQzOzh5MUmwOS=>
EKVXMUjDfZRwfG:6aXOgRZN{[Xl?M1jhTFExOCEQvF2=MXy0PEBpNGjNUWlIUTVyPUCuOFEh|ryPM3\1WVI{QDdzOUC1
HCC2998M1;KdmN6fG:2b4jpZ{BCe3OjeR?=NH;Xem8yODBizszNNIDQVnY1QCCqNFfTR4JIUTVyPUCuNlYh|ryPMm\qNlM5PzF7MEW=
HOP92M1j0SGN6fG:2b4jpZ{BCe3OjeR?=MkTWNVAxKM7:TR?=M3XsOlQ5KGh?NGPVUFZIUTVyPUCuNUDPxE1?MnnzNlM5PzF7MEW=
IGROVINXvW[oIxS3m2b4TvfIlkKEG|c3H5MV6xNFAh|ryPMWO0PEBpNWnrbmF6T0l3ME2wMlE4KM7:TR?=NGCzcGczOzh5MUmwOS=>
KM12MlyxR5l1d3SxeHnjJGF{e2G7M3rRcFExOCEQvF2=NHzBR5g1QCCqMUjHTVUxRTBwMkeg{txONV\2SIJnOjN6N{G5NFU>
LOXIMVIMnLBR5l1d3SxeHnjJGF{e2G7NWmwNIVLOTByIN88US=>NXLXfVM6PDhiaB?=M3zjPGdKPTB;MD6wO{DPxE1?NH[ySJczOzh5MUmwOS=>
M14M{jEZ2N6fG:2b4jpZ{BCe3OjeR?=M3jRblExOCEQvF2=NGLWXXE1QCCqM1PxU2dKPTB;MD6xPEDPxE1?MnfqNlM5PzF7MEW=
MALME-3MNI\qeJFEgXSxdH;4bYMhSXO|YYm=MlHwNVAxKM7:TR?=NHzLS2k1QCCqNVXtUJRqT0l3ME2wMlEzKM7:TR?=MVWyN|g4OTlyNR?=
NCI-H226Mo\zR5l1d3SxeHnjJGF{e2G7NIPXTpAyODBizszNNYfrOGloPDhiaB?=M17PdWdKPTB;MD6wOUDPxE1?NW[0NpJlOjN6N{G5NFU>
NCI-H322MMXjDfZRwfG:6aXOgRZN{[Xl?M3u4PVExOCEQvF2=NUXxSWxXPDhiaB?=MVrHTVUxRTBwNUSg{txONXnBZXkyOjN6N{G5NFU>
NCI-H522M{fPeGN6fG:2b4jpZ{BCe3OjeR?=NEXrRlAyODBizszNMWO0PEBpM4fQXmdKPTB;MD6wN{DPxE1?NImzOVMzOzh5MUmwOS=>
OVCAR4NIGyd5hEgXSxdH;4bYMhSXO|YYm=MlPLNVAxKM7:TR?=MVW0PEBpMkDCS2k2OD1yLkO3JO69VQ>?NYixWHRpOjN6N{G5NFU>
OVCAR5NIfydYpEgXSxdH;4bYMhSXO|YYm=NGfR[pEyODBizszNNVLxfplzPDhiaB?=M3\1eGdKPTB;MD60NUDPxE1?M4P1XlI{QDdzOUC1
OVCAR-8NF[y[pREgXSxdH;4bYMhSXO|YYm=NV7HOnI4OTByIN88US=>M1;OSFQ5KGh?NUPQc2lmT0l3ME2wMlEh|ryPNFzxcVkzOzh5MUmwOS=>
PRMI8226M2r6XGN6fG:2b4jpZ{BCe3OjeR?=MVixNFAh|ryPNFzZdmc1QCCqMlvmS2k2OD1yLkC4JO69VQ>?MoHGNlM5PzF7MEW=
RXF393NYLXXoc4S3m2b4TvfIlkKEG|c3H5NVnCXGRGOTByIN88US=>NH;BPVE1QCCqM2LK[mdKPTB;MD6xJO69VQ>?NHXoNoszOzh5MUmwOS=>
SF539NWmweVJDS3m2b4TvfIlkKEG|c3H5NEfBelUyODBizszNMVe0PEBpM{fRSGdKPTB;MD6xNkDPxE1?MWKyN|g4OTlyNR?=
SK-MEL-28M1jSZ2N6fG:2b4jpZ{BCe3OjeR?=MknVNVAxKM7:TR?=NF;LRWs1QCCqMnzaS2k2OD1yLkKxJO69VQ>?M1nHNFI{QDdzOUC1
SN12CNFrKNW5EgXSxdH;4bYMhSXO|YYm=M1HpUlExOCEQvF2=MlP2OFghcA>?NH;rZnhIUTVyPUCuNFch|ryPM4ezS|I{QDdzOUC1
SNB19M3;1WWN6fG:2b4jpZ{BCe3OjeR?=Ml31NVAxKM7:TR?=MYi0PEBpMULHTVUxRTBwMESg{txOM3z6XVI{QDdzOUC1
SNB75MU\DfZRwfG:6aXOgRZN{[Xl?M1i3VVExOCEQvF2=MlPJOFghcA>?MVrHTVUxRTBwMEeg{txONFjYfWUzOzh5MUmwOS=>
SRMVjDfZRwfG:6aXOgRZN{[Xl?MXuxNFAh|ryPMkC1OFghcA>?NWWyTndOT0l3ME2wMlA{KM7:TR?=M17lblI{QDdzOUC1
TK10M1uzTGN6fG:2b4jpZ{BCe3OjeR?=MXixNFAh|ryPNWPxUWE6PDhiaB?=NFvKToNIUTVyPUCuNVgh|ryPNYHrO5U1OjN6N{G5NFU>
U251MoiyR5l1d3SxeHnjJGF{e2G7NVvxfYZDOTByIN88US=>Ml63OFghcA>?MVLHTVUxRTBwMESg{txOM{DNblI{QDdzOUC1
UACC257NYDlV5FrS3m2b4TvfIlkKEG|c3H5M174SFExOCEQvF2=NE\YXlQ1QCCqMmLoS2k2OD1yLkG0JO69VQ>?NV74elFMOjN6N{G5NFU>
UO31NXXhVWpyS3m2b4TvfIlkKEG|c3H5MoD5NVAxKM7:TR?=NXr0RXl5PDhiaB?=M{\ufmdKPTB;MD60PUDPxE1?NGnZVFAzOzh5MUmwOS=>
HaCaTNWnuOXNQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MkTJNlUh|rypL33MNY\veGxRPDhiaB?=M3\oR3RIUTVyPUCuOEDPxE1?MV:yN|g4PjN|OB?=
H9c2MWrGeY5kfGmxbjDBd5NigQ>?M1SwVVUh|ryPNULqRYFROjRiaB?=NG\xbW9CdnSrb4jp[IFvfCCjY4Tpeol1gSCjc4Pld5Nm\CCjczDpcpRz[W2rdH;jbI9v\HKrYXygVm9UKGyndnXsM2\3VVI{QTd|MkGz
H9c2MXXGeY5kfGmxbjDBd5NigQ>?NH73VYw2KM7:TR?=NWfPR3FYOjRiaB?=NVmwW2hVSW62aX;4bYRidnRiYXP0bZZqfHliYYPz[ZN{\WRiYYOgbY51emGlZXzseYxieiCvYXzvcplt\GmjbHTlbJll\SCuZY\lcC=>NIfDT2wzOzl5M{KxNy=>
H9c2MVnGeY5kfGmxbjDBd5NigQ>?M{XUN|Uh|ryPNX\Je40{OjRiaB?=MnP3RY51cW:6aXThcpQh[WO2aY\peJkh[XO|ZYPz[YQh[XNiaX70doFk\WyudXzhdkBTV1NibHX2[Yw>NFHCRW4zOzl5M{KxNy=>
H9c2NXrmbpJoTnWwY4Tpc44hSXO|YYm=NVHVdGRZPSEQvF2=M1rUclI1KGh?NX;2PI9vS2WubIXsZZIhfXC2YXvlNWTN[|dyOjN7N{OyNVM>
MCF7NXHyOYQ3TnWwY4Tpc44hSXO|YYm=MWi1JO69VQ>?MoP3NlQhcA>?MXfBcpRqd3irZHHueEBi[3Srdnn0fUBie3Onc4Pl[EBieyCrboTyZY1qfG:laH;u[JJq[WxiUl;TJIxmfmWuNGLPeFAzOzl5M{KxNy=>
MCF7Mn\xSpVv[3Srb36gRZN{[Xl?MkfBOUDPxE1?MXSyOEBpNV\XbpN4S2WubIXsZZIhfXC2YXvlMl7LNlM6PzN{MUO=
MCF7NF\4TIhHfW6ldHnvckBCe3OjeR?=M1fu[|Uh|ryPNXHU[2o2OjRiaB?=NWDCd5V2SW62aX;4bYRidnRiYXP0bZZqfHliYYPz[ZN{\WRiYYOgbY51emGlZXzseYxieiCvYXzvcplt\GmjbHTlbJll\SCuZY\lcC=>Ml7QNlM6PzN{MUO=
MCF7NHHYUotHfW6ldHnvckBCe3OjeR?=NUX1bZZMPSEQvF2=Ml33NlQhcA>?M33GTmNmdGy3bHHyJJVxfGGtZR?=NFLMcHMzOzl5M{KxNy=>
MDA-MB-231NFnRN5hHfW6ldHnvckBCe3OjeR?=NYHNZlJCPSEQvF2=MXOyOEBpM4jvUGNmdGy3bHHyJJVxfGGtZR?=NUXZdnppOjN7N{OyNVM>
MDA-MB-231NG\pdmdHfW6ldHnvckBCe3OjeR?=NIHsc2I2KM7:TR?=NEHsU|YzPCCqNHTjO4xCdnSrb4jp[IFvfCCjY4Tpeol1gSCjc4Pld5Nm\CCjczDpcpRz[WOnbHz1cIFzKG2jbH;ufYxlcWGuZHXofYRmKGyndnXsMWeyN|k4OzJzMx?=
MDA-MB-231NGjHeGlHfW6ldHnvckBCe3OjeR?=MoriOUDPxE1?MWmyOEBpMkjIRY51cW:6aXThcpQh[WO2aY\peJkh[XO|ZYPz[YQh[XNiaX70doFucXSxY3jvcoRzcWGuIGLPV{Bt\X[nbB?=M2ntV|I{QTd|MkGz
KB/HeLaM4DXZmN6fG:2b4jpZ{BCe3OjeR?=M3\vVlQ2KGh?NECwZlBGSzVyPUCuNlUh|ryPNFn4PWYzOzl6OEO1NS=>
HUVECMUXDfZRwfG:6aXOgRZN{[Xl?M33HWlQ5KGh?NH\SXGVKSzVyPUCuNFgxPyEQvF2=MUmyOFAyOjN5OB?=
HepG2NX;HPFVmTnWwY4Tpc44hSXO|YYm=MnrROFAh|rypL33MMVm0PEBpMoPFSG1UVw>?MXPJcohq[mm2aX;uJI9nKFSUSzD3bZRpKEmFNUCgc4YhOC5yMEK1JO69VQ>?NEL2R3MzPDBzM{SxNS=>
MRC5MkD5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M325[FczKGh?NGmxZodKSzVyPUCuNUDPxE1?NE[wcVIzPDB{MUS2Ni=>
HUVECMl;vSpVv[3Srb36gRZN{[Xl?NXPrZodYPSEQvF2=NFfUZpQzKGh?NGTCdYVE\WyudXzhdkB2eHSja3W=NWK1O5pWOjRyMki0OFY>
MDA-MB-435M2S2ZWN6fG:2b4jpZ{BCe3OjeR?=NGHWZoYyODBizszNMnHOOFghcA>?MX7JR|UxRTBwMUWg{txONUC4NWFmOjRyMki0OFY>
AS49-RAWMVPDfZRwfG:6aXOgRZN{[Xl?M1XaZlExOCEQvF2=NEm0T241QCCqMl;DTWM2OD1|Mj63PEDPxE1?NGfPS3YzPDB5N{WyPC=>
Caov3MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NHnQ[mU4OiCqNFzCXoRKSzVyPUCuNUDPxE1?MVuyOFA6PTB6OR?=
LNcaPMkfhSpVv[3Srb36gRZN{[Xl?NVnpNGpQOyEQvF2=MWKyOEBpMofLTY5kemWjc3Wgc4Yh[2ynYY\l[EBk[XOyYYPlMVkhdGW4ZXy=M{K3fFI1ODl3MEi5
LNcaPM1PDRWZ2dmO2aX;uJGF{e2G7MVmzJO69VQ>?MkT1NlQhcA>?NXTkd|ZjXXBvcnXneYxifGmxbjDv[kBxPTNiZYjwdoV{e2mxbh?=M3fne|I1ODl3MEi5
OVCAR8MnnBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NUCyNHZmOjBizszNMknVO|IhcA>?MXTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eR?=NIH1UWMzPDB7NUC4PS=>
U2OSNHXjV2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=Mn;nO|IhcA>?MXrJR|UxRTBwMzFOwG0>NGTFRnczPDB7NUC4PS=>
Caco2NFTFdoZEgXSxdH;4bYMhSXO|YYm=M4rDUVQxKM7:TR?=MV6yOEBpNYSxNVdJS3m2b4TvfIlkcXS7MX[yOFA6QTl7NB?=
MDA-MB-468NYT1TG4yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MmDTNVAh|ryPMl7HO|IhcA>?NFP3[2ZIUTVyPUCuNFg2KM7:TR?=MYKyOFE3Ozd{OR?=
Caco2NUj1ZlNmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=Ml7yOFghcA>?MkOxS2k2OD1yLkOyJO69VQ>?NUXYVZA6OjRzOESwO|Y>
MKN28NHr1XGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M{naSFQ5KGh?MnHBS2k2OD1yLkK0JO69VQ>?MX6yOFE5PDB5Nh?=
SGC7901NF\qeJdEgXSxdH;4bYMhSXO|YYm=MYjJR|UxRTBwMEGxJO69VQ>?NX6xdHNqOjRzOUW0OlY>
Bel7402NVPRR4E5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NUXZb|ZQQTZiaB?=NXnYeWhtTE2VTx?=NVOyVFRlUUN3ME2wMlU4QDJizszNNGru[oYzPDJzMU[zPS=>
CHP100NGfKTGNEgXSxdH;4bYMhSXO|YYm=MkSyO|IhcA>?MWTJR|UxRTBwN{mg{txOMor3NlQzPTF2MUe=
MGC803MY\DfZRwfG:6aXOgRZN{[Xl?NGHSb2g4OiCqM4nrS2lEPTB;MD6xO{DPxE1?MkDXNlQ{PzBzMUS=
ME180Mm[yR5l1d3SxeHnjJGF{e2G7Mor0OFghcA>?NF:4SIhKSzVyPUCuN|kh|ryPM3v6N|I1PDh5MUi4
L929MX;DfZRwfG:6aXOgRZN{[Xl?NV;xWXBwOS5zMDFOwG0>MnzsO|IhcA>?NHjWZ2NFVVORM2rId2lEPTB;MD6xOkDPxE1?M3vzelI1PTNyMEOw
MX1NIe0RllEgXSxdH;4bYMhSXO|YYm=NVnYXHo1OS5zMDFOwG0>NYDsc4hmPzJiaB?=MlTISG1UVw>?M4jjTGlEPTB;MD61JO69VQ>?MUWyOFU{ODB|MB?=
V79M4\R[GN6fG:2b4jpZ{BCe3OjeR?=MmHNNU4yOCEQvF2=NGjjTGI4OiCqM1juUmROW09?MYrJR|UxRTBwMkSg{txOMXGyOFU{ODB|MB?=
CCRF-CEMMX7DfZRwfG:6aXOgRZN{[Xl?M{nKcWROW09?NG\sd4lKSzVyPUCuNFA6KM7:TR?=MoXBNlQ2PjF4N{C=
CEM/ADR5000NHvhbldEgXSxdH;4bYMhSXO|YYm=MkLjSG1UVw>?NUT6TGJSS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hdXWudHnkdpVoNXKnc3nzeIFvfCCFRV2vRWRTPTByMDDj[YxteyCneIDy[ZN{cW6pIICt[4x6[2:ycn;0[YlvKHerdHigTWM2OCCxZjCyN{4zPyEQvF2=MoDwNlQ2PjF4N{C=
26-L5M3fCTGZ2dmO2aX;uJGF{e2G7NIrpfo03KGh?Mke1RY51cWmwdnHzbZZmKGGldHn2bZR6MUCyOFU6Ojl7Mx?=
BALB/3T3M3:2Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MWDJR|UxRTBwNTFOwG0>NIGxWIozPDZ|MUG5NC=>
16HBENX\GfXlCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NG\4c3MyOCEQvF2=M1nRVlczKGh?NV;HVlhJTE2VTx?=M1W1TmdKPTB;MD6xPEDPxE1?Mlq4NlQ3PTB4NEO=
HLFNUXIVlZTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M{nLWFExKM7:TR?=NFHDdmc4OiCqNX3ZZmZoTE2VTx?=NFnPbVRIUTVyPUCuN|Mh|ryPM3jwNFI1Pjh4MEGx
SGC7901NWD6b|RzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NITOTHEyOCEQvF2=NULtSWI1PzJiaB?=NXflbmZSTE2VTx?=MVvHTVUxRTBwNUWg{txONIHlNXIzPDZ6NkCxNS=>
A431M4nxZmN6fG:2b4jpZ{BCe3OjeR?=M{H1WGlEPTB;MD6wNFE{PSEQvF2=NVi0V4t1OjR6OUC2OVI>
HT-29NX;VUlk3TnWwY4Tpc44hSXO|YYm=MnvxNlUh|ryPNUfLbJJPOjRiaB?=M2jYT2lvcGmkaYTpc44hd2ZiTWLQN{1u\WSrYYTl[EBlenWpIILld4l{fGGwY3WgbY4h\G:6b4L1ZolkcW5vcnXzbZN1[W62IHj1cYFvKEiWLUK5JINmdGy|IHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKGS{dXegZYNkfW23bHH0bY9vMV[yOFkxODN|Nx?=
HT-29MoHOSpVv[3Srb36gRZN{[Xl?NHjUdVE2KM7:TR?=MYGyOEBpNIHqfXlKdmirYnn0bY9vKG:oIF3SVFMhcW5iZH;4c5J2[mmlaX6tdoV{cXO2YX70JIh2dWGwIFjUMVI6KGOnbHzzJIF{e2W|c3XkJIF{KG6rdILheIlwdiCxZjD0fZJwe2mwZTDy[ZNq\HWncx?=M4K2XVI1QTByM{O3
HT-29NYHyNZpjTnWwY4Tpc44hSXO|YYm=NEjoUHg2KM7:TR?=NX25TG9POSCqMlL3TY5pcWKrdHnvckBw\iCPUmCzMY1m\GmjdHXkJIRzfWdicnXzbZN1[W6lZTDpckBld3ixcoXibYNqdi2{ZYPpd5RidnRiaIXtZY4hUFRvMkmgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5kemWjc3WgbY4h\HK3ZzDhZ4N2dXWuYYTpc44>MUmyOFkxODN|Nx?=
HT-29NX:4dIhDTnWwY4Tpc44hSXO|YYm=MUi1JO69VQ>?Ml3rNUBpNX3Od3FXUW6mdXP0bY9vKG:oIH7peJJqfGVicILv[JVkfGmxbjDpckBld3ixcoXibYNqdi2{ZYPpd5RidnRiaIXtZY4hUFRvMkmgZ4VtdHN?NVH5O|JZOjR7MECzN|c>
NARNGjOWItHfW6ldHnvckBCe3OjeR?=NIjDN4o2KM7:TR?=MX2yJIg>MofpSJJ2\yC3cIThb4UhcW5iZH;4c5J2[mmlaX6tdoV{cXO2YX70JIh2dWGwIF7BVkBk\WyuIIDsZZNu[SCvZX3idoFv\Q>?NVHLPXVDOjR7MECzOFQ>
NARMV;DfZRwfG:6aXOgRZN{[Xl?NYfFUZV6OTBizszNM3zofVI1KGh?NUDzW5I6S3m2b4TvfIlkcXS7IHHzd4V{e2WmIHHzJIlv\HWldHnvckBw\iClZXzsJIRm[XSqNUn5[nFHOjR7MECzOFQ>
NARNFrpOnFEgXSxdH;4bYMhSXO|YYm=MW[xNFAh|ryPMnPhNlQhcA>?MUnDfZRwfG:6aXPpeJkh[WejaX7zeEBld3ixcoXibYNqdi2{ZYPpd5RidnRiaIXtZY4hVkGUIHPlcIx{KGG|c3Xzd4VlKGG|IHPlcIwhfmmjYnnsbZR6NUXiU2F2OjR7MECzOFQ>
DA-3NE\pZnJEgXSxdH;4bYMhSXO|YYm=NX;vU4EzPjBizszNNITQWHczPCCqNXXDdVd5UUN3ME20JO69VQ>?NHXFWYkzPDlyME[2PC=>
DA-3NXG2dGZ3TnWwY4Tpc44hSXO|YYm=Mn31NVAh|ryPMkS0NVAhcA>?MYfD[YxtfWyjcjD1dJRic2ViaX6gcY92e2ViRFGtN{Bk\WyuIH3peI9kcG:wZILpZS=>MnG4NlQ6ODB4Nki=
DA-3M2rYO2Z2dmO2aX;uJGF{e2G7MVOxNEDPxE1?NH\zVpoyOCCqMn\aR4VtdHWuYYKgeZB1[WunIHnuJI1wfXOnIFTBMVMh[2WubDDsfZNwe2:vZR?=NYfyT2tmOjR7MEC2Olg>
DA-3NYXlSFlyTnWwY4Tpc44hSXO|YYm=M2TTO|ExKM7:TR?=MX2xNEBpM3TSUWNmdGy3bHHyJJVxfGGtZTDpckBud3W|ZTDERU0{KGOnbHygcpVkdGW3cx?=NYjBdGFpOjR7MEC2Olg>
YOYO1NVPiUWFyTnWwY4Tpc44hSXO|YYm=NX61bmpCTGm|cHzhZ4Vu\W62IH;mJHlQYU9zIH\yc40heGijZ3WgcIFu[mSjIFTORUB4cXSqIFnDOVAhd2ZiMD62JO69VQ>?NUfXOGp4OjR7MEC2Olg>
KCL22MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NGDXW241QCCqNEX6R4lKSzVyPUGuPEDPxE1?Mm[4NlQ6PDFzMkm=
Saos2MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NFzj[401OCEQvF2=NEnET2ozPCCqNGLjVIdFVVORM17XNGlEPTB;MD6zN{DPxE1?NFLaV|QzPDl2MUGzNC=>
IMR32MV;DfZRwfG:6aXOgRZN{[Xl?NYe3bJRTOjVyIN88US=>NEjY[oo1QCCqNUfMSIlQTE2VTx?=NVPQWpJjUUN3ME2wMlAxPTFizszNNXzGdIg2OjR7OU[xOFA>
NTERA-S-cl-D1MknmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NHi3RXVKSzVyPUGuN|chdk1?NWnIPG9KW0GQR1XS
EW-16MojYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MoXyTWM2OD1zLkmxJI5OMWnTRW5ITVJ?
HUTU-80M3jheWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M{TtZmlEPTB;Mj6xNkBvVQ>?NVq0NGIxW0GQR1XS
KS-1MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M1nDZmlEPTB;Mz60OEBvVQ>?Mme0V2FPT0WU
HT-144NUj4e|dZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NGC2ZW5KSzVyPUOuOVEhdk1?Ml3YV2FPT0WU
MFH-inoM{njPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MnXVTWM2OD1|Lkm5JI5OMkj3V2FPT0WU
LC-2NUOy[3JbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M{GxTGlEPTB;NT6wO{BvVQ>?NVjCNFd{W0GQR1XS
SW982NEOz[o5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MoX0TWM2OD14LkC1JI5OMYLTRW5ITVJ?
ES4NWTjdW53T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NIHzRZBKSzVyPU[uNVEhdk1?Mn\hV2FPT0WU
KGNNXPPeHFLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M3nVOGlEPTB;Nj6zOEBvVQ>?MXjTRW5ITVJ?
RH-1M3XNVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7Mo\aTWM2OD14LkezJI5OM13QcHNCVkeHUh?=
IGROV-1M37Ie2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MmHFTWM2OD15LkKgcm0>MWTTRW5ITVJ?
KYSE-270M1HSN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NWO5O3lbUUN3ME23MlIyKG6PM3v4dHNCVkeHUh?=
TE-8NXzORZY{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MkC5TWM2OD15LkWgcm0>MknFV2FPT0WU
DaoyNXnpb|l[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NWjkVJdKUUN3ME24MlA4KG6PNIjDU2hUSU6JRWK=
REHNVToPWFiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NFrjR|ZKSzVyPUiuNVEhdk1?NIrOSmlUSU6JRWK=
786-0M{jvOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MUTJR|UxRThwNEegcm0>MmCwV2FPT0WU
A375NX23RWJOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MXLJR|UxRTlwMUegcm0>NIr6T4xUSU6JRWK=
EW-13NFXjd3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NFTyZZdKSzVyPUmuOlMhdk1?M3PRcnNCVkeHUh?=
MKN1NF3j[3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M1TPWGlEPTB;OT64OkBvVQ>?MljYV2FPT0WU
MV-4-11NVXzU4xwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NIT6dW1KSzVyPUGwMlA{KG6PMlzWV2FPT0WU
ESS-1MmXhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MVfJR|UxRTFzLkC5JI5OM3zreHNCVkeHUh?=
PSN1MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MXzJR|UxRTFzLkKyJI5ONWrBbFh7W0GQR1XS
MCF7MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?Ml\nTWM2OD1zMT62OUBvVQ>?M2rzeXNCVkeHUh?=
A427NYnkXmJlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NUHwTJM1UUN3ME2xNU45OSCwTR?=NXe5OXhZW0GQR1XS
NCI-H1651MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M2DRdmlEPTB;MUGuPFMhdk1?Mn22V2FPT0WU
LCLC-97TM1NXryWFZ[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M1[1fWlEPTB;MUGuPFMhdk1?NF7SN3FUSU6JRWK=
DU-4475M2riU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NVmyOIpsUUN3ME2xNk4yKG6PNGq1RnlUSU6JRWK=
SK-LU-1NG[1TYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NGL0fVVKSzVyPUGyMlU1KG6PNH;N[VRUSU6JRWK=
NCI-H460MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MVnJR|UxRTF{Lkegcm0>Mnq5V2FPT0WU
A204NFr0NotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NYjrS203UUN3ME2xNk45QCCwTR?=MoPQV2FPT0WU
AGSM{PWcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NVi4dHhKUUN3ME2xN{4zPyCwTR?=NGWyOY5USU6JRWK=
NCI-H2228NVLscHR1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M1O3UmlEPTB;MUOuOFghdk1?MULTRW5ITVJ?
HGC-27MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MX7JR|UxRTF|LkW2JI5OM1L3OHNCVkeHUh?=
RPMI-2650NVfHNmFqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M1PJZ2lEPTB;MUOuOlkhdk1?M1\GdHNCVkeHUh?=
ES1Mnz5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M1;H[WlEPTB;MUOuO|Ihdk1?NIXvZlZUSU6JRWK=
MEL-JUSONIPxcZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M4nHcWlEPTB;MUSuOUBvVQ>?NVTSU3dPW0GQR1XS
HT-1080NEf4VYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MnfLTWM2OD1zND64NkBvVQ>?NWD0[4EyW0GQR1XS
OCUB-MMYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MoHqTWM2OD1zNT6xOUBvVQ>?M4fmRXNCVkeHUh?=
23132-87MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NHjlemhKSzVyPUG1MlQzKG6PMUXTRW5ITVJ?
KYSE-510MlTMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NV\u[nV{UUN3ME2xOU41QCCwTR?=NEO4OI9USU6JRWK=
ST486NInLW4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MW\JR|UxRTF3LkWzJI5OM2DPenNCVkeHUh?=
639-VMonHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MWnJR|UxRTF3LkmxJI5ONH7aO|FUSU6JRWK=
COLO-679NFfr[pJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NVL5SHlVUUN3ME2xOU46PyCwTR?=MVPTRW5ITVJ?
CTV-1NIrCOZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MWHJR|UxRTF4LkC3JI5OM2rR[3NCVkeHUh?=
BFTC-905M1O1Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7Mo\XTWM2OD1zNj6xPEBvVQ>?NWjtb25nW0GQR1XS
SW954NInqc4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NWPwPXlUUUN3ME2xOk46OyCwTR?=M135dHNCVkeHUh?=
CAL-51MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NIXxcXpKSzVyPUG3MlMzKG6PNFTTVYtUSU6JRWK=
SW1710M3;mcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NXrWO|FTUUN3ME2xO{41KG6PM1;BWXNCVkeHUh?=
HCC2998MkXBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NYX1WlB5UUN3ME2xO{41PCCwTR?=M{jHdnNCVkeHUh?=
A2058NXrEdoJuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MUPJR|UxRTF5Lk[1JI5OM{m1V3NCVkeHUh?=
HCE-4NYSzOlFGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M4Ltc2lEPTB;MUiuNFchdk1?NICxbZRUSU6JRWK=
MEL-HONX3kNmdET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M1n6XWlEPTB;MUiuN{BvVQ>?M1nRd3NCVkeHUh?=
SNG-MNVfKUWRCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NIXEdmVKSzVyPUG4MlMzKG6PMorNV2FPT0WU
LS-123M2Tpd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MY\JR|UxRTF6LkS2JI5OMljtV2FPT0WU
NALM-6NVrWZndGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MV\JR|UxRTF6Lk[zJI5OMoPxV2FPT0WU
NCI-H810M4fON2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NH63SolKSzVyPUG4Mlc3KG6PMkfRV2FPT0WU
YKG-1M1TGO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NIPLcIdKSzVyPUG4Mlc4KG6PNYPmcohXW0GQR1XS
647-VMlTBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MXjJR|UxRTF6LkixJI5OMWXTRW5ITVJ?
ONS-76M2fEWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NEP3dXRKSzVyPUG4MlkyKG6PMUXTRW5ITVJ?
697M4XIeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M1zmfWlEPTB;MUmuNFkhdk1?M1fJcnNCVkeHUh?=
RS4-11MlL0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NUjnNVVJUUN3ME2xPU4yPCCwTR?=M4L4TXNCVkeHUh?=
8505CMWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M4[5T2lEPTB;MUmuOVYhdk1?NX;BTJJPW0GQR1XS
SK-UT-1M3;NO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NVTRcmk5UUN3ME2xPU46PiCwTR?=MV;TRW5ITVJ?
DOHH-2M4HXXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NXLaUHQ5UUN3ME2xPU46QSCwTR?=MmSxV2FPT0WU
NCCITMmPuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NY\uPW1GUUN3ME2yNE4yOyCwTR?=MmWyV2FPT0WU
LCLC-103HMlHnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MnzKTWM2OD1{MD61OEBvVQ>?M2CxZnNCVkeHUh?=
CAL-12TM3\jWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MkG1TWM2OD1{MD62OUBvVQ>?MnfTV2FPT0WU
QIMR-WILNVf6WYV[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NVXhPW5HUUN3ME2yNE44OiCwTR?=NVHtVIxGW0GQR1XS
SBC-5M17tUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M4XGc2lEPTB;MkCuO|Qhdk1?NFLWNIVUSU6JRWK=
769-PNYT0e5BnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NUjNcFVXUUN3ME2yNE44PiCwTR?=M361cHNCVkeHUh?=
A431MmTBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MlnSTWM2OD1{MD64O{BvVQ>?NHL6W49USU6JRWK=
KE-37MoC4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M4HCZWlEPTB;MkGuNFUhdk1?M3foPHNCVkeHUh?=
ES8NYnE[2dPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M4jKO2lEPTB;MkGuNFchdk1?M1z5UnNCVkeHUh?=
22RV1MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MW\JR|UxRTJzLkK0JI5OM2HxU3NCVkeHUh?=
LOUCYMYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NEXPWFJKSzVyPUKxMlMzKG6PNF[wTlFUSU6JRWK=
J82MkPlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MlvZTWM2OD1{MT6zOEBvVQ>?NIfNRmZUSU6JRWK=
MHH-ES-1MoO5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MnTrTWM2OD1{MT61PEBvVQ>?NH7XPZlUSU6JRWK=
MG-63MlnSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NUP4UXZsUUN3ME2yNk4xQCCwTR?=M3\tRnNCVkeHUh?=
8-MG-BANIi3R5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NIfzVFFKSzVyPUKyMlEzKG6PM3S3d3NCVkeHUh?=
BPH-1NIrybXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MYfJR|UxRTJ{LkGyJI5OMl[3V2FPT0WU
RKOM1vZR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NHLYWJpKSzVyPUKyMlI5KG6PMVTTRW5ITVJ?
HMV-IIMW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NVT1ZYdGUUN3ME2yNk43KG6PNIn0fGpUSU6JRWK=
NCI-H727NFvtOWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M3qzdmlEPTB;MkKuO|khdk1?M3;RPHNCVkeHUh?=
MOLT-4MlfVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MYjJR|UxRTJ{Lki2JI5ONXjkNIlyW0GQR1XS
NCI-H2342NXH1bYMyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M1LFdmlEPTB;MkKuPVEhdk1?M3rKOHNCVkeHUh?=
MZ1-PCNV;KVop6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MWjJR|UxRTJ|LkixJI5OMVnTRW5ITVJ?
TE-15NEjYUFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=Mn7hTWM2OD1{ND6xOEBvVQ>?MmL4V2FPT0WU
SRM3i0SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M3PsNWlEPTB;MkSuOFEhdk1?MWjTRW5ITVJ?
CCRF-CEMMmfRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NHTRSI5KSzVyPUK0MlUzKG6PNF7RNXZUSU6JRWK=
SIG-M5NV7HU3lmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NIr1TGdKSzVyPUK1MlY6KG6PMYXTRW5ITVJ?
SK-PN-DWMm[1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MlWyTWM2OD1{NT63NkBvVQ>?NVjhclJPW0GQR1XS
SK-HEP-1NWHVOYZXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NEG4NplKSzVyPUK1Mlg3KG6PNHjWWplUSU6JRWK=
SW620MlSwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MVLJR|UxRTJ4Lk[zJI5ONELwOopUSU6JRWK=
HSC-2Mn\FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?Mk\0TWM2OD1{Nj63PEBvVQ>?NUfZfGhvW0GQR1XS
CAL-148NY[2PXVYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MmC5TWM2OD1{Nj65JI5OMXzTRW5ITVJ?
COLO-205MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NEHPUoxKSzVyPUK2Mlk6KG6PMXLTRW5ITVJ?
EoL-1-cellNFfDdHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NI\CSIZKSzVyPUK3Mlc5KG6PMn\YV2FPT0WU
KYSE-150MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M4L0dGlEPTB;MkeuO|ghdk1?M4f1PHNCVkeHUh?=
G-361M2Lub2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7M2TwXmlEPTB;MkiuPFghdk1?NWezN4s4W0GQR1XS
PANC-03-27NITxR3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NWTHbphxUUN3ME2yPE4yPiCwTR?=M3LhbXNCVkeHUh?=
NCI-H2030MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NWn6XodsUUN3ME2yPE4zPiCwTR?=M3PaOXNCVkeHUh?=
NCI-H441M3L0RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NXO2T5hnUUN3ME2yPE41OiCwTR?=Mk[3V2FPT0WU
A388MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M4jPZmlEPTB;MkiuOFYhdk1?NWi3fXVDW0GQR1XS
BHYM2HEOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NWrleWE3UUN3ME2yPE45QCCwTR?=NITibWdUSU6JRWK=
KALS-1NVTqeGNoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MWfJR|UxRTJ7LkOzJI5OM4fWUnNCVkeHUh?=
NKM-1NFPrOGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=Moq3TWM2OD1{OT60O{BvVQ>?NVLFfGx1W0GQR1XS
BB30-HNCMoLIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NV3tZZlrUUN3ME2yPU45PSCwTR?=MUHTRW5ITVJ?
G-401NInsR4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MXLJR|UxRTNyLkKgcm0>MVrTRW5ITVJ?
EW-7MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MXXJR|UxRTNyLk[zJI5OMXLTRW5ITVJ?
CANMk\4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MkXiTWM2OD1|MT6xNkBvVQ>?NHy0UIdUSU6JRWK=
M059JNHzSOGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NF\v[GlKSzVyPUOxMlM4KG6PNIXkXHNUSU6JRWK=
SK-MES-1MmnLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M3;PemlEPTB;M{GuOUBvVQ>?Mm\UV2FPT0WU
5637NH;yVlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M4noTWlEPTB;M{GuPFchdk1?MkfsV2FPT0WU
MKN28M1vSZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NInreJJKSzVyPUOxMlkyKG6PMonDV2FPT0WU
COR-L23NEX0UXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MVrJR|UxRTNzLkm2JI5OMXnTRW5ITVJ?
CAL-27MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MkDzTWM2OD1|Mj61O{BvVQ>?MYHTRW5ITVJ?
CAL-62MorkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MVvJR|UxRTN{Lke5JI5OM4LJWnNCVkeHUh?=
C-33-AMXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NXHuVot{UUN3ME2zNk45QSCwTR?=MkTtV2FPT0WU
RT-112MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NF3ZcZVKSzVyPUOyMlkzKG6PNY\oelNNW0GQR1XS
KU812MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NFfDVZNKSzVyPUOzMlI1KG6PMnr1V2FPT0WU
C8166M2DxTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7Mn7JTWM2OD1|Mz6zNUBvVQ>?MmjpV2FPT0WU
VA-ES-BJNX\JOpRET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NWjxdY42UUN3ME2zN{4{PiCwTR?=NYTwWpJJW0GQR1XS
NEC8NHfqVXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MnfiTWM2OD1|Mz62NUBvVQ>?MlrGV2FPT0WU
EB2NHfYR|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M2q4b2lEPTB;M{OuO|Mhdk1?MmHiV2FPT0WU
COLO-680NMYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NV;YPXNLUUN3ME2zN{45PyCwTR?=MU\TRW5ITVJ?
IGR-1Moq5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NH\YdJFKSzVyPUOzMlg{KG6PNYXk[nYyW0GQR1XS
MZ2-MELMVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?Mon1TWM2OD1|Mz65NkBvVQ>?M{nWOHNCVkeHUh?=
MIA-PaCa-2NI\vSpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MoXJTWM2OD1|ND6yOEBvVQ>?NGDDd45USU6JRWK=
IMR-5NXTI[HNvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NVexNVh2UUN3ME2zOE43QCCwTR?=NV;YRVZVW0GQR1XS
CHP-212M{XFXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MnzjTWM2OD1|ND65OkBvVQ>?NHHPV|lUSU6JRWK=
CCF-STTG1M3Wx[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MY\JR|UxRTN3LkWgcm0>NUO4PIJnW0GQR1XS
SK-MEL-30M4Tyb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NVLI[2dzUUN3ME2zOU43OSCwTR?=NXWzdW9DW0GQR1XS
HLEM4P2dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M4nTSmlEPTB;M{WuPEBvVQ>?NW\WbnhIW0GQR1XS
HOP-62NUizcolqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MUfJR|UxRTN3Lki4JI5OMoXiV2FPT0WU
LB1047-RCCNHTxNZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M1\QWmlEPTB;M{WuPVchdk1?Mki3V2FPT0WU
DoTc2-4510MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MYnJR|UxRTN4LkK1JI5OMXrTRW5ITVJ?
HT-29MnzNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MX;JR|UxRTN4LkW3JI5OM2q1TXNCVkeHUh?=
HC-1NXH3OVVqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NGfmUmlKSzVyPUO3MlMzKG6PNIDyOVdUSU6JRWK=
TE-5MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NFjKZlhKSzVyPUO3MlQ5KG6PMkS5V2FPT0WU
NCI-H1299NXvjXGZMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NEm3VXhKSzVyPUO3MlU6KG6PNHfRXWpUSU6JRWK=
CHL-1MlXGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MljKTWM2OD1|Nz63N{BvVQ>?NEnmTGlUSU6JRWK=
NCI-H2122M17hRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MW\JR|UxRTN5Lkmgcm0>M4H5dHNCVkeHUh?=
DELNIXtZYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M4HmPWlEPTB;M{iuOFQhdk1?MojqV2FPT0WU
ES5M4LLU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MVrJR|UxRTN7LkKyJI5ONHfnNYJUSU6JRWK=
CESSNEnlRYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MkDNTWM2OD1|OT6zOkBvVQ>?NWX3NYQ4W0GQR1XS
NCI-H719M4[zd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7Mn7NTWM2OD1|OT62OUBvVQ>?M3G0WHNCVkeHUh?=
A3-KAWMlLZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NGTGfZNKSzVyPUSwMlE1KG6PMo\1V2FPT0WU
KP-4NFrVNVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MWfJR|UxRTRyLke3JI5ONH7oVnRUSU6JRWK=
NCI-H358NFnKRZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NIDtfHhKSzVyPUSxMlA5KG6PM1nlZ3NCVkeHUh?=
HCC38NVvGWXVYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MVrJR|UxRTR{LkWgcm0>NVvsbHRRW0GQR1XS
MRK-nu-1M{n0eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7Ml\6TWM2OD12Mz62OkBvVQ>?NHK5TmpUSU6JRWK=
NCI-H292MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NGmyOYpKSzVyPUSzMlc3KG6PM3PlOHNCVkeHUh?=
PA-1M2DH[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NVzt[2JnUUN3ME20OE41QCCwTR?=MlqwV2FPT0WU
CAL-85-1NGi3O2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NGi3OoFKSzVyPUS0MlUzKG6PMUXTRW5ITVJ?
KYSE-450MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M1fkc2lEPTB;NESuO|Ehdk1?NYG3SWRvW0GQR1XS
IST-MEL1NEPKWY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M3u3Z2lEPTB;NESuPFQhdk1?MXvTRW5ITVJ?
Ca-SkiMmfES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NIe0RY9KSzVyPUS0Mlg1KG6PMo[0V2FPT0WU
OCI-AML2M2TrVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MXTJR|UxRTR3LkC1JI5ONGjzZmVUSU6JRWK=
NUGC-3MnzPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MX3JR|UxRTR3LkKgcm0>NUDwcIM5W0GQR1XS
HOSM{HNfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NGfCe3NKSzVyPUS1MlI6KG6PMoG1V2FPT0WU
NB1M3O3Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NGTTTY9KSzVyPUS1Mlk6KG6PMV3TRW5ITVJ?
A253NFfmXYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NEfHeY9KSzVyPUS2MlEzKG6PMVHTRW5ITVJ?
NCI-H209MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NYfVZXhuUUN3ME20PE44OyCwTR?=M2PETXNCVkeHUh?=
MC-CARM3zsNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M{jFN2lEPTB;NEiuO|Qhdk1?M3PFbXNCVkeHUh?=
NCI-H661MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NVy2S4E5UUN3ME20PU4xOyCwTR?=M4G2UHNCVkeHUh?=
SF295MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M4XE[mlEPTB;NEmuNFghdk1?MoTjV2FPT0WU
GP5dNUjoSVNFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NWizWGQ{UUN3ME20PU4yOiCwTR?=M3LYdXNCVkeHUh?=
P12-ICHIKAWAMnPMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NXPxTFhWUUN3ME20PU4zPyCwTR?=NGTLTndUSU6JRWK=
ACHNMln6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NYPie2x[UUN3ME20PU4{PCCwTR?=MoftV2FPT0WU
NCI-H2087NGPudlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NUP0PIdJUUN3ME20PU41OiCwTR?=Mnq4V2FPT0WU
SW48Mo\zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NVG2WHlkUUN3ME20PU44OiCwTR?=NIHHPZBUSU6JRWK=
NCI-H526M{X2cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MmPiTWM2OD12OT65OkBvVQ>?MWrTRW5ITVJ?
Ca9-22M3zLdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NEXsXZVKSzVyPUWwMlA4KG6PM3u0T3NCVkeHUh?=
SK-OV-3M1Tp[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MXHJR|UxRTVyLkGyJI5ONFTVbYJUSU6JRWK=
KYSE-140M2P4XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MUTJR|UxRTVyLkSyJI5ONGm0NJBUSU6JRWK=
BE-13NYjJVGVVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MWrJR|UxRTVzLkCyJI5ONUDUZ|hwW0GQR1XS
ES7M3\xU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MlrXTWM2OD13MT60JI5ONVLrd3R[W0GQR1XS
IM-9MlnkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MkfaTWM2OD13MT60N{BvVQ>?MnS2V2FPT0WU
A101DNXj5UnpvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NGjFRpJKSzVyPUWxMlQ5KG6PNHm1TWtUSU6JRWK=
CAPAN-1MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NFXjSVVKSzVyPUWxMlc3KG6PNW\YN5dZW0GQR1XS
NCI-H2009NGfkV4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NX3qXHBNUUN3ME21NU44PiCwTR?=NWLYOJl1W0GQR1XS
NCI-H522NVrU[lMyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NV3FUHhrUUN3ME21NU46OyCwTR?=MWrTRW5ITVJ?
HuP-T4MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MUPJR|UxRTV{LkKyJI5OMXLTRW5ITVJ?
BCPAPMV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NXHuVWdLUUN3ME21Nk42KG6PMXnTRW5ITVJ?
NCI-H1734NV\nVW12T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MoHYTWM2OD13MzDuUS=>NW\IeGNrW0GQR1XS
SK-LMS-1Mn:1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?Mn7XTWM2OD13Mz6yNkBvVQ>?NXSxUm5oW0GQR1XS
CGTH-W-1M{LTcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M3vpdGlEPTB;NUOuOFYhdk1?MlnDV2FPT0WU
RPMI-8402MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NEfmb|hKSzVyPUWzMlg3KG6PM3vpOHNCVkeHUh?=
Calu-3MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NH7NSWZKSzVyPUW1Mlk5KG6PNGfUXmtUSU6JRWK=
COR-L279NUKyN|VqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NF\NNGhKSzVyPUW2Mlk2KG6PM3\Hc3NCVkeHUh?=
T84MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MWnJR|UxRTV5LkC2JI5OMmnWV2FPT0WU
P30-OHKMXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NVXpXmYxUUN3ME21O{42PyCwTR?=MmTmV2FPT0WU
CHP-126MoGxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NX6zbmtYUUN3ME21PU4zPCCwTR?=M1vPe3NCVkeHUh?=
KYSE-180MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MlTVTWM2OD13OT63OUBvVQ>?MYPTRW5ITVJ?
CAMGMYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MV\JR|UxRTV7Lkm2JI5ONF\Kc5RUSU6JRWK=
EW-1M1LTNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MWDJR|UxRTZzLkO1JI5OMULTRW5ITVJ?
OVCAR-8NH7jOHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NYTOboVQUUN3ME22NU46OiCwTR?=M3faXHNCVkeHUh?=
HL-60MmHIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MX;JR|UxRTZ{LkW2JI5OMlOyV2FPT0WU
8305CMYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NHHIR2RKSzVyPU[zMlEzKG6PNWfwZndGW0GQR1XS
IA-LMMX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MoPFTWM2OD14Mz61OEBvVQ>?NHW5NIZUSU6JRWK=
HCC2157M1;n[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MoK3TWM2OD14Mz65OUBvVQ>?MX3TRW5ITVJ?
CTB-1MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NUPkRZVZUUN3ME22OFAyQSCwTR?=NUjJc2NIW0GQR1XS
NCI-H1437NYP1bHpzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M4nGTGlEPTB;NkSuOlQhdk1?NHu4RnFUSU6JRWK=
U251MmHPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MVzJR|UxRTZ2Lki5JI5ONYG0dFdMW0GQR1XS
ALL-POM2jOdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M2WwfmlEPTB;NkWuNFMhdk1?MXPTRW5ITVJ?
NCI-SNU-1NGPGSpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M2H1fGlEPTB;NkWuPFYhdk1?MWXTRW5ITVJ?
RPMI-6666MnHWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NWLWdnc4UUN3ME22OU46QSCwTR?=M4LMbXNCVkeHUh?=
DBTRG-05MGNV63RW5kT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NV;FenlQUUN3ME22O{4yOSCwTR?=NW\ORphtW0GQR1XS
PF-382NET3W3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NXfFdZFNUUN3ME22O{4yPyCwTR?=NF;pNoJUSU6JRWK=
GT3TKBNV3lUVZzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NEL6RWtKSzVyPU[3MlE6KG6PMXvTRW5ITVJ?
SCC-3NVLMeXVoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MUjJR|UxRTZ5LkK4JI5OMWPTRW5ITVJ?
LU-134-AMmfYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NHvK[4xKSzVyPU[3MlY5KG6PMVLTRW5ITVJ?
CAL-33NFTtcphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NF;KRolKSzVyPU[3Mlg4KG6PMkTlV2FPT0WU
MC-IXCM3XUUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NWLDPItKUUN3ME22O{46KG6PNGn3NIxUSU6JRWK=
CPC-NNVnlXlRGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NWD5d|dpUUN3ME22PE41KG6PNHfNW3pUSU6JRWK=
A2780MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NGLqeItKSzVyPU[4Mlc6KG6PMnXFV2FPT0WU
DaudiNG\zWG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NYLjPXBEUUN3ME22PE46PiCwTR?=NEHVVJdUSU6JRWK=
GI-1M1jYR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NF3qcmlKSzVyPU[5MlY2KG6PMWnTRW5ITVJ?
SW962MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MkfrTWM2OD14OT65OUBvVQ>?M2e0UHNCVkeHUh?=
MFE-296NGfM[VdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MV;JR|UxRTdyLkS5JI5ONWTlZpRnW0GQR1XS
H4MkTUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MXXJR|UxRTdzLkW2JI5ONXuzSlVyW0GQR1XS
AN3-CAMnOwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M1:3VGlEPTB;N{KuN|Ihdk1?MVXTRW5ITVJ?
HCC1599NYDwZZBnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M3zaWWlEPTB;N{KuOVQhdk1?NYnmelNJW0GQR1XS
HuCCT1MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MmHkTWM2OD15Mj65N{BvVQ>?MoHRV2FPT0WU
Calu-1NGTLVJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NEH3UYZKSzVyPUezMlYhdk1?M3;wVnNCVkeHUh?=
DU-145MlGwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MVTJR|UxRTd|LkezJI5OMV\TRW5ITVJ?
IST-SL2NWfHWVBjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NGn5T5dKSzVyPUezMlgyKG6PM1yyNnNCVkeHUh?=
HSC-3MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NHq3RWZKSzVyPUe0MlU{KG6PMlT1V2FPT0WU
HCC1806NF\sZVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NVnaTox2UUN3ME23OE46PiCwTR?=NVL0fZp6W0GQR1XS
VM-CUB-1M1TMT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NYHPVldCUUN3ME23OU4{PiCwTR?=NULTNFZ3W0GQR1XS
HSC-4M3\6d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NGnjVnhKSzVyPUe1Mlc3KG6PNWC0dYJDW0GQR1XS
NH-12MmXYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MVfJR|UxRTd4IH7NMUXTRW5ITVJ?
MDA-MB-468MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?Mmr6TWM2OD15Nj6xPEBvVQ>?Ml3wV2FPT0WU
TURM{LCZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7Mk\LTWM2OD15Nj6zNkBvVQ>?MXTTRW5ITVJ?
TE-1MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MlSwTWM2OD15Nj6zOUBvVQ>?M2q5eHNCVkeHUh?=
CMKM4\5N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MXzJR|UxRTd5LkSyJI5OM1nienNCVkeHUh?=
LB996-RCCMYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NFnZZmpKSzVyPUe4MlQ2KG6PNYnzSWczW0GQR1XS
NCI-H1650MojWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M2nH[mlEPTB;N{iuOlIhdk1?NXPnXGFNW0GQR1XS
DMS-273M120Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NUTKW2d6UUN3ME23PE46KG6PNEXIRo1USU6JRWK=
NOS-1MlGzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NV3JUFJoUUN3ME23PU4yPCCwTR?=M1qxWHNCVkeHUh?=
NB69M1fDdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MonpTWM2OD15OT6yJI5OMXLTRW5ITVJ?
SUP-T1M{[3V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NHn4cmtKSzVyPUe5MlczKG6PMkPwV2FPT0WU
A172MmjoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MnXNTWM2OD16MD61OUBvVQ>?MXnTRW5ITVJ?
TE-12Ml3QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MWTJR|UxRThzLkC2JI5OM3jSWXNCVkeHUh?=
MKN45M3LMcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MkG0TWM2OD16MT61NUBvVQ>?NVjCW|F1W0GQR1XS
LoVoMVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MWHJR|UxRThzLkiyJI5OM2\zPHNCVkeHUh?=
SW1573NUHtdoYxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M3qyRmlEPTB;OEKuPFEhdk1?M4LOWXNCVkeHUh?=
ETK-1Mn;rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MWDJR|UxRTh|LkCxJI5OM2LKNHNCVkeHUh?=
ABC-1NWnTdVRzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MnvmTWM2OD16Mz60OUBvVQ>?MoDBV2FPT0WU
COLO-668NGq3NoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NUnufmNYUUN3ME24OE41PyCwTR?=MXjTRW5ITVJ?
UM-UC-3MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NEXacHpKSzVyPUi2MlAzKG6PNXLPcoIxW0GQR1XS
BC-1MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NHq5V2VKSzVyPUi2Mlc3KG6PMVnTRW5ITVJ?
PANC-10-05NH3ETHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NWOxZZFVUUN3ME24PE41PSCwTR?=MX;TRW5ITVJ?
ES3NUPDeJViT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NGnSdFRKSzVyPUi5MlQ5KG6PMV\TRW5ITVJ?
TE-441-TMUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M1zBTWlEPTB;OEmuPFIhdk1?MmTjV2FPT0WU
KM-H2NVG0ZYZRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MXXJR|UxRTlyLk[4JI5ONHv2WndUSU6JRWK=
SH-4NVTNOng6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MmDzTWM2OD17Mj6xNUBvVQ>?M2PDRXNCVkeHUh?=
SF268NGTPb|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NHOxemtKSzVyPUmyMlQzKG6PMXHTRW5ITVJ?
VMRC-RCZNWPHR5NOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NFXEblBKSzVyPUmzMlI3KG6PM3PjUXNCVkeHUh?=
GI-ME-NM4LxUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7Mn3VTWM2OD17Mz6zN{BvVQ>?Ml7FV2FPT0WU
JEG-3MlOyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MV3JR|UxRTl3LkGyJI5ONGLzZ49USU6JRWK=
J-RT3-T3-5M3;VS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MUHJR|UxRTl4LkOxJI5OMUjTRW5ITVJ?
K5MoH1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M{L4VmlEPTB;OU[uPUBvVQ>?M3e4VnNCVkeHUh?=
EFO-27MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MXXJR|UxRTl5LkS0JI5ONWr6RlVxW0GQR1XS
SW1783MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MkHQTWM2OD17Nz65PUBvVQ>?NIfsTmxUSU6JRWK=
CAL-39MmD0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NVi4TZo5UUN3ME25PE4zPCCwTR?=M2HNXnNCVkeHUh?=
LS-441NMWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MmfZTWM2OD17OT6wOkBvVQ>?NEezWZBUSU6JRWK=
G-402MoW2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NH[2Wo1KSzVyPUm5MlA6KG6PMWnTRW5ITVJ?
MES-SANG\pN5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M3PMSGlEPTB;OUmuOVMhdk1?MmjiV2FPT0WU
FADUNI\rO5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MUXJR|UxRTFyMj6xPEBvVQ>?NYDyVWo5W0GQR1XS
DJM-1NX;yNFlDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MX3JR|UxRTFyMj6yOUBvVQ>?NInGeIlUSU6JRWK=
SU-DHL-1MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NXPQU4hmUUN3ME2xNFIvPSCwTR?=NGnKNXJUSU6JRWK=
KYSE-410M4nNN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NUPoWmw2UUN3ME2xNFMvPDZibl2=MWjTRW5ITVJ?
NCI-H1618M1HNXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NX;LNGh[UUN3ME2xNFQvOzVibl2=MVjTRW5ITVJ?
AU565M1HQWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NFH2UotKSzVyPUGwOE42OSCwTR?=MXnTRW5ITVJ?
SF126NH;OeZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NWLQfoh3UUN3ME2xNFQvPThibl2=M3\SdHNCVkeHUh?=
MMAC-SFNYrwXmZrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MXfJR|UxRTFyNj60PEBvVQ>?M1voc3NCVkeHUh?=
ChaGo-K-1NWrPcpZOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NYj3ZZVKUUN3ME2xNFcvQTVibl2=NFm0fJlUSU6JRWK=
NCI-H596MkTOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M1W0dGlEPTB;MUC4MlAyKG6PMX7TRW5ITVJ?
LXF-289Mn25S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MnH0TWM2OD1zMEmuNlQhdk1?M{DWUnNCVkeHUh?=
HCC1569M1vUfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NE\LeGxKSzVyPUGwPU4{PCCwTR?=M3fLenNCVkeHUh?=
NCI-H2170M3XPdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MnnNTWM2OD1zMEmuPVIhdk1?NXS1WGNvW0GQR1XS
ARH-77MlS3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MonKTWM2OD1zMEmuPVkhdk1?M1y2OXNCVkeHUh?=
BOKUNH;HenhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MUnJR|UxRTFzMD64O{BvVQ>?M1r5S3NCVkeHUh?=
SJSA-1NVH5UFdiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NED1ZmtKSzVyPUGxNU4xPSCwTR?=M2Pm[3NCVkeHUh?=
SW626NHe2W3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MmjRTWM2OD1zMUGuO|Ehdk1?NGXJdFVUSU6JRWK=
EHEBMX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M3fueWlEPTB;MUGyMlU6KG6PMWrTRW5ITVJ?
TE-10Mn\MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NFTtUpJKSzVyPUGxNk43QCCwTR?=MXrTRW5ITVJ?
MZ7-melNXvDdGd[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M4PIfmlEPTB;MUGyMlg1KG6PMVHTRW5ITVJ?
SASNYL1S3c{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NWTwTG13UUN3ME2xNVQvPDVibl2=MYDTRW5ITVJ?
TK10MmmwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NHTHb3pKSzVyPUGxOE43KG6PNWDNU4poW0GQR1XS
SW13MnT0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M{TBSGlEPTB;MUG1MlI3KG6PM4\XSnNCVkeHUh?=
HCC1937M17ySWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7Mo[3TWM2OD1zMUWuPFQhdk1?M4XXR3NCVkeHUh?=
SK-NEP-1M17kSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M37sZWlEPTB;MUG2MlI3KG6PNXf6dG9VW0GQR1XS
OVCAR-5MmP3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MWDJR|UxRTFzNj64NUBvVQ>?MoHMV2FPT0WU
SW837Mli5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MWPJR|UxRTFzNz65OUBvVQ>?MYjTRW5ITVJ?
BFTC-909M4ewNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NVfZcpd7UUN3ME2xNVgvPDhibl2=M4HIV3NCVkeHUh?=
SW872NWD4WVNpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MWrJR|UxRTF{MD64NUBvVQ>?M331fXNCVkeHUh?=
SF539MkfUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M3jsbGlEPTB;MUKxMlczKG6PMUPTRW5ITVJ?
MLMANWTpT|ZqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NGD0bGxKSzVyPUGyNk4xQCCwTR?=MlPmV2FPT0WU
BL-41MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NIGwT|JKSzVyPUGyNk4zOiCwTR?=NUnEVpN7W0GQR1XS
LB647-SCLCM4r2bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MmTFTWM2OD1zMkOuN|Uhdk1?NGrHUnJUSU6JRWK=
NCI-H1703MorkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NIjlUGFKSzVyPUGyOk41OiCwTR?=MV3TRW5ITVJ?
KURAMOCHINHi1NpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MkX0TWM2OD1zMk[uO|Yhdk1?M1PpUXNCVkeHUh?=
ATN-1M3X5XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NHHNTGNKSzVyPUGyO{44KG6PNVLxNVlSW0GQR1XS
SK-CO-1NHzFUoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NWS3WnllUUN3ME2xNlkvOjFibl2=M3LEenNCVkeHUh?=
RPMI-7951Ml\5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NXzVUnJsUUN3ME2xN|AvOTRibl2=MnzoV2FPT0WU
NCI-H1648MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MVrJR|UxRTF|MT65OEBvVQ>?Ml34V2FPT0WU
NCI-H64NGXIUJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MVfJR|UxRTF|Mj62OUBvVQ>?MlXMV2FPT0WU
HT-3MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MmDYTWM2OD1zM{OuNFQhdk1?NHTzSmhUSU6JRWK=
NCI-H1770M1n0UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M1TLdGlEPTB;MUOzMlIyKG6PMXXTRW5ITVJ?
NB13NFzrU|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MnrmTWM2OD1zM{SuOVUhdk1?M3PabHNCVkeHUh?=
NCI-H747NGn4Tm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MUPJR|UxRTF|NT6wNkBvVQ>?NILtdVFUSU6JRWK=
ML-2NXWzVYZuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NFy3fYRKSzVyPUGzOU4yPiCwTR?=NULsZ5E4W0GQR1XS
CA46MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MnW2TWM2OD1zM{[uPFghdk1?MoW2V2FPT0WU
ES6MmLFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M3XvSGlEPTB;MUO3MlEzKG6PM2rtfXNCVkeHUh?=
JiyoyeP-2003M37nVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NVvKXHp1UUN3ME2xN|cvQCCwTR?=MWTTRW5ITVJ?
NMC-G1NH20No5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MWrJR|UxRTF|OT6xN{BvVQ>?NXHncFdqW0GQR1XS
U-698-MM4jROmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MXPJR|UxRTF|OT61JI5ONG\oZpVUSU6JRWK=
LU-99ANWW4bZJ7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M3\KdWlEPTB;MUS2MlU2KG6PNEP0ZW9USU6JRWK=
NCI-H748NF\JXpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MoPnTWM2OD1zNEeuN|Ehdk1?M4LtVHNCVkeHUh?=
SK-MEL-3MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MVPJR|UxRTF2Nz62NUBvVQ>?M1vPUnNCVkeHUh?=
SNB75MmSzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NHLKVlVKSzVyPUG0PE43PSCwTR?=MYrTRW5ITVJ?
BB65-RCCNX;NUnF7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M4i3TWlEPTB;MUS5MlMyKG6PMYDTRW5ITVJ?
NCI-H1355MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MXLJR|UxRTF3Mj6yOEBvVQ>?NWrqdoVzW0GQR1XS
SCC-25M1;iemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NXGx[JpTUUN3ME2xOVMvPzNibl2=NX\hT5dmW0GQR1XS
OAW-42M1z0NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NXPp[3k{UUN3ME2xOVMvQDRibl2=Mn\hV2FPT0WU
MONO-MAC-6MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MnXnTWM2OD1zNUSuN|Yhdk1?NYLUZ|N3W0GQR1XS
WSU-NHLMkKxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?Ml;ZTWM2OD1zNUSuOVghdk1?M1zqe3NCVkeHUh?=
SNU-423MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MkfaTWM2OD1zNUWuN|Qhdk1?MlHCV2FPT0WU
SBC-1M1fJeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NXTKZXRPUUN3ME2xOVYvPCCwTR?=MnTOV2FPT0WU
OVCAR-4NUCyWJBwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NYnpc4hWUUN3ME2xOVYvPzhibl2=NIrkUXdUSU6JRWK=
NCI-H2347NXHJOVNvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NF\aUWFKSzVyPUG1PE4{PCCwTR?=M1rpNnNCVkeHUh?=
CAMA-1MlLaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MVfJR|UxRTF3OT6zN{BvVQ>?M3H5TnNCVkeHUh?=
GDM-1MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NYnUR3k{UUN3ME2xOVkvPyCwTR?=M1X4e3NCVkeHUh?=
KNS-81-FDNGDWVYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NF;6d41KSzVyPUG2NE4{OiCwTR?=M2fxS3NCVkeHUh?=
no-10NGfucpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M2r6OGlEPTB;MU[wMlM5KG6PMlLJV2FPT0WU
NCI-H2052M4nDbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NFXhSpRKSzVyPUG2NE41PyCwTR?=NYPLT293W0GQR1XS
DBNWTvNW16T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NITFbVdKSzVyPUG2NU44OSCwTR?=NFvBRnJUSU6JRWK=
A4-FukNXr4O3dbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MmTHTWM2OD1zNkKuOFghdk1?NUPtXpd6W0GQR1XS
HCE-TMnnES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M2jOS2lEPTB;MU[0Mlg4KG6PNW\pSno{W0GQR1XS
HuP-T3MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MX7JR|UxRTF4NT61OUBvVQ>?M2TFNXNCVkeHUh?=
BC-3NWXY[mMxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MVjJR|UxRTF4NT64OkBvVQ>?NVLIWYt[W0GQR1XS
RVH-421NH3RSYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=Ml;TTWM2OD1zNkmuNVMhdk1?MUXTRW5ITVJ?
COLO-800M4jOS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MYDJR|UxRTF5MT64JI5OMojzV2FPT0WU
OMC-1NYrXSGNGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NVzDbW43UUN3ME2xO|IvOTdibl2=MmKxV2FPT0WU
SJRH30M{Xyd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7M1fwRWlEPTB;MUeyMlk1KG6PNX\MeGZrW0GQR1XS
HELNWH2R25UT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NX3BUYd[UUN3ME2xO|UvOTVibl2=M2PyVXNCVkeHUh?=
KLEMYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MVTJR|UxRTF5NT60O{BvVQ>?MlfMV2FPT0WU
MEG-01Mli5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NHT0OXFKSzVyPUG3Ok43KG6PMl;JV2FPT0WU
OAW-28MnzkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MWTJR|UxRTF5OD64OEBvVQ>?MkTPV2FPT0WU
RDM3jyOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MlfITWM2OD1zOECuNUBvVQ>?M2XUe3NCVkeHUh?=
HCC2218NYK4T2t[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MWXJR|UxRTF6MT62OkBvVQ>?NVG2enNXW0GQR1XS
OS-RC-2NFXoTndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NEnjVZhKSzVyPUG4Nk41QSCwTR?=MXXTRW5ITVJ?
HEC-1MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NWPrSXZnUUN3ME2xPFIvQDNibl2=MlT1V2FPT0WU
SCC-4NEDhcnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MkfYTWM2OD1zOEOuO|Ehdk1?NHvhWmVUSU6JRWK=
ME-180M2fQN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MX;JR|UxRTF6Nj6wPEBvVQ>?MXnTRW5ITVJ?
NB10MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MmSyTWM2OD1zOEiuNFkhdk1?M1P2c3NCVkeHUh?=
SCC-15NEK5SFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MYHJR|UxRTF6OD6yOEBvVQ>?M4Pq[XNCVkeHUh?=
COR-L105MoHwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M2XUfWlEPTB;MUi4MlkzKG6PMonXV2FPT0WU
HT-1376NFzhOmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MX;JR|UxRTF6OT6wNUBvVQ>?NGHaR5JUSU6JRWK=
RPMI-8866NFv2UVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MUfJR|UxRTF7Mj6xN{BvVQ>?MmXoV2FPT0WU
NCI-H2126M3HGWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MU\JR|UxRTF7Mj6yJI5OMYXTRW5ITVJ?
KARPAS-422M1vENGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MVLJR|UxRTF7Mz60NUBvVQ>?Mo[yV2FPT0WU
COLO-741M17ZXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MUHJR|UxRTF7ND61PEBvVQ>?NWjjSXNCW0GQR1XS
IPC-298NV:3dmRLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NVezWXNkUUN3ME2xPVYvOjFibl2=M1OzcXNCVkeHUh?=
OE19M{DvPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MWTJR|UxRTJyMD6xPEBvVQ>?MYjTRW5ITVJ?
NCI-H1694MnrTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NVG0T284UUN3ME2yNFAvOjZibl2=M1L6d3NCVkeHUh?=
SW1990MmT5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MkLkTWM2OD1{MEGuPUBvVQ>?NEXl[VRUSU6JRWK=
LNCaP-Clone-FGCMWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MonaTWM2OD1{MESuOFchdk1?NF60SGtUSU6JRWK=
LB831-BLCMnLxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MUPJR|UxRTJyNj6yOUBvVQ>?MXTTRW5ITVJ?
HCT-116MlTXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MYrJR|UxRTJyNz6zPUBvVQ>?NGHy[JFUSU6JRWK=
BxPC-3MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NVXJUlZiUUN3ME2yNVAvQTZibl2=MnzuV2FPT0WU
HT-1197NVHxPY5VT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MUfJR|UxRTJzMj61PEBvVQ>?M3nMPXNCVkeHUh?=
GB-1NVrtcoVCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MXvJR|UxRTJzMj63N{BvVQ>?NHzUd3BUSU6JRWK=
RPMI-8226MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M4q1NWlEPTB;MkGzMlM4KG6PNW\hW2p4W0GQR1XS
L-540MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NXqwRo5FUUN3ME2yNVMvPDlibl2=MnntV2FPT0WU
NCI-H1882NWXqb5hET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NWPqNVVpUUN3ME2yNVUhdk1?NYHn[FIzW0GQR1XS
A673MkniS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NW\uXFQzUUN3ME2yNVUvPzlibl2=M3zYdHNCVkeHUh?=
NCI-H650NGq4PWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NF;EXXVKSzVyPUKxO{43OSCwTR?=MXnTRW5ITVJ?
KM12M2S1d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NXr3N|Z5UUN3ME2yNVgvOTVibl2=NYq0dollW0GQR1XS
KP-N-YSMkH2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NHK3fYRKSzVyPUKxPE41KG6PMUnTRW5ITVJ?
COLO-684M2DMUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NYfWfoFjUUN3ME2yNVkvPzlibl2=NFHj[IRUSU6JRWK=
MHH-NB-11M3PZWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NIjNcmpKSzVyPUKyNE4zOiCwTR?=MkX5V2FPT0WU
HO-1-N-1NHjPTIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NWKyN3plUUN3ME2yNlIvQDNibl2=NVLRdmp6W0GQR1XS
NOMO-1M2\xe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MnLCTWM2OD1{MkSuOFMhdk1?MXzTRW5ITVJ?
KYSE-70NYTrVWoxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MVjJR|UxRTJ{ND62OkBvVQ>?NIPTUotUSU6JRWK=
NCI-H838NWfOU3ZZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NVfJ[oRLUUN3ME2yNlQvPzNibl2=MVrTRW5ITVJ?
NYNXLSWJpkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NULCPWt[UUN3ME2yNlgvPDlibl2=MXPTRW5ITVJ?
NCI-H2196MkSzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MXLJR|UxRTJ{OT6xOUBvVQ>?MorPV2FPT0WU
FTC-133MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NXuzcYJ5UUN3ME2yNlkvOzdibl2=MkezV2FPT0WU
MHH-PREB-1Ml6yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M2PsTGlEPTB;MkK5MlgzKG6PNYnz[|k3W0GQR1XS
SK-MEL-2Mo\6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MVHJR|UxRTJ|MD6zJI5ONYXj[JlvW0GQR1XS
Detroit562M{jqVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MWrJR|UxRTJ|MD63NkBvVQ>?MmXEV2FPT0WU
NCI-H2405NX\xbHVJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MUXJR|UxRTJ|ND6xJI5OM2jQNXNCVkeHUh?=
NCI-H2081M2D0WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M1nuTGlEPTB;MkO0MlI4KG6PMmf2V2FPT0WU
LB2241-RCCNEjPcm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NEKzUIFKSzVyPUKzOU4yOSCwTR?=NGfMVZBUSU6JRWK=
SNU-387NUHHdHAzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NGiyOVlKSzVyPUKzOk4xQCCwTR?=NF3n[ZpUSU6JRWK=
PC-14M4L6bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NWPRRo1UUUN3ME2yN|YvOTJibl2=MWPTRW5ITVJ?
CAS-1MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NXXFSlFNUUN3ME2yN|gvOzFibl2=NWHwRVdRW0GQR1XS
TE-11NXT4NlZZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NF3MUmZKSzVyPUK0NE45QCCwTR?=Ml;aV2FPT0WU
LC4-1NFq2PYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M{ftZWlEPTB;MkSwMlg6KG6PNWPL[GV4W0GQR1XS
HHNX;pcZQ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M3OwcWlEPTB;MkSxMlQ3KG6PM363RXNCVkeHUh?=
JVM-2NEDiN4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NUS5UFV1UUN3ME2yOFIvOTdibl2=MkDXV2FPT0WU
KNS-42NYr1bWs{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NULO[VlyUUN3ME2yOFIvPjdibl2=M1zGUXNCVkeHUh?=
T-24NG\ZXZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NF\wfZFKSzVyPUK0OU41QCCwTR?=NFfyTFJUSU6JRWK=
D-392MGM3PKV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MoLiTWM2OD1{NEiuOUBvVQ>?M4D6dHNCVkeHUh?=
KOSC-2NFLOOJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MlX4TWM2OD1{NEiuO|Ehdk1?M3;CO3NCVkeHUh?=
D-283MEDMXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MXzJR|UxRTJ3MD6xN{BvVQ>?MVjTRW5ITVJ?
BV-173M1PIcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NWKzPJpTUUN3ME2yOVAvPzdibl2=MVzTRW5ITVJ?
EW-18MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MkjZTWM2OD1{NUCuPUBvVQ>?MXvTRW5ITVJ?
MS-1MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MlrTTWM2OD1{NUKuOVMhdk1?NUPFdFRzW0GQR1XS
Calu-6MoT2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NU\HTIVRUUN3ME2yOVMvPTVibl2=NYTwVVFMW0GQR1XS
GR-STM{LSSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M1;PNWlEPTB;MkW1MlQzKG6PMlL5V2FPT0WU
GAKMn24S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MV3JR|UxRTJ3Nj65NUBvVQ>?NXu3Nnk6W0GQR1XS
TE-9NEC0fYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MlHBTWM2OD1{NUeuOFchdk1?NILUTGNUSU6JRWK=
HuH-7NIrMN4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=Ml7yTWM2OD1{NUiuOFQhdk1?MWrTRW5ITVJ?
KYSE-520MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NWiwbW44UUN3ME2yOlAvPzdibl2=MkfBV2FPT0WU
NCI-H520MnfrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?Mn\yTWM2OD1{Nk[uOlEhdk1?MVrTRW5ITVJ?
HD-MY-ZMUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NYjFWlhFUUN3ME2yO|IvPzlibl2=MYTTRW5ITVJ?
SW756MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NF7E[XFKSzVyPUK3OE44QCCwTR?=MY\TRW5ITVJ?
NB12MlTmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M{Ht[WlEPTB;Mke3MlEzKG6PMlPHV2FPT0WU
EW-3M2PzZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NYjIcJIyUUN3ME2yO|kvQDlibl2=MX;TRW5ITVJ?
AM-38NY\JVXVuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MoD3TWM2OD1{OEGuOVIhdk1?NWLLbFR5W0GQR1XS
NCI-H23MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NVGzNmQ5UUN3ME2yPFMvQTJibl2=NEfpSHpUSU6JRWK=
GOTOMkfaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MXfJR|UxRTJ6NT61OkBvVQ>?MYPTRW5ITVJ?
NCI-H1693NYjyPYhGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=Mk\aTWM2OD1{OUCuN|Ihdk1?NVHOc3h1W0GQR1XS
MOLT-16M3rkO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NVTVSVJTUUN3ME2yPVAvPSCwTR?=NY\vb2hyW0GQR1XS
HOP-92MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?Mn21TWM2OD1{OUCuO{BvVQ>?NXz2ZnpwW0GQR1XS
MDA-MB-361NEDBeIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M33LTWlEPTB;MkmyMlY2KG6PMV\TRW5ITVJ?
Ramos-2G6-4C10Ml7QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NWDmOXVRUUN3ME2yPVQvPTVibl2=MX3TRW5ITVJ?
CAL-54M3r3dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M2HZT2lEPTB;M{CwMlc{KG6PMl\pV2FPT0WU
D-263MGMVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?Mk\vTWM2OD1|MEWuOVIhdk1?M1mxOHNCVkeHUh?=
SKG-IIIaNELCe3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NVLDRW9GUUN3ME2zNVEvOTRibl2=M1voUHNCVkeHUh?=
HAL-01NVHsPYVQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NEG4TJlKSzVyPUOxN{41PCCwTR?=NX20dnZ[W0GQR1XS
LAN-6NWLNRnVOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M4[xZmlEPTB;M{G1MlEyKG6PMUPTRW5ITVJ?
NCI-H1304NHrJ[nhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MVrJR|UxRTN{MT6xO{BvVQ>?M1vLXXNCVkeHUh?=
no-11MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MXLJR|UxRTN{MT62OEBvVQ>?M3P4bXNCVkeHUh?=
IST-MES1M{G0[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NYjkZW5IUUN3ME2zNlMvOzVibl2=NYnJfYw5W0GQR1XS
L-363NUW0XYc6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NX;SRoFGUUN3ME2zNlQvPDNibl2=M3PXbHNCVkeHUh?=
EM-2MnHzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M{XW[WlEPTB;M{K1MlQyKG6PNWXxdW9QW0GQR1XS
DV-90M2OybGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MkTGTWM2OD1|MkmuOFUhdk1?MXTTRW5ITVJ?
Saos-2NF\4eGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MVzJR|UxRTN{OT65OEBvVQ>?NUfvWG4{W0GQR1XS
UMC-11MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MoTWTWM2OD1|M{GuNlghdk1?MkTPV2FPT0WU
RajiNX[5dJVyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MXzJR|UxRTN|ND62OEBvVQ>?MUPTRW5ITVJ?
RXF393MnLCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MU\JR|UxRTN|NT60N{BvVQ>?NV;CV4htW0GQR1XS
EW-11MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NXThTVBuUUN3ME2zOFEvPTZibl2=NVK1dYVLW0GQR1XS
BL-70NEfrVoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NF3URWxKSzVyPUO0Nk4xOSCwTR?=MVrTRW5ITVJ?
LB373-MEL-DMVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NXX2WmQ1UUN3ME2zOFQvPjRibl2=NXjoTVRyW0GQR1XS
LU-139M{m2c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7M17aT2lEPTB;M{S0MlkzKG6PM4j6NnNCVkeHUh?=
U-87-MGMVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NUXPcIw6UUN3ME2zOFYvODRibl2=M{TWOHNCVkeHUh?=
LU-65MkDIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NHy4bnlKSzVyPUO0Ok41KG6PNInMcohUSU6JRWK=
U031NUnQcWZuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MYHJR|UxRTN3Mz64O{BvVQ>?MlW5V2FPT0WU
HNM3nSV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NEP5TnNKSzVyPUO1OE4zPyCwTR?=NYnLNHd2W0GQR1XS
MHH-CAL-2NX3WPW1[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MWLJR|UxRTN3OT6yNUBvVQ>?NGrLdodUSU6JRWK=
NCI-H510AMlXDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M1jE[2lEPTB;M{W5MlU6KG6PNHHXZXBUSU6JRWK=
NB5M373eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NXrIUJBuUUN3ME2zOVkvQDFibl2=NXvMc3gxW0GQR1XS
KG-1NGWwNmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M2DVOmlEPTB;M{[xMlUzKG6PNXfIS4RXW0GQR1XS
EFO-21MnPVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MY\JR|UxRTN4MT64OUBvVQ>?MlHyV2FPT0WU
UACC-257MkLaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?Mm\tTWM2OD1|NkKuNFUhdk1?M3PERnNCVkeHUh?=
SW1417M37yUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M2jqTWlEPTB;M{[zMlI{KG6PNEmzVHVUSU6JRWK=
NCI-H1417MnX0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NYLWXHpKUUN3ME2zO|AvODRibl2=MknRV2FPT0WU
DSH1MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NXr6TlFrUUN3ME2zO|IvPzJibl2=MmLDV2FPT0WU
CAKI-1NWP5flR2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MnnpTWM2OD1|N{WuOFghdk1?M1;0d3NCVkeHUh?=
SIMANFy4ZYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NUTCWXJ3UUN3ME2zPFEvQDZibl2=M17FZXNCVkeHUh?=
LS-1034M{DZd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MmDtTWM2OD1|OESuOVEhdk1?NWS5SVhVW0GQR1XS
K-562NWi3Z4s2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MVPJR|UxRTN6NT64JI5ONXjaeFg1W0GQR1XS
LOXIMVIM1Tp[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7M1i1TWlEPTB;M{i5MlE6KG6PNFjnUWJUSU6JRWK=
MC116MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MoTLTWM2OD1|OUGuOFEhdk1?NF\hToZUSU6JRWK=
MPP-89NUG3NHA4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NXXaPIFLUUN3ME2zPVIvQTRibl2=MVrTRW5ITVJ?
SN12CMkS1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?Ml61TWM2OD1|OUSuPFchdk1?MV\TRW5ITVJ?
BHT-101NYGyZ2N3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MkC4TWM2OD1|OUWuPVIhdk1?Mo\lV2FPT0WU
DMS-114MlXRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MWfJR|UxRTN7Nj6zNUBvVQ>?NFLabVZUSU6JRWK=
NCI-H1838NUTCSGlFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M4T3RWlEPTB;NEC1MlA2KG6PNH;DOZRUSU6JRWK=
HTMW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NHL0d5RKSzVyPUSwOU4yPSCwTR?=NFvk[ZpUSU6JRWK=
Caov-3NU\EUGplT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NYHUTWFEUUN3ME20NFYvOTlibl2=NFfGbW1USU6JRWK=
LB2518-MELNVzJc4J6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=Ml;NTWM2OD12MUOuNUBvVQ>?MUXTRW5ITVJ?
C3AMoraS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M3\2O2lEPTB;NEG1Mlc6KG6PNWWwZZQ1W0GQR1XS
NCI-H226NInMXIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NVTrWVRjUUN3ME20NVYvPjRibl2=MYnTRW5ITVJ?
KMS-12-PENF24PGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MoL6TWM2OD12MUiuNFYhdk1?NYP4SmZEW0GQR1XS
RERF-LC-MSM3LMZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NF3KNW5KSzVyPUSyOU4xPSCwTR?=NVX6cVN[W0GQR1XS
OE33NWXX[|Z4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M1rQOmlEPTB;NEK2MlAzKG6PNYG0bopuW0GQR1XS
COLO-678Mn\4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?Mn;RTWM2OD12MkeuNVghdk1?NVnxXlU{W0GQR1XS
NCI-H1963MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MXTJR|UxRTR|MD6xNUBvVQ>?MlPoV2FPT0WU
LAMA-84M{TrW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NFfNeopKSzVyPUSzO{4{KG6PMW\TRW5ITVJ?
NCI-H2171MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NEOxN2pKSzVyPUS0NE43PyCwTR?=MnT6V2FPT0WU
U-266MnXBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M371TmlEPTB;NEWxMlQ6KG6PM{D3enNCVkeHUh?=
SNU-C2BNETVTllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M1nWPGlEPTB;NE[wMlk4KG6PMX3TRW5ITVJ?
T47DNXPKUHI4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M1XVTGlEPTB;NE[5MlY6KG6PMV;TRW5ITVJ?
TE-6NULPNJg{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MlHBTWM2OD12NkmuPFEhdk1?MlPmV2FPT0WU
OVCAR-3MnvIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M2T1emlEPTB;NEewMlQyKG6PNXHXc2M1W0GQR1XS
C-4-IINH7XNpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M2q1UWlEPTB;NEeyMlU3KG6PNHnhVFJUSU6JRWK=
EFM-19M4PzTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MULJR|UxRTR5OD6yO{BvVQ>?NUTjZ5RCW0GQR1XS
NCI-N87NGGxSlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NH3XWoRKSzVyPUS3PU46OiCwTR?=MmPMV2FPT0WU
NCI-H187M2[1[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MWTJR|UxRTR7Mz6yNUBvVQ>?NGjFPJdUSU6JRWK=
MDA-MB-157NHnseYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=Mki5TWM2OD12OUmuNFEhdk1?MlzuV2FPT0WU
OPM-2NHu3foRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M37qcGlEPTB;NUCxMlgyKG6PNYr5cWhvW0GQR1XS
COLO-320-HSRMoLPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NEGyWnVKSzVyPUWxN{4yPiCwTR?=MmToV2FPT0WU
RMG-IMUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M1rNXGlEPTB;NUGzMlk5KG6PM2P1NXNCVkeHUh?=
IST-SL1NGLhVXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NIKybYhKSzVyPUWxO{41OiCwTR?=MoPZV2FPT0WU
UACC-893NGjZVnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MU\JR|UxRTV{MT61NUBvVQ>?NXXkeGJPW0GQR1XS
BeckerMn\CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?Mn7lTWM2OD13MkGuPFMhdk1?NXzKXmd4W0GQR1XS
HPAF-IIM{TvUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MWDJR|UxRTV{Nz6yOEBvVQ>?MXvTRW5ITVJ?
HCC1954MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MoXsTWM2OD13NECuPFMhdk1?NWDlT2hQW0GQR1XS
SNU-449NWW5SI92T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NG\uTFRKSzVyPUW0PE4xOSCwTR?=NF;XRZVUSU6JRWK=
NCI-H1563NYPvSHVjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M4TXd2lEPTB;NUW2MlQ6KG6PMnLxV2FPT0WU
HDLM-2NWDDd5ZwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NVnne5lHUUN3ME21OlgvPTlibl2=M{LibnNCVkeHUh?=
NCI-H69NIrPSnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NGexU3hKSzVyPUW2PE45KG6PMX;TRW5ITVJ?
NCI-SNU-5NXH1[I03T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=Mo\MTWM2OD13N{CuNVUhdk1?NUHXR|JHW0GQR1XS
NCI-H1792NWnCNFluT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M{OwcmlEPTB;NUeyMlQ{KG6PNWTMems4W0GQR1XS
NCI-H2141MmL0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NIL3NpJKSzVyPUW3N{43QSCwTR?=MUDTRW5ITVJ?
KMOE-2MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MofSTWM2OD13N{[uN|Ihdk1?MUnTRW5ITVJ?
NCI-H1155NHrUdpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MlHCTWM2OD13N{muPFchdk1?NEHqOYtUSU6JRWK=
LK-2M172fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MlvHTWM2OD13OEGuNFchdk1?MXLTRW5ITVJ?
HCC1187NVTHdWdsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MVrJR|UxRTV7MT60O{BvVQ>?M3G4eXNCVkeHUh?=
EGI-1NW\TXnRYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M2LKcGlEPTB;NUm4MlI4KG6PNGPRRXFUSU6JRWK=
NCI-H1623M{X6Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7Mle2TWM2OD14MESuOkBvVQ>?MYDTRW5ITVJ?
MN-60NIfvSWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NVzKPXhiUUN3ME22NFUvOzdibl2=MoL3V2FPT0WU
JARM{LINGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MX7JR|UxRTZ{NT65OUBvVQ>?NHLTPZlUSU6JRWK=
HCC1419NWjzNmFkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NVzPXVY2UUN3ME22N|EvPzRibl2=MnziV2FPT0WU
LU-165MmPqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M4WyZ2lEPTB;NkO5MlQhdk1?NVvJU2c1W0GQR1XS
TYK-nuMVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MnHhTWM2OD14NkKuOVUhdk1?MkfCV2FPT0WU
DG-75MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NFXmZVVKSzVyPU[2OU45OyCwTR?=M3HPW3NCVkeHUh?=
PFSK-1NYG4NmM2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MoHDTWM2OD14N{iuNFghdk1?MlHIV2FPT0WU
MKN7Ml7JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MnX4TWM2OD14OEmuPVUhdk1?NF70RXZUSU6JRWK=
DMS-153NInXWlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NUTDcXlLUUN3ME22PVgvOTVibl2=NVzGSGMzW0GQR1XS
HTC-C3MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MnX3TWM2OD15MEOuPVQhdk1?MoXsV2FPT0WU
GCIYNIPKNJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MVzJR|UxRTd{NT6xNkBvVQ>?MlrmV2FPT0WU
NCI-H1092MkPVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MVfJR|UxRTd|Nz65OUBvVQ>?MX7TRW5ITVJ?
EB-3NV;T[I53T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NIjuRY9KSzVyPUe3NU4xOiCwTR?=M4rNbXNCVkeHUh?=
CAL-120MomxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NH7peWFKSzVyPUe3O{42OiCwTR?=NEnnTXhUSU6JRWK=
BT-474MkLyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NE\NeGxKSzVyPUe3PE45OSCwTR?=NXL2WI1xW0GQR1XS
L-428NXTSOWxjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MYTJR|UxRTd7MD65JI5OM1L5b3NCVkeHUh?=
Mo-TNEPhNHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M2PtNmlEPTB;OEC0MlY2KG6PMnjFV2FPT0WU
CAL-72Mo\DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MkHQTWM2OD16NECuOlchdk1?NFfYNHZUSU6JRWK=
AsPC-1M2f2Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MWjJR|UxRTh3NT6yOkBvVQ>?MYDTRW5ITVJ?
U-118-MGNIP2[|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NUHhVmZ[UUN3ME24OVYvOzRibl2=M1\T[3NCVkeHUh?=
GCTNWLReZVxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MVnJR|UxRTh4MT60PEBvVQ>?MnXGV2FPT0WU
EKVXM3focWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M3vvXWlEPTB;OEexMlg4KG6PNUexSWdJW0GQR1XS
NCI-H1755MoK4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MVnJR|UxRTh5Mz61NkBvVQ>?NXPaNIo3W0GQR1XS
Capan-2M{LOUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MXXJR|UxRTh7OD6xNUBvVQ>?NYLWd2x4W0GQR1XS
NCI-H1793MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M2\RR2lEPTB;OUCwMlg4KG6PMnTBV2FPT0WU
PLC-PRF-5M3SwSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MYTJR|UxRTlyMT6zOUBvVQ>?M3vpOXNCVkeHUh?=
M14MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NHjEcGhKSzVyPUmwOU4zPyCwTR?=M2jVUHNCVkeHUh?=
SK-MEL-24M4G5RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NYPVb4YzUUN3ME25NVQvOzVibl2=MXvTRW5ITVJ?
SK-MM-2MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NVXEOoJFUUN3ME25OFIvOyCwTR?=M2L1NXNCVkeHUh?=
PC-3M33ZTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M{\Jc2lEPTB;OUW3MlIzKG6PNFe1UmVUSU6JRWK=
EW-24NVLNVXZ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NUHUfXFOUUN3ME25O|AvPCCwTR?=NFnQZmNUSU6JRWK=
MDA-MB-175-VIIMY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MmXDTWM2OD17N{GuOVMhdk1?NV;5[nE2W0GQR1XS
NCI-H1581MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M1PMWmlEPTB;OUixMlMyKG6PMXLTRW5ITVJ?
THP-1NIfhXWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NUCzfmx7UUN3ME25PFkvPDJibl2=NFzJUHJUSU6JRWK=
NCI-H1993NYfqSpduT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M4GwRmlEPTB;MT6wNFA4PiEQvF2=NFT0SG9USU6JRWK=
DOKM2HEU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MYfJR|UxRTFwMEG3OlIh|ryPNWDkXYU5W0GQR1XS
KINGS-1NX3icYFvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MmPPTWM2OD1zLkCxPUDPxE1?NV;IephUW0GQR1XS
YTMVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NEDye4tKSzVyPUGuNFQ2PjhizszNNHHNbZRUSU6JRWK=
TGBC1TKBM1T1bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NIHQcHBKSzVyPUGuNFYxOzZizszNMX;TRW5ITVJ?
TCCSUPM4\NPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7Mm\YTWM2OD1zLkKzNFg{KM7:TR?=MXzTRW5ITVJ?
BENMlXDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M2jPUmlEPTB;MT6yN|c1OiEQvF2=Mny5V2FPT0WU
KARPAS-45NHPYV2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NYDuXYppUUN3ME2xMlI3PzZ|IN88US=>M1PYfHNCVkeHUh?=
COLO-829MmD1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NXrZfHRYUUN3ME2xMlI4PDhizszNNGXzcXlUSU6JRWK=
UACC-62NVLSWHVZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NUHib4VHUUN3ME2xMlMzOTR3IN88US=>MlTIV2FPT0WU
NCI-H446MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NVS2e5B5UUN3ME2xMlM{PzdzIN88US=>NVnRe|NVW0GQR1XS
RO82-W-1MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?Mln4TWM2OD1zLkO0N|M4KM7:TR?=MlPQV2FPT0WU
NCI-H2452MlLFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MW\JR|UxRTFwM{exNlkh|ryPNV\QWoU2W0GQR1XS
RLM{LD[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M{jqdmlEPTB;MT60NlA3PiEQvF2=M3WxTnNCVkeHUh?=
NCI-H1522MmH5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MULJR|UxRTFwNEOxOVkh|ryPMknRV2FPT0WU
TGWNHL3XnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MVPJR|UxRTFwNEW5OFIh|ryPNHzVcZhUSU6JRWK=
HT55Mlj1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NVPoWVZvUUN3ME2xMlQ4OTZ6IN88US=>M4\FRnNCVkeHUh?=
KARPAS-299Moq0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MVzJR|UxRTFwNEe4OFEh|ryPMV7TRW5ITVJ?
KY821NWj3emRJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MX3JR|UxRTFwNEm0Nlkh|ryPNIXsN2lUSU6JRWK=
MDA-MB-231NHvqTmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NEWwW29KSzVyPUGuOVMxPTVizszNMWjTRW5ITVJ?
NCI-H82NVPiXZd{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MoLwTWM2OD1zLkW3NFI3KM7:TR?=MXLTRW5ITVJ?
MDA-MB-134-VIMXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NXHBTlZGUUN3ME2xMlYyPzFzIN88US=>MmryV2FPT0WU
PANC-08-13NUHvcGRHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NEf3N|lKSzVyPUGuOlMxQDRizszNMVzTRW5ITVJ?
D-542MGMXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NG\1[|RKSzVyPUGuOlU{ODVizszNNG\LdVlUSU6JRWK=
LC-1FNUnPUIpWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MYPJR|UxRTFwNk[yNFMh|ryPNWLiXWgxW0GQR1XS
KP-N-YNMoP1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M1S2bWlEPTB;MT62OlM1OyEQvF2=NGPSSZpUSU6JRWK=
MFE-280M1z4PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MY\JR|UxRTFwNk[4NVIh|ryPNU\tXmp6W0GQR1XS
S-117M4i4cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M1zubGlEPTB;MT63NFUxPCEQvF2=MXLTRW5ITVJ?
NCI-H1573MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MlT0TWM2OD1zLkexO|M{KM7:TR?=NF\RVJlUSU6JRWK=
BT-20NETZSnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NVP4eJZIUUN3ME2xMlc1ODZ6IN88US=>M4jkR3NCVkeHUh?=
NCI-H28MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NVnoS3V6UUN3ME2xMlc1ODd6IN88US=>MmLEV2FPT0WU
CaR-1M{DNcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NXPCdVNoUUN3ME2xMlc5OzJ2IN88US=>MWfTRW5ITVJ?
LN-405MoLvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M4ewd2lEPTB;MT64NFE1OyEQvF2=MnXtV2FPT0WU
RT4MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NGXsS4lKSzVyPUGuPFQ1OTdizszNNGjqd2tUSU6JRWK=
NCI-H889NXLDU3dvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NUKyZ3NuUUN3ME2xMlk{QDh4IN88US=>NH\HeFVUSU6JRWK=
SW1463MkDaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MU\JR|UxRTFwOUW3NFEh|ryPMXLTRW5ITVJ?
SCLC-21HNY[zenFiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NITSTXlKSzVyPUKuNFA3OjRizszNNFjIdXBUSU6JRWK=
CP66-MELNEfCNW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NUDZTXpLUUN3ME2yMlAyPzZ5IN88US=>NFS5bVNUSU6JRWK=
Hs-578-TMVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MUHJR|UxRTJwMEG3PFIh|ryPMUTTRW5ITVJ?
HCC70MnzPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MkfoTWM2OD1{LkC1OFY{KM7:TR?=NF7Ve3JUSU6JRWK=
SW1088Mmf3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MWjJR|UxRTJwME[5N|Eh|ryPMUjTRW5ITVJ?
NB6Mkj0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MYfJR|UxRTJwMUi1JO69VQ>?M2HQ[HNCVkeHUh?=
KU-19-19NI[zXm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M{\ER2lEPTB;Mj6yOlkyPyEQvF2=NES3[VRUSU6JRWK=
A704M{nXOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M{KyT2lEPTB;Mj6yPVE{PSEQvF2=NYT2[FhNW0GQR1XS
EVSA-TM3Pmb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MUTJR|UxRTJwM{CwPFkh|ryPNWXwfIxJW0GQR1XS
HCT-15NFuyPIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MoDYTWM2OD1{LkO1OFY3KM7:TR?=NXXIbXhLW0GQR1XS
HuO-3N1NHXrU4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M3rHRmlEPTB;Mj6zOlU5OyEQvF2=M1LrOXNCVkeHUh?=
GMS-10NHzBTVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NYfBfJBHUUN3ME2yMlM6PzN6IN88US=>MlPBV2FPT0WU
TGBC24TKBM4HTdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MmfhTWM2OD1{LkSxOFI6KM7:TR?=MkXKV2FPT0WU
C2BBe1MnntS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NGe4RnhKSzVyPUKuOVE{OjhizszNNWToN405W0GQR1XS
SK-N-DZMkezS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MWTJR|UxRTJwNU[1PVIh|ryPMUTTRW5ITVJ?
SK-N-ASMU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M3zT[2lEPTB;Mj63N|AyPSEQvF2=MVLTRW5ITVJ?
T98GMnGyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MmDzTWM2OD1{LkiwOFAyKM7:TR?=MnTnV2FPT0WU
DMS-79M2TlTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NInhenJKSzVyPUKuPVA6QDhizszNNVH5clZkW0GQR1XS
SNU-475NYW0ZXFyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NWjyfWRRUUN3ME2yMlkzPTd{IN88US=>M1XoPHNCVkeHUh?=
COLO-792MlvtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M2e0SGlEPTB;Mz6wNlg4KM7:TR?=M3nWUnNCVkeHUh?=
YAPCMYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M4HiTWlEPTB;Mz6zNlg{OiEQvF2=NWrhZZh1W0GQR1XS
UACC-812MoXNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?Mmn0TWM2OD1|LkOzO|M5KM7:TR?=MnvVV2FPT0WU
MewoMWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M4rpNGlEPTB;Mz60OlA5PiEQvF2=Mk\3V2FPT0WU
COLO-824M{TKeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M{fyVGlEPTB;Mz61O|M4QCEQvF2=NFvZT5pUSU6JRWK=
SCC-9NIX6Wo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M3j0Z2lEPTB;Mz65NVMxQSEQvF2=NUi4eHR7W0GQR1XS
CP50-MEL-BNV\lVYtXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M3O2RWlEPTB;Mz65PFcxOyEQvF2=NIrMU4lUSU6JRWK=
NCI-H345NXzsNG5pT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MXzJR|UxRTRwMEGxO|Qh|ryPMUHTRW5ITVJ?
COR-L88NHjXRlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=Mke3TWM2OD12LkO5OVgh|ryPMnf4V2FPT0WU
RCM-1Ml;zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NEny[WZKSzVyPUSuOFkzPzJizszNM1ntZXNCVkeHUh?=
JVM-3M3zVbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NUjucpBDUUN3ME20MlYxPjF6IN88US=>NHvYZZNUSU6JRWK=
ECC4MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MoPmTWM2OD12Lke2OVQyKM7:TR?=NHzndVlUSU6JRWK=
MDA-MB-453NWHrd|dHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M3O5N2lEPTB;ND64OVE{PCEQvF2=NVvWO21FW0GQR1XS
SK-N-FINF:z[JFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MoHPTWM2OD13LkKyPFc4KM7:TR?=NG\0WJBUSU6JRWK=
D-502MGNEHzbnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MWjJR|UxRTVwMkSyOlIh|ryPNXHQZpdLW0GQR1XS
NCI-H2227MlnLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NH3JVYJKSzVyPUWuN|YzOzFizszNM4TiPHNCVkeHUh?=
DMS-53MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M3LwRmlEPTB;Nj6xO|ExPiEQvF2=NEHvSGFUSU6JRWK=
LB771-HNCM1G0Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NFj3[GdKSzVyPU[uOFY5ODZizszNM2Hm[nNCVkeHUh?=
BB49-HNCMV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MYrJR|UxRTdwNEG3PVEh|ryPMnq1V2FPT0WU
MDA-MB-415MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M2PvTWlEPTB;Nz61O|MxOyEQvF2=MXjTRW5ITVJ?
TALL-1NVLVSHdnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=Ml\3TWM2OD15Lkm2PFgh|ryPMlLrV2FPT0WU
HCC1395M3q2O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NILjXFRKSzVyPUiuNVUyOjJizszNNXjXNWJJW0GQR1XS
EFE-184NYPQTFhnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MmjVTWM2OD16LkO3NlE3KM7:TR?=NGrLT4dUSU6JRWK=
EC-GI-10MlH3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MUnJR|UxRThwNki2PFYh|ryPNULJXoNNW0GQR1XS
TTNEDjNmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NYT4SFJmUUN3ME25MlA3QTZ4IN88US=>NHzCeINUSU6JRWK=
U-2-OSM3XSS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NVe4clhvUUN3ME25MlgyOzl|IN88US=>MWHTRW5ITVJ?
SHP-77MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NH7rZldKSzVyPUmuPVAzQSEQvF2=M4n0TnNCVkeHUh?=
HCC1143MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MmfmTWM2OD1zMD60O|k4KM7:TR?=MULTRW5ITVJ?
A498NV3CUFA6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NXPqOW1UUUN3ME2xPE4zQTd4IN88US=>NUHJTXRsW0GQR1XS
LS-513M3XjeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NV73NmdbUUN3ME2xPE43ODl|IN88US=>NGC0U3VUSU6JRWK=
K052MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NFLoeWNKSzVyPUKxMlQ1OThizszNNWfJPJdzW0GQR1XS
SiHaMV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NXHiUXNwUUN3ME2yN{4{OzdzIN88US=>NXHhWWtMW0GQR1XS
RCC10RGBMW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NHHydoxKSzVyPUOwMlA3OTFizszNNUnkUoJbW0GQR1XS
NCI-SNU-16MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NEP6W4pKSzVyPUOxMlE5OzZizszNM17icXNCVkeHUh?=
SNU-C1M1LJR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7M4LoTmlEPTB;M{KuOFE4PSEQvF2=MkT6V2FPT0WU
C32MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NGPhRXFKSzVyPUOyMlg4OiEQvF2=NFjDRXlUSU6JRWK=
SW684M{TUbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NELXfYpKSzVyPUO0MlE2PjFizszNNFn1NlhUSU6JRWK=
SK-MEL-28M17a[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M1z0Z2lEPTB;M{WuOVM4PyEQvF2=MkL0V2FPT0WU
SK-MEL-1M3j1Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MmHETWM2OD1|Nj63OVQ4KM7:TR?=MVnTRW5ITVJ?
NCI-H720M1LZO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7M3XkR2lEPTB;NEGuPVczPiEQvF2=NYDy[ZhNW0GQR1XS
P31-FUJMXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M2rFXWlEPTB;NESuN|I5PCEQvF2=M{nMc3NCVkeHUh?=
NCI-H524M4TCVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NHXTPIVKSzVyPUS4MlgzPDhizszNMVPTRW5ITVJ?

... Click to View More Cell Line Experimental Data

In vivo In vivo, Doxorubicin in combination with adenoviral MnSOD (AdMnSOD) plus 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) has the greatest effect in decreasing the volumes of MB231 tumors and prolonging survival of mice. [1] Although its use is limited by the chronic and acute toxic side effects it produces, Doxorubicin is essential in treating breast and oesophageal carcinomas, solid tumours in childhood, osteosarcomas, Kaposi's sarcoma, soft tissue sarcomas, and Hodgkin and non-Hodgkin lymphomas. [2]
Features

Protocol(Only for Reference)

Animal Study: [1]

Animal Models Female athymic nude mice injected s.c. with MB231 cells
Formulation Dissolved in DMSO, and diluted in saline
Dosages 3 mg/kg/day
Administration Delivered intratumorly

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDog
Weight (kg)0.020.151.80.40.0810
Body Surface Area (m2)0.0070.0250.150.050.020.5
Km factor36128520
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

References

[1] Sun W, et al. Cancer Res, 2009, 69(10), 4294-4300.

[2] Granados-Principal S, et al. Food Chem Toxicol, 2010, 48(6), 1425-1438.

view more

Clinical Trial Information( data from http://clinicaltrials.gov, updated on 2016-07-30)

NCT Number Recruitment Conditions Sponsor
/Collaborators
Start Date Phases
NCT02839707 Not yet recruiting Fallopian Tube Clear Cell Adenocarcinoma|Fallopian Tube Endometrioid Adenocarcinoma|High Grade Fallopian Tube Serous Adenocarcinoma|High Grade Ovar  ...more Fallopian Tube Clear Cell Adenocarcinoma|Fallopian Tube Endometrioid Adenocarcinoma|High Grade Fallopian Tube Serous Adenocarcinoma|High Grade Ovarian Serous Adenocarcinoma|Ovarian Clear Cell Adenocarcinoma|Ovarian Endometrioid Adenocarcinoma|Ovarian Seromucinous Carcinoma|Primary Peritoneal High Grade Serous Adenocarcinoma|Recurrent Fallopian Tube Carcinoma|Recurrent Ovarian Carcinoma|Recurrent Primary Peritoneal Carcinoma|Undifferentiated Fallopian Tube Carcinoma|Undifferentiated Ovarian Carcinoma National Cancer Institute (NCI) May 2017 Phase 2|Phase 3
NCT02743065 Not yet recruiting Hepatocellular Carcinoma Fifth Affiliated Hospital, Sun Yat-Sen University|Third A  ...more Fifth Affiliated Hospital, Sun Yat-Sen University|Third Affiliated Hospital, Sun Yat-Sen University September 2016 --
NCT01775475 Not yet recruiting AIDS-related Diffuse Large Cell Lymphoma|AIDS-related Diffuse Mixed Cell Lymphoma|AIDS-related Diffuse Small Cleaved Cell Lymphoma|AIDS-related Imm  ...more AIDS-related Diffuse Large Cell Lymphoma|AIDS-related Diffuse Mixed Cell Lymphoma|AIDS-related Diffuse Small Cleaved Cell Lymphoma|AIDS-related Immunoblastic Large Cell Lymphoma|AIDS-related Lymphoblastic Lymphoma|AIDS-related Peripheral/Systemic Lymphoma|AIDS-related Small Noncleaved Cell Lymphoma|Stage III AIDS-related Lymphoma|Stage IV AIDS-related Lymphoma AIDS Malignancy Consortium|National Cancer Institute (NCI  ...more AIDS Malignancy Consortium|National Cancer Institute (NCI)|The EMMES Corporation September 2016 Phase 2
NCT02783599 Not yet recruiting Soft Tissue Sarcoma Eli Lilly and Company September 2016 Phase 1
NCT02685657 Not yet recruiting Triple Negative Breast Cancer Russian Academy of Medical Sciences|Russian Society of Cl  ...more Russian Academy of Medical Sciences|Russian Society of Clinical Oncology September 2016 Phase 2

view more

Chemical Information

Download Doxorubicin (Adriamycin) SDF
Molecular Weight (MW) 579.98
Formula

C27H29NO11.HCl

CAS No. 25316-40-9
Storage 3 years -20℃powder
6 months-80℃in solvent
Synonyms NSC 123127
Solubility (25°C) * In vitro DMSO 100 mg/mL warming (172.41 mM)
Water 20 mg/mL (34.48 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Name (8S,10S)-10-((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyl-tetrahydro-2H-pyran-2-yloxy)-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione hydrochloride

Frequently Asked Questions

  • Question 1
    Why the IC50 of the compound varied over time in our measurement?

    Answer: Sometimes the IC50 value might vary between different batch of compounds due to the slight differences in purity. If different IC50 was seen in the same batch of compound, the problem may lies in the process of dissolvement. Make sure that you see no particles and the solution is clear with your stock solution.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

* Indicates a Required Field

Related Topoisomerase Products

  • SCR7

    SCR7 is a specific DNA Ligase IV inhibitor, which blocks nonhomologous end-joining (NHEJ).

  • Blasticidin S HCl

    Blasticidin S HCl is a nucleoside antibiotic isolated from Stretomyces girseochromogenes, and acts as a DNA and protein synthesis inhibitor, used to select transfected cells carrying bsr or BSD resistance genes.

  • LMK-235

    LMK-235 is a selective inhibitor of HDAC4 and HDAC5 with IC50 of 11.9 nM and 4.2 nM, respectively.

  • Etoposide

    Etoposide is a semisynthetic derivative of podophyllotoxin, which inhibits DNA synthesis via topoisomerase II inhibition activity.

  • Irinotecan

    Irinotecan is a topoisomerase I inhibitor for LoVo cells and HT-29 cells with IC50 of 15.8 μM and 5.17 μM, respectively.

    Features:Irinotecan is a prodrug that is used to treat metastatic colorectal cancer.

  • Camptothecin

    Camptothecin is a specific inhibitor of DNA topoisomerase I (Topo I) with IC50 of 0.68 μM in a cell-free assay. Phase 2.

  • Daunorubicin HCl

    Daunorubicin HCl inhibits both DNA and RNA synthesis and inhibits DNA synthesis with Ki of 0.02 μM in a cell-free assay.

  • SN-38

    SN-38 is an active metabolite of CPT-11, inhibits DNA topoisomerase I, DNA synthesis and causes frequent DNA single-strand breaks.

  • Topotecan HCl

    Topotecan HCl is a topoisomerase I inhibitor for MCF-7 Luc cells and DU-145 Luc cells with IC50 of 13 nM and 2 nM in cell-free assays, respectively.

    Features:Topotecan is a water-soluble derivative of camptothecin.

  • Idarubicin HCl

    Idarubicin HCl is a hydrochloride salt form of Idarubicin which is an anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells with IC50 of 3.3 ng/mL in a cell-free assay.

    Features:Idarubicin is a substrate for CYP450 2D6 and 2C9.

Recently Viewed Items

Tags: buy Doxorubicin (Adriamycin) | Doxorubicin (Adriamycin) ic50 | Doxorubicin (Adriamycin) price | Doxorubicin (Adriamycin) cost | Doxorubicin (Adriamycin) solubility dmso | Doxorubicin (Adriamycin) purchase | Doxorubicin (Adriamycin) manufacturer | Doxorubicin (Adriamycin) research buy | Doxorubicin (Adriamycin) order | Doxorubicin (Adriamycin) mouse | Doxorubicin (Adriamycin) chemical structure | Doxorubicin (Adriamycin) mw | Doxorubicin (Adriamycin) molecular weight | Doxorubicin (Adriamycin) datasheet | Doxorubicin (Adriamycin) supplier | Doxorubicin (Adriamycin) in vitro | Doxorubicin (Adriamycin) cell line | Doxorubicin (Adriamycin) concentration | Doxorubicin (Adriamycin) nmr
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Contact Us