Doxorubicin (Adriamycin) Licensed by Pfizer

Catalog No.S1208

Doxorubicin (Adriamycin) is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis in tumor cells.

Price Stock Quantity  
USD 117 In stock
USD 90 In stock
USD 210 In stock
USD 670 In stock
Bulk Inquiry

Massive Discount Available

Free Overnight Delivery on all orders over $ 500.

Doxorubicin (Adriamycin) Chemical Structure

Doxorubicin (Adriamycin) Chemical Structure
Molecular Weight: 579.98

Validation & Quality Control

6 customer reviews :

Quality Control & MSDS

Related Compound Libraries

Product Information

  • Compare Topoisomerase Inhibitors
    Compare Topoisomerase Products
  • Research Area
  • Combination Therapy
    Combination Therapy

Product Description

Biological Activity

Description Doxorubicin (Adriamycin) is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis in tumor cells.
Targets Topo II [1]
(Tumor cells)
In vitro Doxorubicin, an antibiotic anthracycline, is commonly considered to exert its anti-tumor activity at two fundamental levels, altering DNA and producing free radicals to trigger apoptosis of cancer cells through DNA damage. Doxorubicin can block the synthesis of DNA by intercalating into the DNA strand, and inhibits DNA topoisomerase II (TOP2). Doxorubicin is most effective when cells are rapidly proliferating and expressing high levels of TOP2. Additionally, Doxorubicin can trigger apoptosis by producing ceramide (which prompts apoptosis by activating p53 or other downstream pathways such as JNK), the degradation of Akt by serine threonine proteases, the mitochondrial release of cytochrome c, increased FasL (death receptor Fas/CD95 ligand) mRNA production, and a greater production of free radicals. [2] Pre-treatment with GSNO (nitrosoglutathione) suppresses the resistance in the doxorubicin-resistant breast cancer cell line MCF7/Dx, accompanied by enhanced protein glutathionylation and accumulation of doxorubicin in the nucleus. [3] Doxorubicin induced G2/M checkpoint arrest are attributed to elevated cyclin G2 (CycG2) expression and phospho-modification of proteins in the ataxia telangiectasia mutated (ATM) and ATM and Rad3-related (ATR) signaling pathways. [5] Doxorubicin inhibits AMP-activated protein kinase (AMPK), resulting in SIRT1 dysfunction, p53 accumulation, and increased cell death in mouse embryonic fibroblasts (MEFs) and cardiomyocytes, which can be further sensitized by pre-inhibition of AMPK. [6] Doxorubicin elicits a marked heat shock response, and that either inhibition or silencing of heat shock proteins enhance the Doxorubicin apoptotic effect in neuroblastoma cells. Nanomolar Doxorubicin treatment of neuroblastoma cells causes dose-dependent over-ubiquitination of a specific set of proteins in the absence of measurable inhibition of proteasome, and loss of activity of ubiquitinated enzymes such as lactate dehydrogenase and α-enolase, the protein ubiquination patterns of which is similar to those with proteasome inhibitor Bortezomib, indicating that Doxorubicin may also exert its effect by damaging proteins. [8]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
L1210MVPGeY5kfGmxbjDBd5NigQ>?MY\Jcohq[mm2aX;uJI9nKFKQQTDzfY51cGW|aYOge4l1cCCHREWwJI9nKDBwNUig{txOM4W0cFQ6ODV|Nh?=
Yoshida sarcomaM4TlcGZ2dmO2aX;uJGF{e2G7M4CwfWlvcGmkaYTpc44hd2ZiW{PIYXRlWiCrbnPvdpBwemG2aX;uJJdqfGhiSVO1NEBw\iByLkCyJO69VQ>?NG\YWWMyOzJ{OUi2
CHOMYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M1T5TWlEPTB;MD6wOkDPxE1?MWexN|U1PzVy
8226NHjDNFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MVTJR|UxRTBwMEOzJO69VQ>?NWLEUoZoOTR2N{ezNC=>
8226/ADRMVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NWKyRnQxUUN3ME2wMlU3KM7:TR?=NFewengyPDR5N{Ow
MCF7/ADRM2H4fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7Mk\ITWM2OD1|LkGg{txONGXxVWQyPDR5N{Ow
H69MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MlTHTWM2OD1yLki3JO69VQ>?MmW0NVQ4QTV6NR?=
N417MoDYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M{PJbWlEPTB;MD6yN{DPxE1?NGfvfmQyPDd7NUi1
H9M3XnTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NYHjXoN6UW6qaXLpeIlwdiCxZjDIPUBk\WyuczDjbJJwdmmlYXzsfUBqdm[nY4Tl[EB4cXSqIITo[UBJUVZvMTCoTFkwUUmLQjmge4l1cCCLREWwJI9nKDBwMEGg{txOMYKxOVQ5Pjhz
T-C8166MlPXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MWPJSFUxRTBwMEGg{txOMmi2NVU1QDZ6MR?=
T-H9NF70Z25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MWDJSFUxRTBwMEGg{txONXrXTFdJOTV2OE[4NS=>
T-MT4MlnQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MUDJSFUxRTBwMEGg{txOMUGxOVQ5Pjhz
SKMEL-5NULsRZZ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MUTFSFUxRTNwMjFOwG0>NYDxeXkyOTZzM{e1Ny=>
MLMMUjDfZRwfG:6aXOgRZN{[Xl?NIr6S|dGTDVyPUCuNVMh|ryPMlXLNVg4PTN3MB?=
KBM-3M{n2VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MoTETWM2OD1yLkCyOkDPxE1?MX:xPVk2QDd5
HT-29M2rIZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NV7xdGFiOC5yMTFOwIc>NFuwZ3Y1QCCqMUjBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eR?=MnTsNlc4QDR2OR?=
EMT6NWrWSG5kT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=Mk\VNE42KM7:TR?=NWLLO2NZOSCqNFnx[|dKdmirYnn0bY9vKG:oIIDyc4xq\mW{YYTpc44h[nlibXXhd5VzcW6pIH\vdkB{fXK4aY\pcoch\nKjY4Tpc45{KHerdHigSWQ2OCCxZjCwMlAxODFizszNM3\1clc1PTJ4N{S=
H2981NF\GWnhEgXSxdH;4bYMhSXO|YYm=M1rPU2lEPTB;MD61JO69VQ>?MoKzO|c{OTB{Mx?=
LOXNH7aeHZEgXSxdH;4bYMhSXO|YYm=M2frXWlEPTB;MD6wOFIh|ryPNV\LemFCPzh3M{OzNS=>
C38MXjDfZRwfG:6aXOgRZN{[Xl?M2PhNWlEPTB;MD6wNUDPxE1?NV7GOnZEQDB3N{K5NS=>
EACM13semN6fG:2b4jpZ{BCe3OjeR?=M1v6eVczKGh?MmTvTWM2OD1yLkO1JO69VQ>?NF\i[XU5OzVyMEi3
SKVLBMmTqR5l1d3SxeHnjJGF{e2G7M3[4dmlEPTB;NT62JO69VQ>?MknhPFU4PjlzNB?=
AUC375NEjxOYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MkHVTWM2OD1yLkGxNkDPxE1?NVTi[Zd5QDZ2OE[wNC=>
A2780-C25MmKxR5l1d3SxeHnjJGF{e2G7NXr1RmdjS3m2b4TvfIlkcXS7IHHnZYlve3Rib4jhcIlxdGG2aX6tdoV{cXO2YX70JGEzPzhyLVOyOUB4cXSqIFnDOVAhd2ZiMD6wOlMh|ryPMmTtPFg{OTd3NR?=
A2780-CP3NVn5SVJqS3m2b4TvfIlkKEG|c3H5NXnKZXljS3m2b4TvfIlkcXS7IHHnZYlve3RiY3nzdIxifGmwLYLld4l{fGGwdDDBNlc5OC2FUEOge4l1cCCLQ{WwJI9nKDBwMEW2JO69VQ>?M1PxVVg5OzF5NUW=
A2780-DX5MVjDfZRwfG:6aXOgRZN{[Xl?MoPKR5l1d3SxeHnjbZR6KGGpYXnud5Qh\G:6b4L1ZolkcW5vcnXzbZN1[W62IFGyO|gxNUS[NTD3bZRpKEmFNUCgc4YhOC5|NUeg{txOM{\pZVg5OzF5NUW=
MXF7Mn\zR5l1d3SxeHnjJGF{e2G7NXjFU3BESW62aYT1cY9zKGGldHn2bZR6KGGpYXnud5Qhe2Wwc3n0bZZmKE2[Rkege4l1cCCLQ{WwJI9nKDBwMEK4JO69VQ>?NFLYeFc5QTZyNUW4
MXF7NV;oXIpIS3m2b4TvfIlkKEG|c3H5NGPzfo1CdnSrdIXtc5Ih[WO2aY\peJkh[WejaX7zeEBucXSxeHHueJJwdmVvcnXzbZN1[W62IF3YSlchf2m2aDDJR|UxKG:oIECuNFI5KM7:TR?=M{j5cFg6PjB3NUi=
MXF7NWTpOYZRS3m2b4TvfIlkKEG|c3H5Mk\IRY51cXS3bX;yJIFkfGm4aYT5JIFo[Wmwc4Sg[I95d3K3YnnjbY4uemW|aYP0ZY51KE2[Rkege4l1cCCLQ{WwJI9nKDFwMUeyJO69VQ>?NX;oSYRMQDl4MEW1PC=>
WiDrMkPqR5l1d3SxeHnjJGF{e2G7M{CyOmFkfGm4aYT5JIFo[Wmwc4Sgd4Vve2m2aY\lJHdqTHJiY3XscEB4cXSqIFnDOVAhd2ZiMD6wOVMh|ryPNIe4[405QTZyNUW4
MCFNVzIVoVwTnWwY4Tpc44hSXO|YYm=MUnS[ZZmenOjbDDv[kBRNWeyLX3l[IlifGWmIH31cJRq\HK3ZzDy[ZNqe3SjbnPlJIF{e2W|c3XkJIF{KGWwaHHuZ4Vu\W62IHnuJIN6fG:2b4jpZ4l1gSCxZjDh[JJq[W27Y3nuM1n6ZVg6QDRzNUG=
C6MYLDfZRwfG:6aXOgRZN{[Xl?MoLmNk42KG2pL33MMk\EO|IhcA>?NYDENIM3TE2VTx?=NHzFdYNEgXSxdH;4bYNqfHliYXfhbY5{fCC{YYSgR|Yh[2WubIOgZZQhPTBidXevcWwhfG9iMj61JI1oN22ONVnHe2ZiQDl6OE[wOC=>
C6NF23e3hHfW6ldHnvckBCe3OjeR?=NEL2emkzNjVibXevcWw>NWWzTZdNPCCqNHnUT5hFVVORNXH4OWo2UW6qaXLpeIlwdiCxZjD0eYJ2dGmwIIDvcJlu\XKrenH0bY9vM2jCU|g6QDh4MES=
C6MVPDfZRwfG:6aXOgRZN{[Xl?NVvWPHB3Oi53IH3nM41NNIHpOYs2KGh?NUjJNo1{TE2VTx?=M3vvfmN6fG:2b4jpZ4l1gSCjc4Pld5Nm\CCjczDj[YxtKHKnbHXhd4U>MnXMPFk5QDZyNB?=
SKVLBM1;uR2N6fG:2b4jpZ{BCe3OjeR?=MVi3NkBpNEnz[lFKSzVyPU[uOVQh|ryPNYPtdGoxQTByM{WyNC=>
MCF7/VP16MlfkR5l1d3SxeHnjJGF{e2G7NV;QSnhWPTBizsznM41NNE\LSWI4OiCqMX7JR|UxRTF2LkKg{txOMlr4PVAzOjd7Mh?=
CA755M{f3[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NHzqTI0yOCEQvF2=MmS4OkBlM2TLT2lEPTB;MD6wNVQh|ryPNWT1TVhTQTV{NkW3NC=>
CHOM2jt[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NFnTO2cyOCEQvF2=NVX1bZZGPiCmMWHJR|UxRTBwME[g{txOM3fQT|k2OjZ3N{C=
Panc02NVPiflQ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M3XNelExKM7:TR?=NVfmZ4c1PiCmMXzJR|UxRTBwME[1JO69VQ>?M3L3b|k2OjZ3N{C=
PC14MlSyR5l1d3SxeHnjJGF{e2G7Mn\QOEBlM4LLdGROW09?MoHvTWM2OD1yLkK5JO69VQ>?MYW5PFIzPTR{
HOP62NF;UWY1EgXSxdH;4bYMhSXO|YYm=MkPlO|IhcA>?M3LUbGlEPTB;MD6wNFQh|ryPNEfoU3g6QDd|Nk[x
SF-295NGTtNZREgXSxdH;4bYMhSXO|YYm=M1HNSFczKGh?NX\aZotVUUN3ME2wMlA{PSEQvF2=NHjGOm46QDd|Nk[x
MDA-MB-361NXnDNWlOS3m2b4TvfIlkKEG|c3H5NVHWfFIxOSCqNFLNfXhFVVORMX3DfZRwfG:6aXPpeJkh[WejaX7zeEBOTEFvTVKtN|YyKGW6cILld5NqdmdiTHHjXkB4cXSqIFnDOVAhd2ZiMD6wNVIh|ryPNIjRTlAyODN7NUS5NC=>
MDA-MB-361MYfDfZRwfG:6aXOgRZN{[Xl?NXPaVGljOSCqMUTEUXNQM1y4cWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KE2GQTDNRkA{PjFiZYjwdoV{e2mwZzDjZZJjd3i7cHXweIll[XOnIIP0R3BIOiC5aYToJGlEPTBib3[gNE4xOThizszNM4TCd|ExOzl3NEmw
CCRF-SBM4nyXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MU[0JIQ>NVLFblVOTE2VTx?=MkT2TWM2OD1yLkCxJO69VQ>?MmrUNVA1OTF2N{[=
CHO-K1M4jiXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NUm4dWFqPCCmM1yyZmROW09?NU\4TZlKUUN3ME2wMlQh|ryPNU[ycWZ{OTB2MUG0O|Y>
KBNEX4b3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=Mnn2OEBlM3\SbWROW09?NHPBNIVCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIRzfWdvcnXzbZN1[W62IFvCO2Qhf2m2aDDJR|UxKG:oIECuOlUh|ryPNYHK[W9KOTB2MUG0O|Y>
KBNHPvW2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M4LlN|Qh\A>?Mn3YSG1UVw>?MWrBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHTyeYcuemW|aYP0ZY51KEuEQ3HtdJdqfGhiSVO1NEBw\iByLkC2JO69VQ>?MWKxNFQyOTR5Nh?=
KBNX3mbllRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MlfaOEBlMlzlSG1UVw>?NWfWSohHSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBlenWpLYLld4l{fGGwdDDLRm1FWiC5aYToJGlEPTBib3[gNE42KM7:TR?=NH[5OGoyODRzMUS3Oi=>
KBMnTGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MVi0JIQ>NInmellFVVORM{DKbGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4Sg[JJ2\y2{ZYPpd5RidnRiS1LWNlBEKHerdHigTWM2OCCxZjCwMlQh|ryPMmrsNVA1OTF2N{[=
HTB-54MVHDfZRwfG:6aXOgRZN{[Xl?MWWxNFAh|ryPM1nOfWlEPTB;MT6xJO69VQ>?MXSxNFQ4Pjh4MR?=
MEL-ACNVLzeGI6S3m2b4TvfIlkKEG|c3H5NHOxV3oyODBizszNNV\PXI9TUUN3ME2xMlIh|ryPM1\LNFExPDd4OE[x
DU145M4H3UmN6fG:2b4jpZ{BCe3OjeR?=MU[3NkBpMUXJR|UxRTBwMEWyPEDPxE1?MofmNVA1Pzl{OEK=
K562RMnzIR5l1d3SxeHnjJGF{e2G7NIHKcW44OiCqMoHDTWM2OD1yLkCxOVYh|ryPNX\EdoFWOTB2N{myPFI>
PACA-2M3;3WGN6fG:2b4jpZ{BCe3OjeR?=MofIOkBlNWrKZWliTUR3ME2wMlAxPjNizszNNIjRcW8yODR7OEKxOC=>
3Y1M3\aXmN6fG:2b4jpZ{BCe3OjeR?=NFroR3I4OiCqMVTHTVUxRTBwMECzPEDPxE1?MXqxNFY6OTdzMB?=
P388M1nENWN6fG:2b4jpZ{BCe3OjeR?=M3vJ[VczKGh?MVTHTVUxRTBwMEGyJO69VQ>?MlXONVA3QTF5MUC=
HMV-1NI\ucFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MofCTWM2OD1yLkK4JO69VQ>?M{e3blExPjl6NEO2
MKN-1NV[4UYp3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M37aZWlEPTB;MD62OEDPxE1?M1\s[lExPjl6NEO2
PC14MkLWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NIP3WFFKSzVyPUGuPUDPxE1?M{j6O|ExPjl6NEO2
T24MmfJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M1jhRmlEPTB;MD62OEDPxE1?NWLveIxuOTB4OUi0N|Y>
U937Moe3SpVv[3Srb36gRZN{[Xl?NVvxXVdxOjRiaB?=NWrIOYI4TE2VTx?=MljVTY5pcWKrdIOgbY5kd3Kyb4LheIlwdiCxZjDbN2hefGi7bXnkbY5mKHerdHigTWM2OCCxZjCwMlEh|ryPMnHhNVA4QDB7MUG=
H460pv8/etoMVrDfZRwfG:6aXOgRZN{[Xl?Mn;3NVAxKM7:TR?=Mn\tOFghcA>?NWHCN3g1W2GuaX7lM4Cwc2lEPTB;MD6wNkDPxE1?MUGxNFc5ODlzMx?=
H460pv8NXW0U2xyS3m2b4TvfIlkKEG|c3H5MYGxNFAh|ryPM1TIS|Q5KGh?MormV4FtcW6nMUfJR|UxRTBwMEC0JO69VQ>?MV:xNFc5ODlzMx?=
MDA-231NEfBU41EgXSxdH;4bYMhSXO|YYm=M4D6V|ExOCEQvF2=NVjjXW9UPDhiaB?=MUTTZYxqdmV?MoroR5l1d3SxeHnjbZR6KGGpYXnud5QhVUSDLUKzNUBk\WyuIDjFVk0tTUeIUjuscZV1[W62IIC1N{khf2m2aDDJR|UxKG:oIECuNFA3KM7:TR?=NYPmbZhkOTB5OEC5NVM>
MDA-468MlraR5l1d3SxeHnjJGF{e2G7NVjFTXplOTByIN88US=>M2TXZVQ5KGh?MonjV4FtcW6nM321c2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KE2GQT20Olgh[2WubDCoSXIuNCCjbYDsbYZq\WRiRVfGVkwhdXW2YX70JJA2Oylid3n0bEBKSzVyIH;mJFAvODB3IN88US=>NUTnU2VvOTB5OEC5NVM>
NCI-H226M1zrdGN6fG:2b4jpZ{BCe3OjeR?=M1rhTlExOCEQvF2=NUjUTFVFPDhiaB?=MYDTZYxqdmV?M1vXSWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KE6FST3INlI3KGOnbHygLI12fGGwdDDwOVMqKHerdHigTWM2OCCxZjCwMlAxQCEQvF2=NX\0c5ZYOTB5OEC5NVM>
NCI-H322MlzWR5l1d3SxeHnjJGF{e2G7MXyxNFAh|ryPNFHJSGY1QCCqM{L2fnNidGmwZR?=NYLDTIdJS3m2b4TvfIlkcXS7IHHnZYlve3RiTlPJMWg{OjJiY3XscEApdXW2YX70JJA2Oylid3n0bEBKSzVyIH;mJFAvODNizszNMkjZNVA4QDB7MUO=
NCI-H358MmXWR5l1d3SxeHnjJGF{e2G7MmXpNVAxKM7:TR?=NVv0N25jPDhiaB?=MlzIV4FtcW6nMXHDfZRwfG:6aXPpeJkh[WejaX7zeEBPS0lvSEO1PEBk\WyuIDjteZRidnRicEWzLUB4cXSqIFnDOVAhd2ZiMD6xN{DPxE1?NEK4eJIyODd6MEmxNy=>
NCI-H647MmfoR5l1d3SxeHnjJGF{e2G7M3;OXFExOCEQvF2=MX[0PEBpM4O1fHNidGmwZR?=NX3GPWZbS3m2b4TvfIlkcXS7IHHnZYlve3RiTlPJMWg3PDdiY3XscEApdXW2YX70JJA2Oylid3n0bEBKSzVyIH;mJFAvODBzIN88US=>MnG3NVA4QDB7MUO=
SKBR-3MornR5l1d3SxeHnjJGF{e2G7NE\zdXgyODBizszNMlLOOFghcA>?MVzTZYxqdmV?NX:5[Zl1S3m2b4TvfIlkcXS7IHHnZYlve3RiU1vCVk0{KGOnbHygLGVTNWGvcHzp[olm\CCnclKyMI12fGGwdDDwOVMqKHerdHigTWM2OCCxZjCwMlAzKM7:TR?=NEjXN4cyODd6MEmxNy=>
T47DM2jBTGN6fG:2b4jpZ{BCe3OjeR?=MlXhNVAxKM7:TR?=MnryOFghcA>?NGjGflRU[WyrbnW=NWnuPGhyS3m2b4TvfIlkcXS7IHHnZYlve3RiVES3SEBk\WyuIDjFVkstdXW2YX70JJA2Oylid3n0bEBKSzVyIH;mJFAvODB5IN88US=>M3vlRlExPzhyOUGz
ZR-75-1NF\FdWhEgXSxdH;4bYMhSXO|YYm=NU\XSG9SOTByIN88US=>NEjONIo1QCCqNEjXfnZU[WyrbnW=MlnDR5l1d3SxeHnjbZR6KGGpYXnud5QhYlJvN{WtNUBk\WyuIDjFVksteGe{KzzteZRidnRicEWzLUB4cXSqIFnDOVAhd2ZiMD6wNFkh|ryPMnnzNVA4QDB7MUO=
L1210M3rneWN6fG:2b4jpZ{BCe3OjeR?=NYX2UYtwUUN3ME2wMlAzPSEQvF2=Mmm2NVA5QTBzNke=
D40NH7LVGxEgXSxdH;4bYMhSXO|YYm=MUWyOEBpM{PvXmROW09?NEW2WY1KSzVyPUGuNVczKM7:TR?=M1Xm[|ExQTV4MkG0
OVCAR-3M3TneGN6fG:2b4jpZ{BCe3OjeR?=NFvocY4zPCCqMXvEUXNQNF:zT4VKSzVyPUCuNFM2KM7:TR?=MYOxNFk2PjJzNB?=
UA375NFzhZXhEgXSxdH;4bYMhSXO|YYm=Mnv1NlQhcA>?NV\Cc4VHTE2VTx?=NF7hfYhKSzVyPUCuNVEzKM7:TR?=MYixNFk2PjJzNB?=
CH1M4TBOmN6fG:2b4jpZ{BCe3OjeR?=NVrnW2x5QTZiaB?=MW\EUXNQNGDFdXZKSzVyPUCuNFA3OyEQvF2=NXP6WG55OTFzMkO5PFk>
RENCAMYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?Mlu2OFghcA>?M3fJd2lEPTB:MD6wNUDPxE1?MV2xNVQ2PDR4Nx?=
CNSMk\jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MmrZOFghcA>?NUj4ZXY3T0l3ME2wMlA3PCEQvF2=NFu3fJAyOTR5M{SxPC=>
J82MkjBR5l1d3SxeHnjJGF{e2G7NX\nc3lIOTBizszNMYLEUXNQNH;6cZFEgXSxdH;4bYNqfHliYXfhbY5{fCCMOEKgd4Vve2m2aY\lJINmdGxid3n0bEBKSzVyIH;mJFAvODNizszNMVWxNVYxPjF2MR?=
LoVoM1\OVGN6fG:2b4jpZ{BCe3OjeR?=MlG3NVAh|ryPNGG0XXBFVVORMYjDfZRwfG:6aXPpeJkh[WejaX7zeEBNd1[xIIPlcpNqfGm4ZTDj[YxtKHerdHigTWM2OCCxZjCwMlAxQCEQvF2=MXuxNVYxPjF2MR?=
T24NWrKeGFtS3m2b4TvfIlkKEG|c3H5NWrpeIJyOTBizszNMoWwSG1UVw>?NXi4bIhbS3m2b4TvfIlkcXS7IHHnZYlve3RiVEK0JJNmdnOrdHn2[UBk\WyuIIfpeIghUUN3MDDv[kAxNjB{IN88US=>MUSxNVYxPjF2MR?=
U373MWnDfZRwfG:6aXOgRZN{[Xl?M3;JdlExKM7:TR?=M3rlWGROW09?M3nyfmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KFV|N{Ogd4Vve2m2aY\lJINmdGxid3n0bEBKSzVyIH;mJFAvODFizszNMoroNVE3ODZzNEG=
U87MWDDfZRwfG:6aXOgRZN{[Xl?Ml3ZNVAh|ryPNEK3eYpFVVORNH72ZVBEgXSxdH;4bYNqfHliYXfhbY5{fCCXOEegd4Vve2m2aY\lJINmdGxid3n0bEBKSzVyIH;mJFAvODZizszNM2C1XFEyPjB4MUSx
U87NIm0SpFEgXSxdH;4bYMhSXO|YYm=MlXTNVAh|ryPMkTVSG1UVw>?M2fONGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KFV6NzDy[ZNqe3SjboSgZ4VtdCC5aYToJGlEPTBib3[gNE4yPCEQvF2=M2SybVEyPjB4MUSx
UACC62MlvXR5l1d3SxeHnjJGF{e2G7MVOzMVUhdQ>?MmLiSG1UVw>?M1fDRmdKPTB;MD6wPVQh|ryPMXOxNVY4QDZ2OR?=
SKVLB1MYnDfZRwfG:6aXOgRZN{[Xl?MkDmO|IhcA>?NYTzUVFXTE2VTx?=M4W2WWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJI12dHSrZIL1[{1z\XOrc4ThcpQhW0uYTFKxJINmdGxid3n0bEBKSzVyIH;mJFIvOiEQvF2=MmW1NVE4PTR4MEK=
HCT116MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MlXsS2k2OD1yLkCyN{DPxE1?MX[xNVc2PTN4Mx?=
COR-L23NGXsWW5EgXSxdH;4bYMhSXO|YYm=MmfsOU03KGR?M1nadWlEPTB;MD6wNlAyKM7:TR?=M2TqcVEyQDB4N{K0
H69PNV7MNW9nS3m2b4TvfIlkKEG|c3H5NYH6OZI4PS14IHS=MnTPTWM2OD1yLkCyO|Mh|ryPM1vVfFEyQDB4N{K0
H69/LX4MkG1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MX60JIQ>NF;nPHNKdmirYnn0c5J6KGGldHn2bZR6KGGpYXnud5Qh\HK3ZzDy[ZNqe3SjboSgTFY6N0y[NDDj[YxtKG:4ZYLlfJBz\XO|aX7nJHAu\2y7Y3;wdo91\WmwIIfpeIghUUN3MDDv[kAxNjF|NzFOwG0>Mn3yNVE5ODZ5MkW=
H69PM1y2ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M2\KblQh\A>?NEmwOmVKSzVyPUCuNFI4KM7:TR?=M4DHT|EyQDB4N{K1
U251NYqwRldpS3m2b4TvfIlkKEG|c3H5NUHjUGV7UUN3ME2wMlA6KM7:TR?=MVGxNlA{QTV6OB?=
UMUC3M3vveGN6fG:2b4jpZ{BCe3OjeR?=NEn1TmFKSzVyPUCuNFA6OiEQvF2=NXzSe|Y3OTJ|OUK3Nlc>
CRL7065MlLoR5l1d3SxeHnjJGF{e2G7NEfLSJQ3KGR?NELiW25FVVORNGq4eWpKSzVyPUCuOUDPxE1?NID3e2gyOjR|MUC0PC=>
SKMEL-28MWTDfZRwfG:6aXOgRZN{[Xl?M{DN[FYh\A>?NWSzXHV1TE2VTx?=NYnpbmZoUUN3ME2wMlA3KM7:TR?=Moi4NVI1OzFyNEi=
SK-MES-1MnXDR5l1d3SxeHnjJGF{e2G7NH\qOXY3KGR?MkPQSG1UVw>?NGnoe|NKSzVyPUCuNFMh|ryPNIj1bnUyOjR|MUC0PC=>
Hep-2M3;KNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MoDiPVYhcA>?Mm\DSG1UVw>?M2S4TGlEPTB;MD6wOEDPxE1?NFHUSFcyOjR|MUC0PS=>
RajiNX3ZZYRCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MlnUPVYhcA>?MVfEUXNQMUfJR|UxRTBwMEOg{txOMkTUNVI1OzFyNEm=
Wil-NSNEnuVJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=Mn:xPVYhcA>?M4fqbmROW09?M1vifWlEPTB;MD6wNkDPxE1?MW[xNlQ{OTB2OR?=
2SC/20NHz5d5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NIfTcXg4OiCqM37jR4RmcW:waYrl[EB4[XSnch?=NYrtflBZUUN3ME2wMlYzKM7:TR?=MkfuNVI1OzFyNkC=
HET-SR-2SC-LNMMlLwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NG\iNnU4OiCqNX;2c2lC\GWrb37pfoVlKHejdHXyMnfPTWM2OD1yLkC1NkDPxE1?M1TP[lEzPDNzME[w
L1210MVvDfZRwfG:6aXOgRZN{[Xl?NGfETJY1QCCqMlfzSG1UVw>?NUfJNlFFUUN3ME2wMlAzPSEQvF2=NW\mbYFnOTJ2NEO3OlM>
LXFL529M4\xUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MX2zOkBpNHmwNZFKSzVyPUCuNFQh|ryPMVKxNlQ2QTB{MB?=
8226/DOX1VNUjubVlYS3m2b4TvfIlkKEG|c3H5NX7HelZWPzJiaB?=NEnOSpZFVVORNXv3UJVIS3m2b4TvfIl1gSCjZ3HpcpN1KDh{Mk[vSG9ZOVZ?MlXjNVI2PzB|N{i=
8226/SNWnJOpJQS3m2b4TvfIlkKEG|c3H5NF\v[oo4OiCqMmDaSG1UVw>?MXXDfZRwfG:6aYT5JIFo[Wmwc4SgPFIzPi:VNEjtfZQyOjV5MEO3PC=>
JurkatNX2zWmoxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NYPzPXE3PzJiaB?=Mm\1TWM2OD1yLkCwPVYh|ryPNHLjR3kyOjZ{MEC4NS=>
P388MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NFTXUZo4OiCqM36wVmlEPTB;MD6wNVUh|ryPMoXFNVI3OjByOEG=
L2987M1LXR2N6fG:2b4jpZ{BCe3OjeR?=NFr2ZmpKSzVyPUCuN{DPxE1?NFf1e|MyOjd7OEOxOy=>
401NLMXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MUK3NkBpMnHqSG1UVw>?MlTUTWM2OD1yLkCxJO69VQ>?MnPxNVI5PTJ5Nki=
LXF529LMX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MofsO|IhcA>?MUHEUXNQMYfJR|UxRTBwMEOg{txOMn;MNVI5PTJ5Nki=
LXF629LMXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NFnvVmc4OiCqMlHoSG1UVw>?NGTlZW9KSzVyPUCuNFch|ryPNUXibmNZOTJ6NUK3Olg>
RXF944LMU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NFywTHY4OiCqM2DXZmROW09?NE\VUoVKSzVyPUCuNFYh|ryPM{XRTlEzQDV{N{[4
Neuro2ANIfvdGxHfW6ldHnvckBCe3OjeR?=NWK5NoY{OyC3Zz;tUC=>M13YeVI1KGh?NX;ZV3k6VmW3cnn0c4dmdmmlIHHjeIl3cXS7IHHzd4V{e2WmIHHzJI1wenCqb3zv[4lk[WxiY3jhcodmew>?NWKxZYJuOTR3N{W0OFA>
HT1080MmrVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MVu3NkBpNGXle4tFVVORMUPJR|UxRTBwMEW5JO69VQ>?MYCxOFY1ODVzMx?=
H460M2C0OWN6fG:2b4jpZ{BCe3OjeR?=NU\RXHl{T0l3ME2zMlDjiIoFl,MAjVExNTdizsznM41NNXGydHI3OTR4NEC1N|I>
MCF7MnryR5l1d3SxeHnjJGF{e2G7MnX6S2k2OD16LkFihKnEn+LCiUGwMVch|rypL33MMofWNVQ3PDB3M{K=
SF268NVjKdWJ6S3m2b4TvfIlkKEG|c3H5NY\PbFhnT0l3ME24MlXjiIoFl,MAjVExNTdizsznM41NM{DwV|E1PjRyNUOy
DuPRONHHiT|REgXSxdH;4bYMhSXO|YYm=NVnkWVZITUN3ME2xMlgh|ryPMX:xOFY3PzJyOB?=
DU145NHnHcZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M4HBb|czKGh?NXvBV5JWTE2VTx?=MnO5S2k2OD1yLkCyJO69VQ>?M4PhdFE1QTdzOEmz
HeLaM3Tuc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7M3n0NlczKGh?NITscW9FVVORNGXRSXVIUTVyPUCuNFEh|ryPNYf1W41bOTR7N{G4PVM>
IGROVMWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NXLv[mh6PzJiaB?=NYDxUXRSTE2VTx?=M{O2PGdKPTB;ND60JO69VQ>?MUmxOFk4OTh7Mx?=
LNcaPNYK0dHp7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MofOO|IhcA>?MXLEUXNQNG\iU4JIUTVyPUCuNFIh|ryPMkDZNVQ6PzF6OUO=
LOVOM{C0S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NX\QNIpmPzJiaB?=NXXMPHQ1TE2VTx?=M4rIcGdKPTB;MD6wNUDPxE1?NXTKUGVIOTR7N{G4PVM>
MEL-28MkTTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NUexe4NJPzJiaB?=MUPEUXNQM1PMfmdKPTB;Mz6xJO69VQ>?M4DOZ|E1QTdzOEmz
PANC-1NFPNOoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NV24dXBtPzJiaB?=NV\WTmpnTE2VTx?=NHv6[ZRIUTVyPUOuOUDPxE1?NInRXGIyPDl5MUi5Ny=>
MDA-MB-435NIXPcHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MmfZOEBpNGXxUoZFVVORNGTkUYZKSzVyPUCuNVUh|ryPMUKxOFk4OTh7OR?=
TRAMP-C2DMmPWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NITFNFU4OiCqNW\q[mU4UUN3ME2wMlA1PjVizszNNH60UXcyPDl5MUmxNC=>
TRAMP-C2GMmTaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MVe3NkBpMYjJR|UxRTBwMEK4O{DPxE1?NFfFd|MyPDl5MUmxNC=>
MD-MB468MVzDfZRwfG:6aXOgRZN{[Xl?NWnnZpYyPzJiaB?=NGjqV2NKSzVyPUCuNFA4KM7:TR?=Mm\WNVQ6QDB4N{K=
T47DNELGR2lEgXSxdH;4bYMhSXO|YYm=M{fkc|czKGh?NXu3U3F7UUN3ME2wMlAxPyEQvF2=NFXpeXgyPDl6ME[3Ni=>
RPMI8226MnzTR5l1d3SxeHnjJGF{e2G7MUK3NkBpNUP6XFc3UUN3ME2wMlEh|ryPNXPJfGNzOTR7OEewOFk>
U937/GTBNILld29EgXSxdH;4bYMhSXO|YYm=NXXkN5lKPzJiaB?=NVvhSoh7UUN3ME2wMlEh|ryPMUKxOFk5PzB2OR?=
Col2NHrZR2ZEgXSxdH;4bYMhSXO|YYm=MXi3NkBpM{[0SWROW09?NV3rOY5ZUUN3ME2wMlUzKM7:TR?=M3ryWVE2OTd5NEO4
MEL-28NYTCWo9nS3m2b4TvfIlkKEG|c3H5MYLJR|UxRTBwMEOg{txONUn3[5h4OTV{MkW3NFA>
Rtx6MonyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NWH6TYx5PCCqMoPpSG1UVw>?MnXqS5Jwf3SqIHnubIljcXSrb36gc4YhTVJiZYjwdoV{e2mwZzDSeJg3KGOnbHzzNFfyTnYyPTV6OEC4Oi=>
WI38M1PCdGN6fG:2b4jpZ{BCe3OjeR?=Ml\zOFghcA>?M{XUNGROW09?NXXrUWQ{UUN3ME2wMlMh|ryPMofqNVU3OjB{M{i=
MeVoNIPROXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NVzzTnVMOjRiaB?=MVj3ZZRmeg>?MVfJR|UxRTBwOEKg{txONVXEOolQOTV5MUW0PFE>
VA13NI\PfItEgXSxdH;4bYMhSXO|YYm=NGfRSpI1QCCqNVf0RpdpTE2VTx?=NIrycppKSzVyPUCuN|gh|ryPM1y2N|E2PzNyMkSz
NCI-H69NXXz[IVzS3m2b4TvfIlkKEG|c3H5MoT1OkBlNXz0cHRkUUN3ME2wMlAyOTNizszNNYTifJR{OTV5NEOxO|g>
HSC-2MVHDfZRwfG:6aXOgRZN{[Xl?NYPEWIxbOjRiaB?=NWGxZppVS0N3ME2wMlY5KM7:TR?=M3vkcFE2PzR3OEGy
HSGNYLLNGhsS3m2b4TvfIlkKEG|c3H5NILtTGIzPCCqMUXDR|UxRTFwOTFOwG0>MV:xOVc1PThzMh?=
MES-SAMYfDfZRwfG:6aXOgRZN{[Xl?NWr0bplzUUN3ME2wMlAyPiEQvF2=Mn\XNVYyPjl5MUm=
MESSA/DX5NWDCRlJFS3m2b4TvfIlkKEG|c3H5MYLDfZRwfG:6aXPpeJkh[WejaX7zeEBufWy2aXTyeYcuemW|aYP0ZY51KE2HUz3TRU9FgDViY3XscJMhf2m2aDDJR|UxKG:oIEGuOVYh|ryPMlnKNVYyPjl5MUm=
VA13NXzYOHgzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NFL2dpc1QCCqMkPPSG1UVw>?NYHs[2kyUUN3ME2wMlIzKM7:TR?=MW[xOlQ6QTN{Mh?=
MCF7M3qzXmZ2dmO2aX;uJGF{e2G7NYPyWI5ZOC53IN88[{9uVA>?MnLTNlQhcA>?NHPmTmVFVVORMYjJcohq[mm2aX;uJI9nKHB3Mz3t[YRq[XSnZDD0doFve2GldHn2ZZRqd25?NWW3T4ZrOTZ6NkKxOFE>
5637MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NH7iRlg6PiCqMmjhSG1UVw>?NIjBOFRKSzVyPUCuNFIh|ryPNFXaWnkyPjlzM{ewNC=>
ACHNM3T0cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NHT5cnk6PiCqMl7HSG1UVw>?NH7hWnBKSzVyPUCuNFAyKM7:TR?=MnnjNVY6OTN5MEC=
C8166MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MkXqPVYhcA>?MnXPSG1UVw>?M{\FPWlEPTB;MD6wNkDPxE1?MVSxOlkyOzdyMB?=
G361MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NHu1Ong6PiCqNULNSpNwTE2VTx?=NGLBcZZKSzVyPUCuNFkh|ryPNVfDUoZbOTZ7MUO3NFA>
Wil2-NSMVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NFTWeJA6PiCqMkTySG1UVw>?NFrzbYFKSzVyPUCuNFIh|ryPNF3LWVkyPjlzM{ewNC=>
BCNFPXT|lEgXSxdH;4bYMhSXO|YYm=NWLSfXoxUUN3ME2wMlI5QCEQvF2=NVjWNVU2OTZ7M{O4PVA>
HL60/ADRNEfId5VEgXSxdH;4bYMhSXO|YYm=M{TMTlEhdU1?NEn6PJA4OiCqMV7EUXNQMmfER5l1d3SxeHnjbZR6KGGpYXnud5Qh[WS{aXHtfYNqdi2{ZYPpd5RidnRiSFy2NE9CTFJiY3XscJMh\XiycnXzd4lv\yCPUmCxJJdqfGhiSVO1NEBw\iB{IN88US=>NEDHT2MyPzB4OUmzOC=>
HA22TM{\ZeGN6fG:2b4jpZ{BCe3OjeR?=MlWzO|IhcA>?M3rwXmROW09?MlfJTWM2OD1yLkOxJO69VQ>?MmLlNVcyODd6ME[=
AGSMYLDfZRwfG:6aXOgRZN{[Xl?NVHLb5NTUUN3ME2wMlMyKM7:TR?=MWKxO|EzPTJ2MB?=
H9c2MmDHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NXPHZmk1OjRiaB?=MnG2SG1UVw>?MlXoTWM2OD1yLkCxPVk2KM7:TR?=M3rPUFE4OTJ3MkWz
SHP77M1XyR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7Mo\aNlQhcA>?MWLEUXNQMlLZTWM2OD1yLkGyOVg6KM7:TR?=MWmxO|EzPTJ3Mx?=
SK-HEP-1MoW1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MX6yOEBpMWPEUXNQMlHiTWM2OD1yLkC1NFEzKM7:TR?=M1zJ[VE4OTJ3MkWz
VeroMorKR5l1d3SxeHnjJGF{e2G7NXv2N|QyOjRiaB?=M1q5c2ROW09?MofETWM2OD1yLkWwNVE6KM7:TR?=M{DqfFE4OTJ3MkWz
A2780M2PRN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MmLwNUDPxE1?M{XtelQh\A>?M4fUc2ROW09?NIj0WYpKdmirYnn0bY9vKG:oIHPpd5Bt[XSrbj3y[ZNqe3SjboSgRVI4QDBiY3XscEBoem:5dHige4l1cCCLQ{WwJI9nKDBwMECzJO69VQ>?MVqxO|EzPTJ3NB?=
A2780MkCxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MojTNUDPxE1?NH21ZYY1KGR?NXqze5gyTE2VTx?=MVXJcohq[mm2aX;uJI9nKGSxeH;yeYJq[2mwLYLld4l{fGGwdDDBNlc5OCClZXzsJIdzd3e2aDD3bZRpKEmFNUCgc4YhOC5yNkGg{txOMUGxO|EzPTJ3NB?=
MDA-MB-231NXPyS|N[S3m2b4TvfIlkKEG|c3H5NUfDPYdjPzJiaB?=M3fINWROW09?MkLiTWM2OD1yLkCzJO69VQ>?MnP4NVcyPDF7MkO=
MDA435/LCC6M1vsVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NUS1cll6PCCmMV;EUXNQNWm3fZVHUUN3ME2wMlMh|ryPNFvoeJMyPzF3NEWwOS=>
K562NUW2eHpbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NVizWnFTPDhiaB?=MVnEUXNQN22ndHjhco9tNV7LSnFvUUN3ME2wMlAyKM7:TR?=NEHqc5EyPzF6MUG2OC=>
TRAMP-C1AMnixS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M1nFdFczKGh?NVvVfXJ[f2G2ZYK=NHf6U4tIUTVyPUCuNFIxPCEQvF2=MnXSNVcyQDFzNk[=
TRAMP-C2HNGXoOlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MU[3NkBpMnXHe4F1\XJ?Mn\NS2k2OD1yLkCxOVgh|ryPM2HQXVE4OThzMU[2
2780ADNU\mTm1CS3m2b4TvfIlkKEG|c3H5NEHDbHcyOCEQvF2=MkLJR5l1d3SxeHnjbZR6KGGpYXnueEBufWy2aXTyeYcuemW|aYP0ZY51KGi3bXHuJFI4QDCDRDDj[YxteyC5aYToJGlEPTBib3[gNE46ODlizszNMoLENVczOzl3OUe=
K562I/S9M1q3[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MYS3NkBpM4PlS2ROW09?M{nBcGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5ibYXseIllenWpLYLld4l{fGGwdDDLOVYzcS:VOTDj[YxteyCneIDy[ZN{cW6pIGDndEB4cXSqIFnDOVAhd2ZiMjFOwG0>MUmxO|I4PjZ7MB?=
CEM/VLB100MXfDfZRwfG:6aXOgRZN{[Xl?NELwRVA4OiCqM{K1R2ROW09?MoL1R5l1d3SxeHnjbZR6KGGpYXnud5QhfmmwYnzhd5RqdmVvcnXzbZN1[W62IFPFUU9XVEJzMECgZ4VtdHNid3n0bEBKSzVyIH;mJFMvPzFizszNMWOxO|MzOzl|OR?=
CEM/VM1M4HlZ2N6fG:2b4jpZ{BCe3OjeR?=M4LVbVczKGh?M2rTWGROW09?M2TJN2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KHSnbnnwc5Nq\GVvcnXzbZN1[W62IFPFUU9XVTFiY3XscJMhf2m2aDDJR|UxKG:oIECuOVUh|ryPM4XNe|E4OzJ|OUO5
MeVoMWDDfZRwfG:6aXOgRZN{[Xl?NVrRdmh1PDhiaB?=MoDYe4F1\XJ?NYHX[odGUUN3ME2wMlgzKM7:TR?=MWOxO|M4PTlyMh?=
KB-VINMn\ZR5l1d3SxeHnjJGF{e2G7M2O0W|czKGh?M1[xWmROW09?NIDzVplEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBufWy2aXTyeYcuemW|aYP0ZY51KEuELW\JUkBk\WyuczD3bZRpKEWFNUCgc4YhOS55IN88US=>NIm1TJoyPzN5OEWzNC=>
2780ADM2\DPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MXyxNEDPxE1?MUfHdo94fGhiaX7obYJqfGmxbjDv[kBufWy2aXTyeYcuemW|aYP0ZY51KGi3bXHuJFI4QDCDRDDj[YxteyC5aYToJGlEPTBib3[gNE4zQThizszNMlfKNVc1QTB6N{i=
BGC823NITlZllEgXSxdH;4bYMhSXO|YYm=NGPUNWY1QCCqMVPJR|UxRTBwM{Wg{txOMXuxO|U5Ozl3Mx?=
ZR-751Mn;3R5l1d3SxeHnjJGF{e2G7Mn3XO|IhcA>?MmjTSG1UVw>?NHO0bGVKSzVyPUCuNFQh|ryPMmS4NVc2QDV5NEe=
1A9MmPiR5l1d3SxeHnjJGF{e2G7MoWxSG1UVw>?MoPNSWQ2OD1yLkCyJO69VQ>?MlrhNVc2QTF2NES=
LNcaPMlTqR5l1d3SxeHnjJGF{e2G7NHjRTG1FVVORNEjUOFhGTDVyPUCuNFQh|ryPNUnBWYhUOTd3OUG0OFQ>
UACC62MlW3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MlrTOFghcA>?NYXFTGtMTE2VTx?=MWnHTVUxRTBwMEm0JO69VQ>?NUjQS|VyOTd4MUSyPVI>
DLD1NG[4TIpEgXSxdH;4bYMhSXO|YYm=NWPsOHNHPzJiaB?=NGXScHhKSzVyPUCuNUDPxE1?MXGxO|Y2PjB7MR?=
UO31M2W1[WN6fG:2b4jpZ{BCe3OjeR?=M4fsPFczKGh?MXHJR|UxRTBwMTFOwG0>MXOxO|Y2PjB7MR?=
PC3MWjGeY5kfGmxbjDBd5NigQ>?Mnr4NlAhdk1?M1\pNFczKGh?M{XLZ2lv\HWldHnvckBw\iC|ZX7ld4NmdmOnIHnuJIh2dWGwIGDDN{Bk\Wyucx?=M4LxNlE4PjV6N{e3
BxPc3M1T6W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NVX2WYVlOyCqMli5TWM2OD1yLkOxOlI{KM7:TR?=MnHkNVc3QTZ3MU[=
IGROVINEXGXFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M4LSTlQ5KGh?MUXJR|UxRTBwMUC5OlUh|ryPNHnMRnMyPzZ7NkWxOi=>
RXF393NF\aS2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NEi4S|I1QCCqMWLJR|UxRTBwMUe3PFMh|ryPNWXmSmdCOTd4OU[1NVY>
UACC257M2rJOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MlzMOFghcA>?MXHJR|UxRTBwMkC4PVMh|ryPM1zrTVE4Pjl4NUG2
MIAPaCa2MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NXzrPJp2OTByIN88US=>MkXJO|IhcA>?NH\TUnZKSzVyPUCuNFI1KM7:TR?=NXnaNI5ROTd7M{WzNFk>
WI38Ml3rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NF\mbW4yODBizszNNUXHeG1qPzJiaB?=NVn1boVQUUN3ME2wMlEh|ryPM3;TOFE4QTN3M{C5
KB3.1NEXaUFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MoTXNVAxKM7:TR?=NYr1[lR2PzJiaB?=Ml3KSG1UVw>?NFf2V4FKSzVyPUCuNFAxPCEQvF2=MWGxO|k1QTh3OR?=
MCF7NWfDdYhPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=Ml\VNVAxKM7:TR?=M1LEdlczKGh?M2XBUGROW09?MWXJR|UxRTBwMECwO{DPxE1?M{nt[lE4QTR7OEW5
2780.9SMkK3R5l1d3SxeHnjJGF{e2G7MmXjNVAxKM7:TR?=M33sU|k3KGh?MnnSR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gNlc5OC57UzDj[YxteyC3bnTldkBl\WWvIHzp[4h1KHerdHigTWM2OCCxZjCxOUDPxE1?NH\sfmYyPzl7M{K3OS=>
DaudiM2PD[mN6fG:2b4jpZ{BCe3OjeR?=NH\h[WcyODBizszNNFfOUFA6PiCqNWr0bZhHS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hTGG3ZHmgZ4VtdHNidX7k[ZIh\GWnbTDsbYdpfCC5aYToJGlEPTBib3[gNE4{KM7:TR?=Mm\2NVc6QTN{N{W=
W301MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MmP1OVAhdU1?MX20PEBpNELGZoVFVVORM{n2[Wdzd3e2aDDpcohq[mm2aX;uJI9nKFOjY3PoZZJwdXmlZYOgZ4Vz\X[rc3nh[UBYOzBzIIfpeIghUUN3MDDv[kAyOCEQvF2=MlH1NVgxPDByNEO=
SF268NXT6U282T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=Mli1O|IhcA>?Mnz2SG1UVw>?NF6xPGNKSzVyPUCuNFQh|ryPNI\CcpMyQDB3MkOyOi=>
SNU638MnLOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?Mn3MO|IhcA>?NFXiR5ZKSzVyPUCuNFch|ryPNXezS|NROThyNkOzOlY>
U373MGNGjhfGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MViyOEBpNV3NUmk5TE2VTx?=NWKyN|NvT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hXTN5M13HJINmdGy|IHPvcpRicW6rbnegWVM4O0mURWOgdIxie22rZDD3bZRpKEmFNUCgc4YhOC5zNUi0PUDPxE1?MWixPFE4OzJ|Mx?=
U373MGM{nUUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NWHh[HFtOjRiaB?=M3\LRmROW09?MVrHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDVN|c{VUdiY3XscJMh[2:wdHHpcolv\yCXaFPFNUBmgHC{ZYPzbY5oKHCuYYPtbYQhf2m2aDDJR|UxKG:oIECuNVU5PDlizszNMYGxPFE4OzJ|Mx?=
U373MGNWf4PYI2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MWmyOEBpMlXxSG1UVw>?MUXHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDVN|c{VUdiY3XscJMh[2:wdHHpcolv\yCXaHnDSUBmgHC{ZYPzbY5oKHCuYYPtbYQhf2m2aDDJR|UxKG:oIECuNVk6PTNizszNM4LCWFE5OTd|MkOz
HepG2NUfjTJVQS3m2b4TvfIlkKEG|c3H5NUH4ZWRkOTByIN88US=>NUnm[I1IPzJiaB?=NVniRms4UUN3ME2wMlA4KM7:TR?=NXfBVo83OThzOEG1O|U>
SJSA1M1rKOGN6fG:2b4jpZ{BCe3OjeR?=NV6yeZJKOSEQvF2=MnnTOkBpNGLzUFlEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBUUlODMTDj[YxteyCneIDy[ZN{cW6pIFfSVFc5KHerdHigTWM2OCCxZjCwMlAxPjJizszNM{fJNFE5OjR|Nkm2
PC3MNV\hSIVZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MWS3NkBpMX3EUXNQMorzTWM2OD1zLkGxJO69VQ>?NFnBZYIyQDJ2N{W3Ny=>
K/VP.5NYi1VnJ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M{nlblczKGh?M1LuemROW09?NUDZfo04T3Kxd4ToJIlvcGmkaYTpc44hd2ZiZYTvdI9{cWSnLYLld4l{fGGwdDDoeY1idiCNL2\QMlUh[2WubIOge4l1cCCLQ{WwJI9nKDBwNEGg{txONWPRNXVIOTh{NUi0OFI>
A375NEHleVZEgXSxdH;4bYMhSXO|YYm=M2\qPVI1KGh?MXTEUXNQMXXJR|UxRTBwMEGg{txOMmDWNVgzQDFzMkW=
Hep2M13TSmN6fG:2b4jpZ{BCe3OjeR?=MVyyOEBpMYHEUXNQM3HwRmlEPTB;MD60NkDPxE1?NHTKSFUyQDJ6MUGyOS=>
HT1080NVTxeWNTS3m2b4TvfIlkKEG|c3H5MX63NkBpMn\vSG1UVw>?M33BbmlEPTB;MD6wNlIh|ryPNUjFNZB{OTh|MkG3NVU>
SNU638M4TPR2N6fG:2b4jpZ{BCe3OjeR?=NFnnR4w4OiCqMnnFSG1UVw>?MoDNTWM2OD1yLkC1NkDPxE1?M17IVFE5OzJzN{G1
Caco2MYfGeY5kfGmxbjDBd5NigQ>?M{XabVUxKG6PNWjMO4g3PDhiaB?=M1X2S5difGW{MX\E[YNz\WG|ZTDpckBkgWOuaX6gRUBmgHC{ZYPzbY9vNGLZO48yQDR{OU[xNC=>
MCF7/DXMkLpR5l1d3SxeHnjJGF{e2G7M1P6W|I1KGh?NV3jfVlqf2G2ZYK=MVzDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDkc5hwenWkaXPpck1z\XOrc4ThcpQhVUOINz;EfEBk\WyuczD3bZRpKEmFNUCgc4YhPS5|IN88US=>M3WyTVE5PDJ7NkGw
Colon 26-L5NIj0NFBEgXSxdH;4bYMhSXO|YYm=NGLHN4E4OiCqMYrEUXNQNWPsToYzUUN3ME2wMlAyKM7:TR?=MX6xPFQ1ODJ|Mx?=
LLCNEjYdVVEgXSxdH;4bYMhSXO|YYm=MUO3NkBpMn2zSG1UVw>?MlHPTWM2OD1yLkCxJO69VQ>?MVGxPFQ1ODJ|Mx?=
L1210NIq2XXRHfW6ldHnvckBCe3OjeR?=MU[wMlUh|rypL33MNFHW[VAyOiCqM1SxZZdifGW{MVXD[YxtKGO7Y3zlJIFzemW|dDDpckBud3W|ZTDMNVIyOCClZXzsd{BjgSCjY3P1cZVt[XSrb36gZZQhTzJxTTDwbIF{\Q>?NVjF[nBQOTh3MEiyO|M>
SK-MEL-2M3XFbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M1j3cVczKGh?M3TvUmdKPTB;MD6xNUDPxE1?MmeyNVg2QDVyM{W=
AW13516NEfNSWFEgXSxdH;4bYMhSXO|YYm=Mn7YNVAxKM7:TR?=MY[0PEBpM4DGZ2dKPTB;MD6xJO69VQ>?MYCxPFY2Pzl5OR?=
AW8507NFu3enREgXSxdH;4bYMhSXO|YYm=MofaNVAxKM7:TR?=NYn0VldIPDhiaB?=MofFS2k2OD1yLkG3JO69VQ>?Mo\CNVg3PTd7N{m=
JurkatMmLaR5l1d3SxeHnjJGF{e2G7MVK3NkBpNHm1VmpKSzVyPUCuNFMh|ryPM2rGb|E5Pzh|OUWw
MRC5MmjQR5l1d3SxeHnjJGF{e2G7NIPYPXM4OiCqMlfFTWM2OD1yLkGg{txONXXJWXVWOTh5OEO5OVA>
DU145MV\DfZRwfG:6aXOgRZN{[Xl?NEnVRZAzPSEQvHevcWw>NVzNTVRrPzJiaB?=MVTJR|UxRTBwMECzPUDPxE1?NH60e|IyQDh{OUOxOi=>
Bel7402NGP0eWtEgXSxdH;4bYMhSXO|YYm=MnLtO|IhcA>?Mom5SG1UVw>?NXfSZ4E2UUN3ME2wMlAzOSEQvF2=M4fUNlE6ODJ6NEK1
HT-29MnnvR5l1d3SxeHnjJGF{e2G7Mli5O|IhcA>?NHXpWHVFVVORMYjJR|UxRTBwMEG4JO69VQ>?NXPKRmhuOTlyMki0NlU>
HT-29NXLlbXV4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NUXocVl2QTZiaB?=NGPHO3BFVVORMoDyTWM2OD1yLkCwNkDPxE1?NHnwPHMyQTB3M{e2Oy=>
MT4MkTQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NV\ZdVJiQTZiaB?=NGjEZY1FVVORMkjUTWM2OD1yLkCwN{DPxE1?NY\ab3puOTlyNUO3Olc>
XF498MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NGjBT5g6PiCqMki0SG1UVw>?Moq1TWM2OD1yLkG2JO69VQ>?M1jNZlE6ODV|N{[3
A2780/DX3MkXKSpVv[3Srb36gRZN{[Xl?MVWxNEDPxE1?MoDVNkBpM1S2TpNidGmwZR?=MnPIVoV3\XK|YXygc4YhWC2pcDCxO|AudWWmaXH0[YQhdXWudHnkdpVoKHKnc3nzeIFv[2ViYYPz[ZN{\WRiYYOgbY5kemWjc3WgbY4hcW62cnHj[YxtfWyjcjDkc5hwenWkaXPpckBi[2O3bYXsZZRqd25?MVWxPVA6Ozh6Mx?=
HL60M1rs[WN6fG:2b4jpZ{BCe3OjeR?=M{TUTFExOCEQvF2=NV[0W2hnPzJiaB?=MmDMSG1UVw>?NXjqVo5SUUN3ME2wMlAyQCEQvF2=MXOxPVE{PjJ4Mx?=
Hs888LuNUTXOphDS3m2b4TvfIlkKEG|c3H5MWW3NkBpMVzJR|UxRTFwNDFOwG0>NFf4V4syQTF6Nkm0Oi=>
MEFM2O3dGN6fG:2b4jpZ{BCe3OjeR?=MmTDO|IhcA>?M3vBRmlEPTB;Mz60JO69VQ>?Mmf4NVkyQDZ7NE[=
SNU398M{LvN2Fxd3C2b4Ppd{BCe3OjeR?=MoDwNVAh|ryPMWW0PEBpNUnrXmcxTE2VTx?=MVTJcoR2[3Srb36gc4Yh[XCxcITvd4l{KGG|c3Xzd4VlKGG|IHPhd5Bie2ViYXP0bZZifGmxbjD3bZRpKEWFNUCgc4YhOC5|OTFOwG0>NFjKSIsyQTJ6MkG4PC=>
T47DNEf6cIVCeG:ydH;zbZMhSXO|YYm=NHf2WpQyOCEQvF2=NGiwXVc1QCCqNGewdIVFVVORMYXJcoR2[3Srb36gc4Yh[XCxcITvd4l{KGG|c3Xzd4VlKGG|IHPhd5Bie2ViYXP0bZZifGmxbjD3bZRpKEWFNUCgc4YhOC53NzFOwG0>MWSxPVI5OjF6OB?=
SMMC-7541NXPLfHRbS3m2b4TvfIlkKEG|c3H5MXW3NkBpNYXQ[HJuUUN3ME2wMlAxOzdizszNM36wZ|E6Ojh3OE[z
NH32M{TBeWFxd3C2b4Ppd{BCe3OjeR?=NILndlgxNjFizszNM3nvTVghcA>?NHnrW|RKdmS3Y4Tpc44hd2ZiYYDvdJRwe2m|IHnuJJA2OyCmZX\pZ4lmdnRiaIXtZY4hVkh|MjDj[YxteyCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDpckBkdGWjdnXkJINie3Cjc3WgN{Bt\X[nbB?=M1e4VVE6OzR7MUe0
NH32MkTDRZBweHSxc3nzJGF{e2G7NWDjfpZwOC5zIN88US=>NVvsbFZYQCCqMnnkTY5lfWO2aX;uJI9nKGGyb4D0c5NqeyCrbjDwOVMh\GWoaXPp[Y51KGi3bXHuJG5JOzJiY3XscJMh[XO|ZYPz[YQh[XNiZHXjdoVie2ViaX6gdJJwNWOjc4Dhd4UhOyCuZY\lcC=>NUK0PXh5OTl|NEmxO|Q>
NH32NGPiXYlCeG:ydH;zbZMhSXO|YYm=M4nCVVAvOSEQvF2=NGHsWmw5KGh?MnG1TY5lfWO2aX;uJI9nKGGyb4D0c5NqeyCrbjDwOVMh\GWoaXPp[Y51KGi3bXHuJG5JOzJiY3XscJMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gVGFTWCClbHXheoFo\Q>?MVyxPVM1QTF5NB?=
NH32MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NIPxOHkxNjFizszNM3LGVVczKGh?MmfqR4VtdCCleXPs[UBienKnc4SgbY4heDV|IHTl[olkcWWwdDDoeY1idiCQSEOyJINmdGy|IHHzd4V{e2WmIHHzJIFk[3WvdXzheIlwdiCjdDDzeYIuTzBxR{GgdIhie2V?NU\6S|Z[OTl|NEmxO|Q>
TK6M1vtd2Z2dmO2aX;uJGF{e2G7MWKwMlEh|ryPMUO4JIg>NFLSbYZKdmS3Y4Tpc44hd2ZicEWzJJBpd3OyaH;yfYxifGmxbjDheEBU\XJzNTDpckBpfW2jbjDUT|Yh[2WubIOg[ZhxemW|c3nu[{B4cWymIIT5dIUheDV|M2TGdlE6OzR7MUe0
TK6NInMbppHfW6ldHnvckBCe3OjeR?=MY[wMlEh|ryPNG[3WHE5KGh?M2LYVWlv\HWldHnvckBw\iCyNUOgeJJidnOlcnnweIlwdmGuIHHjeIl3cXS7IHnuJIh2dWGwIGTLOkBk\WyuczDlfJBz\XO|aX7nJJdqdGRidInw[UBxPTNiYYPz[ZN{\WRiYYOgdFIyNUOrcEGvW4FnOSCneIDy[ZN{cW:wMYSxPVM1QTF5NB?=
TK6NEjBfXlCeG:ydH;zbZMhSXO|YYm=M3K4[lAvOSEQvF2=M1zIZVghcA>?NHfaXlNKdmS3Y4Tpc44hd2ZiYYDvdJRwe2m|IHnuJIh2dWGwIGTLOkBk\WyuczDlfJBz\XO|aX7nJJdqdGRidInw[UBxPTNiYYPz[ZN{\WRiYYOgbY5kemWjc3WgbY4h[2ynYY\l[EBk[XOyYYPlJFMhdGW4ZXy=MVmxPVM1QTF5NB?=
TK6M3O1bmFxd3C2b4Ppd{BCe3OjeR?=MXuwMlEh|ryPM1TtWFghcA>?MmrYTY5lfWO2aX;uJI9nKGGyb4D0c5NqeyCrbjDoeY1idiCWS{[gZ4VtdHNiZYjwdoV{e2mwZzD3bYxlKHS7cHWgdFU{KGG|c3Xzd4VlKGG|IHTlZ5Jm[XOnIHnuJJBzdy2lYYPwZZNmKDNibHX2[Yw>M1nVb|E6OzR7MUe0
TK6MXLBdI9xfG:|aYOgRZN{[Xl?MX[wMlEh|ryPMYO4JIg>MVrJcoR2[3Srb36gc4Yh[XCxcITvd4l{KGmwIHj1cYFvKFSNNjDj[YxteyCneIDy[ZN{cW6pIIfpcIQhfHmyZTDwOVMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gVGFTWCClbHXheoFo\Q>?NUjHS2JEOTl|NEmxO|Q>
TK6M4HlS2Z2dmO2aX;uJGF{e2G7NUTONXR1OC5zIN88US=>MXK3NkBpMnnKR4VtdCCleXPs[UBienKnc4SgbY4hcHWvYX6gWGs3KGOnbHzzJIV5eHKnc4Ppcochf2muZDD0fZBmKHB3MzDhd5Nme3OnZDDhd{Bi[2O3bYXsZZRqd25iYYSgd5VjNUdyL1exJJBp[XOnMoHMNVk{PDlzN{S=
TK6Ml\nSpVv[3Srb36gRZN{[Xl?M1PFblI2KM7:TR?=NUH6b4QzQCCqNFLTR2tKdmS3Y4Tpc44hd2ZicEWzJJBpd3OyaH;yfYxifGmxbjDheEBU\XJzNTDpckBpfW2jbjDUT|Yh[2WubIOg[ZhxemW|c3nu[{B4cWymIIT5dIUheDV|Mkj6NVk{PDlzN{S=
TK6M1exVGZ2dmO2aX;uJGF{e2G7NF3hbVQzPSEQvF2=MmLaPEBpM3vX[2lv\HWldHnvckBw\iCyNUOgeJJidnOlcnnweIlwdmGuIHHjeIl3cXS7IHnuJIh2dWGwIGTLOkBk\WyuczDlfJBz\XO|aX7nJJdqdGRidInw[UBxPTNiYYPz[ZN{\WRiYYOgdFIyNUOrcEGvW4FnOSCneIDy[ZN{cW:wNIfPZWMyQTN2OUG3OC=>
WTK1NFHsTI5HfW6ldHnvckBCe3OjeR?=M{XUSlAvOSEQvF2=MUi4JIg>M4jz[Wlv\HWldHnvckBw\iCyNUOgdIhwe3Cqb4L5cIF1cW:wIHH0JHNmejF3IHnuJIh2dWGwIGfUT|Eh[2WubIOg[ZhxemW|c3nu[{BxPTNiTUKzO2khdXW2YX70MnLzNVk{PDlzN{S=
WTK1NWHlUpJmSXCxcITvd4l{KEG|c3H5MXywMlEh|ryPMWm4JIg>NGG3UVRKdmS3Y4Tpc44hd2ZiYYDvdJRwe2m|IHnuJIh2dWGwIGfUT|Eh[2WubIOg[ZhxemW|c3nu[{BxPTNiTUKzO2khdXW2YX70JIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIHPs[YF3\WRiY3HzdIF{\SB|IHzleoVtNF7mN4EyQTN2OUG3OC=>
WTK1NV;CfYFYSXCxcITvd4l{KEG|c3H5NET3bZkxNjFizszNNGe4OWQ5KGh?MlzoTY5lfWO2aX;uJI9nKGGyb4D0c5NqeyCrbjDoeY1idiCZVFuxJINmdGy|IHX4dJJme3OrbnegdFU{KE1{M{fJJI12fGGwdDDhd5Nme3OnZDDhd{Bl\WO{ZXHz[UBqdiCycn:tZ4F{eGG|ZTCzJIxmfmWuMXOxPVM1QTF5NB?=
WTK1NWnQWHhISXCxcITvd4l{KEG|c3H5NYraTZp{OC5zIN88US=>NU\JNZo6QCCqNVXKb2QyUW6mdXP0bY9vKG:oIHHwc5B1d3OrczDpckBpfW2jbjDXWGsyKGOnbHzzJIV5eHKnc4PpcocheDV|IF2yN|dKKG23dHHueEBie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDQRXJRKGOuZXH2ZYdmMU[xPVM1QTF5NB?=
WTK1Mlz2SpVv[3Srb36gRZN{[Xl?MlTlNE4yKM7:TR?=MlTMPEBpNEK4Z2tKdmS3Y4Tpc44hd2ZicEWzJJRz[W6|Y4LpdJRqd26jbDDhZ5Rqfmm2eTDpckBpfW2jbjDXWGsyKGOnbHzzJIV5eHKnc4PpcocheDV|IF2yN|dKKG23dHHueEBie3Onc4Pl[EBieyCyMkGtR4lxOS:ZYX[xJIV5eHKnc4Ppc44>M3uz[FE6OzR7MUe0
WTK1NV;Rfm51TnWwY4Tpc44hSXO|YYm=MV2yOUDPxE1?MWC4JIg>MVHJcoR2[3Srb36gc4YheDV|IIDoc5NxcG:{eXzheIlwdiCjdDDT[ZIyPSCrbjDoeY1idiCZVFuxJINmdGy|IHX4dJJme3OrbnegdFU{KE1{M{fJJI12fGGwdB?=M2\yR|E6OzR7MUe0
WTK1MlrJSpVv[3Srb36gRZN{[Xl?MWCyOUDPxE1?NUSzXlZ3QCCqMYHJcoR2[3Srb36gc4YheDV|IITyZY5{[3KrcITpc45idCCjY4Tpeol1gSCrbjDoeY1idiCZVFuxJINmdGy|IHX4dJJme3OrbnegdFU{KE1{M{fJJI12fGGwdDDhd5Nme3OnZDDhd{BxOjFvQ3nwNU9Y[WZzIHX4dJJme3Orb36=MVyxPVM1QTF5NB?=
WTK1MlOzSpVv[3Srb36gRZN{[Xl?M{jxSFAvOSEQvF2=M4\BSlczKGh?MmDaR4VtdCCleXPs[UBienKnc4SgbY4hcHWvYX6gW3RMOSClZXzsd{BmgHC{ZYPzbY5oKHB3MzDNNlM4USCvdYThcpQh[XO|ZYPz[YQh[XNiYXPjeY12dGG2aX;uJIF1KHO3Yj3HNE9IOSCyaHHz[S=>MlfuNVk{PDlzN{S=
ECV304NUDz[olVS3m2b4TvfIlkKEG|c3H5NHLWSnQyOCEQvF2=NIS1O5I4OiCqNHrESHNEgXSxdH;4bYNqfHl?NE[xSJIyQTN4MUi5OC=>
HBL100Mn;mR5l1d3SxeHnjJGF{e2G7NW\FcllLOTBizszNMnvHO|IhcA>?MYXJR|UxRTBwMkSg{txOMmTsNVk{PjF6OUS=
PA1NXLqT4lKS3m2b4TvfIlkKEG|c3H5M{ThXlExKM7:TR?=Mo\BO|IhcA>?NES2WYFKSzVyPUCuOlMh|ryPM{Hx[|E6OzZzOEm0
A431MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NE[1TmVIUTVyPUCuNFAyOiEQvF2=NIrCU3EyQTN7NEKxPC=>
A549M3f4SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MWrHTVUxRTBwMECzJO69VQ>?NX:3ToxKOTl|OUSyNVg>
MESSANGTGe3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NULlR4lWT0l3ME2wMlAxPTFizszNNYLBOWw2OTl|OUSyNVg>
SKOV3NYfHO2dST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NYrpZ2VyT0l3ME2wMlAzOSEQvF2=NXnvSHJoOTl|OUSyNVg>
U251M4\pdGZ2dmO2aX;uJGF{e2G7MYWxJO69VQ>?MYexOkBpNUTYd4hRTE2VTx?=Mor4TY5pcWKrdHnvckBw\iCKSV[xJIFkfGm4YYTpc44hcW5iaIXtZY4hXTJ3MTDj[YxteyC|dHHicJkhfHKjboPm[YN1\WRiaX6gdGdNOi2WSz3IVmUheGyjc33p[EB4cXSqIFXDOVAhd2ZiMD6xNkDPxE1?M4K5UVE6PDB3NUC4
MDA-MB-231NV22SW5oT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=Mn7zNlAxKM7:TR?=Mm\JOFghcA>?MXvEUXNQMXjBcpRqfHWvb4KgZYN1cX[rdImgZYdicW6|dDDoeY1idiCnc4Tyc4dmdiC{ZXPldJRweiCmZX\pZ4lmdnRiTVTBMW1DNTJ|MTDj[YxteyC5aYToJGdKPTBib3[gNE4xOTB6NjFOwG0>MXqxPVQzQDF3NR?=
SNU1MWLDfZRwfG:6aXOgRZN{[Xl?NU[3b3VjUUN3ME20JO69VQ>?NEn1UmYyQTV6NUm5PC=>
SK-N-SHMlX4RZBweHSxc3nzJGF{e2G7MnnrOUDPxE1?MkfPTY5lfWO2aX;uJI9nKGGyb4D0c5NqeyCjdDCwMlUhfG9iNTD1US=>NHXNdYMyQTZ|MUW0PS=>
SK-N-SHNUnwc3ZuSXCxcITvd4l{KEG|c3H5MlfnOUDPxE1?MlHPTY5lfWO2aX;uJI9nKGGyb4D0c5NqeyCjc4Pld5Nm\CCjczDjZZNx[XOnIEOgZYN1cX[rdIm=NFHadoUyQTZ|MUW0PS=>
IMR90NXi5fXdET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MmnlO|IhcA>?M2P1cGROW09?M{PndWlEPTB;MTFOwG0>MUCxPVY{Ojh|Mx?=
L78MkjGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NG\ve5E4OiCqMUfEUXNQMmjWTWM2OD1{LkSg{txOM{S2Z|E6PjN{OEOz
MOLT4M{DtcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MmHMO|IhcA>?MVTEUXNQNUH5dpplUUN3ME2wMlAxOiEQvF2=MlrtNVk3OzJ6M{O=
OS-RC2MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M3\YTlczKGh?Mn7GSG1UVw>?M3nkW2lEPTB;NT60JO69VQ>?MYCxPVY{Ojh|Mx?=
U251MlPmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MUm3NkBpNFzjbopFVVORNEO0SphKSzVyPUCuOkDPxE1?NEfoW|QyQTZ|MkizNy=>
HCT116M3[xfWN6fG:2b4jpZ{BCe3OjeR?=MYm3NkBpNU\Jd5gyTE2VTx?=M3G3PWlEPTB;MD6wNFYh|ryPMlnPNVk3PTV5NkK=
KBMn\1R5l1d3SxeHnjJGF{e2G7NU[yUJVqPzJiaB?=MorzSG1UVw>?M{C3V2lEPTB;MD6wNFEh|ryPNUj1epRuOTl4NUW3OlI>
B16-BL6NVS2fo5NS3m2b4TvfIlkKEG|c3H5MXy3NkBpNVnHZo1HTE2VTx?=MXHJR|UxRTNwMEeg{txOMXOxPVY5QTF{NR?=
Colon 26-L5NHv6NmVEgXSxdH;4bYMhSXO|YYm=NGXnUog4OiCqNGj2WpRFVVORMWHJR|UxRTNwMUKg{txOM37GO|E6Pjh7MUK1
2008/MRP1NIDCdWpEgXSxdH;4bYMhSXO|YYm=MkXROUBlMV;EUXNQMnXLTWM2OD1yLkW3O{DPxE1?MlfzNVk4OjV3N{i=
2008/PNWrUWWJSS3m2b4TvfIlkKEG|c3H5MVu1JIQ>MnPJSG1UVw>?NYezc5FWUUN3ME2wMlA3OyEQvF2=MlnSNVk4OjV3N{i=
HL60/MX2NGTP[5BEgXSxdH;4bYMhSXO|YYm=M4\Z[VQ5KGh?M1PCWWROW09?M3L1bmlEPTB;OD6wOFYh|ryPMUmxPVc1Ozh3OB?=
MDA-MB-453NF3WZlBEgXSxdH;4bYMhSXO|YYm=NH\1dogxNjV6IN88[{9uVA>?MVG2PUBpMWHEUXNQNXLv[ZNMUUN3ME2wMlEzKM7:TR?=MmPjNVk4QDh{OUC=
HCT15MVrDfZRwfG:6aXOgRZN{[Xl?MkLzTWM2OD1yLkCzO{DPxE1?MmPZNVk5OTl4OU[=
HuCCa1MkOzR5l1d3SxeHnjJGF{e2G7M3P0NFQh\A>?MknYTWM2OD1yLk[0JO69VQ>?MlL6NVk5OjR4MUi=
MOLT3MXTDfZRwfG:6aXOgRZN{[Xl?NFLSc45KSzVyPUCuNFQh|ryPMnn5NVk5OjR4MUi=
IMR32MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M3\t[VQ5KGh?M3HOeWROW09?Ml\lTWM2OD1zLkeg{txOM3PRb|E6QTN7NUKy
MCF10AMn:zR5l1d3SxeHnjJGF{e2G7NX;PZYg{PDBizszNNXn6UHdiPDhiaB?=NHrNU5VFVVORMYXJR|UxRTBwMUig{txONIi5c|gzODB4NE[3Oi=>
MESSAMlzFSpVv[3Srb36gRZN{[Xl?Mlr6OVAh|ryPNIradYkzKGh?MYT3ZZRmeg>?M33YcWlv\HWldHnvckBw\iCGTlGg[IFu[WenIHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKGOxbXX0MZRicWxibHXu[5RpM{C1UlIxOTVzNkO5
MESSAMXvGeY5kfGmxbjDBd5NigQ>?NVuxeVM3OjVizszNMUeyJIg>M3vm[pdifGW{MYjD[YxtfWyjcjD1dJRic2V?NG\HeJczODF3MU[zPS=>
MESSA/DX5NVTlNVY1TnWwY4Tpc44hSXO|YYm=MWi1NEDPxE1?NWLxRpk5OiCqMYX3ZZRmeg>?NIjkTINKdmS3Y4Tpc44hd2ZiRF7BJIRidWGpZTDhd5Nme3OnZDDhd{BqdmO{ZXHz[UBqdiClb33leE11[WmuIHzlcod1cA>?NYDF[nA5OjBzNUG2N|k>
SKHepMVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NXe4d4tWPDhiaB?=NEXwe2dFVVORNF7qU|FKSzVyPUCuNFkh|ryPMlTiNlAyPzFzMEi=
MIAPaCa2MkT0R5l1d3SxeHnjJGF{e2G7M3Sx[VExOCEQvF2=NF3BXHU4OiCqNEKyZZlKSzVyPUCuNFEh|ryPMX[yNFIxPzB2OR?=
SKHEP1MmnnR5l1d3SxeHnjJGF{e2G7M1r3NVQ5KGh?NXv3NoxPUUN3ME2wMlAyKM7:TR?=NVzGeVdIOjB{MUCzOFY>
U87MGMoKzR5l1d3SxeHnjJGF{e2G7MWm0PEBpMoryTWM2OD1yLkCxPEDPxE1?NY\5V|I3OjB{MUCzOFY>
SK-N-MCMYPDfZRwfG:6aXOgRZN{[Xl?M17OdlczKGh?NVq5TWpDUUN3ME2wMlEzKM7:TR?=M1T3PFIxOzB|N{[4
GOTOMmT0R5l1d3SxeHnjJGF{e2G7NUfSU5B1PzJiaB?=M1X5d2lEPTB;MD6wNFQ4OyEQvF2=M2C2TVIxOzV4NkW1
HL60MYLDfZRwfG:6aXOgRZN{[Xl?M4jkOVczKGh?NIrSXZNKSzVyPUCuNFAyOTNizszNMojoNlA{PTZ4NUW=
K562MWrDfZRwfG:6aXOgRZN{[Xl?Mof0O|IhcA>?M3;JfmlEPTB;MD6wNFYyOiEQvF2=NIqwUFgzODN3Nk[1OS=>
NB-1MVXDfZRwfG:6aXOgRZN{[Xl?Mk[4O|IhcA>?MXrJR|UxRTBwMEC1NVUh|ryPNIHCdmwzODN3Nk[1OS=>
U937M4W1XGN6fG:2b4jpZ{BCe3OjeR?=MlXqO|IhcA>?M4C4T2lEPTB;MD6wNFQ1PSEQvF2=MXKyNFM2PjZ3NR?=
HBI10ANYnwTZJNS3m2b4TvfIlkKEG|c3H5M1nIUGNEPTB:MD6zJO69VQ>?M3v4elIxOzZ|MUSw
3T3M1TzPWN6fG:2b4jpZ{BCe3OjeR?=MmrBNVAh|ryPM33K[lQ5KGh?MVvJR|UxRTNwNzFOwG0>M4PWWVIxPDB3OES0
NCI/ADRNYrkRZpyS3m2b4TvfIlkKEG|c3H5NGLn[W8zPTBizsznM41NMoDJOFghcA>?MoXqS2k2OD13Lkm5JO69VQ>?NFrQUpozODRzM{G4PC=>
OVCAR-3NVXvZWM4S3m2b4TvfIlkKEG|c3H5MUOyOVAh|rypL33MMYC0PEBpMUDHTVUxRTBwMEeg{txOMXmyNFQyOzF6OB?=
PCO3NYjYZW5zS3m2b4TvfIlkKEG|c3H5M3jaUlI2OCEQvHevcWw>MUO0PEBpNYPQbGJKT0l3ME2wMlE4KM7:TR?=Mk\yNlA1OTNzOEi=
CEM/ADR5000NUjSOHRWSXCxcITvd4l{KEG|c3H5M1jSXFEh|rypL33MMorwNlQhcA>?MoP5TY5lfWO2aX;uJI9nKGGyb4D0c5Nqew>?NG\LeoczODV{N{mxOy=>
CEM/ADR5000NIrRVWNHfW6ldHnvckBCe3OjeR?=MWKxJO69\y:vTB?=NUPnZoF{PiCqMmf0TY5kemWjc3WgbY4hWk:VIHflcoVz[XSrb36=M2\JfFIxPTJ5OUG3
GXF251LNIHhd2FEgXSxdH;4bYMhSXO|YYm=MlL2NVAh|ryPMl:yNlQhcA>?MlrMTWM2OD1yLkC1NkDPxE1?NWfrSo1QOjB3NEWzN|Q>
MAXF401NLNFPLO2JEgXSxdH;4bYMhSXO|YYm=MkP0NVAh|ryPNHK3NlYzPCCqNWXNWoxOUUN3ME2wMlA2OiEQvF2=NUnHRo1UOjB3NEWzN|Q>
MEXF462NLNWruUllRS3m2b4TvfIlkKEG|c3H5NFy3NFUyOCEQvF2=M2LKSFI1KGh?NVXGdnMzUUN3ME2wMlA2OiEQvF2=MofxNlA2PDV|M{S=
PAXF1657LNYXsVHdqS3m2b4TvfIlkKEG|c3H5MmDwNVAh|ryPNUnrWG1DOjRiaB?=NXLEeGpkUUN3ME2wMlA2OiEQvF2=MWOyNFU1PTN|NB?=
HAECMXfDfZRwfG:6aXOgRZN{[Xl?MorwNVAxKM7:TR?=MoLnNlQhcA>?M3y2b2ROW09?MmDUTWM2OD1zMzFOwG0>MWiyNFU1Pzd7Nx?=
CCRF-CEMNELjPWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MkTiOFghcA>?NG[3XFBIUTVyPUCuNFIh|ryPMnTyNlA2PzBzNEW=
NUGC3NIP0XZFEgXSxdH;4bYMhSXO|YYm=MkjKS2k2OD1yLkKwNkDPxE1?M3jjW|IxPTd7OEe2
HCT-15MYrDfZRwfG:6aXOgRZN{[Xl?NHjL[VdKSzVyPUCuNFM5KM7:TR?=M3fnN|IxPTl2OES4
COLO205NFjB[|hEgXSxdH;4bYMhSXO|YYm=NGf4PW41QCCqNEPCXZBFVVORMlzWS2k2OD1yLkGg{txOMV[yNFY4OzZ{Nx?=
Hep3BM1PzbWN6fG:2b4jpZ{BCe3OjeR?=MlzxNVEh\A>?MXXJR|UxRTBwMUSg{txONWLTNlgxOjB5MUi0O|U>
SKOV3MYTDfZRwfG:6aXOgRZN{[Xl?MnjOTWM2OD1yLkCwNUDPxE1?M4LaR|IxPzF7NUC0
DWDNWjtSnBuS3m2b4TvfIlkKEG|c3H5NFLCR5c1KM7:TR?=MoLVNlQhcA>?M4fCOmdKPTB;MD6xJO69VQ>?NEjMVHEzODd|MkixOy=>
SiHaNHjrPWtEgXSxdH;4bYMhSXO|YYm=MkLTOEDPxE1?MVKyOEBpMUjHTVUxRTBwMUeg{txONEDzTZozODd|MkixOy=>
THP1NF7uR41EgXSxdH;4bYMhSXO|YYm=NX7xSI5lPzJiaB?=NGr2XXFFVVORM{nmU2lEPTB;MD6wNFgh|ryPNUjTV2NpOjB6M{OwOVc>
ARPE19M4nzemN6fG:2b4jpZ{BCe3OjeR?=M4G0RlQ5KGh?NVHrSFNHTE2VTx?=M4\TUGlEPTB;MD63OkDPxE1?NH62UIwzODl|MUm3NC=>
BJMoDwR5l1d3SxeHnjJGF{e2G7M3nPVlQ5KGh?MoDLSG1UVw>?NFHwTJlKSzVyPUKuN|Mh|ryPNU\mPWxbOjB7M{G5O|A>
KB8.5NYXObZhtS3m2b4TvfIlkKEG|c3H5Mlf5OVAh|ryPMXi3NkBpNXfPXoxwTE2VTx?=MkDLTWM2OD1|LkOg{txOMXqyNVA{PTJ|NB?=
H460NXzDd|A1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NV3QPHNLPzJiaB?=NH3zeopKSzVyPUCuNFAxOzhizszNMnO4NlExPjd7M{C=
KBM1zDTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MoXkO|IhcA>?NX3TeYR[UUN3ME2wMlAxODJ|IN88US=>M4fve|IyODZ5OUOw
MKN45MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M{XQblczKGh?NGnEfoRKSzVyPUCuNFAxOTlizszNMmDLNlExPjd7M{C=
C33ANIP6TZFEgXSxdH;4bYMhSXO|YYm=MmrsNVAxKM7:Zz;tUC=>MnzoOFghcA>?MW\JR|UxRTBwOEKg{txOMX:yNVA4OTJ{MR?=
HL60RM3Pxb2N6fG:2b4jpZ{BCe3OjeR?=MmDJNVAh|ryPNVHzeXNPPzJiaB?=MlS4SG1UVw>?NHLZXHRKSzVyPUCuPVkh|ryPNY\hdog{OjFzNEKxPFA>
MDA231NYDaV|JTS3m2b4TvfIlkKEG|c3H5MlHGNVAh|ryPNYfmdXF2PzJiaB?=NFe5UHFFVVORMYDJR|UxRTRwN4ixNE02KM7:TR?=M2S5[VIyOTR{MUiw
MDA435MV;DfZRwfG:6aXOgRZN{[Xl?M3H0[VExKM7:TR?=MonCO|IhcA>?M1;TfmROW09?NEGzZlBKSzVyPUCuNFA{PSEQvF2=MVuyNVE1OjF6MB?=
CEMMnjXR5l1d3SxeHnjJGF{e2G7MmPXO|IhcA>?Mlm0SG1UVw>?NIHzWG5KSzVyPUCuNFYh|ryPNHTGUG0zOTF2NE[yOC=>
Molt4/C8NFe0Z3REgXSxdH;4bYMhSXO|YYm=NXXvNnV4PzJiaB?=MWXEUXNQM2\QSmlEPTB;MD6yJO69VQ>?NWPJVmQzOjFzNES2NlQ>
IMR90NYHPSlY1S3m2b4TvfIlkKEG|c3H5MV:0PEBpNU\QcIg4TE2VTx?=NGTF[HBKSzVyPUCuOVkh|ryPMYqyNVIyPTZ{Mx?=
CCRFM3T5XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MVG5OkBpMUfEUXNQM2DXemlEPTB;MD6wN|c2KM7:TR?=M4PZdVIyOjl4NE[3
HepG2NFXnXmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NHnzdVI6PiCqM37idmROW09?M3qwd2lEPTB;MD6wNVkh|ryPMVGyNVI6PjR4Nx?=
HUVECMlXES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MlHNPVYhcA>?MX;EUXNQMlfiTWM2OD1yLkCzNFMh|ryPMnTnNlEzQTZ2Nke=
NCI-N87M1jZcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M2f6b|k3KGh?NHnO[nRFVVORM1nZTWlEPTB;MD60NVk5KM7:TR?=MW[yNVI6PjR4Nx?=
HCT8MnPGR5l1d3SxeHnjJGF{e2G7MVGwMlU5KM7:Zz;tUC=>M37D[FY6KGh?NF36VoxFVVORM4S1OGlEPTB;MD6wNkDPxE1?MlryNlE{QDF5MEW=
A375MkXtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NXPpb4xDPzJiaB?=MXzQRnM>M4jxcmlEPTB;MD6xN{DPxE1?MmW2NlE1QTZ7N{K=
SF295MkTmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NHjHfGMzPSCwTR?=NX;pUoZpOjRiaB?=NEnkTnFFVVORNHLBSoNKSzVyPUSuOEDPxE1?NW\MSYk{OjF3NUO4Nlk>
SK-MEL-28MkG1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MWqyOUBvVQ>?NVfRcWF7OjRiaB?=M{WwcmROW09?M3HxV2lEPTB;MD62JO69VQ>?NGLqPVQzOTV3M{iyPS=>
KATOIIIMmnuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M2LDNGlEPTB;ND6zPEDPxE1?MVqyNVU4ODd3MB?=
P388D1NHfPfmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NH\CZpVKSzVyPUCuN|M5KM7:TR?=MnO2NlE2PzB5NUC=
H22NVjLbGVJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NFfwNIM1QCCqMX7JR|UxRTN4LkWxJO69VQ>?M2TsdFIyPjJyNUK5
S180M2\kb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NVXWWpZKPDhiaB?=NFjkNG9KSzVyPUK5MlIh|ryPM4\aUVIyPjJyNUK5
SW480NHHTcFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=Ml7ROFghcA>?NWm1S4hzUUN3ME2wMlA3KM7:TR?=MoT0NlE3PDF4OUS=
HOP62MU\DfZRwfG:6aXOgRZN{[Xl?NYLz[WFvOjRiaB?=NXPRPFBXT0l3ME2wMlE1KM7:TR?=M{DselIyPjd4NUC2
BT549MV3DfZRwfG:6aXOgRZN{[Xl?NVLE[ZZ[OTZyIN88[{9uVA>?M2PTclUh\A>?MWLEUXNQM{fWcWdKPTB;MD6wNUDPxE1?M33ncVIyPzFzMEW0
Hs578Mn7wR5l1d3SxeHnjJGF{e2G7MmHnNVYxKM7:Zz;tUC=>NV;HVYhlPSCmNXTn[XRvTE2VTx?=MkTtS2k2OD1yLkCwOkDPxE1?NXH3V|B1OjF5MUGwOVQ>
NCI-H23NXnN[ZlsS3m2b4TvfIlkKEG|c3H5NHPGXFUyPjBizsznM41NM1PTbVUh\A>?MXrEUXNQM3XUSGdKPTB;MD6wNFUh|ryPM{HTZVIyPzFzMEW0
PC3NH6yOllEgXSxdH;4bYMhSXO|YYm=NWrEU5NCOTZyIN88[{9uVA>?NV;rZnN[PSCmNHyyRY1FVVORNYqyRphGT0l3ME2wMlAzOSEQvF2=MXeyNVcyOTB3NB?=
MG63MkOxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NWTYSZRQPzJiaB?=NEK3XXlKSzVyPUKuPEDPxE1?M{fYRlIyPzJzNUG5
Ew36MYHDfZRwfG:6aXOgRZN{[Xl?NFXhW4o4OiCqNUPw[|dvUUN3ME2wMlAyKM7:TR?=M3;Jb|IyPzJzNUK4
HEK293MojtR5l1d3SxeHnjJGF{e2G7MnK4O|IhcA>?MknxTWM2OD1yLkCxJO69VQ>?M{\NfVIyPzJzNUK4
HEK293NIXHZnJEgXSxdH;4bYMhSXO|YYm=M4DmfVczKGh?MmK5TWM2OD1yLkSyJO69VQ>?MXuyNVczOTV{OB?=
KB3-1M4LWNWN6fG:2b4jpZ{BCe3OjeR?=M4jiR|czKGh?MWPJR|UxRTBwMEKg{txONH;3XHQzOTd{MUWyPC=>
KBV1NYXSNnd5S3m2b4TvfIlkKEG|c3H5NI\sVXM4OiCqNGS4SVRKSzVyPUSuO{DPxE1?NU[yd2xMOjF5MkG1Nlg>
LLC-PK1MYHDfZRwfG:6aXOgRZN{[Xl?NF;sVGs4OiCqMVTJR|UxRTBwMjFOwG0>NGnvfnkzOTd{MUWyPC=>
NCI/ADR-RESM3;6N2N6fG:2b4jpZ{BCe3OjeR?=M175Z|czKGh?NGm4T25KSzVyPUmuN{DPxE1?NF3OfYIzOTd{MUWyPC=>
NIH3T3NF33UW9EgXSxdH;4bYMhSXO|YYm=NWDYXINtPzJiaB?=NFzDWWRKSzVyPUCuNFUh|ryPNHf6PGEzOTd{MUWyPC=>
SW620MoLkR5l1d3SxeHnjJGF{e2G7NXTSdoRTPzJiaB?=NYH0R4tGUUN3ME2wMlAyKM7:TR?=NFXIVlYzOTd{MUWyPC=>
ZR-75BM1nxUmN6fG:2b4jpZ{BCe3OjeR?=NV;YRVNHPzJiaB?=NVq2UGlQUUN3ME2wMlA1KM7:TR?=MoDvNlE4OjF3Mki=
ZR-75BNGXye29EgXSxdH;4bYMhSXO|YYm=NVLFNGtJPzJiaB?=MlrwTWM2OD1{LkCyJO69VQ>?NHLWWJQzOTd{MUWyPC=>
GuravNIK4NmJEgXSxdH;4bYMhSXO|YYm=M1TjelExOCEQvF2=NXnoVFV4PDhiaB?=M3;ROGROW09?MVPHTVUxRDBwMTFOwG0>NHziZ5MzOTd|N{K4PC=>
HFFMV\DfZRwfG:6aXOgRZN{[Xl?NIPweWk4OiCqNGC1PYFESzVyPUCuNFMh|ryPMn71NlE4PDFzM{G=
BT474MUjDfZRwfG:6aXOgRZN{[Xl?NHLod4o4OiCqM{m0WGlEPTB;MD6wO{DPxE1?Ml2zNlE4PDF6M{O=
ChaGoNFjHc4VEgXSxdH;4bYMhSXO|YYm=MmHxO|IhcA>?MXHJR|UxRTBwOEOg{txONXq5b2QyOjF5NEG4N|M>
KATOMmO0R5l1d3SxeHnjJGF{e2G7MVu3NkBpNEDkWWRKSzVyPUCuN|Mh|ryPM{C3XVIyPzRzOEOz
NCI-H187M{LkZWN6fG:2b4jpZ{BCe3OjeR?=NHzKNIg4OiCqNWjYOZNkUUN3ME2wMlA{KM7:TR?=MUmyNVc1OTh|Mx?=
A2780MoDiR5l1d3SxeHnjJGF{e2G7M{DvVWlEPTB;MD6wNFEzKM7:TR?=NH:2T4EzOTd5NES5PS=>
A2780/ADRMlLlR5l1d3SxeHnjJGF{e2G7NIjsZoxKSzVyPUCuNVk1KM7:TR?=MYqyNVc4PDR7OR?=
LAMA-84MljuR5l1d3SxeHnjJGF{e2G7MW[0PEBpM1GyXWlEPTB;MD63OEDPxE1?MkXYNlE4QTd{OEC=
SH-SY5YNET6RnNEgXSxdH;4bYMhSXO|YYm=NUHxU5FlPDhiaB?=M1rSTWlEPTB;MD61JO69VQ>?NV;EXYdbOjF5OUeyPFA>
Ca9-22M2n2b2N6fG:2b4jpZ{BCe3OjeR?=MlPvO|IhcA>?NXvEXlUzTE2VTx?=MX\JR|UxRTBwMk[g{txOMkP0NlE5ODB6NUm=
K562/A02NIrqTGVEgXSxdH;4bYMhSXO|YYm=NVjwTmhNPDhiaB?=NFrzeVhFVVORNH;GeVJKSzVyPUG3Mlg1KM7:TR?=NVv3UI1{OjF6NEO5OFA>
BT20MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NH63UmwyOCEQvF2=MkfqO|IhcA>?Mmj3RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdIm=MnvaNlE5PTJyMkO=
AGSNVvN[YNqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NUjTT4JiPDhiaB?=Ml7JS2k2OD1yLkCxJO69VQ>?NEDvblgzOTh5NUC0Oi=>
PC3MnzmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NU\nV2ZmPDhiaB?=NWT5[ZR2T0l3ME2wMlA6KM7:TR?=NEf2b5kzOTh5NUC0Oi=>
Neuro2aMoDGR5l1d3SxeHnjJGF{e2G7NEfGWVg4OiCqM{PvWWlEPTB;MT6yJO69VQ>?NFjZepEzOTl7NkWxPS=>
MCF7NGLHTnZHfW6ldHnvckBCe3OjeR?=MYO1NEDPxGdxbVy=NID3WFE1QCCqMVfEUXNQM2XTNnJm\HWldHnvckBqdiCYRVfGJI1TVkFiZYjwdoV{e2mxbh?=MljRNlIxODB7NE[=
MCF7M1i5VGZ2dmO2aX;uJGF{e2G7M{i4W|UxKM7:Zz;tUC=>MWS0PEBpMlLlSG1UVw>?NHqzfmZT\WS3Y4Tpc44hcW5iQ2nQNVkhdVKQQTDlfJBz\XO|aX;uNXiyZllKOjJyMEC5OFY>
MCF7NYToeZhoTnWwY4Tpc44hSXO|YYm=MXG1NEDPxGdxbVy=M1nUelQ5KGh?MljmSG1UVw>?NYHMWYh6WmWmdXP0bY9vKGmwIFHQMVIh\2GvbXGgcXJPSSCneIDy[ZN{cW:wMnzKNlIxODB7NE[=
HCT8M17lZmN6fG:2b4jpZ{BCe3OjeR?=NEDlcYU2yqEQvHevcWw>NW\F[XdEPzJiaB?=NFXPV5BFVVORNILtbIhKSzVyPUCuNFIh|ryPM1Hke|IzODByOUS5
BGC823MmCzR5l1d3SxeHnjJGF{e2G7MV[5OkBpNX7HPY1YTE2VTx?=Mkn4TWM2OD1yLkm4JO69VQ>?MnH4NlIxPzB4NUS=
SKOV3NEjXc25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MU[1NEDPxE1?NU\MW25rPzJiaB?=NELrU2xFVVORNYO3b2I6SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDTT29XOyClZXzsd{BwfmW{ZYjwdoV{e2mwZzDjMXNz[w>?NHfoTWIzOjFzOUS3Ni=>
RAW264.7NIj5SnBEgXSxdH;4bYMhSXO|YYm=NYPQSJNEOTBizszNNFHxXGwzPCCqMn76SG1UVw>?MmPLR5l1d3SxeHnjbZR6KGG|c3Xzd4VlKGG|IHPlcIwhfmmjYnnsbZR6NYnvZnQ2OjJzMkmwOlE>
A375-C5M4HBWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NYjSeHcxPDhiaB?=NYOzeW1DTE2VTx?=MmraS2k2OD1yLkC5NVUh|ryPNXHzPIhwOjJzN{e0NFk>
QGY7701Ml\jR5l1d3SxeHnjJGF{e2G7MmnKNlQhcA>?NGrxOGtFVVORMWfJR|UxRThwNkWg{txOM1noSVIzOTh{OUK2
PC3MM{jiUmN6fG:2b4jpZ{BCe3OjeR?=NHHGUWc4OiCqM4PNeWROW09?Mk\aTWM2OD1yLkK0JO69VQ>?MkjtNlIzPjRzNEm=
LNcaPMXLBdI9xfG:|aYOgRZN{[Xl?MX[yNOKh|rypL33MMlfwNlQhcA>?Mnvae4F1\XJ?MlnnTY5lfWO2aX;uJI9nKGGyb4D0c5NqeyCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDpckBk[XOyYYPlJFMwPyCjY4TpeoF1cW:wNUnVbGNuOjJ{NkS3OVg>
SKOV3M1zIV2Z2dmO2aX;uJGF{e2G7NH72d|g2KM7:TR?=MYixJIg>MVHEUXNQMmrkSJJ2\yC3cIThb4UhcW5iZH;4c5J2[mmlaX6tdoV{cXO2YX70JIh2dWGwIGPLU3Y{KGOnbHygcpVkdGW3MYKyNlI4Pjl7OB?=
SKOV3NXzvb|F6TnWwY4Tpc44hSXO|YYm=MU[1JO69VQ>?M3XhbFEhcA>?NHrLN29FVVORNXvsOJl3S2WubIXsZZIhfXC2YXvlJIlvKGSxeH;yeYJq[2mwLYLld4l{fGGwdDDoeY1idiCVS1;WN{Bk\Wyucx?=Ml7hNlIzPzZ7OUi=
B16MmfWR5l1d3SxeHnjJGF{e2G7NIi1NlI4OiCqNYTtVldtTE2VTx?=NEG3TItKSzVyPUCuNUDPxE1?M3rW[FIzOzNyNkO0
SiHaM1;DOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7Ml7pS2k2OD1yLkG0JO69VQ>?MmD6NlI{PjF4OES=
SK-N-SHM4ruOWN6fG:2b4jpZ{BCe3OjeR?=Mn7kOFghcA>?NFzpe4dKSzVyPUCuPVch|ryPMWiyNlM5PjV{OB?=
HuH7MoXrSpVv[3Srb36gRZN{[Xl?MmrnNlUhdmdxbVy=MmnZO|IhcA>?MXXEUXNQMl7zTY5lfWO2aX;uJI9nKHOnbnXzZ4Vv[2ViYYPz[ZN{\WRiYYOgbY5kemWjc3WgbY4he2WwZYPj[Y5k\SCjc4PvZ4lifGWmIHLleIEu\2GuYXP0c5Nq\GG|ZTDhZ5Rqfmm2eR?=MYOyNlQxQTd5MR?=
HuH7M2HEOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MoHyNlUhdmdxbVy=MUe3NkBpNFfPXnZFVVORM13vV2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[gRpJlXSCrbnPvdpBwemG2aX;uMmDCNlI1ODl5N{G=
K562/A02MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MWK3NkBpNV\BclNETE2VTx?=MXXBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IH31cJRq\HK3Zz3y[ZNqe3SjboSgbJVu[W5iS{W2Nk9CODJiY3XscJMhd3[ncnX4dJJme3OrbnegdE1odHmlb4Dyc5RmcW5id3n0bEBKSzVyIH;mJFQ3NjZ7IN88US=>MlH4NlI1PTBzM{S=
SK-MEL-2MmS0R5l1d3SxeHnjJGF{e2G7NXntRphPPDhiaB?=Mn34TWM2OD1yLkCwNkDPxE1?NXLwZndQOjJ2OEOzPVU>
XF498MnS4R5l1d3SxeHnjJGF{e2G7NIT6R241QCCqNYrGZ4lOUUN3ME2wMlAyPSEQvF2=NG\hS|IzOjR6M{O5OS=>
LLCNX3nSHE4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NVPnTHlmPDhiaB?=MWjJR|UxRTBwMkC3JO69VQ>?NGPLSlUzOjVzNUO2Oi=>
NCI-H290NHeyZnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M3Xp[lIh|ryPMl\VOFghcA>?MWTJR|UxRTBwM{Kg{txONWjLUIhDOjJ3MUWzOlY>
U87MGMkTsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NIXlVYwzKM7:TR?=M1WwW|Q5KGh?MV\JR|UxRTBwN{mg{txONYjwRYloOjJ3MUWzOlY>
KB/VCRNGLpWFNEgXSxdH;4bYMhSXO|YYm=M3jpflUxOCEQvF2=MV60PEBpNYLQPXNjTE2VTx?=MX7JR|UxRTBwNEWg{txOM2PxTFIzPTN5M{[y
SMMC7721MWXDfZRwfG:6aXOgRZN{[Xl?NHXCU4g2ODBizszNMl3GOFghcA>?M2LPNGROW09?MUXJR|UxRTBwM{eg{txOM3LZXlIzPTN5M{[y
786-0NXHkNlk2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NV2wZ4M{OjVizsznM41NMmnqOFghcA>?MWLJR|UxRTJwMTFOwG0>M2PoXVIzPTN5Nkiw
NCI/ADRM1HiOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MXGyOUDPxGdxbVy=MkXGOFghcA>?NYLZVpVEUUN3ME2xN{42KM7:TR?=NWrQe3oyOjJ3M{e2PFA>
SW620NIe1NpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NYnzeppEOTByIN88US=>MlLJO|IhcA>?NHLMeZRFVVORNWTyXo5vUUN3ME2wMlA1KM7:TR?=M4m1WFIzPTV3MUWy
WI38NWLLOGVZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NVLydINzOTByIN88US=>MUm3NkBpM2LReWROW09?M3nEeGlEPTB;MD6wOEDPxE1?NYD3RmhwOjJ3NUWxOVI>
J774A.1NVPYTlRjS3m2b4TvfIlkKEG|c3H5NHjxcnk4OiCqNYHB[GZmTE2VTx?=M2rWbWlEPTB;MD6wNkDPxE1?M4O0[lIzPjB6Nke1
BMDMMoPjR5l1d3SxeHnjJGF{e2G7NHvHbHozPTBizsznM41NMWi3NkBpMkTSTWM2OD12Lk[g{txOM{jDdFIzPjF4NUW0
HMEC1MkDVR5l1d3SxeHnjJGF{e2G7NWK2cIEyOjVyIN88[{9uVA>?MlPWO|IhcA>?M2C0OWlEPTB;MD6wOkDPxE1?MnLCNlI3OTZ3NUS=
MKN45NWSwbZg1S3m2b4TvfIlkKEG|c3H5MnHIOFghcA>?NV7kN5hiTE2VTx?=MYrJR|UxRTBwMU[4JO69VQ>?MlXmNlI3PDd5MkO=
B16NWS1b3F[PDhiaB?=NHG2XHpKSzVyPUCuNFMh|ryPMWeyNlY3QDR3MR?=
U2OSNIWxT2REgXSxdH;4bYMhSXO|YYm=MVy0JO69VQ>?NIrZb3E4OiCqMnXJSG1UVw>?M1TCT2lEPTB;Mz60JO69VQ>?M{PYWVIzPzR7Mke5
HCT15Mof3R5l1d3SxeHnjJGF{e2G7NH7X[og1QCCqMUXEUXNQNV\INZpDUUN3ME2wMlAxPSEQvF2=NHnqN|gzOjh3OEK5PC=>
SKLU1MXvDfZRwfG:6aXOgRZN{[Xl?NGnzVlg1QCCqNFfNWldFVVORM{ThNmlEPTB;MD6wNFY4KM7:TR?=NEPTc3YzOjh3OEK5PC=>
MESSA/DX5NW\wV4drT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MnT2NVAxKM7:Zz;tUC=>MkDLO|IhcA>?MUfEUXNQNHvSWG5KSzVyPUCuNlUh|ryPMmjENlI6PDRzMkG=
A549MY\DfZRwfG:6aXOgRZN{[Xl?NH\icIlKSzVyPUCuNFAyKM7:TR?=NGrCN4EzOjl3MUC0NC=>
HL60/AMX3DfZRwfG:6aXOgRZN{[Xl?M4e1dFE5KGh?Mle0TWM2OD14Lkeg{txOMVWyNlk5PTB{Nx?=
MG63MWnDfZRwfG:6aXOgRZN{[Xl?MXnJR|UxRTJwNzFOwG0>M{\pT|I{ODR|NEm4
BALB/3T3NX3aVZhKS3m2b4TvfIlkKEG|c3H5M2PT[lExOCEQvHevcWw>M1P2cVczKGh?M3z5UmROW09?M{PEWWlEPTB;MT65NUDPxE1?MYCyN|A4QTV{Mx?=
HL60/VincNVW3WW43S3m2b4TvfIlkKEG|c3H5MYmxNFAh|rypL33MMYi3NkBpMl3xSG1UVw>?M33ISmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KH[rbnPybZN1cW6nLYLld4l{fGGwdDDoeY1idiCKTE[wM3ZqdmNiY3XscJMhf2m2aDDJR|UxKG:oIECuPVEh|ryPMYGyN|A4QTV{Mx?=
Bcap37NEHud4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NWq5bpR{OjBizszNMXS3NkBpNX\5VYZ{TE2VTx?=NUf1U4tQUUN3ME2xMlI5KM7:TR?=M2n1bVI{OTJ2MkGw
MGC803NWPTdZFLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NXG0RpRiOjBizszNMoHlO|IhcA>?M1rRcmROW09?NWjsbJJJUUN3ME2wMlch|ryPMVeyN|EzPDJzMB?=
MOLT4NFXycItEgXSxdH;4bYMhSXO|YYm=NYjzfGR[PDhiaB?=M1e0S2ROW09?MUXJR|UxRTBwMEKg{txOM33kSVI{OjF6N{G4
WHCO1NWL3dpFOS3m2b4TvfIlkKEG|c3H5NUjyV2E1PDhiaB?=NHjVVYNFVVORM1[3bGlEPTB;MD61JO69VQ>?MYOyN|M2Ozd2Nx?=
AT6-1NYj3W411T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M1zGd|czKGh?MVTJR|UxRTJizszNMnzCNlM{PjB3MkG=
L929MlPOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NX;hVmVoPzJiaB?=MVvJR|UxRTBwMU[xJO69VQ>?MknHNlM{PjB3MkG=
OSRGANFzaT4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NFHyR2o4OiCqNXK1R4VOUUN3ME2wMlA6OyEQvF2=NWjP[ZI5OjN|NkC1NlE>
POS1M2TlVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NVzy[YlZPzJiaB?=MoDpTWM2OD1yLkC0N{DPxE1?M1X2XFI{OzZyNUKx
HeLaNV;yPGNGS3m2b4TvfIlkKEG|c3H5NV\Wdno6OSEQvF2=MkPmO|IhcA>?NWrhWJRpUUN3ME2wMlAyKM7:TR?=NFv1TJQzOzR5MEGzPS=>
SK-MELNYP5UJBES3m2b4TvfIlkKEG|c3H5M2jGOFQ5KGh?MUfEUXNQNH;VRZNKSzVyPUGuOUDPxE1?NWDNXnBqOjN3NEe4OFM>
MA9.3MVfDfZRwfG:6aXOgRZN{[Xl?M33MUlExOCEQvF2=MlXTOFghcA>?MmTTTWM2OD1yLkC4OkDPxE1?NWCwTJdpOjN3N{i2PVA>
A673M4rle2N6fG:2b4jpZ{BCe3OjeR?=MnruO|IhcA>?NEPM[opEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPjd|IHPlcIx{KGGodHXyJFczKGi{czDifUBz\XOjeoXybY4wemW|b4L1[olvNWKjc3XkJIZtfW:{ZYPj[Y5k\SCjc4PhfUB4cXSqIFnDOVAhd2ZiMD6xO{DPxE1?MUSyN|YxODl{NR?=
A673NVvoT4FiSXCxcITvd4l{KEG|c3H5Mn7wNlQhcA>?MlXnSG1UVw>?M1\2R2lv\HWldHnvckBw\iCjcH;weI9{cXNiYYPz[ZN{\WRiYYOgZ4F{eGG|ZT2zJIFkfGm4YYTpc44hf2m2aDDFR|UxKG:oIECuN|kh|ryPNEf1OmQzOzZyMEmyOS=>
MDA-MB-436MnH5R5l1d3SxeHnjJGF{e2G7M1XzflczKGh?NGr6dGNKSzVyPUCuNUDPxE1?NEfQNGozOzZyMEmyOS=>
MNNG-HOSM1\QZ2N6fG:2b4jpZ{BCe3OjeR?=MoPiO|IhcA>?NYfjbpY5UUN3ME2wMlU6KM7:TR?=Ml\1NlM3ODB7MkW=
NCI-H929MWDDfZRwfG:6aXOgRZN{[Xl?NFPEfZc4OiCqNX3HZYhoUUN3ME2wMlA3PSEQvF2=MVqyN|YxODl{NR?=
SK-BR-3M3;id2N6fG:2b4jpZ{BCe3OjeR?=MXW3NkBpMYPJR|UxRTBwMEmg{txOM1nXWFI{PjByOUK1
SK-ES-1M4[1TGN6fG:2b4jpZ{BCe3OjeR?=MUO3NkBpMojUTWM2OD1yLkC0NkDPxE1?MYiyN|YxODl{NR?=
SK-UT-1M3XLZmN6fG:2b4jpZ{BCe3OjeR?=NVzVdmZtPzJiaB?=NID1T29KSzVyPUCuNFc3KM7:TR?=M3yxZlI{PjByOUK1
SW872MYPDfZRwfG:6aXOgRZN{[Xl?NI\ERYU4OiCqMWrJR|UxRTBwMUSg{txONIHQPYwzOzZyMEmyOS=>
U266M13KOmN6fG:2b4jpZ{BCe3OjeR?=NHHrbWg4OiCqM1HqcGlEPTB;MD62O{DPxE1?NH\oUmMzOzZyMEmyOS=>
JURKAT-TALLNF:5dY9EgXSxdH;4bYMhSXO|YYm=NYTQfXN2PDhiaB?=MWPJR|UxRTBwMEC5OkDPxE1?NH;lNnAzOzZ5M{KxPC=>
B16F10NHjQcWREgXSxdH;4bYMhSXO|YYm=M1Sy[VQ5KGh?NXvYeot1TE2VTx?=MYfJR|UxRTBwMEeyJO69VQ>?M2Xy[|I{Pzd5OEm4
C643MUnDfZRwfG:6aXOgRZN{[Xl?MUOyOUBuVQ>?NG\sOnozPCCqMYHJR|UxRTBwMEeg{txOMUeyN|gxOjdzNh?=
HGFM1XqRWN6fG:2b4jpZ{BCe3OjeR?=NGDofGEzPSCvTR?=M1\ne|I1KGh?M3S0cWlEPTB;MD61JO69VQ>?MWSyN|gxOjdzNh?=
786M2\i[GN6fG:2b4jpZ{BCe3OjeR?=NVX6dlNoPDhiaB?=MVPEUXNQM2j5WmlEPTB;MD6zN{DPxE1?NWrxUGo2OjN6MUCyPFI>
LS180NFnYfnZEgXSxdH;4bYMhSXO|YYm=M2\FNVczKGh?MkfLSG1UVw>?NHqxbndKSzVyPUCuNFQh|ryPM{PNdVI{QDJ5MUe5
COLO205MlX0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NXG5W2lMOTByIN88US=>MX20PEBpMUHHTVUxRTBwMUSg{txOMX2yN|g1QTJyNx?=
DWDMVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MkHSNVAxKM7:TR?=NXrqbYI1PDhiaB?=NIT3UHRIUTVyPUCuNUDPxE1?M4CzcFI{QDR7MkC3
GuravNU\yPJZnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M4PtW|ExOCEQvF2=MlLqOFghcA>?M3nhfWdKPTB;MD6xO{DPxE1?M{HqV|I{QDR7MkC3
HOP62M3\ae2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7M2POUVExOCEQvF2=MX[0PEBpNGfB[5VIUTVyPUCuNVQh|ryPM2r6fVI{QDR7MkC3
786-0MYLDfZRwfG:6aXOgRZN{[Xl?NV;ESpdDOTByIN88US=>M4LyNlQ5KGh?NEP6fXpIUTVyPUCuNVMh|ryPNVLZPGkxOjN6N{G5NFU>
ACHNM{WzVGN6fG:2b4jpZ{BCe3OjeR?=NW\U[Zp[OTByIN88US=>MmDIOFghcA>?MoW4S2k2OD1yLkC4JO69VQ>?Ml[wNlM5PzF7MEW=
Caki1NHy4fmZEgXSxdH;4bYMhSXO|YYm=NWLpN3RSOTByIN88US=>MkLwOFghcA>?MXnHTVUxRTBwOUWg{txOMkn4NlM5PzF7MEW=
EKVXNFPCdoZEgXSxdH;4bYMhSXO|YYm=NI\4fZYyODBizszNNEDCSG41QCCqNVHBTVNvT0l3ME2wMlQyKM7:TR?=M3PtNVI{QDdzOUC1
HCC2998MnTJR5l1d3SxeHnjJGF{e2G7MVOxNFAh|ryPNEfyOo41QCCqM4\4VmdKPTB;MD6yOkDPxE1?MX[yN|g4OTlyNR?=
HOP92MliwR5l1d3SxeHnjJGF{e2G7M4\2ZVExOCEQvF2=NVzPcop5PDhiaB?=MXfHTVUxRTBwMTFOwG0>NWe2fI1{OjN6N{G5NFU>
IGROVINInjcoVEgXSxdH;4bYMhSXO|YYm=NXHqbIdsOTByIN88US=>NVvj[mw3PDhiaB?=MUnHTVUxRTBwMUeg{txONHfLS28zOzh5MUmwOS=>
KM12MkjXR5l1d3SxeHnjJGF{e2G7NWT6W497OTByIN88US=>NX3JXnM1PDhiaB?=M37MSWdKPTB;MD6yO{DPxE1?MkjxNlM5PzF7MEW=
LOXIMVIMl36R5l1d3SxeHnjJGF{e2G7MVixNFAh|ryPNWrKTIh4PDhiaB?=M33HdmdKPTB;MD6wO{DPxE1?M2XCXlI{QDdzOUC1
M14MUXDfZRwfG:6aXOgRZN{[Xl?MX6xNFAh|ryPNYXHUVZ4PDhiaB?=NH2wXmlIUTVyPUCuNVgh|ryPM3fPfVI{QDdzOUC1
MALME-3MM2r1UGN6fG:2b4jpZ{BCe3OjeR?=NGCwbZYyODBizszNM3jub|Q5KGh?MYPHTVUxRTBwMUKg{txOMWCyN|g4OTlyNR?=
NCI-H226M2TaWWN6fG:2b4jpZ{BCe3OjeR?=MYmxNFAh|ryPMWW0PEBpMn62S2k2OD1yLkC1JO69VQ>?Mmj3NlM5PzF7MEW=
NCI-H322MNHvrNmdEgXSxdH;4bYMhSXO|YYm=M4XFPVExOCEQvF2=M{SwZVQ5KGh?NHKySXpIUTVyPUCuOVQh|ryPNUThR4NQOjN6N{G5NFU>
NCI-H522M{DpfGN6fG:2b4jpZ{BCe3OjeR?=M2C2[VExOCEQvF2=NH2wOoc1QCCqMU\HTVUxRTBwMEOg{txONWW2R4tuOjN6N{G5NFU>
OVCAR4NFfhXXhEgXSxdH;4bYMhSXO|YYm=NXnvSphkOTByIN88US=>NXTtbIdKPDhiaB?=NIjxOlZIUTVyPUCuN|ch|ryPNHjzV4kzOzh5MUmwOS=>
OVCAR5M3TVfGN6fG:2b4jpZ{BCe3OjeR?=NVTpdJZHOTByIN88US=>M2K1O|Q5KGh?M4TFemdKPTB;MD60NUDPxE1?M3\pW|I{QDdzOUC1
OVCAR-8MYjDfZRwfG:6aXOgRZN{[Xl?NY\rO4hEOTByIN88US=>M2TUZVQ5KGh?MkPmS2k2OD1yLkGg{txONGPOU5UzOzh5MUmwOS=>
PRMI8226Mnm0R5l1d3SxeHnjJGF{e2G7NVy5flUzOTByIN88US=>MnKxOFghcA>?NVrTcoZ5T0l3ME2wMlA5KM7:TR?=NV\uOYJWOjN6N{G5NFU>
RXF393M4HnemN6fG:2b4jpZ{BCe3OjeR?=MoL2NVAxKM7:TR?=NHP1WGg1QCCqMmXkS2k2OD1yLkGg{txOM2n5NVI{QDdzOUC1
SF539MXjDfZRwfG:6aXOgRZN{[Xl?M1;ZV|ExOCEQvF2=MUm0PEBpMWDHTVUxRTBwMUKg{txONHvHU3kzOzh5MUmwOS=>
SK-MEL-28NWfLVY1MS3m2b4TvfIlkKEG|c3H5NFq3TJQyODBizszNM3u5NVQ5KGh?MlLYS2k2OD1yLkKxJO69VQ>?M3q5V|I{QDdzOUC1
SN12CMUTDfZRwfG:6aXOgRZN{[Xl?NGH6c3oyODBizszNNWfs[FhmPDhiaB?=M3\u[WdKPTB;MD6wO{DPxE1?NYLiSmRDOjN6N{G5NFU>
SNB19M{\jcmN6fG:2b4jpZ{BCe3OjeR?=NHr4N3MyODBizszNMl31OFghcA>?MXPHTVUxRTBwMESg{txOMUWyN|g4OTlyNR?=
SNB75M2X5VmN6fG:2b4jpZ{BCe3OjeR?=MlrrNVAxKM7:TR?=M3PpV|Q5KGh?NXPkOoJbT0l3ME2wMlA4KM7:TR?=NWr0fW5zOjN6N{G5NFU>
SRNXjMZotES3m2b4TvfIlkKEG|c3H5NHTUd4gyODBizszNM2SxNlQ5KGh?MYfHTVUxRTBwMEOg{txOMXKyN|g4OTlyNR?=
TK10M3yzPGN6fG:2b4jpZ{BCe3OjeR?=M1L6TlExOCEQvF2=NXXKZYp[PDhiaB?=NInITXhIUTVyPUCuNVgh|ryPNXrBN3ZHOjN6N{G5NFU>
U251NYXMb5NiS3m2b4TvfIlkKEG|c3H5MVGxNFAh|ryPM4nRd|Q5KGh?MYHHTVUxRTBwMESg{txOM13OZlI{QDdzOUC1
UACC257NXHrV|l[S3m2b4TvfIlkKEG|c3H5M3TINlExOCEQvF2=MX:0PEBpMXjHTVUxRTBwMUSg{txONYXXOJNYOjN6N{G5NFU>
UO31NVXWfXQyS3m2b4TvfIlkKEG|c3H5M1rOeFExOCEQvF2=MWe0PEBpMkTzS2k2OD1yLkS5JO69VQ>?NF62WYkzOzh5MUmwOS=>
HaCaTM3fnXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M2\0dFI2KM7:Zz;tUC=>NVq5XY1yPDhiaB?=NFjjbXpVT0l3ME2wMlQh|ryPNHj1RYkzOzh5NkOzPC=>
H9c2MmPuSpVv[3Srb36gRZN{[Xl?NYXKS4hpPSEQvF2=MUKyOEBpM4TMcmFvfGmxeHnkZY51KGGldHn2bZR6KGG|c3Xzd4VlKGG|IHnueJJidWm2b3Poc45lemmjbDDSU3MhdGW4ZXy=M3XFNVI{QTd|MkGz
H9c2Mn;rSpVv[3Srb36gRZN{[Xl?MUe1JO69VQ>?NWrwdWZMOjRiaB?=MnTYRY51cW:6aXThcpQh[WO2aY\peJkh[XO|ZYPz[YQh[XNiaX70doFk\WyudXzhdkBu[Wyxbons[IlidGSnaInk[UBt\X[nbB?=NEDQWGIzOzl5M{KxNy=>
H9c2NHHoTZFHfW6ldHnvckBCe3OjeR?=NIHlUoo2KM7:TR?=Mkn1NlQhcA>?M2fkVWFvfGmxeHnkZY51KGGldHn2bZR6KGG|c3Xzd4VlKGG|IHnueJJi[2WubIXsZZIhWk:VIHzleoVtMWGyN|k4OzJzMx?=
H9c2NUm2XG1qTnWwY4Tpc44hSXO|YYm=Mn3uOUDPxE1?MkXoNlQhcA>?MlHTR4VtdHWuYYKgeZB1[WunMnjhNlM6PzN{MUO=
MCF7MY\GeY5kfGmxbjDBd5NigQ>?MWK1JO69VQ>?NHLSUHgzPCCqM{[2eWFvfGmxeHnkZY51KGGldHn2bZR6KGG|c3Xzd4VlKGG|IHnueJJidWm2b3Poc45lemmjbDDSU3MhdGW4ZXy=NF7DUIUzOzl5M{KxNy=>
MCF7MXjGeY5kfGmxbjDBd5NigQ>?M3XMNVUh|ryPM2fTWlI1KGh?NXzzXItnS2WubIXsZZIhfXC2YXvlM4nUUlI{QTd|MkGz
MCF7M3j5TmZ2dmO2aX;uJGF{e2G7MlmyOUDPxE1?M4TsVVI1KGh?MmL2RY51cW:6aXThcpQh[WO2aY\peJkh[XO|ZYPz[YQh[XNiaX70doFk\WyudXzhdkBu[Wyxbons[IlidGSnaInk[UBt\X[nbB?=MYKyN|k4OzJzMx?=
MCF7M4rBUmZ2dmO2aX;uJGF{e2G7MWS1JO69VQ>?MWOyOEBpMnLWR4VtdHWuYYKgeZB1[WunNFO0eogzOzl5M{KxNy=>
MDA-MB-231NE[xUVRHfW6ldHnvckBCe3OjeR?=NFTCcY82KM7:TR?=M13TeFI1KGh?MXvD[YxtfWyjcjD1dJRic2V?MoLmNlM6PzN{MUO=
MDA-MB-231M3fKPWZ2dmO2aX;uJGF{e2G7MX61JO69VQ>?MmPiNlQhcA>?MlPJRY51cW:6aXThcpQh[WO2aY\peJkh[XO|ZYPz[YQh[XNiaX70doFk\WyudXzhdkBu[Wyxbons[IlidGSnaInk[UBt\X[nbB?=NHrmN3MzOzl5M{KxNy=>
MDA-MB-231NVvj[5hOTnWwY4Tpc44hSXO|YYm=Mo\4OUDPxE1?NWXPd25kOjRiaB?=NFGxT2JCdnSrb4jp[IFvfCCjY4Tpeol1gSCjc4Pld5Nm\CCjczDpcpRz[W2rdH;jbI9v\HKrYXygVm9UKGyndnXsMYeyN|k4OzJzMx?=
KB/HeLaMXnDfZRwfG:6aXOgRZN{[Xl?NUHnenJyPDViaB?=NUi2NmtTTUN3ME2wMlI2KM7:TR?=MkHZNlM6QDh|NUG=
HUVECMYnDfZRwfG:6aXOgRZN{[Xl?NWSwfm9yPDhiaB?=M13mbWlEPTB;MD6wPFA4KM7:TR?=M{fOVVI1ODF{M{e4
HepG2NEHrd4VHfW6ldHnvckBCe3OjeR?=MmTKOFAh|rypL33MMWi0PEBpMmH6SG1UVw>?NFG2dmVKdmirYnn0bY9vKG:oIGTST{B4cXSqIFnDOVAhd2ZiMD6wNFI2KM7:TR?=NUGyWlE1OjRyMUO0NVE>
MRC5M3XCV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MW[3NkBpNHLHSWhKSzVyPUCuNUDPxE1?NIfyRWozPDB{MUS2Ni=>
HUVECM4C2XGZ2dmO2aX;uJGF{e2G7MlS3OUDPxE1?MYSyJIg>NYfZ[pB7S2WubIXsZZIhfXC2YXvlNUHrfmc6OjRyMki0OFY>
MDA-MB-435MmnjR5l1d3SxeHnjJGF{e2G7Mk\ONVAxKM7:TR?=MXi0PEBpNEj5fYxKSzVyPUCuNVUh|ryPNVSwN|hYOjRyMki0OFY>
AS49-RAWM{HKOWN6fG:2b4jpZ{BCe3OjeR?=M2jCXFExOCEQvF2=MWm0PEBpM4\iO2lEPTB;M{KuO|gh|ryPNYrKVFlkOjRyN{e1Nlg>
Caov3NX;0cI1UT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NWmy[VQ{PzJiaB?=NXjwWYt6UUN3ME2wMlEh|ryPMlf1NlQxQTVyOEm=
LNcaPMUjGeY5kfGmxbjDBd5NigQ>?MkLiN{DPxE1?NVnncVlTOjRiaB?=NFvWcZNKdmO{ZXHz[UBw\iClbHXheoVlKGOjc4Dhd4UuQSCuZY\lcC=>M33melI1ODl3MEi5
LNcaPMWTGeY5kfGmxbjDBd5NigQ>?M1n2[|Mh|ryPNFWweoQzPCCqNXjRZ2tvXXBvcnXneYxifGmxbjDv[kBxPTNiZYjwdoV{e2mxbh?=M3:wV|I1ODl3MEi5
OVCAR8NHXLdHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MnW0NlAh|ryPMWO3NkBpMmXrRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdIm=NEmzbXYzPDB7NUC4PS=>
U2OSNXLJdVBrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M1faN|czKGh?MlLJTWM2OD1yLkOg{txONXHnfox1OjRyOUWwPFk>
Caco2M1XoW2N6fG:2b4jpZ{BCe3OjeR?=NU[zWWJWPDBizszNMXOyOEBpNFHCOnZEgXSxdH;4bYNqfHl?M1jDNFI1ODl7OUm0
MDA-MB-468NHPwe|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M1vhbVExKM7:TR?=MX63NkBpNFfIeIJIUTVyPUCuNFg2KM7:TR?=NH7UUFYzPDF4M{eyPS=>
Caco2NXf0c4Z3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M2\UNFQ5KGh?NHLIbXhIUTVyPUCuN|Ih|ryPMmnDNlQyQDRyN{[=
MKN28Mnj0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M3XFflQ5KGh?M{\nbmdKPTB;MD6yOEDPxE1?M3rQU|I1OTh2MEe2
SGC7901M3XLfWN6fG:2b4jpZ{BCe3OjeR?=NFXsSJdKSzVyPUCuNFEyKM7:TR?=M33LRVI1OTl3NE[2
Bel7402NWTCVHdHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MmXpPVYhcA>?MmDjSG1UVw>?M4\CfmlEPTB;MD61O|gzKM7:TR?=NEjIUpozPDJzMU[zPS=>
CHP100M4G0c2N6fG:2b4jpZ{BCe3OjeR?=Mnu4O|IhcA>?NGryb4NKSzVyPUCuO|kh|ryPMkXtNlQzPTF2MUe=
MGC803MnP4R5l1d3SxeHnjJGF{e2G7M1fDelczKGh?M4\Cb2lEPTB;MD6xO{DPxE1?Mon4NlQ{PzBzMUS=
ME180MVLDfZRwfG:6aXOgRZN{[Xl?NH[wOXk1QCCqMoHVTWM2OD1yLkO5JO69VQ>?Ml\3NlQ1QDdzOEi=
L929NF;mPHREgXSxdH;4bYMhSXO|YYm=NILrTXEyNjFyIN88US=>NEPjOoM4OiCqNYXwfpVKTE2VTx?=NWHlNVFqUUN3ME2wMlE3KM7:TR?=M4PMblI1PTNyMEOw
MX1NGTjb5dEgXSxdH;4bYMhSXO|YYm=M2fYOlEvOTBizszNM3LvXFczKGh?NUnHVIlTTE2VTx?=M2DQUWlEPTB;MD61JO69VQ>?MX6yOFU{ODB|MB?=
V79MlXZR5l1d3SxeHnjJGF{e2G7NIDIc44yNjFyIN88US=>M1zwR|czKGh?M{\GbWROW09?MWrJR|UxRTBwMkSg{txONIDSe3UzPDV|MECzNC=>
CCRF-CEMMlf4R5l1d3SxeHnjJGF{e2G7MX\EUXNQNVvCOJFUUUN3ME2wMlAxQSEQvF2=NHHDWmQzPDV4MU[3NC=>
CEM/ADR5000NELxNoJEgXSxdH;4bYMhSXO|YYm=NELlNlFFVVORMYHDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDteYx1cWS{dXetdoV{cXO2YX70JGNGVS:DRGK1NFAxKGOnbHzzJIV5eHKnc4PpcocheC2pbInjc5Bzd3SnaX6ge4l1cCCLQ{WwJI9nKDJ|LkK3JO69VQ>?NH3SbGgzPDV4MU[3NC=>
26-L5M1OzNGZ2dmO2aX;uJGF{e2G7MmOwOkBpMV;BcpRqcW64YYPpeoUh[WO2aY\peJk>NH;NNJYzPDV7Mkm5Ny=>
BALB/3T3NH34dlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M2e2O2lEPTB;MD61JO69VQ>?NWO2UpZbOjR4M{GxPVA>
16HBENH3kSVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NWDSWI5rOTBizszNNXzxeIdRPzJiaB?=M3mzbmROW09?M1zvWWdKPTB;MD6xPEDPxE1?MkTjNlQ3PTB4NEO=
HLFMkTDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MX[xNEDPxE1?Mon3O|IhcA>?MVPEUXNQNI\1THBIUTVyPUCuN|Mh|ryPM2rQcFI1Pjh4MEGx
SGC7901M37Zb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NXvDfWJ1OTBizszNMl3yO|IhcA>?NUPFNoNVTE2VTx?=M2rpbGdKPTB;MD61OUDPxE1?MX:yOFY5PjBzMR?=
A431MUXDfZRwfG:6aXOgRZN{[Xl?NUnBVVdVUUN3ME2wMlAxOTN3IN88US=>NVTx[lBrOjR6OUC2OVI>
HT-29MY\GeY5kfGmxbjDBd5NigQ>?NF7MWGozPSEQvF2=MV[yOEBpMX3Jcohq[mm2aX;uJI9nKE2UUEOtcYVlcWG2ZXSg[JJ2\yC{ZYPpd5RidmOnIHnuJIRwgG:{dXLpZ4lvNXKnc3nzeIFvfCCqdX3hckBJXC1{OTDj[YxteyCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDpckBlenWpIHHjZ5VufWyjdHnvci=>M2nO[lI1QTByM{O3
HT-29NFn1eIZHfW6ldHnvckBCe3OjeR?=NWro[WZkPSEQvF2=MnPUNlQhcA>?M4fBPGlvcGmkaYTpc44hd2ZiTWLQN{BqdiCmb4jvdpVjcWOrbj3y[ZNqe3SjboSgbJVu[W5iSGStNlkh[2WubIOgZZN{\XO|ZXSgZZMhdmm2cnH0bY9vKG:oIIT5do9{cW6nIILld4llfWW|MXmyOFkxODN|Nx?=
HT-29MYTGeY5kfGmxbjDBd5NigQ>?NUXiXmpuPSEQvF2=M3LFWFEhcA>?MYHJcohq[mm2aX;uJI9nKE2UUEOtcYVlcWG2ZXSg[JJ2\yC{ZYPpd5RidmOnIHnuJIRwgG:{dXLpZ4lvNXKnc3nzeIFvfCCqdX3hckBJXC1{OTDj[YxteyCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDpckBlenWpIHHjZ5VufWyjdHnvci=>MVmyOFkxODN|Nx?=
HT-29M3TCSGZ2dmO2aX;uJGF{e2G7MX21JO69VQ>?NYn3UolSOSCqNHLSUZZKdmS3Y4Tpc44hd2Zibnn0dol1\SCycn;keYN1cW:wIHnuJIRwgG:{dXLpZ4lvNXKnc3nzeIFvfCCqdX3hckBJXC1{OTDj[Yxtew>?MVmyOFkxODN|Nx?=
NARNFjscm5HfW6ldHnvckBCe3OjeR?=MW[1JO69VQ>?NV:yTVBDOiCqMnnlSJJ2\yC3cIThb4UhcW5iZH;4c5J2[mmlaX6tdoV{cXO2YX70JIh2dWGwIF7BVkBk\WyuIIDsZZNu[SCvZX3idoFv\Q>?NYf1SXR[OjR7MECzOFQ>
NARNUjUb2xIS3m2b4TvfIlkKEG|c3H5MlK0NVAh|ryPMl64NlQhcA>?Mn30R5l1d3SxeHnjbZR6KGG|c3Xzd4VlKGG|IHnu[JVkfGmxbjDv[kBk\WyuIHTlZZRpNX\2XpVGOjR7MECzOFQ>
NARM{HRNGN6fG:2b4jpZ{BCe3OjeR?=NUntNVhyOTByIN88US=>NYXxSXMyOjRiaB?=M3[3VGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGSxeH;yeYJq[2mwLYLld4l{fGGwdDDoeY1idiCQQWKgZ4VtdHNiYYPz[ZN{\WRiYYOgZ4VtdCC4aXHibYxqfHl?NYGzbJZZOjR7MECzOFQ>
DA-3NVvPXHZkS3m2b4TvfIlkKEG|c3H5MlP2OlAh|ryPMUCyOEBpNGnqRZlKSzVyPUSg{txOMVWyOFkxODZ4OB?=
DA-3M3\HXmZ2dmO2aX;uJGF{e2G7M3j0[|ExKM7:TR?=MoHXNVAhcA>?MnSyR4VtdHWuYYKgeZB1[WunIHnuJI1wfXOnIFTBMVMh[2WubDDtbZRw[2ixbnTybYE>NV7xPWpsOjR7MEC2Olg>
DA-3Ml;ZSpVv[3Srb36gRZN{[Xl?MlX4NVAh|ryPMWWxNEBpMXXD[YxtfWyjcjD1dJRic2ViaX6gcY92e2ViRFGtN{Bk\WyuIHz5d49{d22nNHnJb3EzPDlyME[2PC=>
DA-3NWLuWFFuTnWwY4Tpc44hSXO|YYm=MlHsNVAh|ryPM4T1TlExKGh?MmLlR4VtdHWuYYKgeZB1[WunIHnuJI1wfXOnIFTBMVMh[2WubDDueYNt\XW|NVTtN3NTOjR7MEC2Olg>
YOYO1MVzGeY5kfGmxbjDBd5NigQ>?M3X2UWRqe3CuYXPlcYVvfCCxZjDZU3lQOSCocn;tJJBp[WenIHzhcYJl[SCGTlGge4l1cCCLQ{WwJI9nKDBwNjFOwG0>NH\3Um4zPDlyME[2PC=>
KCL22NE\NSnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M2GyWVQ5KGh?NWfNN3lXUUN3ME2xMlgh|ryPNHPjPXgzPDl2MUGyPS=>
Saos2M16ycWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NX7scnB4PDBizszNNFrqNmEzPCCqM4f5fGROW09?MlPoTWM2OD1yLkOzJO69VQ>?MnnvNlQ6PDFzM{C=
IMR32NXy2UpN4S3m2b4TvfIlkKEG|c3H5NX3Zb2RTOjVyIN88US=>NES4OGc1QCCqNXP2RVNtTE2VTx?=NWDjZ2tPUUN3ME2wMlAxPTFizszNNVXuPZRDOjR7OU[xOFA>
NTERA-S-cl-D1NGf0T4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M2PtfmlEPTB;MT6zO{BvVQ>?NEXPNGxUSU6JRWK=
EW-16NGX3UXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MYHJR|UxRTFwOUGgcm0>M3HYVHNCVkeHUh?=
HUTU-80NWj4RnFPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NXX1THdxUUN3ME2yMlEzKG6PMWPTRW5ITVJ?
KS-1M{XUOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NG[wfGZKSzVyPUOuOFQhdk1?MV;TRW5ITVJ?
HT-144NILpdFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=Mn7YTWM2OD1|LkWxJI5ONIXldmlUSU6JRWK=
MFH-inoNUT4Z4t1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=Mo\TTWM2OD1|Lkm5JI5OMkXEV2FPT0WU
LC-2MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NH3vZZVKSzVyPUWuNFchdk1?NIW1XVhUSU6JRWK=
SW982M4m3VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M3n1VmlEPTB;Nj6wOUBvVQ>?NX22bmxYW0GQR1XS
ES4NX7SbZVCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MYLJR|UxRTZwMUGgcm0>NWTmXm0yW0GQR1XS
KGNNULuTmVjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NEX5UW1KSzVyPU[uN|Qhdk1?MYLTRW5ITVJ?
RH-1MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MUTJR|UxRTZwN{Ogcm0>MnX0V2FPT0WU
IGROV-1M2S0UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NYXUWGtIUUN3ME23MlIhdk1?NX;iUppmW0GQR1XS
KYSE-270NHLzc2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NX7GbI1SUUN3ME23MlIyKG6PNVezWm96W0GQR1XS
TE-8MoHBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M37ld2lEPTB;Nz61JI5OMWfTRW5ITVJ?
DaoyMX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NXHnNGF6UUN3ME24MlA4KG6PMnrSV2FPT0WU
REHNUfHbHhXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=Mk\2TWM2OD16LkGxJI5ONIDTUnVUSU6JRWK=
786-0NGjlVopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NXXUTFJMUUN3ME24MlQ4KG6PMXvTRW5ITVJ?
A375NGi4eIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M2f4WmlEPTB;OT6xO{BvVQ>?M4PtPHNCVkeHUh?=
EW-13NFTvSmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MluzTWM2OD17Lk[zJI5OMlnpV2FPT0WU
MKN1NHTH[3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NHmyN2dKSzVyPUmuPFYhdk1?MofXV2FPT0WU
MV-4-11NV;aNZJCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NI\lNWtKSzVyPUGwMlA{KG6PMV3TRW5ITVJ?
ESS-1MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MkLCTWM2OD1zMT6wPUBvVQ>?MYTTRW5ITVJ?
PSN1MnPNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MoTjTWM2OD1zMT6yNkBvVQ>?NXTpVJhSW0GQR1XS
MCF7NEPDU4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MnS4TWM2OD1zMT62OUBvVQ>?MofLV2FPT0WU
A427NHvHV2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NXLlZmY1UUN3ME2xNU45OSCwTR?=NFGyeXpUSU6JRWK=
NCI-H1651MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MWfJR|UxRTFzLkizJI5OMkXmV2FPT0WU
LCLC-97TM1NYHucZRPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NHzVRY1KSzVyPUGxMlg{KG6PMYfTRW5ITVJ?
DU-4475MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MXnJR|UxRTF{LkGgcm0>MU\TRW5ITVJ?
SK-LU-1MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MkSzTWM2OD1zMj61OEBvVQ>?MWXTRW5ITVJ?
NCI-H460MmToS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MkfqTWM2OD1zMj63JI5ONXy5ZpFbW0GQR1XS
A204NFjXcnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NHvPWlBKSzVyPUGyMlg5KG6PNWPZbXZ2W0GQR1XS
AGSNWTmboVpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MnnCTWM2OD1zMz6yO{BvVQ>?M4HnNXNCVkeHUh?=
NCI-H2228NVGye2hlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NH;PNXZKSzVyPUGzMlQ5KG6PM33jRXNCVkeHUh?=
HGC-27Mm\4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NW[5cmpGUUN3ME2xN{42PiCwTR?=NFf6enFUSU6JRWK=
RPMI-2650NELZW41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MYPJR|UxRTF|Lk[5JI5OMnzLV2FPT0WU
ES1MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?Mnz4TWM2OD1zMz63NkBvVQ>?NXjMVYFLW0GQR1XS
MEL-JUSOM3f3fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MU\JR|UxRTF2LkWgcm0>NHXzWW9USU6JRWK=
HT-1080NVfNXZdIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M3vud2lEPTB;MUSuPFIhdk1?NWDSSJhzW0GQR1XS
OCUB-MNHrBTVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NE\YNmxKSzVyPUG1MlE2KG6PNGfHOG5USU6JRWK=
23132-87M{X2bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MWnJR|UxRTF3LkSyJI5OM2nOS3NCVkeHUh?=
KYSE-510MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M2fz[2lEPTB;MUWuOFghdk1?NEPaeWJUSU6JRWK=
ST486MmTNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MUHJR|UxRTF3LkWzJI5OM2LjUnNCVkeHUh?=
639-VM3v1eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MXjJR|UxRTF3LkmxJI5OMmjnV2FPT0WU
COLO-679MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NWCzfVI3UUN3ME2xOU46PyCwTR?=M2PHN3NCVkeHUh?=
CTV-1M{TrOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NWq1fmoyUUN3ME2xOk4xPyCwTR?=Ml2yV2FPT0WU
BFTC-905MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NEXqb3ZKSzVyPUG2MlE5KG6PM4D6d3NCVkeHUh?=
SW954NV;JTZlmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NEHtdY5KSzVyPUG2Mlk{KG6PM1nZenNCVkeHUh?=
CAL-51MknVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NXr6VmY{UUN3ME2xO{4{OiCwTR?=NG\BRYxUSU6JRWK=
SW1710M{KyXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MnziTWM2OD1zNz60JI5OMmqwV2FPT0WU
HCC2998M3jifmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MmjCTWM2OD1zNz60OEBvVQ>?NYW2[2htW0GQR1XS
A2058NYfpc4VUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MWfJR|UxRTF5Lk[1JI5ONWr4eG1wW0GQR1XS
HCE-4M4\sSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M3XBOWlEPTB;MUiuNFchdk1?MYLTRW5ITVJ?
MEL-HONH[2fGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NVjCdmQ{UUN3ME2xPE4{KG6PMmjFV2FPT0WU
SNG-MM1PWNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NWTrUVRVUUN3ME2xPE4{OiCwTR?=NV;Be2x{W0GQR1XS
LS-123M1jmV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NU\pUpFUUUN3ME2xPE41PiCwTR?=NI\jRVRUSU6JRWK=
NALM-6M{nPTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M130XGlEPTB;MUiuOlMhdk1?MoDqV2FPT0WU
NCI-H810M2PRNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M1OzdGlEPTB;MUiuO|Yhdk1?MUHTRW5ITVJ?
YKG-1NYTPPYV7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MWDJR|UxRTF6Lke3JI5ONYSyN4RWW0GQR1XS
647-VMYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NX7oXJFqUUN3ME2xPE45OSCwTR?=MkjDV2FPT0WU
ONS-76NYHIO4s1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M4i4cGlEPTB;MUiuPVEhdk1?MXTTRW5ITVJ?
697M4[zfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NFfPO3JKSzVyPUG5MlA6KG6PMmH6V2FPT0WU
RS4-11MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NUfYPII1UUN3ME2xPU4yPCCwTR?=Mlq5V2FPT0WU
8505CMnXnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NXX4W|djUUN3ME2xPU42PiCwTR?=NIPN[49USU6JRWK=
SK-UT-1MonvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NF\sVGdKSzVyPUG5Mlk3KG6PMkXXV2FPT0WU
DOHH-2NXXpO21uT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MlHhTWM2OD1zOT65PUBvVQ>?NGX5XFVUSU6JRWK=
NCCITNVrBUJc5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M2\ZVGlEPTB;MkCuNVMhdk1?M3f6NXNCVkeHUh?=
LCLC-103HMnLtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M322d2lEPTB;MkCuOVQhdk1?NF\1eFNUSU6JRWK=
CAL-12TMmGxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NGW5cVVKSzVyPUKwMlY2KG6PMXfTRW5ITVJ?
QIMR-WILNH[5W3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NVvLUJFYUUN3ME2yNE44OiCwTR?=NV;4T3RMW0GQR1XS
SBC-5MlOxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M3z5O2lEPTB;MkCuO|Qhdk1?Mkf6V2FPT0WU
769-PNHvaeXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MXzJR|UxRTJyLke2JI5OMofJV2FPT0WU
A431M1;BdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MVjJR|UxRTJyLki3JI5OMVXTRW5ITVJ?
KE-37Mo\BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MXPJR|UxRTJzLkC1JI5OM{\CNnNCVkeHUh?=
ES8Mo\mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NGXtS5lKSzVyPUKxMlA4KG6PMWPTRW5ITVJ?
22RV1Mo[zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NUG3WYVVUUN3ME2yNU4zPCCwTR?=NEjKdJVUSU6JRWK=
LOUCYNVjIUoZST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NXPaRmJ[UUN3ME2yNU4{OiCwTR?=MmTkV2FPT0WU
J82MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?Mk[3TWM2OD1{MT6zOEBvVQ>?NUPp[YVuW0GQR1XS
MHH-ES-1NIXMfXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MUPJR|UxRTJzLkW4JI5OMVfTRW5ITVJ?
MG-63MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MkjLTWM2OD1{Mj6wPEBvVQ>?MUXTRW5ITVJ?
8-MG-BAMXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M1z6fGlEPTB;MkKuNVIhdk1?MXfTRW5ITVJ?
BPH-1NXTPWoZ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MkX5TWM2OD1{Mj6xNkBvVQ>?MYPTRW5ITVJ?
RKONWTyRXc5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M3nDWWlEPTB;MkKuNlghdk1?M{LOPXNCVkeHUh?=
HMV-IINFj5TnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MlPkTWM2OD1{Mj62JI5OMX;TRW5ITVJ?
NCI-H727NHrjRW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MojsTWM2OD1{Mj63PUBvVQ>?NWPsbmZQW0GQR1XS
MOLT-4MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MXHJR|UxRTJ{Lki2JI5OMXzTRW5ITVJ?
NCI-H2342NULV[JB7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MYPJR|UxRTJ{LkmxJI5ONE[4TFhUSU6JRWK=
MZ1-PCNITue29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NYTMWXpUUUN3ME2yN{45OSCwTR?=NW\IcJhRW0GQR1XS
TE-15M4X3OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MYHJR|UxRTJ2LkG0JI5OMUDTRW5ITVJ?
SRNVzaS3dmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MVnJR|UxRTJ2LkSxJI5ONGfjNItUSU6JRWK=
CCRF-CEMMXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NHrGO|BKSzVyPUK0MlUzKG6PMlKyV2FPT0WU
SIG-M5MnjIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NX\UepJiUUN3ME2yOU43QSCwTR?=M{PrW3NCVkeHUh?=
SK-PN-DWM3;DWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MXzJR|UxRTJ3LkeyJI5ONH\icFZUSU6JRWK=
SK-HEP-1NWTKU5NMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NFiwc5ZKSzVyPUK1Mlg3KG6PMV3TRW5ITVJ?
SW620MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MVnJR|UxRTJ4Lk[zJI5OMVrTRW5ITVJ?
HSC-2M{HtdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MVrJR|UxRTJ4Lke4JI5OM2rDRnNCVkeHUh?=
CAL-148Mny2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NEXBSY9KSzVyPUK2Mlkhdk1?MlTsV2FPT0WU
COLO-205MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MoDTTWM2OD1{Nj65PUBvVQ>?MnTUV2FPT0WU
EoL-1-cellMlvmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MUfJR|UxRTJ5Lke4JI5ONX36blF4W0GQR1XS
KYSE-150MlzuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MWjJR|UxRTJ5Lke4JI5OMk\rV2FPT0WU
G-361MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NFvj[oxKSzVyPUK4Mlg5KG6PMlz0V2FPT0WU
PANC-03-27NFHEUJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MV\JR|UxRTJ6LkG2JI5OMoTMV2FPT0WU
NCI-H2030M{DlOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NFiwWXFKSzVyPUK4MlI3KG6PMVfTRW5ITVJ?
NCI-H441M2\6SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NXfDPWdWUUN3ME2yPE41OiCwTR?=Mli5V2FPT0WU
A388NES1V3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NFWzbGxKSzVyPUK4MlQ3KG6PMkS1V2FPT0WU
BHYM{jM[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NFPZc3lKSzVyPUK4Mlg5KG6PMWXTRW5ITVJ?
KALS-1M4L6UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NEjESIxKSzVyPUK5MlM{KG6PNEHoNphUSU6JRWK=
NKM-1M{LHV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MY\JR|UxRTJ7LkS3JI5ONGHGXIFUSU6JRWK=
BB30-HNCNHLoXGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NV3JVWp4UUN3ME2yPU45PSCwTR?=NFnNR4xUSU6JRWK=
G-401M{f1[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MmLDTWM2OD1|MD6yJI5ONFPtNHlUSU6JRWK=
EW-7Mnm1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NXPUT4NMUUN3ME2zNE43OyCwTR?=NULScGJWW0GQR1XS
CANMVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NWPvV3NvUUN3ME2zNU4yOiCwTR?=NUm1e3czW0GQR1XS
M059JNYe5dFVqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M4XPcGlEPTB;M{GuN|chdk1?NH\3fW9USU6JRWK=
SK-MES-1NXS5TZR7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MknhTWM2OD1|MT61JI5OM3zieHNCVkeHUh?=
5637MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MV3JR|UxRTNzLki3JI5OM{PST3NCVkeHUh?=
MKN28M3XJXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M2H5O2lEPTB;M{GuPVEhdk1?MnSxV2FPT0WU
COR-L23MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MlPjTWM2OD1|MT65OkBvVQ>?NYnFPJRyW0GQR1XS
CAL-27NVzNTnBvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M33RRmlEPTB;M{KuOVchdk1?NHfnUVdUSU6JRWK=
CAL-62MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M2LV[GlEPTB;M{KuO|khdk1?M3PjT3NCVkeHUh?=
C-33-AMUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MVLJR|UxRTN{Lki5JI5ONXTUWHR2W0GQR1XS
RT-112NIO4XHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NXG2dZBsUUN3ME2zNk46OiCwTR?=MV7TRW5ITVJ?
KU812NUfWTm5bT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MoTjTWM2OD1|Mz6yOEBvVQ>?Mo[3V2FPT0WU
C8166MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MWTJR|UxRTN|LkOxJI5ONI[wc5VUSU6JRWK=
VA-ES-BJNXX2cGRST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M2r5bWlEPTB;M{OuN|Yhdk1?M{TFcXNCVkeHUh?=
NEC8MlLwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MY\JR|UxRTN|Lk[xJI5ONXLkRYhRW0GQR1XS
EB2M2fGcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NHvNW41KSzVyPUOzMlc{KG6PMUfTRW5ITVJ?
COLO-680NM4fBfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NWfudldQUUN3ME2zN{45PyCwTR?=MljpV2FPT0WU
IGR-1M4nV[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MoqwTWM2OD1|Mz64N{BvVQ>?M2H5TnNCVkeHUh?=
MZ2-MELNYrXRnNiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NXW5dm9MUUN3ME2zN{46OiCwTR?=MUTTRW5ITVJ?
MIA-PaCa-2Mn\wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MWnJR|UxRTN2LkK0JI5ONVrq[2s4W0GQR1XS
IMR-5MlL4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NUXvVmg1UUN3ME2zOE43QCCwTR?=MkK5V2FPT0WU
CHP-212NXXjPJZMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NH;UU|JKSzVyPUO0Mlk3KG6PNX7peFJNW0GQR1XS
CCF-STTG1NIOwZnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M{\xc2lEPTB;M{WuOUBvVQ>?NETRPGNUSU6JRWK=
SK-MEL-30NHW3XplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MXXJR|UxRTN3Lk[xJI5ONIfaO5JUSU6JRWK=
HLEMUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MnPUTWM2OD1|NT64JI5ONWnGWnMxW0GQR1XS
HOP-62MnfZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M2PzOWlEPTB;M{WuPFghdk1?NWrsO4ZKW0GQR1XS
LB1047-RCCMlKxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NXXPfG96UUN3ME2zOU46PyCwTR?=M4DXfHNCVkeHUh?=
DoTc2-4510M4P3[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MkC5TWM2OD1|Nj6yOUBvVQ>?MoHpV2FPT0WU
HT-29Mo\LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MUTJR|UxRTN4LkW3JI5OMlL4V2FPT0WU
HC-1NIDjXmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NXPNc4Y{UUN3ME2zO{4{OiCwTR?=NWSwO3RzW0GQR1XS
TE-5NFXURohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MXXJR|UxRTN5LkS4JI5OMm\mV2FPT0WU
NCI-H1299M2DVbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NUfES2l7UUN3ME2zO{42QSCwTR?=NFr1XVVUSU6JRWK=
CHL-1NVXONHlbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MoHjTWM2OD1|Nz63N{BvVQ>?MUHTRW5ITVJ?
NCI-H2122Mo\qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NVfXdJd[UUN3ME2zO{46KG6PNXvXcFJuW0GQR1XS
DELM3rTPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MkfBTWM2OD1|OD60OEBvVQ>?MYHTRW5ITVJ?
ES5MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MoLTTWM2OD1|OT6yNkBvVQ>?MnLFV2FPT0WU
CESSM365OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NFLrNFVKSzVyPUO5MlM3KG6PNWm4[|FqW0GQR1XS
NCI-H719NXrINZp7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MmfYTWM2OD1|OT62OUBvVQ>?M1;uVnNCVkeHUh?=
A3-KAWNHzxWmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NWT3[XI3UUN3ME20NE4yPCCwTR?=MmewV2FPT0WU
KP-4MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M4jzN2lEPTB;NECuO|chdk1?NFPSVJFUSU6JRWK=
NCI-H358MoXWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M3r3OWlEPTB;NEGuNFghdk1?MkTVV2FPT0WU
HCC38MkHwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MUDJR|UxRTR{LkWgcm0>NXfkd3o6W0GQR1XS
MRK-nu-1M2L4OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MkLJTWM2OD12Mz62OkBvVQ>?NYXRcHg{W0GQR1XS
NCI-H292MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M{e4TGlEPTB;NEOuO|Yhdk1?MXjTRW5ITVJ?
PA-1M1G1SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NWTjW4pyUUN3ME20OE41QCCwTR?=NYnEUWpPW0GQR1XS
CAL-85-1MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NFnre5RKSzVyPUS0MlUzKG6PM2HUUHNCVkeHUh?=
KYSE-450NHvM[FFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=Ml;XTWM2OD12ND63NUBvVQ>?M2m2WHNCVkeHUh?=
IST-MEL1M4GzSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M2HI[mlEPTB;NESuPFQhdk1?NYHMZ2o3W0GQR1XS
Ca-SkiM{HrdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M2fVU2lEPTB;NESuPFQhdk1?NWi3dWVZW0GQR1XS
OCI-AML2MnjOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M4\FVWlEPTB;NEWuNFUhdk1?MV;TRW5ITVJ?
NUGC-3NILoXpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MlznTWM2OD12NT6yJI5OMoDiV2FPT0WU
HOSNEHhR25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NYr6XYhEUUN3ME20OU4zQSCwTR?=MUnTRW5ITVJ?
NB1NYfDbXRMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MoTHTWM2OD12NT65PUBvVQ>?MUTTRW5ITVJ?
A253NXXyZWNCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NFHv[XRKSzVyPUS2MlEzKG6PNE\QW3FUSU6JRWK=
NCI-H209NIn0dJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=Mmi3TWM2OD12OD63N{BvVQ>?MVjTRW5ITVJ?
MC-CARMmDGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MkfLTWM2OD12OD63OEBvVQ>?M1jMbHNCVkeHUh?=
NCI-H661M3nmT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MlzwTWM2OD12OT6wN{BvVQ>?M1exbnNCVkeHUh?=
SF295NWPlUHAxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MoC0TWM2OD12OT6wPEBvVQ>?M4n2[3NCVkeHUh?=
GP5dNYLmUFF[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NWHaVIp1UUN3ME20PU4yOiCwTR?=M3:1d3NCVkeHUh?=
P12-ICHIKAWANGjkbI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M3riSmlEPTB;NEmuNlchdk1?MlfSV2FPT0WU
ACHNNHzwdnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M3PxSWlEPTB;NEmuN|Qhdk1?M{frT3NCVkeHUh?=
NCI-H2087NWOwRVViT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MYTJR|UxRTR7LkSyJI5OMmHUV2FPT0WU
SW48NGD0W3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NF7nOHJKSzVyPUS5MlczKG6PMW\TRW5ITVJ?
NCI-H526Mlf1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NFLyRWdKSzVyPUS5Mlk3KG6PM4\ucnNCVkeHUh?=
Ca9-22MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NYrINpR1UUN3ME21NE4xPyCwTR?=NFvtOnFUSU6JRWK=
SK-OV-3NYPMfXdNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=Mnv5TWM2OD13MD6xNkBvVQ>?MlHmV2FPT0WU
KYSE-140MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NYe4VGxpUUN3ME21NE41OiCwTR?=NVr3dZlOW0GQR1XS
BE-13M{njUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NITvdYVKSzVyPUWxMlAzKG6PNV;vSnR3W0GQR1XS
ES7M17sTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MX7JR|UxRTVzLkSgcm0>M2PJeHNCVkeHUh?=
IM-9NHPFWmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M{HsdmlEPTB;NUGuOFMhdk1?MX3TRW5ITVJ?
A101DMmDuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NIizcXZKSzVyPUWxMlQ5KG6PM2nXUHNCVkeHUh?=
CAPAN-1M2\rUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NF;le4hKSzVyPUWxMlc3KG6PNInReppUSU6JRWK=
NCI-H2009MnvtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NVm0[3FwUUN3ME21NU44PiCwTR?=MVzTRW5ITVJ?
NCI-H522NEPCTXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M37EXmlEPTB;NUGuPVMhdk1?MXLTRW5ITVJ?
HuP-T4NIHPeG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NXS3d5p4UUN3ME21Nk4zOiCwTR?=M3myenNCVkeHUh?=
BCPAPNHT3RmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MmjLTWM2OD13Mj61JI5ONGLuRm5USU6JRWK=
NCI-H1734NVXWdok1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MlnqTWM2OD13MzDuUS=>NGHnOZdUSU6JRWK=
SK-LMS-1NUP6WlR7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NI\DS5NKSzVyPUWzMlIzKG6PMV\TRW5ITVJ?
CGTH-W-1NImzTZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M3XBPGlEPTB;NUOuOFYhdk1?Moq3V2FPT0WU
RPMI-8402MkLsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?Ml\iTWM2OD13Mz64OkBvVQ>?MmXEV2FPT0WU
Calu-3MoTtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NWnFfVVyUUN3ME21OU46QCCwTR?=MkDwV2FPT0WU
COR-L279NUXNRYRQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MXnJR|UxRTV4Lkm1JI5OM3zuVnNCVkeHUh?=
T84NWjJOZk6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=Ml3nTWM2OD13Nz6wOkBvVQ>?NXHLbYt[W0GQR1XS
P30-OHKNIjFSotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M3fVdmlEPTB;NUeuOVchdk1?NE\JfXZUSU6JRWK=
CHP-126M4XRNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M2DMeGlEPTB;NUmuNlQhdk1?NEXLb4FUSU6JRWK=
KYSE-180NFTYco5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M3nxUGlEPTB;NUmuO|Uhdk1?NXnaWZlDW0GQR1XS
CAMGMVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NUPEV5FJUUN3ME21PU46PiCwTR?=M1XtOHNCVkeHUh?=
EW-1MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MlPlTWM2OD14MT6zOUBvVQ>?MVTTRW5ITVJ?
OVCAR-8NIXVVJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MVTJR|UxRTZzLkmyJI5OMX3TRW5ITVJ?
HL-60NET3WGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M17ObGlEPTB;NkKuOVYhdk1?NXTzWmtKW0GQR1XS
8305CMV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NWPhNm04UUN3ME22N{4yOiCwTR?=Mlu1V2FPT0WU
IA-LMMofsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NX7jTYJ5UUN3ME22N{42PCCwTR?=M2\Db3NCVkeHUh?=
HCC2157NYjtRnoyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NX;o[HdIUUN3ME22N{46PSCwTR?=M2\kU3NCVkeHUh?=
CTB-1M4jKfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NHLCcpZKSzVyPU[0NFE6KG6PMnrLV2FPT0WU
NCI-H1437MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MU\JR|UxRTZ2Lk[0JI5ONYrKPJM{W0GQR1XS
U251Ml;sS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NGjyeZlKSzVyPU[0Mlg6KG6PNVXvXnBqW0GQR1XS
ALL-PONFj0SWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NYPJTY9kUUN3ME22OU4xOyCwTR?=MYrTRW5ITVJ?
NCI-SNU-1MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NITWRoRKSzVyPU[1Mlg3KG6PMmDUV2FPT0WU
RPMI-6666MoPkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M1;CVmlEPTB;NkWuPVkhdk1?NVqxSoxwW0GQR1XS
DBTRG-05MGM2S4Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M2H2PGlEPTB;NkeuNVEhdk1?Mn[yV2FPT0WU
PF-382MkLxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NYfPN|ZmUUN3ME22O{4yPyCwTR?=M3j4c3NCVkeHUh?=
GT3TKBMUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MXnJR|UxRTZ5LkG5JI5OMoi1V2FPT0WU
SCC-3NIDm[4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NYnWdGJLUUN3ME22O{4zQCCwTR?=NID5eXRUSU6JRWK=
LU-134-AM4\vXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MXHJR|UxRTZ5Lk[4JI5ONGH2PGNUSU6JRWK=
CAL-33M4G1eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MVzJR|UxRTZ5Lki3JI5OMVLTRW5ITVJ?
MC-IXCMXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MUPJR|UxRTZ5Lkmgcm0>NFm3OHBUSU6JRWK=
CPC-NMUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?Ml7DTWM2OD14OD60JI5OM3voNnNCVkeHUh?=
A2780MkDHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NX\LOWl6UUN3ME22PE44QSCwTR?=NIfld4hUSU6JRWK=
DaudiM4DCPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M1zXSWlEPTB;NkiuPVYhdk1?MnrjV2FPT0WU
GI-1NHnsVmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M3j4dGlEPTB;NkmuOlUhdk1?NIXORldUSU6JRWK=
SW962MlniS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MWPJR|UxRTZ7Lkm1JI5OMVnTRW5ITVJ?
MFE-296MmjJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NFvXVYFKSzVyPUewMlQ6KG6PMUjTRW5ITVJ?
H4NEiwbW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MYLJR|UxRTdzLkW2JI5ONI[4NXpUSU6JRWK=
AN3-CANXfWbGJ7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M1;UNWlEPTB;N{KuN|Ihdk1?NYXYNHhyW0GQR1XS
HCC1599NGTvTnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MmHpTWM2OD15Mj61OEBvVQ>?MVPTRW5ITVJ?
HuCCT1Mnz1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MXXJR|UxRTd{LkmzJI5OMXfTRW5ITVJ?
Calu-1MlrGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MWfJR|UxRTd|Lk[gcm0>M4PhdHNCVkeHUh?=
DU-145MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NVLjUGhSUUN3ME23N{44OyCwTR?=M1;OeHNCVkeHUh?=
IST-SL2MlPuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NWe5[nJzUUN3ME23N{45OSCwTR?=MmLmV2FPT0WU
HSC-3NHnNbXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NVzRUZJXUUN3ME23OE42OyCwTR?=NWfMOVU6W0GQR1XS
HCC1806NGD0TGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MoiwTWM2OD15ND65OkBvVQ>?NFTsWmdUSU6JRWK=
VM-CUB-1NUnP[Gs2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MmLMTWM2OD15NT6zOkBvVQ>?Ml;SV2FPT0WU
HSC-4M2DITmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NI\USoFKSzVyPUe1Mlc3KG6PMYXTRW5ITVJ?
NH-12MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NGr1VJdKSzVyPUe2JI5OMlzZV2FPT0WU
MDA-MB-468MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NVXPbJlyUUN3ME23Ok4yQCCwTR?=MULTRW5ITVJ?
TURMXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NV\6XJgyUUN3ME23Ok4{OiCwTR?=M3WxSHNCVkeHUh?=
TE-1MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M{jqV2lEPTB;N{[uN|Uhdk1?NIr3[FFUSU6JRWK=
CMKNX\N[mZLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NVKwUVN1UUN3ME23O{41OiCwTR?=MmjnV2FPT0WU
LB996-RCCNVG5ZYtLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NWn3[INZUUN3ME23PE41PSCwTR?=M4TxXXNCVkeHUh?=
NCI-H1650M3H5UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NYjZcWZsUUN3ME23PE43OiCwTR?=MVzTRW5ITVJ?
DMS-273Mkj6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NXuy[pV5UUN3ME23PE46KG6PNF\KendUSU6JRWK=
NOS-1M3PteGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MojuTWM2OD15OT6xOEBvVQ>?MWrTRW5ITVJ?
NB69MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M2ruVmlEPTB;N{muNkBvVQ>?M2fWV3NCVkeHUh?=
SUP-T1MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M{nSfGlEPTB;N{muO|Ihdk1?MXrTRW5ITVJ?
A172MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MWPJR|UxRThyLkW1JI5OMkj4V2FPT0WU
TE-12MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MY\JR|UxRThzLkC2JI5OMUfTRW5ITVJ?
MKN45NU[4[oI3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NGXoUJFKSzVyPUixMlUyKG6PMVrTRW5ITVJ?
LoVoMWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MVPJR|UxRThzLkiyJI5OM2jKUHNCVkeHUh?=
SW1573MlzWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NGX1PFVKSzVyPUiyMlgyKG6PNI\VZldUSU6JRWK=
ETK-1NGrmOotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MonQTWM2OD16Mz6wNUBvVQ>?MW\TRW5ITVJ?
ABC-1NWTlNnN1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NI\ISI9KSzVyPUizMlQ2KG6PMXrTRW5ITVJ?
COLO-668M1vJRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NX;jWm9CUUN3ME24OE41PyCwTR?=NEi5VJdUSU6JRWK=
UM-UC-3M{DjeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MnLsTWM2OD16Nj6wNkBvVQ>?MXHTRW5ITVJ?
BC-1Mn3RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MWPJR|UxRTh4Lke2JI5OMoS0V2FPT0WU
PANC-10-05NVPjVllVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MWPJR|UxRTh6LkS1JI5ONHzJ[XFUSU6JRWK=
ES3MnL6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NEO1Z3VKSzVyPUi5MlQ5KG6PM2rYTHNCVkeHUh?=
TE-441-TNHOwN21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MkTTTWM2OD16OT64NkBvVQ>?MWTTRW5ITVJ?
KM-H2M3nybmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MXfJR|UxRTlyLk[4JI5OMoLuV2FPT0WU
SH-4Mmi0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NYLjSlh1UUN3ME25Nk4yOSCwTR?=M1;XbXNCVkeHUh?=
SF268M2f3dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NYHC[lVUUUN3ME25Nk41OiCwTR?=MkPKV2FPT0WU
VMRC-RCZMXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MXnJR|UxRTl|LkK2JI5OMYXTRW5ITVJ?
GI-ME-NMlX1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M3X4NGlEPTB;OUOuN|Mhdk1?Mn;KV2FPT0WU
JEG-3M2jGdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NFnWV3VKSzVyPUm1MlEzKG6PMl7VV2FPT0WU
J-RT3-T3-5NW\KNoJwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MUTJR|UxRTl4LkOxJI5ONHKxSnVUSU6JRWK=
K5NH3uXZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=Mmi0TWM2OD17Nj65JI5OMnLoV2FPT0WU
EFO-27NV:5RVJLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NEjMZ5hKSzVyPUm3MlQ1KG6PNV7FZmhvW0GQR1XS
SW1783NXHQOXpFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NWDu[Y0xUUN3ME25O{46QSCwTR?=MYjTRW5ITVJ?
CAL-39MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M{TGcmlEPTB;OUiuNlQhdk1?NIHWRnpUSU6JRWK=
LS-441NNWn4PVdmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MlvlTWM2OD17OT6wOkBvVQ>?MoPTV2FPT0WU
G-402M{nCTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M3PLb2lEPTB;OUmuNFkhdk1?MmXrV2FPT0WU
MES-SAMYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M{jOd2lEPTB;OUmuOVMhdk1?NFvP[3dUSU6JRWK=
FADUM{DlT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NYnhUYtyUUN3ME2xNFIvOThibl2=MV3TRW5ITVJ?
DJM-1M2\2c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NXzTbJVkUUN3ME2xNFIvOjVibl2=M2DhTXNCVkeHUh?=
SU-DHL-1NEfOV5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M{OxfWlEPTB;MUCyMlUhdk1?MUDTRW5ITVJ?
KYSE-410MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NUnOTZVXUUN3ME2xNFMvPDZibl2=MkC0V2FPT0WU
NCI-H1618M3O0[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7M3\4eWlEPTB;MUC0MlM2KG6PNYTVXohlW0GQR1XS
AU565Mn;CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NW\lb3B{UUN3ME2xNFQvPTFibl2=M3jkfHNCVkeHUh?=
SF126NV\pcVZ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M1;4VGlEPTB;MUC0MlU5KG6PMYrTRW5ITVJ?
MMAC-SFNV:3ZmZrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MXfJR|UxRTFyNj60PEBvVQ>?NXvIVlhDW0GQR1XS
ChaGo-K-1NF3NR|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NIn1XGlKSzVyPUGwO{46PSCwTR?=MUHTRW5ITVJ?
NCI-H596M3zQeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NH\DS5ZKSzVyPUGwPE4xOSCwTR?=NIixeHpUSU6JRWK=
LXF-289MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MXPJR|UxRTFyOT6yOEBvVQ>?M1nvc3NCVkeHUh?=
HCC1569MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MYDJR|UxRTFyOT6zOEBvVQ>?M37NPXNCVkeHUh?=
NCI-H2170NEDMVo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NVzBOYR2UUN3ME2xNFkvQTJibl2=MWnTRW5ITVJ?
ARH-77MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MUHJR|UxRTFyOT65PUBvVQ>?NGTsSW1USU6JRWK=
BOKUM1nqbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NEjaOoxKSzVyPUGxNE45PyCwTR?=NYHyZmVoW0GQR1XS
SJSA-1MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M{fa[WlEPTB;MUGxMlA2KG6PNYPBWGpVW0GQR1XS
SW626MoXOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M{fxcmlEPTB;MUGxMlcyKG6PNXXwfGppW0GQR1XS
EHEBNGLa[pNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NX6zbJNJUUN3ME2xNVIvPTlibl2=NULGRWgzW0GQR1XS
TE-10MkW1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M3zqfmlEPTB;MUGyMlY5KG6PM2\UdHNCVkeHUh?=
MZ7-melNV7xT21UT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M4XKN2lEPTB;MUGyMlg1KG6PNVPpUVc5W0GQR1XS
SASM1TZNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NEDkPGNKSzVyPUGxOE41PSCwTR?=MYnTRW5ITVJ?
TK10NXnjNmZ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=Mkf2TWM2OD1zMUSuOkBvVQ>?NH:zNW5USU6JRWK=
SW13M{PkZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MWPJR|UxRTFzNT6yOkBvVQ>?MU\TRW5ITVJ?
HCC1937NIfjZWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MV\JR|UxRTFzNT64OEBvVQ>?NX3jb4tQW0GQR1XS
SK-NEP-1M{\4cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NX\XW2RVUUN3ME2xNVYvOjZibl2=M37EOHNCVkeHUh?=
OVCAR-5MojKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M33nU2lEPTB;MUG2MlgyKG6PMV3TRW5ITVJ?
SW837M2nBcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MoiyTWM2OD1zMUeuPVUhdk1?NES1N5dUSU6JRWK=
BFTC-909MnXLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NEXmXXNKSzVyPUGxPE41QCCwTR?=NHXOXGlUSU6JRWK=
SW872MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NHHtZo5KSzVyPUGyNE45OSCwTR?=MYXTRW5ITVJ?
SF539NWHEXIh2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MW\JR|UxRTF{MT63NkBvVQ>?Moi5V2FPT0WU
MLMAM4LJemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MWjJR|UxRTF{Mj6wPEBvVQ>?MWLTRW5ITVJ?
BL-41NULEZWt{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NYraeJozUUN3ME2xNlIvOjJibl2=MUjTRW5ITVJ?
LB647-SCLCNXq5U4M5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MnHTTWM2OD1zMkOuN|Uhdk1?Mlv6V2FPT0WU
NCI-H1703MnvaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NVXycWxSUUN3ME2xNlYvPDJibl2=NF73eXFUSU6JRWK=
KURAMOCHINX7tc4huT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MkXWTWM2OD1zMk[uO|Yhdk1?NIjofnhUSU6JRWK=
ATN-1MoLCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MUXJR|UxRTF{Nz63JI5ONYPiSlFOW0GQR1XS
SK-CO-1Mmr0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M{e1UmlEPTB;MUK5MlIyKG6PNYW4bJZYW0GQR1XS
RPMI-7951M4j0V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NHTBUpRKSzVyPUGzNE4yPCCwTR?=NWLqS5Z2W0GQR1XS
NCI-H1648M4nqRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NW\lUmdLUUN3ME2xN|EvQTRibl2=NF3QWJBUSU6JRWK=
NCI-H64NVXXS|BVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MoX0TWM2OD1zM{KuOlUhdk1?NFzrV5JUSU6JRWK=
HT-3M4XDbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M4DQPWlEPTB;MUOzMlA1KG6PMl\yV2FPT0WU
NCI-H1770M1nKZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MkX4TWM2OD1zM{OuNlEhdk1?MULTRW5ITVJ?
NB13M1ft[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M4\tdWlEPTB;MUO0MlU2KG6PMorjV2FPT0WU
NCI-H747Mn23S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MV7JR|UxRTF|NT6wNkBvVQ>?M{\CdnNCVkeHUh?=
ML-2M3nBWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MYDJR|UxRTF|NT6xOkBvVQ>?MVzTRW5ITVJ?
CA46NV\wXHBLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NHXwco9KSzVyPUGzOk45QCCwTR?=MVPTRW5ITVJ?
ES6NYXzSoNiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NYHSXFhDUUN3ME2xN|cvOTJibl2=MXHTRW5ITVJ?
JiyoyeP-2003MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NGDXe3NKSzVyPUGzO{45KG6PNGOxe2dUSU6JRWK=
NMC-G1MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M3;nTGlEPTB;MUO5MlE{KG6PNI\vV5lUSU6JRWK=
U-698-MMUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MknjTWM2OD1zM{muOUBvVQ>?NH\yXGFUSU6JRWK=
LU-99AM3\xfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MkDRTWM2OD1zNE[uOVUhdk1?NVPPZ4JqW0GQR1XS
NCI-H748MmL1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NHf5dWVKSzVyPUG0O{4{OSCwTR?=NEDRVW5USU6JRWK=
SK-MEL-3NEfFUmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NE\BW5lKSzVyPUG0O{43OSCwTR?=NF;uSmpUSU6JRWK=
SNB75MnPRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NEfQdIVKSzVyPUG0PE43PSCwTR?=M1HkWXNCVkeHUh?=
BB65-RCCMUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M1r6bGlEPTB;MUS5MlMyKG6PMWjTRW5ITVJ?
NCI-H1355M4DSeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NVHwfoVrUUN3ME2xOVIvOjRibl2=NFrZVopUSU6JRWK=
SCC-25NGn0dGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MVXJR|UxRTF3Mz63N{BvVQ>?NGjDPI5USU6JRWK=
OAW-42NH7zRlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NYTIc5JRUUN3ME2xOVMvQDRibl2=NELOeIJUSU6JRWK=
MONO-MAC-6NH3JSXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MVzJR|UxRTF3ND6zOkBvVQ>?MVLTRW5ITVJ?
WSU-NHLNXvMTWJ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NW\je4lIUUN3ME2xOVQvPThibl2=MmLNV2FPT0WU
SNU-423MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MVXJR|UxRTF3NT6zOEBvVQ>?M33vN3NCVkeHUh?=
SBC-1M3LsOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NXzS[4ViUUN3ME2xOVYvPCCwTR?=M4nVSHNCVkeHUh?=
OVCAR-4NXvMZmVoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NG\mb|NKSzVyPUG1Ok44QCCwTR?=MUTTRW5ITVJ?
NCI-H2347Mn\zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M3m4TmlEPTB;MUW4MlM1KG6PMoS5V2FPT0WU
CAMA-1MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NH;KTHJKSzVyPUG1PU4{OyCwTR?=MWPTRW5ITVJ?
GDM-1NGTFcFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MYjJR|UxRTF3OT63JI5OMXHTRW5ITVJ?
KNS-81-FDNV\VdoJ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M3SyRWlEPTB;MU[wMlMzKG6PMo\zV2FPT0WU
no-10MnXCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NGP1ZpdKSzVyPUG2NE4{QCCwTR?=NIDHXFFUSU6JRWK=
NCI-H2052M3jYfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MWfJR|UxRTF4MD60O{BvVQ>?NXj0VI1mW0GQR1XS
DBM2\aeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M3HCTWlEPTB;MU[xMlcyKG6PNY\GdIlwW0GQR1XS
A4-FukMlfYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MkDtTWM2OD1zNkKuOFghdk1?MojCV2FPT0WU
HCE-TNUH4TJlWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M4q5eWlEPTB;MU[0Mlg4KG6PMYrTRW5ITVJ?
HuP-T3MmrkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NFH5NphKSzVyPUG2OU42PSCwTR?=NEf3cWVUSU6JRWK=
BC-3M3LZfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NHniS3BKSzVyPUG2OU45PiCwTR?=M4HkZnNCVkeHUh?=
RVH-421M2\C[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M3LGOWlEPTB;MU[5MlE{KG6PNGPpNlhUSU6JRWK=
COLO-800MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M4jqNWlEPTB;MUexMlghdk1?NYTKeGNEW0GQR1XS
OMC-1NWLuNGdjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NFLPO4xKSzVyPUG3Nk4yPyCwTR?=NVvYZ4NoW0GQR1XS
SJRH30NFfNe3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NXS2fpVIUUN3ME2xO|IvQTRibl2=M1rZWHNCVkeHUh?=
HELNU\WUJYyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M3HUZmlEPTB;MUe1MlE2KG6PNYfOWo1XW0GQR1XS
KLENH7EcmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MWPJR|UxRTF5NT60O{BvVQ>?MWXTRW5ITVJ?
MEG-01NVvwVJdWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M2P4cmlEPTB;MUe2MlYhdk1?MnflV2FPT0WU
OAW-28M1vKbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MmTHTWM2OD1zN{iuPFQhdk1?NFTRV49USU6JRWK=
RDMXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MYLJR|UxRTF6MD6xJI5ONUTL[2lPW0GQR1XS
HCC2218MoPIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MnH6TWM2OD1zOEGuOlYhdk1?MlHiV2FPT0WU
OS-RC-2MnHRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NVjvdnFxUUN3ME2xPFIvPDlibl2=MWXTRW5ITVJ?
HEC-1NF32fXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M4HGdGlEPTB;MUiyMlg{KG6PM{DI[nNCVkeHUh?=
SCC-4MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MmfKTWM2OD1zOEOuO|Ehdk1?MUXTRW5ITVJ?
ME-180NXK1[IdNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MVHJR|UxRTF6Nj6wPEBvVQ>?NYLpZ2x6W0GQR1XS
NB10MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MmKyTWM2OD1zOEiuNFkhdk1?M4HJV3NCVkeHUh?=
SCC-15M4jtbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M3\MXWlEPTB;MUi4MlI1KG6PNWqzV4JZW0GQR1XS
COR-L105MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NY\VcIRoUUN3ME2xPFgvQTJibl2=NUnac|NiW0GQR1XS
HT-1376NWDReXYxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MlLyTWM2OD1zOEmuNFEhdk1?MV3TRW5ITVJ?
RPMI-8866NGXse2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NY\ObpRUUUN3ME2xPVIvOTNibl2=M3;Be3NCVkeHUh?=
NCI-H2126MoO0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MWnJR|UxRTF7Mj6yJI5OMnnrV2FPT0WU
KARPAS-422Mn7LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?Mn[2TWM2OD1zOUOuOFEhdk1?M2HxNnNCVkeHUh?=
COLO-741M4jldWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M1fGZ2lEPTB;MUm0MlU5KG6PM{\1UXNCVkeHUh?=
IPC-298MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NXGzZ5BiUUN3ME2xPVYvOjFibl2=MXzTRW5ITVJ?
OE19M4nyfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7Ml7CTWM2OD1{MECuNVghdk1?NUnKepNGW0GQR1XS
NCI-H1694MoT3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MkezTWM2OD1{MECuNlYhdk1?NHmyOoVUSU6JRWK=
SW1990MkXRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NF3VSJNKSzVyPUKwNU46KG6PNXjnVmdqW0GQR1XS
LNCaP-Clone-FGCMkLRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NIrFWJVKSzVyPUKwOE41PyCwTR?=NUP5UHRqW0GQR1XS
LB831-BLCNGn0OHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M2fBfGlEPTB;MkC2MlI2KG6PNWTldpZEW0GQR1XS
HCT-116MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MVTJR|UxRTJyNz6zPUBvVQ>?M3uybnNCVkeHUh?=
BxPC-3NImwR21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NI\kclJKSzVyPUKxNE46PiCwTR?=MlrhV2FPT0WU
HT-1197M17xV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7M1\mZWlEPTB;MkGyMlU5KG6PMkPkV2FPT0WU
GB-1M{LGPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NUDVfI5NUUN3ME2yNVIvPzNibl2=NFPLUndUSU6JRWK=
RPMI-8226MmjXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MV3JR|UxRTJzMz6zO{BvVQ>?NGXaV5VUSU6JRWK=
L-540NYeyWlV3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M4PQ[2lEPTB;MkGzMlQ6KG6PMkLRV2FPT0WU
NCI-H1882NI[3TFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MYDJR|UxRTJzNTDuUS=>NF7NfotUSU6JRWK=
A673NGfmfWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M3\OemlEPTB;MkG1Mlc6KG6PMnjpV2FPT0WU
NCI-H650MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MXHJR|UxRTJzNz62NUBvVQ>?MmH2V2FPT0WU
KM12NIm2coRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NX6xcZRjUUN3ME2yNVgvOTVibl2=NXrPSVU2W0GQR1XS
KP-N-YSM3zDVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MX3JR|UxRTJzOD60JI5OM2rJWHNCVkeHUh?=
COLO-684MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?Mk\QTWM2OD1{MUmuO|khdk1?NX2ySZpoW0GQR1XS
MHH-NB-11NIf1XFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M{m2R2lEPTB;MkKwMlIzKG6PMVzTRW5ITVJ?
HO-1-N-1NVXseGpVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M3XUXWlEPTB;MkKyMlg{KG6PMWTTRW5ITVJ?
NOMO-1NETsbopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M3LpNGlEPTB;MkK0MlQ{KG6PMWDTRW5ITVJ?
KYSE-70MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NX;PSpd{UUN3ME2yNlQvPjZibl2=Mmf5V2FPT0WU
NCI-H838NGHte|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=Mlm3TWM2OD1{MkSuO|Mhdk1?NF3mU2ZUSU6JRWK=
NYMXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MY\JR|UxRTJ{OD60PUBvVQ>?NUjGZXNTW0GQR1XS
NCI-H2196Ml3TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MWnJR|UxRTJ{OT6xOUBvVQ>?MYPTRW5ITVJ?
FTC-133NX\pR4doT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NUDhPWxCUUN3ME2yNlkvOzdibl2=MmXrV2FPT0WU
MHH-PREB-1NGLzRZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NUKxPXFxUUN3ME2yNlkvQDJibl2=NELDeYJUSU6JRWK=
SK-MEL-2NGLySlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NV\uTHQ2UUN3ME2yN|AvOyCwTR?=NFXXUYtUSU6JRWK=
Detroit562M2nLR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7M2PwT2lEPTB;MkOwMlczKG6PM2jTSHNCVkeHUh?=
NCI-H2405MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NEDZZmJKSzVyPUKzOE4yKG6PNHTxeVRUSU6JRWK=
NCI-H2081M1rBRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MlP3TWM2OD1{M{SuNlchdk1?NX\ZWGdyW0GQR1XS
LB2241-RCCMnn3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MULJR|UxRTJ|NT6xNUBvVQ>?NWPTPGxtW0GQR1XS
SNU-387MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MkXKTWM2OD1{M{[uNFghdk1?Ml32V2FPT0WU
PC-14NYGwVIJbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NULoWmFVUUN3ME2yN|YvOTJibl2=NFvU[4RUSU6JRWK=
CAS-1NX;lbFY3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M2n4OmlEPTB;MkO4MlMyKG6PNGTkNXRUSU6JRWK=
TE-11M1HXcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MXvJR|UxRTJ2MD64PEBvVQ>?MX\TRW5ITVJ?
LC4-1MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NV3aNIcyUUN3ME2yOFAvQDlibl2=NX7HR2pCW0GQR1XS
HHM4KwUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MofQTWM2OD1{NEGuOFYhdk1?MY\TRW5ITVJ?
JVM-2MkjPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M2j4cWlEPTB;MkSyMlE4KG6PMm\zV2FPT0WU
KNS-42Ml7vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M{fETWlEPTB;MkSyMlY4KG6PNFr0cnVUSU6JRWK=
T-24NXTZepcyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NGTXSHZKSzVyPUK0OU41QCCwTR?=NEe2ZpJUSU6JRWK=
D-392MGM{PMdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MnPiTWM2OD1{NEiuOUBvVQ>?MWPTRW5ITVJ?
KOSC-2NWC5U4VST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MX\JR|UxRTJ2OD63NUBvVQ>?M1HCXHNCVkeHUh?=
D-283MEDNEnhcXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MlzGTWM2OD1{NUCuNVMhdk1?M3LEb3NCVkeHUh?=
BV-173M4jM[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M1v0bGlEPTB;MkWwMlc4KG6PNV;N[4V7W0GQR1XS
EW-18MkXqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MVXJR|UxRTJ3MD65JI5ONFvaPJFUSU6JRWK=
MS-1NVfXbJNVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MormTWM2OD1{NUKuOVMhdk1?M4nNVHNCVkeHUh?=
Calu-6NELnfXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NIDxNFVKSzVyPUK1N{42PSCwTR?=NITnd|VUSU6JRWK=
GR-STM4jXSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NGrkWJpKSzVyPUK1OU41OiCwTR?=NV\sXHFlW0GQR1XS
GAKNX3rR5dFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MnXITWM2OD1{NU[uPVEhdk1?M4nzeXNCVkeHUh?=
TE-9M{fW[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NFjJTItKSzVyPUK1O{41PyCwTR?=MVLTRW5ITVJ?
HuH-7MnfjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M{i3OWlEPTB;MkW4MlQ1KG6PMoHGV2FPT0WU
KYSE-520NHTZT4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=Ml[1TWM2OD1{NkCuO|chdk1?MnqxV2FPT0WU
NCI-H520NIO4cIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MXrJR|UxRTJ4Nj62NUBvVQ>?MmTNV2FPT0WU
HD-MY-ZM{W4ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NYj0bGh3UUN3ME2yO|IvPzlibl2=MU\TRW5ITVJ?
SW756NEHNXG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MXfJR|UxRTJ5ND63PEBvVQ>?MYXTRW5ITVJ?
NB12Ml\GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NHHifYVKSzVyPUK3O{4yOiCwTR?=MW\TRW5ITVJ?
EW-3NWfBcWU{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NUPD[2YzUUN3ME2yO|kvQDlibl2=M1n3PHNCVkeHUh?=
AM-38MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?Ml7zTWM2OD1{OEGuOVIhdk1?MlvjV2FPT0WU
NCI-H23Mn23S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MVPJR|UxRTJ6Mz65NkBvVQ>?MWfTRW5ITVJ?
GOTOMXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NXXYVHZwUUN3ME2yPFUvPTZibl2=MXfTRW5ITVJ?
NCI-H1693NH7KfmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M3XTOmlEPTB;MkmwMlMzKG6PMVnTRW5ITVJ?
MOLT-16MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MVfJR|UxRTJ7MD61JI5OM4fDcHNCVkeHUh?=
HOP-92MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?Mo\OTWM2OD1{OUCuO{BvVQ>?M{K3TnNCVkeHUh?=
MDA-MB-361NX3OeFhVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NF6yfJlKSzVyPUK5Nk43PSCwTR?=MkPSV2FPT0WU
Ramos-2G6-4C10MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NWLwXI5WUUN3ME2yPVQvPTVibl2=M2jt[nNCVkeHUh?=
CAL-54M3rUVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MlnTTWM2OD1|MECuO|Mhdk1?MljZV2FPT0WU
D-263MGNYjxZ4dtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M4C0c2lEPTB;M{C1MlUzKG6PMWHTRW5ITVJ?
SKG-IIIaM{XBV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7M3i4RWlEPTB;M{GxMlE1KG6PMl[yV2FPT0WU
HAL-01M4rh[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NHKyTlVKSzVyPUOxN{41PCCwTR?=NV\sdWNoW0GQR1XS
LAN-6NILiO|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M17TNGlEPTB;M{G1MlEyKG6PNUTkPYpVW0GQR1XS
NCI-H1304MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MkTrTWM2OD1|MkGuNVchdk1?NITNWmhUSU6JRWK=
no-11NEG5fXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NGrSXmhKSzVyPUOyNU43PCCwTR?=MWfTRW5ITVJ?
IST-MES1MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NVftXm95UUN3ME2zNlMvOzVibl2=MnzwV2FPT0WU
L-363M1S3S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7Mo\mTWM2OD1|MkSuOFMhdk1?MlzDV2FPT0WU
EM-2NYnGSG9qT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=Mn7pTWM2OD1|MkWuOFEhdk1?NF3vc2FUSU6JRWK=
DV-90M4HEdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MnTZTWM2OD1|MkmuOFUhdk1?MXPTRW5ITVJ?
Saos-2MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M{H2cWlEPTB;M{K5Mlk1KG6PM3nhNnNCVkeHUh?=
UMC-11MljFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MkX3TWM2OD1|M{GuNlghdk1?M1PpNnNCVkeHUh?=
RajiMn7MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M{jW[2lEPTB;M{O0MlY1KG6PMUDTRW5ITVJ?
RXF393NUmzOo15T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MmPVTWM2OD1|M{WuOFMhdk1?NX\XO5hDW0GQR1XS
EW-11M1r2VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MlvTTWM2OD1|NEGuOVYhdk1?MXHTRW5ITVJ?
BL-70NFj0VpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NGTkOHFKSzVyPUO0Nk4xOSCwTR?=NU\0OoZ1W0GQR1XS
LB373-MEL-DMXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MnT3TWM2OD1|NESuOlQhdk1?MWTTRW5ITVJ?
LU-139M{LUbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MVXJR|UxRTN2ND65NkBvVQ>?MlLIV2FPT0WU
U-87-MGM4KxO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7M4rHZWlEPTB;M{S2MlA1KG6PMoPQV2FPT0WU
LU-65MojrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MVHJR|UxRTN2Nj60JI5OMoW2V2FPT0WU
U031M3vKVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NXnUeVd[UUN3ME2zOVMvQDdibl2=NInpOldUSU6JRWK=
HNNVPi[mt1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NYXZXHZsUUN3ME2zOVQvOjdibl2=Ml7wV2FPT0WU
MHH-CAL-2MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MVfJR|UxRTN3OT6yNUBvVQ>?M4C4cnNCVkeHUh?=
NCI-H510ANH;SOmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MUHJR|UxRTN3OT61PUBvVQ>?NVnuU3pOW0GQR1XS
NB5NXyxPZN6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NVHWOGt3UUN3ME2zOVkvQDFibl2=MUXTRW5ITVJ?
KG-1NEDkO5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=Mn;lTWM2OD1|NkGuOVIhdk1?MnzlV2FPT0WU
EFO-21MnvVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MlH0TWM2OD1|NkGuPFUhdk1?NWHwdItQW0GQR1XS
UACC-257MkHQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MnnaTWM2OD1|NkKuNFUhdk1?Mmj6V2FPT0WU
SW1417MkSzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M4HxbmlEPTB;M{[zMlI{KG6PMYnTRW5ITVJ?
NCI-H1417MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MXrJR|UxRTN5MD6wOEBvVQ>?NUXpWJdiW0GQR1XS
DSH1MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NYDw[5JRUUN3ME2zO|IvPzJibl2=NF\r[ZpUSU6JRWK=
CAKI-1NGr2cpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NHrvOGVKSzVyPUO3OU41QCCwTR?=MXXTRW5ITVJ?
SIMAMV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MUTJR|UxRTN6MT64OkBvVQ>?MkLuV2FPT0WU
LS-1034MlrIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MkXsTWM2OD1|OESuOVEhdk1?NG\obpRUSU6JRWK=
K-562MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MlHWTWM2OD1|OEWuPEBvVQ>?Ml;GV2FPT0WU
LOXIMVIM2XpSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NFvKSYNKSzVyPUO4PU4yQSCwTR?=NGW3U2tUSU6JRWK=
MC116NVvIOpRXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M1zLU2lEPTB;M{mxMlQyKG6PNYnXUHgyW0GQR1XS
MPP-89NYPBNmtpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MoXDTWM2OD1|OUKuPVQhdk1?NXP2OmtGW0GQR1XS
SN12CM1jOO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MX;JR|UxRTN7ND64O{BvVQ>?MY\TRW5ITVJ?
BHT-101NILNWHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M1fQ[GlEPTB;M{m1MlkzKG6PNI\WRnNUSU6JRWK=
DMS-114MkG0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MUXJR|UxRTN7Nj6zNUBvVQ>?NVP1W41NW0GQR1XS
NCI-H1838NHy5WVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MUPJR|UxRTRyNT6wOUBvVQ>?NY\JOop3W0GQR1XS
HTM1ntVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MmO5TWM2OD12MEWuNVUhdk1?MVXTRW5ITVJ?
Caov-3MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NGjMVIJKSzVyPUSwOk4yQSCwTR?=NYDNT3F4W0GQR1XS
LB2518-MELMlrIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NELmSJZKSzVyPUSxN{4yKG6PMl2xV2FPT0WU
C3ANFXNcm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NHLWOXRKSzVyPUSxOU44QSCwTR?=MWDTRW5ITVJ?
NCI-H226M1m4SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MU\JR|UxRTRzNj62OEBvVQ>?M4LHVnNCVkeHUh?=
KMS-12-PENYq2do95T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M{nRU2lEPTB;NEG4MlA3KG6PNXPnTWlUW0GQR1XS
RERF-LC-MSMl\1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NH\tV|NKSzVyPUSyOU4xPSCwTR?=MmrvV2FPT0WU
OE33NE[3TJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MXvJR|UxRTR{Nj6wNkBvVQ>?NGLvcZhUSU6JRWK=
COLO-678NH7jN4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MofYTWM2OD12MkeuNVghdk1?MVrTRW5ITVJ?
NCI-H1963NH7NTYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NGrGSIhKSzVyPUSzNE4yOSCwTR?=NHnsTINUSU6JRWK=
LAMA-84NXfy[GpZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M2fkcGlEPTB;NEO3MlMhdk1?M1XmRnNCVkeHUh?=
NCI-H2171NGCxXlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NUWxTmNMUUN3ME20OFAvPjdibl2=MoTCV2FPT0WU
U-266NFXhXopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NWHXSW1oUUN3ME20OVEvPDlibl2=M{C3THNCVkeHUh?=
SNU-C2BM1Ht[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M372NGlEPTB;NE[wMlk4KG6PMVLTRW5ITVJ?
T47DNV[5VYY4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NUnNOpZ5UUN3ME20OlkvPjlibl2=MlPXV2FPT0WU
TE-6NH\pVIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NW\yOplUUUN3ME20OlkvQDFibl2=NIDvU5pUSU6JRWK=
OVCAR-3M1zoXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MUfJR|UxRTR5MD60NUBvVQ>?MULTRW5ITVJ?
C-4-IINGfHcVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NGPlNJRKSzVyPUS3Nk42PiCwTR?=Mm\LV2FPT0WU
EFM-19NWK4e|FtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=Mln3TWM2OD12N{iuNlchdk1?NX30Z3c5W0GQR1XS
NCI-N87Mm\YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MnjXTWM2OD12N{muPVIhdk1?MnX4V2FPT0WU
NCI-H187NVjY[2g6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M2rwV2lEPTB;NEmzMlIyKG6PM2rE[3NCVkeHUh?=
MDA-MB-157NYrieGc5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M331cGlEPTB;NEm5MlAyKG6PNYi3[|VZW0GQR1XS
OPM-2NWXKcWR5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M1LabGlEPTB;NUCxMlgyKG6PM1XMUXNCVkeHUh?=
COLO-320-HSRMVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M3jRNGlEPTB;NUGzMlE3KG6PNXv0VnVMW0GQR1XS
RMG-IM33XS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7M1PNN2lEPTB;NUGzMlk5KG6PM1XXSHNCVkeHUh?=
IST-SL1NIr5OZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MU\JR|UxRTVzNz60NkBvVQ>?MnXUV2FPT0WU
UACC-893NF\nUnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=Mk\rTWM2OD13MkGuOVEhdk1?M4KzUXNCVkeHUh?=
BeckerM2fDXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M1L3XWlEPTB;NUKxMlg{KG6PMVvTRW5ITVJ?
HPAF-IIMonFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NIe4NnVKSzVyPUWyO{4zPCCwTR?=MX3TRW5ITVJ?
HCC1954MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M2DqcmlEPTB;NUSwMlg{KG6PMV\TRW5ITVJ?
SNU-449MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M2\3OmlEPTB;NUS4MlAyKG6PNWToNXZTW0GQR1XS
NCI-H1563MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MVfJR|UxRTV3Nj60PUBvVQ>?NIHlcVRUSU6JRWK=
HDLM-2NHHrdGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NHHzbZBKSzVyPUW2PE42QSCwTR?=M4mzNXNCVkeHUh?=
NCI-H69MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MkPYTWM2OD13NkiuPEBvVQ>?M{jRSHNCVkeHUh?=
NCI-SNU-5MmDCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M3ezVGlEPTB;NUewMlE2KG6PM17DcHNCVkeHUh?=
NCI-H1792MmfVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NIDHUZVKSzVyPUW3Nk41OyCwTR?=NWP5dplwW0GQR1XS
NCI-H2141NVTqUoNuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NXvpNVNrUUN3ME21O|MvPjlibl2=MUDTRW5ITVJ?
KMOE-2MnKzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MU\JR|UxRTV5Nj6zNkBvVQ>?MkDKV2FPT0WU
NCI-H1155M13tbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M3\MZmlEPTB;NUe5Mlg4KG6PMUTTRW5ITVJ?
LK-2M{HZemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NXHZT4xbUUN3ME21PFEvODdibl2=MXnTRW5ITVJ?
HCC1187MlPTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MoXkTWM2OD13OUGuOFchdk1?NV6welRsW0GQR1XS
EGI-1NFvvcZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NV[1RVZjUUN3ME21PVgvOjdibl2=NUO1RmFOW0GQR1XS
NCI-H1623M{Phc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MXfJR|UxRTZyND62JI5OM4HRXHNCVkeHUh?=
MN-60NIHoboZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NYrQbIFtUUN3ME22NFUvOzdibl2=M1vYbHNCVkeHUh?=
JARNYWxNWRMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MULJR|UxRTZ{NT65OUBvVQ>?M4TzUXNCVkeHUh?=
HCC1419NX3kN2tWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NYPIO2VmUUN3ME22N|EvPzRibl2=MmDSV2FPT0WU
LU-165NE\ic|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M{TLXmlEPTB;NkO5MlQhdk1?MoXUV2FPT0WU
TYK-nuNVjPV|VXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NHvZN2NKSzVyPU[2Nk42PSCwTR?=M1zJWnNCVkeHUh?=
DG-75NUi4[lJIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MlztTWM2OD14NkWuPFMhdk1?NFrtZndUSU6JRWK=
PFSK-1NXPlW3VYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NUT0[ZFDUUN3ME22O|gvODhibl2=MofTV2FPT0WU
MKN7MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NV3JZWU4UUN3ME22PFkvQTVibl2=NFO3ZZdUSU6JRWK=
DMS-153MmHYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?Mn\FTWM2OD14OUiuNVUhdk1?NEKweHRUSU6JRWK=
HTC-C3NYHvTWVKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M2nFemlEPTB;N{CzMlk1KG6PNInHd2FUSU6JRWK=
GCIYMVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MXjJR|UxRTd{NT6xNkBvVQ>?MYPTRW5ITVJ?
NCI-H1092MnfpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NGWzNlVKSzVyPUezO{46PSCwTR?=M3TnNHNCVkeHUh?=
EB-3NHLoPHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M17YRmlEPTB;N{exMlAzKG6PNI\5PXNUSU6JRWK=
CAL-120NF7vZY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M2q0emlEPTB;N{e3MlUzKG6PNGPpeYpUSU6JRWK=
BT-474NVXtUnZ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=Mon1TWM2OD15N{iuPFEhdk1?MnrQV2FPT0WU
L-428MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MWnJR|UxRTd7MD65JI5OM2rlbXNCVkeHUh?=
Mo-TM3TBW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7Mnu1TWM2OD16MESuOlUhdk1?M2P5U3NCVkeHUh?=
CAL-72MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NIPEPW5KSzVyPUi0NE43PyCwTR?=M2jFSHNCVkeHUh?=
AsPC-1M3;FXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MWPJR|UxRTh3NT6yOkBvVQ>?M4\SUXNCVkeHUh?=
U-118-MGMkjwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MlO5TWM2OD16NU[uN|Qhdk1?NULCdWxWW0GQR1XS
GCTNYfUflJLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MUPJR|UxRTh4MT60PEBvVQ>?NYK1WWFEW0GQR1XS
EKVXMXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MWXJR|UxRTh5MT64O{BvVQ>?M4HhN3NCVkeHUh?=
NCI-H1755NGq0O|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NHm5fWRKSzVyPUi3N{42OiCwTR?=NYD5VFh[W0GQR1XS
Capan-2Ml75S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NXHtUIlqUUN3ME24PVgvOTFibl2=NHHQcJBUSU6JRWK=
NCI-H1793Ml7XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MoOxTWM2OD17MECuPFchdk1?NHXaenhUSU6JRWK=
PLC-PRF-5M{DlRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MVXJR|UxRTlyMT6zOUBvVQ>?MknCV2FPT0WU
M14Mof2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M3fEXmlEPTB;OUC1MlI4KG6PMlX2V2FPT0WU
SK-MEL-24MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?Mn6zTWM2OD17MUSuN|Uhdk1?MmTRV2FPT0WU
SK-MM-2NIHxN4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NYPvfmVYUUN3ME25OFIvOyCwTR?=MV7TRW5ITVJ?
PC-3MkLGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MVPJR|UxRTl3Nz6yNkBvVQ>?NVq4[phLW0GQR1XS
EW-24MmTBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NUHre4JTUUN3ME25O|AvPCCwTR?=MnS3V2FPT0WU
MDA-MB-175-VIINFTDWVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M1zEbWlEPTB;OUexMlU{KG6PNXzpWXVrW0GQR1XS
NCI-H1581NIfKSItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NGfDd3ZKSzVyPUm4NU4{OSCwTR?=NH3UbXBUSU6JRWK=
THP-1NW\3WYVsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NFHLbWFKSzVyPUm4PU41OiCwTR?=MlP0V2FPT0WU
NCI-H1993M2XhZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MV7JR|UxRTFwMECwO|Yh|ryPMX\TRW5ITVJ?
DOKNVvpUZJrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NXjCOYNjUUN3ME2xMlAyPzZ{IN88US=>MlPoV2FPT0WU
KINGS-1MlzzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MlHETWM2OD1zLkCxPUDPxE1?MnnpV2FPT0WU
YTNGHKdHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MX\JR|UxRTFwMES1Olgh|ryPMY\TRW5ITVJ?
TGBC1TKBMlzYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NXXqXJZTUUN3ME2xMlA3ODN4IN88US=>NV:1Z3NEW0GQR1XS
TCCSUPNGDWSZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MUTJR|UxRTFwMkOwPFMh|ryPMn7oV2FPT0WU
BENMVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MkPYTWM2OD1zLkKzO|QzKM7:TR?=M3zrTHNCVkeHUh?=
KARPAS-45NHz4bGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MlLXTWM2OD1zLkK2O|Y{KM7:TR?=M1v0XHNCVkeHUh?=
COLO-829Mn7ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NXfibYhWUUN3ME2xMlI4PDhizszNMVLTRW5ITVJ?
UACC-62NYn3O3B{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MnTGTWM2OD1zLkOyNVQ2KM7:TR?=MojZV2FPT0WU
NCI-H446NV7pS4x1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NY\0Zo5TUUN3ME2xMlM{PzdzIN88US=>NUjmZVVQW0GQR1XS
RO82-W-1MnjHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?Mk\kTWM2OD1zLkO0N|M4KM7:TR?=M4jjZnNCVkeHUh?=
NCI-H2452NX\kU3RWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NXPTOGxXUUN3ME2xMlM4OTJ7IN88US=>M2nmTHNCVkeHUh?=
RLMnrLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NGX1SIhKSzVyPUGuOFIxPjZizszNNIOyU45USU6JRWK=
NCI-H1522NIja[FVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NUXEfYM1UUN3ME2xMlQ{OTV7IN88US=>M2fPbnNCVkeHUh?=
TGWNV7MU3JJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NYPFOHZiUUN3ME2xMlQ2QTR{IN88US=>M1W2fnNCVkeHUh?=
HT55MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MUPJR|UxRTFwNEexOlgh|ryPNHPqNlZUSU6JRWK=
KARPAS-299M1TXOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MV\JR|UxRTFwNEe4OFEh|ryPNGfyTWxUSU6JRWK=
KY821MkXDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M2XZeGlEPTB;MT60PVQzQSEQvF2=MVLTRW5ITVJ?
MDA-MB-231Mk\mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NVzWWZI2UUN3ME2xMlU{ODV3IN88US=>NFPjbFdUSU6JRWK=
NCI-H82MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NUjoWXVoUUN3ME2xMlU4ODJ4IN88US=>NIjTc2dUSU6JRWK=
MDA-MB-134-VIMmLaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MkfrTWM2OD1zLk[xO|EyKM7:TR?=Mly5V2FPT0WU
PANC-08-13MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MYDJR|UxRTFwNkOwPFQh|ryPMoSyV2FPT0WU
D-542MGMnqyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NXiySphoUUN3ME2xMlY2OzB3IN88US=>NGfPZ3RUSU6JRWK=
LC-1FNX\hcJBKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NH3pUIJKSzVyPUGuOlYzODNizszNMlzRV2FPT0WU
KP-N-YNNGrtXlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=Mly5TWM2OD1zLk[2N|Q{KM7:TR?=NHT2OHlUSU6JRWK=
MFE-280M3X1W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NH\5S5FKSzVyPUGuOlY5OTJizszNM2Pub3NCVkeHUh?=
S-117NVzpOJdbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NGH2[IxKSzVyPUGuO|A2ODRizszNMlXtV2FPT0WU
NCI-H1573M1zydmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MYXJR|UxRTFwN{G3N|Mh|ryPMo\BV2FPT0WU
BT-20M3vRPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NHjqPWJKSzVyPUGuO|QxPjhizszNNFraU2hUSU6JRWK=
NCI-H28M4Xscmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NFT1SopKSzVyPUGuO|QxPzhizszNNVf0VHFZW0GQR1XS
CaR-1MnS2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NVO2eVE{UUN3ME2xMlc5OzJ2IN88US=>MlS3V2FPT0WU
LN-405M3;RZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M{f6XWlEPTB;MT64NFE1OyEQvF2=NGTtemhUSU6JRWK=
RT4MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NVrrbGllUUN3ME2xMlg1PDF5IN88US=>M1HEcHNCVkeHUh?=
NCI-H889MnvRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NX3ZNGM5UUN3ME2xMlk{QDh4IN88US=>MXPTRW5ITVJ?
SW1463MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MnrPTWM2OD1zLkm1O|AyKM7:TR?=M13qZ3NCVkeHUh?=
SCLC-21HM2WxPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MmLtTWM2OD1{LkCwOlI1KM7:TR?=M3vESHNCVkeHUh?=
CP66-MELNVTpcpptT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NH\rVGFKSzVyPUKuNFE4PjdizszNNYn0VZZqW0GQR1XS
Hs-578-TNIX1enJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M{jOO2lEPTB;Mj6wNVc5OiEQvF2=MV;TRW5ITVJ?
HCC70NIDteWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MlfZTWM2OD1{LkC1OFY{KM7:TR?=MmPkV2FPT0WU
SW1088NWTwPWUxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NGC5SmlKSzVyPUKuNFY6OzFizszNM1yzTXNCVkeHUh?=
NB6M3vhfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M3f3dWlEPTB;Mj6xPFUh|ryPM1zBeXNCVkeHUh?=
KU-19-19NWjiVmoxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NUWyUGhNUUN3ME2yMlI3QTF5IN88US=>M1vOW3NCVkeHUh?=
A704M1LpbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NWDmfWN1UUN3ME2yMlI6OTN3IN88US=>M1PCdXNCVkeHUh?=
EVSA-TMX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NV;TcG1yUUN3ME2yMlMxODh7IN88US=>M1\TfnNCVkeHUh?=
HCT-15M{[5c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NVq4fYI6UUN3ME2yMlM2PDZ4IN88US=>M1PMVHNCVkeHUh?=
HuO-3N1NV\PWW9vT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MWjJR|UxRTJwM{[1PFMh|ryPNHniR4RUSU6JRWK=
GMS-10NGfTWIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NEjYeIlKSzVyPUKuN|k4OzhizszNNV\3O3VsW0GQR1XS
TGBC24TKBNYTwNod5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MkTJTWM2OD1{LkSxOFI6KM7:TR?=MmnWV2FPT0WU
C2BBe1M3L2d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NUnQPYJ5UUN3ME2yMlUyOzJ6IN88US=>MWTTRW5ITVJ?
SK-N-DZNF3O[3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M{j2R2lEPTB;Mj61OlU6OiEQvF2=NUC1flM6W0GQR1XS
SK-N-ASNYThU2I2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NIP2fVBKSzVyPUKuO|MxOTVizszNMnfvV2FPT0WU
T98GM4fRXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MorITWM2OD1{LkiwOFAyKM7:TR?=NYLYVpc4W0GQR1XS
DMS-79MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M3X3Z2lEPTB;Mj65NFk5QCEQvF2=MWLTRW5ITVJ?
SNU-475MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MnW4TWM2OD1{LkmyOVczKM7:TR?=NHHXS4tUSU6JRWK=
COLO-792MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MnW4TWM2OD1|LkCyPFch|ryPNIDPcYZUSU6JRWK=
YAPCM4\x[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MoL4TWM2OD1|LkOyPFMzKM7:TR?=M1fMSXNCVkeHUh?=
UACC-812MlG1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NWH3VnRlUUN3ME2zMlM{PzN6IN88US=>MnrtV2FPT0WU
MewoMUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MWHJR|UxRTNwNE[wPFYh|ryPMV3TRW5ITVJ?
COLO-824MoDTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MYnJR|UxRTNwNUezO|gh|ryPNUPT[pN2W0GQR1XS
SCC-9Ml7pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NUnPO4Y2UUN3ME2zMlkyOzB7IN88US=>M1fybXNCVkeHUh?=
CP50-MEL-BMmCzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NHHq[4FKSzVyPUOuPVg4ODNizszNNWPTV|V2W0GQR1XS
NCI-H345MlTOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NV2xS3B4UUN3ME20MlAyOTd2IN88US=>NWP2e|M1W0GQR1XS
COR-L88NULseItlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MljSTWM2OD12LkO5OVgh|ryPMmriV2FPT0WU
RCM-1MmLBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?Mo\qTWM2OD12LkS5NlczKM7:TR?=MVHTRW5ITVJ?
JVM-3M1;aS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NGTnbGFKSzVyPUSuOlA3OThizszNMln6V2FPT0WU
ECC4MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MmrWTWM2OD12Lke2OVQyKM7:TR?=M1;HfXNCVkeHUh?=
MDA-MB-453NIna[2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NXOycZNwUUN3ME20Mlg2OTN2IN88US=>NF\kVHVUSU6JRWK=
SK-N-FIM2PZZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M3vvbWlEPTB;NT6yNlg4PyEQvF2=NY\L[YQ{W0GQR1XS
D-502MGMY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MmG1TWM2OD13LkK0NlYzKM7:TR?=NIrS[4dUSU6JRWK=
NCI-H2227NWnUTmJ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MlXJTWM2OD13LkO2NlMyKM7:TR?=NUXlXpc{W0GQR1XS
DMS-53NF\5epJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MYrJR|UxRTZwMUexNFYh|ryPNVjKeZdqW0GQR1XS
LB771-HNCNWDveGNvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NYHjVIUxUUN3ME22MlQ3QDB4IN88US=>M{D2XXNCVkeHUh?=
BB49-HNCMX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MV7JR|UxRTdwNEG3PVEh|ryPMlzyV2FPT0WU
MDA-MB-415NWfvfXN6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M4LPdWlEPTB;Nz61O|MxOyEQvF2=MnywV2FPT0WU
TALL-1M2Dqd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NVLrO3VDUUN3ME23Mlk3QDhizszNMmT0V2FPT0WU
HCC1395NHvUTXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NUDQbIRJUUN3ME24MlE2OTJ{IN88US=>MV;TRW5ITVJ?
EFE-184M{fCbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NFf2NpRKSzVyPUiuN|czOTZizszNNXi0N5hoW0GQR1XS
EC-GI-10MlewS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NWTMSow4UUN3ME24MlY5Pjh4IN88US=>M{DYOHNCVkeHUh?=
TTMn7CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MWfJR|UxRTlwME[5OlYh|ryPNGq0TlFUSU6JRWK=
U-2-OSMWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NGjWendKSzVyPUmuPFE{QTNizszNNXviR2lHW0GQR1XS
SHP-77MoTCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NVnsRWtXUUN3ME25MlkxOjlizszNMYjTRW5ITVJ?
HCC1143MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NHvtfINKSzVyPUGwMlQ4QTdizszNMYHTRW5ITVJ?
A498MmCzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MWTJR|UxRTF6LkK5O|Yh|ryPMYPTRW5ITVJ?
LS-513NYq4VYVkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M3W3[WlEPTB;MUiuOlA6OyEQvF2=NGjPdHBUSU6JRWK=
K052NFnFO3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MVXJR|UxRTJzLkS0NVgh|ryPNFnJRpFUSU6JRWK=
SiHaMYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M1fONWlEPTB;MkOuN|M4OSEQvF2=MnS2V2FPT0WU
RCC10RGBM3XtdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NYrINZAyUUN3ME2zNE4xPjFzIN88US=>MXHTRW5ITVJ?
NCI-SNU-16NUTpTHFoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NXzkb|Q1UUN3ME2zNU4yQDN4IN88US=>NIjCbplUSU6JRWK=
SNU-C1M1PQXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NXLEUHMxUUN3ME2zNk41OTd3IN88US=>NH7qdJVUSU6JRWK=
C32MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MkCyTWM2OD1|Mj64O|Ih|ryPMXTTRW5ITVJ?
SW684M3\hfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NIHvSHJKSzVyPUO0MlE2PjFizszNNVr3N5F[W0GQR1XS
SK-MEL-28NI\MOHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MomzTWM2OD1|NT61N|c4KM7:TR?=MYfTRW5ITVJ?
SK-MEL-1MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M1jPemlEPTB;M{[uO|U1PyEQvF2=NGK4d5pUSU6JRWK=
NCI-H720NXvrUGVTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MVTJR|UxRTRzLkm3NlYh|ryPM2K3VHNCVkeHUh?=
P31-FUJMlT5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M{XCUWlEPTB;NESuN|I5PCEQvF2=NEHYdGdUSU6JRWK=
NCI-H524MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M1mwR2lEPTB;NEiuPFI1QCEQvF2=M2DlR3NCVkeHUh?=

... Click to View More Cell Line Experimental Data

In vivo In vivo, Doxorubicin in combination with adenoviral MnSOD (AdMnSOD) plus 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) has the greatest effect in decreasing the volumes of MB231 tumors and prolonging survival of mice. [1] Although its use is limited by the chronic and acute toxic side effects it produces, Doxorubicin is essential in treating breast and oesophageal carcinomas, solid tumours in childhood, osteosarcomas, Kaposi's sarcoma, soft tissue sarcomas, and Hodgkin and non-Hodgkin lymphomas. [2]
Features

Protocol(Only for Reference)

Animal Study: [1]

Animal Models Female athymic nude mice injected s.c. with MB231 cells
Formulation Dissolved in DMSO, and diluted in saline
Dosages 3 mg/kg/day
Administration Delivered intratumorly

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDog
Weight (kg)0.020.151.80.40.0810
Body Surface Area (m2)0.0070.0250.150.050.020.5
Km factor36128520
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

References

[1] Sun W, et al. Cancer Res, 2009, 69(10), 4294-4300.

[2] Granados-Principal S, et al. Food Chem Toxicol, 2010, 48(6), 1425-1438.

view more

Clinical Trial Information( data from http://clinicaltrials.gov, updated on 2016-07-30)

NCT Number Recruitment Conditions Sponsor
/Collaborators
Start Date Phases
NCT02839707 Not yet recruiting Fallopian Tube Clear Cell Adenocarcinoma|Fallopian Tube Endometrioid Adenocarcinoma|High Grade Fallopian Tube Serous Adenocarcinoma|High Grade Ovar  ...more Fallopian Tube Clear Cell Adenocarcinoma|Fallopian Tube Endometrioid Adenocarcinoma|High Grade Fallopian Tube Serous Adenocarcinoma|High Grade Ovarian Serous Adenocarcinoma|Ovarian Clear Cell Adenocarcinoma|Ovarian Endometrioid Adenocarcinoma|Ovarian Seromucinous Carcinoma|Primary Peritoneal High Grade Serous Adenocarcinoma|Recurrent Fallopian Tube Carcinoma|Recurrent Ovarian Carcinoma|Recurrent Primary Peritoneal Carcinoma|Undifferentiated Fallopian Tube Carcinoma|Undifferentiated Ovarian Carcinoma National Cancer Institute (NCI) May 2017 Phase 2|Phase 3
NCT02743065 Not yet recruiting Hepatocellular Carcinoma Fifth Affiliated Hospital, Sun Yat-Sen University|Third A  ...more Fifth Affiliated Hospital, Sun Yat-Sen University|Third Affiliated Hospital, Sun Yat-Sen University September 2016 --
NCT01775475 Not yet recruiting AIDS-related Diffuse Large Cell Lymphoma|AIDS-related Diffuse Mixed Cell Lymphoma|AIDS-related Diffuse Small Cleaved Cell Lymphoma|AIDS-related Imm  ...more AIDS-related Diffuse Large Cell Lymphoma|AIDS-related Diffuse Mixed Cell Lymphoma|AIDS-related Diffuse Small Cleaved Cell Lymphoma|AIDS-related Immunoblastic Large Cell Lymphoma|AIDS-related Lymphoblastic Lymphoma|AIDS-related Peripheral/Systemic Lymphoma|AIDS-related Small Noncleaved Cell Lymphoma|Stage III AIDS-related Lymphoma|Stage IV AIDS-related Lymphoma AIDS Malignancy Consortium|National Cancer Institute (NCI  ...more AIDS Malignancy Consortium|National Cancer Institute (NCI)|The EMMES Corporation September 2016 Phase 2
NCT02783599 Not yet recruiting Soft Tissue Sarcoma Eli Lilly and Company September 2016 Phase 1
NCT02685657 Not yet recruiting Triple Negative Breast Cancer Russian Academy of Medical Sciences|Russian Society of Cl  ...more Russian Academy of Medical Sciences|Russian Society of Clinical Oncology September 2016 Phase 2

view more

Chemical Information

Download Doxorubicin (Adriamycin) SDF
Molecular Weight (MW) 579.98
Formula

C27H29NO11.HCl

CAS No. 25316-40-9
Storage 3 years -20℃powder
6 months-80℃in solvent
Synonyms NSC 123127
Solubility (25°C) * In vitro DMSO 100 mg/mL warming (172.41 mM)
Water 20 mg/mL (34.48 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Name (8S,10S)-10-((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyl-tetrahydro-2H-pyran-2-yloxy)-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione hydrochloride

Frequently Asked Questions

  • Question 1
    Why the IC50 of the compound varied over time in our measurement?

    Answer: Sometimes the IC50 value might vary between different batch of compounds due to the slight differences in purity. If different IC50 was seen in the same batch of compound, the problem may lies in the process of dissolvement. Make sure that you see no particles and the solution is clear with your stock solution.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

* Indicates a Required Field

Related Topoisomerase Products

  • SCR7

    SCR7 is a specific DNA Ligase IV inhibitor, which blocks nonhomologous end-joining (NHEJ).

  • Blasticidin S HCl

    Blasticidin S HCl is a nucleoside antibiotic isolated from Stretomyces girseochromogenes, and acts as a DNA and protein synthesis inhibitor, used to select transfected cells carrying bsr or BSD resistance genes.

  • LMK-235

    LMK-235 is a selective inhibitor of HDAC4 and HDAC5 with IC50 of 11.9 nM and 4.2 nM, respectively.

  • Etoposide

    Etoposide is a semisynthetic derivative of podophyllotoxin, which inhibits DNA synthesis via topoisomerase II inhibition activity.

  • Irinotecan

    Irinotecan is a topoisomerase I inhibitor for LoVo cells and HT-29 cells with IC50 of 15.8 μM and 5.17 μM, respectively.

    Features:Irinotecan is a prodrug that is used to treat metastatic colorectal cancer.

  • Camptothecin

    Camptothecin is a specific inhibitor of DNA topoisomerase I (Topo I) with IC50 of 0.68 μM in a cell-free assay. Phase 2.

  • Daunorubicin HCl

    Daunorubicin HCl inhibits both DNA and RNA synthesis and inhibits DNA synthesis with Ki of 0.02 μM in a cell-free assay.

  • SN-38

    SN-38 is an active metabolite of CPT-11, inhibits DNA topoisomerase I, DNA synthesis and causes frequent DNA single-strand breaks.

  • Topotecan HCl

    Topotecan HCl is a topoisomerase I inhibitor for MCF-7 Luc cells and DU-145 Luc cells with IC50 of 13 nM and 2 nM in cell-free assays, respectively.

    Features:Topotecan is a water-soluble derivative of camptothecin.

  • Idarubicin HCl

    Idarubicin HCl is a hydrochloride salt form of Idarubicin which is an anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells with IC50 of 3.3 ng/mL in a cell-free assay.

    Features:Idarubicin is a substrate for CYP450 2D6 and 2C9.

Recently Viewed Items

Tags: buy Doxorubicin (Adriamycin) | Doxorubicin (Adriamycin) ic50 | Doxorubicin (Adriamycin) price | Doxorubicin (Adriamycin) cost | Doxorubicin (Adriamycin) solubility dmso | Doxorubicin (Adriamycin) purchase | Doxorubicin (Adriamycin) manufacturer | Doxorubicin (Adriamycin) research buy | Doxorubicin (Adriamycin) order | Doxorubicin (Adriamycin) mouse | Doxorubicin (Adriamycin) chemical structure | Doxorubicin (Adriamycin) mw | Doxorubicin (Adriamycin) molecular weight | Doxorubicin (Adriamycin) datasheet | Doxorubicin (Adriamycin) supplier | Doxorubicin (Adriamycin) in vitro | Doxorubicin (Adriamycin) cell line | Doxorubicin (Adriamycin) concentration | Doxorubicin (Adriamycin) nmr
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Contact Us