Doxorubicin (Adriamycin) Licensed by Pfizer

Catalog No.S1208

Doxorubicin (Adriamycin) is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis in tumor cells.

Price Stock Quantity  
USD 117 In stock
USD 90 In stock
USD 210 In stock
USD 670 In stock
Bulk Inquiry

Massive Discount Available

Free Overnight Delivery on all orders over $ 500.

Doxorubicin (Adriamycin) Chemical Structure

Doxorubicin (Adriamycin) Chemical Structure
Molecular Weight: 579.98

Validation & Quality Control

Customer Product Validation(6)

Quality Control & MSDS

Related Compound Libraries

Product Information

  • Compare Topoisomerase Inhibitors
    Compare Topoisomerase Products
  • Research Area
  • Combination Therapy
    Combination Therapy

Product Description

Biological Activity

Description Doxorubicin (Adriamycin) is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis in tumor cells.
Targets Topo II [1]
(Tumor cells)
In vitro Doxorubicin, an antibiotic anthracycline, is commonly considered to exert its anti-tumor activity at two fundamental levels, altering DNA and producing free radicals to trigger apoptosis of cancer cells through DNA damage. Doxorubicin can block the synthesis of DNA by intercalating into the DNA strand, and inhibits DNA topoisomerase II (TOP2). Doxorubicin is most effective when cells are rapidly proliferating and expressing high levels of TOP2. Additionally, Doxorubicin can trigger apoptosis by producing ceramide (which prompts apoptosis by activating p53 or other downstream pathways such as JNK), the degradation of Akt by serine threonine proteases, the mitochondrial release of cytochrome c, increased FasL (death receptor Fas/CD95 ligand) mRNA production, and a greater production of free radicals. [2] Pre-treatment with GSNO (nitrosoglutathione) suppresses the resistance in the doxorubicin-resistant breast cancer cell line MCF7/Dx, accompanied by enhanced protein glutathionylation and accumulation of doxorubicin in the nucleus. [3] Doxorubicin induced G2/M checkpoint arrest are attributed to elevated cyclin G2 (CycG2) expression and phospho-modification of proteins in the ataxia telangiectasia mutated (ATM) and ATM and Rad3-related (ATR) signaling pathways. [5] Doxorubicin inhibits AMP-activated protein kinase (AMPK), resulting in SIRT1 dysfunction, p53 accumulation, and increased cell death in mouse embryonic fibroblasts (MEFs) and cardiomyocytes, which can be further sensitized by pre-inhibition of AMPK. [6] Doxorubicin elicits a marked heat shock response, and that either inhibition or silencing of heat shock proteins enhance the Doxorubicin apoptotic effect in neuroblastoma cells. Nanomolar Doxorubicin treatment of neuroblastoma cells causes dose-dependent over-ubiquitination of a specific set of proteins in the absence of measurable inhibition of proteasome, and loss of activity of ubiquitinated enzymes such as lactate dehydrogenase and α-enolase, the protein ubiquination patterns of which is similar to those with proteasome inhibitor Bortezomib, indicating that Doxorubicin may also exert its effect by damaging proteins. [8]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
L1210MWfGeY5kfGmxbjDBd5NigQ>?NFvy[2lKdmirYnn0bY9vKG:oIGLORUB{gW62aHXzbZMhf2m2aDDFSFUxKG:oIECuOVgh|ryPNUX2PW02PDlyNUO2
Yoshida sarcomaM{\hPWZ2dmO2aX;uJGF{e2G7MlLkTY5pcWKrdHnvckBw\iCdM1jdWIRTKGmwY3;ydI9z[XSrb36ge4l1cCCLQ{WwJI9nKDBwMEKg{txONGrTeZYyOzJ{OUi2
CHOMXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NFfZVGNKSzVyPUCuNFYh|ryPNXKwb5VvOTN3NEe1NC=>
8226M4eyRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NEPnfmZKSzVyPUCuNFM{KM7:TR?=M3XaNlE1PDd5M{C=
8226/ADRMmTiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?Ml;CTWM2OD1yLkW2JO69VQ>?NGjmOVcyPDR5N{Ow
MCF7/ADRMWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NUPuZnB2UUN3ME2zMlEh|ryPMkPSNVQ1Pzd|MB?=
H69NX3uR3M1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NYX5OWVkUUN3ME2wMlg4KM7:TR?=MkX5NVQ4QTV6NR?=
N417MmnDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NFHa[WlKSzVyPUCuNlMh|ryPM{PQRVE1Pzl3OEW=
H9M2nDS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MWfJcohq[mm2aX;uJI9nKEh7IHPlcIx{KGOqcn;ubYNidGy7IHnu[oVkfGWmIIfpeIghfGinIFjJWk0yKCiKOT;JTWlDMSC5aYToJGlFPTBib3[gNE4xOSEQvF2=MnW0NVU1QDZ6MR?=
T-C8166NFLjS3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NYXrUGU6UUR3ME2wMlAyKM7:TR?=NIP0SZYyPTR6Nkix
T-H9MmrQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M4nhUmlFPTB;MD6wNUDPxE1?MoC5NVU1QDZ6MR?=
T-MT4MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MYfJSFUxRTBwMEGg{txOMWCxOVQ5Pjhz
SKMEL-5MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MXjFSFUxRTNwMjFOwG0>MonVNVYyOzd3Mx?=
MLMMnXmR5l1d3SxeHnjJGF{e2G7NVHYOmluTUR3ME2wMlE{KM7:TR?=NHPjcHIyQDd3M{Ww
KBM-3M1PKUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MXzJR|UxRTBwMEK2JO69VQ>?MX:xPVk2QDd5
HT-29NF\iU5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MYmwMlAyKM7:Zx?=MnXjOFghcA>?M1HqWWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5NWjTN3U{Ojd5OES0PS=>
EMT6MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NHvkWHkxNjVizszNMXKxJIg>MU\Jcohq[mm2aX;uJI9nKHC{b3zp[oVz[XSrb36gZpkhdWWjc4XybY5oKG[xcjDzeZJ3cX[rbneg[pJi[3Srb37zJJdqfGhiRVS1NEBw\iByLkCwNFEh|ryPNWDRPJBiPzR3Mk[3OC=>
H2981MULDfZRwfG:6aXOgRZN{[Xl?NGCwZYpKSzVyPUCuOUDPxE1?MnLMO|c{OTB{Mx?=
LOXMknmR5l1d3SxeHnjJGF{e2G7NFTvclhKSzVyPUCuNFQzKM7:TR?=MmnyO|g2OzN|MR?=
C38MlPhR5l1d3SxeHnjJGF{e2G7MX\JR|UxRTBwMEGg{txOM134R|gxPTd{OUG=
EACMmHER5l1d3SxeHnjJGF{e2G7M1r3OFczKGh?NVTrRWo1UUN3ME2wMlM2KM7:TR?=NIDEXmc5OzVyMEi3
SKVLBMXvDfZRwfG:6aXOgRZN{[Xl?NYnEU5JGUUN3ME21MlYh|ryPNF7hR2M5PTd4OUG0
AUC375M3znZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NV7UfFRWUUN3ME2wMlEyOiEQvF2=NVX2UIpSQDZ2OE[wNC=>
A2780-C25NXrKWGw4S3m2b4TvfIlkKEG|c3H5Mn7nR5l1d3SxeHnjbZR6KGGpYXnud5Qhd3ijbHnwcIF1cW5vcnXzbZN1[W62IFGyO|gxNUN{NTD3bZRpKEmFNUCgc4YhOC5yNkOg{txONVy5O3k4QDh|MUe1OS=>
A2780-CP3NXPlV2toS3m2b4TvfIlkKEG|c3H5MljzR5l1d3SxeHnjbZR6KGGpYXnud5Qh[2m|cHzheIlvNXKnc3nzeIFvfCCDMke4NE1EWDNid3n0bEBKSzVyIH;mJFAvODV4IN88US=>NEjy[Fg5QDNzN{W1
A2780-DX5M4\pfWN6fG:2b4jpZ{BCe3OjeR?=MoDyR5l1d3SxeHnjbZR6KGGpYXnud5Qh\G:6b4L1ZolkcW5vcnXzbZN1[W62IFGyO|gxNUS[NTD3bZRpKEmFNUCgc4YhOC5|NUeg{txONWjYNYdqQDh|MUe1OS=>
MXF7M{XDfWN6fG:2b4jpZ{BCe3OjeR?=MVLBcpRqfHWvb4KgZYN1cX[rdImgZYdicW6|dDDz[Y5{cXSrdnWgUXhHPyC5aYToJGlEPTBib3[gNE4xOjhizszNMoniPFk3ODV3OB?=
MXF7MkKyR5l1d3SxeHnjJGF{e2G7NW\EXIJKSW62aYT1cY9zKGGldHn2bZR6KGGpYXnud5QhdWm2b4jhcpRzd26nLYLld4l{fGGwdDDNXGY4KHerdHigTWM2OCCxZjCwMlAzQCEQvF2=MV[4PVYxPTV6
MXF7MmHIR5l1d3SxeHnjJGF{e2G7MVLBcpRqfHWvb4KgZYN1cX[rdImgZYdicW6|dDDkc5hwenWkaXPpck1z\XOrc4ThcpQhVViINzD3bZRpKEmFNUCgc4YhOS5zN{Kg{txOM4T3Rlg6PjB3NUi=
WiDrNFnid4pEgXSxdH;4bYMhSXO|YYm=MXLBZ5Rqfmm2eTDh[4FqdnO2IIPlcpNqfGm4ZTDXbWRzKGOnbHyge4l1cCCLQ{WwJI9nKDBwMEWzJO69VQ>?NHzZSmo5QTZyNUW4
MCFM2HROGZ2dmO2aX;uJGF{e2G7M4XjfnJmfmW{c3HsJI9nKFBvZ4CtcYVlcWG2ZXSgcZVtfGmmcoXnJJJme2m|dHHuZ4Uh[XO|ZYPz[YQh[XNiZX7oZY5k\W2nboSgbY4h[3m2b4TvfIlkcXS7IH;mJIFlemmjbYnjbY4>MYi4PVg1OTVz
C6Mk\rR5l1d3SxeHnjJGF{e2G7M135XlIvPSCvZz;tUC=>M3X1fFczKGh?MVPEUXNQMorQR5l1d3SxeHnjbZR6KGGpYXnud5QhemG2IFO2JINmdGy|IHH0JFUxKHWpL33MJJRwKDJwNTDt[{9uVA>?MYe4PVg5PjB2
C6MkjYSpVv[3Srb36gRZN{[Xl?M{njeVIvPSCvZz;tUC=>MVG0JIg>Ml3aSG1UVw>?MXzJcohq[mm2aX;uJI9nKHS3YoXsbY4heG:ueX3ldol7[XSrb36=M{jqfVg6QDh4MES=
C6MWDDfZRwfG:6aXOgRZN{[Xl?MlnENk42KG2pL33MM2fCclUhcA>?NEK0TmlFVVORNHTtdFFEgXSxdH;4bYNqfHliYYPz[ZN{\WRiYYOgZ4VtdCC{ZXzlZZNmNY[0e4ZnQDl6OE[wOC=>
SKVLBNH2xVpBEgXSxdH;4bYMhSXO|YYm=M4rZV|czKGh?MW\JR|UxRTZwNUSg{txOMVe5NFA{PTJy
MCF7/VP16NUfXfIJpS3m2b4TvfIlkKEG|c3H5NVn1T5Z3PTBizsznM41NNFm2eJY4OiCqMY\JR|UxRTF2LkKg{txOM1zx[|kxOjJ5OUK=
CA755NEi0cndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MlnhNVAh|ryPNFrxOJI3KGR?NHzvSGRKSzVyPUCuNFE1KM7:TR?=MWO5OVI3PTdy
CHONFvySGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NY\YV5dnOTBizszNMni0OkBlMYfJR|UxRTBwME[g{txONGXHblM6PTJ4NUew
Panc02MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NY\3NZVzOTBizszNMYe2JIQ>NV:5S|lqUUN3ME2wMlA3PSEQvF2=NFfSXGk6PTJ4NUew
PC14NHmyN4VEgXSxdH;4bYMhSXO|YYm=MYq0JIQ>M{Tle2ROW09?M{CzfmlEPTB;MD6yPUDPxE1?NITZZXA6QDJ{NUSy
HOP62NVXve29oS3m2b4TvfIlkKEG|c3H5MXS3NkBpM2jacGlEPTB;MD6wNFQh|ryPNEWwbII6QDd|Nk[x
SF-295NYPjSFRTS3m2b4TvfIlkKEG|c3H5MYm3NkBpNETkVnZKSzVyPUCuNFM2KM7:TR?=MmPDPVg4OzZ4MR?=
MDA-MB-361M3Lme2N6fG:2b4jpZ{BCe3OjeR?=MlLaNUBpNGHZXGpFVVORMU\DfZRwfG:6aXPpeJkh[WejaX7zeEBOTEFvTVKtN|YyKGW6cILld5NqdmdiTHHjXkB4cXSqIFnDOVAhd2ZiMD6wNVIh|ryPNED5OGMyODN7NUS5NC=>
MDA-MB-361M{SyZWN6fG:2b4jpZ{BCe3OjeR?=NY\SfFlnOSCqMnrlSG1UVw>?NWDJZlBiS3m2b4TvfIlkcXS7IHHnZYlve3RiTVTBJG1DKDN4MTDlfJBz\XO|aX7nJINiemKxeInw[ZB1cWSjc3Wgd5REWEd{IIfpeIghUUN3MDDv[kAxNjBzODFOwG0>MlTYNVA{QTV2OUC=
CCRF-SBNEfq[|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M3nqVlQh\A>?M4T4cmROW09?M4jNdWlEPTB;MD6wNUDPxE1?M1rFcVExPDFzNEe2
CHO-K1NXfnW4o{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=Mn\COEBlNXXDe2VtTE2VTx?=M3XXbGlEPTB;MD60JO69VQ>?M1zuOlExPDFzNEe2
KBMUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NV3BZ3M3PCCmNGjGfZdFVVORNH\2RWlCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIRzfWdvcnXzbZN1[W62IFvCO2Qhf2m2aDDJR|UxKG:oIECuOlUh|ryPNXmwS|dkOTB2MUG0O|Y>
KBM{jnemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M4HPNVQh\A>?MWXEUXNQM4PqZ2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4Sg[JJ2\y2{ZYPpd5RidnRiS1LDZY1xf2m2aDDJR|UxKG:oIECuNFYh|ryPMVGxNFQyOTR5Nh?=
KBNHHEVpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NG\mOlE1KGR?MoS0SG1UVw>?MoTJRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDkdpVoNXKnc3nzeIFvfCCNQl3EVkB4cXSqIFnDOVAhd2ZiMD61JO69VQ>?M2TnRVExPDFzNEe2
KBNVX6[lVpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NU\1c|Z4PCCmNEHX[JlFVVORNVHKNXBTSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBlenWpLYLld4l{fGGwdDDLRnYzOENid3n0bEBKSzVyIH;mJFAvPCEQvF2=NHTyNXcyODRzMUS3Oi=>
HTB-54NVzkWG1xS3m2b4TvfIlkKEG|c3H5NYfMbIR2OTByIN88US=>MY\JR|UxRTFwMTFOwG0>M2TQT|ExPDd4OE[x
MEL-ACM1vy[GN6fG:2b4jpZ{BCe3OjeR?=NF;PRYwyODBizszNMULJR|UxRTFwMjFOwG0>MlX3NVA1PzZ6NkG=
DU145MVvDfZRwfG:6aXOgRZN{[Xl?MV[3NkBpM1\mU2lEPTB;MD6wOVI5KM7:TR?=MoXmNVA1Pzl{OEK=
K562RMmjGR5l1d3SxeHnjJGF{e2G7NXWwboFmPzJiaB?=NF25do5KSzVyPUCuNFE2PiEQvF2=NHy0SpoyODR5OUK4Ni=>
PACA-2Mn7UR5l1d3SxeHnjJGF{e2G7NETU[nE3KGR?NIXTUlZGTDVyPUCuNFA3OyEQvF2=NIXIUIYyODR7OEKxOC=>
3Y1NWfPbGdWS3m2b4TvfIlkKEG|c3H5MkXXO|IhcA>?NIDrRlBIUTVyPUCuNFA{QCEQvF2=MlmyNVA3QTF5MUC=
P388MWHDfZRwfG:6aXOgRZN{[Xl?NFLZPHk4OiCqNYnrXFZxT0l3ME2wMlAyOiEQvF2=MWCxNFY6OTdzMB?=
HMV-1MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NGXqeHhKSzVyPUCuNlgh|ryPNV:5colCOTB4OUi0N|Y>
MKN-1NVj5TWJoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M1XQb2lEPTB;MD62OEDPxE1?NULpbodXOTB4OUi0N|Y>
PC14MkjuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M3e0V2lEPTB;MT65JO69VQ>?NIjIZXQyODZ7OESzOi=>
T24NIDrcYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NU\yRVhXUUN3ME2wMlY1KM7:TR?=MkntNVA3QTh2M{[=
U937MXTGeY5kfGmxbjDBd5NigQ>?M2\WTVI1KGh?MWnEUXNQNHTVbmtKdmirYnn0d{BqdmOxcoDvdoF1cW:wIH;mJHs{UF22aIntbYRqdmVid3n0bEBKSzVyIH;mJFAvOSEQvF2=NYfYbYlmOTB5OEC5NVE>
H460pv8/etoMVTDfZRwfG:6aXOgRZN{[Xl?MU[xNFAh|ryPMkflOFghcA>?MVLTZYxqdmV?MlH1TWM2OD1yLkCyJO69VQ>?NFvQXpEyODd6MEmxNy=>
H460pv8NWfyU45RS3m2b4TvfIlkKEG|c3H5M2e2elExOCEQvF2=NGrvO4Y1QCCqNXL5fVliW2GuaX7lMoPoTWM2OD1yLkCwOEDPxE1?M1rabFExPzhyOUGz
MDA-231M1vXNmN6fG:2b4jpZ{BCe3OjeR?=M3[zUVExOCEQvF2=NIq3VXA1QCCqNVLmSWt5W2GuaX7lM1W0VWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KE2GQT2yN|Eh[2WubDCoSXIuNEWJRmKrMI12fGGwdDDwOVMqKHerdHigTWM2OCCxZjCwMlAxPiEQvF2=MYexNFc5ODlzMx?=
MDA-468NXGzfHNOS3m2b4TvfIlkKEG|c3H5Mm\XNVAxKM7:TR?=NV\NfGhHPDhiaB?=NFrpO4xU[WyrbnW=NF\CUZdEgXSxdH;4bYNqfHliYXfhbY5{fCCPRFGtOFY5KGOnbHygLGVTNSxiYX3wcIlncWWmIFXHSnItKG23dHHueEBxPTNrIIfpeIghUUN3MDDv[kAxNjByNTFOwG0>NFrvS|cyODd6MEmxNy=>
NCI-H226NGC2XmVEgXSxdH;4bYMhSXO|YYm=NXLFepdlOTByIN88US=>NVXiW4V[PDhiaB?=MVLTZYxqdmV?MUDDfZRwfG:6aXPpeJkh[WejaX7zeEBPS0lvSEKyOkBk\WyuIDjteZRidnRicEWzLUB4cXSqIFnDOVAhd2ZiMD6wNFgh|ryPMlHQNVA4QDB7MUO=
NCI-H322NWTZR5hsS3m2b4TvfIlkKEG|c3H5MYixNFAh|ryPMXW0PEBpM{D0SnNidGmwZR?=Mnf2R5l1d3SxeHnjbZR6KGGpYXnud5QhVkOLLVizNlIh[2WubDCocZV1[W62IIC1N{khf2m2aDDJR|UxKG:oIECuNFMh|ryPNILSVGEyODd6MEmxNy=>
NCI-H358MUTDfZRwfG:6aXOgRZN{[Xl?NHix[4IyODBizszNNGHpWog1QCCqMoHvV4FtcW6nMlm2R5l1d3SxeHnjbZR6KGGpYXnud5QhVkOLLVizOVgh[2WubDCocZV1[W62IIC1N{khf2m2aDDJR|UxKG:oIECuNVMh|ryPNIi1WHQyODd6MEmxNy=>
NCI-H647NIrZWWREgXSxdH;4bYMhSXO|YYm=MWWxNFAh|ryPMWq0PEBpNHHpfGFU[WyrbnW=NUCxPHMyS3m2b4TvfIlkcXS7IHHnZYlve3RiTlPJMWg3PDdiY3XscEApdXW2YX70JJA2Oylid3n0bEBKSzVyIH;mJFAvODBzIN88US=>NFTUZ3YyODd6MEmxNy=>
SKBR-3NWrtUolnS3m2b4TvfIlkKEG|c3H5NV6yOVN2OTByIN88US=>M2rsbFQ5KGh?MXPTZYxqdmV?MofFR5l1d3SxeHnjbZR6KGGpYXnud5QhW0uEUj2zJINmdGxiKFXSMYFueGyrZnnl[EBmekJ{LH31eIFvfCCyNUOpJJdqfGhiSVO1NEBw\iByLkCyJO69VQ>?NYLpdodtOTB5OEC5NVM>
T47DM1LvcWN6fG:2b4jpZ{BCe3OjeR?=NGL2Z3IyODBizszNNVP1dFhSPDhiaB?=M2TRdXNidGmwZR?=NITE[5NEgXSxdH;4bYNqfHliYXfhbY5{fCCWNEfEJINmdGxiKFXSL{xufXSjboSgdFU{MSC5aYToJGlEPTBib3[gNE4xODdizszNMmewNVA4QDB7MUO=
ZR-75-1NV3IeFdzS3m2b4TvfIlkKEG|c3H5M1L3VVExOCEQvF2=NUfhUpNMPDhiaB?=MlLBV4FtcW6nM1HFdGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KFqULUe1MVEh[2WubDCoSXIsNHCpcjuscZV1[W62IIC1N{khf2m2aDDJR|UxKG:oIECuNFA6KM7:TR?=NUDoN5VSOTB5OEC5NVM>
L1210MlS2R5l1d3SxeHnjJGF{e2G7M{PFUGlEPTB;MD6wNlUh|ryPNGn1cngyODh7MEG2Oy=>
D40MVPDfZRwfG:6aXOgRZN{[Xl?MVeyOEBpMYDEUXNQMXfJR|UxRTFwMUeyJO69VQ>?NVLXRmZQOTB7NU[yNVQ>
OVCAR-3M1LhSmN6fG:2b4jpZ{BCe3OjeR?=MVeyOEBpM4C0bmROW09?M2PVc2lEPTB;MD6wN|Uh|ryPMmjINVA6PTZ{MUS=
UA375NXzEcG4{S3m2b4TvfIlkKEG|c3H5NXPuenpVOjRiaB?=NFH1ZnJFVVORMonKTWM2OD1yLkGxNkDPxE1?M1fhd|ExQTV4MkG0
CH1MWjDfZRwfG:6aXOgRZN{[Xl?NGLVc5o6PiCqNGrOR5BFVVORMnvGTWM2OD1yLkCwOlMh|ryPMUSxNVEzOzl6OR?=
RENCAMUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M4rnSFQ5KGh?MnrDTWM2ODxyLkCxJO69VQ>?Mk\lNVE1PTR2Nke=
CNSNInieGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NVHvS2tmPDhiaB?=M4rNXWdKPTB;MD6wOlQh|ryPM3jrdlEyPDd|NEG4
J82Mk\XR5l1d3SxeHnjJGF{e2G7NHfIPYoyOCEQvF2=MnrDSG1UVw>?MkHWR5l1d3SxeHnjbZR6KGGpYXnud5QhUjh{IIPlcpNqfGm4ZTDj[YxtKHerdHigTWM2OCCxZjCwMlA{KM7:TR?=M{[2c|EyPjB4MUSx
LoVoMVrDfZRwfG:6aXOgRZN{[Xl?M1fMNVExKM7:TR?=MUXEUXNQNFTBW2tEgXSxdH;4bYNqfHliYXfhbY5{fCCOb2\vJJNmdnOrdHn2[UBk\WyuIIfpeIghUUN3MDDv[kAxNjByODFOwG0>NWiyfWFQOTF4ME[xOFE>
T24M3\ZUWN6fG:2b4jpZ{BCe3OjeR?=NF71RnUyOCEQvF2=M4LJNGROW09?NWn5NIoyS3m2b4TvfIlkcXS7IHHnZYlve3RiVEK0JJNmdnOrdHn2[UBk\WyuIIfpeIghUUN3MDDv[kAxNjB{IN88US=>MWmxNVYxPjF2MR?=
U373NWnEdGo6S3m2b4TvfIlkKEG|c3H5NWftR5lDOTBizszNMVjEUXNQMYjDfZRwfG:6aXPpeJkh[WejaX7zeEBWOzd|IIPlcpNqfGm4ZTDj[YxtKHerdHigTWM2OCCxZjCwMlAyKM7:TR?=MXexNVYxPjF2MR?=
U87NXW3e4lXS3m2b4TvfIlkKEG|c3H5MYGxNEDPxE1?NGns[IpFVVORMkO3R5l1d3SxeHnjbZR6KGGpYXnud5QhXTh5IIPlcpNqfGm4ZTDj[YxtKHerdHigTWM2OCCxZjCwMlA3KM7:TR?=MV6xNVYxPjF2MR?=
U87MVnDfZRwfG:6aXOgRZN{[Xl?MVSxNEDPxE1?MoPUSG1UVw>?M2X3cmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KFV6NzDy[ZNqe3SjboSgZ4VtdCC5aYToJGlEPTBib3[gNE4yPCEQvF2=MX2xNVYxPjF2MR?=
UACC62MnjtR5l1d3SxeHnjJGF{e2G7NI\6fJg{NTVibR?=MXHEUXNQM3vTVmdKPTB;MD6wPVQh|ryPNUjUbY4zOTF4N{i2OFk>
SKVLB1NYD6VIN7S3m2b4TvfIlkKEG|c3H5M13HVFczKGh?M2LRSmROW09?MkDRR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gcZVtfGmmcoXnMZJme2m|dHHueEBUU1[OQkGgZ4VtdCC5aYToJGlEPTBib3[gNk4zKM7:TR?=M4fHNFEyPzV2NkCy
HCT116NULsdpJIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NInN[GVIUTVyPUCuNFI{KM7:TR?=NIK2R3gyOTd3NUO2Ny=>
COR-L23MkexR5l1d3SxeHnjJGF{e2G7NIH1dHQ2NTZiZB?=MVLJR|UxRTBwMEKwNUDPxE1?NHfUTGMyOThyNkeyOC=>
H69PM1\3PWN6fG:2b4jpZ{BCe3OjeR?=MYK1MVYh\A>?NW\YdGU3UUN3ME2wMlAzPzNizszNNFfBU2syOThyNkeyOC=>
H69/LX4MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M3mwe|Qh\A>?MWDJcohq[mm2b4L5JIFkfGm4aYT5JIFo[Wmwc4Sg[JJ2\yC{ZYPpd5RidnRiSE[5M2xZPCClZXzsJI93\XKneIDy[ZN{cW6pIGCt[4x6[2:ycn;0[YlvKHerdHigTWM2OCCxZjCwMlE{PyEQvF2=MX:xNVgxPjd{NR?=
H69PMonIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NHSwNYg1KGR?MoKxTWM2OD1yLkCyO{DPxE1?M2e5Z|EyQDB4N{K1
U251M1HzWGN6fG:2b4jpZ{BCe3OjeR?=MoHpTWM2OD1yLkC5JO69VQ>?NYL0cZN4OTJyM{m1PFg>
UMUC3MXTDfZRwfG:6aXOgRZN{[Xl?NYmzR3Z2UUN3ME2wMlAxQTJizszNMUWxNlM6Ojd{Nx?=
CRL7065NYrp[2xNS3m2b4TvfIlkKEG|c3H5Mlf5OkBlM{\QNWROW09?NIDNPZdKSzVyPUCuOUDPxE1?NFrSc4cyOjR|MUC0PC=>
SKMEL-28NW\1bI84S3m2b4TvfIlkKEG|c3H5M1n6VVYh\A>?M2DNSmROW09?MmrmTWM2OD1yLkC2JO69VQ>?NUj5NmFQOTJ2M{GwOFg>
SK-MES-1M3LKdmN6fG:2b4jpZ{BCe3OjeR?=MXG2JIQ>MmjFSG1UVw>?NGrsdnZKSzVyPUCuNFMh|ryPNVzRcmlFOTJ2M{GwOFg>
Hep-2MlHSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MnHXPVYhcA>?M1LwSGROW09?NILTTGpKSzVyPUCuNFQh|ryPMoiwNVI1OzFyNEm=
RajiM4XHPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MXG5OkBpNHTGcXdFVVORMmPTTWM2OD1yLkCzJO69VQ>?NFq5NJkyOjR|MUC0PS=>
Wil-NSNVm0N2xXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M4KzdFk3KGh?MV\EUXNQMmLVTWM2OD1yLkCyJO69VQ>?Ml;DNVI1OzFyNEm=
2SC/20M3\Zdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MV:3NkBpNEfoOWRl\Wmxbnn6[YQhf2G2ZYK=MWTJR|UxRTBwNkKg{txOMYCxNlQ{OTB4MB?=
HET-SR-2SC-LNMM4nJbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MofFO|IhcA>?MWPk[Ylwdmm8ZXSge4F1\XJ?MYjJR|UxRTBwMEWyJO69VQ>?M1LxUFEzPDNzME[w
L1210M33YW2N6fG:2b4jpZ{BCe3OjeR?=NHXUNnU1QCCqNWHxdYpjTE2VTx?=MonwTWM2OD1yLkCyOUDPxE1?MWWxNlQ1Ozd4Mx?=
LXFL529NYjEc2E3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MmH5N|YhcA>?M2G3cGlEPTB;MD6wOEDPxE1?MlHUNVI1PTlyMkC=
8226/DOX1VM1jocmN6fG:2b4jpZ{BCe3OjeR?=MVi3NkBpMmLtSG1UVw>?M1r4dWN6fG:2b4jpeJkh[WejaX7zeEA5OjJ4L1TPXFFXMYWxNlU4ODN5OB?=
8226/SMorCR5l1d3SxeHnjJGF{e2G7M1v0U|czKGh?NHzBe4tFVVORNIjzdIREgXSxdH;4bZR6KGGpYXnud5QhQDJ{Nj;TM2LjflEzPTdyM{e4
JurkatNYjBR2VLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MWm3NkBpMVfJR|UxRTBwMEC5OkDPxE1?NYew[|NkOTJ4MkCwPFE>
P388NUDH[XpMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NHPFeXM4OiCqNX7GN2M3UUN3ME2wMlAyPSEQvF2=MnLLNVI3OjByOEG=
L2987NW\MUYppS3m2b4TvfIlkKEG|c3H5MnnvTWM2OD1yLkOg{txONGmyT4EyOjd7OEOxOy=>
401NLM3jvTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NX3VZmZrPzJiaB?=MYXEUXNQMnLmTWM2OD1yLkCxJO69VQ>?MWmxNlg2Ojd4OB?=
LXF529LNY\lcnU{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MWi3NkBpNGHjS2lFVVORMnz2TWM2OD1yLkCzJO69VQ>?NWrCVoMxOTJ6NUK3Olg>
LXF629LMW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M1HuRlczKGh?MXHEUXNQNEPtV4ZKSzVyPUCuNFch|ryPMl;vNVI5PTJ5Nki=
RXF944LMVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M{PVOFczKGh?MVLEUXNQM1nvSGlEPTB;MD6wOkDPxE1?MUexNlg2Ojd4OB?=
Neuro2ANFjaeoRHfW6ldHnvckBCe3OjeR?=NXu5flIxOyC3Zz;tUC=>MmLVNlQhcA>?NU[0Unp{VmW3cnn0c4dmdmmlIHHjeIl3cXS7IHHzd4V{e2WmIHHzJI1wenCqb3zv[4lk[WxiY3jhcodmew>?MXWxOFU4PTR2MB?=
HT1080NH7qVHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NY[2ZZk3PzJiaB?=MoDVSG1UVw>?Mlm3TWM2OD1yLkC1PUDPxE1?NEe4cpEyPDZ2MEWxNy=>
H460Moi5R5l1d3SxeHnjJGF{e2G7NWfYOmFDT0l3ME2zMlDjiIoFl,MAjVExNTdizsznM41NNFjoV4cyPDZ2MEWzNi=>
MCF7Mn3RR5l1d3SxeHnjJGF{e2G7MX\HTVUxRThwMPMAjeOY6oDLMUCtO{DPxGdxbVy=MnnxNVQ3PDB3M{K=
SF268MoHaR5l1d3SxeHnjJGF{e2G7MX7HTVUxRThwNfMAjeOY6oDLMUCtO{DPxGdxbVy=MYexOFY1ODV|Mh?=
DuPROM3POT2N6fG:2b4jpZ{BCe3OjeR?=MUjFR|UxRTFwODFOwG0>NV3oZXVEOTR4NkeyNFg>
DU145M{LHWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NEjkW3Q4OiCqM1rOW2ROW09?NVn6dmRrT0l3ME2wMlAzKM7:TR?=M4T4T|E1QTdzOEmz
HeLaM2Hhc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7Mne5O|IhcA>?NYLjS2V3TE2VTx?=NX3CSWhET0l3ME2wMlAyKM7:TR?=MUSxOFk4OTh7Mx?=
IGROVNWm3PFlkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NH3RdHY4OiCqMWDEUXNQM{\wRWdKPTB;ND60JO69VQ>?MlfuNVQ6PzF6OUO=
LNcaPM4GzZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MoXDO|IhcA>?NFzx[2JFVVORM37vbGdKPTB;MD6wNkDPxE1?NILaelkyPDl5MUi5Ny=>
LOVOMnjVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MoD2O|IhcA>?NHSwbI5FVVORM2O0NmdKPTB;MD6wNUDPxE1?NGHvdFEyPDl5MUi5Ny=>
MEL-28M{ixU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NVnNTHFHPzJiaB?=NEO2OGhFVVORMYDHTVUxRTNwMTFOwG0>MWmxOFk4OTh7Mx?=
PANC-1MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?Mlq1O|IhcA>?NU\tfGkyTE2VTx?=MXfHTVUxRTNwNTFOwG0>NELrN5cyPDl5MUi5Ny=>
MDA-MB-435MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NH7jd3Q1KGh?MoT1SG1UVw>?M4CzZ2lEPTB;MD6xOUDPxE1?MmjqNVQ6PzF6OUm=
TRAMP-C2DNWHJS2tOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M2nBUVczKGh?NEXPdYJKSzVyPUCuNFQ3PSEQvF2=MkPBNVQ6PzF7MUC=
TRAMP-C2GNF;aPJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MmX3O|IhcA>?NEfUVVlKSzVyPUCuNFI5PyEQvF2=M{PEXlE1QTdzOUGw
MD-MB468M4\qUmN6fG:2b4jpZ{BCe3OjeR?=NGe2RZE4OiCqM4LPeWlEPTB;MD6wNFch|ryPM3HjXlE1QThyNkey
T47DNHHVVppEgXSxdH;4bYMhSXO|YYm=NWLWfXRPPzJiaB?=NYW2UWR[UUN3ME2wMlAxPyEQvF2=NFvPNmEyPDl6ME[3Ni=>
RPMI8226Ml;HR5l1d3SxeHnjJGF{e2G7NFG4RWs4OiCqMYPJR|UxRTBwMTFOwG0>NHjtfmIyPDl6N{C0PS=>
U937/GTBMV;DfZRwfG:6aXOgRZN{[Xl?MoTqO|IhcA>?MXnJR|UxRTBwMTFOwG0>M{DDTFE1QTh5MES5
Col2NELacWFEgXSxdH;4bYMhSXO|YYm=NH;POlE4OiCqNVfzfXpITE2VTx?=MkTQTWM2OD1yLkWyJO69VQ>?NWjIWHhIOTVzN{e0N|g>
MEL-28NX;zOJpPS3m2b4TvfIlkKEG|c3H5M3r4W2lEPTB;MD6wN{DPxE1?MmHINVUzOjV5MEC=
Rtx6MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M{j4fFQhcA>?NYj5UGRCTE2VTx?=NXTCN4dYT3Kxd4ToJIlvcGmkaYTpc44hd2ZiRWKg[ZhxemW|c3nu[{BTfHh4IHPlcIx{M1;OVFE2PTh6MEi2
WI38NFfNZ3dEgXSxdH;4bYMhSXO|YYm=NHO3dZQ1QCCqMXzEUXNQM4DvXmlEPTB;MD6zJO69VQ>?M3jUeFE2PjJyMkO4
MeVoMXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NU\tc|ZqOjRiaB?=M4LX[pdifGW{M1jlSGlEPTB;MD64NkDPxE1?NIrvNnEyPTdzNUS4NS=>
VA13M{PHU2N6fG:2b4jpZ{BCe3OjeR?=M{fRSVQ5KGh?M17VeGROW09?NFnleopKSzVyPUCuN|gh|ryPNFTIT2MyPTd|MEK0Ny=>
NCI-H69NWnvboRWS3m2b4TvfIlkKEG|c3H5MnX2OkBlMnXLTWM2OD1yLkCxNVMh|ryPNU\HWmpDOTV5NEOxO|g>
HSC-2MUPDfZRwfG:6aXOgRZN{[Xl?MkP1NlQhcA>?MmjBR2M2OD1yLk[4JO69VQ>?M{XzXlE2PzR3OEGy
HSGMn;CR5l1d3SxeHnjJGF{e2G7MmTxNlQhcA>?NYXVN5ZzS0N3ME2xMlkh|ryPMmTpNVU4PDV6MUK=
MES-SANYTRc4t5S3m2b4TvfIlkKEG|c3H5NYPMWmg5UUN3ME2wMlAyPiEQvF2=MmTQNVYyPjl5MUm=
MESSA/DX5MoLTR5l1d3SxeHnjJGF{e2G7NX30T3Y{S3m2b4TvfIlkcXS7IHHnZYlve3RibYXseIllenWpLYLld4l{fGGwdDDNSXMuW0FxRIi1JINmdGy|IIfpeIghUUN3MDDv[kAyNjV4IN88US=>NVvQOo5JOTZzNkm3NVk>
VA13MnXpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NIn4bG41QCCqNEe0UIZFVVORMX3JR|UxRTBwMkKg{txOMnTwNVY1QTl|MkK=
MCF7NW[zO45sTnWwY4Tpc44hSXO|YYm=NV7RXJI5OC53IN88[{9uVA>?MYKyOEBpM3PsS2ROW09?MkXvTY5pcWKrdHnvckBw\iCyNUOtcYVlcWG2ZXSgeJJidnOjY4TpeoF1cW:wNVLlUot7OTZ6NkKxOFE>
5637MkjGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NEX3fJM6PiCqNVLFNnVJTE2VTx?=M4TMb2lEPTB;MD6wNkDPxE1?MUGxOlkyOzdyMB?=
ACHNMlzVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M{jXUFk3KGh?M{X2bmROW09?M{HrfmlEPTB;MD6wNFEh|ryPNFvxWpgyPjlzM{ewNC=>
C8166MnjlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M{ixPFk3KGh?MYrEUXNQNXTrXWNLUUN3ME2wMlAzKM7:TR?=MnzsNVY6OTN5MEC=
G361NYLGRWJ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M2fHVFk3KGh?MUnEUXNQM13SW2lEPTB;MD6wPUDPxE1?MmH1NVY6OTN5MEC=
Wil2-NSNFLBTlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MUi5OkBpM2HwfGROW09?NIHzcmpKSzVyPUCuNFIh|ryPMliwNVY6OTN5MEC=
BCNHLFSGVEgXSxdH;4bYMhSXO|YYm=NVTxUJZWUUN3ME2wMlI5QCEQvF2=Mm\QNVY6OzN6OUC=
HL60/ADRMVfDfZRwfG:6aXOgRZN{[Xl?MkPaNUBuVQ>?MUS3NkBpMl3lSG1UVw>?MWDDfZRwfG:6aXPpeJkh[WejaX7zeEBi\HKrYX35Z4lvNXKnc3nzeIFvfCCKTE[wM2FFWiClZXzsd{BmgHC{ZYPzbY5oKE2UUEGge4l1cCCLQ{WwJI9nKDJizszNM3\WOlE4ODZ7OUO0
HA22TMV;DfZRwfG:6aXOgRZN{[Xl?MV[3NkBpMkLtSG1UVw>?M4rwdmlEPTB;MD6zNUDPxE1?MVixO|ExPzhyNh?=
AGSMnT4R5l1d3SxeHnjJGF{e2G7M2fpRWlEPTB;MD6zNUDPxE1?NX7iN|ZtOTdzMkWyOFA>
H9c2Mm[1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M4\pblI1KGh?NF3xZYxFVVORNFezT29KSzVyPUCuNFE6QTVizszNNH;CWJgyPzF{NUK1Ny=>
SHP77NXGzdYx3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M37wT|I1KGh?NYHXXVR4TE2VTx?=Mk[wTWM2OD1yLkGyOVg6KM7:TR?=NWHuPWtVOTdzMkWyOVM>
SK-HEP-1MmHOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NGj6U2MzPCCqNY[0UVJCTE2VTx?=NVTNVWVTUUN3ME2wMlA2ODF{IN88US=>M2TuSFE4OTJ3MkWz
VeroM2rS[2N6fG:2b4jpZ{BCe3OjeR?=MkmzNlQhcA>?M1PmSWROW09?NFrZWZJKSzVyPUCuOVAyOTlizszNMojLNVcyOjV{NUO=
A2780MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NFWwWXEyKM7:TR?=NYO5OGdOPCCmNXzQPG15TE2VTx?=Ml3HTY5pcWKrdHnvckBw\iClaYPwcIF1cW5vcnXzbZN1[W62IFGyO|gxKGOnbHyg[5Jwf3SqIIfpeIghUUN3MDDv[kAxNjByMzFOwG0>M3rHfFE4OTJ3MkW0
A2780MkfES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NUTiWGpmOSEQvF2=MX:0JIQ>MYfEUXNQMnrzTY5pcWKrdHnvckBw\iCmb4jvdpVjcWOrbj3y[ZNqe3SjboSgRVI4QDBiY3XscEBoem:5dHige4l1cCCLQ{WwJI9nKDBwME[xJO69VQ>?M{DEN|E4OTJ3MkW0
MDA-MB-231MnewR5l1d3SxeHnjJGF{e2G7NXLGNY9OPzJiaB?=M373W2ROW09?MYHJR|UxRTBwMEOg{txONFLjTHUyPzF2MUmyNy=>
MDA435/LCC6M3LDcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NVvoWXltPCCmMUXEUXNQM3nzPWlEPTB;MD6zJO69VQ>?MXuxO|E2PDVyNR?=
K562NWnpRlVvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MVq0PEBpMnnPSG1UVy:vZYToZY5wdA>?MVfJR|UxRTBwMEGg{txOM1fzXFE4OThzMU[0
TRAMP-C1AMXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MVG3NkBpNYfXfVVxf2G2ZYK=MoPiS2k2OD1yLkCyNFQh|ryPNF7Ub4EyPzF6MUG2Oi=>
TRAMP-C2HM4HPcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M1rCUlczKGh?MlrHe4F1\XJ?NHr5[4VIUTVyPUCuNFE2QCEQvF2=M4q0eVE4OThzMU[2
2780ADNXj0Xo1mS3m2b4TvfIlkKEG|c3H5NHHCNJIyOCEQvF2=MoLWR5l1d3SxeHnjbZR6KGGpYXnueEBufWy2aXTyeYcuemW|aYP0ZY51KGi3bXHuJFI4QDCDRDDj[YxteyC5aYToJGlEPTBib3[gNE46ODlizszNM{fDS|E4OjN7NUm3
K562I/S9MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NV\kfYZzPzJiaB?=MVzEUXNQMX3BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKG23bITp[JJ2\y2{ZYPpd5RidnRiS{W2NokwWzliY3XscJMh\XiycnXzd4lv\yCSZ4Cge4l1cCCLQ{WwJI9nKDJizszNMXexO|I4PjZ7MB?=
CEM/VLB100MnTLR5l1d3SxeHnjJGF{e2G7MkS0O|IhcA>?M3:2V2ROW09?NVrHTHM2S3m2b4TvfIlkcXS7IHHnZYlve3RidnnuZoxie3SrbnWtdoV{cXO2YX70JGNGVS:YTFKxNFAh[2WubIOge4l1cCCLQ{WwJI9nKDNwN{Gg{txOMWCxO|MzOzl|OR?=
CEM/VM1MV\DfZRwfG:6aXOgRZN{[Xl?MWC3NkBpMY\EUXNQM3;ZZWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KHSnbnnwc5Nq\GVvcnXzbZN1[W62IFPFUU9XVTFiY3XscJMhf2m2aDDJR|UxKG:oIECuOVUh|ryPNIW0cJYyPzN{M{mzPS=>
MeVoM3HBTmN6fG:2b4jpZ{BCe3OjeR?=M3jXWVQ5KGh?NWfS[YZUf2G2ZYK=NInzZ|hKSzVyPUCuPFIh|ryPMXexO|M4PTlyMh?=
KB-VINNVPzR5ozS3m2b4TvfIlkKEG|c3H5MojmO|IhcA>?Mn\qSG1UVw>?MVTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDteYx1cWS{dXetdoV{cXO2YX70JGtDNV[LTjDj[YxteyC5aYToJGVEPTBib3[gNU44KM7:TR?=Mn\QNVc{Pzh3M{C=
2780ADNVX1[ppLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NIfpS3MyOCEQvF2=NUXmc3o4T3Kxd4ToJIlvcGmkaYTpc44hd2ZibYXseIllenWpLYLld4l{fGGwdDDoeY1idiB{N{iwRWQh[2WubIOge4l1cCCLQ{WwJI9nKDBwMkm4JO69VQ>?NFPTfoUyPzR7MEi3PC=>
BGC823M1fpZmN6fG:2b4jpZ{BCe3OjeR?=M3m0SFQ5KGh?MljHTWM2OD1yLkO1JO69VQ>?NHvCR4MyPzV6M{m1Ny=>
ZR-751M2fJZ2N6fG:2b4jpZ{BCe3OjeR?=MWO3NkBpMmHBSG1UVw>?NXzo[IdCUUN3ME2wMlA1KM7:TR?=NVvJW2I4OTd3OEW3OFc>
1A9MnWwR5l1d3SxeHnjJGF{e2G7NGr2RYlFVVORMnO2SWQ2OD1yLkCyJO69VQ>?M{fL[lE4PTlzNES0
LNcaPMlXSR5l1d3SxeHnjJGF{e2G7NXv4Zo1yTE2VTx?=MmjjSWQ2OD1yLkC0JO69VQ>?NH3jZ3YyPzV7MUS0OC=>
UACC62NGHqTpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NH\ORY81QCCqMXXEUXNQM2r0NWdKPTB;MD6wPVQh|ryPMXGxO|YyPDJ7Mh?=
DLD1NGnFXWlEgXSxdH;4bYMhSXO|YYm=MXG3NkBpMV\JR|UxRTBwMTFOwG0>NIHkSGwyPzZ3NkC5NS=>
UO31NEizTpFEgXSxdH;4bYMhSXO|YYm=NGPrNHA4OiCqMknVTWM2OD1yLkGg{txOMXmxO|Y2PjB7MR?=
PC3NViyfWhjTnWwY4Tpc44hSXO|YYm=MV:yNEBvVQ>?MXy3NkBpNXLYcXlKUW6mdXP0bY9vKG:oIIPlcoV{[2WwY3WgbY4hcHWvYX6gVGM{KGOnbHzzMn\3NVc3PTh5N{e=
BxPc3NF;G[2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M2LqfFMhcA>?MWrJR|UxRTBwM{G2NlMh|ryPNYTse3BQOTd4OU[1NVY>
IGROVIMWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MYS0PEBpMYHJR|UxRTBwMUC5OlUh|ryPMnmzNVc3QTZ3MU[=
RXF393MkDlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MVe0PEBpNEPLSoNKSzVyPUCuNVc4QDNizszNMW[xO|Y6PjVzNh?=
UACC257MlOyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MkPMOFghcA>?MlzTTWM2OD1yLkKwPFk{KM7:TR?=MV[xO|Y6PjVzNh?=
MIAPaCa2NVH1VGx6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M{npV|ExOCEQvF2=MnHqO|IhcA>?NIjIPI9KSzVyPUCuNFI1KM7:TR?=M2Lj[|E4QTN3M{C5
WI38NX;mXmtST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NGPYcpkyODBizszNNVTqbHcxPzJiaB?=MofxTWM2OD1yLkGg{txOM4DQWVE4QTN3M{C5
KB3.1MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MkTiNVAxKM7:TR?=NH3ufWY4OiCqNWfocoE2TE2VTx?=NHTSOohKSzVyPUCuNFAxPCEQvF2=NGHnO4syPzl2OUi1PS=>
MCF7NILhNo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M2LENVExOCEQvF2=Mn\uO|IhcA>?MX;EUXNQM1TDdWlEPTB;MD6wNFA4KM7:TR?=NWnJS5Y6OTd7NEm4OVk>
2780.9SNITuSGZEgXSxdH;4bYMhSXO|YYm=M4[0fVExOCEQvF2=MknwPVYhcA>?MYnDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjCyO|gxNjmVIHPlcIx{KHWwZHXyJIRm\W1ibHnnbJQhf2m2aDDJR|UxKG:oIEG1JO69VQ>?MmrhNVc6QTN{N{W=
DaudiMXTDfZRwfG:6aXOgRZN{[Xl?NX\wSGdWOTByIN88US=>NVjX[YVnQTZiaB?=M{TpT2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGRifWSrIHPlcIx{KHWwZHXyJIRm\W1ibHnnbJQhf2m2aDDJR|UxKG:oIECuN{DPxE1?M{fH[lE4QTl|Mke1
W301MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M4PnSFUxKG2PNIjBfJc1QCCqMYnEUXNQNVPHVWhuT3Kxd4ToJIlvcGmkaYTpc44hd2ZiU3HjZ4hiem:veXPld{Bk\XKndnnzbYFmKFd|MEGge4l1cCCLQ{WwJI9nKDFyIN88US=>Mn[3NVgxPDByNEO=
SF268MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M{XrVFczKGh?MWTEUXNQNWfzPYREUUN3ME2wMlA1KM7:TR?=Mn\rNVgxPTJ|Mk[=
SNU638MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MWS3NkBpNGXzc3hKSzVyPUCuNFch|ryPNH3U[FgyQDB4M{O2Oi=>
U373MGMUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NYPIWGpuOjRiaB?=M3;YZWROW09?MYLHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDVN|c{VUdiY3XscJMh[2:wdHHpcolv\yCXM{ezTXJGWyCybHHzcYllKHerdHigTWM2OCCxZjCwMlE2QDR7IN88US=>MkfkNVgyPzN{M{O=
U373MGNILGO|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NVrJR5M4OjRiaB?=NIrCOnJFVVORMYfHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDVN|c{VUdiY3XscJMh[2:wdHHpcolv\yCXaFPFNUBmgHC{ZYPzbY5oKHCuYYPtbYQhf2m2aDDJR|UxKG:oIECuNVU5PDlizszNNHLFRoEyQDF5M{KzNy=>
U373MGNF\YcVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M3LJZVI1KGh?M{HmU2ROW09?NFPvdZlIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBWOzd|TVegZ4VtdHNiY3;ueIFqdmmwZzDVbIlETSCneIDy[ZN{cW6pIIDsZZNucWRid3n0bEBKSzVyIH;mJFAvOTl7NUOg{txOM{Ln[FE5OTd|MkOz
HepG2NV7iSpExS3m2b4TvfIlkKEG|c3H5MYGxNFAh|ryPNE\leFQ4OiCqMVjJR|UxRTBwMEeg{txOMkL3NVgyQDF3N{W=
SJSA1NXzOVo1kS3m2b4TvfIlkKEG|c3H5NVv3WIdVOSEQvF2=NVX5Xo1HPiCqNV31VYJUS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hW0qVQUGgZ4VtdHNiZYjwdoV{e2mwZzDHVnA4QCC5aYToJGlEPTBib3[gNE4xODZ{IN88US=>MVSxPFI1OzZ7Nh?=
PC3MNXjpWWM4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MWi3NkBpMWrEUXNQNULnSYo5UUN3ME2xMlEyKM7:TR?=MYWxPFI1PzV5Mx?=
K/VP.5NHyxN2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MnHIO|IhcA>?NEX0S3lFVVORM1viXmdzd3e2aDDpcohq[mm2aX;uJI9nKGW2b4Dvd4ll\S2{ZYPpd5RidnRiaIXtZY4hUy:YUD61JINmdGy|IIfpeIghUUN3MDDv[kAxNjRzIN88US=>MWWxPFI2QDR2Mh?=
A375NWfVcZRWS3m2b4TvfIlkKEG|c3H5M3TNTFI1KGh?NX7BU|hSTE2VTx?=M3vGb2lEPTB;MD6wNUDPxE1?MUixPFI5OTF{NR?=
Hep2M2\qbWN6fG:2b4jpZ{BCe3OjeR?=MYCyOEBpM{XhU2ROW09?NWroU4NDUUN3ME2wMlQzKM7:TR?=NH;XUHoyQDJ6MUGyOS=>
HT1080Mle3R5l1d3SxeHnjJGF{e2G7NHn0N3A4OiCqMlqySG1UVw>?NYfIb45FUUN3ME2wMlAzOiEQvF2=M{f0UFE5OzJzN{G1
SNU638NFHFdJhEgXSxdH;4bYMhSXO|YYm=NU\4UpZjPzJiaB?=NHGycVFFVVORMX;JR|UxRTBwMEWyJO69VQ>?NVHOW5RZOTh|MkG3NVU>
Caco2MljiSpVv[3Srb36gRZN{[Xl?M2rSZ|UxKG6PMnvlOFghcA>?M4WyepdifGW{M2TJfWRm[3KnYYPlJIlvKGO7Y3zpckBCKGW6cILld5Nqd25?NWXtZo5KOTh2Mkm2NVA>
MCF7/DXNHPNPWlEgXSxdH;4bYMhSXO|YYm=NEDFZoszPCCqNUP1RlAyf2G2ZYK=MkDKR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6g[I95d3K3YnnjbY4uemW|aYP0ZY51KE2FRkevSJgh[2WubIOge4l1cCCLQ{WwJI9nKDVwMzFOwG0>MXSxPFQzQTZzMB?=
Colon 26-L5MYrDfZRwfG:6aXOgRZN{[Xl?M2L4eVczKGh?MlXMSG1UVw>?NEfpeWtKSzVyPUCuNFEh|ryPMUmxPFQ1ODJ|Mx?=
LLCNFTtXIxEgXSxdH;4bYMhSXO|YYm=NIPiXZY4OiCqMofKSG1UVw>?M1Lrd2lEPTB;MD6wNUDPxE1?M3v0dlE5PDRyMkOz
L1210MUHGeY5kfGmxbjDBd5NigQ>?NUHmSHJuOC53IN88[{9uVA>?NWCxR2F[OTJiaB?=MUH3ZZRmeg>?MmjGR4VtdCCleXPs[UBienKnc4SgbY4hdW:3c3WgUFEzOTBiY3XscJMh[nliYXPjeY12dGG2aX;uJIF1KEd{L12gdIhie2V?NF[2PZIyQDVyOEK3Ny=>
SK-MEL-2NWW2O3p1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MVG3NkBpNXmwT3AxT0l3ME2wMlEyKM7:TR?=M{fkWVE5PTh3MEO1
AW13516MkL2R5l1d3SxeHnjJGF{e2G7NIrPRnAyODBizszNMl3QOFghcA>?NI\6W|hIUTVyPUCuNUDPxE1?NGO2R3oyQDZ3N{m3PS=>
AW8507MoHGR5l1d3SxeHnjJGF{e2G7NUPoSXl7OTByIN88US=>NUjrfW1bPDhiaB?=M33sU2dKPTB;MD6xO{DPxE1?MoL4NVg3PTd7N{m=
JurkatMXzDfZRwfG:6aXOgRZN{[Xl?NWjaS|JIPzJiaB?=MmDtTWM2OD1yLkCzJO69VQ>?M{fhb|E5Pzh|OUWw
MRC5Mk[1R5l1d3SxeHnjJGF{e2G7M1T2TlczKGh?NWnDflVmUUN3ME2wMlEh|ryPMXqxPFc5Ozl3MB?=
DU145NGPyOZVEgXSxdH;4bYMhSXO|YYm=NX\UcYZMOjVizsznM41NM2LDfVczKGh?M4PPZ2lEPTB;MD6wNFM6KM7:TR?=NWPSWFJTOTh6MkmzNVY>
Bel7402NXXDS|dWS3m2b4TvfIlkKEG|c3H5MmP4O|IhcA>?NF\O[2tFVVORMUTJR|UxRTBwMEKxJO69VQ>?NE\NfY8yQTB{OESyOS=>
HT-29MV\DfZRwfG:6aXOgRZN{[Xl?MYS3NkBpMknTSG1UVw>?MX7JR|UxRTBwMEG4JO69VQ>?M2PVV|E6ODJ6NEK1
HT-29NX7ab|Z4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M{O5[lk3KGh?NWTqe3c5TE2VTx?=M2\2PGlEPTB;MD6wNFIh|ryPNEfPVIIyQTB3M{e2Oy=>
MT4NIT6XlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NVq3TGlsQTZiaB?=MlSxSG1UVw>?NIXHfW5KSzVyPUCuNFA{KM7:TR?=NXPxNJFEOTlyNUO3Olc>
XF498MkTiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NFfxcpU6PiCqNHTPeFJFVVORMYnJR|UxRTBwMU[g{txONUPK[3czOTlyNUO3Olc>
A2780/DX3NV\MNZZXTnWwY4Tpc44hSXO|YYm=MXOxNEDPxE1?M4rIeFIhcA>?NVi3enNMe2GuaX7lNGfYdG5T\X[ncoPhcEBw\iCSLXfwJFE4OC2vZXTpZZRm\CCvdXz0bYRzfWdicnXzbZN1[W6lZTDhd5Nme3OnZDDhd{BqdmO{ZXHz[UBqdiCrboTyZYNmdGy3bHHyJIRwgG:{dXLpZ4lvKGGlY4XteYxifGmxbh?=NV7qTJBDOTlyOUO4PFM>
HL60MVjDfZRwfG:6aXOgRZN{[Xl?NYnnS4lCOTByIN88US=>NYDGbIszPzJiaB?=M2DFVmROW09?M3fPTmlEPTB;MD6wNVgh|ryPMlPuNVkyOzZ{NkO=
Hs888LuMXTDfZRwfG:6aXOgRZN{[Xl?NVnWUI5TPzJiaB?=NX\wUYZZUUN3ME2xMlQh|ryPMmTGNVkyQDZ7NE[=
MEFM3vnW2N6fG:2b4jpZ{BCe3OjeR?=NEXod3E4OiCqM1fSZmlEPTB;Mz60JO69VQ>?NYTTbW9{OTlzOE[5OFY>
SNU398MmP4RZBweHSxc3nzJGF{e2G7MoLwNVAh|ryPNEixWGo1QCCqNGf0TG1FVVORMYXJcoR2[3Srb36gc4Yh[XCxcITvd4l{KGG|c3Xzd4VlKGG|IHPhd5Bie2ViYXP0bZZifGmxbjD3bZRpKEWFNUCgc4YhOC5|OTFOwG0>MVSxPVI5OjF6OB?=
T47DMn\1RZBweHSxc3nzJGF{e2G7MmLuNVAh|ryPMVi0PEBpMnjpSG1UVw>?MXHJcoR2[3Srb36gc4Yh[XCxcITvd4l{KGG|c3Xzd4VlKGG|IHPhd5Bie2ViYXP0bZZifGmxbjD3bZRpKEWFNUCgc4YhOC53NzFOwG0>MY[xPVI5OjF6OB?=
SMMC-7541M2PZ[2N6fG:2b4jpZ{BCe3OjeR?=M1TyR|czKGh?MX;JR|UxRTBwMECzO{DPxE1?NEPWbmMyQTJ6NUi2Ny=>
NH32NV\1SZFTSXCxcITvd4l{KEG|c3H5NVzsR3RlOC5zIN88US=>MXe4JIg>Ml7RTY5lfWO2aX;uJI9nKGGyb4D0c5NqeyCrbjDwOVMh\GWoaXPp[Y51KGi3bXHuJG5JOzJiY3XscJMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gZ4xm[X[nZDDjZZNx[XOnIEOgcIV3\Wx?NXHqPYNNOTl|NEmxO|Q>
NH32NEjYR5RCeG:ydH;zbZMhSXO|YYm=M2D0dlAvOSEQvF2=NHm1cFk5KGh?M3vi[2lv\HWldHnvckBw\iCjcH;weI9{cXNiaX6gdFU{KGSnZnnjbYVvfCCqdX3hckBPUDN{IHPlcIx{KGG|c3Xzd4VlKGG|IHTlZ5Jm[XOnIHnuJJBzdy2lYYPwZZNmKDNibHX2[Yw>Ml7ENVk{PDlzN{S=
NH32M3e1e2Fxd3C2b4Ppd{BCe3OjeR?=NVLDcYc6OC5zIN88US=>NHvCV4c5KGh?NFe2dohKdmS3Y4Tpc44hd2ZiYYDvdJRwe2m|IHnuJJA2OyCmZX\pZ4lmdnRiaIXtZY4hVkh|MjDj[YxteyCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDpckBRSVKSIHPs[YF3[WenNXHjZppjOTl|NEmxO|Q>
NH32NIW4UnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=Ml7aNE4yKM7:TR?=NUn6SY5pPzJiaB?=NXjheIJsS2WubDDjfYNt\SCjcoLld5QhcW5icEWzJIRm\mmlaXXueEBpfW2jbjDOTFMzKGOnbHzzJIF{e2W|c3XkJIF{KGGlY4XteYxifGmxbjDheEB{fWJvR{CvS|EheGijc3W=NFrEUZcyQTN2OUG3OC=>
TK6M1rNPWZ2dmO2aX;uJGF{e2G7MYOwMlEh|ryPMk\CPEBpMoLUTY5lfWO2aX;uJI9nKHB3MzDwbI9{eGixconsZZRqd25iYYSgV4VzOTViaX6gbJVu[W5iVFu2JINmdGy|IHX4dJJme3Orbnege4lt\CC2eYDlJJA2Ow>?MV[xPVM1QTF5NB?=
TK6MnPuSpVv[3Srb36gRZN{[Xl?NFHaT4IxNjFizszNM1u3blghcA>?NV3YOJd6UW6mdXP0bY9vKG:oIIC1N{B1emGwc3PybZB1cW:wYXygZYN1cX[rdImgbY4hcHWvYX6gWGs3KGOnbHzzJIV5eHKnc4Ppcochf2muZDD0fZBmKHB3MzDhd5Nme3OnZDDhd{BxOjFvQ3nwNU9Y[WZzIHX4dJJme3Orb36=NHzWU4gyQTN2OUG3OC=>
TK6NFzYcWJCeG:ydH;zbZMhSXO|YYm=M3XUdFAvOSEQvF2=MXq4JIg>M2PSemlv\HWldHnvckBw\iCjcH;weI9{cXNiaX6gbJVu[W5iVFu2JINmdGy|IHX4dJJme3Orbnege4lt\CC2eYDlJJA2OyCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDpckBkdGWjdnXkJINie3Cjc3WgN{Bt\X[nbB?=M4XBUVE6OzR7MUe0
TK6NUjFbZluSXCxcITvd4l{KEG|c3H5NVjYNG1oOC5zIN88US=>MVq4JIg>MoO0TY5lfWO2aX;uJI9nKGGyb4D0c5NqeyCrbjDoeY1idiCWS{[gZ4VtdHNiZYjwdoV{e2mwZzD3bYxlKHS7cHWgdFU{KGG|c3Xzd4VlKGG|IHTlZ5Jm[XOnIHnuJJBzdy2lYYPwZZNmKDNibHX2[Yw>MnrPNVk{PDlzN{S=
TK6Ml;4RZBweHSxc3nzJGF{e2G7NWfYSoR1OC5zIN88US=>NILPVWw5KGh?Mkn1TY5lfWO2aX;uJI9nKGGyb4D0c5NqeyCrbjDoeY1idiCWS{[gZ4VtdHNiZYjwdoV{e2mwZzD3bYxlKHS7cHWgdFU{KGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJHBCWlBiY3zlZZZi\2V?NUfx[GtvOTl|NEmxO|Q>
TK6MnvlSpVv[3Srb36gRZN{[Xl?NX;RfmhKOC5zIN88US=>MX[3NkBpM{jmZWNmdGxiY4njcIUh[XK{ZYP0JIlvKGi3bXHuJHRMPiClZXzsd{BmgHC{ZYPzbY5oKHerbHSgeJlx\SCyNUOgZZN{\XO|ZXSgZZMh[WOldX31cIF1cW:wIHH0JJN2[i2JMD;HNUBxcGG|ZR?=MnX1NVk{PDlzN{S=
TK6MkPHSpVv[3Srb36gRZN{[Xl?NFjXXFIzPSEQvF2=MljLPEBpNFG4d45KdmS3Y4Tpc44hd2ZicEWzJJBpd3OyaH;yfYxifGmxbjDheEBU\XJzNTDpckBpfW2jbjDUT|Yh[2WubIOg[ZhxemW|c3nu[{B4cWymIIT5dIUheDV|NWTk[ohEOTl|NEmxO|Q>
TK6MXjGeY5kfGmxbjDBd5NigQ>?M2Tp[|I2KM7:TR?=NU\6R|U1QCCqM1LTPWlv\HWldHnvckBw\iCyNUOgeJJidnOlcnnweIlwdmGuIHHjeIl3cXS7IHnuJIh2dWGwIGTLOkBk\WyuczDlfJBz\XO|aX7nJJdqdGRidInw[UBxPTNiYYPz[ZN{\WRiYYOgdFIyNUOrcEGvW4FnOSCneIDy[ZN{cW:wMV6xPVM1QTF5NB?=
WTK1MUHGeY5kfGmxbjDBd5NigQ>?M3m1R|AvOSEQvF2=NHP5O3o5KGh?NF6yZWxKdmS3Y4Tpc44hd2ZicEWzJJBpd3OyaH;yfYxifGmxbjDheEBU\XJzNTDpckBpfW2jbjDXWGsyKGOnbHzzJIV5eHKnc4PpcocheDV|IF2yN|dKKG23dHHueC=>M4HlT|E6OzR7MUe0
WTK1MkjnRZBweHSxc3nzJGF{e2G7NXfLTlBJOC5zIN88US=>NHHxfJk5KGh?MV7JcoR2[3Srb36gc4Yh[XCxcITvd4l{KGmwIHj1cYFvKFeWS{GgZ4VtdHNiZYjwdoV{e2mwZzDwOVMhVTJ|N1mgcZV1[W62IHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKGOuZXH2[YQh[2G|cHHz[UA{KGyndnXsMknpNVk{PDlzN{S=
WTK1NU\3fVVOSXCxcITvd4l{KEG|c3H5M2\qbFAvOSEQvF2=NWXpd2s6QCCqM2T6VGlv\HWldHnvckBw\iCjcH;weI9{cXNiaX6gbJVu[W5iV2TLNUBk\WyuczDlfJBz\XO|aX7nJJA2OyCPMkO3TUBufXSjboSgZZN{\XO|ZXSgZZMh\GWlcnXhd4UhcW5icILvMYNie3Cjc3WgN{Bt\X[nbB?=NHPEUHoyQTN2OUG3OC=>
WTK1MV7BdI9xfG:|aYOgRZN{[Xl?MYWwMlEh|ryPNXjjNHpYQCCqMYPJcoR2[3Srb36gc4Yh[XCxcITvd4l{KGmwIHj1cYFvKFeWS{GgZ4VtdHNiZYjwdoV{e2mwZzDwOVMhVTJ|N1mgcZV1[W62IHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKFCDUmCgZ4xm[X[jZ3W=MmT3NVk{PDlzN{S=
WTK1MnmySpVv[3Srb36gRZN{[Xl?MVSwMlEh|ryPNVHJ[lVlQCCqNEW1VmlKdmS3Y4Tpc44hd2ZicEWzJJRz[W6|Y4LpdJRqd26jbDDhZ5Rqfmm2eTDpckBpfW2jbjDXWGsyKGOnbHzzJIV5eHKnc4PpcocheDV|IF2yN|dKKG23dHHueEBie3Onc4Pl[EBieyCyMkGtR4lxOS:ZYX[xJIV5eHKnc4Ppc44>M4G5cFE6OzR7MUe0
WTK1MnLZSpVv[3Srb36gRZN{[Xl?MWSyOUDPxE1?M3zKSFghcA>?MnPtTY5lfWO2aX;uJI9nKHB3MzDwbI9{eGixconsZZRqd25iYYSgV4VzOTViaX6gbJVu[W5iV2TLNUBk\WyuczDlfJBz\XO|aX7nJJA2OyCPMkO3TUBufXSjboS=NGfrNYoyQTN2OUG3OC=>
WTK1NXjWUHoyTnWwY4Tpc44hSXO|YYm=NEDl[mgzPSEQvF2=M{HkTVghcA>?M3HU[mlv\HWldHnvckBw\iCyNUOgeJJidnOlcnnweIlwdmGuIHHjeIl3cXS7IHnuJIh2dWGwIGfUT|Eh[2WubIOg[ZhxemW|c3nu[{BxPTNiTUKzO2khdXW2YX70JIF{e2W|c3XkJIF{KHB{MT3DbZAyN1ejZkGg[ZhxemW|c3nvci=>M3XaNVE6OzR7MUe0
WTK1NEnSUWVHfW6ldHnvckBCe3OjeR?=M4S3U|AvOSEQvF2=NW\4Xm1{PzJiaB?=MlLyR4VtdCCleXPs[UBienKnc4SgbY4hcHWvYX6gW3RMOSClZXzsd{BmgHC{ZYPzbY5oKHB3MzDNNlM4USCvdYThcpQh[XO|ZYPz[YQh[XNiYXPjeY12dGG2aX;uJIF1KHO3Yj3HNE9IOSCyaHHz[S=>NWLEUXFmOTl|NEmxO|Q>
ECV304M1nIemN6fG:2b4jpZ{BCe3OjeR?=MWKxNEDPxE1?NUP0RpVqPzJiaB?=M4XPZmN6fG:2b4jpZ4l1gQ>?NV:1WnRSOTl|NkG4PVQ>
HBL100M3PUN2N6fG:2b4jpZ{BCe3OjeR?=Ml7kNVAh|ryPMWi3NkBpMYXJR|UxRTBwMkSg{txONF[4bYcyQTN4MUi5OC=>
PA1NUKyU3VxS3m2b4TvfIlkKEG|c3H5NFu0WnEyOCEQvF2=MlfzO|IhcA>?MX\JR|UxRTBwNkOg{txONEnXUlgyQTN4MUi5OC=>
A431MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M1PCPGdKPTB;MD6wNFEzKM7:TR?=NXTnXHlKOTl|OUSyNVg>
A549NFzYXWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M2jWVWdKPTB;MD6wNFMh|ryPNIPDOoMyQTN7NEKxPC=>
MESSAMYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NH3pNFJIUTVyPUCuNFA2OSEQvF2=M1v2fVE6Ozl2MkG4
SKOV3M4GxPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M2jMRWdKPTB;MD6wNlEh|ryPMkezNVk{QTR{MUi=
U251NUjjRm0zTnWwY4Tpc44hSXO|YYm=M1\yUFEh|ryPNWi2eVVuOTZiaB?=NWexcFZRTE2VTx?=NVLlUVdqUW6qaXLpeIlwdiCxZjDITWYyKGGldHn2ZZRqd25iaX6gbJVu[W5iVUK1NUBk\WyuczDzeIFjdHlidILhcpNn\WO2ZXSgbY4heEeOMj3UT{1JWkVicHzhd41q\CC5aYToJGVEPTBib3[gNE4yOiEQvF2=NGXwXYwyQTRyNUWwPC=>
MDA-MB-231NFrBdW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MX6yNFAh|ryPNV\uU3ZKPDhiaB?=MoPtSG1UVw>?MkDTRY51cXS3bX;yJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iZYP0do9o\W5icnXj[ZB1d3JiZHXmbYNq\W62IF3ERU1OSi1{M{GgZ4VtdHNid3n0bEBIUTVyIH;mJFAvODFyOE[g{txOMWexPVQzQDF3NR?=
SNU1NV31UI97S3m2b4TvfIlkKEG|c3H5NV;wVIpXUUN3ME20JO69VQ>?MlvLNVk2QDV7OUi=
SK-N-SHNIDuVlNCeG:ydH;zbZMhSXO|YYm=M1fCZVUh|ryPMn\TTY5lfWO2aX;uJI9nKGGyb4D0c5NqeyCjdDCwMlUhfG9iNTD1US=>M4TyNFE6PjNzNUS5
SK-N-SHMWnBdI9xfG:|aYOgRZN{[Xl?M33q[lUh|ryPMUHJcoR2[3Srb36gc4Yh[XCxcITvd4l{KGG|c3Xzd4VlKGG|IHPhd5Bie2ViMzDhZ5Rqfmm2eR?=NYm3ToZmOTl4M{G1OFk>
IMR90NYrU[pJlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M13me|czKGh?Mo\tSG1UVw>?NWTMcGFwUUN3ME2xJO69VQ>?Mme0NVk3OzJ6M{O=
L78MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MnPhO|IhcA>?NHvpTINFVVORNH3qcVBKSzVyPUKuOEDPxE1?MmnxNVk3OzJ6M{O=
MOLT4MmDQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MXu3NkBpNIfJbXJFVVORNIr6ZY1KSzVyPUCuNFAzKM7:TR?=NYnkdmw5OTl4M{K4N|M>
OS-RC2NFfDdmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MUG3NkBpMmPISG1UVw>?M2Szb2lEPTB;NT60JO69VQ>?NHXROoUyQTZ|MkizNy=>
U251MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MYe3NkBpMoLTSG1UVw>?M4XQbWlEPTB;MD62JO69VQ>?NYfiXoF2OTl4M{K4N|M>
HCT116MXvDfZRwfG:6aXOgRZN{[Xl?MlfiO|IhcA>?NYew[ZBoTE2VTx?=MWLJR|UxRTBwMEC2JO69VQ>?MlTlNVk3PTV5NkK=
KBMkjBR5l1d3SxeHnjJGF{e2G7MVu3NkBpNWG0e3BITE2VTx?=MmX1TWM2OD1yLkCwNUDPxE1?M4HuZ|E6PjV3N{[y
B16-BL6MWPDfZRwfG:6aXOgRZN{[Xl?M1vQOlczKGh?MYfEUXNQMl31TWM2OD1|LkC3JO69VQ>?NHO4c20yQTZ6OUGyOS=>
Colon 26-L5M1nBfGN6fG:2b4jpZ{BCe3OjeR?=MnflO|IhcA>?NIr3UYZFVVORNESwRplKSzVyPUOuNVIh|ryPM1jKXFE6Pjh7MUK1
2008/MRP1NFnoVXFEgXSxdH;4bYMhSXO|YYm=NH60U2g2KGR?NYPqdJNCTE2VTx?=NEC5U21KSzVyPUCuOVc4KM7:TR?=M1;LflE6PzJ3NUe4
2008/PNE\jZ3NEgXSxdH;4bYMhSXO|YYm=MXq1JIQ>Mn;wSG1UVw>?M4DoUWlEPTB;MD6wOlMh|ryPMYixPVczPTV5OB?=
HL60/MX2MkjSR5l1d3SxeHnjJGF{e2G7MknOOFghcA>?MofrSG1UVw>?NEG1XHBKSzVyPUiuNFQ3KM7:TR?=MUOxPVc1Ozh3OB?=
MDA-MB-453MUfDfZRwfG:6aXOgRZN{[Xl?NVr3Wm9POC53ODFOwIcwdUx?NGrkblg3QSCqNELoRZpFVVORM{[wVGlEPTB;MD6xNkDPxE1?NXjKPXdpOTl5OEiyPVA>
HCT15MkLsR5l1d3SxeHnjJGF{e2G7M1HkZWlEPTB;MD6wN|ch|ryPMW[xPVgyQTZ7Nh?=
HuCCa1NEj5TmJEgXSxdH;4bYMhSXO|YYm=NFPONVI1KGR?MYfJR|UxRTBwNkSg{txONGXSe3gyQTh{NE[xPC=>
MOLT3NWrmPIlJS3m2b4TvfIlkKEG|c3H5MVzJR|UxRTBwMESg{txOMmS2NVk5OjR4MUi=
IMR32M2XRXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NWj0R2pzPDhiaB?=NX3BSINrTE2VTx?=NFHBTmtKSzVyPUGuO{DPxE1?NV\ESHpKOTl7M{m1NlI>
MCF10AM17EWGN6fG:2b4jpZ{BCe3OjeR?=Ml7iOFAh|ryPM{Dxc|Q5KGh?NGPHSXNFVVORNGfJbFdKSzVyPUCuNVgh|ryPNYHhS45iOjByNkS2O|Y>
MESSAM{LvUGZ2dmO2aX;uJGF{e2G7MVO1NEDPxE1?NVjmeVc4OiCqNYDaSFVRf2G2ZYK=NVfhU|MzUW6mdXP0bY9vKG:oIFTORUBl[W2jZ3WgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iY3;t[ZQufGGrbDDs[Y5ofGh?MlHLNlAyPTF4M{m=
MESSAMl[4SpVv[3Srb36gRZN{[Xl?Mle2NlUh|ryPMoK5NkBpNFPyNHB4[XSnch?=MXzD[YxtfWyjcjD1dJRic2V?NUTOVmJtOjBzNUG2N|k>
MESSA/DX5MkTrSpVv[3Srb36gRZN{[Xl?MWG1NEDPxE1?MXiyJIg>NGXoT4F4[XSnch?=NHvYXo9KdmS3Y4Tpc44hd2ZiRF7BJIRidWGpZTDhd5Nme3OnZDDhd{BqdmO{ZXHz[UBqdiClb33leE11[WmuIHzlcod1cA>?MYOyNFE2OTZ|OR?=
SKHepNGXWd4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NV;jRmpZPDhiaB?=M2PTZmROW09?MXXJR|UxRTBwMEmg{txONIL6bGczODF5MUGwPC=>
MIAPaCa2NHzPc4lEgXSxdH;4bYMhSXO|YYm=M3PHR|ExOCEQvF2=NUHLTolWPzJiaB?=NH\TVY1KSzVyPUCuNFEh|ryPM4LpUFIxOjB5MES5
SKHEP1NF\IeplEgXSxdH;4bYMhSXO|YYm=MkL5OFghcA>?NGPWdZFKSzVyPUCuNFEh|ryPMofKNlAzOTB|NE[=
U87MGMUPDfZRwfG:6aXOgRZN{[Xl?NVzFeIdKPDhiaB?=MXHJR|UxRTBwMEG4JO69VQ>?NILVdY0zODJzMEO0Oi=>
SK-N-MCMX7DfZRwfG:6aXOgRZN{[Xl?NYHvc3lHPzJiaB?=NUDPeGMyUUN3ME2wMlEzKM7:TR?=MofFNlA{ODN5Nki=
GOTONFLYfnNEgXSxdH;4bYMhSXO|YYm=M{O1c|czKGh?M2roTmlEPTB;MD6wNFQ4OyEQvF2=NGTReJczODN3Nk[1OS=>
HL60MXXDfZRwfG:6aXOgRZN{[Xl?NYrON4U{PzJiaB?=M2XMcGlEPTB;MD6wNFEyOyEQvF2=MYqyNFM2PjZ3NR?=
K562MYDDfZRwfG:6aXOgRZN{[Xl?NUDTNoZFPzJiaB?=NWXSb2Z7UUN3ME2wMlAxPjF{IN88US=>NYCxe2NUOjB|NU[2OVU>
NB-1MWfDfZRwfG:6aXOgRZN{[Xl?MoW5O|IhcA>?NGDSeZhKSzVyPUCuNFA2OTVizszNM3zNbVIxOzV4NkW1
U937Ml3oR5l1d3SxeHnjJGF{e2G7M2rTNVczKGh?NEPxW21KSzVyPUCuNFA1PDVizszNM{HveVIxOzV4NkW1
HBI10AMUHDfZRwfG:6aXOgRZN{[Xl?MlXtR2M2ODxyLkOg{txONEXGOXIzODN4M{G0NC=>
3T3M3vNUWN6fG:2b4jpZ{BCe3OjeR?=M3zRVVExKM7:TR?=NUDCN2tmPDhiaB?=M1;Be2lEPTB;Mz63JO69VQ>?NUTZbpRWOjB2MEW4OFQ>
NCI/ADRM{WycWN6fG:2b4jpZ{BCe3OjeR?=M322elI2OCEQvHevcWw>NGnwOmg1QCCqNY\pTZVUT0l3ME21Mlk6KM7:TR?=MVWyNFQyOzF6OB?=
OVCAR-3NUHQ[XA2S3m2b4TvfIlkKEG|c3H5MmLtNlUxKM7:Zz;tUC=>M2qzSlQ5KGh?NGi4RnRIUTVyPUCuNFch|ryPM13jN|IxPDF|MUi4
PCO3NV[yV4dYS3m2b4TvfIlkKEG|c3H5M4S5XFI2OCEQvHevcWw>MWq0PEBpMX\HTVUxRTBwMUeg{txONHnVe2ozODRzM{G4PC=>
CEM/ADR5000M{i2cGFxd3C2b4Ppd{BCe3OjeR?=NIi2cWoyKM7:Zz;tUC=>NYfsfFc2OjRiaB?=M4PpeWlv\HWldHnvckBw\iCjcH;weI9{cXN?MX[yNFUzPzlzNx?=
CEM/ADR5000M1\YVWZ2dmO2aX;uJGF{e2G7NWn6[YZqOSEQvHevcWw>MXK2JIg>NGDS[nJKdmO{ZXHz[UBqdiCUT2Og[4Vv\XKjdHnvci=>NV[0SpBLOjB3Mke5NVc>
GXF251LNUmybZJyS3m2b4TvfIlkKEG|c3H5NHLmbFgyOCEQvF2=NFe0SG8zPCCqMX;JR|UxRTBwMEWyJO69VQ>?NUTlbWxDOjB3NEWzN|Q>
MAXF401NLNXPXSJNnS3m2b4TvfIlkKEG|c3H5M3\me|ExKM7:TR?=NHewNpUzPCCqM3nTeGlEPTB;MD6wOVIh|ryPMUiyNFU1PTN|NB?=
MEXF462NLNFXiWYxEgXSxdH;4bYMhSXO|YYm=NVvDV3ZrOTBizszNM3G3NVI1KGh?MUjJR|UxRTBwMEWyJO69VQ>?MkPONlA2PDV|M{S=
PAXF1657LMXXDfZRwfG:6aXOgRZN{[Xl?M2XVWlExKM7:TR?=NH\DT4EzPCCqM130[2lEPTB;MD6wOVIh|ryPNWXBPIdbOjB3NEWzN|Q>
HAECMXLDfZRwfG:6aXOgRZN{[Xl?NXTLVodIOTByIN88US=>M{XNWVI1KGh?NIfBWJNFVVORM1HmemlEPTB;MUOg{txOMVSyNFU1Pzd7Nx?=
CCRF-CEMM{HPXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M1PpdlQ5KGh?NY\SWpF4T0l3ME2wMlAzKM7:TR?=NFPYNFUzODV5MEG0OS=>
NUGC3NV;6cGdVS3m2b4TvfIlkKEG|c3H5Mn\RS2k2OD1yLkKwNkDPxE1?Mln5NlA2Pzl6N{[=
HCT-15NYrDUo97S3m2b4TvfIlkKEG|c3H5NUjRPWVkUUN3ME2wMlA{QCEQvF2=M4X5XlIxPTl2OES4
COLO205NHXUbpZEgXSxdH;4bYMhSXO|YYm=MVm0PEBpM1TSS2ROW09?NWrTfZZrT0l3ME2wMlEh|ryPNXPyVpg6OjB4N{O2Nlc>
Hep3BNVT5cHlXS3m2b4TvfIlkKEG|c3H5MoDJNVEh\A>?NEflbFBKSzVyPUCuNVQh|ryPNU\jc3E6OjB5MUi0O|U>
SKOV3NUC3Z2VqS3m2b4TvfIlkKEG|c3H5M4TKUmlEPTB;MD6wNFEh|ryPMX:yNFcyQTVyNB?=
DWDM{POb2N6fG:2b4jpZ{BCe3OjeR?=M4\xOFQh|ryPMlv2NlQhcA>?MX7HTVUxRTBwMTFOwG0>M3TI[|IxPzN{OEG3
SiHaM2Xoc2N6fG:2b4jpZ{BCe3OjeR?=MmPtOEDPxE1?M4CwbFI1KGh?NILU[4hIUTVyPUCuNVch|ryPMYCyNFc{OjhzNx?=
THP1MmfqR5l1d3SxeHnjJGF{e2G7NHzWb2g4OiCqMYjEUXNQM2PEWGlEPTB;MD6wNFgh|ryPMVeyNFg{OzB3Nx?=
ARPE19NG\BNIhEgXSxdH;4bYMhSXO|YYm=MmjwOFghcA>?M2\VO2ROW09?M2n4XmlEPTB;MD63OkDPxE1?NVzPTGtFOjB7M{G5O|A>
BJM3jrNGN6fG:2b4jpZ{BCe3OjeR?=MUK0PEBpMkHNSG1UVw>?NHTDWm9KSzVyPUKuN|Mh|ryPMkfUNlA6OzF7N{C=
KB8.5MlTGR5l1d3SxeHnjJGF{e2G7M3\3TVUxKM7:TR?=NHrnc2k4OiCqNELJPXJFVVORNFqz[GtKSzVyPUOuN{DPxE1?NU\NTFlyOjFyM{WyN|Q>
H460MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NWfXeJJvPzJiaB?=MX\JR|UxRTBwMECwN|gh|ryPNGLT[FYzOTB4N{mzNC=>
KBNXzlVXRqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MlPUO|IhcA>?MmXWTWM2OD1yLkCwNFI{KM7:TR?=NHvIfmczOTB4N{mzNC=>
MKN45MmPNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M4HoZ|czKGh?Ml7ETWM2OD1yLkCwNFE6KM7:TR?=NEWwemwzOTB4N{mzNC=>
C33AMUjDfZRwfG:6aXOgRZN{[Xl?MkX6NVAxKM7:Zz;tUC=>MWK0PEBpNEfw[JJKSzVyPUCuPFIh|ryPNVHLWXRJOjFyN{GyNlE>
HL60RMXzDfZRwfG:6aXOgRZN{[Xl?Mn76NVAh|ryPNGiyRYc4OiCqNYmyXWQxTE2VTx?=NF\hfGZKSzVyPUCuPVkh|ryPMnHqNlEyPDJzOEC=
MDA231M{i2RWN6fG:2b4jpZ{BCe3OjeR?=M2f4Z|ExKM7:TR?=NX7TdIlsPzJiaB?=MULEUXNQM{H0PGlEPTB;ND63fFExNTVizszNNVT2UZBpOjFzNEKxPFA>
MDA435MV;DfZRwfG:6aXOgRZN{[Xl?M4m1dlExKM7:TR?=NUPHUGFsPzJiaB?=NWLnNZBKTE2VTx?=NYnFdHh7UUN3ME2wMlAxOzVizszNMkTMNlEyPDJzOEC=
CEMNXnY[IM2S3m2b4TvfIlkKEG|c3H5MUG3NkBpNFPWS5NFVVORNUfxSWVnUUN3ME2wMlA3KM7:TR?=NHjpWXQzOTF2NE[yOC=>
Molt4/C8MmryR5l1d3SxeHnjJGF{e2G7MUW3NkBpNWnveJdYTE2VTx?=NV\nW|VDUUN3ME2wMlIh|ryPM3XCUlIyOTR2NkK0
IMR90M4nG[mN6fG:2b4jpZ{BCe3OjeR?=NFvjfoU1QCCqMoDESG1UVw>?NEnLbVdKSzVyPUCuOVkh|ryPM3fkNFIyOjF3NkKz
CCRFMn;sS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M4LlO|k3KGh?NEXJ[mVFVVORNXHteJg4UUN3ME2wMlA{PzVizszNNEjH[pMzOTJ7NkS2Oy=>
HepG2NHjHdpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MWG5OkBpM3fyWmROW09?NFe0NG5KSzVyPUCuNFE6KM7:TR?=MnmzNlEzQTZ2Nke=
HUVECM{jkeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NVr3VY1yQTZiaB?=MnjHSG1UVw>?MoeyTWM2OD1yLkCzNFMh|ryPNIPjW4YzOTJ7NkS2Oy=>
NCI-N87MonNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M3fIZ|k3KGh?M1fUcWROW09?MWXJR|UxRTBwNEG5PEDPxE1?M2T1SlIyOjl4NE[3
HCT8NHjUWnVEgXSxdH;4bYMhSXO|YYm=MVGwMlU5KM7:Zz;tUC=>NFvLT3c3QSCqNYfpTolCTE2VTx?=MWfJR|UxRTBwMEKg{txOMYOyNVM5OTdyNR?=
A375NGHGc2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M{jKO|czKGh?MmTMVGJUMVnJR|UxRTBwMUOg{txOM1XCOlIyPDl4OUey
SF295MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NF\BTZgzPSCwTR?=NFLNdGMzPCCqNX3RVGt4TE2VTx?=M3G5VGlEPTB;ND60JO69VQ>?M{nHXFIyPTV|OEK5
SK-MEL-28MlniS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NH;xcWYzPSCwTR?=M4PxZ|I1KGh?MkPKSG1UVw>?NYXyWWNCUUN3ME2wMlYh|ryPMUKyNVU2Ozh{OR?=
KATOIIIMmLGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NV3WTJZvUUN3ME20MlM5KM7:TR?=M3j6OVIyPTdyN{Ww
P388D1NYXVWI9KT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NGjCNXpKSzVyPUCuN|M5KM7:TR?=NVLiZVFyOjF3N{C3OVA>
H22MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M1ryNFQ5KGh?MnLLTWM2OD1|Nj61NUDPxE1?NX;YbYZVOjF4MkC1Nlk>
S180MkDDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M1KyfFQ5KGh?NHy2SW9KSzVyPUK5MlIh|ryPMXKyNVYzODV{OR?=
SW480NUTmfZg{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MXi0PEBpNHHmZXRKSzVyPUCuNFYh|ryPNHLyc3EzOTZ2MU[5OC=>
HOP62M3PkWGN6fG:2b4jpZ{BCe3OjeR?=NWHCR2FHOjRiaB?=MVrHTVUxRTBwMUSg{txOM3OxRlIyPjd4NUC2
BT549MVzDfZRwfG:6aXOgRZN{[Xl?MnzHNVYxKM7:Zz;tUC=>NEL6SZc2KGR?NUHWUYI{TE2VTx?=NYHqRoFuT0l3ME2wMlAyKM7:TR?=MUSyNVcyOTB3NB?=
Hs578NV7LfFhPS3m2b4TvfIlkKEG|c3H5MWWxOlAh|rypL33MMVW1JIQ>MVPEUXNQM{HBfGdKPTB;MD6wNFYh|ryPM3fTVFIyPzFzMEW0
NCI-H23MWTDfZRwfG:6aXOgRZN{[Xl?M2ThWFE3OCEQvHevcWw>NYPyeYNCPSCmMmnmSG1UVw>?MWfHTVUxRTBwMEC1JO69VQ>?MVKyNVcyOTB3NB?=
PC3NX;6fWxPS3m2b4TvfIlkKEG|c3H5NGjXc3YyPjBizsznM41NMkDOOUBlNEXKZ|RFVVORMUnHTVUxRTBwMEKxJO69VQ>?MWCyNVcyOTB3NB?=
MG63Ml\sS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NEPvV244OiCqMkLETWM2OD1{Lkig{txONWPPelV{OjF5MkG1NVk>
Ew36MXjDfZRwfG:6aXOgRZN{[Xl?MnTlO|IhcA>?NVzpR3RjUUN3ME2wMlAyKM7:TR?=MYWyNVczOTV{OB?=
HEK293M37O[mN6fG:2b4jpZ{BCe3OjeR?=MWi3NkBpNWPldJU3UUN3ME2wMlAyKM7:TR?=NFL4ZnUzOTd{MUWyPC=>
HEK293MW\DfZRwfG:6aXOgRZN{[Xl?NW\zZXFkPzJiaB?=NI[4TlRKSzVyPUCuOFIh|ryPNYTFfIxQOjF5MkG1Nlg>
KB3-1MlLRR5l1d3SxeHnjJGF{e2G7MnvQO|IhcA>?M2HuTmlEPTB;MD6wNkDPxE1?MWqyNVczOTV{OB?=
KBV1NGXNVG1EgXSxdH;4bYMhSXO|YYm=NWG2ZZIyPzJiaB?=NGfQNohKSzVyPUSuO{DPxE1?M{TaO|IyPzJzNUK4
LLC-PK1M1TFUGN6fG:2b4jpZ{BCe3OjeR?=MmTmO|IhcA>?MV\JR|UxRTBwMjFOwG0>MkizNlE4OjF3Mki=
NCI/ADR-RESNWmxbGVuS3m2b4TvfIlkKEG|c3H5NXHYc4VuPzJiaB?=MXzJR|UxRTlwMzFOwG0>MXqyNVczOTV{OB?=
NIH3T3NVXQe5k{S3m2b4TvfIlkKEG|c3H5Mm\uO|IhcA>?MlnlTWM2OD1yLkC1JO69VQ>?M{HwV|IyPzJzNUK4
SW620MUXDfZRwfG:6aXOgRZN{[Xl?NVHL[2tqPzJiaB?=MoTGTWM2OD1yLkCxJO69VQ>?MXOyNVczOTV{OB?=
ZR-75BNX7o[IRIS3m2b4TvfIlkKEG|c3H5M2DWTVczKGh?MYLJR|UxRTBwMESg{txOM17CUFIyPzJzNUK4
ZR-75BMmTSR5l1d3SxeHnjJGF{e2G7M{TS[lczKGh?MXvJR|UxRTJwMEKg{txONVyx[nJkOjF5MkG1Nlg>
GuravNGLxbIhEgXSxdH;4bYMhSXO|YYm=M{\h[VExOCEQvF2=NVfKbVNlPDhiaB?=MlfVSG1UVw>?MX7HTVUxRDBwMTFOwG0>MYqyNVc{PzJ6OB?=
HFFNGLqd2JEgXSxdH;4bYMhSXO|YYm=MmTMO|IhcA>?NWDSc|MyS0N3ME2wMlA{KM7:TR?=NYfzfIVEOjF5NEGxN|E>
BT474NH\X[VBEgXSxdH;4bYMhSXO|YYm=NYPRdlBNPzJiaB?=M4TRSGlEPTB;MD6wO{DPxE1?MVKyNVc1OTh|Mx?=
ChaGoMW\DfZRwfG:6aXOgRZN{[Xl?NVXONJd{PzJiaB?=NFnie|ZKSzVyPUCuPFMh|ryPNWGyeWhHOjF5NEG4N|M>
KATONXrF[IU1S3m2b4TvfIlkKEG|c3H5MVG3NkBpMo\QTWM2OD1yLkOzJO69VQ>?MViyNVc1OTh|Mx?=
NCI-H187NIf4PHVEgXSxdH;4bYMhSXO|YYm=NHHyboU4OiCqMYTJR|UxRTBwMEOg{txOMUKyNVc1OTh|Mx?=
A2780NWLIS4xES3m2b4TvfIlkKEG|c3H5MknpTWM2OD1yLkCwNVIh|ryPM3LONFIyPzd2NEm5
A2780/ADRNWLZUo56S3m2b4TvfIlkKEG|c3H5MXjJR|UxRTBwMUm0JO69VQ>?MWOyNVc4PDR7OR?=
LAMA-84MlLER5l1d3SxeHnjJGF{e2G7NV3FN5R7PDhiaB?=MYTJR|UxRTBwN{Sg{txONXvBeXk4OjF5OUeyPFA>
SH-SY5YNIXvRotEgXSxdH;4bYMhSXO|YYm=NVLHWmhlPDhiaB?=MXvJR|UxRTBwNTFOwG0>MVmyNVc6PzJ6MB?=
Ca9-22NYnX[IVCS3m2b4TvfIlkKEG|c3H5M4fvXFczKGh?MWLEUXNQM2PvbWlEPTB;MD6yOkDPxE1?M3;uUFIyQDByOEW5
K562/A02NF\rOWtEgXSxdH;4bYMhSXO|YYm=M1jsdlQ5KGh?NYjpd5AyTE2VTx?=NXLjO4FFUUN3ME2xO{45PCEQvF2=NHPx[2IzOTh2M{m0NC=>
BT20MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MljKNVAh|ryPM4XNSFczKGh?MnTtRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdIm=MUGyNVg2OjB{Mx?=
AGSMlLwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M2rUZ|Q5KGh?NEDMPXpIUTVyPUCuNFEh|ryPM{DhSlIyQDd3MES2
PC3NVHse2RET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NWDHUZpuPDhiaB?=MYXHTVUxRTBwMEmg{txONFXHfowzOTh5NUC0Oi=>
Neuro2aNHvrclBEgXSxdH;4bYMhSXO|YYm=NHTtWI84OiCqMXPJR|UxRTFwMjFOwG0>MX:yNVk6PjVzOR?=
MCF7NU\DTY1wTnWwY4Tpc44hSXO|YYm=MlvkOVAh|rypL33MMkPKOFghcA>?NHHKVYlFVVORM4npRnJm\HWldHnvckBqdiCYRVfGJI1TVkFiZYjwdoV{e2mxbh?=M33S[VIzODByOUS2
MCF7MVTGeY5kfGmxbjDBd5NigQ>?MWG1NEDPxGdxbVy=NXXHOGk3PDhiaB?=NIDaOmpFVVORNVPOZmhlWmWmdXP0bY9vKGmwIFPZVFE6KG2UTlGg[ZhxemW|c3nvci=>NYjhUYV1OjJyMEC5OFY>
MCF7NYHxNG9jTnWwY4Tpc44hSXO|YYm=NXvrfJk5PTBizsznM41NMn7tOFghcA>?MmPTSG1UVw>?NF;3N2dT\WS3Y4Tpc44hcW5iQWCtNkBo[W2vYTDtVm5CKGW6cILld5Nqd25?M2jGc|IzODByOUS2
HCT8M{ixR2N6fG:2b4jpZ{BCe3OjeR?=NGTwc2w2yqEQvHevcWw>MlOwO|IhcA>?NV7od5hYTE2VTx?=NYr4dFZDUUN3ME2wMlAzKM7:TR?=NIjGNXUzOjByMEm0PS=>
BGC823MoThR5l1d3SxeHnjJGF{e2G7MnHaPVYhcA>?NWPnTJZqTE2VTx?=NViyTpdiUUN3ME2wMlk5KM7:TR?=NELnV3AzOjB5ME[1OC=>
SKOV3M{DoSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MlXHOVAh|ryPMoH6O|IhcA>?NILYe5pFVVORNVfrU3MySW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDTT29XOyClZXzsd{BwfmW{ZYjwdoV{e2mwZzDjMXNz[w>?M2LxfFIzOTF7NEey
RAW264.7NVLQU3l2S3m2b4TvfIlkKEG|c3H5MU[xNEDPxE1?MnvDNlQhcA>?NFH5[IRFVVORNVO0RWVuS3m2b4TvfIlkcXS7IHHzd4V{e2WmIHHzJINmdGxidnnhZoltcXS7MVuyNlEzQTB4MR?=
A375-C5MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NHHCUpQ1QCCqMl;XSG1UVw>?NVHuW2huT0l3ME2wMlA6OTVizszNNF;UfGEzOjF5N{SwPS=>
QGY7701NFHKbZlEgXSxdH;4bYMhSXO|YYm=MUGyOEBpM1HDWGROW09?NVXDNG5MUUN3ME24MlY2KM7:TR?=NX\v[pp7OjJzOEK5NlY>
PC3MNF36[nNEgXSxdH;4bYMhSXO|YYm=NXzNTIx7PzJiaB?=NEDRXpVFVVORM1n3d2lEPTB;MD6yOEDPxE1?NXTjZo9HOjJ{NkSxOFk>
LNcaPMnj6RZBweHSxc3nzJGF{e2G7M3;3eVIxyqEQvHevcWw>NITHNm8zPCCqNGXheY54[XSnch?=M1jDRmlv\HWldHnvckBw\iCjcH;weI9{cXNiYYPz[ZN{\WRiYYOgbY5kemWjc3WgbY4h[2G|cHHz[UA{NzdiYXP0bZZifGmxbh?=MoXtNlIzPjR5NUi=
SKOV3MnO4SpVv[3Srb36gRZN{[Xl?M{XFSlUh|ryPMVKxJIg>NF[0WVNFVVORMlXQSJJ2\yC3cIThb4UhcW5iZH;4c5J2[mmlaX6tdoV{cXO2YX70JIh2dWGwIGPLU3Y{KGOnbHygcpVkdGW3M{PNZlIzOjd4OUm4
SKOV3M1;3bWZ2dmO2aX;uJGF{e2G7MYi1JO69VQ>?NIHxVWEyKGh?NEHTeIZFVVORNGXHXFhE\WyudXzhdkB2eHSja3WgbY4h\G:6b4L1ZolkcW5vcnXzbZN1[W62IHj1cYFvKFONT2[zJINmdGy|M3LEXVIzOjd4OUm4
B16NIXTR3VEgXSxdH;4bYMhSXO|YYm=M{LBSVczKGh?NWLPe5MyTE2VTx?=NV\OZVNlUUN3ME2wMlEh|ryPNXzpWVVUOjJ|M{C2N|Q>
SiHaNGDEUGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M{n2fGdKPTB;MD6xOEDPxE1?NEHhPFgzOjN4MU[4OC=>
SK-N-SHNUWxdWJNS3m2b4TvfIlkKEG|c3H5NF\5[W81QCCqNIPPWHdKSzVyPUCuPVch|ryPMYKyNlM5PjV{OB?=
HuH7NYPUUZdZTnWwY4Tpc44hSXO|YYm=M3T2NVI2KG6pL33MNF7iOo84OiCqNVLmRWI{TE2VTx?=MlW2TY5lfWO2aX;uJI9nKHOnbnXzZ4Vv[2ViYYPz[ZN{\WRiYYOgbY5kemWjc3WgbY4he2WwZYPj[Y5k\SCjc4PvZ4lifGWmIHLleIEu\2GuYXP0c5Nq\GG|ZTDhZ5Rqfmm2eR?=M336WVIzPDB7N{ex
HuH7Mm\XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NHT0Z2wzPSCwZz;tUC=>NVzDWZlpPzJiaB?=Ml\ISG1UVw>?NXrWWlVWSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBDemSXIHnuZ49zeG:{YYTpc44>M3vGVVIzPDB7N{ex
K562/A02MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MmjpO|IhcA>?MlX1SG1UVw>?M1fvRWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgcZVtfGmmcoXnMZJme2m|dHHueEBpfW2jbjDLOVYzN0FyMjDj[YxteyCxdnXy[ZhxemW|c3nu[{BxNWeueXPvdJJwfGWrbjD3bZRpKEmFNUCgc4YhPDZwNkmg{txOMUSyNlQ2ODF|NB?=
SK-MEL-2M1ri[2N6fG:2b4jpZ{BCe3OjeR?=MYG0PEBpM3;DSWlEPTB;MD6wNFIh|ryPNUfHPY0yOjJ2OEOzPVU>
XF498NYLKWo83S3m2b4TvfIlkKEG|c3H5MYm0PEBpNGiySodKSzVyPUCuNFE2KM7:TR?=NYPRfXBnOjJ2OEOzPVU>
LLCNFu2[2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=Ml3oOFghcA>?NYnOXIQ6UUN3ME2wMlIxPyEQvF2=M3\jWlIzPTF3M{[2
NCI-H290NUfFXJN1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M2TTTlIh|ryPM2HIZlQ5KGh?NXXLdWluUUN3ME2wMlMzKM7:TR?=MWWyNlUyPTN4Nh?=
U87MGNYPVSWN5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MY[yJO69VQ>?NVizfmxvPDhiaB?=Mn;ETWM2OD1yLke5JO69VQ>?MnzNNlI2OTV|Nk[=
KB/VCRMlnQR5l1d3SxeHnjJGF{e2G7M{PVO|UxOCEQvF2=M3PwNFQ5KGh?NHrOW2VFVVORNX3EfZdiUUN3ME2wMlQ2KM7:TR?=NYfjcnR1OjJ3M{ezOlI>
SMMC7721M332fWN6fG:2b4jpZ{BCe3OjeR?=MV21NFAh|ryPM{nkWVQ5KGh?MkfKSG1UVw>?NXvoV4VEUUN3ME2wMlM4KM7:TR?=MkPPNlI2Ozd|NkK=
786-0Moj4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MmnLNlUh|rypL33MMVe0PEBpNWW2UVl3UUN3ME2yMlEh|ryPMYSyNlU{PzZ6MB?=
NCI/ADRM{O5cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MXGyOUDPxGdxbVy=NXezZYVRPDhiaB?=MmG1TWM2OD1zMz61JO69VQ>?MkLLNlI2Ozd4OEC=
SW620MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NIHRV3oyODBizszNMkXGO|IhcA>?MkfpSG1UVw>?MU\JR|UxRTBwMESg{txONEHXbFUzOjV3NUG1Ni=>
WI38MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NXexRpdIOTByIN88US=>NHvFVmk4OiCqNHno[GFFVVORNGDLUXZKSzVyPUCuNFQh|ryPNGW5W2QzOjV3NUG1Ni=>
J774A.1M3rkbWN6fG:2b4jpZ{BCe3OjeR?=NVfqPIRFPzJiaB?=NXjSWHRYTE2VTx?=M1uwdGlEPTB;MD6wNkDPxE1?NVjYRYFSOjJ4MEi2O|U>
BMDMNV;hRlEyS3m2b4TvfIlkKEG|c3H5NEnMZnozPTBizsznM41NMVW3NkBpMXrJR|UxRTRwNjFOwG0>NXj6cWtXOjJ4MU[1OVQ>
HMEC1NW\MSoExS3m2b4TvfIlkKEG|c3H5M4nFVlI2OCEQvHevcWw>NGH6TFc4OiCqNF\4UllKSzVyPUCuNFYh|ryPMYqyNlYyPjV3NB?=
MKN45NYi0NIRTS3m2b4TvfIlkKEG|c3H5NVLQTZlDPDhiaB?=MmfOSG1UVw>?NGDyVFBKSzVyPUCuNVY5KM7:TR?=NWPIR3k4OjJ4NEe3NlM>
B16NF\lNIc1QCCqNHzMemVKSzVyPUCuNFMh|ryPM13iUVIzPjZ6NEWx
U2OSNFXvVpdEgXSxdH;4bYMhSXO|YYm=NGTTblM1KM7:TR?=MmCyO|IhcA>?MXHEUXNQMkfDTWM2OD1|LkSg{txOMX2yNlc1QTJ5OR?=
HCT15MkPZR5l1d3SxeHnjJGF{e2G7MnywOFghcA>?NEDQdmFFVVORM2jqZmlEPTB;MD6wNFUh|ryPMX6yNlg2QDJ7OB?=
SKLU1NEnC[5VEgXSxdH;4bYMhSXO|YYm=NUW0XHdYPDhiaB?=MnjDSG1UVw>?MXfJR|UxRTBwMEC2O{DPxE1?NET2ZmYzOjh3OEK5PC=>
MESSA/DX5NF\MW3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MojjNVAxKM7:Zz;tUC=>M1GyXVczKGh?M2jDXGROW09?MU\JR|UxRTBwMkWg{txONFzpZ24zOjl2NEGyNS=>
A549NIC3RllEgXSxdH;4bYMhSXO|YYm=M322dWlEPTB;MD6wNFEh|ryPM3y0OlIzQTVzMESw
HL60/AMWXDfZRwfG:6aXOgRZN{[Xl?NVLqdXVvOThiaB?=NIrLR3lKSzVyPU[uO{DPxE1?MYOyNlk5PTB{Nx?=
MG63MXvDfZRwfG:6aXOgRZN{[Xl?MmXWTWM2OD1{Lkeg{txOM1zB[VI{ODR|NEm4
BALB/3T3MX;DfZRwfG:6aXOgRZN{[Xl?NXq2fVR7OTByIN88[{9uVA>?NFvEb|I4OiCqNVnTZndtTE2VTx?=MXXJR|UxRTFwOUGg{txOM1PtSFI{ODd7NUKz
HL60/VincNYHUPVNyS3m2b4TvfIlkKEG|c3H5MV:xNFAh|rypL33MM2fiV|czKGh?NX7JfJdpTE2VTx?=NVKwdnE5S3m2b4TvfIlkcXS7IHHnZYlve3RidnnuZ5Jqe3SrbnWtdoV{cXO2YX70JIh2dWGwIFjMOlAwXmmwYzDj[YxteyC5aYToJGlEPTBib3[gNE46OSEQvF2=NGLnU|AzOzB5OUWyNy=>
Bcap37MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NIfTS2EzOCEQvF2=MXy3NkBpMUXEUXNQMVzJR|UxRTFwMkig{txOMX[yN|EzPDJzMB?=
MGC803NXnQU2U4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NFKzU5MzOCEQvF2=M3TwV|czKGh?MV\EUXNQNGPY[2pKSzVyPUCuO{DPxE1?NHLoOVczOzF{NEKxNC=>
MOLT4MkDKR5l1d3SxeHnjJGF{e2G7MlXXOFghcA>?NFuzOYNFVVORNEHINYtKSzVyPUCuNFIh|ryPMYOyN|IyQDdzOB?=
WHCO1NUfnTWxzS3m2b4TvfIlkKEG|c3H5M4q2UFQ5KGh?MVLEUXNQMVHJR|UxRTBwNTFOwG0>NFHMVVczOzN3M{e0Oy=>
AT6-1MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MUG3NkBpNFLh[HFKSzVyPUKg{txOM1TkVVI{OzZyNUKx
L929NFe0PW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MXe3NkBpMmPtTWM2OD1yLkG2NUDPxE1?MVWyN|M3ODV{MR?=
OSRGANHPqT4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MkjsO|IhcA>?MWnJR|UxRTBwMEmzJO69VQ>?MmnhNlM{PjB3MkG=
POS1MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MmXEO|IhcA>?M3\vTGlEPTB;MD6wOFMh|ryPMofiNlM{PjB3MkG=
HeLaMWjDfZRwfG:6aXOgRZN{[Xl?NVHZdIx[OSEQvF2=MnPCO|IhcA>?MYjJR|UxRTBwMEGg{txOM3HtSVI{PDdyMUO5
SK-MELM2\He2N6fG:2b4jpZ{BCe3OjeR?=NIDPSG01QCCqMmr6SG1UVw>?Ml7hTWM2OD1zLkWg{txOMUKyN|U1Pzh2Mx?=
MA9.3NYjXRpBsS3m2b4TvfIlkKEG|c3H5NH6wd4wyODBizszNMkXZOFghcA>?NYfQcYxsUUN3ME2wMlA5PiEQvF2=Ml\INlM2Pzh4OUC=
A673MWfDfZRwfG:6aXOgRZN{[Xl?M{P3OlczKGh?NIq4WIdEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPjd|IHPlcIx{KGGodHXyJFczKGi{czDifUBz\XOjeoXybY4wemW|b4L1[olvNWKjc3XkJIZtfW:{ZYPj[Y5k\SCjc4PhfUB4cXSqIFnDOVAhd2ZiMD6xO{DPxE1?NUDscVhEOjN4MEC5NlU>
A673NWHsepJDSXCxcITvd4l{KEG|c3H5NEPzdFUzPCCqMXjEUXNQNFjkTmtKdmS3Y4Tpc44hd2ZiYYDvdJRwe2m|IHHzd4V{e2WmIHHzJINie3Cjc3WtN{Bi[3SrdnH0bY9vKHerdHigSWM2OCCxZjCwMlM6KM7:TR?=MWeyN|YxODl{NR?=
MDA-MB-436MYHDfZRwfG:6aXOgRZN{[Xl?Mo\CO|IhcA>?M{m3O2lEPTB;MD6xJO69VQ>?NFTkOWkzOzZyMEmyOS=>
MNNG-HOSM4Ps[GN6fG:2b4jpZ{BCe3OjeR?=MkWzO|IhcA>?M2PPUWlEPTB;MD61PUDPxE1?NVfEOo1XOjN4MEC5NlU>
NCI-H929MV3DfZRwfG:6aXOgRZN{[Xl?Mm[3O|IhcA>?NHPOZlVKSzVyPUCuNFY2KM7:TR?=MYWyN|YxODl{NR?=
SK-BR-3MXfDfZRwfG:6aXOgRZN{[Xl?Ml\MO|IhcA>?MofHTWM2OD1yLkC5JO69VQ>?MWqyN|YxODl{NR?=
SK-ES-1NYKzbYF2S3m2b4TvfIlkKEG|c3H5M1;4[|czKGh?MkjETWM2OD1yLkC0NkDPxE1?Mm\CNlM3ODB7MkW=
SK-UT-1M3XYcmN6fG:2b4jpZ{BCe3OjeR?=MXq3NkBpMlPBTWM2OD1yLkC3OkDPxE1?MoTQNlM3ODB7MkW=
SW872M1qzNGN6fG:2b4jpZ{BCe3OjeR?=MXy3NkBpNYPMUYY4UUN3ME2wMlE1KM7:TR?=NGf6dZIzOzZyMEmyOS=>
U266NF6yZpREgXSxdH;4bYMhSXO|YYm=MUS3NkBpMUPJR|UxRTBwNkeg{txOMUCyN|YxODl{NR?=
JURKAT-TALLMlHDR5l1d3SxeHnjJGF{e2G7Mnj2OFghcA>?Ml7BTWM2OD1yLkCwPVYh|ryPMmnCNlM3PzN{MUi=
B16F10NX7kR4k{S3m2b4TvfIlkKEG|c3H5MonMOFghcA>?MoHzSG1UVw>?MUDJR|UxRTBwMEeyJO69VQ>?MoPiNlM4Pzd6OUi=
C643MkLhR5l1d3SxeHnjJGF{e2G7NHPINm4zPSCvTR?=M{XET|I1KGh?NFHhbXpKSzVyPUCuNFch|ryPNG\LRXgzOzhyMkexOi=>
HGFM2\VVWN6fG:2b4jpZ{BCe3OjeR?=M134V|I2KG2PMXiyOEBpMoDlTWM2OD1yLkWg{txOM2TN[FI{QDB{N{G2
786NXXtdm5lS3m2b4TvfIlkKEG|c3H5MUS0PEBpNVyzPJhFTE2VTx?=MkG1TWM2OD1yLkOzJO69VQ>?MofyNlM5OTB{OEK=
LS180NV23dGtYS3m2b4TvfIlkKEG|c3H5M2PWXFczKGh?MnXiSG1UVw>?M3XnW2lEPTB;MD6wOEDPxE1?Mo\RNlM5OjdzN{m=
COLO205MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M2Lr[lExOCEQvF2=M{nPO|Q5KGh?NGLqU2VIUTVyPUCuNVQh|ryPMYeyN|g1QTJyNx?=
DWDM2LzU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MVqxNFAh|ryPNHvs[II1QCCqMVLHTVUxRTBwMTFOwG0>NIG2W3czOzh2OUKwOy=>
GuravMmnUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NH;KUFYyODBizszNM1LpPFQ5KGh?NH\0XWtIUTVyPUCuNVch|ryPMV[yN|g1QTJyNx?=
HOP62NHuzNpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MUOxNFAh|ryPNGDYVnI1QCCqNUjtOYM{T0l3ME2wMlE1KM7:TR?=NE\sVlEzOzh2OUKwOy=>
786-0M2Ha[2N6fG:2b4jpZ{BCe3OjeR?=NILqSogyODBizszNNUm1TFhiPDhiaB?=MkjxS2k2OD1yLkGzJO69VQ>?Ml\YNlM5PzF7MEW=
ACHNNUHWfnY4S3m2b4TvfIlkKEG|c3H5M1zzelExOCEQvF2=MWO0PEBpNUnZZ2xmT0l3ME2wMlA5KM7:TR?=MnfTNlM5PzF7MEW=
Caki1NYHGVVc4S3m2b4TvfIlkKEG|c3H5NEjMeYQyODBizszNNVPxc5I2PDhiaB?=MoLqS2k2OD1yLkm1JO69VQ>?MUGyN|g4OTlyNR?=
EKVXMlL3R5l1d3SxeHnjJGF{e2G7Ml;kNVAxKM7:TR?=MonPOFghcA>?NYnLS3BTT0l3ME2wMlQyKM7:TR?=MV:yN|g4OTlyNR?=
HCC2998M{Gy[GN6fG:2b4jpZ{BCe3OjeR?=NHHwZVAyODBizszNM3XsfFQ5KGh?M2\ieGdKPTB;MD6yOkDPxE1?MmW1NlM5PzF7MEW=
HOP92MoqzR5l1d3SxeHnjJGF{e2G7MoXkNVAxKM7:TR?=MVi0PEBpMVTHTVUxRTBwMTFOwG0>M2n0b|I{QDdzOUC1
IGROVINF3HPXFEgXSxdH;4bYMhSXO|YYm=NYDvenU2OTByIN88US=>NY\ZTHRVPDhiaB?=M{HyR2dKPTB;MD6xO{DPxE1?M3PqO|I{QDdzOUC1
KM12NUHyVnV[S3m2b4TvfIlkKEG|c3H5MW[xNFAh|ryPMl3ROFghcA>?Mon1S2k2OD1yLkK3JO69VQ>?MWSyN|g4OTlyNR?=
LOXIMVINWXiXGFUS3m2b4TvfIlkKEG|c3H5M2nqUFExOCEQvF2=Mlz1OFghcA>?NX3Pc2E3T0l3ME2wMlA4KM7:TR?=MXmyN|g4OTlyNR?=
M14M{HQ[WN6fG:2b4jpZ{BCe3OjeR?=NUH4VItCOTByIN88US=>NUexcXNuPDhiaB?=MkH4S2k2OD1yLkG4JO69VQ>?NH[3SHMzOzh5MUmwOS=>
MALME-3MNXXwNpBIS3m2b4TvfIlkKEG|c3H5MmjXNVAxKM7:TR?=M{PNdVQ5KGh?MlrRS2k2OD1yLkGyJO69VQ>?MmXJNlM5PzF7MEW=
NCI-H226MUPDfZRwfG:6aXOgRZN{[Xl?M2jrbFExOCEQvF2=MYW0PEBpMY\HTVUxRTBwMEWg{txOM4LSfFI{QDdzOUC1
NCI-H322MNEjQVllEgXSxdH;4bYMhSXO|YYm=NF\sVmEyODBizszNNIrCWXg1QCCqM1;hemdKPTB;MD61OEDPxE1?MoHzNlM5PzF7MEW=
NCI-H522MYjDfZRwfG:6aXOgRZN{[Xl?NF7YRY8yODBizszNNHX0VYI1QCCqNHXqUnlIUTVyPUCuNFMh|ryPMnXxNlM5PzF7MEW=
OVCAR4MV\DfZRwfG:6aXOgRZN{[Xl?M3KxT|ExOCEQvF2=MlTYOFghcA>?MlLvS2k2OD1yLkO3JO69VQ>?MUCyN|g4OTlyNR?=
OVCAR5MYTDfZRwfG:6aXOgRZN{[Xl?M3frW|ExOCEQvF2=NI\NRos1QCCqNVTOTZBZT0l3ME2wMlQyKM7:TR?=NH7oeZgzOzh5MUmwOS=>
OVCAR-8MX3DfZRwfG:6aXOgRZN{[Xl?Mo[0NVAxKM7:TR?=M4exelQ5KGh?MVfHTVUxRTBwMTFOwG0>MoS2NlM5PzF7MEW=
PRMI8226MkDPR5l1d3SxeHnjJGF{e2G7Mn\MNVAxKM7:TR?=MkTnOFghcA>?MYrHTVUxRTBwMEig{txONVrmUpRFOjN6N{G5NFU>
RXF393MVLDfZRwfG:6aXOgRZN{[Xl?MnnqNVAxKM7:TR?=Mmf5OFghcA>?MVfHTVUxRTBwMTFOwG0>MnK3NlM5PzF7MEW=
SF539NULFVG11S3m2b4TvfIlkKEG|c3H5NEn4R3QyODBizszNNVjud3Z7PDhiaB?=MmPFS2k2OD1yLkGyJO69VQ>?MUmyN|g4OTlyNR?=
SK-MEL-28NYfNbpZSS3m2b4TvfIlkKEG|c3H5MXSxNFAh|ryPMnK4OFghcA>?MVTHTVUxRTBwMkGg{txOMmq1NlM5PzF7MEW=
SN12CMlPVR5l1d3SxeHnjJGF{e2G7MWGxNFAh|ryPNHXBboI1QCCqM2rk[GdKPTB;MD6wO{DPxE1?MkPZNlM5PzF7MEW=
SNB19M3:4WmN6fG:2b4jpZ{BCe3OjeR?=M4jTfVExOCEQvF2=NIX0bnQ1QCCqNGrRd3ZIUTVyPUCuNFQh|ryPNYLCR486OjN6N{G5NFU>
SNB75NUD1XHJxS3m2b4TvfIlkKEG|c3H5M2HkdVExOCEQvF2=NU[xfIhvPDhiaB?=MnGyS2k2OD1yLkC3JO69VQ>?Mm\jNlM5PzF7MEW=
SRMVXDfZRwfG:6aXOgRZN{[Xl?NVHhcVlYOTByIN88US=>NEW1UXU1QCCqMV;HTVUxRTBwMEOg{txOMmjUNlM5PzF7MEW=
TK10M1PCd2N6fG:2b4jpZ{BCe3OjeR?=NYjHUJNSOTByIN88US=>NXfVXIxnPDhiaB?=Mkj3S2k2OD1yLkG4JO69VQ>?NVvobldKOjN6N{G5NFU>
U251NV\Be4JyS3m2b4TvfIlkKEG|c3H5NVPiWYp4OTByIN88US=>NY\FbFBlPDhiaB?=MWnHTVUxRTBwMESg{txOM2TzV|I{QDdzOUC1
UACC257MnPpR5l1d3SxeHnjJGF{e2G7NVjITYFzOTByIN88US=>MljnOFghcA>?NXXyXpF{T0l3ME2wMlE1KM7:TR?=M{TYSlI{QDdzOUC1
UO31MkLtR5l1d3SxeHnjJGF{e2G7MWOxNFAh|ryPM2qwSlQ5KGh?MkDmS2k2OD1yLkS5JO69VQ>?M1PNOFI{QDdzOUC1
HaCaTM{nSSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7Mke5NlUh|rypL33MNEC1eoU1QCCqNHnWXXJVT0l3ME2wMlQh|ryPNX\1ZY9pOjN6N{[zN|g>
H9c2NVzqU3VqTnWwY4Tpc44hSXO|YYm=NVHqNms2PSEQvF2=NXjzbWJmOjRiaB?=MWHBcpRqd3irZHHueEBi[3Srdnn0fUBie3Onc4Pl[EBieyCrboTyZY1qfG:laH;u[JJq[WxiUl;TJIxmfmWuNFvrUXYzOzl5M{KxNy=>
H9c2NUOzVnFpTnWwY4Tpc44hSXO|YYm=M4XQNFUh|ryPMnKwNlQhcA>?MXzBcpRqd3irZHHueEBi[3Srdnn0fUBie3Onc4Pl[EBieyCrboTyZYNmdGy3bHHyJI1idG:weXzkbYFt\GWqeXTlJIxmfmWuNInFNYUzOzl5M{KxNy=>
H9c2NIDjPHdHfW6ldHnvckBCe3OjeR?=NYraW3JpPSEQvF2=M1\NOVI1KGh?MUfBcpRqd3irZHHueEBi[3Srdnn0fUBie3Onc4Pl[EBieyCrboTyZYNmdGy3bHHyJHJQWyCuZY\lcC=>NX3OXWF2OjN7N{OyNVM>
H9c2NEjDUGJHfW6ldHnvckBCe3OjeR?=NY\wNnpbPSEQvF2=NF;qflQzPCCqM2HYSmNmdGy3bHHyJJVxfGGtZR?=MkT1NlM6PzN{MUO=
MCF7NI[5NlVHfW6ldHnvckBCe3OjeR?=MXu1JO69VQ>?MYmyOEBpNFjZe5hCdnSrb4jp[IFvfCCjY4Tpeol1gSCjc4Pld5Nm\CCjczDpcpRz[W2rdH;jbI9v\HKrYXygVm9UKGyndnXsMXKyN|k4OzJzMx?=
MCF7NYSz[3IzTnWwY4Tpc44hSXO|YYm=M2jGV|Uh|ryPMlXhNlQhcA>?MVTD[YxtfWyjcjD1dJRic2V?NUDybol2OjN7N{OyNVM>
MCF7Ml;6SpVv[3Srb36gRZN{[Xl?NEXCbJg2KM7:TR?=MkDvNlQhcA>?NFXDSWpCdnSrb4jp[IFvfCCjY4Tpeol1gSCjc4Pld5Nm\CCjczDpcpRz[WOnbHz1cIFzKG2jbH;ufYxlcWGuZHXofYRmKGyndnXsMo\HNlM6PzN{MUO=
MCF7NGGzeI1HfW6ldHnvckBCe3OjeR?=MnnCOUDPxE1?NUjlSFdjOjRiaB?=NVPmNIlwS2WubIXsZZIhfXC2YXvlM1\6SVI{QTd|MkGz
MDA-MB-231NVvYVpp3TnWwY4Tpc44hSXO|YYm=MnLOOUDPxE1?MoLaNlQhcA>?M4HOdmNmdGy3bHHyJJVxfGGtZR?=MoCwNlM6PzN{MUO=
MDA-MB-231NHHWSJlHfW6ldHnvckBCe3OjeR?=NGjBPJA2KM7:TR?=MlGwNlQhcA>?NYW5V4JVSW62aX;4bYRidnRiYXP0bZZqfHliYYPz[ZN{\WRiYYOgbY51emGlZXzseYxieiCvYXzvcplt\GmjbHTlbJll\SCuZY\lcC=>NULjSHlYOjN7N{OyNVM>
MDA-MB-231MnrVSpVv[3Srb36gRZN{[Xl?M17I[FUh|ryPM1z3[VI1KGh?M3TTN2FvfGmxeHnkZY51KGGldHn2bZR6KGG|c3Xzd4VlKGG|IHnueJJidWm2b3Poc45lemmjbDDSU3MhdGW4ZXy=NVPUWVB7OjN7N{OyNVM>
KB/HeLaNUHl[49jS3m2b4TvfIlkKEG|c3H5MXq0OUBpMYnFR|UxRTBwMkWg{txOMWeyN|k5QDN3MR?=
HUVECM{i0TGN6fG:2b4jpZ{BCe3OjeR?=MWm0PEBpM4XqNmlEPTB;MD6wPFA4KM7:TR?=NX7lbZZVOjRyMUKzO|g>
HepG2MmTxSpVv[3Srb36gRZN{[Xl?M{HyN|QxKM7:Zz;tUC=>MojSOFghcA>?NGXiNpJFVVORNGexVWhKdmirYnn0bY9vKG:oIGTST{B4cXSqIFnDOVAhd2ZiMD6wNFI2KM7:TR?=M13kXFI1ODF|NEGx
MRC5NH\PT5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M2\oZVczKGh?NX3TNY9uUUN3ME2wMlEh|ryPNW\zdm9TOjRyMkG0OlI>
HUVECNHXLWWlHfW6ldHnvckBCe3OjeR?=M{W3[lUh|ryPNEW1coozKGh?MWTD[YxtfWyjcjD1dJRic2V?NV7u[|lEOjRyMki0OFY>
MDA-MB-435MUHDfZRwfG:6aXOgRZN{[Xl?NW[5TVdyOTByIN88US=>MkfpOFghcA>?MkXxTWM2OD1yLkG1JO69VQ>?Mn24NlQxOjh2NE[=
AS49-RAWNIS5V4tEgXSxdH;4bYMhSXO|YYm=MmPuNVAxKM7:TR?=M4j4b|Q5KGh?MWPJR|UxRTN{Lke4JO69VQ>?M2DQSVI1ODd5NUK4
Caov3MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M3:1S|czKGh?MVnJR|UxRTBwMTFOwG0>MV[yOFA6PTB6OR?=
LNcaPNV3vZlJnTnWwY4Tpc44hSXO|YYm=NUWyZmlLOyEQvF2=MnXWNlQhcA>?MnrNTY5kemWjc3Wgc4Yh[2ynYY\l[EBk[XOyYYPlMVkhdGW4ZXy=NITBR20zPDB7NUC4PS=>
LNcaPNYPFPHZsTnWwY4Tpc44hSXO|YYm=M2\4PVMh|ryPNXriTG9POjRiaB?=MV;VdE1z\We3bHH0bY9vKG:oIIC1N{BmgHC{ZYPzbY9vMoTZNlQxQTVyOEm=
OVCAR8M3\1Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NX\MXWI3OjBizszNMmfFO|IhcA>?Mn3ORY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdIm=MmGyNlQxQTVyOEm=
U2OSNWTuOWd2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NF\iNWw4OiCqMlHpTWM2OD1yLkOg{txONFnlRZEzPDB7NUC4PS=>
Caco2NHLITplEgXSxdH;4bYMhSXO|YYm=M372e|QxKM7:TR?=NVnoXXNZOjRiaB?=M{PN[WN6fG:2b4jpZ4l1gQ>?M3;aZ|I1ODl7OUm0
MDA-MB-468MojHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NHfpdJUyOCEQvF2=M{LKe|czKGh?MoDLS2k2OD1yLkC4OUDPxE1?NFX4ZmUzPDF4M{eyPS=>
Caco2MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MlfOOFghcA>?MXHHTVUxRTBwM{Kg{txOMlrUNlQyQDRyN{[=
MKN28MlTHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NHzFbI81QCCqNECxU3hIUTVyPUCuNlQh|ryPMUmyOFE5PDB5Nh?=
SGC7901MUnDfZRwfG:6aXOgRZN{[Xl?NUnqe2lzUUN3ME2wMlAyOSEQvF2=MUSyOFE6PTR4Nh?=
Bel7402M1;he2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NHjGTFg6PiCqNHG1XYhFVVORM{TrNWlEPTB;MD61O|gzKM7:TR?=NEnXZYEzPDJzMU[zPS=>
CHP100Mlj4R5l1d3SxeHnjJGF{e2G7MnzWO|IhcA>?M2K2UWlEPTB;MD63PUDPxE1?MoDqNlQzPTF2MUe=
MGC803M3XzTWN6fG:2b4jpZ{BCe3OjeR?=Mm\rO|IhcA>?MXvJR|UxRTBwMUeg{txOM2X1XVI1OzdyMUG0
ME180MmjYR5l1d3SxeHnjJGF{e2G7MlnEOFghcA>?MXvJR|UxRTBwM{mg{txOMlTDNlQ1QDdzOEi=
L929NH\lTVlEgXSxdH;4bYMhSXO|YYm=NIDaT5gyNjFyIN88US=>NUTXXG9WPzJiaB?=NWfhWYM2TE2VTx?=M{f5c2lEPTB;MD6xOkDPxE1?NHXIbJgzPDV|MECzNC=>
MX1M17mR2N6fG:2b4jpZ{BCe3OjeR?=NYjrXmVLOS5zMDFOwG0>MUG3NkBpNH3tcFFFVVORMXfJR|UxRTBwNTFOwG0>NFjYO2szPDV|MECzNC=>
V79MXvDfZRwfG:6aXOgRZN{[Xl?MX6xMlExKM7:TR?=MofJO|IhcA>?NXu4OmZtTE2VTx?=MWTJR|UxRTBwMkSg{txOMor4NlQ2OzByM{C=
CCRF-CEMNGHIUGZEgXSxdH;4bYMhSXO|YYm=M1jUdGROW09?M1;JPGlEPTB;MD6wNFkh|ryPM3j1O|I1PTZzNkew
CEM/ADR5000M3LlU2N6fG:2b4jpZ{BCe3OjeR?=MkfKSG1UVw>?NV7ucYtqS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hdXWudHnkdpVoNXKnc3nzeIFvfCCFRV2vRWRTPTByMDDj[YxteyCneIDy[ZN{cW6pIICt[4x6[2:ycn;0[YlvKHerdHigTWM2OCCxZjCyN{4zPyEQvF2=NWLPPYZIOjR3NkG2O|A>
26-L5MmPnSpVv[3Srb36gRZN{[Xl?MoW4OkBpNYniTVR2SW62aXnueoF{cX[nIHHjeIl3cXS7MmnGNlQ2QTJ7OUO=
BALB/3T3MnnqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NHTxW|ZKSzVyPUCuOUDPxE1?M4j3PVI1PjNzMUmw
16HBEMV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NYrwc3JGOTBizszNNWi1bGozPzJiaB?=NIHPdoNFVVORMlfCS2k2OD1yLkG4JO69VQ>?M3TFe|I1PjVyNkSz
HLFNF21THJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NGHjZY4yOCEQvF2=M4nZUlczKGh?NIDTUGlFVVORMlzRS2k2OD1yLkOzJO69VQ>?NIi5OpIzPDZ6NkCxNS=>
SGC7901M2TRUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MlT3NVAh|ryPNYj0OXNCPzJiaB?=MkjNSG1UVw>?M1jRXmdKPTB;MD61OUDPxE1?MX:yOFY5PjBzMR?=
A431MWLDfZRwfG:6aXOgRZN{[Xl?NGnKSVhKSzVyPUCuNFAyOzVizszNM2O4UlI1QDlyNkWy
HT-29NEPDbHpHfW6ldHnvckBCe3OjeR?=NXmzT4k5OjVizszNMUiyOEBpMkHsTY5pcWKrdHnvckBw\iCPUmCzMY1m\GmjdHXkJIRzfWdicnXzbZN1[W6lZTDpckBld3ixcoXibYNqdi2{ZYPpd5RidnRiaIXtZY4hUFRvMkmgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5kemWjc3WgbY4h\HK3ZzDhZ4N2dXWuYYTpc44>NEHKR5IzPDlyMEOzOy=>
HT-29M2XBdGZ2dmO2aX;uJGF{e2G7MV[1JO69VQ>?M2fHRVI1KGh?NYX3OlA5UW6qaXLpeIlwdiCxZjDNVnA{KGmwIHTvfI9zfWKrY3nuMZJme2m|dHHueEBpfW2jbjDIWE0zQSClZXzsd{Bie3Onc4Pl[EBieyCwaYTyZZRqd25ib3[geJlzd3OrbnWgdoV{cWS3ZYO=Mn3kNlQ6ODB|M{e=
HT-29NILjfZJHfW6ldHnvckBCe3OjeR?=NUDVW5U4PSEQvF2=NUPOXFRqOSCqMlP3TY5pcWKrdHnvckBw\iCPUmCzMY1m\GmjdHXkJIRzfWdicnXzbZN1[W6lZTDpckBld3ixcoXibYNqdi2{ZYPpd5RidnRiaIXtZY4hUFRvMkmgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5kemWjc3WgbY4h\HK3ZzDhZ4N2dXWuYYTpc44>MX2yOFkxODN|Nx?=
HT-29NFLOOGtHfW6ldHnvckBCe3OjeR?=MX61JO69VQ>?MnftNUBpNH\BUJFKdmS3Y4Tpc44hd2Zibnn0dol1\SCycn;keYN1cW:wIHnuJIRwgG:{dXLpZ4lvNXKnc3nzeIFvfCCqdX3hckBJXC1{OTDj[Yxtew>?M1\rbFI1QTByM{O3
NARMmrDSpVv[3Srb36gRZN{[Xl?M3fDNVUh|ryPMVmyJIg>NVnnVWdGTHK3ZzD1dJRic2ViaX6g[I95d3K3YnnjbY4uemW|aYP0ZY51KGi3bXHuJG5CWiClZXzsJJBt[XOvYTDt[Y1jemGwZR?=MV2yOFkxODN2NB?=
NARM3;iXmN6fG:2b4jpZ{BCe3OjeR?=NXHuRWxzOTBizszNNWLUTVNxOjRiaB?=NVHa[osxS3m2b4TvfIlkcXS7IHHzd4V{e2WmIHHzJIlv\HWldHnvckBw\iClZXzsJIRm[XSqMkHhNlQ6ODB|NES=
NARMoOyR5l1d3SxeHnjJGF{e2G7Mln3NVAxKM7:TR?=M1HnTlI1KGh?M3T0OWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGSxeH;yeYJq[2mwLYLld4l{fGGwdDDoeY1idiCQQWKgZ4VtdHNiYYPz[ZN{\WRiYYOgZ4VtdCC4aXHibYxqfHl?NUi0bGxNOjR7MECzOFQ>
DA-3M1npRWN6fG:2b4jpZ{BCe3OjeR?=NXnhV3h7PjBizszNMnyzNlQhcA>?MVTJR|UxRTRizszNNWTSbFU6OjR7MEC2Olg>
DA-3Mlu1SpVv[3Srb36gRZN{[Xl?M3PkU|ExKM7:TR?=NXPSZ3ZYOTBiaB?=NEH6[m9E\WyudXzhdkB2eHSja3WgbY4hdW:3c3WgSGEuOyClZXzsJI1qfG:laH;u[JJq[Q>?MoXINlQ6ODB4Nki=
DA-3NX7JelZLTnWwY4Tpc44hSXO|YYm=MorSNVAh|ryPNEm1[ZoyOCCqMoCxR4VtdHWuYYKgeZB1[WunIHnuJI1wfXOnIFTBMVMh[2WubDDsfZNwe2:vZR?=M3\Mb|I1QTByNk[4
DA-3NX;ESo83TnWwY4Tpc44hSXO|YYm=NU\MZVFbOTBizszNM3SzPFExKGh?M3zIZWNmdGy3bHHyJJVxfGGtZTDpckBud3W|ZTDERU0{KGOnbHygcpVkdGW3cx?=MlTUNlQ6ODB4Nki=
YOYO1MmnwSpVv[3Srb36gRZN{[Xl?NF7ZPFlFcXOybHHj[Y1mdnRib3[gXW9[VzFiZoLvcUBxcGGpZTDsZY1j\GFiRF7BJJdqfGhiSVO1NEBw\iByLk[g{txOM3TOUVI1QTByNk[4
KCL22NHHLfYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NYTuU2FvPDhiaB?=MVrJR|UxRTFwODFOwG0>NFfvcpozPDl2MUGyPS=>
Saos2M1TRfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M1njbVQxKM7:TR?=M2fqRVI1KGh?MXPEUXNQM4fyd2lEPTB;MD6zN{DPxE1?MY[yOFk1OTF|MB?=
IMR32MnX3R5l1d3SxeHnjJGF{e2G7NFTJOHgzPTBizszNNEL5XY41QCCqMn;3SG1UVw>?M{n6WmlEPTB;MD6wNFUyKM7:TR?=M2T2TVI1QTl4MUSw
NTERA-S-cl-D1NVznTGlVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NYnDOJNpUUN3ME2xMlM4KG6PNIjhepRUSU6JRWK=
EW-16MlX5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MmPmTWM2OD1zLkmxJI5OMnK3V2FPT0WU
HUTU-80NE\H[pZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M1XzS2lEPTB;Mj6xNkBvVQ>?NETuPXlUSU6JRWK=
KS-1M{LpcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7Ml;nTWM2OD1|LkS0JI5OMYPTRW5ITVJ?
HT-144NH60d5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NYLJSnpOUUN3ME2zMlUyKG6PMWnTRW5ITVJ?
MFH-inoNWm5cG9LT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MWfJR|UxRTNwOUmgcm0>Mn;xV2FPT0WU
LC-2MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M2mzXGlEPTB;NT6wO{BvVQ>?MW\TRW5ITVJ?
SW982MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MYLJR|UxRTZwMEWgcm0>MnLnV2FPT0WU
ES4MkHiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NFzzSm1KSzVyPU[uNVEhdk1?NYjwR3p1W0GQR1XS
KGNMYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MmrvTWM2OD14LkO0JI5ONX7jNIdKW0GQR1XS
RH-1NILKSnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=Mn7NTWM2OD14LkezJI5OMWfTRW5ITVJ?
IGROV-1MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NFi0XJJKSzVyPUeuNkBvVQ>?M4XCOXNCVkeHUh?=
KYSE-270NIj0dlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NVLRW5BlUUN3ME23MlIyKG6PNVP6UYhNW0GQR1XS
TE-8MmXIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NIi2UXdKSzVyPUeuOUBvVQ>?M1XUPXNCVkeHUh?=
DaoyNXuxWGdLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NGThVo9KSzVyPUiuNFchdk1?NGj6bIFUSU6JRWK=
REHMULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M3fYXGlEPTB;OD6xNUBvVQ>?MkHSV2FPT0WU
786-0NHPiRotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MkLiTWM2OD16LkS3JI5OMoHaV2FPT0WU
A375M1HpRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NGnpWVhKSzVyPUmuNVchdk1?NGS2TVRUSU6JRWK=
EW-13NEm1fXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M1\Mc2lEPTB;OT62N{BvVQ>?Mor0V2FPT0WU
MKN1MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M3iydGlEPTB;OT64OkBvVQ>?MV\TRW5ITVJ?
MV-4-11NIewenZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M3PqVGlEPTB;MUCuNFMhdk1?NXTHcGtnW0GQR1XS
ESS-1M3;O[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MWPJR|UxRTFzLkC5JI5OM2H6O3NCVkeHUh?=
PSN1M1\NNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NIfkWWlKSzVyPUGxMlIzKG6PMYXTRW5ITVJ?
MCF7NHrw[oZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MmDqTWM2OD1zMT62OUBvVQ>?NVTSeIRMW0GQR1XS
A427MlLqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MoLYTWM2OD1zMT64NUBvVQ>?M1jYTXNCVkeHUh?=
NCI-H1651NHLYRZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MWPJR|UxRTFzLkizJI5ONIHKelNUSU6JRWK=
LCLC-97TM1M{DzV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MnrsTWM2OD1zMT64N{BvVQ>?MnH0V2FPT0WU
DU-4475MoWyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MojPTWM2OD1zMj6xJI5OMknjV2FPT0WU
SK-LU-1MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M3LsfWlEPTB;MUKuOVQhdk1?NI\nO3NUSU6JRWK=
NCI-H460Mlv6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NYXxTVNrUUN3ME2xNk44KG6PMm\SV2FPT0WU
A204M3HFOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NHjBepZKSzVyPUGyMlg5KG6PNE\IU41USU6JRWK=
AGSMni3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MYLJR|UxRTF|LkK3JI5ONIK0[5RUSU6JRWK=
NCI-H2228Mk\mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NGDVbJNKSzVyPUGzMlQ5KG6PNID0eW9USU6JRWK=
HGC-27MlLLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MYLJR|UxRTF|LkW2JI5OMl7UV2FPT0WU
RPMI-2650NXfTU|lMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M4nGO2lEPTB;MUOuOlkhdk1?MVrTRW5ITVJ?
ES1NGPWV|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MXPJR|UxRTF|LkeyJI5OMoPyV2FPT0WU
MEL-JUSOMn;5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MVHJR|UxRTF2LkWgcm0>MXPTRW5ITVJ?
HT-1080NWq4ZVFPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NYPtVpFFUUN3ME2xOE45OiCwTR?=NI\F[GZUSU6JRWK=
OCUB-MMonlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MlnNTWM2OD1zNT6xOUBvVQ>?NHn5TW5USU6JRWK=
23132-87MmnKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NELpTYdKSzVyPUG1MlQzKG6PNVHTW3ZRW0GQR1XS
KYSE-510MnLqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MkG1TWM2OD1zNT60PEBvVQ>?MmHSV2FPT0WU
ST486MlfDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NFruXoFKSzVyPUG1MlU{KG6PNXzNUIs6W0GQR1XS
639-VMkDoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MXLJR|UxRTF3LkmxJI5OMmLUV2FPT0WU
COLO-679NH3XSGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MXfJR|UxRTF3Lkm3JI5OMWHTRW5ITVJ?
CTV-1MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M4X5cGlEPTB;MU[uNFchdk1?NHH2eYRUSU6JRWK=
BFTC-905NYrkW3JtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NV7Kc2RCUUN3ME2xOk4yQCCwTR?=M2nkNnNCVkeHUh?=
SW954NYLIbYtvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MkCyTWM2OD1zNj65N{BvVQ>?MVXTRW5ITVJ?
CAL-51Ml\rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MnSzTWM2OD1zNz6zNkBvVQ>?M12ydHNCVkeHUh?=
SW1710Ml64S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NWLEN5RSUUN3ME2xO{41KG6PNUiwTZFPW0GQR1XS
HCC2998MnPHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MXHJR|UxRTF5LkS0JI5OM{P5bHNCVkeHUh?=
A2058Mlq2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MXjJR|UxRTF5Lk[1JI5OM3XDPHNCVkeHUh?=
HCE-4MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NF7RV4dKSzVyPUG4MlA4KG6PNYHCbJFyW0GQR1XS
MEL-HOM2P0[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MYfJR|UxRTF6LkOgcm0>MXnTRW5ITVJ?
SNG-MMlfXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NHLlXmNKSzVyPUG4MlMzKG6PMoLWV2FPT0WU
LS-123MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MlW2TWM2OD1zOD60OkBvVQ>?M{i0enNCVkeHUh?=
NALM-6MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NX;rcGM{UUN3ME2xPE43OyCwTR?=MVfTRW5ITVJ?
NCI-H810MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NEDqbm9KSzVyPUG4Mlc3KG6PMX\TRW5ITVJ?
YKG-1NFf1SoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NE\wdWJKSzVyPUG4Mlc4KG6PNXjGO5N4W0GQR1XS
647-VMoTnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?Ml60TWM2OD1zOD64NUBvVQ>?MWHTRW5ITVJ?
ONS-76MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NYe2VVgyUUN3ME2xPE46OSCwTR?=MmnPV2FPT0WU
697NH7FbWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M1O5OGlEPTB;MUmuNFkhdk1?MoLLV2FPT0WU
RS4-11Mk\IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NWT6SHBGUUN3ME2xPU4yPCCwTR?=M1TD[XNCVkeHUh?=
8505CM2jybmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M3zj[GlEPTB;MUmuOVYhdk1?NY\Ed2hiW0GQR1XS
SK-UT-1NYnqTIhLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NH;NV3FKSzVyPUG5Mlk3KG6PMUnTRW5ITVJ?
DOHH-2NF;qNIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NX\GTFZrUUN3ME2xPU46QSCwTR?=MkDaV2FPT0WU
NCCITNX34coo6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MmLzTWM2OD1{MD6xN{BvVQ>?MVLTRW5ITVJ?
LCLC-103HNEH0XW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MWrJR|UxRTJyLkW0JI5OM3nwXHNCVkeHUh?=
CAL-12TMnLzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M1jBOGlEPTB;MkCuOlUhdk1?Mo[xV2FPT0WU
QIMR-WILNEHiNZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MXPJR|UxRTJyLkeyJI5ONUf3cZdZW0GQR1XS
SBC-5NYTE[3V{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MmLvTWM2OD1{MD63OEBvVQ>?MVjTRW5ITVJ?
769-PMm\oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NGT5dWNKSzVyPUKwMlc3KG6PMYLTRW5ITVJ?
A431NVzxNoV5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NVLtdFRCUUN3ME2yNE45PyCwTR?=NF;iSmZUSU6JRWK=
KE-37MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M{fKXGlEPTB;MkGuNFUhdk1?MWXTRW5ITVJ?
ES8NFG1fW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MkD5TWM2OD1{MT6wO{BvVQ>?NHy4OoNUSU6JRWK=
22RV1MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MmjoTWM2OD1{MT6yOEBvVQ>?MWTTRW5ITVJ?
LOUCYMlfjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NXGwR|c6UUN3ME2yNU4{OiCwTR?=M4nGRnNCVkeHUh?=
J82MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MkfxTWM2OD1{MT6zOEBvVQ>?MV3TRW5ITVJ?
MHH-ES-1NV;lSHk4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NWXzV492UUN3ME2yNU42QCCwTR?=M1nycXNCVkeHUh?=
MG-63NGjmd3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=Ml2zTWM2OD1{Mj6wPEBvVQ>?MYLTRW5ITVJ?
8-MG-BANUC1UJNiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NGPlO2pKSzVyPUKyMlEzKG6PNYjhUG9kW0GQR1XS
BPH-1NEjSRZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=Mn7UTWM2OD1{Mj6xNkBvVQ>?MXHTRW5ITVJ?
RKOMn7xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NEGxR5FKSzVyPUKyMlI5KG6PMofFV2FPT0WU
HMV-IINIfFSVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NHG3cnFKSzVyPUKyMlYhdk1?MmS2V2FPT0WU
NCI-H727NXvUNnBxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=Ml7OTWM2OD1{Mj63PUBvVQ>?MnzTV2FPT0WU
MOLT-4NVy0TpZDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NETrSIhKSzVyPUKyMlg3KG6PM2fve3NCVkeHUh?=
NCI-H2342MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M1Xwd2lEPTB;MkKuPVEhdk1?MVfTRW5ITVJ?
MZ1-PCMXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NFv0fotKSzVyPUKzMlgyKG6PNHTL[IlUSU6JRWK=
TE-15MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NX74XZBHUUN3ME2yOE4yPCCwTR?=MnS3V2FPT0WU
SRNUO5PIJDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MVvJR|UxRTJ2LkSxJI5OM{HNc3NCVkeHUh?=
CCRF-CEMMYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MYPJR|UxRTJ2LkWyJI5OMWnTRW5ITVJ?
SIG-M5Ml3wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MU\JR|UxRTJ3Lk[5JI5ONYDLdJNmW0GQR1XS
SK-PN-DWMVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NXPUc2tJUUN3ME2yOU44OiCwTR?=NICwUZhUSU6JRWK=
SK-HEP-1MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NUXXb3RxUUN3ME2yOU45PiCwTR?=NWTWWW5yW0GQR1XS
SW620M{jRSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NH\zU3NKSzVyPUK2MlY{KG6PMnj2V2FPT0WU
HSC-2M3zmTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M{XLfWlEPTB;Mk[uO|ghdk1?NHLNRYRUSU6JRWK=
CAL-148MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MVjJR|UxRTJ4Lkmgcm0>MnTkV2FPT0WU
COLO-205MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NEW4b4FKSzVyPUK2Mlk6KG6PM4XucXNCVkeHUh?=
EoL-1-cellMUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M1SwfWlEPTB;MkeuO|ghdk1?M1K3cHNCVkeHUh?=
KYSE-150NV;3UW1TT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MULJR|UxRTJ5Lke4JI5OMWHTRW5ITVJ?
G-361MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?Ml3NTWM2OD1{OD64PEBvVQ>?NGm2TpNUSU6JRWK=
PANC-03-27NGDZeoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M32xR2lEPTB;MkiuNVYhdk1?MYjTRW5ITVJ?
NCI-H2030MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NHG3XpFKSzVyPUK4MlI3KG6PNF\5cG9USU6JRWK=
NCI-H441NGP6ZoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M32ybmlEPTB;MkiuOFIhdk1?M{PFRXNCVkeHUh?=
A388NX7TTVMxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MX3JR|UxRTJ6LkS2JI5OM4fDNXNCVkeHUh?=
BHYMX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MV;JR|UxRTJ6Lki4JI5ONX2xUJJKW0GQR1XS
KALS-1M37XZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NWTKb5htUUN3ME2yPU4{OyCwTR?=NGrETVBUSU6JRWK=
NKM-1Mo\US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MWTJR|UxRTJ7LkS3JI5OMY\TRW5ITVJ?
BB30-HNCNFXnRlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NInOUHVKSzVyPUK5Mlg2KG6PMVzTRW5ITVJ?
G-401NHrpd|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MofwTWM2OD1|MD6yJI5OMY\TRW5ITVJ?
EW-7NUHFO|VTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NHm5Z|ZKSzVyPUOwMlY{KG6PNV65SoxvW0GQR1XS
CANNFXUUlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M1nBW2lEPTB;M{GuNVIhdk1?NX;JZpZiW0GQR1XS
M059JNWe4UpBxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MnHUTWM2OD1|MT6zO{BvVQ>?MYTTRW5ITVJ?
SK-MES-1MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NVPUbpV7UUN3ME2zNU42KG6PNVjHVHBxW0GQR1XS
5637NF60UmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MmHjTWM2OD1|MT64O{BvVQ>?MULTRW5ITVJ?
MKN28MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MXHJR|UxRTNzLkmxJI5ONFnqPGZUSU6JRWK=
COR-L23NEXXNVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M{PuNWlEPTB;M{GuPVYhdk1?MXvTRW5ITVJ?
CAL-27Mm[1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NV7GZoRuUUN3ME2zNk42PyCwTR?=NYHTeFNbW0GQR1XS
CAL-62NWTvSW1QT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MXHJR|UxRTN{Lke5JI5OM4DUXHNCVkeHUh?=
C-33-ANEnFOYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M1;HcWlEPTB;M{KuPFkhdk1?MlflV2FPT0WU
RT-112NF;SSYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M4jHO2lEPTB;M{KuPVIhdk1?NX7uUItoW0GQR1XS
KU812MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M{LYN2lEPTB;M{OuNlQhdk1?MnfjV2FPT0WU
C8166M3\i[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7Mn:2TWM2OD1|Mz6zNUBvVQ>?M1XoVnNCVkeHUh?=
VA-ES-BJNWDUc3dIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NHfO[JlKSzVyPUOzMlM3KG6PMVHTRW5ITVJ?
NEC8MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NWO2fm9UUUN3ME2zN{43OSCwTR?=NVnLXmN1W0GQR1XS
EB2MnvZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MYfJR|UxRTN|LkezJI5OM1T6ZnNCVkeHUh?=
COLO-680NM2P3bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M{LZRmlEPTB;M{OuPFchdk1?MW\TRW5ITVJ?
IGR-1M2\vcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M{HlUGlEPTB;M{OuPFMhdk1?NEPtNoJUSU6JRWK=
MZ2-MELNXTHTZJNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MX7JR|UxRTN|LkmyJI5OMmTiV2FPT0WU
MIA-PaCa-2NYXhXFJlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MVzJR|UxRTN2LkK0JI5ONYDBfoppW0GQR1XS
IMR-5M33WbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MmXxTWM2OD1|ND62PEBvVQ>?MWPTRW5ITVJ?
CHP-212MlrpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MWTJR|UxRTN2Lkm2JI5ONG\6VW1USU6JRWK=
CCF-STTG1M{DxR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NHK3UJBKSzVyPUO1MlUhdk1?M{DtTnNCVkeHUh?=
SK-MEL-30M2r6VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MmSzTWM2OD1|NT62NUBvVQ>?NILWXopUSU6JRWK=
HLEM2roZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M4\HWWlEPTB;M{WuPEBvVQ>?MlXWV2FPT0WU
HOP-62NH;OU2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MkXwTWM2OD1|NT64PEBvVQ>?M4XXV3NCVkeHUh?=
LB1047-RCCM1jpVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M2fDZ2lEPTB;M{WuPVchdk1?MmW2V2FPT0WU
DoTc2-4510M3HobGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MUjJR|UxRTN4LkK1JI5ONFPpe5JUSU6JRWK=
HT-29NXLxemV7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NXjHUJZMUUN3ME2zOk42PyCwTR?=NFP2fZBUSU6JRWK=
HC-1M3nyZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NUP4bGZyUUN3ME2zO{4{OiCwTR?=M3jEVXNCVkeHUh?=
TE-5NISw[GhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MWTJR|UxRTN5LkS4JI5OMkLoV2FPT0WU
NCI-H1299Ml7jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NEj4UnRKSzVyPUO3MlU6KG6PMkS4V2FPT0WU
CHL-1NXHSe2VwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NYTabmR1UUN3ME2zO{44OyCwTR?=NYXvUZFOW0GQR1XS
NCI-H2122Mne2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NFPW[3dKSzVyPUO3Mlkhdk1?NYH0T2pnW0GQR1XS
DELM37NTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NYDLV5ZHUUN3ME2zPE41PCCwTR?=NVn5TJJYW0GQR1XS
ES5NGLiOY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MXzJR|UxRTN7LkKyJI5ONUX5[5JiW0GQR1XS
CESSM13TZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NF3qclFKSzVyPUO5MlM3KG6PM4H5cXNCVkeHUh?=
NCI-H719MmDKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NEHLUFlKSzVyPUO5MlY2KG6PMV\TRW5ITVJ?
A3-KAWNXXCb2RGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NFjMS2NKSzVyPUSwMlE1KG6PM{\tSXNCVkeHUh?=
KP-4M2\OPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MmTBTWM2OD12MD63O{BvVQ>?MXrTRW5ITVJ?
NCI-H358MojIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NFzaSphKSzVyPUSxMlA5KG6PMWfTRW5ITVJ?
HCC38NXfuS4I6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NWfIVYRVUUN3ME20Nk42KG6PNIS0SHJUSU6JRWK=
MRK-nu-1MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MmLlTWM2OD12Mz62OkBvVQ>?MmSyV2FPT0WU
NCI-H292NYTtXI4xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MUjJR|UxRTR|Lke2JI5OM3\pOHNCVkeHUh?=
PA-1NGHl[mdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M3qyWWlEPTB;NESuOFghdk1?M3n2b3NCVkeHUh?=
CAL-85-1MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NWG0[3A1UUN3ME20OE42OiCwTR?=MUPTRW5ITVJ?
KYSE-450MnHmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M4XK[2lEPTB;NESuO|Ehdk1?NWfMeXpqW0GQR1XS
IST-MEL1NVH6VoxyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NUntO2djUUN3ME20OE45PCCwTR?=NV7zemF4W0GQR1XS
Ca-SkiM3SyNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NYnBW5F1UUN3ME20OE45PCCwTR?=NVW1Z28xW0GQR1XS
OCI-AML2NFTvcZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MVXJR|UxRTR3LkC1JI5OMUPTRW5ITVJ?
NUGC-3M2H5Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NHnKc5NKSzVyPUS1MlIhdk1?MlLHV2FPT0WU
HOSMX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NVrlUpNVUUN3ME20OU4zQSCwTR?=M2fkT3NCVkeHUh?=
NB1MkLqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M{XBTWlEPTB;NEWuPVkhdk1?M{\EdHNCVkeHUh?=
A253M4nkOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MWPJR|UxRTR4LkGyJI5OMnzjV2FPT0WU
NCI-H209NYDrV|cxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NH7uVGJKSzVyPUS4Mlc{KG6PM4XjSnNCVkeHUh?=
MC-CARNHjkOmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MVXJR|UxRTR6Lke0JI5OMULTRW5ITVJ?
NCI-H661NWfXc4N4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NYDqeZlGUUN3ME20PU4xOyCwTR?=MVPTRW5ITVJ?
SF295M2jtR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MUTJR|UxRTR7LkC4JI5OM4fXOnNCVkeHUh?=
GP5dNXnnSYpmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M3PLXGlEPTB;NEmuNVIhdk1?NWD5c21rW0GQR1XS
P12-ICHIKAWAMXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NGTkfWdKSzVyPUS5MlI4KG6PNIHMbYZUSU6JRWK=
ACHNMkLxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M17WbmlEPTB;NEmuN|Qhdk1?MnHZV2FPT0WU
NCI-H2087MmPZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MWfJR|UxRTR7LkSyJI5OMUTTRW5ITVJ?
SW48NEj3N5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NXjRc2RNUUN3ME20PU44OiCwTR?=MV7TRW5ITVJ?
NCI-H526MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NFfCbIlKSzVyPUS5Mlk3KG6PMWTTRW5ITVJ?
Ca9-22Moq0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NFnaOW9KSzVyPUWwMlA4KG6PNX3y[XNFW0GQR1XS
SK-OV-3MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?Mni4TWM2OD13MD6xNkBvVQ>?MUnTRW5ITVJ?
KYSE-140M1q4VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NYfUSWZDUUN3ME21NE41OiCwTR?=NVflUFI3W0GQR1XS
BE-13MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NGO4[|BKSzVyPUWxMlAzKG6PNHPPR|NUSU6JRWK=
ES7MkfTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NYLpUpB6UUN3ME21NU41KG6PNUPCZXA3W0GQR1XS
IM-9MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NI\BRm5KSzVyPUWxMlQ{KG6PNH\V[oxUSU6JRWK=
A101DNXLrU5F1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MoLZTWM2OD13MT60PEBvVQ>?NX;DWJVFW0GQR1XS
CAPAN-1NHnD[2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NH\yc4JKSzVyPUWxMlc3KG6PNFnJcZdUSU6JRWK=
NCI-H2009NHfwS5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NUf2e2FPUUN3ME21NU44PiCwTR?=NYG2PZpYW0GQR1XS
NCI-H522NXv2TIRJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NFrzUGVKSzVyPUWxMlk{KG6PM{LKdnNCVkeHUh?=
HuP-T4NVfDO3NOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NXfVXYpwUUN3ME21Nk4zOiCwTR?=NUix[mJZW0GQR1XS
BCPAPMmXGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M1exRmlEPTB;NUKuOUBvVQ>?M4T5dXNCVkeHUh?=
NCI-H1734NFLkWoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M1PZZWlEPTB;NUOgcm0>MlTsV2FPT0WU
SK-LMS-1M1vGcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M2XTbGlEPTB;NUOuNlIhdk1?MmjZV2FPT0WU
CGTH-W-1NHjsW4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=Ml;6TWM2OD13Mz60OkBvVQ>?MVvTRW5ITVJ?
RPMI-8402NYfPVmlKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NVzYVlNDUUN3ME21N{45PiCwTR?=MXfTRW5ITVJ?
Calu-3NETXd|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NYDpXW01UUN3ME21OU46QCCwTR?=NW\EZYl6W0GQR1XS
COR-L279NUHLNmxTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NVHDWW9KUUN3ME21Ok46PSCwTR?=MUfTRW5ITVJ?
T84MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NXGxN4ROUUN3ME21O{4xPiCwTR?=NIfaV3VUSU6JRWK=
P30-OHKNYi1fHBwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NIXKWpJKSzVyPUW3MlU4KG6PNXXVV|l5W0GQR1XS
CHP-126NXXVRWw3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MkfUTWM2OD13OT6yOEBvVQ>?NHLKZ4lUSU6JRWK=
KYSE-180NX\zfHJGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M174bmlEPTB;NUmuO|Uhdk1?MYHTRW5ITVJ?
CAMGNGfTPG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=Mo\STWM2OD13OT65OkBvVQ>?NUTSNpZOW0GQR1XS
EW-1NFvNbHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NHvJUWlKSzVyPU[xMlM2KG6PM1jyVnNCVkeHUh?=
OVCAR-8NXPrW3M3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M4nVSmlEPTB;NkGuPVIhdk1?M3XueHNCVkeHUh?=
HL-60Ml;WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MXLJR|UxRTZ{LkW2JI5OMXfTRW5ITVJ?
8305CNIf3bm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M2HMU2lEPTB;NkOuNVIhdk1?MXfTRW5ITVJ?
IA-LMM{[w[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MkPBTWM2OD14Mz61OEBvVQ>?NXXkTIUxW0GQR1XS
HCC2157Mn3jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M1zTSWlEPTB;NkOuPVUhdk1?MkD4V2FPT0WU
CTB-1MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NXzUOnBIUUN3ME22OFAyQSCwTR?=MUfTRW5ITVJ?
NCI-H1437MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MWfJR|UxRTZ2Lk[0JI5ONUDDXFd[W0GQR1XS
U251NWK4PYJDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M{m0SmlEPTB;NkSuPFkhdk1?MVfTRW5ITVJ?
ALL-PONVfGbVllT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MVvJR|UxRTZ3LkCzJI5ONHXjeJlUSU6JRWK=
NCI-SNU-1MkfVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NVf0enI2UUN3ME22OU45PiCwTR?=NUjOT5gyW0GQR1XS
RPMI-6666NFO2coNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NETzTlhKSzVyPU[1Mlk6KG6PM3P0TXNCVkeHUh?=
DBTRG-05MGMnHmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M3[xPGlEPTB;NkeuNVEhdk1?M4X6ZnNCVkeHUh?=
PF-382NVLBfo9iT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NFnlPFVKSzVyPU[3MlE4KG6PNUnHXFQxW0GQR1XS
GT3TKBM37sWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7Mn3tTWM2OD14Nz6xPUBvVQ>?M{LLUnNCVkeHUh?=
SCC-3MnH5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MkeyTWM2OD14Nz6yPEBvVQ>?NEXJVotUSU6JRWK=
LU-134-ANVLIOWdKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NF3WSGhKSzVyPU[3MlY5KG6PNFO2SFNUSU6JRWK=
CAL-33MnO3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MYLJR|UxRTZ5Lki3JI5ONVm2PZZkW0GQR1XS
MC-IXCNGPRS21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M1z4XGlEPTB;NkeuPUBvVQ>?M1O5b3NCVkeHUh?=
CPC-NMX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?Ml\pTWM2OD14OD60JI5OM{nTTnNCVkeHUh?=
A2780MkfsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M4D6Z2lEPTB;NkiuO|khdk1?MWfTRW5ITVJ?
DaudiM3qxTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NGK4WpZKSzVyPU[4Mlk3KG6PNHrNS3JUSU6JRWK=
GI-1NGO1eZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M37zWmlEPTB;NkmuOlUhdk1?M{POc3NCVkeHUh?=
SW962MnznS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NX\mWXFJUUN3ME22PU46PSCwTR?=NFLPTXBUSU6JRWK=
MFE-296MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M2\sVGlEPTB;N{CuOFkhdk1?MWXTRW5ITVJ?
H4NH25O5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MljwTWM2OD15MT61OkBvVQ>?MYXTRW5ITVJ?
AN3-CAMVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?Ml3mTWM2OD15Mj6zNkBvVQ>?M3XpZnNCVkeHUh?=
HCC1599M4fYZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7M2LqfmlEPTB;N{KuOVQhdk1?MXfTRW5ITVJ?
HuCCT1MlvjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NGrEcYhKSzVyPUeyMlk{KG6PM3:yfXNCVkeHUh?=
Calu-1NXLKRYVPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NWrDc4NMUUN3ME23N{43KG6PNH7TTZlUSU6JRWK=
DU-145NFHDZ3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MV7JR|UxRTd|LkezJI5ONUPVWlVKW0GQR1XS
IST-SL2NX3HXmE{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NVTMcI9IUUN3ME23N{45OSCwTR?=NWXz[lRLW0GQR1XS
HSC-3MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?Ml;ITWM2OD15ND61N{BvVQ>?NFi4VpJUSU6JRWK=
HCC1806MmHnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MUTJR|UxRTd2Lkm2JI5OMlrrV2FPT0WU
VM-CUB-1MmrTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NF24R3pKSzVyPUe1MlM3KG6PNUP3S5BqW0GQR1XS
HSC-4NFr6XnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M3XneWlEPTB;N{WuO|Yhdk1?NV21cHFDW0GQR1XS
NH-12M4PL[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MW\JR|UxRTd4IH7NMWDTRW5ITVJ?
MDA-MB-468NW\UO|A6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NH;IXINKSzVyPUe2MlE5KG6PMUPTRW5ITVJ?
TURNVnFWWQxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NYDLSYdtUUN3ME23Ok4{OiCwTR?=MnXhV2FPT0WU
TE-1NYr6TXBuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NV;qOHI5UUN3ME23Ok4{PSCwTR?=NVuzOnUzW0GQR1XS
CMKM{HQN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NIPsZYlKSzVyPUe3MlQzKG6PMoTPV2FPT0WU
LB996-RCCNITCUoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MmjXTWM2OD15OD60OUBvVQ>?NV35eZJDW0GQR1XS
NCI-H1650M1Ptbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M1Pvb2lEPTB;N{iuOlIhdk1?MlmyV2FPT0WU
DMS-273Ml\WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NH\ERoNKSzVyPUe4Mlkhdk1?M1\UWHNCVkeHUh?=
NOS-1MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M2PNcWlEPTB;N{muNVQhdk1?MXrTRW5ITVJ?
NB69MoHWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MWXJR|UxRTd7LkKgcm0>MXnTRW5ITVJ?
SUP-T1NV3FdZhtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MUHJR|UxRTd7LkeyJI5OM2CzbnNCVkeHUh?=
A172NYj3eFFyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NH7WbmRKSzVyPUiwMlU2KG6PMlLNV2FPT0WU
TE-12M3;RdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M3m4R2lEPTB;OEGuNFYhdk1?NIjrTGdUSU6JRWK=
MKN45NF3hZYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MXvJR|UxRThzLkWxJI5OMkj3V2FPT0WU
LoVoNIXsXWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MoC0TWM2OD16MT64NkBvVQ>?M{HsVXNCVkeHUh?=
SW1573MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NGD0XpNKSzVyPUiyMlgyKG6PMoXlV2FPT0WU
ETK-1MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M4LNNmlEPTB;OEOuNFEhdk1?NVK3SmZ{W0GQR1XS
ABC-1NXH6VVNwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MkDnTWM2OD16Mz60OUBvVQ>?M3HZeHNCVkeHUh?=
COLO-668NGTmWIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MWLJR|UxRTh2LkS3JI5OMV\TRW5ITVJ?
UM-UC-3NVnxd3dpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MUXJR|UxRTh4LkCyJI5OMnnRV2FPT0WU
BC-1M3XDVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NGP2d2hKSzVyPUi2Mlc3KG6PM{nhfXNCVkeHUh?=
PANC-10-05NILQSo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NYTxNnNpUUN3ME24PE41PSCwTR?=NUnTcJd[W0GQR1XS
ES3NX3vU481T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MlTXTWM2OD16OT60PEBvVQ>?Ml:2V2FPT0WU
TE-441-TNH7iNG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NXX3XYJIUUN3ME24PU45OiCwTR?=MYLTRW5ITVJ?
KM-H2NEnzXVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MXPJR|UxRTlyLk[4JI5ONXr1UWFoW0GQR1XS
SH-4M1rsdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MmTpTWM2OD17Mj6xNUBvVQ>?M2rxbXNCVkeHUh?=
SF268MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MojpTWM2OD17Mj60NkBvVQ>?MVXTRW5ITVJ?
VMRC-RCZNILadYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=Mlz3TWM2OD17Mz6yOkBvVQ>?M{flVnNCVkeHUh?=
GI-ME-NMni2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NYLrdZZvUUN3ME25N{4{OyCwTR?=MX\TRW5ITVJ?
JEG-3M3fZUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MUPJR|UxRTl3LkGyJI5OMW\TRW5ITVJ?
J-RT3-T3-5MlnyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MnTjTWM2OD17Nj6zNUBvVQ>?MULTRW5ITVJ?
K5NHrCTYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MkTITWM2OD17Nj65JI5ONWK4bXN4W0GQR1XS
EFO-27NXHXO202T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NW\nTZNHUUN3ME25O{41PCCwTR?=M2WwRnNCVkeHUh?=
SW1783MnPiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MWDJR|UxRTl5Lkm5JI5OMXrTRW5ITVJ?
CAL-39NVPBToFQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NVX3W5hMUUN3ME25PE4zPCCwTR?=MoDoV2FPT0WU
LS-441NM2WzRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MkHDTWM2OD17OT6wOkBvVQ>?M1e5[3NCVkeHUh?=
G-402MnvjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NGHFOmxKSzVyPUm5MlA6KG6PMXnTRW5ITVJ?
MES-SAM4qxNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MlrTTWM2OD17OT61N{BvVQ>?MULTRW5ITVJ?
FADUNFjNWJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NG\tOo1KSzVyPUGwNk4yQCCwTR?=NHexcm9USU6JRWK=
DJM-1NWHIclVzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=Mle2TWM2OD1zMEKuNlUhdk1?NX7BTpBVW0GQR1XS
SU-DHL-1MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MXrJR|UxRTFyMj61JI5OMXnTRW5ITVJ?
KYSE-410Mn3qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M4\YRWlEPTB;MUCzMlQ3KG6PNILSVVJUSU6JRWK=
NCI-H1618NUTDPWVbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NHPqPJBKSzVyPUGwOE4{PSCwTR?=NIfI[4RUSU6JRWK=
AU565MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NX3ZUmR6UUN3ME2xNFQvPTFibl2=MV7TRW5ITVJ?
SF126MlPSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?Mnf4TWM2OD1zMESuOVghdk1?MWLTRW5ITVJ?
MMAC-SFNVi0VZRlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NHnZe5ZKSzVyPUGwOk41QCCwTR?=MVvTRW5ITVJ?
ChaGo-K-1MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?Mk\FTWM2OD1zMEeuPVUhdk1?Ml;tV2FPT0WU
NCI-H596MkjwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M2XTcWlEPTB;MUC4MlAyKG6PM2XYdHNCVkeHUh?=
LXF-289NGTVUJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NUnGVVZYUUN3ME2xNFkvOjRibl2=MmCzV2FPT0WU
HCC1569MlP4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MmTMTWM2OD1zMEmuN|Qhdk1?MVLTRW5ITVJ?
NCI-H2170M37yOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MXjJR|UxRTFyOT65NkBvVQ>?M{L0TnNCVkeHUh?=
ARH-77MkXxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MYDJR|UxRTFyOT65PUBvVQ>?M{naN3NCVkeHUh?=
BOKUMYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MnPVTWM2OD1zMUCuPFchdk1?Ml;nV2FPT0WU
SJSA-1MlHSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MYLJR|UxRTFzMT6wOUBvVQ>?NEjaenlUSU6JRWK=
SW626NEfHSm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M{XxcmlEPTB;MUGxMlcyKG6PM1nle3NCVkeHUh?=
EHEBNF3SV5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MWnJR|UxRTFzMj61PUBvVQ>?NW\6ZY9kW0GQR1XS
TE-10MoGzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MlPBTWM2OD1zMUKuOlghdk1?MVTTRW5ITVJ?
MZ7-melNF3sXXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MWrJR|UxRTFzMj64OEBvVQ>?NXS1XXVJW0GQR1XS
SASMmLUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M{nMRmlEPTB;MUG0MlQ2KG6PNGjmPZRUSU6JRWK=
TK10MoPwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NX3sT29WUUN3ME2xNVQvPiCwTR?=NFfpfoNUSU6JRWK=
SW13M{P5R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7M{LDN2lEPTB;MUG1MlI3KG6PNWPYWWRFW0GQR1XS
HCC1937MnT6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MlTJTWM2OD1zMUWuPFQhdk1?M{HENHNCVkeHUh?=
SK-NEP-1M{LTZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MXHJR|UxRTFzNj6yOkBvVQ>?NHvQRYJUSU6JRWK=
OVCAR-5M{jUSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NYfSVIVrUUN3ME2xNVYvQDFibl2=MX7TRW5ITVJ?
SW837NUD0PHZXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=Ml7XTWM2OD1zMUeuPVUhdk1?MWPTRW5ITVJ?
BFTC-909M1jFXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M1PYTmlEPTB;MUG4MlQ5KG6PM2DjdXNCVkeHUh?=
SW872NHzSOIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M3u2Z2lEPTB;MUKwMlgyKG6PNGraVZRUSU6JRWK=
SF539NUjVNpMxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MoHKTWM2OD1zMkGuO|Ihdk1?MWnTRW5ITVJ?
MLMAM1zLXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7Mke2TWM2OD1zMkKuNFghdk1?MX3TRW5ITVJ?
BL-41NGDJO2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MUHJR|UxRTF{Mj6yNkBvVQ>?M3ftbHNCVkeHUh?=
LB647-SCLCNUGzc2plT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M2fOV2lEPTB;MUKzMlM2KG6PNFLsSYhUSU6JRWK=
NCI-H1703MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NYHzNGlNUUN3ME2xNlYvPDJibl2=M1HjTXNCVkeHUh?=
KURAMOCHINX;5VYpKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M3;HZ2lEPTB;MUK2Mlc3KG6PNGXqOoRUSU6JRWK=
ATN-1M1rpT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MX7JR|UxRTF{Nz63JI5OMUjTRW5ITVJ?
SK-CO-1NY\EZplCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NFP6VYZKSzVyPUGyPU4zOSCwTR?=MmTKV2FPT0WU
RPMI-7951MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MUTJR|UxRTF|MD6xOEBvVQ>?M1nTW3NCVkeHUh?=
NCI-H1648MlPoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M1jwbWlEPTB;MUOxMlk1KG6PNHL1fmtUSU6JRWK=
NCI-H64MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MkPHTWM2OD1zM{KuOlUhdk1?NH;BWoFUSU6JRWK=
HT-3M{D3[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MXjJR|UxRTF|Mz6wOEBvVQ>?NGTsZVdUSU6JRWK=
NCI-H1770Mn3DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NEj6NWtKSzVyPUGzN{4zOSCwTR?=NIjDcGVUSU6JRWK=
NB13MkjDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MUTJR|UxRTF|ND61OUBvVQ>?M3f6NXNCVkeHUh?=
NCI-H747M1K2O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MYrJR|UxRTF|NT6wNkBvVQ>?NVH3Z3NtW0GQR1XS
ML-2M1\Qd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MVLJR|UxRTF|NT6xOkBvVQ>?MmiyV2FPT0WU
CA46NWXKU5pIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NIO2UYZKSzVyPUGzOk45QCCwTR?=NFPkfINUSU6JRWK=
ES6MnPwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MoDwTWM2OD1zM{euNVIhdk1?MWnTRW5ITVJ?
JiyoyeP-2003M4TWc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MmnDTWM2OD1zM{euPEBvVQ>?MlXyV2FPT0WU
NMC-G1M33U[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MoPoTWM2OD1zM{muNVMhdk1?M{nIPXNCVkeHUh?=
U-698-MMY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M2e3PGlEPTB;MUO5MlUhdk1?NIXTcGRUSU6JRWK=
LU-99AMVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NWjmOZROUUN3ME2xOFYvPTVibl2=M4q0SHNCVkeHUh?=
NCI-H748NELXPJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MYLJR|UxRTF2Nz6zNUBvVQ>?NIe1UXBUSU6JRWK=
SK-MEL-3M{XJZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NFfod5dKSzVyPUG0O{43OSCwTR?=M1PRVXNCVkeHUh?=
SNB75MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MmW4TWM2OD1zNEiuOlUhdk1?NFzxdoFUSU6JRWK=
BB65-RCCMmjGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NYTzOI93UUN3ME2xOFkvOzFibl2=M3r0NnNCVkeHUh?=
NCI-H1355NILVV4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NGLVelBKSzVyPUG1Nk4zPCCwTR?=M{TFb3NCVkeHUh?=
SCC-25M4XDWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NFnPRmdKSzVyPUG1N{44OyCwTR?=MVnTRW5ITVJ?
OAW-42NH3aTWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NWTFR2JIUUN3ME2xOVMvQDRibl2=MnTmV2FPT0WU
MONO-MAC-6NEPiZYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MlnTTWM2OD1zNUSuN|Yhdk1?NFHWWWpUSU6JRWK=
WSU-NHLNEjwXY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MWrJR|UxRTF3ND61PEBvVQ>?NYPDdnZbW0GQR1XS
SNU-423MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MlnaTWM2OD1zNUWuN|Qhdk1?NXm3UZZ{W0GQR1XS
SBC-1MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NEHESmhKSzVyPUG1Ok41KG6PNVjNflFWW0GQR1XS
OVCAR-4MnjMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MkGyTWM2OD1zNU[uO|ghdk1?M2jyUHNCVkeHUh?=
NCI-H2347NHnaVndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MojyTWM2OD1zNUiuN|Qhdk1?M4HKdXNCVkeHUh?=
CAMA-1M{PQeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NXXrNHNCUUN3ME2xOVkvOzNibl2=NE\YfHFUSU6JRWK=
GDM-1NWTSNZRRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=Ml;YTWM2OD1zNUmuO{BvVQ>?M1;SdnNCVkeHUh?=
KNS-81-FDMX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NHPibI1KSzVyPUG2NE4{OiCwTR?=NYHtUFdLW0GQR1XS
no-10Mli1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NXTRd2hEUUN3ME2xOlAvOzhibl2=Ml7GV2FPT0WU
NCI-H2052M{fGS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NIj1NmNKSzVyPUG2NE41PyCwTR?=NGj2WZlUSU6JRWK=
DBM4LYfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NX\6S4dlUUN3ME2xOlEvPzFibl2=NGnveFlUSU6JRWK=
A4-FukNUnNTHZtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MoPlTWM2OD1zNkKuOFghdk1?NGHqSm1USU6JRWK=
HCE-TMUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MWPJR|UxRTF4ND64O{BvVQ>?NFTaRWpUSU6JRWK=
HuP-T3MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?Mn7oTWM2OD1zNkWuOVUhdk1?M1juZ3NCVkeHUh?=
BC-3MlyzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NV7VS4xEUUN3ME2xOlUvQDZibl2=MojlV2FPT0WU
RVH-421NVnmc2lZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MmrtTWM2OD1zNkmuNVMhdk1?M2nnWHNCVkeHUh?=
COLO-800M1zScmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MmXITWM2OD1zN{GuPEBvVQ>?M4fz[3NCVkeHUh?=
OMC-1MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MlzuTWM2OD1zN{KuNVchdk1?MWDTRW5ITVJ?
SJRH30NX21b|lTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MlX0TWM2OD1zN{KuPVQhdk1?M2nqPXNCVkeHUh?=
HELNHPseI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NFvJb4JKSzVyPUG3OU4yPSCwTR?=NFj0clhUSU6JRWK=
KLENIXqc3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MYrJR|UxRTF5NT60O{BvVQ>?M4fH[HNCVkeHUh?=
MEG-01MnHJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NVX4T2IxUUN3ME2xO|YvPiCwTR?=MVjTRW5ITVJ?
OAW-28NV[4eo5xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NUTrbY5lUUN3ME2xO|gvQDRibl2=MXjTRW5ITVJ?
RDNEjubIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MV;JR|UxRTF6MD6xJI5ONUP3bYQyW0GQR1XS
HCC2218MlvhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MoTNTWM2OD1zOEGuOlYhdk1?NVS0fXNqW0GQR1XS
OS-RC-2MoHQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MX7JR|UxRTF6Mj60PUBvVQ>?NVrGV|NUW0GQR1XS
HEC-1NXu2OmRNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MXLJR|UxRTF6Mj64N{BvVQ>?NYrhWYR2W0GQR1XS
SCC-4NXv0WldGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MmDETWM2OD1zOEOuO|Ehdk1?MlfEV2FPT0WU
ME-180M2rvTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NVu0bZhvUUN3ME2xPFYvODhibl2=NFSzUnVUSU6JRWK=
NB10MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M4LL[mlEPTB;MUi4MlA6KG6PM1LxbnNCVkeHUh?=
SCC-15NEXjUW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M1HlR2lEPTB;MUi4MlI1KG6PMnjCV2FPT0WU
COR-L105NI\6cpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NHS2XmNKSzVyPUG4PE46OiCwTR?=NEnhUlFUSU6JRWK=
HT-1376MkDGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MkLqTWM2OD1zOEmuNFEhdk1?MmTZV2FPT0WU
RPMI-8866MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MUjJR|UxRTF7Mj6xN{BvVQ>?NHzNXoxUSU6JRWK=
NCI-H2126M1vBXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MYLJR|UxRTF7Mj6yJI5OMny0V2FPT0WU
KARPAS-422MlmxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MXTJR|UxRTF7Mz60NUBvVQ>?MWnTRW5ITVJ?
COLO-741NWf1RZE{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M1K1OmlEPTB;MUm0MlU5KG6PMYHTRW5ITVJ?
IPC-298M3S4TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NVi5NFB2UUN3ME2xPVYvOjFibl2=MYHTRW5ITVJ?
OE19NFPYU5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MWXJR|UxRTJyMD6xPEBvVQ>?MXnTRW5ITVJ?
NCI-H1694M4jqPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M3vDN2lEPTB;MkCwMlI3KG6PMofpV2FPT0WU
SW1990NVztWXBVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MlS0TWM2OD1{MEGuPUBvVQ>?MUDTRW5ITVJ?
LNCaP-Clone-FGCMV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NUPTUZFpUUN3ME2yNFQvPDdibl2=NVLkfXFJW0GQR1XS
LB831-BLCMoPOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NIGxW3hKSzVyPUKwOk4zPSCwTR?=M{jFcXNCVkeHUh?=
HCT-116M3f2UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MYLJR|UxRTJyNz6zPUBvVQ>?NInMWo5USU6JRWK=
BxPC-3NXfMS4UxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M3vpXGlEPTB;MkGwMlk3KG6PMkL0V2FPT0WU
HT-1197MlvUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NWDUZ4lFUUN3ME2yNVIvPThibl2=MkXhV2FPT0WU
GB-1M2OwRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MmjCTWM2OD1{MUKuO|Mhdk1?M3\Oe3NCVkeHUh?=
RPMI-8226M3XYUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NVzUXHc{UUN3ME2yNVMvOzdibl2=MXvTRW5ITVJ?
L-540MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MU\JR|UxRTJzMz60PUBvVQ>?M3vuWHNCVkeHUh?=
NCI-H1882NHqz[2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NHPtUIpKSzVyPUKxOUBvVQ>?MUnTRW5ITVJ?
A673Ml6zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NVS5fGE1UUN3ME2yNVUvPzlibl2=NYXYfZJIW0GQR1XS
NCI-H650MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NEHZVJdKSzVyPUKxO{43OSCwTR?=NEjneVZUSU6JRWK=
KM12MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MUjJR|UxRTJzOD6xOUBvVQ>?MnXzV2FPT0WU
KP-N-YSM1za[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NWOwOJQzUUN3ME2yNVgvPCCwTR?=M4XJbXNCVkeHUh?=
COLO-684NUL6Oo81T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M3vKd2lEPTB;MkG5Mlc6KG6PMVrTRW5ITVJ?
MHH-NB-11NFezdYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MnvTTWM2OD1{MkCuNlIhdk1?NXzYUppsW0GQR1XS
HO-1-N-1M17JeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MlTOTWM2OD1{MkKuPFMhdk1?M1rCeHNCVkeHUh?=
NOMO-1MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NGWzSXpKSzVyPUKyOE41OyCwTR?=MYjTRW5ITVJ?
KYSE-70MnLhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M3\5OGlEPTB;MkK0MlY3KG6PMV\TRW5ITVJ?
NCI-H838M32zOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M3\ZT2lEPTB;MkK0Mlc{KG6PMV\TRW5ITVJ?
NYMXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NIDtbGxKSzVyPUKyPE41QSCwTR?=NV;wPXFMW0GQR1XS
NCI-H2196M2jESGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M3nCRmlEPTB;MkK5MlE2KG6PMUPTRW5ITVJ?
FTC-133M1ywR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NVHKc|hEUUN3ME2yNlkvOzdibl2=MoPPV2FPT0WU
MHH-PREB-1MnLoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NXP3VZZmUUN3ME2yNlkvQDJibl2=Mnq0V2FPT0WU
SK-MEL-2NVPSfIFlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=Mn;WTWM2OD1{M{CuN{BvVQ>?NGj0N3dUSU6JRWK=
Detroit562NH7Cc|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M4TlWGlEPTB;MkOwMlczKG6PM3r4dXNCVkeHUh?=
NCI-H2405NXT5OXg4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MoD0TWM2OD1{M{SuNUBvVQ>?MWfTRW5ITVJ?
NCI-H2081MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MknFTWM2OD1{M{SuNlchdk1?NXvqe2R1W0GQR1XS
LB2241-RCCNX7XXWhXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NW[1T5V[UUN3ME2yN|UvOTFibl2=NHf0UIpUSU6JRWK=
SNU-387MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MYnJR|UxRTJ|Nj6wPEBvVQ>?NInUR21USU6JRWK=
PC-14NHjWblJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=Ml7BTWM2OD1{M{[uNVIhdk1?NYrKZo1[W0GQR1XS
CAS-1NY\nbGVZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NWTGOlZkUUN3ME2yN|gvOzFibl2=MVnTRW5ITVJ?
TE-11NUS3SGZoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MWPJR|UxRTJ2MD64PEBvVQ>?MUHTRW5ITVJ?
LC4-1MojLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MUfJR|UxRTJ2MD64PUBvVQ>?NHjtZ2RUSU6JRWK=
HHM3nBUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NUj3dYZ3UUN3ME2yOFEvPDZibl2=NXfne3FQW0GQR1XS
JVM-2M4jPTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NHu1RoJKSzVyPUK0Nk4yPyCwTR?=MYLTRW5ITVJ?
KNS-42MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NUTySY5SUUN3ME2yOFIvPjdibl2=NGeyTJJUSU6JRWK=
T-24MorMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MVHJR|UxRTJ2NT60PEBvVQ>?NHjBe|VUSU6JRWK=
D-392MGNH7MUXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MX3JR|UxRTJ2OD61JI5ONH61eVJUSU6JRWK=
KOSC-2Ml7xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NUTMWGdwUUN3ME2yOFgvPzFibl2=MXfTRW5ITVJ?
D-283MEDM{j0fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M17RO2lEPTB;MkWwMlE{KG6PM{jtO3NCVkeHUh?=
BV-173NY\uOoFNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M3;abmlEPTB;MkWwMlc4KG6PNIDlUVdUSU6JRWK=
EW-18M123cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MljzTWM2OD1{NUCuPUBvVQ>?M2fFUXNCVkeHUh?=
MS-1M2TKRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NF7xSpNKSzVyPUK1Nk42OyCwTR?=MljvV2FPT0WU
Calu-6NYW5O21iT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MULJR|UxRTJ3Mz61OUBvVQ>?MV3TRW5ITVJ?
GR-STNHLZPVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M4LUXGlEPTB;MkW1MlQzKG6PNFnoenlUSU6JRWK=
GAKMWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M2O2[WlEPTB;MkW2MlkyKG6PNE\JcYZUSU6JRWK=
TE-9M17HNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NGDtbXVKSzVyPUK1O{41PyCwTR?=M3z3TXNCVkeHUh?=
HuH-7MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?Moi2TWM2OD1{NUiuOFQhdk1?NVjiTWdFW0GQR1XS
KYSE-520NFHGUHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MWDJR|UxRTJ4MD63O{BvVQ>?MUfTRW5ITVJ?
NCI-H520NULRdYxTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M{nBPGlEPTB;Mk[2MlYyKG6PMmLSV2FPT0WU
HD-MY-ZMnTUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NHT4XnBKSzVyPUK3Nk44QSCwTR?=M4fZNnNCVkeHUh?=
SW756Mn\DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MnnRTWM2OD1{N{SuO|ghdk1?M1HWbXNCVkeHUh?=
NB12M{\4S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7M4H4[GlEPTB;Mke3MlEzKG6PMYXTRW5ITVJ?
EW-3NHXUWGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M4jQcmlEPTB;Mke5Mlg6KG6PNVrKWFRVW0GQR1XS
AM-38MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MX;JR|UxRTJ6MT61NkBvVQ>?M1PmTnNCVkeHUh?=
NCI-H23MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NITNfXlKSzVyPUK4N{46OiCwTR?=NHnucmFUSU6JRWK=
GOTONVm0To1MT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NF22NJhKSzVyPUK4OU42PiCwTR?=M4LPSXNCVkeHUh?=
NCI-H1693M2Ho[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M4DU[GlEPTB;MkmwMlMzKG6PM4DLbHNCVkeHUh?=
MOLT-16MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MWLJR|UxRTJ7MD61JI5ONITae45USU6JRWK=
HOP-92NVLtSFR2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NGXZS|JKSzVyPUK5NE44KG6PNIjueWFUSU6JRWK=
MDA-MB-361MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NG\leIZKSzVyPUK5Nk43PSCwTR?=NVnUNXFGW0GQR1XS
Ramos-2G6-4C10NVG0cnhsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MXfJR|UxRTJ7ND61OUBvVQ>?M2L5S3NCVkeHUh?=
CAL-54NXPHO|hWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MlLmTWM2OD1|MECuO|Mhdk1?M1LUN3NCVkeHUh?=
D-263MGM1jqOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M4fFdmlEPTB;M{C1MlUzKG6PM3L4NHNCVkeHUh?=
SKG-IIIaMXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NY\FVFd2UUN3ME2zNVEvOTRibl2=NXvWUm9JW0GQR1XS
HAL-01MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NXfpeFBIUUN3ME2zNVMvPDRibl2=M4H1XHNCVkeHUh?=
LAN-6Mmn0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M2PSbWlEPTB;M{G1MlEyKG6PNW\zZZYzW0GQR1XS
NCI-H1304MlyxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MVTJR|UxRTN{MT6xO{BvVQ>?MlHkV2FPT0WU
no-11NV;HfmgxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NXPkT3ViUUN3ME2zNlEvPjRibl2=M3\reHNCVkeHUh?=
IST-MES1NIXpVWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MXvJR|UxRTN{Mz6zOUBvVQ>?NUPTUodDW0GQR1XS
L-363NG\rNmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NGT5eWVKSzVyPUOyOE41OyCwTR?=NULre5RFW0GQR1XS
EM-2NGHuPJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MknETWM2OD1|MkWuOFEhdk1?NH7Vc4FUSU6JRWK=
DV-90MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M{TCVmlEPTB;M{K5MlQ2KG6PNGPTcXpUSU6JRWK=
Saos-2MlHPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MlfHTWM2OD1|MkmuPVQhdk1?NF;kVpJUSU6JRWK=
UMC-11NYPrSpdYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MnPqTWM2OD1|M{GuNlghdk1?NISwNHZUSU6JRWK=
RajiNVHKNVlQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MorpTWM2OD1|M{SuOlQhdk1?M3ixV3NCVkeHUh?=
RXF393NEP4VGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NX7uXHVLUUN3ME2zN|UvPDNibl2=NIqxb41USU6JRWK=
EW-11NY[2enpTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M1X5VWlEPTB;M{SxMlU3KG6PNVWzZmQ2W0GQR1XS
BL-70MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NYjKXHpDUUN3ME2zOFIvODFibl2=NUnvTYxrW0GQR1XS
LB373-MEL-DMofMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MV3JR|UxRTN2ND62OEBvVQ>?MlKxV2FPT0WU
LU-139M2r3cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M3jaS2lEPTB;M{S0MlkzKG6PNVrJeY1sW0GQR1XS
U-87-MGMljES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M1jpR2lEPTB;M{S2MlA1KG6PMkG1V2FPT0WU
LU-65M{jyTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M{GyfmlEPTB;M{S2MlQhdk1?Mn3MV2FPT0WU
U031MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NXzrdXN6UUN3ME2zOVMvQDdibl2=MlTUV2FPT0WU
HNMofWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M4fhWGlEPTB;M{W0MlI4KG6PMUnTRW5ITVJ?
MHH-CAL-2Ml;kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M4\pemlEPTB;M{W5MlIyKG6PMnvjV2FPT0WU
NCI-H510AMXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M2XoSGlEPTB;M{W5MlU6KG6PMoPvV2FPT0WU
NB5M{C2cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MoHGTWM2OD1|NUmuPFEhdk1?MVPTRW5ITVJ?
KG-1NHTUNYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M{TWdmlEPTB;M{[xMlUzKG6PM1j4[3NCVkeHUh?=
EFO-21MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NFvw[HhKSzVyPUO2NU45PSCwTR?=MnrIV2FPT0WU
UACC-257M4DZd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MVTJR|UxRTN4Mj6wOUBvVQ>?NGfVXYVUSU6JRWK=
SW1417M3Xpb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7M1nxfWlEPTB;M{[zMlI{KG6PMWDTRW5ITVJ?
NCI-H1417NXzXSWp[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NUDnZWg1UUN3ME2zO|AvODRibl2=NXu0cFVVW0GQR1XS
DSH1MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MlntTWM2OD1|N{KuO|Ihdk1?MVHTRW5ITVJ?
CAKI-1MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MYXJR|UxRTN5NT60PEBvVQ>?M2rUSHNCVkeHUh?=
SIMAMlGyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NUXsTo1TUUN3ME2zPFEvQDZibl2=MUPTRW5ITVJ?
LS-1034M3:1Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NX\mNYxKUUN3ME2zPFQvPTFibl2=MVPTRW5ITVJ?
K-562M33hb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NFvsR3JKSzVyPUO4OU45KG6PNI\yb3lUSU6JRWK=
LOXIMVIMorrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NGnTN4lKSzVyPUO4PU4yQSCwTR?=MmK4V2FPT0WU
MC116M1HtTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7Mk\HTWM2OD1|OUGuOFEhdk1?NUHzN2M5W0GQR1XS
MPP-89MknTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MmrLTWM2OD1|OUKuPVQhdk1?MYTTRW5ITVJ?
SN12CNHfiS|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M1rJXGlEPTB;M{m0Mlg4KG6PM4TIN3NCVkeHUh?=
BHT-101M1TLU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NHXCWXNKSzVyPUO5OU46OiCwTR?=NEj3fm1USU6JRWK=
DMS-114NHTmPJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MUTJR|UxRTN7Nj6zNUBvVQ>?M1S3O3NCVkeHUh?=
NCI-H1838NGTwS21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MmW0TWM2OD12MEWuNFUhdk1?M4j5cnNCVkeHUh?=
HTMXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NWHrdHhzUUN3ME20NFUvOTVibl2=M{fYZXNCVkeHUh?=
Caov-3Moe1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M3zN[WlEPTB;NEC2MlE6KG6PMV3TRW5ITVJ?
LB2518-MELNV;6WFdOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MonNTWM2OD12MUOuNUBvVQ>?MoLxV2FPT0WU
C3ANHPEOmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M3XsXGlEPTB;NEG1Mlc6KG6PMnPCV2FPT0WU
NCI-H226Mo[1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?Mmr1TWM2OD12MU[uOlQhdk1?M2XFN3NCVkeHUh?=
KMS-12-PEMnfJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NX65UGp4UUN3ME20NVgvODZibl2=M{XKeXNCVkeHUh?=
RERF-LC-MSNH:yV25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NVrMN4h7UUN3ME20NlUvODVibl2=NYLDV2M1W0GQR1XS
OE33NWfVZYd3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NVvwcXVXUUN3ME20NlYvODJibl2=M1P1ZnNCVkeHUh?=
COLO-678M3HXNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NYPiSGdvUUN3ME20NlcvOThibl2=MYrTRW5ITVJ?
NCI-H1963NIPlZmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MmG5TWM2OD12M{CuNVEhdk1?NHflNIFUSU6JRWK=
LAMA-84NEfzSodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M{X5N2lEPTB;NEO3MlMhdk1?MUXTRW5ITVJ?
NCI-H2171M3znWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MV;JR|UxRTR2MD62O{BvVQ>?MonuV2FPT0WU
U-266MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NIrWdJBKSzVyPUS1NU41QSCwTR?=MlvVV2FPT0WU
SNU-C2BMnTxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M3XOe2lEPTB;NE[wMlk4KG6PMVHTRW5ITVJ?
T47DMoXMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NVTw[YdmUUN3ME20OlkvPjlibl2=NXnafmdEW0GQR1XS
TE-6Mk\WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MVPJR|UxRTR4OT64NUBvVQ>?M3LwXXNCVkeHUh?=
OVCAR-3NYDYNmp3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MVLJR|UxRTR5MD60NUBvVQ>?NWH2fWlZW0GQR1XS
C-4-IINILrVG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NYD6cY9FUUN3ME20O|IvPTZibl2=NXPPXFVqW0GQR1XS
EFM-19MnvWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?Ml2xTWM2OD12N{iuNlchdk1?MXXTRW5ITVJ?
NCI-N87NHfEUnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NF:2[IZKSzVyPUS3PU46OiCwTR?=M3nxXHNCVkeHUh?=
NCI-H187MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NVPV[pFSUUN3ME20PVMvOjFibl2=MUnTRW5ITVJ?
MDA-MB-157MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NWO2NY52UUN3ME20PVkvODFibl2=MlTzV2FPT0WU
OPM-2MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NV;6ZZM4UUN3ME21NFEvQDFibl2=M2THS3NCVkeHUh?=
COLO-320-HSRNV[4OmdDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MnPzTWM2OD13MUOuNVYhdk1?NWC1S41DW0GQR1XS
RMG-IM4O5dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MX3JR|UxRTVzMz65PEBvVQ>?MorWV2FPT0WU
IST-SL1MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MmnTTWM2OD13MUeuOFIhdk1?Mn72V2FPT0WU
UACC-893NXPG[IJsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MXfJR|UxRTV{MT61NUBvVQ>?NHj3XnlUSU6JRWK=
BeckerMl\YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M135b2lEPTB;NUKxMlg{KG6PMX\TRW5ITVJ?
HPAF-IIMXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?Mn;5TWM2OD13MkeuNlQhdk1?MYDTRW5ITVJ?
HCC1954NUHneWo4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M1njPWlEPTB;NUSwMlg{KG6PMlLBV2FPT0WU
SNU-449NGi4V2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M4WycmlEPTB;NUS4MlAyKG6PMmLwV2FPT0WU
NCI-H1563MlLnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MYTJR|UxRTV3Nj60PUBvVQ>?MXHTRW5ITVJ?
HDLM-2MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MUTJR|UxRTV4OD61PUBvVQ>?M2PBdHNCVkeHUh?=
NCI-H69M{Twemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NWLk[o5zUUN3ME21OlgvQCCwTR?=MUfTRW5ITVJ?
NCI-SNU-5M{DjPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MXvJR|UxRTV5MD6xOUBvVQ>?NUfPO4NvW0GQR1XS
NCI-H1792NV;2PIdET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=Mmn4TWM2OD13N{KuOFMhdk1?Mk\hV2FPT0WU
NCI-H2141NF\uPXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NYHXfppDUUN3ME21O|MvPjlibl2=NULzdHVxW0GQR1XS
KMOE-2NI\RVmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NYHhR45pUUN3ME21O|YvOzJibl2=M3TIdnNCVkeHUh?=
NCI-H1155NGPP[JhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M{HJcGlEPTB;NUe5Mlg4KG6PMkDPV2FPT0WU
LK-2NU\rWHBWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MlXWTWM2OD13OEGuNFchdk1?MnzWV2FPT0WU
HCC1187NIKwcFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M2PlSWlEPTB;NUmxMlQ4KG6PMVfTRW5ITVJ?
EGI-1MkDrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M3HQXmlEPTB;NUm4MlI4KG6PM1e0WHNCVkeHUh?=
NCI-H1623NET5NYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MV3JR|UxRTZyND62JI5OMmrlV2FPT0WU
MN-60MoTUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MknOTWM2OD14MEWuN|chdk1?NGP6NYVUSU6JRWK=
JARM2G4cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M{TGRWlEPTB;NkK1Mlk2KG6PNWiwU2tUW0GQR1XS
HCC1419M4nlRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NXfiZWExUUN3ME22N|EvPzRibl2=MYHTRW5ITVJ?
LU-165MmjPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NX7rcZB{UUN3ME22N|kvPCCwTR?=NYftdY9GW0GQR1XS
TYK-nuNXnNOYs5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M3PSeGlEPTB;Nk[yMlU2KG6PNX75coxDW0GQR1XS
DG-75M1nn[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7M1jkRWlEPTB;Nk[1Mlg{KG6PNGHiR|BUSU6JRWK=
PFSK-1NIXtTo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MmPyTWM2OD14N{iuNFghdk1?MkjkV2FPT0WU
MKN7MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MXnJR|UxRTZ6OT65OUBvVQ>?MkThV2FPT0WU
DMS-153M3Lzemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7Mm[2TWM2OD14OUiuNVUhdk1?NIL4U|JUSU6JRWK=
HTC-C3MmXkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NF3pe|hKSzVyPUewN{46PCCwTR?=MUfTRW5ITVJ?
GCIYNFzobWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MWfJR|UxRTd{NT6xNkBvVQ>?NHnoXpRUSU6JRWK=
NCI-H1092NFzlOGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M3O4TmlEPTB;N{O3Mlk2KG6PMVvTRW5ITVJ?
EB-3NWTsV3NpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M2npNGlEPTB;N{exMlAzKG6PMUfTRW5ITVJ?
CAL-120MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M1;CRmlEPTB;N{e3MlUzKG6PMnHGV2FPT0WU
BT-474Mon4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NX\E[FJEUUN3ME23O|gvQDFibl2=NH;1d2hUSU6JRWK=
L-428MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NF\MWllKSzVyPUe5NE46KG6PNYjjTVV5W0GQR1XS
Mo-TNXTpTmc{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NWL2WJBDUUN3ME24NFQvPjVibl2=NGLzfZJUSU6JRWK=
CAL-72M{C2Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MXPJR|UxRTh2MD62O{BvVQ>?Moj5V2FPT0WU
AsPC-1NFe4fFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NWjwdnprUUN3ME24OVUvOjZibl2=NYTMW2FZW0GQR1XS
U-118-MGNFPnZ3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MkDKTWM2OD16NU[uN|Qhdk1?NVHrc4FQW0GQR1XS
GCTNH\jT|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MWXJR|UxRTh4MT60PEBvVQ>?MU\TRW5ITVJ?
EKVXM1jZXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M1TtV2lEPTB;OEexMlg4KG6PNV3neXduW0GQR1XS
NCI-H1755MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MX;JR|UxRTh5Mz61NkBvVQ>?M4LONHNCVkeHUh?=
Capan-2M1rFSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M3zqZmlEPTB;OEm4MlEyKG6PNX7kcm5XW0GQR1XS
NCI-H1793MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M3HjfWlEPTB;OUCwMlg4KG6PMnzIV2FPT0WU
PLC-PRF-5MlP2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M2S3dWlEPTB;OUCxMlM2KG6PNVLGd2ljW0GQR1XS
M14NVHBe|dpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=Mmm0TWM2OD17MEWuNlchdk1?Mn:yV2FPT0WU
SK-MEL-24Moe3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M3nN[mlEPTB;OUG0MlM2KG6PNES3cFJUSU6JRWK=
SK-MM-2NV7vVIpJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NES1[WhKSzVyPUm0Nk4{KG6PMnv6V2FPT0WU
PC-3NHf0bG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NWf4XHlYUUN3ME25OVcvOjJibl2=MoX6V2FPT0WU
EW-24MkLUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NIDXSY1KSzVyPUm3NE41KG6PNUPLRVN1W0GQR1XS
MDA-MB-175-VIIMlrXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NYfnfVRtUUN3ME25O|EvPTNibl2=NXzsc|ZbW0GQR1XS
NCI-H1581NIi4TVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NHfYbo9KSzVyPUm4NU4{OSCwTR?=MWrTRW5ITVJ?
THP-1M13rWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MnLHTWM2OD17OEmuOFIhdk1?M1z3S3NCVkeHUh?=
NCI-H1993Mm\rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M2L1OWlEPTB;MT6wNFA4PiEQvF2=Ml7YV2FPT0WU
DOKMULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M{LNeGlEPTB;MT6wNVc3OiEQvF2=M{nZenNCVkeHUh?=
KINGS-1NVzUU5B6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MYPJR|UxRTFwMEG5JO69VQ>?MWjTRW5ITVJ?
YTM4jSNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MkP1TWM2OD1zLkC0OVY5KM7:TR?=NHzMZZFUSU6JRWK=
TGBC1TKBM2jxbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M4XRSGlEPTB;MT6wOlA{PiEQvF2=MWjTRW5ITVJ?
TCCSUPNX3DXZh{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NIS1ZpZKSzVyPUGuNlMxQDNizszNM4TYcXNCVkeHUh?=
BENNGPDblVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MVLJR|UxRTFwMkO3OFIh|ryPMmjVV2FPT0WU
KARPAS-45M3e4eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MWnJR|UxRTFwMk[3OlMh|ryPMUPTRW5ITVJ?
COLO-829MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NWDsbJpnUUN3ME2xMlI4PDhizszNMUnTRW5ITVJ?
UACC-62NEfP[XJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NHLyNZlKSzVyPUGuN|IyPDVizszNNVrMSVF{W0GQR1XS
NCI-H446MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NIXKXZFKSzVyPUGuN|M4PzFizszNMn7oV2FPT0WU
RO82-W-1NWL5OGxXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MmLTTWM2OD1zLkO0N|M4KM7:TR?=MWfTRW5ITVJ?
NCI-H2452Mkn1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NEi4N5pKSzVyPUGuN|cyOjlizszNMVvTRW5ITVJ?
RLMorqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MVnJR|UxRTFwNEKwOlYh|ryPMoPaV2FPT0WU
NCI-H1522M3vZ[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MWPJR|UxRTFwNEOxOVkh|ryPM4TTWHNCVkeHUh?=
TGWMmXDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?Mn;BTWM2OD1zLkS1PVQzKM7:TR?=NXrodWtuW0GQR1XS
HT55MoXSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NIrYPJBKSzVyPUGuOFcyPjhizszNM{HvVnNCVkeHUh?=
KARPAS-299MnPXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?Mn;rTWM2OD1zLkS3PFQyKM7:TR?=NV:5XFRqW0GQR1XS
KY821MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MonhTWM2OD1zLkS5OFI6KM7:TR?=NXjGfpVpW0GQR1XS
MDA-MB-231NXPHPHRDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M1LJ[GlEPTB;MT61N|A2PSEQvF2=NI\xTWdUSU6JRWK=
NCI-H82Mn3XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MX;JR|UxRTFwNUewNlYh|ryPMn7DV2FPT0WU
MDA-MB-134-VIM3jPZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M1u5[mlEPTB;MT62NVcyOSEQvF2=MoLkV2FPT0WU
PANC-08-13NHHwNWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MV;JR|UxRTFwNkOwPFQh|ryPNFX1XHBUSU6JRWK=
D-542MGNVLkUpBPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M{W4bWlEPTB;MT62OVMxPSEQvF2=NULXe2NZW0GQR1XS
LC-1FMVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NFrnb3ZKSzVyPUGuOlYzODNizszNMV;TRW5ITVJ?
KP-N-YNMYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M3[xVWlEPTB;MT62OlM1OyEQvF2=NYPZd|NvW0GQR1XS
MFE-280NYX1NI5sT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NH:2fYdKSzVyPUGuOlY5OTJizszNM{jCRnNCVkeHUh?=
S-117Mk\mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MlvRTWM2OD1zLkewOVA1KM7:TR?=MX7TRW5ITVJ?
NCI-H1573M1e5emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NWTWSpFFUUN3ME2xMlcyPzN|IN88US=>MkLlV2FPT0WU
BT-20MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MoHyTWM2OD1zLke0NFY5KM7:TR?=NUKyZ5dyW0GQR1XS
NCI-H28M3OwbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NVjncXRKUUN3ME2xMlc1ODd6IN88US=>M{jzd3NCVkeHUh?=
CaR-1NE\iWYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MXjJR|UxRTFwN{izNlQh|ryPNU\2e3dJW0GQR1XS
LN-405MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MUfJR|UxRTFwOECxOFMh|ryPNH\MZm1USU6JRWK=
RT4MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MY\JR|UxRTFwOES0NVch|ryPNHTi[opUSU6JRWK=
NCI-H889MoL0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NFnSTVhKSzVyPUGuPVM5QDZizszNNVTV[mN6W0GQR1XS
SW1463M4nRUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MUfJR|UxRTFwOUW3NFEh|ryPM3vqU3NCVkeHUh?=
SCLC-21HM2TEbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M4HJN2lEPTB;Mj6wNFYzPCEQvF2=MXjTRW5ITVJ?
CP66-MELNV\Q[HBsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M4fsfWlEPTB;Mj6wNVc3PyEQvF2=NXvVNYI1W0GQR1XS
Hs-578-TNGjZdXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NIHpfWVKSzVyPUKuNFE4QDJizszNNY\GOphSW0GQR1XS
HCC70NHrsUHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MUPJR|UxRTJwMEW0OlMh|ryPM163S3NCVkeHUh?=
SW1088NWfVbItiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MnvjTWM2OD1{LkC2PVMyKM7:TR?=NUTUWpJrW0GQR1XS
NB6NVPNWYlDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NIHjUVRKSzVyPUKuNVg2KM7:TR?=NV7q[lV6W0GQR1XS
KU-19-19NVHEd|ZoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NUXQdo17UUN3ME2yMlI3QTF5IN88US=>MXHTRW5ITVJ?
A704MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MoX5TWM2OD1{LkK5NVM2KM7:TR?=NVrOUFBMW0GQR1XS
EVSA-TNGm2RlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M{HQb2lEPTB;Mj6zNFA5QSEQvF2=MljTV2FPT0WU
HCT-15NHXpV3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MUHJR|UxRTJwM{W0OlYh|ryPMkTtV2FPT0WU
HuO-3N1MlzRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NF:0WYhKSzVyPUKuN|Y2QDNizszNNH3Se2hUSU6JRWK=
GMS-10NF72V2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M2LYbGlEPTB;Mj6zPVc{QCEQvF2=M1TVNnNCVkeHUh?=
TGBC24TKBNEm1[npIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NGHkbVdKSzVyPUKuOFE1OjlizszNNYTIelA1W0GQR1XS
C2BBe1NFq5[GxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M1nSUmlEPTB;Mj61NVMzQCEQvF2=MY\TRW5ITVJ?
SK-N-DZMnLLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?Mk\ITWM2OD1{LkW2OVkzKM7:TR?=MXnTRW5ITVJ?
SK-N-ASM3;N[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M4HZcWlEPTB;Mj63N|AyPSEQvF2=MVHTRW5ITVJ?
T98GNVX6RlduT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MVnJR|UxRTJwOEC0NFEh|ryPMl;TV2FPT0WU
DMS-79MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MXfJR|UxRTJwOUC5PFgh|ryPMnmyV2FPT0WU
SNU-475Mn7tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MUnJR|UxRTJwOUK1O|Ih|ryPNEfjWG5USU6JRWK=
COLO-792MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MkfBTWM2OD1|LkCyPFch|ryPNEnXdo1USU6JRWK=
YAPCNIixWYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NF25dnBKSzVyPUOuN|I5OzJizszNMXfTRW5ITVJ?
UACC-812NIjMS3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MoHtTWM2OD1|LkOzO|M5KM7:TR?=NH\aPIpUSU6JRWK=
MewoNUPEW4lRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NVP2dFkxUUN3ME2zMlQ3ODh4IN88US=>NG[3[HZUSU6JRWK=
COLO-824MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MnnpTWM2OD1|LkW3N|c5KM7:TR?=MlXnV2FPT0WU
SCC-9NVjufmtKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M4G4XGlEPTB;Mz65NVMxQSEQvF2=NH\oclFUSU6JRWK=
CP50-MEL-BNXHKbJlYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MnL4TWM2OD1|Lkm4O|A{KM7:TR?=MkX2V2FPT0WU
NCI-H345MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NHqyPFdKSzVyPUSuNFEyPzRizszNM4\MVHNCVkeHUh?=
COR-L88NILiZlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MonXTWM2OD12LkO5OVgh|ryPMVHTRW5ITVJ?
RCM-1NXzMNIt{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NVzaPWxPUUN3ME20MlQ6Ojd{IN88US=>MmXRV2FPT0WU
JVM-3NXz3UIJQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MWXJR|UxRTRwNkC2NVgh|ryPMUnTRW5ITVJ?
ECC4NYf2WYczT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M{\WSWlEPTB;ND63OlU1OSEQvF2=MYjTRW5ITVJ?
MDA-MB-453NWDPTFVRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MXnJR|UxRTRwOEWxN|Qh|ryPNX65WYhWW0GQR1XS
SK-N-FIMWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NHH6O4VKSzVyPUWuNlI5PzdizszNMV7TRW5ITVJ?
D-502MGM2XUR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NHPXVIRKSzVyPUWuNlQzPjJizszNM{HlfnNCVkeHUh?=
NCI-H2227NELYRldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NEP3Z5pKSzVyPUWuN|YzOzFizszNNFPCbm9USU6JRWK=
DMS-53MmHZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NIDLdINKSzVyPU[uNVcyODZizszNM3fyUXNCVkeHUh?=
LB771-HNCNW\MNVkyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MWLJR|UxRTZwNE[4NFYh|ryPM4f2WHNCVkeHUh?=
BB49-HNCNGD3NFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M17XXWlEPTB;Nz60NVc6OSEQvF2=Mo\1V2FPT0WU
MDA-MB-415NUHSUFdoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MlnsTWM2OD15LkW3N|A{KM7:TR?=NVXSSld{W0GQR1XS
TALL-1NVS3fJd5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=Mm\aTWM2OD15Lkm2PFgh|ryPMWLTRW5ITVJ?
HCC1395NH\NOGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MnTkTWM2OD16LkG1NVIzKM7:TR?=M1fyR3NCVkeHUh?=
EFE-184MlK4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NGi4[HJKSzVyPUiuN|czOTZizszNMkXrV2FPT0WU
EC-GI-10M1H0SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NWGy[2tCUUN3ME24MlY5Pjh4IN88US=>M2q4W3NCVkeHUh?=
TTMmLlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NGXKO3JKSzVyPUmuNFY6PjZizszNMWjTRW5ITVJ?
U-2-OSNWDP[WhJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NG\Nc2tKSzVyPUmuPFE{QTNizszNMl7vV2FPT0WU
SHP-77MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NGrIeYVKSzVyPUmuPVAzQSEQvF2=Ml;JV2FPT0WU
HCC1143NGHTR2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NWOzfGljUUN3ME2xNE41Pzl5IN88US=>NXThTWRXW0GQR1XS
A498NFTVflJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MlHsTWM2OD1zOD6yPVc3KM7:TR?=Ml;lV2FPT0WU
LS-513M1v0V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NF3LSHVKSzVyPUG4MlYxQTNizszNMWPTRW5ITVJ?
K052MlzwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NH\Md3JKSzVyPUKxMlQ1OThizszNMmnvV2FPT0WU
SiHaNFnWdmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NIDJV3FKSzVyPUKzMlM{PzFizszNNWrq[GZSW0GQR1XS
RCC10RGBNVn6VohFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MlqxTWM2OD1|MD6wOlEyKM7:TR?=M3ewVnNCVkeHUh?=
NCI-SNU-16M3TuNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MlnSTWM2OD1|MT6xPFM3KM7:TR?=NHXaUWlUSU6JRWK=
SNU-C1NUnkPXRbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NWXwe3ZZUUN3ME2zNk41OTd3IN88US=>NWrwT45JW0GQR1XS
C32NGTEVJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MoLBTWM2OD1|Mj64O|Ih|ryPMVrTRW5ITVJ?
SW684NGLJNIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M2jnTGlEPTB;M{SuNVU3OSEQvF2=NHzicHhUSU6JRWK=
SK-MEL-28MlS4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NV3HclR6UUN3ME2zOU42Ozd5IN88US=>MV7TRW5ITVJ?
SK-MEL-1M1XreGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NX21cI92UUN3ME2zOk44PTR5IN88US=>M{LZTHNCVkeHUh?=
NCI-H720MoPKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MXvJR|UxRTRzLkm3NlYh|ryPMkDEV2FPT0WU
P31-FUJNEO1OXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NGLp[ZRKSzVyPUS0MlMzQDRizszNMmCwV2FPT0WU
NCI-H524NV3kcYFxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MnzwTWM2OD12OD64NlQ5KM7:TR?=MkTMV2FPT0WU

... Click to View More Cell Line Experimental Data

In vivo In vivo, Doxorubicin in combination with adenoviral MnSOD (AdMnSOD) plus 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) has the greatest effect in decreasing the volumes of MB231 tumors and prolonging survival of mice. [1] Although its use is limited by the chronic and acute toxic side effects it produces, Doxorubicin is essential in treating breast and oesophageal carcinomas, solid tumours in childhood, osteosarcomas, Kaposi's sarcoma, soft tissue sarcomas, and Hodgkin and non-Hodgkin lymphomas. [2]
Features

Protocol(Only for Reference)

Animal Study: [1]

Animal Models Female athymic nude mice injected s.c. with MB231 cells
Formulation Dissolved in DMSO, and diluted in saline
Dosages 3 mg/kg/day
Administration Delivered intratumorly

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDog
Weight (kg)0.020.151.80.40.0810
Body Surface Area (m2)0.0070.0250.150.050.020.5
Km factor36128520
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

References

[1] Sun W, et al. Cancer Res, 2009, 69(10), 4294-4300.

[2] Granados-Principal S, et al. Food Chem Toxicol, 2010, 48(6), 1425-1438.

view more

Clinical Trial Information( data from http://clinicaltrials.gov, updated on 2016-05-07)

NCT Number Recruitment Conditions Sponsor
/Collaborators
Start Date Phases
NCT02743065 Not yet recruiting Hepatocellular Carcinoma Fifth Affiliated Hospital, Sun Yat-Sen University|Third A  ...more Fifth Affiliated Hospital, Sun Yat-Sen University|Third Affiliated Hospital, Sun Yat-Sen University September 2016 --
NCT02685657 Not yet recruiting Triple Negative Breast Cancer Russian Academy of Medical Sciences|Russian Society of Cl  ...more Russian Academy of Medical Sciences|Russian Society of Clinical Oncology September 2016 Phase 2
NCT02538926 Not yet recruiting B Acute Lymphoblastic Leukemia|B Lymphoblastic Lymphoma|Recurrent Adult Acute Lymphoblastic Leukemia|Recurrent B Lymphoblastic Lymphoma|Recurrent T  ...more B Acute Lymphoblastic Leukemia|B Lymphoblastic Lymphoma|Recurrent Adult Acute Lymphoblastic Leukemia|Recurrent B Lymphoblastic Lymphoma|Recurrent T Lymphoblastic Leukemia/Lymphoma|Refractory B Lymphoblastic Lymphoma|Refractory T Lymphoblastic Lymphoma|T Acute Lymphoblastic Leukemia|T Lymphoblastic Lymphoma University of Washington|National Cancer Institute (NCI) August 2016 Phase 2
NCT02723994 Not yet recruiting B-cell Acute Lymphoblastic Leukemia Incyte Corporation|Childrens Oncology Group August 2016 Phase 2
NCT02732015 Not yet recruiting Sarcoma M.D. Anderson Cancer Center|Tesaro, Inc. July 2016 Phase 2

view more

Chemical Information

Download Doxorubicin (Adriamycin) SDF
Molecular Weight (MW) 579.98
Formula

C27H29NO11.HCl

CAS No. 25316-40-9
Storage 3 years -20℃powder
6 months-80℃in solvent
Synonyms NSC 123127
Solubility (25°C) * In vitro DMSO 100 mg/mL warmed (172.41 mM)
Water 20 mg/mL (34.48 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Name (8S,10S)-10-((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyl-tetrahydro-2H-pyran-2-yloxy)-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione hydrochloride

Customer Product Validation (6)


Click to enlarge
Rating
Source Sci Transl Med, 2015, 7(284): 284ra57 . Doxorubicin (Adriamycin) purchased from Selleck
Method Apoptotic Response Assay
Cell Lines MDA-MB-231 cells
Concentrations 10 mg/kg
Incubation Time 24 h
Results The apoptotic response inMDA-MB-231 (human triple-negative breast) tumors, as tested by the device, was significantly elevated to 17.5% from 7.4%by the addition of lapatinib to doxorubicin in reservoirs.

Click to enlarge
Rating
Source Cancer Res 2014 74, 298-308. Doxorubicin (Adriamycin) purchased from Selleck
Method MTT assay
Cell Lines H1299, A549, Hep3B, HT1080, HCT116, MCF7
Concentrations
Incubation Time 48 h
Results Hypoxic (1% O2 ) conditions for 48 hours. The IC50 value for cisplatin or doxorubicin significantly increased under hypoxia in H1299, A549, Hep3B, and HT1080, but did not in HCT116 and MCF7

Click to enlarge
Rating
Source J Biomed Mater Res Part A 2012 10.1002/jbm.a.34064. Doxorubicin (Adriamycin) purchased from Selleck
Method Release experiment
Cell Lines N.A.
Concentrations 0.25mg/mL
Incubation Time 2-10 h
Results Doxorubicin was loaded by equilibrium partitioning in the following manner: a stock solution of doxorubicin was prepared in 2 wt % DMSO in 1 PBS (pH 7.4) at a concentration of 0.25 mg/mL. A 5 mg/mL concentration of crushed particles (75–150 um) of P(MAA-g-EG) or P(MAA-g-EG) containing PMMA nanoparticles to doxorubicin stock solution was allowed to stir slowly for 2 h.

Click to enlarge
Rating
Source PLoS One 2014 9, e94309. Doxorubicin (Adriamycin) purchased from Selleck
Method Flow Cytometry Analysis
Cell Lines K-562, DL cells
Concentrations 5.85 uM
Incubation Time 24 h
Results It was extended our observation of DOX-uptake at microscopic level for visualizing the presence of significantly higher DOX concentration intracellularly in K-562 and DL. As observed in I and J, the intracellular level of DOX is significantly higher in cells treated with DOX-PCL63-b-PNVP90 compared to free DOX suggesting high drug delivery efficiency of the compound.

Click to enlarge
Rating
Source PLoS One 2013 8(1), e54595. Doxorubicin (Adriamycin) purchased from Selleck
Method MTT assay
Cell Lines Huh7, THLE2, Hep5B cells
Concentrations 0.016-52 uM
Incubation Time 74 h
Results Cytotoxicity by doxorubicin was measured by MTT assay atvarying concentrations on the HCC lines Huh7, THLE2, Hep3B.

Click to enlarge
Rating
Source 2014 Dr Milica Pesic from Institute for Biological Research. Doxorubicin (Adriamycin) purchased from Selleck
Method Transwell membranes assembled
Cell Lines COR-L23, RH460 cells
Concentrations 50 nM, 1 uM
Incubation Time 24 h
Results Evaluation of DOX effect on cancer cell invasion in combination with inhibitors of CXCR4 receptor (WZ811) and focal adhesion kinase (FAK; PF-573228). Two DOX resistant non-small cell lung carcinoma (NSCLC) cell lines were employed: COR-L23 that shows intrinsic resistance to DOX and RH460 with classical acquired multidrug resistant phenotype. The results show that DOX, classical cytotoxic drug, potentates known anti-migratory effects of CXCR4 receptor inhibitor (WZ811) and FAK inhibitor (PF-573228) in both types of resistant NSCLC cell lines. WZ811 had more pronounced and significant effect with DOX in RH460 cells while PF-573228 was more effective with DOX oin COR-L23 cell line.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

* Indicates a Required Field

Related Topoisomerase Products

  • SCR7

    SCR7 is a specific DNA Ligase IV inhibitor, which blocks nonhomologous end-joining (NHEJ).

  • Blasticidin S HCl

    Blasticidin S HCl is a nucleoside antibiotic isolated from Stretomyces girseochromogenes, and acts as a DNA and protein synthesis inhibitor, used to select transfected cells carrying bsr or BSD resistance genes.

  • LMK-235

    LMK-235 is a selective inhibitor of HDAC4 and HDAC5 with IC50 of 11.9 nM and 4.2 nM, respectively.

  • Etoposide

    Etoposide is a semisynthetic derivative of podophyllotoxin, which inhibits DNA synthesis via topoisomerase II inhibition activity.

  • Irinotecan

    Irinotecan is a topoisomerase I inhibitor for LoVo cells and HT-29 cells with IC50 of 15.8 μM and 5.17 μM, respectively.

    Features:Irinotecan is a prodrug that is used to treat metastatic colorectal cancer.

  • Camptothecin

    Camptothecin is a specific inhibitor of DNA topoisomerase I (Topo I) with IC50 of 0.68 μM in a cell-free assay. Phase 2.

  • Daunorubicin HCl

    Daunorubicin HCl inhibits both DNA and RNA synthesis and inhibits DNA synthesis with Ki of 0.02 μM in a cell-free assay.

  • SN-38

    SN-38 is an active metabolite of CPT-11, inhibits DNA topoisomerase I, DNA synthesis and causes frequent DNA single-strand breaks.

  • Topotecan HCl

    Topotecan HCl is a topoisomerase I inhibitor for MCF-7 Luc cells and DU-145 Luc cells with IC50 of 13 nM and 2 nM in cell-free assays, respectively.

    Features:Topotecan is a water-soluble derivative of camptothecin.

  • Idarubicin HCl

    Idarubicin HCl is a hydrochloride salt form of Idarubicin which is an anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells with IC50 of 3.3 ng/mL in a cell-free assay.

    Features:Idarubicin is a substrate for CYP450 2D6 and 2C9.

Recently Viewed Items

Tags: buy Doxorubicin (Adriamycin) | Doxorubicin (Adriamycin) ic50 | Doxorubicin (Adriamycin) price | Doxorubicin (Adriamycin) cost | Doxorubicin (Adriamycin) solubility dmso | Doxorubicin (Adriamycin) purchase | Doxorubicin (Adriamycin) manufacturer | Doxorubicin (Adriamycin) research buy | Doxorubicin (Adriamycin) order | Doxorubicin (Adriamycin) mouse | Doxorubicin (Adriamycin) chemical structure | Doxorubicin (Adriamycin) mw | Doxorubicin (Adriamycin) molecular weight | Doxorubicin (Adriamycin) datasheet | Doxorubicin (Adriamycin) supplier | Doxorubicin (Adriamycin) in vitro | Doxorubicin (Adriamycin) cell line | Doxorubicin (Adriamycin) concentration | Doxorubicin (Adriamycin) nmr
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Contact Us