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Topotecan HCl Chemical Structure
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Biological Activity
Topotecan Hydrochloride is a topoisomerase I inhibitor with an IC50 of 13 and 2 nM for MCF-7 Luc cells and DU-145 Luc cells. Topotecan hydrochloride (Hycamtin) is a chemotherapy agent that is a topoisomerase I inhibitor. It is the water-soluble derivative of camptothecin. It is used to treat ovarian cancer and lung cancer, as well as other cancer types. In vivo imaging experiments were performed using athymic nude mice inoculated i.p. with 5 ˟ 106 MCF-7 cells or s.c. with 5 ˟ 106 DU-145 cells and then treated with topotecan at 2.5 mg/kg body weight. Tumor progression and regression were monitored for 27 days. Animals inoculated s.c. with DU-145 Luc cells and then treated with topotecan demonstrated significant tumor growth and regression as measured with calipers and luminescent imaging. High correlation was observed between caliper and imaging results. [1][2]
Chemical Information
| Molecular Weight (WM): | 457.91 |
|---|---|
| Formula: | C23H23N3O5.HCl |
| CAS No.: | 119413-54-6 |
| Synonyms: |
Hycamtin, NSC 609699
|
| Dissolve in (25°C): | DMSO ≥92mg/mL |
| Water ≥92mg/mL | |
| Ethanol <1mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
Quality Control & MSDS
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