Voreloxin (SNS-595) hydrochloride
Catalog No.S7518 Synonyms: Vosaroxin
Molecular Weight(MW): 437.9
Voreloxin is a potent Topoisomerase II inhibitor with broad-spectrum anti-tumor activity. Phase 2.
Purity & Quality Control
Choose Selective Topoisomerase Inhibitors
|Description||Voreloxin is a potent Topoisomerase II inhibitor with broad-spectrum anti-tumor activity. Phase 2.|
Voreloxin exhibits potent inhibitory effect in topoisomerase II relaxation with IC50 of 3.2 μg /mL without effect on topoisomerase II cleavage. Voreloxin has a cytotoxic activity against human tumor cell lines more potent than that of etoposide.  Voreloxin has broad anti-proliferative activity in 15 cell lines, including 4 drug-resistant lines, with IC50 ranging from 0.04 to 1.155 μM. 
|In vivo||Voreloxin (50 mg/kg i.p.) shows potent in vivo antitumor activity mice implanted with P388 leukemia cells.  Voreloxin (25 mg/kg i.v.) demonstrates strong tumor growth inhibition in 10 of 11 solid tumor (breast, ovarian, colon, lung, gastric, and melanoma) xenograft models, 2 hematologic tumor xenograft models, 3 multidrug resistant tumor models and 3 murine syngeneic tumor models (Colon 26, Lewis Lung carcinoma, M5076 Ovarian Sarcoma). |
|In vitro||DMSO||1 mg/mL (2.28 mM)|
|Water||1 mg/mL (2.28 mM)|
* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
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Clinical Trial Information
|NCT Number||Recruitment||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT02658487||Recruiting||Acute Myeloid Leukemia|Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome|Acute Myeloid Leukemia With Multilineage Dysplasia|Myeloid Sarcoma|Secondary Acute Myeloid Leukemia|Therapy-Related Acute Myeloid Leukemia|Therapy-Related Myelodysplastic Syndrome||Vanderbilt-Ingram Cancer Center|National Cancer Institute (NCI)||March 2016||Phase 2|
|NCT02485353||Suspended||Leukemia, Myeloid, Acute||Hamid Sayar|Indiana University||October 2015||--|
|NCT01913951||Active, not recruiting||Myelodysplastic Syndromes||Washington University School of Medicine||November 2013||Phase 1|
|NCT01980056||Recruiting||Myelodysplastic Syndrome||Weill Medical College of Cornell University|Sunesis Pharmaceuticals||October 2013||Phase 1|Phase 2|
|NCT01191801||Unknown status||Leukemia|Acute Myeloid Leukemia|Acute Nonlymphocytic Leukemia||Sunesis Pharmaceuticals||October 2010||Phase 3|
|NCT00607997||Completed||Leukemia|Acute Disease|Acute Myeloid Leukemia|Nonlymphocytic Leukemia|Myelodysplastic Syndromes||Sunesis Pharmaceuticals||April 2008||Phase 2|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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