Voreloxin (SNS-595) hydrochloride
Catalog No.S7518 Synonyms: Vosaroxin
Molecular Weight(MW): 437.9
Voreloxin is a potent Topoisomerase II inhibitor with broad-spectrum anti-tumor activity. Phase 2.
Purity & Quality Control
Choose Selective Topoisomerase Inhibitors
|Description||Voreloxin is a potent Topoisomerase II inhibitor with broad-spectrum anti-tumor activity. Phase 2.|
Voreloxin exhibits potent inhibitory effect in topoisomerase II relaxation with IC50 of 3.2 μg /mL without effect on topoisomerase II cleavage. Voreloxin has a cytotoxic activity against human tumor cell lines more potent than that of etoposide.  Voreloxin has broad anti-proliferative activity in 15 cell lines, including 4 drug-resistant lines, with IC50 ranging from 0.04 to 1.155 μM. 
|In vivo||Voreloxin (50 mg/kg i.p.) shows potent in vivo antitumor activity mice implanted with P388 leukemia cells.  Voreloxin (25 mg/kg i.v.) demonstrates strong tumor growth inhibition in 10 of 11 solid tumor (breast, ovarian, colon, lung, gastric, and melanoma) xenograft models, 2 hematologic tumor xenograft models, 3 multidrug resistant tumor models and 3 murine syngeneic tumor models (Colon 26, Lewis Lung carcinoma, M5076 Ovarian Sarcoma). |
|In vitro||DMSO||1 mg/mL (2.28 mM)|
|Water||1 mg/mL (2.28 mM)|
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Clinical Trial Information
|NCT Number||Recruitment||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT02658487||Recruiting||Acute Myeloid Leukemia|Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome|Acute Myeloid Leukemia With Multilineage Dysplasia|Myeloid Sarcoma|Secondary Acute Myeloid Leukemia|Therapy-Related Acute Myeloid Leukemia|Therapy-Related Myelodysplastic Syndrome||Vanderbilt-Ingram Cancer Center|National Cancer Institute (NCI)||March 2016||Phase 2|
|NCT02485353||Suspended||Leukemia, Myeloid, Acute||Hamid Sayar|Indiana University||October 2015||--|
|NCT01913951||Active, not recruiting||Myelodysplastic Syndromes||Washington University School of Medicine||November 2013||Phase 1|
|NCT01980056||Recruiting||Myelodysplastic Syndrome||Weill Medical College of Cornell University|Sunesis Pharmaceuticals||October 2013||Phase 1|Phase 2|
|NCT01191801||Unknown status||Leukemia|Acute Myeloid Leukemia|Acute Nonlymphocytic Leukemia||Sunesis Pharmaceuticals||October 2010||Phase 3|
|NCT00607997||Completed||Leukemia|Acute Disease|Acute Myeloid Leukemia|Nonlymphocytic Leukemia|Myelodysplastic Syndromes||Sunesis Pharmaceuticals||April 2008||Phase 2|
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