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Sirtuin activators/inhibitors

Other DNA Damage/DNA Repair Related Inhibitors

HDAC PARP WRN Topoisomerase Telomerase DNA/RNA Synthesis MTH1 DNA alkylator High-mobility Group CRISPR/Cas9

Isoform-selective Products

SIRT1 SIRT2 SIRT3 SIRT6 SIRT5

Cat.No.	Product Name	Information	Product Use Citations	Product Validations
S1129	SRT1720 HCl	SRT1720 HCl is a selective SIRT1 activator with EC50 of 0.16 μM in a cell-free assay, but is >230-fold less potent for SIRT2 and SIRT3. SRT1720 induces autophagy.	J Cachexia Sarcopenia Muscle, 2025, 16(2):e13771 Free Radic Biol Med, 2025, 236:98-115 Cell Biol Toxicol, 2025, 41(1):24
S1899	Nicotinamide (Niacinamide)	Nicotinamide, a water-soluble vitamin, is an active component of coenzymes NAD and NADP, and also act as an inhibitor of sirtuins.	EMBO J, 2025, 44(9):2514-2540 Cell Death Dis, 2025, 16(1):160 Cell Signal, 2025, 127:111587
S2935	Nicotinamide Riboside Chloride	Nicotinamide Riboside Chloride is the chloride salt form of nicotinamide riboside(NR).NR is a new form pyridine-nucleoside of vitamin B3 that functions as a precursor to nicotinamide adenine dinucleotide(NAD) or NAD⁺ . Nicotinamide riboside chloride is a crystal form of Nicotinamide riboside (NR) chloride. Nicotinamide riboside chloride increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-induced metabolic abnormalities. Nicotinamide riboside chloride is used in dietary supplements.	bioRxiv, 2025, 2025.07.10.663928 bioRxiv, 2025, 2025.01.06.631511 Front Physiol, 2023, 14:1164287
S1396	Resveratrol (trans-Resveratrol)	Resveratrol has a wide spectrum of targets including cyclooxygenases(i.e. COX, IC50=1.1 μM), lipooxygenases（LOX, IC50=2.7 μM）, kinases, sirtuins and other proteins. It has anti-cancer, anti-inflammatory, blood-sugar-lowering and other beneficial cardiovascular effects. Resveratrol induces mitophagy/autophagy and autophagy-dependent apoptosis.	Aging Cell, 2025, e70075 Biomed Pharmacother, 2025, 190:118393 Breast Cancer Res, 2025, 27(1):186
S2391	Quercetin (Sophoretin)	Quercetin, a natural flavonoid present in vegetables, fruit and wine, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4-5.4 μM. Quercetin induces mitophagy, apoptosis and protective autophagy. Phase 4.	Alzheimers Res Ther, 2025, 17(1):176 Cell Mol Life Sci, 2025, 82(1):164 Virol Sin, 2025, S1995-820X(25)00102-6
S1541	Selisistat (EX-527)	Selisistat (EX 527, SEN0014196) is a potent and selective SIRT1 inhibitor with IC50 of 38 nM in a cell-free assay, exhibits >200-fold selectivity against SIRT2 and SIRT3. Phase 2.	Adv Sci (Weinh), 2025, 12(5):e2409516 Cell Death Dis, 2025, 16(1):548 Elife, 2025, 13RP100406
S2804	Sirtinol	Sirtinol is a specific SIRT1 and SIRT2 inhibitor with IC50 of 131 μM and 38 μM in cell-free assays, respectively.	Drug Des Devel Ther, 2023, 17:563-577 Shock, 2023, 60(1):75-83 Surg Open Sci, 2023, 12:35-42
S8628	3-TYP	3-TYP (3-(1H-1,2,3-triazol-4-yl) pyridine) is a selective SIRT3 inhibitor which is selective for Sirt3 over Sirt1 and Sirt2. The IC50 values for SITR1, SIRT2, SIRT3 are 88 nM, 92 nM, 16 nM respectively.	Cell Death Dis, 2025, 16(1):160 Mol Med Rep, 2025, 31(5)122 Cell Rep, 2024, 43(9):114728
S7577	AGK2	AGK2 is a potent, and selective SIRT2 inhibitor with IC50 of 3.5 μM that minimally affects either SIRT1 or SIRT3 at 10-fold higher levels.	Cell Mol Life Sci, 2025, 82(1):45 Aging Cell, 2025, e70075 Cell Mol Gastroenterol Hepatol, 2025, 19(7):101494
S8627	OSS_128167	OSS_128167 (SIRT6-IN-1) is a specific SIRT6 inhibitor with IC50 values of 89, 1578 and 751 μM for SIRT6, SIRT1 and SIRT2, respectively. This compound has anti-viral effect in HBV transcription and replication.	Front Immunol, 2024, 15:1402834 Sci Rep, 2024, 14(1):30924 Antioxidants (Basel), 2023, 12(3)714

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