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Sirtuin Inhibitors
| Cat.No. | Product Name | Information | Product Use Citations | Product Validations |
|---|---|---|---|---|
| S1541 | Selisistat (EX-527) | Selisistat (EX 527, SEN0014196) is a potent and selective SIRT1 inhibitor with IC50 of 38 nM in a cell-free assay, exhibits >200-fold selectivity against SIRT2 and SIRT3. Phase 2. |
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| S1899 | Nicotinamide (Niacinamide) | Nicotinamide, a water-soluble vitamin, is an active component of coenzymes NAD and NADP, and also act as an inhibitor of sirtuins. |
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| S2804 | Sirtinol | Sirtinol is a specific SIRT1 and SIRT2 inhibitor with IC50 of 131 μM and 38 μM in cell-free assays, respectively. |
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| S8628 | 3-TYP | 3-TYP (3-(1H-1,2,3-triazol-4-yl) pyridine) is a selective SIRT3 inhibitor which is selective for Sirt3 over Sirt1 and Sirt2. The IC50 values for SITR1, SIRT2, SIRT3 are 88 nM, 92 nM, 16 nM respectively. |
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| S7577 | AGK2 | AGK2 is a potent, and selective SIRT2 inhibitor with IC50 of 3.5 μM that minimally affects either SIRT1 or SIRT3 at 10-fold higher levels. |
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| S8627 | OSS_128167 | OSS_128167 (SIRT6-IN-1) is a specific SIRT6 inhibitor with IC50 values of 89, 1578 and 751 μM for SIRT6, SIRT1 and SIRT2, respectively. This compound has anti-viral effect in HBV transcription and replication. |
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| S7845 | SirReal2 | SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM. |
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| S8245 | Thiomyristoyl | Thiomyristoyl (TM) is a potent and specific SIRT2 inhibitor with an IC50 of 28 nM. It inhibits SIRT1 with an IC50 value of 98 μM and does not inhibit SIRT3 even at 200 μM. |
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| S9903 | NRD167 |
NRD167 is a potent and selective SIRT5 inhibitor. |
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| S8460 | Salermide | Salermide is a reverse amide with a strong in vitro inhibitory effect on Sirt1 and Sirt2. Compared with Sirt1, this compound is even more efficient at inhibiting Sirt2. |
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| S5914 | AK 7 | AK 7 is a brain-permeable selective SIRT2 inhibitor with an IC50 of 15.5 μM. |
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| S6744 | Inauhzin | Inauhzin is a cell-permeable SIRT1 inhibitor with an IC50 of 0.7-2 μM and reactivates p53 by inhibiting SIRT1 deacetylation activity. |
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| E1150 | SIRT7 inhibitor 97491 | SIRT7 inhibitor 97491, a potent SIRT7 inhibitor with an IC50 of 325 nM, reduces deacetylase activity of SIRT7 in a dose-dependent manner. This compound prevents tumor progression by increasing p53 stability through acetylation at K373/382. It promotes apoptosis through caspase pathway. | ||
| S2176 | Tenovin-3 | Tenovin-3 is an inhibitor of SIRT2. This compound is able to increase p53 levels in MCF-7 cells. | ||
| S8000 | Tenovin-1 | Tenovin-1 protects against MDM2-mediated p53 degradation, which involves ubiquitination, and acts through inhibition of protein-deacetylating activities of SirT1 and SirT2. This compound is also an inhibitor of dihydroorotate dehydrogenase (DHODH). |
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| S4900 | Tenovin-6 | Tenovin-6 is a small molecule activator of p53 transcriptional activity and inhibits dihydroorotate dehydrogenase (DHODH). This compound is also an inhibitor of SirT1 and SirT2. |
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| S8942 | Suramin sodium salt | Suramin sodium salt (Suramin hexasodium salt) is a reversible and competitive protein-tyrosine phosphatase (PTPases) inhibitor, also is the potent inhibitor of sirtuins, purified topoisomerase II and SARS-CoV-2 RNA-dependent RNA polymerase (RdRp). |
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