Sirtuin Modulators

Featured Inhibitors
Inhibitors (17)
Modulators (2)
Activators (19)

Cat.No.	Product Name	Information	Product Use Citations	Product Validations
S2298	Fisetin	Fisetin (Fustel) is a potent sirtuin activating compound (STAC) and an agent that modulates sirtuins.	Sci Adv, 2025, 11(17):eads1875 Mol Cancer, 2024, 23(1):222 Cell Death Dis, 2024, 15(8):608
S2347	Quercetin Dihydrate	Quercetin (Sophoretin), a polyphenolic flavonoid found in a wide variety of plant-based foods, such as apples, onions, berries, and red wine, is utilized in many different cultures for their nervous system and anticancer effects. Quercetin (dihydrate), a natural flavonoid, is a stimulator of recombinant SIRT1 and a PI3K inhibitor with IC50s of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively.	ACS Appl Mater Interfaces, 2022, 10.1021/acsami.1c22138 Nucleic Acids Res, 2021, gkab538 Front Immunol, 2021, 12:649285

Cat.No.

Product Name

Information

Product Use Citations

Product Validations

S2298

Fisetin

Fisetin (Fustel) is a potent sirtuin activating compound (STAC) and an agent that modulates sirtuins.

Sci Adv, 2025, 11(17):eads1875

Mol Cancer, 2024, 23(1):222

Cell Death Dis, 2024, 15(8):608

S2347

Quercetin Dihydrate

Quercetin (Sophoretin), a polyphenolic flavonoid found in a wide variety of plant-based foods, such as apples, onions, berries, and red wine, is utilized in many different cultures for their nervous system and anticancer effects. Quercetin (dihydrate), a natural flavonoid, is a stimulator of recombinant SIRT1 and a PI3K inhibitor with IC50s of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively.

ACS Appl Mater Interfaces, 2022, 10.1021/acsami.1c22138

Nucleic Acids Res, 2021, gkab538

Front Immunol, 2021, 12:649285

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