Duvelisib (IPI-145, INK1197)
Catalog No.S7028
Molecular Weight(MW): 416.86
Duvelisib (IPI-145, INK1197) is a novel and selective PI3K δ/γ inhibitor with Ki and IC50 of 23 pM/243 pM and 1 nM/50 nM in cell-free assays, highly selective for PI3K δ/γ than other protein kinases. Phase 3.
Cited by 2 Publications
2 Customer Reviews
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(D-E) The variation of signaling pathway-related and effector proteins after PI3K selective inhibitor INK1197 (Duvelisib) treatment and c-Jun siRNA transfection.
PLoS One, 2016, 11(12):e0169230.. Duvelisib (IPI-145, INK1197) purchased from Selleck.
PI3K inhibitor IPI-145 demonstrated to be effective on ALL-SIL cells,showed an IC50 in the lower micromolar range.
Dr. Antonino Maria Spartà from University of Bolog. Duvelisib (IPI-145, INK1197) purchased from Selleck.
Purity & Quality Control
Choose Selective PI3K Inhibitors
Biological Activity
| Description | Duvelisib (IPI-145, INK1197) is a novel and selective PI3K δ/γ inhibitor with Ki and IC50 of 23 pM/243 pM and 1 nM/50 nM in cell-free assays, highly selective for PI3K δ/γ than other protein kinases. Phase 3. | |||||||||||
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| Targets |
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| In vitro |
IPI-145 suppresses murine/human B-cell proliferation with EC50 of 0.5 nM/0.5 nM and also inhibits human T-cell proliferation with EC50 of 9.5 nM. [1] |
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| In vivo | IPI-145 (10 mg/kg, p.o.) shows well pharmacokinetics with Cmax and AUC of 390 ng/mL and 137 ng•h/mL in mouse and rat. IPI-145 (10 mg/kg) is active in murine DTH model with ~50% ear swelling. IPI-145 (10 mg/kg) demonstrates dose-dependent effect in rat collagen induced arthritis (CIA) model. IPI-145 prevents inflammation and protects joint bone and cartilage in the rat CIA model. IPI-145 (10 mg/kg,QD) demonstrates activity in rat adjuvant induced polyarthritis model. [1] |
Protocol
Solubility (25°C)
| In vitro | DMSO | 83 mg/mL (199.1 mM) |
|---|---|---|
| Water | Insoluble | |
| Ethanol | Insoluble | |
| In vivo | Add solvents individually and in order: 30% PEG400+0.5% Tween80+5% propylene glycol |
30 mg/mL |
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Information
| Molecular Weight | 416.86 |
|---|---|
| Formula | C22H17ClN6O |
| CAS No. | 1201438-56-3 |
| Storage | powder |
| Synonyms | N/A |
Bio Calculators
Molarity Calculator
Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).
Dilution Calculator
Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )
* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).
Molecular Weight Calculator
Enter the chemical formula of a compound to calculate its molar mass and elemental composition:
Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2
Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Molarity Calculator
Clinical Trial Information
| NCT Number | Recruitment | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|
| NCT02292225 | Terminated | Lymphocytic Leukemia, Chronic|Lymphoma, Small Lymphocytic | Verastem, Inc. | February 2015 | Phase 1 |
| NCT02391545 | Active, not recruiting | CD20+ Follicular Lymphoma | Verastem, Inc. | December 2014 | Phase 1|Phase 2 |
| NCT02307461 | Completed | Healthy | Verastem, Inc. | November 2014 | Phase 1 |
| NCT02204982 | Active, not recruiting | Follicular Lymphoma | Verastem, Inc. | September 2014 | Phase 3 |
| NCT02158091 | Active, not recruiting | Chronic Lymphocytic Leukemia | Dana-Farber Cancer Institute|Infinity Pharmaceuticals, Inc. | July 2014 | Phase 1|Phase 2 |
| NCT02095587 | Completed | Hepatic Impairment | Verastem, Inc. | March 2014 | Phase 1 |
Tech Support
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.
Frequently Asked Questions
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Question 1:
Whether IPI-145 S7028 is mixture of two chiral forms, if not, which form is it?
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Answer:
S7028 IPI-145 is S form.
