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PIK-294 Chemical Structure
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Biological Activity
PIK-294 is a highly selective p110 inhibitor with an IC50 of 3 nM. PI3K contains a m-phenol and a pyrazolopyrimidine core. When PIK-294 is compared to tyrosine kinase–selective pyrazolopyrimidines such as PP20, the two molecules span more than 108 fold in relative target selectivity. PIK-294 is 20- to 60-fold more potent than the parent compound, PIK-293, making PIK-294 one of the most potent p110δ- selective inhibitors that has been reported. PIK-294 also inhibits p110α, p110β, p110γ, DNA-PK and mTOR with IC50 of 9.6, 0.67, 0.2, 48 and >50 µM. [1][2]
References on PIK-294
- [] Cell 2006 May 19;125(4): 733–747
- [] Nat Chem Biol 2008 November;4(11): 691–699
Chemical Information
| Molecular Weight (WM): | 489.53 |
|---|---|
| Formula: | C28H23N7O2 |
| CAS No.: | 900185-02-6 |
| Synonyms: |
PIK294
|
| Dissolve in (25°C): | DMSO ≥98mg/mL |
| Water <1mg/mL | |
| Ethanol <1mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
Quality Control & MSDS
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After starved in serum-free medium for 24h,A549 cells incubated with the indicated concentrations of PIK-294 for 3h,followed by 20-minute stimolation of 100ng/ml EGF.
After starved in serum-free medium for 24h,A549 cells incubated with the indicated concentrations of PIK-294 for 3h,followed by 20-minute stimolation of 100ng/ml EGF.
Data independently produced by Dr. Zhang of Tianjin Medical University PIK-294 purchased from Selleck
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After starved in serum-free medium for 24h,A549 cells incubated with the indicated concentrations of PIK-294 for 3h,followed by 20-minute stimolation of 100ng/ml EGF. |
Data independently produced by Dr. Zhang of Tianjin Medical University
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