Pictilisib (GDC-0941)

Catalog No.S1065 Synonyms: RG7321

Pictilisib (GDC-0941) Chemical Structure

Molecular Weight(MW): 513.64

Pictilisib (GDC-0941) is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM in cell-free assays, with modest selectivity against p110β (11-fold) and p110γ (25-fold). Phase 2.

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Cited by 58 Publications

8 Customer Reviews

  • Dual PI3K/BRAF inhibition upregulates BIM and enhances apoptosis in PTEN cells. A, left, Western blot of 1205Lu cells treated with PLX4720 (3 μmol/L, 48 hours), the PI3K inhibitor GDC-0941 (3 μmol/L, 48 hours), or both drugs in combination (PtG); right, immunofluorescence staining of BIM (green) and DAPI (blue) in PTEN cells following PLX4720 treatment (3 μmol/L, 48 hours), the PI3K inhibitor LY294002 (10 μmol/L, 48 hours), or both drugs in combination (PLXtLY). B, left, immunofluorescence staining of PTEN 1205Lu following combined inhibition (3 μmol/L PLX4720 t 10 μmol/L LY294002, 48hours) increases nuclear localization of FOXO3a (green). DAPI is shown in blue. Magnification 40. Right, combined inhibition (3 μmol/L PLX4720 t 10 μmol/L LY294002, 48 hours) increases PTEN WM793 BIM mRNA levels to those observed with single BRAF inhibition (3 μmol/L PLX4720, 48 hours) in the PTENt WM35. C, PTEN cells were treated with PLX4720 (3 μmol/L, 48 hours), GDC-0941 (3 μmol/L, 48hours), or a combination of the 2 drugs (3Pt3G) before Annexin-V staining was analyzed by flow cytometry (*, P < 0.05 between the drug combination and each inhibitor alone). D, combined BRAF/PI3K inhibitor treatment blocks the escape of 1205Lu cells (PTEN) from therapy. Spheroids of 1205Lu cells were treated with either PLX4720 alone (3 and 10 μmol/L: data shows 3 mmol/L), LY294002 (10 μmol/L) alone or a combination of the 2 drugs for 72 hours. In other studies, spheroids were treated with drugs for 72 hours and then allowed to recover for 120 hours. Micrograph shows viability staining (green= live cells, red= dead cells). Magnification 10×.

    Cancer Res 2011 71, 2750-2760. Pictilisib (GDC-0941) purchased from Selleck.

    Combination of rapamycin and PI-103 leads to the suppression of AKT phosphorylation (phospho-specific western blot). Mel-Juso and 518A2 cells were treated with GDC-0941 from 0.05–1 μmol/L alone and in combination with rapamycin (50 nmol/L) for 24 hours. Control treatment was with DMSO.

     

     

    J Inves Der 2010 131, 495-503. Pictilisib (GDC-0941) purchased from Selleck.

  • Growth inhibition induced by the FGFR inhibitor BGJ398 and the PI3K inhibitors alone or in combination. AN3CA (A-C), JHUEM2 (D-F) and MFE296 (G-I) cells were treated with the indicated doses of BGJ398, GDC-0941 a n d BYL719 alone or in combination for 96 hours and an Sulforhodamine B (SRB) assay was subsequently performed. Data are presented as a percentage of the control, in which cells were treated with 0.1% (v/v) DMSO. Points represent the mean of three independent experiments (each performed in triplicate). Error bars represent the standard error of the mean (SEM) and lines were fitted using non-linear regression analysis. Interaction of BGJ398 and GDC-0941(redcircles) or BYL719(blacksquares) in AN3CA(C), JHUEM2(F) and MFE296(I). Median effect analysis was used to evaluate the interaction between the inhibitor combinations. Horizontal dotted lines indicate the boundaries for each interaction classification.

    Mol Cancer Ther, 2017.. Pictilisib (GDC-0941) purchased from Selleck.

    TGF-β induces mTORC2 activation. ( A ) NMuMG cells were treated with TGF-β for the indicated times before lysis and immunoblotting. (B ) NMuMG cells were treated or not with TGF-β for the indicated times, in the presence or absence of SB431542 or LY294002. Cell lysates were subjected to anti-Rictor immunoprecipitation, and the immunoprecipitates were subjected to in vitro kinase assays using kinase-inactive Akt1 as a substrate, before immunoblotting of the kinase reactions, immunoprecipitates and cell lysates. The left panels are from the same gel, without differential exposure. ( C ) NMuMG cells were treated or not with TGF-β or insulin for the indicated times, in the presence or absence of SB431542 or GDC-0941. The kinase activity of mTORC2 was then assessed as in B. The top panels are from the same gel, without differential exposure. (D) NMuMG cells were treated or not with TGF-β for the indicated times, in the presence or absence of SB431542 or LY294002. Cell lysates were subjected to immunoprecipitation using Rictor antibody, and/or immunoblotted.

    J Cell Sci 2012 125(Pt 5), 1259-73. Pictilisib (GDC-0941) purchased from Selleck.

  • Effects of LY294002 and GDC-0941 on the high-glucose-induced plasma membrane translocation of DGK δ1. (A, C) HEK293 cells were transfected with pAcGFP-DGKδ1 or pAcGFP-C1 vector. After being glucose-starved for 2.5 h and the subsequent pretreatment with (A) 10 μM LY294002 (Sigma-Aldrich) or (C) 1 μM GDC-0941 (Selleck Chemicals) for 30 min, the cells were incubated with or without high glucose (25 mM) for 5 min. The cells were fixed with 3.7% formaldehyde and observed using confocal laser-scanning microscopy. Scale bar = 10 μm. (B, D) After treatment with (B) LY294002 or (D) GDC-0941, the percentages of cells exhibiting the translocation of AcGFP-tagged DGK δ 1 to the plasma membrane were scored. More than 20 cells ex-pressing AcGFP-tagged DGK δ1 were counted in each experiment. The results are the means ± S.D. of three independent experiments. The statistical significance was deter-mined using Student's t -test (** P < 0.01, *** P < 0.005)

    Biochim Biophys Acta 2012 1823, 2210-6. Pictilisib (GDC-0941) purchased from Selleck.

    After starved in serum-free medium for 24h, Breast cancer cells incubated with the indicated concentrations of GDC-0941  for 3h,followed by 15-minute  stimulation of 100ng/ml EGF.

     

     

     

    Dr. Zhang of Tianjin Medical University. Pictilisib (GDC-0941) purchased from Selleck.

  • We treated all of drugs in T47D which has a PI3KCA H1044R mutation with the concentration shown below for 1 hour and performed western blot analysis using antibodies to phospho-AKT(SERINE 472), and total AKT.

     

     

    Saraswati Sukumar of Johns Hopkins University School of Medicine. Pictilisib (GDC-0941) purchased from Selleck.

     

    PI3K pathway signaling in GDC-0941 and MK-2206 treated MCF-7 derivatives with PIK3CA or  AKT1 mutations. Cells were grown in medium containing 5% FBS and treated with vehicle or increasing concentrations of GDC-0941 (0 nM, 50 nM, 100 nM, and 400 nM) or MK-2206 (0 nM, 100 nM, 250 nM, 1000 nM). After 24 hours of drug treatment, lysates were prepared and equal amounts of protein were load ed onto SDS-PAGE gels and blotted with the indicated antibodies.

    Pictilisib (GDC-0941) purchased from Selleck.

Purity & Quality Control

Choose Selective PI3K Inhibitors

Biological Activity

Description Pictilisib (GDC-0941) is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM in cell-free assays, with modest selectivity against p110β (11-fold) and p110γ (25-fold). Phase 2.
Targets
p110α [1]
(Cell-free assay)
p110δ [1]
(Cell-free assay)
p110β [1]
(Cell-free assay)
p110γ [1]
(Cell-free assay)
mTOR [1]
(Cell-free assay)
3 nM 3 nM 33 nM 75 nM 0.58 μM(Ki app)
In vitro

GDC-0941 is equipotent against PI3Kα and PI3Kδ as well as PI3Kα mutants E545-K and H1047-R, displaying modest levels of selectivity against PI3Kβ (10-fold) and PI3Kγ (25-fold), and greater levels of selectivity against members of PI3K class II, III, and IV, including C2β, Vps34, DNA-PK, and mTOR. GDC-0941 potently inhibits the phosphorylation of Akt in U87MG, PC3, and MDA-MB-361 cells with IC50 of 46 nM, 37 nM, and 28 nM, respectively. GDC-0941 inhibits the proliferation of U87MG, A2780, PC3, and MDA-MB-361 cells with IC50 of 0.95 μM, 0.14 μM, 0.28 μM, and 0.72 μM, respectively. [1] GDC-0941 treatment potently inhibits the proliferation of both trastuzumab-sensitive and -insensitive HER2-amplified cells with IC50 of 149-944 nM. GDC-0941 inhibits proliferation of HER2-amplified cells that harbor PIK3CA mutations with IC50 of <500 nM, and effectively inhibits both proliferation and viability of HER2-amplified breast cancer cells that are resistant to trastuzumab due to PTEN loss. [2] GDC-0941 significantly inhibits the growth of HCT116, DLD1 and HT29 cells with GI50 of 1081 nM, 1070 nM and 157 nM, respectively. [3] GDC-0941 inhibits tumor cell proliferation, induces apoptosis and suppresses centroblast population. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Sf9 M3TPOmtqdmG|ZTDBd5NigQ>? MkT2NUBp Mne0SG1UVw>? MWHJcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KFCLM1ugdFEyOGSnbIThJIV5eHKnc4Pl[EBqdiCVZkmgZ4VtdHNiY3;lfJBz\XO|aX7nJJA5PWGucHjhJJdqfGhiSVO1NEBw\iByLkCwN{DPxE1? NUDtfVNbOTh5NUS2OVQ>
Sf9 NXLNSY5KU2mwYYPlJGF{e2G7 M1vMeFEhcA>? MV;EUXNQ NHXpfG1KdmirYnn0bY9vKG:oIHj1cYFvKHKnY3;tZolv[W62IGDJN2sheDFzMHLleIEhUDFyNEetVkBufXSjboSg[ZhxemW|c3XkJIlvKFOoOTDj[YxteyClb3X4dJJme3OrbnegdFg2[WyyaHGge4l1cCCLQ{WwJI9nKDBwMECzJO69VQ>? NWfiOllHOTh5NUS2OVQ>
Sf9 MU\LbY5ie2ViQYPzZZk> M{fTXlEhcA>? NITHd4RFVVOR NXK1fWpxUW6qaXLpeIlwdiCxZjDoeY1idiC{ZXPvcYJqdmGwdDDQTVNMKHBzMUDi[ZRiKEV3NEWtT{BufXSjboSg[ZhxemW|c3XkJIlvKFOoOTDj[YxteyClb3X4dJJme3OrbnegdFg2[WyyaHGge4l1cCCLQ{WwJI9nKDBwMECzJO69VQ>? M{ew[FE5PzV2NkW0
Sf9 MULLbY5ie2ViQYPzZZk> MVSxJIg> MnjHSG1UVw>? M4TGSmlvcGmkaYTpc44hd2ZiaIXtZY4hemWlb33ibY5idnRiUFmzT{BxOTFyYnX0ZUBmgHC{ZYPz[YQhcW5iU3[5JINmdGy|IHPv[ZhxemW|c3nu[{BxQDWjbIDoZUB4cXSqIFnDOVAhd2ZiMD6wN|Mh|ryP NWm2WXBnOTh5NUS2OVQ>
Sf9 M{K5[mtqdmG|ZTDBd5NigQ>? MXOxJIg> M4HkUGROW09? M13j[2lvcGmkaYTpc44hd2ZiaIXtZY4hemWlb33ibY5idnRiUFmzT{BxOTFyYXzwbIEh\XiycnXzd4VlKGmwIGPmPUBk\WyuczDjc4V5eHKnc4PpcocheDh3YXzwbIE> MVOxPFc2PDZ3NB?=
MDA-MB-361 MVLGeY5kfGmxbjDBd5NigQ>? MkHuNkBp M2m0U2ROW09? NUPrcpNHUW6qaXLpeIlwdiCxZjDBb5QhW2W{NEezJJBpd3OyaH;yfYxifGmxbjDpckBpfW2jbjDNSGEuVUJvM{[xJINmdGy|IIfpeIghWEmNM1PBJGU2PDVvSzDteZRifGmxbjD3bZRpKEmFNUCgc4YhOC5yMkig{txO M1Gwd|E5PzV2NkW0
PC3 M3;NUGZ2dmO2aX;uJGF{e2G7 NWmwfHNIOiCq NWfNd4s2TE2VTx?= Mn7ETY5pcWKrdHnvckBw\iCDa4SgV4VzPDd|IIDoc5NxcG:{eXzheIlwdiCrbjDQWGVPNW63bHygbJVu[W5iUFOzJINmdGy|IIfpeIghUUN3MDDv[kAxNjB|NzFOwG0> M{XE[FE5PzV2NkW0
U87MG MlH6SpVv[3Srb36gRZN{[Xl? NFrse2UzKGh? NGT3ZoRFVVOR MUXJcohq[mm2aX;uJI9nKEGtdDDT[ZI1PzNicHjvd5Bpd3K7bHH0bY9vKGmwIGDUSW4udnWubDDoeY1idiCXOEfNS{Bk\WyuczD3bZRpKEmFNUCgc4YhOC5yNE[g{txO NH3uNFQyQDd3NE[1OC=>
MDA-MB-361 NEiyVJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3PjXVk3KGh? Mn3SSG1UVw>? MWfBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2GQT3NRk0{PjFiY3XscJMhf2m2aDDQTWs{S0FiRUW0OU1MKG23dHH0bY9vKHerdHigTWM2OCCxZjCwMlczKM7:TR?= NX20XZBqOTh5NUS2OVQ>
A2780 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjwWWM6PiCq NUW3eo1iTE2VTx?= MUDBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEF{N{iwJINmdGy|IIfpeIghWEmNM1PBJIFv\CCSVFXOJI12fGG2aX;uJJdqfGhiSVO1NEBw\iByLkG0JO69VQ>? MlT5NVg4PTR4NUS=
PC3 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEXPS|U6PiCq NUPsb|RvTE2VTx?= MUHJR|UxRTBwMkig{txO MlrsNVg4PTR4NUS=
U87MG MofBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEPoXZY6PiCq NWrCSFJ6TE2VTx?= NVfKeFN{UUN3ME2wMlk2KM7:TR?= Mlu5NVg4PTR4NUS=
Sf9 NX\m[lJuU2mwYYPlJGF{e2G7 NX;0O|ZLOzBibXnu MV3EUXNQ MUXJcohq[mm2aX;uJI9nKGi3bXHuJHBKO0upYX3tZUBmgHC{ZYPz[YQh[XO|ZYPz[YQh[XNiYX3veY51KG:oIFHUVEBkd26|dX3l[EB4cXSqIFnDOVAhd2ZiMD6wOFIh|ryP NXLENoJrOjJ3NEizOFI>
RAW 264.7 NGDsU2xMcW6jc3WgRZN{[Xl? Mlr3PVAhdWmw NF;KcoRFVVOR NF;YWmFKdmirYnn0bY9vKG:oIHj1cYFvKFCLM1vnZY1u[SCneIDy[ZN{\WRiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCDS2SgdIhwe3Cqb4L5cIF1cW:wIIfpeIghUUN3MDDv[kAxNjJ7ODFOwG0> MonGNlI2PDh|NEK=
Sf9 NEO4[JJMcW6jc3WgRZN{[Xl? NX3h[HQzOSCq NI[ydGFKdmirYnn0bY9vKG:oIFfTWE1nfXOnZDDoeY1idiC{ZXPvcYJqdmGwdDDQTVNM[mW2YTDlfJBz\XO|ZXSgbY4h[mGldXzveolzfXNiaX7m[YN1\WRiU1[5JINmdGy|IIfpeIghUUN3MDDv[kAxNjBzNzFOwG0> NVXq[VFwOjN3NEC2OFU>
Sf9 NELXNYdMcW6jc3WgRZN{[Xl? M3y2TlEhcA>? M2nzZmlvcGmkaYTpc44hd2ZiR2PUMYZ2e2WmIHj1cYFvKHKnY3;tZolv[W62IGDJN2tl\Wy2YTDlfJBz\XO|ZXS= NFfmUpIzOzV2ME[0OS=>
Sf9 MVXLbY5ie2ViQYPzZZk> M3TiO|EhcA>? MofnTY5pcWKrdHnvckBw\iCJU2St[pV{\WRiaIXtZY4hemWlb33ibY5idnRiUFmzT4didW2jIHX4dJJme3OnZB?= M1vLdFI{PTRyNkS1
Sf9 M2HkbGtqdmG|ZTDBd5NigQ>? M4GwTlEhcA>? M2OwV2lvcGmkaYTpc44hd2ZiR2PUMYZ2e2WmIHj1cYFvKHKnY3;tZolv[W62IGDJN2tidHCqYTDlfJBz\XO|ZXS= NFr5ZVUzOzV2ME[0OS=>
SKOV3 MoT0T4lv[XOnIFHzd4F6 NI\ZOnUyKM7:TR?= M3rFTlEhcA>? MnvXSG1UVw>? NFHCTZhKdmirYnn0bY9vKG:oIGDJN2tidHCqYTDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIFHreEBU\XJ2N{OgdIhwe3Cqb4L5cIF1cW:w M2\qPFI{OzZyM{S4
MCF7 MlrPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnPuNUDPxE1? MVe5OkBp MVHEUXNQ M{WwcGdKPTB;MD6wO|AzKM7:TR?= MmfYNlM{PjB|NEi=
SKOV3 NHP2UYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVyxJO69VQ>? MU[5OkBp MoHQSG1UVw>? MWjHTVUxRTBwMUS3OkDPxE1? M2TYWlI{OzZyM{S4
PC3 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3XOclczKGh? MnnKSG1UVw>? NHHsV2tKSzVyPUCuNlgh|ryP MUiyNVk5OTdzNB?=
MCF7.1 NFH3UmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGroUGU4OiCq MnXuSG1UVw>? NWflcZZOSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNR2Y4NjFiY3XscJMh\XiycnXzd4lv\yCKRWKyJIdmdmVid3n0bEBKSzVyIH;mJFAvOjhizszN MUCyNVk5OTdzNB?=
MCF7-neo/Her2 Mnr6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4D4e|czKGh? MX\EUXNQ Mm\qTWM2OD1yLkK5JO69VQ>? MXiyN|Y3OjlyMx?=
MCF7-neo/Her2 NEfDZ|RMcW6jc3WgRZN{[Xl? MlH6TY5pcWKrdHnvckBw\iCSSUPLZYxxcGFiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJI9nKEGNVDDwbI9{eGixconsZZRqd25iYYSgV|Q4OyC5aYToJGlEPTBib3[gNE4xODdizszN M{HsN|I{PjZ{OUCz
PC3 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHfUd4o4OiCq MU\EUXNQ MUDFR|UxRTBwM{Sg{txO MVuyNVk5PTZ|OR?=
MCF7.1 M2W1PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUHBW2hyPzJiaB?= M3PLUmROW09? MVHBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2FRkeuNUBk\WyuczDlfJBz\XO|aX7nJHBKO0ujbIDoZUBufXSjboSge4l1cCCHQ{WwJI9nKDBwM{mg{txO MmHuNlE6QDV4M{m=
PC3 MlPBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYTpe5RMPzJiaB?= MVTEUXNQ MnrFRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCSQ{OgZ4VtdHNiZHXmbYNq\W62IHnuJHBVTU5id3n0bEBKSzVyIH;mJFAvOzlizszN M3r2UFIxODVyNk[5
MCF7.1 M13jSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn3sO|IhcA>? MnXFSG1UVw>? MlPhRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPQ1[3MlEh[2WubIOg[ZhxemW|c3nu[{BRUTONYXzwbIEhdXW2YX70JJdqfGhiSVO1NEBw\iByLkO0JO69VQ>? Mn;KNlAxPTB4Nkm=
MCF7.1 NHLpSnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2nldFczKGh? NETSV4dGSzVyPUCuO|Ih|ryP M1jETVIxOzR4NkW2
NCI-H1975 MUnDfZRwfG:6aXOgRZN{[Xl? NEnUO4M4OiCq MnHmTWM2OD1yLkK3JO69VQ>? M3rOXFI{ODV7NUS1
H460 M{XRUGN6fG:2b4jpZ{BCe3OjeR?= NUC4[Gh2PzJiaB?= M2fvTWlEPTB;MD64O{DPxE1? NH\qcoszOzB3OUW0OS=>
HT-29 NFLI[VdEgXSxdH;4bYMhSXO|YYm= NYjBNnpzPzJiaB?= MV3JR|UxRTBwNk[g{txO Mo\oNlMxPTl3NEW=
HepG2 NF\5b21EgXSxdH;4bYMhSXO|YYm= MknLO|IhcA>? NY\nZWh7UUN3ME2xJO69VQ>? M3PHOFI{ODV7NUS1
SGC7901 NV7XOYxqS3m2b4TvfIlkKEG|c3H5 NYO5NFB7PzJiaB?= M1z4R2lEPTB;MT64JO69VQ>? M3HMd|I{ODV7NUS1
NCI-H226 NW[1fHo1S3m2b4TvfIlkKEG|c3H5 M{XiT|czKGh? NFj0emxKSzVyPUKuPUDPxE1? MkT0NlMxPTl3NEW=
A549 MV;DfZRwfG:6aXOgRZN{[Xl? MWS3NkBp MVrJR|UxRTZwOTFOwG0> M1fKTFI{ODV7NUS1
U87MG MYDDfZRwfG:6aXOgRZN{[Xl? MWG3NkBp M2nNNmlEPTB;Nz63O{DPxE1? MWGyN|A2QTV2NR?=
HBC4 M{PDXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\xd4xw\0eLNUC9MVYvODNiTR?= MnvQNlI{OzZ{NE[=
BSY1 Mk[yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NILhZXVtd2eJSUWwQU03NjlyIF2= NXLjd5RuOjJ|M{[yOFY>
HBC5 Mn;CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGrv[ohtd2eJSUWwQU03NjZyIF2= MkfHNlI{OzZ{NE[=
MCF7 MnHyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnT0cI9oT0l3ME2tO{4{OyCP NGr1U28zOjN|NkK0Oi=>
MDA-MB-231 MlzES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTsc4dIUTVyPT21MlQ3KE1? MWmyNlM{PjJ2Nh?=
U251 NXrVbo1mT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDo[pZtd2eJSUWwQU02NjVyIF2= NV7BdWxHOjJ|M{[yOFY>
SF268 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{fuVoxw\0eLNUC9MVUvOzliTR?= M2LGVVIzOzN4MkS2
SF295 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmWwcI9oT0l3ME2tOk4{PyCP MX6yNlM{PjJ2Nh?=
SF539 Mn;4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjhcI9oT0l3ME2tOk42OCCP M2\rPVIzOzN4MkS2
SNB75 MoXQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\sc4dIUTVyPT23MlExKE1? MWqyNlM{PjJ2Nh?=
SNB78 MoD2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4i0VIxw\0eLNUC9MVYvPTJiTR?= NF3BT2ozOjN|NkK0Oi=>
HCC2998 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELmO4ttd2eJSUWwQU03NjJ7IF2= NFzwW|gzOjN|NkK0Oi=>
KM12 M1;hSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3nudoxw\0eLNUC9MVUvPzZiTR?= NHjzcIgzOjN|NkK0Oi=>
HT-29 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4DQeYxw\0eLNUC9MVYvOzBiTR?= MXiyNlM{PjJ2Nh?=
HCT15 Mn;nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MonscI9oT0l3ME2tOk4yOiCP MWqyNlM{PjJ2Nh?=
HCT116 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV:0XFhpdG:pR1m1NF0uPS56NzDN NGi1[VUzOjN|NkK0Oi=>
NCI-H23 NH\vSoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfTcI9oT0l3ME2tOU44OyCP MV2yNlM{PjJ2Nh?=
NCI-H226 Ml3WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnPRcI9oT0l3ME2tOk4zOSCP Ml\QNlI{OzZ{NE[=
NCI-H522 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml63cI9oT0l3ME2tOk42QCCP MVOyNlM{PjJ2Nh?=
NCI-H483 NIPEV|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHsc4dIUTVyPT22MlU3KE1? NXLCO2N4OjJ|M{[yOFY>
A549 NUHIR49xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYH3[mlydG:pR1m1NF0uPi5zNTDN NEnkPJAzOjN|NkK0Oi=>
DMS273 NEG3Um9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnvUcI9oT0l3ME2tOk41OyCP MoTMNlI{OzZ{NE[=
DMS114 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHH0S|Ftd2eJSUWwQU02Njl{IF2= MkPXNlI{OzZ{NE[=
LOXIMVI NUj3VVVMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHKyXZRtd2eJSUWwQU03NjJ7IF2= MYWyNlM{PjJ2Nh?=
OVCAR3 NYrodZo{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NILad|dtd2eJSUWwQU03NjdzIF2= NX3o[WU1OjJ|M{[yOFY>
OVCAR4 Mlf0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1fz[Yxw\0eLNUC9MVUvPzZiTR?= MWWyNlM{PjJ2Nh?=
OVCAR5 M3TuOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4nuV4xw\0eLNUC9MVYvOjZiTR?= MXqyNlM{PjJ2Nh?=
OVCAR8 NF7wO4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIS3epltd2eJSUWwQU02Njd|IF2= M4H6bFIzOzN4MkS2
SKOV3 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHzCdphtd2eJSUWwQU03NjV{IF2= MlzjNlI{OzZ{NE[=
RXF631L MlzKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M171T4xw\0eLNUC9MVYvQDhiTR?= MoXwNlI{OzZ{NE[=
ACHN MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFH4fnBtd2eJSUWwQU03NjB5IF2= NVX6WoNIOjJ|M{[yOFY>
St-4 MkW5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXzL[opSdG:pR1m1NF0uPS53NjDN NIfNfWQzOjN|NkK0Oi=>
MKN1 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGnqWlBtd2eJSUWwQU04NjB6IF2= NFrTe|QzOjN|NkK0Oi=>
MKN7 NVzoTpcxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVzObIRCdG:pR1m1NF0uPi53MDDN NUe5bW9KOjJ|M{[yOFY>
MKN28 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVu0c252dG:pR1m1NF0uPS53MjDN Ml3NNlI{OzZ{NE[=
MKN45 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYPHV4YydG:pR1m1NF0uPi53NTDN MVGyNlM{PjJ2Nh?=
MKN74 NV7V[lBPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1PyfYxw\0eLNUC9MVYvODJiTR?= NXLqXnc{OjJ|M{[yOFY>
DU145 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\v[ZJtd2eJSUWwQU02Njh3IF2= NUHDd3RZOjJ|M{[yOFY>
PC3 Mo[yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX\tcnh4dG:pR1m1NF0uPi54NjDN M{jXdlIzOzN4MkS2
ES5 MlTrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlnCTWM2OD13MD6yNUBvVQ>? M3XKVnNCVkeHUh?=
HH MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLJR|UxRTFzMT6wPEBvVQ>? MnXSV2FPT0WU
MHH-PREB-1 NIXBO5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTFzND6zJI5O NXHvRmhLW0GQR1XS
NCI-H1770 NX[4WI01T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEn5U4dKSzVyPUGyN{45PiCwTR?= NHzBdo1USU6JRWK=
HuO9 NIPYcFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3;OPGlEPTB;MkC2MlAzKG6P MnXvV2FPT0WU
HAL-01 M4f6Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4TkO2lEPTB;MkC2Mlc{KG6P MUTTRW5ITVJ?
NOS-1 M4foPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmDBTWM2OD1{MUGuPFIhdk1? NVrhTHRyW0GQR1XS
HGC-27 NHS4TFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2DzRmlEPTB;MkGyMlU4KG6P M2DtZnNCVkeHUh?=
NB69 M4HHNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTJ2NT6yO{BvVQ>? MUHTRW5ITVJ?
RS4-11 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEfO[FNKSzVyPUK2NU44PiCwTR?= Ml3BV2FPT0WU
DOK MlP5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1nBXmlEPTB;M{CxMlchdk1? NFvHU3VUSU6JRWK=
LB2241-RCC NV\HZXpCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3vHVmlEPTB;M{CzMlg1KG6P M2\mU3NCVkeHUh?=
NCI-H1623 NU\2VnVQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkW3TWM2OD1|MESuNFghdk1? Ml;hV2FPT0WU
YH-13 NHvoT2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFLiW5pKSzVyPUOwOE4{OiCwTR?= NYOzU4JiW0GQR1XS
BPH-1 M4fUfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{HkNWlEPTB;M{G0JI5O NFrxWYZUSU6JRWK=
AN3-CA MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTN2MD6zO{BvVQ>? NYTLbpV1W0GQR1XS
ES7 MorSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTN2MT65PUBvVQ>? MkLlV2FPT0WU
MDA-MB-175-VII M3vMeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX3JR|UxRTN3Mj65NkBvVQ>? M4XNNnNCVkeHUh?=
GAMG Mln6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTN5MD64OUBvVQ>? Mk\qV2FPT0WU
CHL-1 NVn4[VM6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk\iTWM2OD1|N{iuOlUhdk1? M1v2OXNCVkeHUh?=
NB7 NVnFc3pDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWfmNZJXUUN3ME2zPFkvQDNibl2= NWLh[HdWW0GQR1XS
MFE-280 M1zmVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTRzOD6yJI5O NGK1bHRUSU6JRWK=
HL-60 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3rleGlEPTB;NEK1Mlc2KG6P MlyzV2FPT0WU
GCIY NFfldHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTR|Mz64JI5O MknnV2FPT0WU
MDA-MB-361 Mn;WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTR|OT6xN{BvVQ>? MkHyV2FPT0WU
LXF-289 M4XzUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{G1NWlEPTB;NES4MlI4KG6P NHT0bmZUSU6JRWK=
NBsusSR MoDhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXrJPHN7UUN3ME20PFgvQDVibl2= M1PyNnNCVkeHUh?=
KU-19-19 M{nxZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnnrTWM2OD13MU[uNFchdk1? NVrsUmlyW0GQR1XS
A204 NIj1VnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUf5R49RUUN3ME21NlIvOzNibl2= MYDTRW5ITVJ?
LB1047-RCC M{HjbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\kR3NVUUN3ME21NlIvQTNibl2= MmrMV2FPT0WU
COLO-684 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIDCb5NKSzVyPUWyN{4yOSCwTR?= M4jneHNCVkeHUh?=
PA-1 NGrJWppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHLOWtrUUN3ME21N|IvPDFibl2= Ml\WV2FPT0WU
MG-63 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUTKbVR[UUN3ME21OFEvOTFibl2= MWDTRW5ITVJ?
BHT-101 NEDTUXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3GwO2lEPTB;NUS0Mlk1KG6P MWrTRW5ITVJ?
NKM-1 Mo\GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\WTWM2OD13OUOuNFkhdk1? M2XCUnNCVkeHUh?=
T47D M3S4O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1LuTmlEPTB;NUm3MlU3KG6P MWfTRW5ITVJ?
MOLT-4 MlP3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\EW4NkUUN3ME22NlMvPjJibl2= MnXCV2FPT0WU
IGROV-1 M3:2[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4qyRmlEPTB;NkO0MlMyKG6P MlvTV2FPT0WU
ES4 NHj3PGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTZ|OT61OEBvVQ>? MVTTRW5ITVJ?
HuO-3N1 MlHTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYL2WoVRUUN3ME22OFIvOzhibl2= MVfTRW5ITVJ?
NEC8 NETEfnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTZ3Mz61O{BvVQ>? Mo\EV2FPT0WU
HO-1-N-1 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTZ3OT6xO{BvVQ>? NHHrXlJUSU6JRWK=
EPCL-272H Mn74S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnO5TWM2OD14OEeuNlEhdk1? MXjTRW5ITVJ?
D-263MG NYizWnlKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M17sWGlEPTB;N{G4MlEhdk1? MX;TRW5ITVJ?
MV-4-11 NITSe5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlTMTWM2OD15MkSuN|Ehdk1? NHWwOJBUSU6JRWK=
SK-NEP-1 MnrBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTd{NT65OEBvVQ>? M3TZTXNCVkeHUh?=
SW872 NFq5VHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRTd{Nz64PUBvVQ>? NUjMU5RjW0GQR1XS
P30-OHK MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlnvTWM2OD15M{CuO|Ehdk1? MWnTRW5ITVJ?
OMC-1 Ml;jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vtN2lEPTB;N{WxMlA6KG6P MljYV2FPT0WU
LoVo NEPwZ2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLhWVl{UUN3ME23O|cvQSCwTR?= M13SZnNCVkeHUh?=
LNCaP-Clone-FGC NUKzNYhVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUPQT3FyUUN3ME23PVYvOzRibl2= MmXCV2FPT0WU
L-363 Mnf6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml7FTWM2OD15OUiuOFIhdk1? NWezXIhqW0GQR1XS
ES8 NV\SU2RQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHHvcJlKSzVyPUixNE42OiCwTR?= NXjibI9LW0GQR1XS
697 M1HnXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHe4VndKSzVyPUizNU42PSCwTR?= MlLsV2FPT0WU
HSC-3 NGnLNIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1PVTGlEPTB;OEO5MlU1KG6P NFfvVnZUSU6JRWK=
H4 NG\YVFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljlTWM2OD16NUCuPFUhdk1? NGHnOW9USU6JRWK=
QIMR-WIL M3vrbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTQTWM2OD16NkWuNkBvVQ>? NGfSTJdUSU6JRWK=
OAW-42 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXXsbmx4UUN3ME24O|IvOTlibl2= NEjOd2dUSU6JRWK=
MCF7 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTh7OD61PUBvVQ>? MV3TRW5ITVJ?
SCC-25 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTlzND6xPUBvVQ>? Mkm0V2FPT0WU
NCI-H1563 NV\xZYZXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXPSOmRnUUN3ME25NVUvQTlibl2= MV;TRW5ITVJ?
OVCAR-5 M1jtfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTl2MD6xO{BvVQ>? NV\USoZWW0GQR1XS
HDLM-2 NInGdJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1nFe2lEPTB;OUS5MlIhdk1? M4O1N3NCVkeHUh?=
NB5 NH3CO3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV7KeVd3UUN3ME25OVYvPiCwTR?= Ml7aV2FPT0WU
NCI-H292 NH\hT4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTl5ND6zNkBvVQ>? MXnTRW5ITVJ?
A101D M2DGTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{jCNmlEPTB;OUmwMlE6KG6P NV\wSnl[W0GQR1XS
NCI-H1648 MoHhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVzNZYQ{UUN3ME25PVgvPTFibl2= M4nybHNCVkeHUh?=
EKVX Mk\GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnPOTWM2OD1zLkCxNlkh|ryP MYfTRW5ITVJ?
SW1710 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVHiXYxQUUN3ME2xMlA1OjN|IN88US=> MWnTRW5ITVJ?
WM-115 NHfzR5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFnoWWdKSzVyPUGuNFY3PTZizszN NGi3bFRUSU6JRWK=
CAL-54 M2HFbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3yxS2lEPTB;MT6wO|A5OSEQvF2= MkTYV2FPT0WU
TGBC24TKB MmTBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXnwVlc{UUN3ME2xMlA5ODR3IN88US=> MUjTRW5ITVJ?
NCI-H520 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUTPc4hWUUN3ME2xMlA5QTZ5IN88US=> MkOxV2FPT0WU
D-423MG NVHW[lBzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTFwMEm5OlIh|ryP NITJcZVUSU6JRWK=
BFTC-905 M4j2WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEfLdopKSzVyPUGuNVM1PDlizszN MnjMV2FPT0WU
HT MnflS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MofFTWM2OD1zLkGzOFc5KM7:TR?= M4DocnNCVkeHUh?=
CTB-1 M1vxUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXHyOnYzUUN3ME2xMlE1Ojl|IN88US=> M33VUXNCVkeHUh?=
Hs-578-T MoDhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTFwMUm1OlUh|ryP NHG0bJpUSU6JRWK=
HuH-7 MmnvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NInHNHFKSzVyPUGuNlA6PDlizszN MonQV2FPT0WU
LB996-RCC M13M[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTFwMkKxO|ch|ryP MlHtV2FPT0WU
KYSE-270 MmHuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGfwNWZKSzVyPUGuNlk4OzRizszN NXLINFN{W0GQR1XS
A4-Fuk MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV6xNWFxUUN3ME2xMlI6QTl|IN88US=> M3LKSHNCVkeHUh?=
A498 NFGwSGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFWwSodKSzVyPUGuN|A1PzRizszN Ml;DV2FPT0WU
SK-MEL-1 NYrLc3M3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFPmPXFKSzVyPUGuN|A3PzlizszN MVPTRW5ITVJ?
AU565 MlvQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\i[otxUUN3ME2xMlMyQDZ|IN88US=> MWrTRW5ITVJ?
Saos-2 M3PNUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTFwM{OyNFUh|ryP NHzVN25USU6JRWK=
A549 Mnq4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTFwM{m5O{DPxE1? MVrTRW5ITVJ?
BFTC-909 NYrIfldHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2Xp[mlEPTB;MT60N|MxPSEQvF2= MlO4V2FPT0WU
MDA-MB-415 NEnjO2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUjJXml6UUN3ME2xMlQ5Pjl{IN88US=> NITpe2dUSU6JRWK=
639-V NELRR2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkHNTWM2OD1zLkWwNlQ2KM7:TR?= MnvFV2FPT0WU
A704 M2i0[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm[0TWM2OD1zLkWwO|g2KM7:TR?= NIPzVIpUSU6JRWK=
PANC-03-27 MmflS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MojQTWM2OD1zLkWxOFA5KM7:TR?= NG\aN|hUSU6JRWK=
SK-MEL-28 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTFwNU[wPFUh|ryP NEjZTpNUSU6JRWK=
Ramos-2G6-4C10 MmTqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXHGOI1yUUN3ME2xMlYxPzR4IN88US=> NV;pclZEW0GQR1XS
HuP-T4 M3vqOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXXJR|UxRTFwNkC3O|gh|ryP NHXnWpNUSU6JRWK=
VA-ES-BJ NXvZdoVnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVjzSnlSUUN3ME2xMlYyOjdizszN NHvrXnJUSU6JRWK=
EFM-19 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYLSW3NJUUN3ME2xMlYyQDFizszN NXjjb2hvW0GQR1XS
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D-566MG MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3PBfGlEPTB;MT62NlU{KM7:TR?= MnvsV2FPT0WU
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SW13 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFXJcmlKSzVyPUK5Mlg2OTlizszN NGe5UG1USU6JRWK=
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NCI-H661 MmTiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm[xTWM2OD1|Mj6wOlI{KM7:TR?= NGflcGZUSU6JRWK=
NCI-H2347 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTN{LkS4N|ch|ryP MUDTRW5ITVJ?
FTC-133 M3jxOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkfPTWM2OD1|Mj63NFYh|ryP MnXDV2FPT0WU
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GOTO MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4nZPGlEPTB;M{OuOVI2QCEQvF2= Mk\sV2FPT0WU
YAPC NVPFe45XT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVL6NXhEUUN3ME2zN{45OTV7IN88US=> NXLneWVmW0GQR1XS
LCLC-103H NYHwUoZ[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NETmTJhKSzVyPUO0MlE3OjRizszN M1jTOXNCVkeHUh?=
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KP-N-YS NH61dY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWPsfWRPUUN3ME2zOE44OjB{IN88US=> MmXRV2FPT0WU
NCI-SNU-1 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlPUTWM2OD1|NT6xO|kh|ryP M{fuVXNCVkeHUh?=
KNS-81-FD NEPvPYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTN3Lk[2N{DPxE1? NV;WeHZZW0GQR1XS
SCC-9 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTN4LkexOFYh|ryP M4HtZnNCVkeHUh?=
SH-4 NWXaO|lCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEjVNFRKSzVyPUO2Mlc{KM7:TR?= NU\1OZUyW0GQR1XS
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COLO-678 M2Lr[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3z5TmlEPTB;M{euPVQ{PyEQvF2= M3nKTHNCVkeHUh?=
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OAW-28 MkfMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1rlb2lEPTB;M{iuOlM6KM7:TR?= NETHN3hUSU6JRWK=
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A3-KAW NEnQPXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYO0enhnUUN3ME20NE4{PjZzIN88US=> MmXoV2FPT0WU
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KYSE-140 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF3LPGNKSzVyPUSwMlcyPjVizszN NHK3SIhUSU6JRWK=
MOLT-16 NXqwbHBTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHmz[m1KSzVyPUSxMlE2OzZizszN MoXDV2FPT0WU
CFPAC-1 M4jPbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFG5bIZKSzVyPUSyMlUzOTFizszN NF3uUpBUSU6JRWK=
NB14 Mlv4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPYdpZ7UUN3ME20Nk44ODJ5IN88US=> M4PoOXNCVkeHUh?=
COLO-792 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYXpblV5UUN3ME20Nk45QTZzIN88US=> M4LNXHNCVkeHUh?=
RH-1 NFPUVldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XsSGlEPTB;NEOuOFg{PiEQvF2= NFrVfIpUSU6JRWK=
NCI-H522 NHfiO|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NILlVWVKSzVyPUS0MlM2PjhizszN MY\TRW5ITVJ?
Ca-Ski MnjVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVXXXmJjUUN3ME20OE45OTF2IN88US=> M{fsSnNCVkeHUh?=
KGN NIriWJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3HvcWlEPTB;NEiuN|A3OyEQvF2= M2LaeHNCVkeHUh?=
UACC-62 MmfHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{DU[GlEPTB;NEiuOFA4OiEQvF2= M2i3R3NCVkeHUh?=
NCI-H358 NYHwO2lFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFPBNYxKSzVyPUS5MlMxOThizszN M4fnV3NCVkeHUh?=
LS-411N MlfUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYr4fWx4UUN3ME20PU4{OTF6IN88US=> M4XOPXNCVkeHUh?=
IST-MES1 M1LuXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTR7LkW2NlUh|ryP MV\TRW5ITVJ?

... Click to View More Cell Line Experimental Data

In vivo Administration of GDC-0941 at 75 mg/kg/day displays significant inhibitory effect against established human U87MG glioblastoma xenografts in female NCr athymic mice, with tumor growth inhibition of 83%. [1] Oral administration of GDC-0941 at 150 mg/kg/day inhibits the growth of HER2-amplified, trastuzumab-resistant MDA-MB-361.1 xenografts in mice, and significantly delays the tumor progression, in association with potent induced apoptosis in tumors. [2] GDC-0941 (75 mg/kg/day) treatment for 2 weeks induces ~40% reduction in tumor volume of spontaneous B-cell follicular lymphomas developed in PTEN+/-LKB1+/hypo mice, accompanied by ablation of phosphorylation of Akt, S6K and SGK (serum and glucocorticoid protein kinase) protein kinases. [4]

Protocol

Kinase Assay:[1]
+ Expand

Scintillation proximity assay:

Recombinant human PI3Kα, PI3Kβ, and PI3Kδ are coexpressed in a Sf9 baculovirus system with the p85α regulatory subunit and purified as GST-fusion proteins using affinity chromatography on glutathione-sepharose. Recombinant human PI3Kγ is expressed as monomeric GST-fusions and purified similarly. GDC-0941 is dissolved in DMSO and added to 20 mM Tris-HCl (pH 7.5) containing 200 μg yttrium silicate (Ysi) polylysine SPA beads, 4 mM MgCl2, 1 mM dithiothreitol (DTT), 1 μM ATP, 0.125 μCi [γ-33P]-ATP, and 4% (v/v) DMSO in a total volume of 50 μL. The recombinant GST-fusion of PI3Kα (5 ng), PI3Kβ (5 ng), PI3Kδ (5 ng), or PI3Kγ (5 ng) is added to the assay mixture to initiate the kinase reaction. After incubation for 1 hour at room temperature, the kinase reaction is terminated with 150 μL PBS. The mixture is then centrifuged for 2 minutes at 2000 rpm and read using a Wallac Microbeta counter. The reported IC50 values are calculated using a sigmoidal, dose-response curve fit in MDL Assay Explorer.
Cell Research:[2]
+ Expand
  • Cell lines: SKBR-3, BT474-M1, AU-565, HCC-1419, ZR75-30, KPL-4, JIMT-1, BT474-EEI, HCC-1954, MCF-7, CALU-3, SKOV-3, and MKN-7 cells
  • Concentrations: Dissolved in DMSO, final concentrations ~10 μM
  • Incubation Time: 48 and 72 hours
  • Method: Cells are exposed to various concentrations of GDC-0941 for 48, and 72 hours. Proliferation/viability of cells is detected by using the CellTiter-Glo Luminescent Cell Viability Assay. The pAkt (Ser473), cleaved caspase-3, and cleaved PARP are analyzed by western blot. The Caspase-Glo 3/7 assay and the Cell Death Detection ELISAplus assay are used to detect caspase 3/7 activity, and apoptosis, respectively.
    (Only for Reference)
Animal Research:[2]
+ Expand
  • Animal Models: NCR nude mice implanted with MDA-MB-361.1 cells, and SCID, C.B-17/IcrHsd-Prkdcscid mice implanted subcutaneously with BT474-M1 cells
  • Formulation: Dissolved in 10% DMSO, 5% Tween 20, 85% water
  • Dosages: ~150 mg/kg/day
  • Administration: Oral gavage
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 44 mg/mL (85.66 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents individually and in order:
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
5mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 513.64
Formula

C23H27N7O3S2

CAS No. 957054-30-7
Storage powder
in solvent
Synonyms RG7321

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

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  • Computed Result

  • C1=C0/X C1: LOG(C1):
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    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
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Molecular Weight Calculator

Molecular Weight Calculator

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00999128 Completed Healthy Volunteers Genentech, Inc. October 26, 2009 Phase 1
NCT02092831 Completed Healthy Volunteer Genentech, Inc. April 2014 Phase 1
NCT01740336 Active, not recruiting Breast Cancer Genentech, Inc. February 2013 Phase 2
NCT01493843 Completed Non-Squamous Non-Small Cell Lung Cancer Genentech, Inc. January 2012 Phase 2
NCT01474668 Completed Healthy Volunteer Genentech, Inc. October 2011 Phase 1
NCT01437566 Completed Breast Cancer Genentech, Inc. October 2011 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

PI3K Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID