Pictilisib (GDC-0941)

Catalog No.S1065 Synonyms: RG7321

Pictilisib (GDC-0941) Chemical Structure

Molecular Weight(MW): 513.64

Pictilisib (GDC-0941) is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM in cell-free assays, with modest selectivity against p110β (11-fold) and p110γ (25-fold). Phase 2.

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Cited by 57 Publications

7 Customer Reviews

  • Dual PI3K/BRAF inhibition upregulates BIM and enhances apoptosis in PTEN cells. A, left, Western blot of 1205Lu cells treated with PLX4720 (3 μmol/L, 48 hours), the PI3K inhibitor GDC-0941 (3 μmol/L, 48 hours), or both drugs in combination (PtG); right, immunofluorescence staining of BIM (green) and DAPI (blue) in PTEN cells following PLX4720 treatment (3 μmol/L, 48 hours), the PI3K inhibitor LY294002 (10 μmol/L, 48 hours), or both drugs in combination (PLXtLY). B, left, immunofluorescence staining of PTEN 1205Lu following combined inhibition (3 μmol/L PLX4720 t 10 μmol/L LY294002, 48hours) increases nuclear localization of FOXO3a (green). DAPI is shown in blue. Magnification 40. Right, combined inhibition (3 μmol/L PLX4720 t 10 μmol/L LY294002, 48 hours) increases PTEN WM793 BIM mRNA levels to those observed with single BRAF inhibition (3 μmol/L PLX4720, 48 hours) in the PTENt WM35. C, PTEN cells were treated with PLX4720 (3 μmol/L, 48 hours), GDC-0941 (3 μmol/L, 48hours), or a combination of the 2 drugs (3Pt3G) before Annexin-V staining was analyzed by flow cytometry (*, P < 0.05 between the drug combination and each inhibitor alone). D, combined BRAF/PI3K inhibitor treatment blocks the escape of 1205Lu cells (PTEN) from therapy. Spheroids of 1205Lu cells were treated with either PLX4720 alone (3 and 10 μmol/L: data shows 3 mmol/L), LY294002 (10 μmol/L) alone or a combination of the 2 drugs for 72 hours. In other studies, spheroids were treated with drugs for 72 hours and then allowed to recover for 120 hours. Micrograph shows viability staining (green= live cells, red= dead cells). Magnification 10×.

    Cancer Res 2011 71, 2750-2760. Pictilisib (GDC-0941) purchased from Selleck.

    Combination of rapamycin and PI-103 leads to the suppression of AKT phosphorylation (phospho-specific western blot). Mel-Juso and 518A2 cells were treated with GDC-0941 from 0.05–1 μmol/L alone and in combination with rapamycin (50 nmol/L) for 24 hours. Control treatment was with DMSO.

     

     

    J Inves Der 2010 131, 495-503. Pictilisib (GDC-0941) purchased from Selleck.

  • TGF-β induces mTORC2 activation. ( A ) NMuMG cells were treated with TGF-β for the indicated times before lysis and immunoblotting. (B ) NMuMG cells were treated or not with TGF-β for the indicated times, in the presence or absence of SB431542 or LY294002. Cell lysates were subjected to anti-Rictor immunoprecipitation, and the immunoprecipitates were subjected to in vitro kinase assays using kinase-inactive Akt1 as a substrate, before immunoblotting of the kinase reactions, immunoprecipitates and cell lysates. The left panels are from the same gel, without differential exposure. ( C ) NMuMG cells were treated or not with TGF-β or insulin for the indicated times, in the presence or absence of SB431542 or GDC-0941. The kinase activity of mTORC2 was then assessed as in B. The top panels are from the same gel, without differential exposure. (D) NMuMG cells were treated or not with TGF-β for the indicated times, in the presence or absence of SB431542 or LY294002. Cell lysates were subjected to immunoprecipitation using Rictor antibody, and/or immunoblotted.

    J Cell Sci 2012 125(Pt 5), 1259-73. Pictilisib (GDC-0941) purchased from Selleck.

    Effects of LY294002 and GDC-0941 on the high-glucose-induced plasma membrane translocation of DGK δ1. (A, C) HEK293 cells were transfected with pAcGFP-DGKδ1 or pAcGFP-C1 vector. After being glucose-starved for 2.5 h and the subsequent pretreatment with (A) 10 μM LY294002 (Sigma-Aldrich) or (C) 1 μM GDC-0941 (Selleck Chemicals) for 30 min, the cells were incubated with or without high glucose (25 mM) for 5 min. The cells were fixed with 3.7% formaldehyde and observed using confocal laser-scanning microscopy. Scale bar = 10 μm. (B, D) After treatment with (B) LY294002 or (D) GDC-0941, the percentages of cells exhibiting the translocation of AcGFP-tagged DGK δ 1 to the plasma membrane were scored. More than 20 cells ex-pressing AcGFP-tagged DGK δ1 were counted in each experiment. The results are the means ± S.D. of three independent experiments. The statistical significance was deter-mined using Student's t -test (** P < 0.01, *** P < 0.005)

    Biochim Biophys Acta 2012 1823, 2210-6. Pictilisib (GDC-0941) purchased from Selleck.

  • After starved in serum-free medium for 24h, Breast cancer cells incubated with the indicated concentrations of GDC-0941  for 3h,followed by 15-minute  stimulation of 100ng/ml EGF.

     

     

     

    Dr. Zhang of Tianjin Medical University. Pictilisib (GDC-0941) purchased from Selleck.

    We treated all of drugs in T47D which has a PI3KCA H1044R mutation with the concentration shown below for 1 hour and performed western blot analysis using antibodies to phospho-AKT(SERINE 472), and total AKT.

     

     

    Saraswati Sukumar of Johns Hopkins University School of Medicine. Pictilisib (GDC-0941) purchased from Selleck.

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    PI3K pathway signaling in GDC-0941 and MK-2206 treated MCF-7 derivatives with PIK3CA or  AKT1 mutations. Cells were grown in medium containing 5% FBS and treated with vehicle or increasing concentrations of GDC-0941 (0 nM, 50 nM, 100 nM, and 400 nM) or MK-2206 (0 nM, 100 nM, 250 nM, 1000 nM). After 24 hours of drug treatment, lysates were prepared and equal amounts of protein were load ed onto SDS-PAGE gels and blotted with the indicated antibodies.

    Pictilisib (GDC-0941) purchased from Selleck.

Purity & Quality Control

Choose Selective PI3K Inhibitors

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Notes:

2. For more details, such as half maximal inhibitory concentrations (IC50s) and working concentrations of each inhibitor, please click on the link of the inhibitor of interest.
3. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
4. Orange "√" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

Biological Activity

Description Pictilisib (GDC-0941) is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM in cell-free assays, with modest selectivity against p110β (11-fold) and p110γ (25-fold). Phase 2.
Targets
p110α [1]
(Cell-free assay)
p110δ [1]
(Cell-free assay)
p110β [1]
(Cell-free assay)
p110γ [1]
(Cell-free assay)
mTOR [1]
(Cell-free assay)
3 nM 3 nM 33 nM 75 nM 0.58 μM(Ki app)
In vitro

GDC-0941 is equipotent against PI3Kα and PI3Kδ as well as PI3Kα mutants E545-K and H1047-R, displaying modest levels of selectivity against PI3Kβ (10-fold) and PI3Kγ (25-fold), and greater levels of selectivity against members of PI3K class II, III, and IV, including C2β, Vps34, DNA-PK, and mTOR. GDC-0941 potently inhibits the phosphorylation of Akt in U87MG, PC3, and MDA-MB-361 cells with IC50 of 46 nM, 37 nM, and 28 nM, respectively. GDC-0941 inhibits the proliferation of U87MG, A2780, PC3, and MDA-MB-361 cells with IC50 of 0.95 μM, 0.14 μM, 0.28 μM, and 0.72 μM, respectively. [1] GDC-0941 treatment potently inhibits the proliferation of both trastuzumab-sensitive and -insensitive HER2-amplified cells with IC50 of 149-944 nM. GDC-0941 inhibits proliferation of HER2-amplified cells that harbor PIK3CA mutations with IC50 of <500 nM, and effectively inhibits both proliferation and viability of HER2-amplified breast cancer cells that are resistant to trastuzumab due to PTEN loss. [2] GDC-0941 significantly inhibits the growth of HCT116, DLD1 and HT29 cells with GI50 of 1081 nM, 1070 nM and 157 nM, respectively. [3] GDC-0941 inhibits tumor cell proliferation, induces apoptosis and suppresses centroblast population. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Sf9 MWfLbY5ie2ViQYPzZZk> NXW0Xm5TOSCq NVzq[ZZlTE2VTx?= NUXiW2I4UW6qaXLpeIlwdiCxZjDoeY1idiC{ZXPvcYJqdmGwdDDQTVNMKHBzMUDk[Yx1[SCneIDy[ZN{\WRiaX6gV4Y6KGOnbHzzJINw\XiycnXzd4lv\yCyOEXhcJBp[SC5aYToJGlEPTBib3[gNE4xODNizszN NVnDT4tbOTh5NUS2OVQ>
Sf9 NGH6bYVMcW6jc3WgRZN{[Xl? NW\q[mtMOSCq M{jp[mROW09? NILGfG5KdmirYnn0bY9vKG:oIHj1cYFvKHKnY3;tZolv[W62IGDJN2sheDFzMHLleIEhUDFyNEetVkBufXSjboSg[ZhxemW|c3XkJIlvKFOoOTDj[YxteyClb3X4dJJme3OrbnegdFg2[WyyaHGge4l1cCCLQ{WwJI9nKDBwMECzJO69VQ>? MVOxPFc2PDZ3NB?=
Sf9 MWrLbY5ie2ViQYPzZZk> NHPmNHEyKGh? NGLEc45FVVOR MnfWTY5pcWKrdHnvckBw\iCqdX3hckBz\WOxbXLpcoFvfCCSSUPLJJAyOTCkZYThJGU2PDVvSzDteZRidnRiZYjwdoV{e2WmIHnuJHNnQSClZXzsd{Bkd2W6cILld5NqdmdicEi1ZYxxcGFid3n0bEBKSzVyIH;mJFAvODB|IN88US=> MUmxPFc2PDZ3NB?=
Sf9 NXvKVXBnU2mwYYPlJGF{e2G7 M1ezeFEhcA>? MmHtSG1UVw>? NF7JdmVKdmirYnn0bY9vKG:oIHj1cYFvKHKnY3;tZolv[W62IGDJN2sheDFzMHLleIEh\XiycnXzd4VlKGmwIGPmPUBk\WyuczDjc4V5eHKnc4PpcocheDh3YXzwbIEhf2m2aDDJR|UxKG:oIECuNFM{KM7:TR?= NHTEc|AyQDd3NE[1OC=>
Sf9 M{\kfWtqdmG|ZTDBd5NigQ>? MXWxJIg> MUPEUXNQ NWDVS3VuUW6qaXLpeIlwdiCxZjDoeY1idiC{ZXPvcYJqdmGwdDDQTVNMKHBzMUDhcJBp[SCneIDy[ZN{\WRiaX6gV4Y6KGOnbHzzJINw\XiycnXzd4lv\yCyOEXhcJBp[Q>? NGn4ZYcyQDd3NE[1OC=>
MDA-MB-361 M4j3T2Z2dmO2aX;uJGF{e2G7 NWrVV5NqOiCq M1SyRmROW09? NWrXV5l{UW6qaXLpeIlwdiCxZjDBb5QhW2W{NEezJJBpd3OyaH;yfYxifGmxbjDpckBpfW2jbjDNSGEuVUJvM{[xJINmdGy|IIfpeIghWEmNM1PBJGU2PDVvSzDteZRifGmxbjD3bZRpKEmFNUCgc4YhOC5yMkig{txO M{TpR|E5PzV2NkW0
PC3 NHizendHfW6ldHnvckBCe3OjeR?= M1HOZ|IhcA>? NUXjXo9OTE2VTx?= MVjJcohq[mm2aX;uJI9nKEGtdDDT[ZI1PzNicHjvd5Bpd3K7bHH0bY9vKGmwIGDUSW4udnWubDDoeY1idiCSQ{OgZ4VtdHNid3n0bEBKSzVyIH;mJFAvODN5IN88US=> M2q5clE5PzV2NkW0
U87MG M1SyPGZ2dmO2aX;uJGF{e2G7 MY[yJIg> MorwSG1UVw>? NITkTXRKdmirYnn0bY9vKG:oIFHreEBU\XJ2N{OgdIhwe3Cqb4L5cIF1cW:wIHnuJHBVTU5vboXscEBpfW2jbjDVPFdOTyClZXzsd{B4cXSqIFnDOVAhd2ZiMD6wOFYh|ryP MoHwNVg4PTR4NUS=
MDA-MB-361 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1zPSVk3KGh? M{LJS2ROW09? MYjBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2GQT3NRk0{PjFiY3XscJMhf2m2aDDQTWs{S0FiRUW0OU1MKG23dHH0bY9vKHerdHigTWM2OCCxZjCwMlczKM7:TR?= NILUNZQyQDd3NE[1OC=>
A2780 MnnLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXS5OkBp NILYW5FFVVOR NVfJUHNISW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDBNlc5OCClZXzsd{B4cXSqIGDJT|NESSCjbnSgVHRGViCvdYTheIlwdiC5aYToJGlEPTBib3[gNE4yPCEQvF2= NHH0doYyQDd3NE[1OC=>
PC3 M2fPdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3PkZlk3KGh? NV34WGhNTE2VTx?= NFG0PJNKSzVyPUCuNlgh|ryP NGDrRXgyQDd3NE[1OC=>
U87MG NUXZXoRIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYThXpNOQTZiaB?= NU\3SJVjTE2VTx?= NVTncmhGUUN3ME2wMlk2KM7:TR?= M1rQR|E5PzV2NkW0
Sf9 MVnLbY5ie2ViQYPzZZk> NF;qemQ{OCCvaX6= M1TuUmROW09? NITq[HdKdmirYnn0bY9vKG:oIHj1cYFvKFCLM1vnZY1u[SCneIDy[ZN{\WRiYYPz[ZN{\WRiYYOgZY1wfW62IH;mJGFVWCClb37zeY1m\CC5aYToJGlEPTBib3[gNE4xPDJizszN MUKyNlU1QDN2Mh?=
RAW 264.7 NUi1WHc3U2mwYYPlJGF{e2G7 NHHTVng6OCCvaX6= NWXzNVI1TE2VTx?= MnPSTY5pcWKrdHnvckBw\iCqdX3hckBRUTONZ3HtcYEh\XiycnXzd4VlKGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4YhSUuWIIDoc5NxcG:{eXzheIlwdiC5aYToJGlEPTBib3[gNE4zQThizszN MX:yNlU1QDN2Mh?=
Sf9 NVT3enI3U2mwYYPlJGF{e2G7 NVTwR4tkOSCq NFLLNY5KdmirYnn0bY9vKG:oIFfTWE1nfXOnZDDoeY1idiC{ZXPvcYJqdmGwdDDQTVNM[mW2YTDlfJBz\XO|ZXSgbY4h[mGldXzveolzfXNiaX7m[YN1\WRiU1[5JINmdGy|IIfpeIghUUN3MDDv[kAxNjBzNzFOwG0> M4Lt[VI{PTRyNkS1
Sf9 Ml3kT4lv[XOnIFHzd4F6 M2HjblEhcA>? M17ibmlvcGmkaYTpc44hd2ZiR2PUMYZ2e2WmIHj1cYFvKHKnY3;tZolv[W62IGDJN2tl\Wy2YTDlfJBz\XO|ZXS= MlzGNlM2PDB4NEW=
Sf9 MY\LbY5ie2ViQYPzZZk> MnO4NUBp NWO3UFhZUW6qaXLpeIlwdiCxZjDHV3Qu\nW|ZXSgbJVu[W5icnXjc41jcW6jboSgVGk{U2ejbX3hJIV5eHKnc4Pl[C=> NWDwdoRZOjN3NEC2OFU>
Sf9 NYLnbYRuU2mwYYPlJGF{e2G7 MlPDNUBp MXfJcohq[mm2aX;uJI9nKEeVVD3meZNm\CCqdX3hckBz\WOxbXLpcoFvfCCSSUPLZYxxcGFiZYjwdoV{e2Wm MnfpNlM2PDB4NEW=
SKOV3 NVrGTHp5U2mwYYPlJGF{e2G7 MUCxJO69VQ>? MnfsNUBp MVrEUXNQ NV;mRWQzUW6qaXLpeIlwdiCxZjDQTVNM[WyyaHGgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDBb5QhW2W{NEezJJBpd3OyaH;yfYxifGmxbh?= NVO2NmI5OjN|NkCzOFg>
MCF7 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\IXXdvOSEQvF2= MV:5OkBp M3rWRmROW09? NETJellIUTVyPUCuNFcxOiEQvF2= MnKwNlM{PjB|NEi=
SKOV3 M1XSS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnLVNUDPxE1? NETt[2g6PiCq NGGzRWtFVVOR M3m2emdKPTB;MD6xOFc3KM7:TR?= M2j2TVI{OzZyM{S4
PC3 NWHzZpMyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEnPdo04OiCq M1vVSmROW09? M174TmlEPTB;MD6yPEDPxE1? MnHzNlE6QDF5MUS=
MCF7.1 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYrEWmNjPzJiaB?= M{TjOWROW09? NWW1Z|FLSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNR2Y4NjFiY3XscJMh\XiycnXzd4lv\yCKRWKyJIdmdmVid3n0bEBKSzVyIH;mJFAvOjhizszN MkmxNlE6QDF5MUS=
MCF7-neo/Her2 NV\kWJNNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1TxV|czKGh? NGTGRYlFVVOR NVG4R2Q4UUN3ME2wMlI6KM7:TR?= NULV[2VEOjN4NkK5NFM>
MCF7-neo/Her2 M2XYb2tqdmG|ZTDBd5NigQ>? M3LPW2lvcGmkaYTpc44hd2ZiUFmzT4FteGijIHHzd4V{e2WmIHHzJJJm\HWldHnvckBw\iCDS2SgdIhwe3Cqb4L5cIF1cW:wIHH0JHM1PzNid3n0bEBKSzVyIH;mJFAvODB5IN88US=> NHvhfXkzOzZ4MkmwNy=>
PC3 NGHqWJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVW1S4NQPzJiaB?= M3LXfWROW09? MX7FR|UxRTBwM{Sg{txO NWP0Z3M1OjF7OEW2N|k>
MCF7.1 MlnvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3fwSVczKGh? M4P1U2ROW09? NH;BWFJCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3DSlcvOSClZXzsd{BmgHC{ZYPzbY5oKFCLM1vhcJBp[SCvdYThcpQhf2m2aDDFR|UxKG:oIECuN|kh|ryP MVmyNVk5PTZ|OR?=
PC3 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NETIbpQ4OiCq MkLPSG1UVw>? NFj5R2FCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGDDN{Bk\WyuczDk[YZq[2mnboSgbY4hWFSHTjD3bZRpKEmFNUCgc4YhOC5|OTFOwG0> NHzHeXYzODB3ME[2PS=>
MCF7.1 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;uSoM4OiCq MUXEUXNQ MUnBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2FRkeuNUBk\WyuczDlfJBz\XO|aX7nJHBKO0ujbIDoZUBufXSjboSge4l1cCCLQ{WwJI9nKDBwM{Sg{txO M4fadlIxODVyNk[5
MCF7.1 MlXmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWC3NkBp MVjFR|UxRTBwN{Kg{txO M37TSVIxOzR4NkW2
NCI-H1975 MnPyR5l1d3SxeHnjJGF{e2G7 MYi3NkBp MofKTWM2OD1yLkK3JO69VQ>? M4PNV|I{ODV7NUS1
H460 NVnSSmJLS3m2b4TvfIlkKEG|c3H5 NITLenc4OiCq NEPzTXRKSzVyPUCuPFch|ryP M4jTRVI{ODV7NUS1
HT-29 MkjWR5l1d3SxeHnjJGF{e2G7 M4DF[lczKGh? MYnJR|UxRTBwNk[g{txO MWiyN|A2QTV2NR?=
HepG2 NI\6cW9EgXSxdH;4bYMhSXO|YYm= M3H4Z|czKGh? MVTJR|UxRTFizszN NETkZnUzOzB3OUW0OS=>
SGC7901 M{jSeWN6fG:2b4jpZ{BCe3OjeR?= NVnjTYNkPzJiaB?= NUm3Voh5UUN3ME2xMlgh|ryP NFLoVpAzOzB3OUW0OS=>
NCI-H226 M3XlVGN6fG:2b4jpZ{BCe3OjeR?= M{XQTVczKGh? NXjYW5hRUUN3ME2yMlkh|ryP MXKyN|A2QTV2NR?=
A549 M1LINWN6fG:2b4jpZ{BCe3OjeR?= MVS3NkBp M{CxRWlEPTB;Nj65JO69VQ>? NE\iRYYzOzB3OUW0OS=>
U87MG MXjDfZRwfG:6aXOgRZN{[Xl? NFLXNGE4OiCq M1HkWWlEPTB;Nz63O{DPxE1? M2X4dlI{ODV7NUS1
HBC4 M2m0N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWTabJlydG:pR1m1NF0uPi5yMzDN M174WlIzOzN4MkS2
BSY1 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoHzcI9oT0l3ME2tOk46OCCP M13WdFIzOzN4MkS2
HBC5 NH\LTI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NETkWVRtd2eJSUWwQU03NjZyIF2= MlTzNlI{OzZ{NE[=
MCF7 NWiwZ3RkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV3Fe41bdG:pR1m1NF0uPy5|MzDN MkjDNlI{OzZ{NE[=
MDA-MB-231 MnLmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPsc4dIUTVyPT21MlQ3KE1? M1u3[VIzOzN4MkS2
U251 NEfPSWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2LmNoxw\0eLNUC9MVUvPTBiTR?= NXnqTGJVOjJ|M{[yOFY>
SF268 Ml;WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MorwcI9oT0l3ME2tOU4{QSCP M2ruVlIzOzN4MkS2
SF295 MlzhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGD1bWNtd2eJSUWwQU03NjN5IF2= NYGy[IlKOjJ|M{[yOFY>
SF539 M2jneWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTacI9oT0l3ME2tOk42OCCP NVHvSZV7OjJ|M{[yOFY>
SNB75 NEHKd4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlzXcI9oT0l3ME2tO{4yOCCP NED3PFIzOjN|NkK0Oi=>
SNB78 MnzNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHsc4dIUTVyPT22MlUzKE1? M2i2[lIzOzN4MkS2
HCC2998 Mmj1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGXWNmJtd2eJSUWwQU03NjJ7IF2= NFrsO2czOjN|NkK0Oi=>
KM12 NEfkN29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjsc4dIUTVyPT21Mlc3KE1? MkjBNlI{OzZ{NE[=
HT-29 Mlz1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWHJfop1dG:pR1m1NF0uPi5|MDDN M1SyXlIzOzN4MkS2
HCT15 MnTSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoX0cI9oT0l3ME2tOk4yOiCP MWGyNlM{PjJ2Nh?=
HCT116 MmjnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYTsc4dIUTVyPT21Mlg4KE1? MkHxNlI{OzZ{NE[=
NCI-H23 NFLSdWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3sc4dIUTVyPT21Mlc{KE1? NELBbnkzOjN|NkK0Oi=>
NCI-H226 NYmw[nJKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlnLcI9oT0l3ME2tOk4zOSCP NYXJXo9TOjJ|M{[yOFY>
NCI-H522 MmixS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnsc4dIUTVyPT22MlU5KE1? NE\6[WozOjN|NkK0Oi=>
NCI-H483 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGT6bIptd2eJSUWwQU03NjV4IF2= MX6yNlM{PjJ2Nh?=
A549 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIfEXpFtd2eJSUWwQU03NjF3IF2= MnLGNlI{OzZ{NE[=
DMS273 MlzQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEDaVWxtd2eJSUWwQU03NjR|IF2= NIDDZoYzOjN|NkK0Oi=>
DMS114 M1HMPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGHkOXltd2eJSUWwQU02Njl{IF2= MlXPNlI{OzZ{NE[=
LOXIMVI M3XOPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHHuNFBtd2eJSUWwQU03NjJ7IF2= NV;mNJlROjJ|M{[yOFY>
OVCAR3 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGGxVYJtd2eJSUWwQU03NjdzIF2= NUjBU2lzOjJ|M{[yOFY>
OVCAR4 NXrEfGV7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHHXdZptd2eJSUWwQU02Njd4IF2= NEL5W2IzOjN|NkK0Oi=>
OVCAR5 M2TNcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVnZdJZVdG:pR1m1NF0uPi5{NjDN MVGyNlM{PjJ2Nh?=
OVCAR8 M37NUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrsc4dIUTVyPT21Mlc{KE1? MX6yNlM{PjJ2Nh?=
SKOV3 MnfHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlK5cI9oT0l3ME2tOk42OiCP MYiyNlM{PjJ2Nh?=
RXF631L Mn60S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1HiSYxw\0eLNUC9MVYvQDhiTR?= M1zrSVIzOzN4MkS2
ACHN NH76PG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEDlN4Ntd2eJSUWwQU03NjB5IF2= MX[yNlM{PjJ2Nh?=
St-4 NYHW[YhXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnHocI9oT0l3ME2tOU42PiCP NF[5eG4zOjN|NkK0Oi=>
MKN1 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\DepZtd2eJSUWwQU04NjB6IF2= M{LVR|IzOzN4MkS2
MKN7 Mki3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1zBT4xw\0eLNUC9MVYvPTBiTR?= NFL5NYkzOjN|NkK0Oi=>
MKN28 M{XsVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYfrN2tFdG:pR1m1NF0uPS53MjDN MoraNlI{OzZ{NE[=
MKN45 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{jKW4xw\0eLNUC9MVYvPTViTR?= MoX5NlI{OzZ{NE[=
MKN74 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHzofYxtd2eJSUWwQU03NjB{IF2= MmnvNlI{OzZ{NE[=
DU145 MoXZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjsc4dIUTVyPT21Mlg2KE1? NXGz[nJNOjJ|M{[yOFY>
PC3 NI\rfIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX7lfVRVdG:pR1m1NF0uPi54NjDN M4fveVIzOzN4MkS2
ES5 NVLTc3VqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfSZ4JKSzVyPUWwMlIyKG6P M{\yS3NCVkeHUh?=
HH M1PyWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTFzMT6wPEBvVQ>? NEHlemlUSU6JRWK=
MHH-PREB-1 MoK0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkXoTWM2OD1zMUSuN{BvVQ>? M1PzeXNCVkeHUh?=
NCI-H1770 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTF{Mz64OkBvVQ>? M3i4XHNCVkeHUh?=
HuO9 MlG4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLJR|UxRTJyNj6wNkBvVQ>? NY\ZSI5pW0GQR1XS
HAL-01 NILTc3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3rS[2lEPTB;MkC2Mlc{KG6P M{DUT3NCVkeHUh?=
NOS-1 MmTGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\ETmlEPTB;MkGxMlgzKG6P MnrhV2FPT0WU
HGC-27 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\JZWlEPTB;MkGyMlU4KG6P NXjuPYFmW0GQR1XS
NB69 MmnyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4PpSWlEPTB;MkS1MlI4KG6P NEXNRlZUSU6JRWK=
RS4-11 NIfpOo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2judmlEPTB;Mk[xMlc3KG6P M{\W[3NCVkeHUh?=
DOK M4TSSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRTNyMT63JI5O NIPafJRUSU6JRWK=
LB2241-RCC NFnt[oRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\5VGlEPTB;M{CzMlg1KG6P M2\mRXNCVkeHUh?=
NCI-H1623 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUDaOnY5UUN3ME2zNFQvODhibl2= M4n3WXNCVkeHUh?=
YH-13 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4C0NGlEPTB;M{C0MlMzKG6P MYTTRW5ITVJ?
BPH-1 MlTGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGr3dHNKSzVyPUOxOEBvVQ>? M1vaN3NCVkeHUh?=
AN3-CA MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYS3O5JmUUN3ME2zOFAvOzdibl2= MoD0V2FPT0WU
ES7 MmfLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkTJTWM2OD1|NEGuPVkhdk1? NH3mPWFUSU6JRWK=
MDA-MB-175-VII MnnSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTN3Mj65NkBvVQ>? MYHTRW5ITVJ?
GAMG MlfKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\GZmlEPTB;M{ewMlg2KG6P MmfvV2FPT0WU
CHL-1 NHnTTnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MojWTWM2OD1|N{iuOlUhdk1? MoO3V2FPT0WU
NB7 NHLSdoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHLcGtHUUN3ME2zPFkvQDNibl2= NFnBd4NUSU6JRWK=
MFE-280 M2qzemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF;ybnNKSzVyPUSxPE4zKG6P M1yxVnNCVkeHUh?=
HL-60 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTR{NT63OUBvVQ>? MWDTRW5ITVJ?
GCIY NW\yU45MT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3ryPWlEPTB;NEOzMlghdk1? NVrtZmtZW0GQR1XS
MDA-MB-361 NV2xbYtST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3SzUmlEPTB;NEO5MlE{KG6P MkjmV2FPT0WU
LXF-289 NXXKb|VKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFPER4VKSzVyPUS0PE4zPyCwTR?= NHryZllUSU6JRWK=
NBsusSR M1jEVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml\HTWM2OD12OEiuPFUhdk1? NV34c5VuW0GQR1XS
KU-19-19 MnLJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWrJR|UxRTVzNj6wO{BvVQ>? M3i1bHNCVkeHUh?=
A204 MnjPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXm1RmpWUUN3ME21NlIvOzNibl2= MVjTRW5ITVJ?
LB1047-RCC MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW[0ZWk1UUN3ME21NlIvQTNibl2= NFzqdohUSU6JRWK=
COLO-684 NGPqNXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX7Veld6UUN3ME21NlMvOTFibl2= NYH5Vm4xW0GQR1XS
PA-1 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTLTWM2OD13M{KuOFEhdk1? MmHVV2FPT0WU
MG-63 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4CwfmlEPTB;NUSxMlEyKG6P M3XNVXNCVkeHUh?=
BHT-101 M{XLTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV;POJRjUUN3ME21OFQvQTRibl2= NH:1R2pUSU6JRWK=
NKM-1 NHrOSGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTV7Mz6wPUBvVQ>? NUPPSmM4W0GQR1XS
T47D MnHLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4XuVGlEPTB;NUm3MlU3KG6P M33oVnNCVkeHUh?=
MOLT-4 NI\NZXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTZ{Mz62NkBvVQ>? Mn3OV2FPT0WU
IGROV-1 NWTPSmxRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnnGTWM2OD14M{SuN|Ehdk1? NW\Fb4dNW0GQR1XS
ES4 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlXwTWM2OD14M{muOVQhdk1? NITuTlNUSU6JRWK=
HuO-3N1 NYrqZXIyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoPvTWM2OD14NEKuN|ghdk1? NYjKfncyW0GQR1XS
NEC8 Ml;6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkPXTWM2OD14NUOuOVchdk1? NIP3cGNUSU6JRWK=
HO-1-N-1 MoXlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmDRTWM2OD14NUmuNVchdk1? MmrVV2FPT0WU
EPCL-272H MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{HzWmlEPTB;Nki3MlIyKG6P Mlq1V2FPT0WU
D-263MG MnTMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\6TWM2OD15MUiuNUBvVQ>? NFnGUXVUSU6JRWK=
MV-4-11 NWL1R21ST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYLsO3ZQUUN3ME23NlQvOzFibl2= MV3TRW5ITVJ?
SK-NEP-1 NH\zV4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFrWfFlKSzVyPUeyOU46PCCwTR?= MmLsV2FPT0WU
SW872 M3\wWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1rjOmlEPTB;N{K3Mlg6KG6P MkTMV2FPT0WU
P30-OHK Mn3hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLDTWM2OD15M{CuO|Ehdk1? MnrCV2FPT0WU
OMC-1 MoX6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVjxT2hKUUN3ME23OVEvODlibl2= MVXTRW5ITVJ?
LoVo NHL0XZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHiweIVKSzVyPUe3O{46KG6P Ml\pV2FPT0WU
LNCaP-Clone-FGC MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{fLfmlEPTB;N{m2MlM1KG6P MoXSV2FPT0WU
L-363 NVfnTYg4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn22TWM2OD15OUiuOFIhdk1? MW\TRW5ITVJ?
ES8 NILlU3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRThzMD61NkBvVQ>? NI\abnFUSU6JRWK=
697 MoLjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFvo[YVKSzVyPUizNU42PSCwTR?= NXzPfmpkW0GQR1XS
HSC-3 NGjq[HZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mmj2TWM2OD16M{muOVQhdk1? M2HETXNCVkeHUh?=
H4 NVjWR2h[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MW\JR|UxRTh3MD64OUBvVQ>? NIX5foVUSU6JRWK=
QIMR-WIL MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTh4NT6yJI5O MmHYV2FPT0WU
OAW-42 NGf5coxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTlNplKSzVyPUi3Nk4yQSCwTR?= NITjWFRUSU6JRWK=
MCF7 NIHWfIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXjbZZKSzVyPUi5PE42QSCwTR?= MmLCV2FPT0WU
SCC-25 NVLSclRlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfJR|UxRTlzND6xPUBvVQ>? NVPP[nM4W0GQR1XS
NCI-H1563 M4f3XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmDyTWM2OD17MUWuPVkhdk1? M3\QOXNCVkeHUh?=
OVCAR-5 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTl2MD6xO{BvVQ>? NYPYTXo5W0GQR1XS
HDLM-2 NFu0fGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn7JTWM2OD17NEmuNkBvVQ>? M{XpRnNCVkeHUh?=
NB5 Mn3lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVjJR|UxRTl3Nj62JI5O MW\TRW5ITVJ?
NCI-H292 NFWzUJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTl5ND6zNkBvVQ>? M3y4PXNCVkeHUh?=
A101D M1Hrd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXHMcGhFUUN3ME25PVAvOTlibl2= NWjHPFVEW0GQR1XS
NCI-H1648 MkSyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2rUSWlEPTB;OUm4MlUyKG6P NXTBOndnW0GQR1XS
EKVX NFPpWlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn7KTWM2OD1zLkCxNlkh|ryP MYjTRW5ITVJ?
SW1710 MmLYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\1XGlEPTB;MT6wOFI{OyEQvF2= Ml;iV2FPT0WU
WM-115 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH70XJhKSzVyPUGuNFY3PTZizszN M4nPVnNCVkeHUh?=
CAL-54 M2rqUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVfEe4M5UUN3ME2xMlA4ODhzIN88US=> MlHBV2FPT0WU
TGBC24TKB MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTFwMEiwOFUh|ryP M1i3cnNCVkeHUh?=
NCI-H520 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTFwMEi5Olch|ryP NX6xWZBJW0GQR1XS
D-423MG M{\uZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4LBRWlEPTB;MT6wPVk3OiEQvF2= M2GyeHNCVkeHUh?=
BFTC-905 Mn;2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3fOUmlEPTB;MT6xN|Q1QSEQvF2= Ml32V2FPT0WU
HT MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTFwMUO0O|gh|ryP NHTxcVBUSU6JRWK=
CTB-1 MoezS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTFwMUSyPVMh|ryP NXzS[HhSW0GQR1XS
Hs-578-T NYDhV25HT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{fN[WlEPTB;MT6xPVU3PSEQvF2= MmO2V2FPT0WU
HuH-7 M2XFUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWH5V4oyUUN3ME2xMlIxQTR7IN88US=> M33QfHNCVkeHUh?=
LB996-RCC NXLEfY57T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mmi5TWM2OD1zLkKyNVc4KM7:TR?= NWX6bZFZW0GQR1XS
KYSE-270 M{LGWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGTmZVNKSzVyPUGuNlk4OzRizszN NIrrOldUSU6JRWK=
A4-Fuk NXi2eI9TT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGK5fnZKSzVyPUGuNlk6QTNizszN MV7TRW5ITVJ?
A498 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTFwM{C0O|Qh|ryP MlHhV2FPT0WU
SK-MEL-1 NHvxNJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zHWmlEPTB;MT6zNFY4QSEQvF2= M3LvSXNCVkeHUh?=
AU565 NHLEbohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlT0TWM2OD1zLkOxPFY{KM7:TR?= MmfKV2FPT0WU
Saos-2 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\selBTUUN3ME2xMlM{OjB3IN88US=> M1H2TnNCVkeHUh?=
A549 NHO4d3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHnCdXNKSzVyPUGuN|k6PyEQvF2= NFvs[2FUSU6JRWK=
BFTC-909 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF7yRo9KSzVyPUGuOFM{ODVizszN MXzTRW5ITVJ?
MDA-MB-415 NXvKUJVyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTFwNEi2PVIh|ryP MVXTRW5ITVJ?
639-V MmjjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MknXTWM2OD1zLkWwNlQ2KM7:TR?= NGXo[mFUSU6JRWK=
A704 NE\sUXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTFwNUC3PFUh|ryP NVnMNoQ4W0GQR1XS
PANC-03-27 M1XRPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWT6S5pDUUN3ME2xMlUyPDB6IN88US=> MUTTRW5ITVJ?
SK-MEL-28 NFn2XJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTFwNU[wPFUh|ryP MnGyV2FPT0WU
Ramos-2G6-4C10 NF7uWZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkS3TWM2OD1zLk[wO|Q3KM7:TR?= NUiyRY92W0GQR1XS
HuP-T4 MojxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYW1OZpkUUN3ME2xMlYxPzd6IN88US=> MUTTRW5ITVJ?
VA-ES-BJ NVLZS3BIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmTpTWM2OD1zLk[xNlch|ryP NEC5NoRUSU6JRWK=
EFM-19 NYPiZ2JzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTFwNkG4NUDPxE1? MnThV2FPT0WU
G-401 NFXzRoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkjvTWM2OD1zLk[yNVY1KM7:TR?= MknsV2FPT0WU
D-566MG MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4DDTmlEPTB;MT62NlU{KM7:TR?= M4fnfXNCVkeHUh?=
JVM-3 NF;mTnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYHlWZdyUUN3ME2xMlY1QDd3IN88US=> MXHTRW5ITVJ?
TK10 M4PNSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkXPTWM2OD1zLk[3NFg{KM7:TR?= MlvPV2FPT0WU
BT-20 NGTO[XpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlu3TWM2OD1zLk[4PVAzKM7:TR?= Mmm1V2FPT0WU
EGI-1 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTFwOES3NFEh|ryP MYTTRW5ITVJ?
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RKO MnrkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLJUpFVUUN3ME2yOk44PjN{IN88US=> NVL2eoZmW0GQR1XS
CAL-85-1 M1LoV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX;Ge3lOUUN3ME2yO{4zOTF6IN88US=> NXG5R4JFW0GQR1XS
CAL-120 M2[zemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\wTWM2OD1{Nz62PVE1KM7:TR?= M1rpZnNCVkeHUh?=
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NCI-H1395 MmDHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2\xO2lEPTB;MkeuO|g{OyEQvF2= M{i0b3NCVkeHUh?=
KYSE-450 M3nM[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mom4TWM2OD1{Nz65PFYzKM7:TR?= M2O1c3NCVkeHUh?=
S-117 M{GyZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoftTWM2OD1{OT6zPFU4KM7:TR?= MlmzV2FPT0WU
SW13 MmPYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTJ7Lki1NVkh|ryP MUXTRW5ITVJ?
ES3 NVK5bZo1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYP1RmdOUUN3ME2zNE4{PzN|IN88US=> NH7BT|lUSU6JRWK=
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NCI-H1693 NWnHNm5UT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUeyN4ppUUN3ME2zNE42QTR{IN88US=> NInJfWNUSU6JRWK=
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ALL-PO NFu5cZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHPH[mFKSzVyPUOxMlg1OjhizszN NFPtclhUSU6JRWK=
NCI-H661 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTN{LkC2NlMh|ryP NIDVNINUSU6JRWK=
NCI-H2347 M3nIZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTN{LkS4N|ch|ryP NHH2VnRUSU6JRWK=
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COLO-829 Mlm0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI\JT4VKSzVyPUOzMlM1PjdizszN NVfHOHlsW0GQR1XS
GOTO M1XK[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1z2dGlEPTB;M{OuOVI2QCEQvF2= NEnMfFVUSU6JRWK=
YAPC MmrpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGDtW|VKSzVyPUOzMlgyPTlizszN M3jrW3NCVkeHUh?=
LCLC-103H M{XUfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3L1cWlEPTB;M{SuNVYzPCEQvF2= M{nFbHNCVkeHUh?=
SiHa MnzlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MorETWM2OD1|ND6zPFE4KM7:TR?= MVzTRW5ITVJ?
LK-2 NXjBempST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH3t[plKSzVyPUO0MlU4ODhizszN M33LeXNCVkeHUh?=
KP-N-YS M{fNNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYPJR|UxRTN2LkeyNFIh|ryP NInze3NUSU6JRWK=
NCI-SNU-1 NEDGOZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4jOeGlEPTB;M{WuNVc6KM7:TR?= MV;TRW5ITVJ?
KNS-81-FD MlrMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1;IUmlEPTB;M{WuOlY{KM7:TR?= MorXV2FPT0WU
SCC-9 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;hR|RVUUN3ME2zOk44OTR4IN88US=> NVLRSo1CW0GQR1XS
SH-4 M2XVeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1fHZmlEPTB;M{[uO|Mh|ryP NGLZRo5USU6JRWK=
HCC-1954 NF[zPJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlPMTWM2OD1|Nz6yO|I6KM7:TR?= MonqV2FPT0WU
BALL-1 NFXiVIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYL5coJxUUN3ME2zO{42OzF4IN88US=> MmS4V2FPT0WU
BE-13 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTN5LkewNVgh|ryP M4Lq[XNCVkeHUh?=
COLO-678 MnzNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1nieGlEPTB;M{euPVQ{PyEQvF2= Mki0V2FPT0WU
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CAMA-1 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTN6Lkm2PVEh|ryP NHzPN41USU6JRWK=
C2BBe1 M2DidGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4HQcWlEPTB;M{muPFE5KM7:TR?= NXvtT5FqW0GQR1XS
A3-KAW MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYe2TnV4UUN3ME20NE4{PjZzIN88US=> NX:zcnRmW0GQR1XS
SK-MEL-24 Mn64S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3j3d2lEPTB;NECuOVk{OSEQvF2= MX;TRW5ITVJ?
KYSE-140 MlHXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTRyLkexOlUh|ryP M3nXPXNCVkeHUh?=
MOLT-16 MkXVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJR|UxRTRzLkG1N|Yh|ryP NHX4VlRUSU6JRWK=
CFPAC-1 NUi0bmNpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEn5PWpKSzVyPUSyMlUzOTFizszN NULZSJVHW0GQR1XS
NB14 MlLJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2CxZ2lEPTB;NEKuO|AzPyEQvF2= MXPTRW5ITVJ?
COLO-792 Mm\QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHJR|UxRTR{Lki5OlEh|ryP NXLYPGFSW0GQR1XS
RH-1 M4j2S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{DLS2lEPTB;NEOuOFg{PiEQvF2= NHjBW5VUSU6JRWK=
NCI-H522 Mn35S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXPaPGJ5UUN3ME20OE4{PTZ6IN88US=> MV;TRW5ITVJ?
Ca-Ski NHiyU49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH7LfnhKSzVyPUS0MlgyOTRizszN M2jJUXNCVkeHUh?=
KGN NV;JfYVDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnHGTWM2OD12OD6zNFY{KM7:TR?= NILx[3FUSU6JRWK=
UACC-62 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEHneYVKSzVyPUS4MlQxPzJizszN MlXZV2FPT0WU
NCI-H358 NGeyUJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTR7LkOwNVgh|ryP NFn4Z2JUSU6JRWK=
LS-411N NXfFNllXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mnz3TWM2OD12OT6zNVE5KM7:TR?= NH\2XpBUSU6JRWK=
IST-MES1 NH\RfYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkPhTWM2OD12OT61OlI2KM7:TR?= NFTOWVFUSU6JRWK=

... Click to View More Cell Line Experimental Data

In vivo Administration of GDC-0941 at 75 mg/kg/day displays significant inhibitory effect against established human U87MG glioblastoma xenografts in female NCr athymic mice, with tumor growth inhibition of 83%. [1] Oral administration of GDC-0941 at 150 mg/kg/day inhibits the growth of HER2-amplified, trastuzumab-resistant MDA-MB-361.1 xenografts in mice, and significantly delays the tumor progression, in association with potent induced apoptosis in tumors. [2] GDC-0941 (75 mg/kg/day) treatment for 2 weeks induces ~40% reduction in tumor volume of spontaneous B-cell follicular lymphomas developed in PTEN+/-LKB1+/hypo mice, accompanied by ablation of phosphorylation of Akt, S6K and SGK (serum and glucocorticoid protein kinase) protein kinases. [4]

Protocol

Kinase Assay
+ Expand

Scintillation proximity assay:

Recombinant human PI3Kα, PI3Kβ, and PI3Kδ are coexpressed in a Sf9 baculovirus system with the p85α regulatory subunit and purified as GST-fusion proteins using affinity chromatography on glutathione-sepharose. Recombinant human PI3Kγ is expressed as monomeric GST-fusions and purified similarly. GDC-0941 is dissolved in DMSO and added to 20 mM Tris-HCl (pH 7.5) containing 200 μg yttrium silicate (Ysi) polylysine SPA beads, 4 mM MgCl2, 1 mM dithiothreitol (DTT), 1 μM ATP, 0.125 μCi [γ-33P]-ATP, and 4% (v/v) DMSO in a total volume of 50 μL. The recombinant GST-fusion of PI3Kα (5 ng), PI3Kβ (5 ng), PI3Kδ (5 ng), or PI3Kγ (5 ng) is added to the assay mixture to initiate the kinase reaction. After incubation for 1 hour at room temperature, the kinase reaction is terminated with 150 μL PBS. The mixture is then centrifuged for 2 minutes at 2000 rpm and read using a Wallac Microbeta counter. The reported IC50 values are calculated using a sigmoidal, dose-response curve fit in MDL Assay Explorer.
Cell Research
+ Expand
  • Cell lines: SKBR-3, BT474-M1, AU-565, HCC-1419, ZR75-30, KPL-4, JIMT-1, BT474-EEI, HCC-1954, MCF-7, CALU-3, SKOV-3, and MKN-7 cells
  • Concentrations: Dissolved in DMSO, final concentrations ~10 μM
  • Incubation Time: 48 and 72 hours
  • Method: Cells are exposed to various concentrations of GDC-0941 for 48, and 72 hours. Proliferation/viability of cells is detected by using the CellTiter-Glo Luminescent Cell Viability Assay. The pAkt (Ser473), cleaved caspase-3, and cleaved PARP are analyzed by western blot. The Caspase-Glo 3/7 assay and the Cell Death Detection ELISAplus assay are used to detect caspase 3/7 activity, and apoptosis, respectively.
    (Only for Reference)
Animal Research
+ Expand
  • Animal Models: NCR nude mice implanted with MDA-MB-361.1 cells, and SCID, C.B-17/IcrHsd-Prkdcscid mice implanted subcutaneously with BT474-M1 cells
  • Formulation: Dissolved in 10% DMSO, 5% Tween 20, 85% water
  • Dosages: ~150 mg/kg/day
  • Administration: Oral gavage
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 44 mg/mL (85.66 mM)
Water <1 mg/mL
Ethanol <1 mg/mL
In vivo 2% DMSO+30% PEG 300+5% Tween 80+ddH2O 5mg/mL

* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 513.64
Formula

C23H27N7O3S2

CAS No. 957054-30-7
Storage powder
in solvent
Synonyms RG7321

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
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Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

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To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

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Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02092831 Completed Healthy Volunteer Genentech, Inc. April 2014 Phase 1
NCT01740336 Active, not recruiting Breast Cancer Genentech, Inc. February 2013 Phase 2
NCT01493843 Completed Non-Squamous Non-Small Cell Lung Cancer Genentech, Inc. January 2012 Phase 2
NCT01437566 Completed Breast Cancer Genentech, Inc. October 2011 Phase 2
NCT01474668 Completed Healthy Volunteer Genentech, Inc. October 2011 Phase 1
NCT01240226 Completed Healthy Volunteer Genentech, Inc. November 2010 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID