Pictilisib (GDC-0941)

Catalog No.S1065 Synonyms: RG7321

Pictilisib (GDC-0941) Chemical Structure

Molecular Weight(MW): 513.64

Pictilisib (GDC-0941) is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM in cell-free assays, with modest selectivity against p110β (11-fold) and p110γ (25-fold). Phase 2.

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Cited by 59 Publications

9 Customer Reviews

  • Clonogenic assays of TNBC cell lines grown continuously in increasing concentrations of palbociclib, divided by gene expression subtypes: LAR, luminal androgen receptor; MSL, mesenchymal stem-like; MES, mesenchymal and basal-like. All cell lines are RB1 wild-type except RB1 mutant BT549.

    Clin Cancer Res, 2017, 23(18):5561-5572. Pictilisib (GDC-0941) purchased from Selleck.

    Dual PI3K/BRAF inhibition upregulates BIM and enhances apoptosis in PTEN cells. A, left, Western blot of 1205Lu cells treated with PLX4720 (3 μmol/L, 48 hours), the PI3K inhibitor GDC-0941 (3 μmol/L, 48 hours), or both drugs in combination (PtG); right, immunofluorescence staining of BIM (green) and DAPI (blue) in PTEN cells following PLX4720 treatment (3 μmol/L, 48 hours), the PI3K inhibitor LY294002 (10 μmol/L, 48 hours), or both drugs in combination (PLXtLY). B, left, immunofluorescence staining of PTEN 1205Lu following combined inhibition (3 μmol/L PLX4720 t 10 μmol/L LY294002, 48hours) increases nuclear localization of FOXO3a (green). DAPI is shown in blue. Magnification 40. Right, combined inhibition (3 μmol/L PLX4720 t 10 μmol/L LY294002, 48 hours) increases PTEN WM793 BIM mRNA levels to those observed with single BRAF inhibition (3 μmol/L PLX4720, 48 hours) in the PTENt WM35. C, PTEN cells were treated with PLX4720 (3 μmol/L, 48 hours), GDC-0941 (3 μmol/L, 48hours), or a combination of the 2 drugs (3Pt3G) before Annexin-V staining was analyzed by flow cytometry (*, P < 0.05 between the drug combination and each inhibitor alone). D, combined BRAF/PI3K inhibitor treatment blocks the escape of 1205Lu cells (PTEN) from therapy. Spheroids of 1205Lu cells were treated with either PLX4720 alone (3 and 10 μmol/L: data shows 3 mmol/L), LY294002 (10 μmol/L) alone or a combination of the 2 drugs for 72 hours. In other studies, spheroids were treated with drugs for 72 hours and then allowed to recover for 120 hours. Micrograph shows viability staining (green= live cells, red= dead cells). Magnification 10×.

    Cancer Res 2011 71, 2750-2760. Pictilisib (GDC-0941) purchased from Selleck.

  • Combination of rapamycin and PI-103 leads to the suppression of AKT phosphorylation (phospho-specific western blot). Mel-Juso and 518A2 cells were treated with GDC-0941 from 0.05–1 μmol/L alone and in combination with rapamycin (50 nmol/L) for 24 hours. Control treatment was with DMSO.

     

     

    J Inves Der 2010 131, 495-503. Pictilisib (GDC-0941) purchased from Selleck.

    Growth inhibition induced by the FGFR inhibitor BGJ398 and the PI3K inhibitors alone or in combination. AN3CA (A-C), JHUEM2 (D-F) and MFE296 (G-I) cells were treated with the indicated doses of BGJ398, GDC-0941 a n d BYL719 alone or in combination for 96 hours and an Sulforhodamine B (SRB) assay was subsequently performed. Data are presented as a percentage of the control, in which cells were treated with 0.1% (v/v) DMSO. Points represent the mean of three independent experiments (each performed in triplicate). Error bars represent the standard error of the mean (SEM) and lines were fitted using non-linear regression analysis. Interaction of BGJ398 and GDC-0941(redcircles) or BYL719(blacksquares) in AN3CA(C), JHUEM2(F) and MFE296(I). Median effect analysis was used to evaluate the interaction between the inhibitor combinations. Horizontal dotted lines indicate the boundaries for each interaction classification.

    Mol Cancer Ther, 2017.. Pictilisib (GDC-0941) purchased from Selleck.

  • TGF-β induces mTORC2 activation. ( A ) NMuMG cells were treated with TGF-β for the indicated times before lysis and immunoblotting. (B ) NMuMG cells were treated or not with TGF-β for the indicated times, in the presence or absence of SB431542 or LY294002. Cell lysates were subjected to anti-Rictor immunoprecipitation, and the immunoprecipitates were subjected to in vitro kinase assays using kinase-inactive Akt1 as a substrate, before immunoblotting of the kinase reactions, immunoprecipitates and cell lysates. The left panels are from the same gel, without differential exposure. ( C ) NMuMG cells were treated or not with TGF-β or insulin for the indicated times, in the presence or absence of SB431542 or GDC-0941. The kinase activity of mTORC2 was then assessed as in B. The top panels are from the same gel, without differential exposure. (D) NMuMG cells were treated or not with TGF-β for the indicated times, in the presence or absence of SB431542 or LY294002. Cell lysates were subjected to immunoprecipitation using Rictor antibody, and/or immunoblotted.

    J Cell Sci 2012 125(Pt 5), 1259-73. Pictilisib (GDC-0941) purchased from Selleck.

    Effects of LY294002 and GDC-0941 on the high-glucose-induced plasma membrane translocation of DGK δ1. (A, C) HEK293 cells were transfected with pAcGFP-DGKδ1 or pAcGFP-C1 vector. After being glucose-starved for 2.5 h and the subsequent pretreatment with (A) 10 μM LY294002 (Sigma-Aldrich) or (C) 1 μM GDC-0941 (Selleck Chemicals) for 30 min, the cells were incubated with or without high glucose (25 mM) for 5 min. The cells were fixed with 3.7% formaldehyde and observed using confocal laser-scanning microscopy. Scale bar = 10 μm. (B, D) After treatment with (B) LY294002 or (D) GDC-0941, the percentages of cells exhibiting the translocation of AcGFP-tagged DGK δ 1 to the plasma membrane were scored. More than 20 cells ex-pressing AcGFP-tagged DGK δ1 were counted in each experiment. The results are the means ± S.D. of three independent experiments. The statistical significance was deter-mined using Student's t -test (** P < 0.01, *** P < 0.005)

    Biochim Biophys Acta 2012 1823, 2210-6. Pictilisib (GDC-0941) purchased from Selleck.

  • After starved in serum-free medium for 24h, Breast cancer cells incubated with the indicated concentrations of GDC-0941  for 3h,followed by 15-minute  stimulation of 100ng/ml EGF.

     

     

     

    Dr. Zhang of Tianjin Medical University. Pictilisib (GDC-0941) purchased from Selleck.

    We treated all of drugs in T47D which has a PI3KCA H1044R mutation with the concentration shown below for 1 hour and performed western blot analysis using antibodies to phospho-AKT(SERINE 472), and total AKT.

     

     

    Saraswati Sukumar of Johns Hopkins University School of Medicine. Pictilisib (GDC-0941) purchased from Selleck.

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    PI3K pathway signaling in GDC-0941 and MK-2206 treated MCF-7 derivatives with PIK3CA or  AKT1 mutations. Cells were grown in medium containing 5% FBS and treated with vehicle or increasing concentrations of GDC-0941 (0 nM, 50 nM, 100 nM, and 400 nM) or MK-2206 (0 nM, 100 nM, 250 nM, 1000 nM). After 24 hours of drug treatment, lysates were prepared and equal amounts of protein were load ed onto SDS-PAGE gels and blotted with the indicated antibodies.

    Pictilisib (GDC-0941) purchased from Selleck.

Purity & Quality Control

Choose Selective PI3K Inhibitors

Biological Activity

Description Pictilisib (GDC-0941) is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM in cell-free assays, with modest selectivity against p110β (11-fold) and p110γ (25-fold). Phase 2.
Targets
p110α [1]
(Cell-free assay)
p110δ [1]
(Cell-free assay)
p110β [1]
(Cell-free assay)
p110γ [1]
(Cell-free assay)
mTOR [1]
(Cell-free assay)
3 nM 3 nM 33 nM 75 nM 0.58 μM(Ki app)
In vitro

GDC-0941 is equipotent against PI3Kα and PI3Kδ as well as PI3Kα mutants E545-K and H1047-R, displaying modest levels of selectivity against PI3Kβ (10-fold) and PI3Kγ (25-fold), and greater levels of selectivity against members of PI3K class II, III, and IV, including C2β, Vps34, DNA-PK, and mTOR. GDC-0941 potently inhibits the phosphorylation of Akt in U87MG, PC3, and MDA-MB-361 cells with IC50 of 46 nM, 37 nM, and 28 nM, respectively. GDC-0941 inhibits the proliferation of U87MG, A2780, PC3, and MDA-MB-361 cells with IC50 of 0.95 μM, 0.14 μM, 0.28 μM, and 0.72 μM, respectively. [1] GDC-0941 treatment potently inhibits the proliferation of both trastuzumab-sensitive and -insensitive HER2-amplified cells with IC50 of 149-944 nM. GDC-0941 inhibits proliferation of HER2-amplified cells that harbor PIK3CA mutations with IC50 of <500 nM, and effectively inhibits both proliferation and viability of HER2-amplified breast cancer cells that are resistant to trastuzumab due to PTEN loss. [2] GDC-0941 significantly inhibits the growth of HCT116, DLD1 and HT29 cells with GI50 of 1081 nM, 1070 nM and 157 nM, respectively. [3] GDC-0941 inhibits tumor cell proliferation, induces apoptosis and suppresses centroblast population. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Sf9 NHXRVGNMcW6jc3WgRZN{[Xl? NVfmPIVGOSCq MkjiSG1UVw>? MkfoTY5pcWKrdHnvckBw\iCqdX3hckBz\WOxbXLpcoFvfCCSSUPLJJAyOTCmZXz0ZUBmgHC{ZYPz[YQhcW5iU3[5JINmdGy|IHPv[ZhxemW|c3nu[{BxQDWjbIDoZUB4cXSqIFnDOVAhd2ZiMD6wNFMh|ryP NYTKRnJPOTh5NUS2OVQ>
Sf9 NUHIT5ozU2mwYYPlJGF{e2G7 MV6xJIg> MY\EUXNQ M2rDbmlvcGmkaYTpc44hd2ZiaIXtZY4hemWlb33ibY5idnRiUFmzT{BxOTFyYnX0ZUBJOTB2Nz3SJI12fGGwdDDlfJBz\XO|ZXSgbY4hW2Z7IHPlcIx{KGOxZYjwdoV{e2mwZzDwPFVidHCqYTD3bZRpKEmFNUCgc4YhOC5yMEOg{txO MVqxPFc2PDZ3NB?=
Sf9 MXvLbY5ie2ViQYPzZZk> NGjo[IYyKGh? M2XPXmROW09? MlT0TY5pcWKrdHnvckBw\iCqdX3hckBz\WOxbXLpcoFvfCCSSUPLJJAyOTCkZYThJGU2PDVvSzDteZRidnRiZYjwdoV{e2WmIHnuJHNnQSClZXzsd{Bkd2W6cILld5NqdmdicEi1ZYxxcGFid3n0bEBKSzVyIH;mJFAvODB|IN88US=> MUSxPFc2PDZ3NB?=
Sf9 MlzhT4lv[XOnIFHzd4F6 MWGxJIg> MWfEUXNQ NWG0fXhbUW6qaXLpeIlwdiCxZjDoeY1idiC{ZXPvcYJqdmGwdDDQTVNMKHBzMUDi[ZRiKGW6cILld5Nm\CCrbjDT[lkh[2WubIOgZ49mgHC{ZYPzbY5oKHB6NXHsdIhiKHerdHigTWM2OCCxZjCwMlA{OyEQvF2= MVSxPFc2PDZ3NB?=
Sf9 MkD0T4lv[XOnIFHzd4F6 MofDNUBp NYXafWg1TE2VTx?= NXnyV5Z1UW6qaXLpeIlwdiCxZjDoeY1idiC{ZXPvcYJqdmGwdDDQTVNMKHBzMUDhcJBp[SCneIDy[ZN{\WRiaX6gV4Y6KGOnbHzzJINw\XiycnXzd4lv\yCyOEXhcJBp[Q>? M4fKXFE5PzV2NkW0
MDA-MB-361 NIL2SGVHfW6ldHnvckBCe3OjeR?= NF7LOJgzKGh? NVO4Z3dwTE2VTx?= NFrlNm5KdmirYnn0bY9vKG:oIFHreEBU\XJ2N{OgdIhwe3Cqb4L5cIF1cW:wIHnuJIh2dWGwIF3ERU1OSi1|NkGgZ4VtdHNid3n0bEBRUUt|Q1GgSVU1PS2NIH31eIF1cW:wIIfpeIghUUN3MDDv[kAxNjB{ODFOwG0> NVfjRWlROTh5NUS2OVQ>
PC3 MmPRSpVv[3Srb36gRZN{[Xl? M3K3SlIhcA>? MYfEUXNQ MlzuTY5pcWKrdHnvckBw\iCDa4SgV4VzPDd|IIDoc5NxcG:{eXzheIlwdiCrbjDQWGVPNW63bHygbJVu[W5iUFOzJINmdGy|IIfpeIghUUN3MDDv[kAxNjB|NzFOwG0> MV2xPFc2PDZ3NB?=
U87MG NWfNO5hwTnWwY4Tpc44hSXO|YYm= NF;IWYIzKGh? NFHxc29FVVOR MX7Jcohq[mm2aX;uJI9nKEGtdDDT[ZI1PzNicHjvd5Bpd3K7bHH0bY9vKGmwIGDUSW4udnWubDDoeY1idiCXOEfNS{Bk\WyuczD3bZRpKEmFNUCgc4YhOC5yNE[g{txO NUWx[I5nOTh5NUS2OVQ>
MDA-MB-361 M4fYemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVjaSJlSQTZiaB?= NVHj[ndDTE2VTx?= NFfPRYtCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3ERU1OSi1|NkGgZ4VtdHNid3n0bEBRUUt|Q1GgSVU1PS2NIH31eIF1cW:wIIfpeIghUUN3MDDv[kAxNjd{IN88US=> NGHVWYMyQDd3NE[1OC=>
A2780 NVPjT2F7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4DzNlk3KGh? MlzxSG1UVw>? M{[5SWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQUK3PFAh[2WubIOge4l1cCCSSVuzR2Eh[W6mIGDUSW4hdXW2YYTpc44hf2m2aDDJR|UxKG:oIECuNVQh|ryP MVyxPFc2PDZ3NB?=
PC3 Mn3pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVq5OkBp MliwSG1UVw>? NEC2fHBKSzVyPUCuNlgh|ryP MYexPFc2PDZ3NB?=
U87MG NFT2d41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGrER5U6PiCq Ml33SG1UVw>? MmnmTWM2OD1yLkm1JO69VQ>? NF7rR20yQDd3NE[1OC=>
Sf9 MV7LbY5ie2ViQYPzZZk> NV\vfG0xOzBibXnu NYDkdFVzTE2VTx?= MWTJcohq[mm2aX;uJI9nKGi3bXHuJHBKO0upYX3tZUBmgHC{ZYPz[YQh[XO|ZYPz[YQh[XNiYX3veY51KG:oIFHUVEBkd26|dX3l[EB4cXSqIFnDOVAhd2ZiMD6wOFIh|ryP M2TxcVIzPTR6M{Sy
RAW 264.7 M{Wwc2tqdmG|ZTDBd5NigQ>? MlLqPVAhdWmw M{nHNmROW09? MljPTY5pcWKrdHnvckBw\iCqdX3hckBRUTONZ3HtcYEh\XiycnXzd4VlKGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4YhSUuWIIDoc5NxcG:{eXzheIlwdiC5aYToJGlEPTBib3[gNE4zQThizszN M2SySVIzPTR6M{Sy
Sf9 NWPwe|Z1U2mwYYPlJGF{e2G7 Mmf0NUBp MmH6TY5pcWKrdHnvckBw\iCJU2St[pV{\WRiaIXtZY4hemWlb33ibY5idnRiUFmzT4JmfGFiZYjwdoV{e2WmIHnuJIJi[3Wub4\pdpV{KGmwZnXjeIVlKFOIOTDj[YxteyC5aYToJGlEPTBib3[gNE4xOTdizszN NXvKTWRROjN3NEC2OFU>
Sf9 NVXmXnRjU2mwYYPlJGF{e2G7 MYKxJIg> NWHIV5FmUW6qaXLpeIlwdiCxZjDHV3Qu\nW|ZXSgbJVu[W5icnXjc41jcW6jboSgVGk{U2SnbIThJIV5eHKnc4Pl[C=> MVqyN|U1ODZ2NR?=
Sf9 M1X3SWtqdmG|ZTDBd5NigQ>? M4L6OFEhcA>? M2TWNmlvcGmkaYTpc44hd2ZiR2PUMYZ2e2WmIHj1cYFvKHKnY3;tZolv[W62IGDJN2to[W2vYTDlfJBz\XO|ZXS= M2HHXFI{PTRyNkS1
Sf9 NXToTnRPU2mwYYPlJGF{e2G7 M{XW[VEhcA>? NUDVU5U5UW6qaXLpeIlwdiCxZjDHV3Qu\nW|ZXSgbJVu[W5icnXjc41jcW6jboSgVGk{U2GucHjhJIV5eHKnc4Pl[C=> NWH0[YRTOjN3NEC2OFU>
SKOV3 MWfLbY5ie2ViQYPzZZk> NXT1[npDOSEQvF2= NGGyeoYyKGh? NYPHTYFmTE2VTx?= NWrOOXA5UW6qaXLpeIlwdiCxZjDQTVNM[WyyaHGgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDBb5QhW2W{NEezJJBpd3OyaH;yfYxifGmxbh?= NILaXoEzOzN4MEO0PC=>
MCF7 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUKxJO69VQ>? M3fqbVk3KGh? M2f2O2ROW09? MWPHTVUxRTBwMEewNkDPxE1? NYXSdoI{OjN|NkCzOFg>
SKOV3 M2rlVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4T2Z|Eh|ryP NVva[GpSQTZiaB?= M2DaNmROW09? MnzaS2k2OD1yLkG0O|Yh|ryP MnLFNlM{PjB|NEi=
PC3 NEKxcoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY[3NkBp Mm\rSG1UVw>? MXjJR|UxRTBwMkig{txO MVKyNVk5OTdzNB?=
MCF7.1 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1jafVczKGh? MWnEUXNQ MlrtRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPQ1[3MlEh[2WubIOg[ZhxemW|c3nu[{BJTVJ{IHflcoUhf2m2aDDJR|UxKG:oIECuNlgh|ryP M1nhSlIyQThzN{G0
MCF7-neo/Her2 MnixS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3TPUFczKGh? NELxNnlFVVOR NHvaVVhKSzVyPUCuNlkh|ryP M{C2N|I{PjZ{OUCz
MCF7-neo/Her2 M2DX[2tqdmG|ZTDBd5NigQ>? Mny3TY5pcWKrdHnvckBw\iCSSUPLZYxxcGFiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJI9nKEGNVDDwbI9{eGixconsZZRqd25iYYSgV|Q4OyC5aYToJGlEPTBib3[gNE4xODdizszN MY[yN|Y3OjlyMx?=
PC3 M{HjTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVjTdm93PzJiaB?= Mn7GSG1UVw>? MmPoSWM2OD1yLkO0JO69VQ>? NFHTVHAzOTl6NU[zPS=>
MCF7.1 NFTIVZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmD6O|IhcA>? M4q2OmROW09? MVjBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2FRkeuNUBk\WyuczDlfJBz\XO|aX7nJHBKO0ujbIDoZUBufXSjboSge4l1cCCHQ{WwJI9nKDBwM{mg{txO M3;iVFIyQTh3NkO5
PC3 NE\ke|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYfZS5RSPzJiaB?= NFzi[IxFVVOR MV3BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFCFMzDj[YxteyCmZX\pZ4lmdnRiaX6gVHRGViC5aYToJGlEPTBib3[gNE4{QSEQvF2= M4DXeVIxODVyNk[5
MCF7.1 NVn6R2JOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFLSXow4OiCq MWjEUXNQ MX3BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2FRkeuNUBk\WyuczDlfJBz\XO|aX7nJHBKO0ujbIDoZUBufXSjboSge4l1cCCLQ{WwJI9nKDBwM{Sg{txO NHq0bXUzODB3ME[2PS=>
MCF7.1 NV7JZVZLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV;lVGFtPzJiaB?= MnzXSWM2OD1yLkeyJO69VQ>? NFHXdpYzODN2Nk[1Oi=>
NCI-H1975 M2jzOGN6fG:2b4jpZ{BCe3OjeR?= MV23NkBp NIWyS3NKSzVyPUCuNlch|ryP M1;qRVI{ODV7NUS1
H460 MVHDfZRwfG:6aXOgRZN{[Xl? NX7teI1QPzJiaB?= NIfqSJlKSzVyPUCuPFch|ryP NXKzUZl5OjNyNUm1OFU>
HT-29 MkjKR5l1d3SxeHnjJGF{e2G7 NV7iTHBsPzJiaB?= NIO2VXRKSzVyPUCuOlYh|ryP M1qydVI{ODV7NUS1
HepG2 Ml;tR5l1d3SxeHnjJGF{e2G7 MmjLO|IhcA>? NV\kenFNUUN3ME2xJO69VQ>? MWSyN|A2QTV2NR?=
SGC7901 NXG2TYxHS3m2b4TvfIlkKEG|c3H5 NITmOHg4OiCq MWnJR|UxRTFwODFOwG0> M{nGTlI{ODV7NUS1
NCI-H226 NXmzeJpjS3m2b4TvfIlkKEG|c3H5 NGn0fIw4OiCq M{f0VGlEPTB;Mj65JO69VQ>? MojLNlMxPTl3NEW=
A549 M13PU2N6fG:2b4jpZ{BCe3OjeR?= NHTRcWE4OiCq M3zGXGlEPTB;Nj65JO69VQ>? NEjPWVYzOzB3OUW0OS=>
U87MG MUPDfZRwfG:6aXOgRZN{[Xl? M{jsWFczKGh? M2XFSWlEPTB;Nz63O{DPxE1? MVmyN|A2QTV2NR?=
HBC4 NIe2eJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV7we45odG:pR1m1NF0uPi5yMzDN MUmyNlM{PjJ2Nh?=
BSY1 M4rCVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjsc4dIUTVyPT22MlkxKE1? NVzIWGo2OjJ|M{[yOFY>
HBC5 M1q3bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlPncI9oT0l3ME2tOk43OCCP NYjjfIJjOjJ|M{[yOFY>
MCF7 NHr3TGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV\sc4dIUTVyPT23MlM{KE1? NX7zUHBQOjJ|M{[yOFY>
MDA-MB-231 M2Lp[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYTHR2MydG:pR1m1NF0uPS52NjDN M2rlW|IzOzN4MkS2
U251 NUnnN5g{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnGzcI9oT0l3ME2tOU42OCCP MkS3NlI{OzZ{NE[=
SF268 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV3zR2NHdG:pR1m1NF0uPS5|OTDN NUnQcWd7OjJ|M{[yOFY>
SF295 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmTYcI9oT0l3ME2tOk4{PyCP MViyNlM{PjJ2Nh?=
SF539 MofCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfsc4dIUTVyPT22MlUxKE1? MWCyNlM{PjJ2Nh?=
SNB75 NETub5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUXCenJLdG:pR1m1NF0uPy5zMDDN M2LDO|IzOzN4MkS2
SNB78 NXfKdJNMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\Me4xw\0eLNUC9MVYvPTJiTR?= M4TyV|IzOzN4MkS2
HCC2998 M1HJSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYHIPVU6dG:pR1m1NF0uPi5{OTDN MnfENlI{OzZ{NE[=
KM12 MmnKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXLzcIs{dG:pR1m1NF0uPS55NjDN NFzJ[HgzOjN|NkK0Oi=>
HT-29 NV\KSGRtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlf3cI9oT0l3ME2tOk4{OCCP MXyyNlM{PjJ2Nh?=
HCT15 NYLNW4RtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NESwemxtd2eJSUWwQU03NjF{IF2= NH\kVnQzOjN|NkK0Oi=>
HCT116 M1jiVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2T6eIxw\0eLNUC9MVUvQDdiTR?= NVjz[Jp{OjJ|M{[yOFY>
NCI-H23 M4nISmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmTZcI9oT0l3ME2tOU44OyCP M1vCXFIzOzN4MkS2
NCI-H226 NEnFPVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXT2ZYJJdG:pR1m1NF0uPi5{MTDN NELtNmMzOjN|NkK0Oi=>
NCI-H522 MkT6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLsc4dIUTVyPT22MlU5KE1? NY\oSnVOOjJ|M{[yOFY>
NCI-H483 NXjnfJBsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoTicI9oT0l3ME2tOk42PiCP MlrvNlI{OzZ{NE[=
A549 NVjrelJ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnsc4dIUTVyPT22MlE2KE1? NWDpb4l[OjJ|M{[yOFY>
DMS273 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVvwNpI2dG:pR1m1NF0uPi52MzDN NHXKfGQzOjN|NkK0Oi=>
DMS114 MnnIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGm1[HNtd2eJSUWwQU02Njl{IF2= NGPvd2IzOjN|NkK0Oi=>
LOXIMVI MkPjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYLGVWp1dG:pR1m1NF0uPi5{OTDN NFjhT4EzOjN|NkK0Oi=>
OVCAR3 NYL4RpVWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYrsc4dIUTVyPT22MlcyKE1? NILl[pgzOjN|NkK0Oi=>
OVCAR4 M2HpOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVW2NIxEdG:pR1m1NF0uPS55NjDN NFyy[WIzOjN|NkK0Oi=>
OVCAR5 NGXSUZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUf5bHc1dG:pR1m1NF0uPi5{NjDN M1jEdFIzOzN4MkS2
OVCAR8 NYPaW5FVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3HxbIxw\0eLNUC9MVUvPzNiTR?= MWOyNlM{PjJ2Nh?=
SKOV3 M4fnfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHWcI9oT0l3ME2tOk42OiCP NX3aVY9lOjJ|M{[yOFY>
RXF631L NWLnSVJ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYPERoc4dG:pR1m1NF0uPi56ODDN MlX0NlI{OzZ{NE[=
ACHN NH\YZlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;ZcI9oT0l3ME2tOk4xPyCP MVGyNlM{PjJ2Nh?=
St-4 MoX6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4K5VIxw\0eLNUC9MVUvPTZiTR?= NEHCNXAzOjN|NkK0Oi=>
MKN1 NF3HcoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUDkeWZndG:pR1m1NF0uPy5yODDN MYmyNlM{PjJ2Nh?=
MKN7 NIfFUJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4TKdYxw\0eLNUC9MVYvPTBiTR?= NGXHNI8zOjN|NkK0Oi=>
MKN28 M3\BWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1XOSIxw\0eLNUC9MVUvPTJiTR?= M1SxSVIzOzN4MkS2
MKN45 NHPuWWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml7EcI9oT0l3ME2tOk42PSCP M2S0dVIzOzN4MkS2
MKN74 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYfsc4dIUTVyPT22MlAzKE1? M33UWFIzOzN4MkS2
DU145 NISxWm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVzGWoJndG:pR1m1NF0uPS56NTDN M{K0TFIzOzN4MkS2
PC3 M1L4[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M37OZ4xw\0eLNUC9MVYvPjZiTR?= NGPGN2YzOjN|NkK0Oi=>
ES5 M3KzUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\HXmlEPTB;NUCuNlEhdk1? M1HHR3NCVkeHUh?=
HH MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTFzMT6wPEBvVQ>? NEDLOINUSU6JRWK=
MHH-PREB-1 M3zCOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVvu[YcyUUN3ME2xNVQvOyCwTR?= NV3teFc2W0GQR1XS
NCI-H1770 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEXU[IpKSzVyPUGyN{45PiCwTR?= MV7TRW5ITVJ?
HuO9 M1HZcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTJyNj6wNkBvVQ>? MlrBV2FPT0WU
HAL-01 NYLjT5Y{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIrNeGZKSzVyPUKwOk44OyCwTR?= NGXhO2NUSU6JRWK=
NOS-1 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3jldWlEPTB;MkGxMlgzKG6P NXzhW|dnW0GQR1XS
HGC-27 MkjGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlPKTWM2OD1{MUKuOVchdk1? M1PoSXNCVkeHUh?=
NB69 NGG0W3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUPDSnRJUUN3ME2yOFUvOjdibl2= NWjScVN3W0GQR1XS
RS4-11 NFzNSo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTJ4MT63OkBvVQ>? MX\TRW5ITVJ?
DOK MlzWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NITZPGJKSzVyPUOwNU44KG6P NXjSTYx6W0GQR1XS
LB2241-RCC MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTNyMz64OEBvVQ>? NYf5eJgzW0GQR1XS
NCI-H1623 MlSzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGLydopKSzVyPUOwOE4xQCCwTR?= M1vwU3NCVkeHUh?=
YH-13 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NITUSVBKSzVyPUOwOE4{OiCwTR?= M1PveXNCVkeHUh?=
BPH-1 M1vDOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWD1b29UUUN3ME2zNVQhdk1? MlT6V2FPT0WU
AN3-CA Ml7nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTN2MD6zO{BvVQ>? NFXxPHBUSU6JRWK=
ES7 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlfxTWM2OD1|NEGuPVkhdk1? NVflZoVOW0GQR1XS
MDA-MB-175-VII NX73Z2QzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4HEO2lEPTB;M{WyMlkzKG6P M3\4OXNCVkeHUh?=
GAMG MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH7HbFVKSzVyPUO3NE45PSCwTR?= NFTPcoRUSU6JRWK=
CHL-1 NX\BR|VXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2DEWWlEPTB;M{e4MlY2KG6P M1LSS3NCVkeHUh?=
NB7 NUfKWWd7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{L2OGlEPTB;M{i5Mlg{KG6P Mme5V2FPT0WU
MFE-280 NH;LPXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlPBTWM2OD12MUiuNkBvVQ>? NFXkeW5USU6JRWK=
HL-60 M3TyXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2TPbGlEPTB;NEK1Mlc2KG6P NFvRb2NUSU6JRWK=
GCIY MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MonwTWM2OD12M{OuPEBvVQ>? M4n0WHNCVkeHUh?=
MDA-MB-361 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVPJR|UxRTR|OT6xN{BvVQ>? MXjTRW5ITVJ?
LXF-289 NX7vO49LT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4PtTGlEPTB;NES4MlI4KG6P NYPKNJJtW0GQR1XS
NBsusSR M1nwWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTR6OD64OUBvVQ>? MVvTRW5ITVJ?
KU-19-19 NIHKW4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWTGVVdTUUN3ME21NVYvODdibl2= M1zGRnNCVkeHUh?=
A204 NH7BS4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIrJW|NKSzVyPUWyNk4{OyCwTR?= M3v6fnNCVkeHUh?=
LB1047-RCC MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXHqO282UUN3ME21NlIvQTNibl2= MlnaV2FPT0WU
COLO-684 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTV{Mz6xNUBvVQ>? MXfTRW5ITVJ?
PA-1 MkjNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUfZZXRpUUN3ME21N|IvPDFibl2= M1O5PHNCVkeHUh?=
MG-63 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlnFTWM2OD13NEGuNVEhdk1? NXm1bXp4W0GQR1XS
BHT-101 NEjlcGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7Wd5RKSzVyPUW0OE46PCCwTR?= M4jzVHNCVkeHUh?=
NKM-1 NHK5WY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M33LR2lEPTB;NUmzMlA6KG6P NUHpdmt3W0GQR1XS
T47D NGPU[FlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\iSVdGUUN3ME21PVcvPTZibl2= NF\GRphUSU6JRWK=
MOLT-4 NWfGeGl2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTZ{Mz62NkBvVQ>? NXPPfGJNW0GQR1XS
IGROV-1 MlLRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFLo[pBKSzVyPU[zOE4{OSCwTR?= Mle0V2FPT0WU
ES4 Ml3oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGL2XoZKSzVyPU[zPU42PCCwTR?= NXjCTFFlW0GQR1XS
HuO-3N1 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{niSGlEPTB;NkSyMlM5KG6P NF\oUJlUSU6JRWK=
NEC8 NIXDenNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTZ3Mz61O{BvVQ>? MnjxV2FPT0WU
HO-1-N-1 M321PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M37XRmlEPTB;NkW5MlE4KG6P M{HrbXNCVkeHUh?=
EPCL-272H MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTZ6Nz6yNUBvVQ>? M3rMXXNCVkeHUh?=
D-263MG NUm0[m5qT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVGyXGtPUUN3ME23NVgvOSCwTR?= NWPM[WlFW0GQR1XS
MV-4-11 NHvac49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXrpfY5yUUN3ME23NlQvOzFibl2= NVzmbmlCW0GQR1XS
SK-NEP-1 MnLBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTd{NT65OEBvVQ>? MljRV2FPT0WU
SW872 NUDzUYw2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHjXPYtKSzVyPUeyO{45QSCwTR?= NV33T|VDW0GQR1XS
P30-OHK MlHBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn;3TWM2OD15M{CuO|Ehdk1? NXzUXJg1W0GQR1XS
OMC-1 NIDuUpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1jIN2lEPTB;N{WxMlA6KG6P M1u2fnNCVkeHUh?=
LoVo MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGfWdmJKSzVyPUe3O{46KG6P NFXxTndUSU6JRWK=
LNCaP-Clone-FGC M4[yeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVz4S|JkUUN3ME23PVYvOzRibl2= NV3ETHdNW0GQR1XS
L-363 MnvpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXnVN2xvUUN3ME23PVgvPDJibl2= MlrHV2FPT0WU
ES8 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlT0TWM2OD16MUCuOVIhdk1? NV[1fHhKW0GQR1XS
697 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV24PVd[UUN3ME24N|EvPTVibl2= MVrTRW5ITVJ?
HSC-3 NF:2TYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2[0[2lEPTB;OEO5MlU1KG6P MWHTRW5ITVJ?
H4 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIXiRXZKSzVyPUi1NE45PSCwTR?= MofvV2FPT0WU
QIMR-WIL MkLzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV7JR|UxRTh4NT6yJI5O MWnTRW5ITVJ?
OAW-42 M3W2[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTh5Mj6xPUBvVQ>? MVnTRW5ITVJ?
MCF7 NV;uOop1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVnTVZNqUUN3ME24PVgvPTlibl2= NITqZ5JUSU6JRWK=
SCC-25 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnf2TWM2OD17MUSuNVkhdk1? Mnj4V2FPT0WU
NCI-H1563 M3\scmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnGwTWM2OD17MUWuPVkhdk1? MYnTRW5ITVJ?
OVCAR-5 NUHRV5Q5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTl2MD6xO{BvVQ>? NY\5fmJoW0GQR1XS
HDLM-2 NFfke|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFLFT4hKSzVyPUm0PU4zKG6P NFz4WIxUSU6JRWK=
NB5 M3jZVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{LscWlEPTB;OUW2MlYhdk1? MYnTRW5ITVJ?
NCI-H292 M3TaV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoDmTWM2OD17N{SuN|Ihdk1? MkLrV2FPT0WU
A101D Ml7mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXH4dYhoUUN3ME25PVAvOTlibl2= NG[4SodUSU6JRWK=
NCI-H1648 NIDKVZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn7QTWM2OD17OUiuOVEhdk1? NWnLUFQ5W0GQR1XS
EKVX MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlHLTWM2OD1zLkCxNlkh|ryP NWq3PVBrW0GQR1XS
SW1710 NXyyW3VWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn34TWM2OD1zLkC0NlM{KM7:TR?= NX;jS4dMW0GQR1XS
WM-115 NH\uS4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\rRWlEPTB;MT6wOlY2PiEQvF2= M2jWSHNCVkeHUh?=
CAL-54 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTFwMEewPFEh|ryP NHLIN3pUSU6JRWK=
TGBC24TKB MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEnsXpVKSzVyPUGuNFgxPDVizszN MXvTRW5ITVJ?
NCI-H520 MlrqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{TITWlEPTB;MT6wPFk3PyEQvF2= NVLsVo1DW0GQR1XS
D-423MG MlzMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3[xW2lEPTB;MT6wPVk3OiEQvF2= NEH1TppUSU6JRWK=
BFTC-905 M4noVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3HQW2lEPTB;MT6xN|Q1QSEQvF2= NF\OZZpUSU6JRWK=
HT MnXyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnXnTWM2OD1zLkGzOFc5KM7:TR?= NUfj[IE5W0GQR1XS
CTB-1 NY\0PFRuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFP5[3pKSzVyPUGuNVQzQTNizszN M4qxSnNCVkeHUh?=
Hs-578-T NYO3R21bT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTFwMUm1OlUh|ryP MWHTRW5ITVJ?
HuH-7 MlSyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnXQTWM2OD1zLkKwPVQ6KM7:TR?= NF3lcoJUSU6JRWK=
LB996-RCC MkfYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmnnTWM2OD1zLkKyNVc4KM7:TR?= MnGxV2FPT0WU
KYSE-270 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTFwMkm3N|Qh|ryP MWrTRW5ITVJ?
A4-Fuk MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3XwNGlEPTB;MT6yPVk6OyEQvF2= M320cnNCVkeHUh?=
A498 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEnMTI9KSzVyPUGuN|A1PzRizszN NXLHPY5xW0GQR1XS
SK-MEL-1 NIPZb5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2XPWmlEPTB;MT6zNFY4QSEQvF2= NFTae5RUSU6JRWK=
AU565 MnHOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NETFdoRKSzVyPUGuN|E5PjNizszN NIq4ZnNUSU6JRWK=
Saos-2 NX7W[oRVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXfJR|UxRTFwM{OyNFUh|ryP NGe2eWdUSU6JRWK=
A549 NGrDWIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUjITHdvUUN3ME2xMlM6QTdizszN M{LYVXNCVkeHUh?=
BFTC-909 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTFwNEOzNFUh|ryP NWWy[21QW0GQR1XS
MDA-MB-415 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWiyb|lmUUN3ME2xMlQ5Pjl{IN88US=> NFrsV4dUSU6JRWK=
639-V MnLvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mon3TWM2OD1zLkWwNlQ2KM7:TR?= M3zWR3NCVkeHUh?=
A704 NGH4TFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUf5emlQUUN3ME2xMlUxPzh3IN88US=> MoTpV2FPT0WU
PANC-03-27 M2fmUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml\lTWM2OD1zLkWxOFA5KM7:TR?= Mor1V2FPT0WU
SK-MEL-28 MknYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTFwNU[wPFUh|ryP M1PrOnNCVkeHUh?=
Ramos-2G6-4C10 NXe3WW5QT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGrXTGZKSzVyPUGuOlA4PDZizszN M1H1NXNCVkeHUh?=
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KYSE-450 M{DjNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTJ5Lkm4OlIh|ryP NFrmWYJUSU6JRWK=
S-117 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{PyfGlEPTB;MkmuN|g2PyEQvF2= NXPHVGRrW0GQR1XS
SW13 NGK1fWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkG4TWM2OD1{OT64OVE6KM7:TR?= MVnTRW5ITVJ?
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NCI-H2170 NEjO[3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVLwR5ViUUN3ME2zNU42Pzh2IN88US=> M{LRenNCVkeHUh?=
ALL-PO NXXIXnNGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4jldWlEPTB;M{GuPFQzQCEQvF2= NGqxUHBUSU6JRWK=
NCI-H661 Mn\hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXTSfphVUUN3ME2zNk4xPjJ|IN88US=> Mn;iV2FPT0WU
NCI-H2347 NXPhOmFwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkjFTWM2OD1|Mj60PFM4KM7:TR?= MVnTRW5ITVJ?
FTC-133 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGPDblFKSzVyPUOyMlcxPiEQvF2= MUDTRW5ITVJ?
COLO-829 NWqx[402T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlvsTWM2OD1|Mz6zOFY4KM7:TR?= NVjFXIx6W0GQR1XS
GOTO M2\ncmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVfQN5RNUUN3ME2zN{42OjV6IN88US=> M{nPXnNCVkeHUh?=
YAPC MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTN|LkixOVkh|ryP MUjTRW5ITVJ?
LCLC-103H NEfoTXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTN2LkG2NlQh|ryP Mmj4V2FPT0WU
SiHa NF;RPXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\zfWlEPTB;M{SuN|gyPyEQvF2= M2HzOHNCVkeHUh?=
LK-2 M33XTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX7JR|UxRTN2LkW3NFgh|ryP MnfCV2FPT0WU
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NCI-SNU-1 NVH6TYcxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGnXTGFKSzVyPUO1MlE4QSEQvF2= MYXTRW5ITVJ?
KNS-81-FD MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTN3Lk[2N{DPxE1? MXfTRW5ITVJ?
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SH-4 NEDrWGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFvvSGVKSzVyPUO2Mlc{KM7:TR?= M4fp[3NCVkeHUh?=
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COLO-678 M{jpZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnKyTWM2OD1|Nz65OFM4KM7:TR?= NXfHSlF6W0GQR1XS
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OAW-28 NXvCVnJ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4PyV2lEPTB;M{iuOlM6KM7:TR?= MoTRV2FPT0WU
CAMA-1 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTN6Lkm2PVEh|ryP NV31[mY2W0GQR1XS
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A3-KAW M2TXO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTRyLkO2OlEh|ryP M3jGTXNCVkeHUh?=
SK-MEL-24 NVK4c2ZXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVLJR|UxRTRyLkW5N|Eh|ryP MY\TRW5ITVJ?
KYSE-140 M4DrWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTRyLkexOlUh|ryP Ml65V2FPT0WU
MOLT-16 M{Tncmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4C5SWlEPTB;NEGuNVU{PiEQvF2= MnvaV2FPT0WU
CFPAC-1 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVLJO20zUUN3ME20Nk42OjFzIN88US=> MnTvV2FPT0WU
NB14 NW\nZotuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmTOTWM2OD12Mj63NFI4KM7:TR?= M4jURXNCVkeHUh?=
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RH-1 NEHSfYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVe3VWE1UUN3ME20N{41QDN4IN88US=> MY\TRW5ITVJ?
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KGN NGPRU4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVvjWGlDUUN3ME20PE4{ODZ|IN88US=> MX;TRW5ITVJ?
UACC-62 M3TBdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIqx[WdKSzVyPUS4MlQxPzJizszN NF3aV29USU6JRWK=
NCI-H358 NF31OmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{XESGlEPTB;NEmuN|AyQCEQvF2= M1O0enNCVkeHUh?=
LS-411N M13IeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFSzXYNKSzVyPUS5MlMyOThizszN NYPNOWluW0GQR1XS
IST-MES1 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF;3VmtKSzVyPUS5MlU3OjVizszN MojvV2FPT0WU

... Click to View More Cell Line Experimental Data

In vivo GDC-0941 shows limited microsomal metabolism, resulting in 78% oral bioavailability [5]. Administration of GDC-0941 at 75 mg/kg/day displays significant inhibitory effect against established human U87MG glioblastoma xenografts in female NCr athymic mice, with tumor growth inhibition of 83%. [1] Oral administration of GDC-0941 at 150 mg/kg/day inhibits the growth of HER2-amplified, trastuzumab-resistant MDA-MB-361.1 xenografts in mice, and significantly delays the tumor progression, in association with potent induced apoptosis in tumors. [2] GDC-0941 (75 mg/kg/day) treatment for 2 weeks induces ~40% reduction in tumor volume of spontaneous B-cell follicular lymphomas developed in PTEN+/-LKB1+/hypo mice, accompanied by ablation of phosphorylation of Akt, S6K and SGK (serum and glucocorticoid protein kinase) protein kinases. [4]

Protocol

Kinase Assay:

[1]

+ Expand

Scintillation proximity assay:

Recombinant human PI3Kα, PI3Kβ, and PI3Kδ are coexpressed in a Sf9 baculovirus system with the p85α regulatory subunit and purified as GST-fusion proteins using affinity chromatography on glutathione-sepharose. Recombinant human PI3Kγ is expressed as monomeric GST-fusions and purified similarly. GDC-0941 is dissolved in DMSO and added to 20 mM Tris-HCl (pH 7.5) containing 200 μg yttrium silicate (Ysi) polylysine SPA beads, 4 mM MgCl2, 1 mM dithiothreitol (DTT), 1 μM ATP, 0.125 μCi [γ-33P]-ATP, and 4% (v/v) DMSO in a total volume of 50 μL. The recombinant GST-fusion of PI3Kα (5 ng), PI3Kβ (5 ng), PI3Kδ (5 ng), or PI3Kγ (5 ng) is added to the assay mixture to initiate the kinase reaction. After incubation for 1 hour at room temperature, the kinase reaction is terminated with 150 μL PBS. The mixture is then centrifuged for 2 minutes at 2000 rpm and read using a Wallac Microbeta counter. The reported IC50 values are calculated using a sigmoidal, dose-response curve fit in MDL Assay Explorer.
Cell Research:

[2]

+ Expand
  • Cell lines: SKBR-3, BT474-M1, AU-565, HCC-1419, ZR75-30, KPL-4, JIMT-1, BT474-EEI, HCC-1954, MCF-7, CALU-3, SKOV-3, and MKN-7 cells
  • Concentrations: Dissolved in DMSO, final concentrations ~10 μM
  • Incubation Time: 48 and 72 hours
  • Method:

    Cells are exposed to various concentrations of GDC-0941 for 48, and 72 hours. Proliferation/viability of cells is detected by using the CellTiter-Glo Luminescent Cell Viability Assay. The pAkt (Ser473), cleaved caspase-3, and cleaved PARP are analyzed by western blot. The Caspase-Glo 3/7 assay and the Cell Death Detection ELISAplus assay are used to detect caspase 3/7 activity, and apoptosis, respectively.


    (Only for Reference)
Animal Research:

[2]

+ Expand
  • Animal Models: NCR nude mice implanted with MDA-MB-361.1 cells, and SCID, C.B-17/IcrHsd-Prkdcscid mice implanted subcutaneously with BT474-M1 cells
  • Formulation: Dissolved in 10% DMSO, 5% Tween 20, 85% water
  • Dosages: ~150 mg/kg/day
  • Administration: Oral gavage
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 44 mg/mL (85.66 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order:
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
For best results, use promptly after mixing.
5mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 513.64
Formula

C23H27N7O3S2

CAS No. 957054-30-7
Storage powder
Synonyms RG7321

Bio Calculators

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00999128 Completed Healthy Volunteers Genentech, Inc. October 26, 2009 Phase 1
NCT02092831 Completed Healthy Volunteer Genentech, Inc. April 2014 Phase 1
NCT01740336 Active, not recruiting Breast Cancer Genentech, Inc. February 2013 Phase 2
NCT01493843 Completed Non-Squamous Non-Small Cell Lung Cancer Genentech, Inc. January 2012 Phase 2
NCT01474668 Completed Healthy Volunteer Genentech, Inc. October 2011 Phase 1
NCT01437566 Completed Breast Cancer Genentech, Inc. October 2011 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID