Pictilisib (GDC-0941)

Catalog No.S1065 Synonyms: RG7321

Pictilisib (GDC-0941) Chemical Structure

Molecular Weight(MW): 513.64

Pictilisib (GDC-0941) is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM in cell-free assays, with modest selectivity against p110β (11-fold) and p110γ (25-fold). Phase 2.

Size Price Stock Quantity  
In DMSO USD 240 In stock
USD 120 In stock
USD 170 In stock
USD 370 In stock
USD 970 In stock

Free Overnight Delivery on orders over $ 500
Next day delivery by 10:00 a.m. Order now.

Cited by 58 Publications

8 Customer Reviews

  • Dual PI3K/BRAF inhibition upregulates BIM and enhances apoptosis in PTEN cells. A, left, Western blot of 1205Lu cells treated with PLX4720 (3 μmol/L, 48 hours), the PI3K inhibitor GDC-0941 (3 μmol/L, 48 hours), or both drugs in combination (PtG); right, immunofluorescence staining of BIM (green) and DAPI (blue) in PTEN cells following PLX4720 treatment (3 μmol/L, 48 hours), the PI3K inhibitor LY294002 (10 μmol/L, 48 hours), or both drugs in combination (PLXtLY). B, left, immunofluorescence staining of PTEN 1205Lu following combined inhibition (3 μmol/L PLX4720 t 10 μmol/L LY294002, 48hours) increases nuclear localization of FOXO3a (green). DAPI is shown in blue. Magnification 40. Right, combined inhibition (3 μmol/L PLX4720 t 10 μmol/L LY294002, 48 hours) increases PTEN WM793 BIM mRNA levels to those observed with single BRAF inhibition (3 μmol/L PLX4720, 48 hours) in the PTENt WM35. C, PTEN cells were treated with PLX4720 (3 μmol/L, 48 hours), GDC-0941 (3 μmol/L, 48hours), or a combination of the 2 drugs (3Pt3G) before Annexin-V staining was analyzed by flow cytometry (*, P < 0.05 between the drug combination and each inhibitor alone). D, combined BRAF/PI3K inhibitor treatment blocks the escape of 1205Lu cells (PTEN) from therapy. Spheroids of 1205Lu cells were treated with either PLX4720 alone (3 and 10 μmol/L: data shows 3 mmol/L), LY294002 (10 μmol/L) alone or a combination of the 2 drugs for 72 hours. In other studies, spheroids were treated with drugs for 72 hours and then allowed to recover for 120 hours. Micrograph shows viability staining (green= live cells, red= dead cells). Magnification 10×.

    Cancer Res 2011 71, 2750-2760. Pictilisib (GDC-0941) purchased from Selleck.

    Combination of rapamycin and PI-103 leads to the suppression of AKT phosphorylation (phospho-specific western blot). Mel-Juso and 518A2 cells were treated with GDC-0941 from 0.05–1 μmol/L alone and in combination with rapamycin (50 nmol/L) for 24 hours. Control treatment was with DMSO.

     

     

    J Inves Der 2010 131, 495-503. Pictilisib (GDC-0941) purchased from Selleck.

  • Growth inhibition induced by the FGFR inhibitor BGJ398 and the PI3K inhibitors alone or in combination. AN3CA (A-C), JHUEM2 (D-F) and MFE296 (G-I) cells were treated with the indicated doses of BGJ398, GDC-0941 a n d BYL719 alone or in combination for 96 hours and an Sulforhodamine B (SRB) assay was subsequently performed. Data are presented as a percentage of the control, in which cells were treated with 0.1% (v/v) DMSO. Points represent the mean of three independent experiments (each performed in triplicate). Error bars represent the standard error of the mean (SEM) and lines were fitted using non-linear regression analysis. Interaction of BGJ398 and GDC-0941(redcircles) or BYL719(blacksquares) in AN3CA(C), JHUEM2(F) and MFE296(I). Median effect analysis was used to evaluate the interaction between the inhibitor combinations. Horizontal dotted lines indicate the boundaries for each interaction classification.

    Mol Cancer Ther, 2017.. Pictilisib (GDC-0941) purchased from Selleck.

    TGF-β induces mTORC2 activation. ( A ) NMuMG cells were treated with TGF-β for the indicated times before lysis and immunoblotting. (B ) NMuMG cells were treated or not with TGF-β for the indicated times, in the presence or absence of SB431542 or LY294002. Cell lysates were subjected to anti-Rictor immunoprecipitation, and the immunoprecipitates were subjected to in vitro kinase assays using kinase-inactive Akt1 as a substrate, before immunoblotting of the kinase reactions, immunoprecipitates and cell lysates. The left panels are from the same gel, without differential exposure. ( C ) NMuMG cells were treated or not with TGF-β or insulin for the indicated times, in the presence or absence of SB431542 or GDC-0941. The kinase activity of mTORC2 was then assessed as in B. The top panels are from the same gel, without differential exposure. (D) NMuMG cells were treated or not with TGF-β for the indicated times, in the presence or absence of SB431542 or LY294002. Cell lysates were subjected to immunoprecipitation using Rictor antibody, and/or immunoblotted.

    J Cell Sci 2012 125(Pt 5), 1259-73. Pictilisib (GDC-0941) purchased from Selleck.

  • Effects of LY294002 and GDC-0941 on the high-glucose-induced plasma membrane translocation of DGK δ1. (A, C) HEK293 cells were transfected with pAcGFP-DGKδ1 or pAcGFP-C1 vector. After being glucose-starved for 2.5 h and the subsequent pretreatment with (A) 10 μM LY294002 (Sigma-Aldrich) or (C) 1 μM GDC-0941 (Selleck Chemicals) for 30 min, the cells were incubated with or without high glucose (25 mM) for 5 min. The cells were fixed with 3.7% formaldehyde and observed using confocal laser-scanning microscopy. Scale bar = 10 μm. (B, D) After treatment with (B) LY294002 or (D) GDC-0941, the percentages of cells exhibiting the translocation of AcGFP-tagged DGK δ 1 to the plasma membrane were scored. More than 20 cells ex-pressing AcGFP-tagged DGK δ1 were counted in each experiment. The results are the means ± S.D. of three independent experiments. The statistical significance was deter-mined using Student's t -test (** P < 0.01, *** P < 0.005)

    Biochim Biophys Acta 2012 1823, 2210-6. Pictilisib (GDC-0941) purchased from Selleck.

    After starved in serum-free medium for 24h, Breast cancer cells incubated with the indicated concentrations of GDC-0941  for 3h,followed by 15-minute  stimulation of 100ng/ml EGF.

     

     

     

    Dr. Zhang of Tianjin Medical University. Pictilisib (GDC-0941) purchased from Selleck.

  • We treated all of drugs in T47D which has a PI3KCA H1044R mutation with the concentration shown below for 1 hour and performed western blot analysis using antibodies to phospho-AKT(SERINE 472), and total AKT.

     

     

    Saraswati Sukumar of Johns Hopkins University School of Medicine. Pictilisib (GDC-0941) purchased from Selleck.

     

    PI3K pathway signaling in GDC-0941 and MK-2206 treated MCF-7 derivatives with PIK3CA or  AKT1 mutations. Cells were grown in medium containing 5% FBS and treated with vehicle or increasing concentrations of GDC-0941 (0 nM, 50 nM, 100 nM, and 400 nM) or MK-2206 (0 nM, 100 nM, 250 nM, 1000 nM). After 24 hours of drug treatment, lysates were prepared and equal amounts of protein were load ed onto SDS-PAGE gels and blotted with the indicated antibodies.

    Pictilisib (GDC-0941) purchased from Selleck.

Purity & Quality Control

Choose Selective PI3K Inhibitors

Biological Activity

Description Pictilisib (GDC-0941) is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM in cell-free assays, with modest selectivity against p110β (11-fold) and p110γ (25-fold). Phase 2.
Targets
p110α [1]
(Cell-free assay)
p110δ [1]
(Cell-free assay)
p110β [1]
(Cell-free assay)
p110γ [1]
(Cell-free assay)
mTOR [1]
(Cell-free assay)
3 nM 3 nM 33 nM 75 nM 0.58 μM(Ki app)
In vitro

GDC-0941 is equipotent against PI3Kα and PI3Kδ as well as PI3Kα mutants E545-K and H1047-R, displaying modest levels of selectivity against PI3Kβ (10-fold) and PI3Kγ (25-fold), and greater levels of selectivity against members of PI3K class II, III, and IV, including C2β, Vps34, DNA-PK, and mTOR. GDC-0941 potently inhibits the phosphorylation of Akt in U87MG, PC3, and MDA-MB-361 cells with IC50 of 46 nM, 37 nM, and 28 nM, respectively. GDC-0941 inhibits the proliferation of U87MG, A2780, PC3, and MDA-MB-361 cells with IC50 of 0.95 μM, 0.14 μM, 0.28 μM, and 0.72 μM, respectively. [1] GDC-0941 treatment potently inhibits the proliferation of both trastuzumab-sensitive and -insensitive HER2-amplified cells with IC50 of 149-944 nM. GDC-0941 inhibits proliferation of HER2-amplified cells that harbor PIK3CA mutations with IC50 of <500 nM, and effectively inhibits both proliferation and viability of HER2-amplified breast cancer cells that are resistant to trastuzumab due to PTEN loss. [2] GDC-0941 significantly inhibits the growth of HCT116, DLD1 and HT29 cells with GI50 of 1081 nM, 1070 nM and 157 nM, respectively. [3] GDC-0941 inhibits tumor cell proliferation, induces apoptosis and suppresses centroblast population. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Sf9 NHzmO4FMcW6jc3WgRZN{[Xl? NGeyV5IyKGh? MonkSG1UVw>? NIO2fFVKdmirYnn0bY9vKG:oIHj1cYFvKHKnY3;tZolv[W62IGDJN2sheDFzMHTlcJRiKGW6cILld5Nm\CCrbjDT[lkh[2WubIOgZ49mgHC{ZYPzbY5oKHB6NXHsdIhiKHerdHigTWM2OCCxZjCwMlAxOyEQvF2= NW\kfWN1OTh5NUS2OVQ>
Sf9 MX7LbY5ie2ViQYPzZZk> MWmxJIg> NFjwV|RFVVOR MWjJcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KFCLM1ugdFEyOGKndHGgTFExPDdvUjDteZRidnRiZYjwdoV{e2WmIHnuJHNnQSClZXzsd{Bkd2W6cILld5NqdmdicEi1ZYxxcGFid3n0bEBKSzVyIH;mJFAvODB|IN88US=> NX3PN5k1OTh5NUS2OVQ>
Sf9 NFPTZYVMcW6jc3WgRZN{[Xl? Mor0NUBp M1LVbmROW09? MonJTY5pcWKrdHnvckBw\iCqdX3hckBz\WOxbXLpcoFvfCCSSUPLJJAyOTCkZYThJGU2PDVvSzDteZRidnRiZYjwdoV{e2WmIHnuJHNnQSClZXzsd{Bkd2W6cILld5NqdmdicEi1ZYxxcGFid3n0bEBKSzVyIH;mJFAvODB|IN88US=> MX[xPFc2PDZ3NB?=
Sf9 Mlr3T4lv[XOnIFHzd4F6 NYL6UlAzOSCq NEjEZWhFVVOR MYTJcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KFCLM1ugdFEyOGKndHGg[ZhxemW|c3XkJIlvKFOoOTDj[YxteyClb3X4dJJme3OrbnegdFg2[WyyaHGge4l1cCCLQ{WwJI9nKDBwMEOzJO69VQ>? NYXrSZg4OTh5NUS2OVQ>
Sf9 NVXkPWI2U2mwYYPlJGF{e2G7 NGTjW3AyKGh? MUHEUXNQ MlHrTY5pcWKrdHnvckBw\iCqdX3hckBz\WOxbXLpcoFvfCCSSUPLJJAyOTCjbIDoZUBmgHC{ZYPz[YQhcW5iU3[5JINmdGy|IHPv[ZhxemW|c3nu[{BxQDWjbIDoZS=> MkDHNVg4PTR4NUS=
MDA-MB-361 MWnGeY5kfGmxbjDBd5NigQ>? Mke4NkBp NIXkXYxFVVOR MlO2TY5pcWKrdHnvckBw\iCDa4SgV4VzPDd|IIDoc5NxcG:{eXzheIlwdiCrbjDoeY1idiCPRFGtUWIuOzZzIHPlcIx{KHerdHigVGlMO0ODIFW1OFUuUyCvdYTheIlwdiC5aYToJGlEPTBib3[gNE4xOjhizszN NFTSNpIyQDd3NE[1OC=>
PC3 NWfYWWNITnWwY4Tpc44hSXO|YYm= MYOyJIg> NFjOZ|FFVVOR MYfJcohq[mm2aX;uJI9nKEGtdDDT[ZI1PzNicHjvd5Bpd3K7bHH0bY9vKGmwIGDUSW4udnWubDDoeY1idiCSQ{OgZ4VtdHNid3n0bEBKSzVyIH;mJFAvODN5IN88US=> NEHkVZYyQDd3NE[1OC=>
U87MG M1TnOmZ2dmO2aX;uJGF{e2G7 NVWySGpiOiCq NHq0V5dFVVOR MXPJcohq[mm2aX;uJI9nKEGtdDDT[ZI1PzNicHjvd5Bpd3K7bHH0bY9vKGmwIGDUSW4udnWubDDoeY1idiCXOEfNS{Bk\WyuczD3bZRpKEmFNUCgc4YhOC5yNE[g{txO NInucYUyQDd3NE[1OC=>
MDA-MB-361 M1LQRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NInnRpo6PiCq NXPWZ5dqTE2VTx?= MYrBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2GQT3NRk0{PjFiY3XscJMhf2m2aDDQTWs{S0FiRUW0OU1MKG23dHH0bY9vKHerdHigTWM2OCCxZjCwMlczKM7:TR?= M3\rdFE5PzV2NkW0
A2780 NYjBfoE2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mmm1PVYhcA>? NUj2S4U6TE2VTx?= NUXUeFQ3SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDBNlc5OCClZXzsd{B4cXSqIGDJT|NESSCjbnSgVHRGViCvdYTheIlwdiC5aYToJGlEPTBib3[gNE4yPCEQvF2= NGDjU|gyQDd3NE[1OC=>
PC3 NEnYSldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWS2XWF{QTZiaB?= M1XqeWROW09? NHH2T4FKSzVyPUCuNlgh|ryP NYrwTYdJOTh5NUS2OVQ>
U87MG NGj0ZXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUW5OkBp NH:4SGJFVVOR M1faXWlEPTB;MD65OUDPxE1? M{\rN|E5PzV2NkW0
Sf9 NXPmZ5UzU2mwYYPlJGF{e2G7 NX:3OXhLOzBibXnu MmfCSG1UVw>? M4H4eWlvcGmkaYTpc44hd2ZiaIXtZY4hWEl|S3fhcY1iKGW6cILld5Nm\CCjc4Pld5Nm\CCjczDhcY92dnRib3[gRXRRKGOxboP1cYVlKHerdHigTWM2OCCxZjCwMlA1OiEQvF2= Ml\TNlI2PDh|NEK=
RAW 264.7 MmfXT4lv[XOnIFHzd4F6 NYmyW5dUQTBibXnu MnHxSG1UVw>? NGC5S2pKdmirYnn0bY9vKG:oIHj1cYFvKFCLM1vnZY1u[SCneIDy[ZN{\WRiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCDS2SgdIhwe3Cqb4L5cIF1cW:wIIfpeIghUUN3MDDv[kAxNjJ7ODFOwG0> M4Sw[VIzPTR6M{Sy
Sf9 NHvOe5RMcW6jc3WgRZN{[Xl? M1nFVFEhcA>? NEWxZ49KdmirYnn0bY9vKG:oIFfTWE1nfXOnZDDoeY1idiC{ZXPvcYJqdmGwdDDQTVNM[mW2YTDlfJBz\XO|ZXSgbY4h[mGldXzveolzfXNiaX7m[YN1\WRiU1[5JINmdGy|IIfpeIghUUN3MDDv[kAxNjBzNzFOwG0> NIXae|EzOzV2ME[0OS=>
Sf9 NVHBbGFCU2mwYYPlJGF{e2G7 M3\PfVEhcA>? NXHxWnBbUW6qaXLpeIlwdiCxZjDHV3Qu\nW|ZXSgbJVu[W5icnXjc41jcW6jboSgVGk{U2SnbIThJIV5eHKnc4Pl[C=> M3S2R|I{PTRyNkS1
Sf9 MVrLbY5ie2ViQYPzZZk> NHrUfpQyKGh? MVPJcohq[mm2aX;uJI9nKEeVVD3meZNm\CCqdX3hckBz\WOxbXLpcoFvfCCSSUPL[4FudWFiZYjwdoV{e2Wm NXTKfVJmOjN3NEC2OFU>
Sf9 MnLlT4lv[XOnIFHzd4F6 NIfQdnAyKGh? M4H1TGlvcGmkaYTpc44hd2ZiR2PUMYZ2e2WmIHj1cYFvKHKnY3;tZolv[W62IGDJN2tidHCqYTDlfJBz\XO|ZXS= MonzNlM2PDB4NEW=
SKOV3 MoXET4lv[XOnIFHzd4F6 M4H6fVEh|ryP M4n2OVEhcA>? MlvYSG1UVw>? NXzzO29lUW6qaXLpeIlwdiCxZjDQTVNM[WyyaHGgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDBb5QhW2W{NEezJJBpd3OyaH;yfYxifGmxbh?= NV\vTGh7OjN|NkCzOFg>
MCF7 MkHoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV2xJO69VQ>? NUC0O5loQTZiaB?= MnjjSG1UVw>? M3;FbGdKPTB;MD6wO|AzKM7:TR?= M1Hl[|I{OzZyM{S4
SKOV3 MkLzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUDNfI1[OSEQvF2= M3\Eflk3KGh? MUTEUXNQ MlG0S2k2OD1yLkG0O|Yh|ryP NV:wSGFvOjN|NkCzOFg>
PC3 NHPoWIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\1cllrPzJiaB?= NH\HZVlFVVOR MU\JR|UxRTBwMkig{txO MXyyNVk5OTdzNB?=
MCF7.1 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3vjclczKGh? MXTEUXNQ MV;BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2FRkeuNUBk\WyuczDlfJBz\XO|aX7nJGhGWjJiZ3Xu[UB4cXSqIFnDOVAhd2ZiMD6yPEDPxE1? MoLINlE6QDF5MUS=
MCF7-neo/Her2 M4rQNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkGyO|IhcA>? MWrEUXNQ M{naeWlEPTB;MD6yPUDPxE1? NWT2c2NGOjN4NkK5NFM>
MCF7-neo/Her2 NFrt[YxMcW6jc3WgRZN{[Xl? MYXJcohq[mm2aX;uJI9nKFCLM1vhcJBp[SCjc4Pld5Nm\CCjczDy[YR2[3Srb36gc4YhSUuWIIDoc5NxcG:{eXzheIlwdiCjdDDTOFc{KHerdHigTWM2OCCxZjCwMlAxPyEQvF2= MnzUNlM3PjJ7MEO=
PC3 M37xeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUW3NkBp MV\EUXNQ MUTFR|UxRTBwM{Sg{txO M2jmb|IyQTh3NkO5
MCF7.1 MkPkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWq3NkBp M4jIZWROW09? MkfBRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPQ1[3MlEh[2WubIOg[ZhxemW|c3nu[{BRUTONYXzwbIEhdXW2YX70JJdqfGhiRVO1NEBw\iByLkO5JO69VQ>? NV;jVodVOjF7OEW2N|k>
PC3 M2OyOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn7pO|IhcA>? M2iycmROW09? NImySZBCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGDDN{Bk\WyuczDk[YZq[2mnboSgbY4hWFSHTjD3bZRpKEmFNUCgc4YhOC5|OTFOwG0> MljyNlAxPTB4Nkm=
MCF7.1 NWDXdldnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUC3NkBp NVrLPGc{TE2VTx?= MmjvRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPQ1[3MlEh[2WubIOg[ZhxemW|c3nu[{BRUTONYXzwbIEhdXW2YX70JJdqfGhiSVO1NEBw\iByLkO0JO69VQ>? NHTOc48zODB3ME[2PS=>
MCF7.1 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mmm0O|IhcA>? NGjzcHhGSzVyPUCuO|Ih|ryP NWjPc3ZqOjB|NE[2OVY>
NCI-H1975 MnHlR5l1d3SxeHnjJGF{e2G7 MmrLO|IhcA>? M{TFZmlEPTB;MD6yO{DPxE1? MVKyN|A2QTV2NR?=
H460 M1LFW2N6fG:2b4jpZ{BCe3OjeR?= MVW3NkBp M1zidWlEPTB;MD64O{DPxE1? NF;MNokzOzB3OUW0OS=>
HT-29 MlHwR5l1d3SxeHnjJGF{e2G7 NGTNUmk4OiCq NYDNb4Z2UUN3ME2wMlY3KM7:TR?= NWDjXY1iOjNyNUm1OFU>
HepG2 Mlz5R5l1d3SxeHnjJGF{e2G7 NEDqS4g4OiCq MknKTWM2OD1zIN88US=> NEnXOFczOzB3OUW0OS=>
SGC7901 Mmq4R5l1d3SxeHnjJGF{e2G7 Ml\0O|IhcA>? MWLJR|UxRTFwODFOwG0> MlTTNlMxPTl3NEW=
NCI-H226 MWfDfZRwfG:6aXOgRZN{[Xl? M2n6NFczKGh? MYLJR|UxRTJwOTFOwG0> NWi3ZpNvOjNyNUm1OFU>
A549 NFjQ[|BEgXSxdH;4bYMhSXO|YYm= M3X1eFczKGh? MYjJR|UxRTZwOTFOwG0> NF\WeY0zOzB3OUW0OS=>
U87MG NGLTdJNEgXSxdH;4bYMhSXO|YYm= MlPGO|IhcA>? NUX0bHQ5UUN3ME23Mlc4KM7:TR?= MoDtNlMxPTl3NEW=
HBC4 NWXCcnFVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFzZ[Yltd2eJSUWwQU03NjB|IF2= NFTaTnYzOjN|NkK0Oi=>
BSY1 Mln2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVqxcItKdG:pR1m1NF0uPi57MDDN NFrDelIzOjN|NkK0Oi=>
HBC5 NYjkOmV3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2PDc4xw\0eLNUC9MVYvPjBiTR?= NHvOXpQzOjN|NkK0Oi=>
MCF7 M3Ly[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlLEcI9oT0l3ME2tO{4{OyCP NGD0S44zOjN|NkK0Oi=>
MDA-MB-231 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYH3UGZVdG:pR1m1NF0uPS52NjDN MXyyNlM{PjJ2Nh?=
U251 MorsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYXOU2tmdG:pR1m1NF0uPS53MDDN MUOyNlM{PjJ2Nh?=
SF268 NUHTTXpTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEfPSlZtd2eJSUWwQU02NjN7IF2= MlzoNlI{OzZ{NE[=
SF295 MmTzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoXtcI9oT0l3ME2tOk4{PyCP MoK4NlI{OzZ{NE[=
SF539 MoTFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF7LV|Ftd2eJSUWwQU03NjVyIF2= M3HJdlIzOzN4MkS2
SNB75 MnHrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mkm2cI9oT0l3ME2tO{4yOCCP M1X3WFIzOzN4MkS2
SNB78 M3e3Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4jHT4xw\0eLNUC9MVYvPTJiTR?= MlHnNlI{OzZ{NE[=
HCC2998 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjvOlNtd2eJSUWwQU03NjJ7IF2= MWSyNlM{PjJ2Nh?=
KM12 NV35b4VsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;sc4dIUTVyPT21Mlc3KE1? MmT3NlI{OzZ{NE[=
HT-29 NIDNWllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlXIcI9oT0l3ME2tOk4{OCCP MYCyNlM{PjJ2Nh?=
HCT15 MkLiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnXDcI9oT0l3ME2tOk4yOiCP MnnCNlI{OzZ{NE[=
HCT116 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\vXWdtd2eJSUWwQU02Njh5IF2= MXKyNlM{PjJ2Nh?=
NCI-H23 MnLvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVjlepNSdG:pR1m1NF0uPS55MzDN M1jpfFIzOzN4MkS2
NCI-H226 MkTZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3sc4dIUTVyPT22MlIyKE1? NIizbWczOjN|NkK0Oi=>
NCI-H522 M3nKSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYHidFJEdG:pR1m1NF0uPi53ODDN MorrNlI{OzZ{NE[=
NCI-H483 M2PrOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXPkWJNKdG:pR1m1NF0uPi53NjDN MlHoNlI{OzZ{NE[=
A549 M3LEcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlrPcI9oT0l3ME2tOk4yPSCP MlH4NlI{OzZ{NE[=
DMS273 NGXSUWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\NcI9oT0l3ME2tOk41OyCP MlL1NlI{OzZ{NE[=
DMS114 M1r4Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3PINoxw\0eLNUC9MVUvQTJiTR?= M2nNN|IzOzN4MkS2
LOXIMVI MlfRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPsc4dIUTVyPT22MlI6KE1? NH;xbWszOjN|NkK0Oi=>
OVCAR3 Mo[yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlTZcI9oT0l3ME2tOk44OSCP NGf2RnUzOjN|NkK0Oi=>
OVCAR4 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXsc4dIUTVyPT21Mlc3KE1? MnXyNlI{OzZ{NE[=
OVCAR5 NXj0[WtOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\sc4dIUTVyPT22MlI3KE1? M1zqO|IzOzN4MkS2
OVCAR8 M2rOOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2HDfIxw\0eLNUC9MVUvPzNiTR?= Ml62NlI{OzZ{NE[=
SKOV3 NIj0WlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTsc4dIUTVyPT22MlUzKE1? NGL4dVkzOjN|NkK0Oi=>
RXF631L MoT4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M17ufYxw\0eLNUC9MVYvQDhiTR?= NVLhS5RiOjJ|M{[yOFY>
ACHN MkLQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1;URoxw\0eLNUC9MVYvODdiTR?= NVPodWNGOjJ|M{[yOFY>
St-4 NFTKOnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPsc4dIUTVyPT21MlU3KE1? MXiyNlM{PjJ2Nh?=
MKN1 MlLHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYf2elZzdG:pR1m1NF0uPy5yODDN NF\adVMzOjN|NkK0Oi=>
MKN7 M2roVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnPOcI9oT0l3ME2tOk42OCCP M1fCO|IzOzN4MkS2
MKN28 NWTZUmZZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkLNcI9oT0l3ME2tOU42OiCP NELxeXkzOjN|NkK0Oi=>
MKN45 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUnkcY5LdG:pR1m1NF0uPi53NTDN Mlf4NlI{OzZ{NE[=
MKN74 M2fmcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGLYfIptd2eJSUWwQU03NjB{IF2= NUDFUXNOOjJ|M{[yOFY>
DU145 MnfKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH7XXIhtd2eJSUWwQU02Njh3IF2= M4XFWFIzOzN4MkS2
PC3 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIe0UFhtd2eJSUWwQU03NjZ4IF2= MlXGNlI{OzZ{NE[=
ES5 M3G0XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUOwb|ZZUUN3ME21NE4zOSCwTR?= NGnZRnBUSU6JRWK=
HH MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrJcnRNUUN3ME2xNVEvODhibl2= MVPTRW5ITVJ?
MHH-PREB-1 MonsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnPSTWM2OD1zMUSuN{BvVQ>? NGDsfGJUSU6JRWK=
NCI-H1770 MlTFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn;HTWM2OD1zMkOuPFYhdk1? NHrnRZFUSU6JRWK=
HuO9 NWi0fndoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn7pTWM2OD1{ME[uNFIhdk1? M2nydHNCVkeHUh?=
HAL-01 M1TTOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIL6OVhKSzVyPUKwOk44OyCwTR?= M13VSHNCVkeHUh?=
NOS-1 NVGwN3RVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGX0dZVKSzVyPUKxNU45OiCwTR?= Mmn4V2FPT0WU
HGC-27 NGL6bmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTJzMj61O{BvVQ>? MkfoV2FPT0WU
NB69 MkSwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWGzeWtmUUN3ME2yOFUvOjdibl2= NFLwVINUSU6JRWK=
RS4-11 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\ZZ21[UUN3ME2yOlEvPzZibl2= NWe3eIZ[W0GQR1XS
DOK NFLRWFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzOWotuUUN3ME2zNFEvPyCwTR?= M4e5THNCVkeHUh?=
LB2241-RCC MnfpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MljHTWM2OD1|MEOuPFQhdk1? MXvTRW5ITVJ?
NCI-H1623 NG\Ic2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mly4TWM2OD1|MESuNFghdk1? NHqyXHZUSU6JRWK=
YH-13 NVHiU45YT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYfWWHFIUUN3ME2zNFQvOzJibl2= MVjTRW5ITVJ?
BPH-1 NY[1W5l2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX:wS5JJUUN3ME2zNVQhdk1? MYHTRW5ITVJ?
AN3-CA M33QTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXX6XXNZUUN3ME2zOFAvOzdibl2= NYLFNHI6W0GQR1XS
ES7 NH3WZ3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2PycWlEPTB;M{SxMlk6KG6P M{XlfnNCVkeHUh?=
MDA-MB-175-VII M3P5N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVWwZ4syUUN3ME2zOVIvQTJibl2= MoToV2FPT0WU
GAMG NX7MRoh7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXHufohJUUN3ME2zO|AvQDVibl2= MUPTRW5ITVJ?
CHL-1 Ml;iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEfyPZRKSzVyPUO3PE43PSCwTR?= NHnZRldUSU6JRWK=
NB7 Ml\QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nQc2lEPTB;M{i5Mlg{KG6P M4fvfHNCVkeHUh?=
MFE-280 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPxWXpsUUN3ME20NVgvOiCwTR?= NYPlUlROW0GQR1XS
HL-60 NVjGTGc6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2HINWlEPTB;NEK1Mlc2KG6P MUnTRW5ITVJ?
GCIY NIq1OYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYmyTWxwUUN3ME20N|MvQCCwTR?= MWLTRW5ITVJ?
MDA-MB-361 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1S4OGlEPTB;NEO5MlE{KG6P MkHQV2FPT0WU
LXF-289 M1ixT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4Da[GlEPTB;NES4MlI4KG6P Mk\EV2FPT0WU
NBsusSR M3fUSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRTR6OD64OUBvVQ>? MoHhV2FPT0WU
KU-19-19 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGe2WoZKSzVyPUWxOk4xPyCwTR?= M4LFPHNCVkeHUh?=
A204 M{LFWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MULJR|UxRTV{Mj6zN{BvVQ>? NI\Bb2lUSU6JRWK=
LB1047-RCC MmXNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPqbXhFUUN3ME21NlIvQTNibl2= MYHTRW5ITVJ?
COLO-684 NX\JWllIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmLOTWM2OD13MkOuNVEhdk1? MV7TRW5ITVJ?
PA-1 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3jvPWlEPTB;NUOyMlQyKG6P MVLTRW5ITVJ?
MG-63 MoXMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTV2MT6xNUBvVQ>? M1S3OnNCVkeHUh?=
BHT-101 NV\EZmdtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHHpTI9KSzVyPUW0OE46PCCwTR?= NILBNFdUSU6JRWK=
NKM-1 M1Lyd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\MSmRFUUN3ME21PVMvODlibl2= MnL6V2FPT0WU
T47D M2jiTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTV7Nz61OkBvVQ>? NHfD[|dUSU6JRWK=
MOLT-4 MnWyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGXqdG9KSzVyPU[yN{43OiCwTR?= MknvV2FPT0WU
IGROV-1 NFnIOI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkHmTWM2OD14M{SuN|Ehdk1? NGHJV5ZUSU6JRWK=
ES4 NFjiOHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmToTWM2OD14M{muOVQhdk1? M4XLSnNCVkeHUh?=
HuO-3N1 M{DzdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHrEOYNKSzVyPU[0Nk4{QCCwTR?= MXvTRW5ITVJ?
NEC8 M2XlW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoG1TWM2OD14NUOuOVchdk1? M3u4T3NCVkeHUh?=
HO-1-N-1 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoCyTWM2OD14NUmuNVchdk1? NWDvcJk{W0GQR1XS
EPCL-272H MknGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVTJbpFHUUN3ME22PFcvOjFibl2= NHfQWYNUSU6JRWK=
D-263MG NHnVTlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1K3d2lEPTB;N{G4MlEhdk1? MniyV2FPT0WU
MV-4-11 NHPvemlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYLlV5FmUUN3ME23NlQvOzFibl2= M2nORnNCVkeHUh?=
SK-NEP-1 MlHYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUXob3pmUUN3ME23NlUvQTRibl2= M4Htb3NCVkeHUh?=
SW872 NGLZRohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmP2TWM2OD15MkeuPFkhdk1? M2PoTHNCVkeHUh?=
P30-OHK NFixS2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWq3U4t{UUN3ME23N|AvPzFibl2= MXzTRW5ITVJ?
OMC-1 Mli4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHJR|UxRTd3MT6wPUBvVQ>? MXTTRW5ITVJ?
LoVo M1OwbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml\rTWM2OD15N{euPUBvVQ>? MUPTRW5ITVJ?
LNCaP-Clone-FGC NYm0PYJsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2TFXGlEPTB;N{m2MlM1KG6P MnS4V2FPT0WU
L-363 MkTKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkfxTWM2OD15OUiuOFIhdk1? NX;pcVc5W0GQR1XS
ES8 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEjSenVKSzVyPUixNE42OiCwTR?= NHPjPIFUSU6JRWK=
697 NXO4XVM{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M32zTGlEPTB;OEOxMlU2KG6P NIrwOHBUSU6JRWK=
HSC-3 Mn3WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4rTfWlEPTB;OEO5MlU1KG6P Ml[yV2FPT0WU
H4 NUO0VHNrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4\xdWlEPTB;OEWwMlg2KG6P NIDybHFUSU6JRWK=
QIMR-WIL NXnBXoJrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NILZWVJKSzVyPUi2OU4zKG6P MlK3V2FPT0WU
OAW-42 MnfqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTh5Mj6xPUBvVQ>? MYDTRW5ITVJ?
MCF7 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmDnTWM2OD16OUiuOVkhdk1? NHvWU5pUSU6JRWK=
SCC-25 NHGwdm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVXZXJU3UUN3ME25NVQvOTlibl2= Mn3PV2FPT0WU
NCI-H1563 NIewU3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\XS5JKSzVyPUmxOU46QSCwTR?= MmHxV2FPT0WU
OVCAR-5 NXPvR|JwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4LVe2lEPTB;OUSwMlE4KG6P M3vtdnNCVkeHUh?=
HDLM-2 NUX6cpBKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTl2OT6yJI5O NUDZNFVTW0GQR1XS
NB5 M3uzW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVzCZYRnUUN3ME25OVYvPiCwTR?= NHTWOFlUSU6JRWK=
NCI-H292 MlHjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFjIO49KSzVyPUm3OE4{OiCwTR?= Mnf0V2FPT0WU
A101D MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;tOlFKSzVyPUm5NE4yQSCwTR?= MX\TRW5ITVJ?
NCI-H1648 NE\nSFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTl7OD61NUBvVQ>? NVfwZmljW0GQR1XS
EKVX NX\iXYN[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWfzflJjUUN3ME2xMlAyOjlizszN NHzCNplUSU6JRWK=
SW1710 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVPqeYw2UUN3ME2xMlA1OjN|IN88US=> M3TIWHNCVkeHUh?=
WM-115 MoPsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVTRfWNzUUN3ME2xMlA3PjV4IN88US=> MkntV2FPT0WU
CAL-54 M{nj[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGjv[2dKSzVyPUGuNFcxQDFizszN M3Sx[3NCVkeHUh?=
TGBC24TKB Mkj0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1PTN2lEPTB;MT6wPFA1PSEQvF2= MWjTRW5ITVJ?
NCI-H520 NHu5fG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUO0fm45UUN3ME2xMlA5QTZ5IN88US=> MXzTRW5ITVJ?
D-423MG MnXGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1WxbGlEPTB;MT6wPVk3OiEQvF2= MX;TRW5ITVJ?
BFTC-905 MoXDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoHmTWM2OD1zLkGzOFQ6KM7:TR?= MorrV2FPT0WU
HT Mki1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlPXTWM2OD1zLkGzOFc5KM7:TR?= Mn7VV2FPT0WU
CTB-1 NEnpbopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX7iR|loUUN3ME2xMlE1Ojl|IN88US=> NGLTdmNUSU6JRWK=
Hs-578-T MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYrZNphNUUN3ME2xMlE6PTZ3IN88US=> NYDHNZdWW0GQR1XS
HuH-7 Mn;xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVi3OpFwUUN3ME2xMlIxQTR7IN88US=> NXfYNFNFW0GQR1XS
LB996-RCC MmPvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4[5NGlEPTB;MT6yNlE4PyEQvF2= MlPDV2FPT0WU
KYSE-270 NVTzXXJKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTFwMkm3N|Qh|ryP Mof5V2FPT0WU
A4-Fuk MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF\sVXVKSzVyPUGuNlk6QTNizszN MmG4V2FPT0WU
A498 M33Y[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M17H[WlEPTB;MT6zNFQ4PCEQvF2= Mk\uV2FPT0WU
SK-MEL-1 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkjXTWM2OD1zLkOwOlc6KM7:TR?= M2L2[HNCVkeHUh?=
AU565 M1PPNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3jOVWlEPTB;MT6zNVg3OyEQvF2= M4Lu[XNCVkeHUh?=
Saos-2 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUC3TXNHUUN3ME2xMlM{OjB3IN88US=> NHW1NZpUSU6JRWK=
A549 NXT1THExT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHHDcFlKSzVyPUGuN|k6PyEQvF2= Mn7xV2FPT0WU
BFTC-909 MkPBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7jTWM2OD1zLkSzN|A2KM7:TR?= MVTTRW5ITVJ?
MDA-MB-415 NXT5bXp7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHfzZm1KSzVyPUGuOFg3QTJizszN M2fJNXNCVkeHUh?=
639-V Mn;4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4jGNWlEPTB;MT61NFI1PSEQvF2= NHvmdJJUSU6JRWK=
A704 NX;OXI15T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEPlWVRKSzVyPUGuOVA4QDVizszN M3izOnNCVkeHUh?=
PANC-03-27 NVfE[IVHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3flW2lEPTB;MT61NVQxQCEQvF2= NHrCPZBUSU6JRWK=
SK-MEL-28 NEL5SZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn3XTWM2OD1zLkW2NFg2KM7:TR?= MVzTRW5ITVJ?
Ramos-2G6-4C10 NIj3bWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlX3TWM2OD1zLk[wO|Q3KM7:TR?= NF7FfnhUSU6JRWK=
HuP-T4 NVjucmxuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MonlTWM2OD1zLk[wO|c5KM7:TR?= NWTCVldXW0GQR1XS
VA-ES-BJ NXvRR5FzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXG0bW1IUUN3ME2xMlYyOjdizszN M1r6cnNCVkeHUh?=
EFM-19 NUmxZmQ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NILETmpKSzVyPUGuOlE5OSEQvF2= Ml7EV2FPT0WU
G-401 MoHXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4XpfGlEPTB;MT62NlE3PCEQvF2= M{fxSXNCVkeHUh?=
D-566MG NGO4dWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4XMeWlEPTB;MT62NlU{KM7:TR?= NILFcYVUSU6JRWK=
JVM-3 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTFwNkS4O|Uh|ryP MXnTRW5ITVJ?
TK10 M4\pfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTFwNkewPFMh|ryP NV\PZpFPW0GQR1XS
BT-20 MkXYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTFwNki5NFIh|ryP MV\TRW5ITVJ?
EGI-1 M3LifWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jOWmlEPTB;MT64OFcxOSEQvF2= MXTTRW5ITVJ?
EW-16 NV7jVHJYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn3PTWM2OD1zLki1NVgzKM7:TR?= MUHTRW5ITVJ?
NCI-H2228 NFnUTmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHF[phuUUN3ME2xMlg2OjB|IN88US=> NGe3N3JUSU6JRWK=
BB49-HNC MnjxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7XTWM2OD1zLki4OlkzKM7:TR?= MUjTRW5ITVJ?
G-402 NGGxR2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTFwOEm3PVch|ryP NXGxRm4{W0GQR1XS
NCI-H526 NWrtW2ZJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWXWfHZjUUN3ME2xMlkyOzlizszN NVnUVWw4W0GQR1XS
ME-180 NFzJZ|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LLR2lEPTB;MT65N|Q4PyEQvF2= MkPiV2FPT0WU
PFSK-1 NG\0Um5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXHJR|UxRTFwOUS0OVgh|ryP MV3TRW5ITVJ?
TYK-nu NEHo[3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGS1fGNKSzVyPUGuPVU5OjNizszN NV3tN5NyW0GQR1XS
HOS NXf1Z4xiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\DTWM2OD1zLkm3PVQ5KM7:TR?= MVvTRW5ITVJ?
T98G MmfOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTFwOUmwNFYh|ryP MVjTRW5ITVJ?
SK-MES-1 NEi3WJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXfXZlVFUUN3ME2yMlAyOzN{IN88US=> M4S5[nNCVkeHUh?=
SNB75 MkD0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnnsTWM2OD1{LkCxOVQyKM7:TR?= MUDTRW5ITVJ?
LAMA-84 MlvyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnnVTWM2OD1{LkCyOlg6KM7:TR?= M3rFTHNCVkeHUh?=
CAL-39 M4Pmcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3W5Z2lEPTB;Mj6wN|I5KM7:TR?= M3\TT3NCVkeHUh?=
LOXIMVI NUjNdllST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnLnTWM2OD1{LkC0NFg1KM7:TR?= MmXnV2FPT0WU
NH-12 NHLLR25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkTXTWM2OD1{LkC1OFI1KM7:TR?= NULMZmhEW0GQR1XS
NCI-H1048 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTJwMUC1NkDPxE1? NFjqPHdUSU6JRWK=
KS-1 Mkj2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTJwMUGwNFEh|ryP NWKz[GtSW0GQR1XS
NCI-N87 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTJwMUOzPFQh|ryP NVz0XWdlW0GQR1XS
CHP-212 M3HVZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVnGZlZQUUN3ME2yMlE5PDR{IN88US=> MnHBV2FPT0WU
HCC1419 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkfiTWM2OD1{LkKxNVE2KM7:TR?= NVPyb2VjW0GQR1XS
ES1 MmjrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\s[|FyUUN3ME2yMlIyOzJ4IN88US=> NH7KWZJUSU6JRWK=
NCI-H2030 M1P1eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXi1[m9uUUN3ME2yMlI1OTJ|IN88US=> M3\iUHNCVkeHUh?=
EW-22 Mn6wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjEVIhKSzVyPUKuNlUxPjdizszN NX3QS|Q4W0GQR1XS
A431 MlnqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\ITWM2OD1{LkK3N|U1KM7:TR?= NF70V|hUSU6JRWK=
SF126 M2radmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVvJR|UxRTJwM{C2NlUh|ryP NYr2VolCW0GQR1XS
SF295 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{LRdmlEPTB;Mj6zNVUzPCEQvF2= M{DOcXNCVkeHUh?=
D-502MG NG\JcZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWGweZJzUUN3ME2yMlMzPDZzIN88US=> NVS5RZprW0GQR1XS
HCC2157 MlLXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NETtbVBKSzVyPUKuN|I6OjdizszN MWPTRW5ITVJ?
D-283MED M{XaU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn7YTWM2OD1{LkO1PVI3KM7:TR?= MV7TRW5ITVJ?
SNU-423 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlvETWM2OD1{LkSwNVcyKM7:TR?= NGH1TIZUSU6JRWK=
SK-LU-1 NX;XZ5Q{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTJwNES1PFYh|ryP MYnTRW5ITVJ?
22RV1 NH\Z[JJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYrYT|gzUUN3ME2yMlQ2PjF5IN88US=> MmjvV2FPT0WU
SW1088 NUTXWY5ZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWfKPIZXUUN3ME2yMlQ6OjF|IN88US=> MmfUV2FPT0WU
HT-3 NEmzbGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTJwNEmyOVkh|ryP NYGyV5F6W0GQR1XS
NCI-H1666 MkDKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nKcmlEPTB;Mj61NVExPCEQvF2= MUjTRW5ITVJ?
EM-2 M1HWZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3r2[GlEPTB;Mj61NVE3QSEQvF2= NGjsNW5USU6JRWK=
SNU-449 NVfFSVByT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjJR|UxRTJwNUewNVQh|ryP MYnTRW5ITVJ?
786-0 NIHjTZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzqXWZNUUN3ME2yMlU6OjN6IN88US=> MoDDV2FPT0WU
SKG-IIIa MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnu5TWM2OD1{Lk[1PVM6KM7:TR?= NWnTZ4s1W0GQR1XS
MEL-HO MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\DPWlEPTB;Mj62O|Y{PCEQvF2= M1XRXXNCVkeHUh?=
LCLC-97TM1 NGPYW5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTJwNkmyOlch|ryP M3:5eHNCVkeHUh?=
MKN7 M4jFeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{PVU2lEPTB;Mj63NFc2PCEQvF2= MXPTRW5ITVJ?
5637 NWficGtST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1fMRWlEPTB;Mj63NVA{PSEQvF2= NVP0d4RFW0GQR1XS
HOP-92 NH7Gb4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWnPPXBDUUN3ME2yMlc1PzF5IN88US=> MmrXV2FPT0WU
MDA-MB-157 NFX4c5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnTVTWM2OD1{LkiyNFI{KM7:TR?= MU\TRW5ITVJ?
NB12 MonpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYTJR|UxRTJwOES5NVQh|ryP MUfTRW5ITVJ?
DMS-273 M3r1bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1Pwe2lEPTB;Mj64OlQ4KM7:TR?= M3XOWHNCVkeHUh?=
HCC70 M{LrUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTJwOE[1PFkh|ryP NWjWNYJvW0GQR1XS
YKG-1 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NILiXlNKSzVyPUOuNFM4QDdizszN MnjiV2FPT0WU
NCI-H28 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlnDTWM2OD1|LkC1NlkyKM7:TR?= M3vDbXNCVkeHUh?=
HN NIW5OHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH7TNmtKSzVyPUOuNFY3OzZizszN MoKxV2FPT0WU
HT-1080 NV7UT3dRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFKzVItKSzVyPUOuNFg3ODZizszN MYnTRW5ITVJ?
HPAF-II NWLEfVlOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTNwMUCwOlgh|ryP NHjoOWFUSU6JRWK=
U-2-OS M1zDRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\XU4JbUUN3ME2zMlE{Pzh{IN88US=> Ml\BV2FPT0WU
SNU-387 MnuzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3H2fGlEPTB;Mz6xOlM3PCEQvF2= MVTTRW5ITVJ?
Becker M2TpWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnfnTWM2OD1|LkG2PFA5KM7:TR?= MmnrV2FPT0WU
BHY M{joS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWHJR|UxRTNwMkW1O|Eh|ryP M2nvOHNCVkeHUh?=
HTC-C3 M4Dqd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\zTWM2OD1|LkK5N|UzKM7:TR?= MV\TRW5ITVJ?
M14 NVO1fFhZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlWwTWM2OD1|LkOwOlY{KM7:TR?= MoDtV2FPT0WU
COR-L23 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXZenF2UUN3ME2zMlM4Ojd7IN88US=> NIDGPZFUSU6JRWK=
C32 NV7yVm9zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTNwNEG1NFgh|ryP NYK2W|FUW0GQR1XS
Mewo M3;IOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\Md2hVUUN3ME2zMlQzOTh{IN88US=> MXfTRW5ITVJ?
TE-8 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTNwNEiyOVkh|ryP MWTTRW5ITVJ?
RPMI-2650 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2LwNmlEPTB;Mz62NFY{PyEQvF2= NXX1OllJW0GQR1XS
AGS M3nMRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXXJSoNWUUN3ME2zMlYzPDZ2IN88US=> NEfwXXBUSU6JRWK=
MZ2-MEL MmP0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGnYcXNKSzVyPUOuOlYyOzhizszN Mm[3V2FPT0WU
Calu-3 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVHQbJRoUUN3ME2zMlcyOjh5IN88US=> MVjTRW5ITVJ?
SJSA-1 M2nCSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUf3WGpVUUN3ME2zMlcyOzF3IN88US=> MWfTRW5ITVJ?
SW962 NUPyXIFHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFjzXYNKSzVyPUOuO|I3OzZizszN MY\TRW5ITVJ?
PC-14 NX;HXJoyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTNwN{OyNlIh|ryP NV3TfXRXW0GQR1XS
SW1573 M2\Odmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGjBTnpKSzVyPUOuO|U{PDhizszN M4i5SXNCVkeHUh?=
769-P M{\iXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTNwOEK3OFMh|ryP M13NTnNCVkeHUh?=
KNS-62 NGPIRo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTNwOUKzN|gh|ryP NIrHTHNUSU6JRWK=
NCI-H747 NUHYbHBjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTRwMEW2N|gh|ryP MnjEV2FPT0WU
LN-405 NIOzU3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXO1R3JkUUN3ME20MlE2PzJ6IN88US=> NHrCSmVUSU6JRWK=
OVCAR-8 NYnqe|ZWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnLxTWM2OD12LkKyOVQ{KM7:TR?= MYTTRW5ITVJ?
DMS-114 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlnjTWM2OD12LkKzPFkyKM7:TR?= NUHoUXNKW0GQR1XS
NCI-H2126 M1XpOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{jseGlEPTB;ND6yOFU2QCEQvF2= NXTCbZdoW0GQR1XS
TCCSUP NYTQXHZPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2jldmlEPTB;ND6yOFc5QCEQvF2= NXOwSIpGW0GQR1XS
SK-N-FI NHK0Xm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1T6U2lEPTB;ND6yOVM{OiEQvF2= MYTTRW5ITVJ?
HCE-4 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mm[4TWM2OD12LkK3NVk4KM7:TR?= MmHXV2FPT0WU
DK-MG NHS2eY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTRwM{CzPUDPxE1? MkTyV2FPT0WU
RO82-W-1 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\t[mlEPTB;ND6zNlU5PCEQvF2= NF\JZlZUSU6JRWK=
A2780 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEP6c4xKSzVyPUSuN|Y3QDJizszN NUnuWplTW0GQR1XS
ETK-1 NVzwUlFCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{fZXGlEPTB;ND6zO|A2OiEQvF2= NXLxNlA2W0GQR1XS
FADU MkXpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXjxSVFFUUN3ME20MlM4PDZ5IN88US=> NX2xRWFyW0GQR1XS
CAL-12T NH3KUFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYrSZYxmUUN3ME20MlQyPDF|IN88US=> NGXk[pBUSU6JRWK=
647-V MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTRwNESwNlIh|ryP MoDqV2FPT0WU
TGBC1TKB MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF;5b4hKSzVyPUSuOFUyOTNizszN M3LrOnNCVkeHUh?=
LU-99A MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{WxdGlEPTB;ND60OlA3KM7:TR?= MonpV2FPT0WU
CAL-33 MojpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIj5V2RKSzVyPUSuOVI1PTZizszN NFPDbIJUSU6JRWK=
LU-134-A M2L4TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlHOTWM2OD12LkWyO|Q2KM7:TR?= M3;BR3NCVkeHUh?=
NCI-H1355 NYTI[ZF3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWjUZphKUUN3ME20MlU2OTR4IN88US=> NWTiVlB5W0GQR1XS
RPMI-7951 NEH2dXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml:4TWM2OD12LkW3NFAzKM7:TR?= NXrhSZFpW0GQR1XS
TE-1 NWfuUlhNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkXpTWM2OD12Lk[2NVQ{KM7:TR?= NGXFS5RUSU6JRWK=
OE33 NFfHb2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4P6WmlEPTB;ND63NFUyOSEQvF2= MmWyV2FPT0WU
CAL-51 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;XOGJMUUN3ME20MlcyODh{IN88US=> MUnTRW5ITVJ?
SW1783 M4PwN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTRwN{WzNFgh|ryP NHvvdGVUSU6JRWK=
BT-474 NE[yZ4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVPlNYhbUUN3ME20Mlc3Ozh2IN88US=> NYnGTIZTW0GQR1XS
KYSE-520 NFLPRoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{iwNWlEPTB;ND64O|M6OiEQvF2= MVnTRW5ITVJ?
8-MG-BA NUe4WVBYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTRwOEi1OVch|ryP MmfuV2FPT0WU
IA-LM NUPqbm56T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mmf0TWM2OD12Lkm5OFM2KM7:TR?= M2X6O3NCVkeHUh?=
SW954 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjVc417UUN3ME20Mlk6PDR|IN88US=> MoDxV2FPT0WU
RPMI-8226 NF2yPZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV6zVHZrUUN3ME21MlA2PDZzIN88US=> M3[5RXNCVkeHUh?=
MKN1 Ml7nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkPpTWM2OD13LkC3PVI4KM7:TR?= MWHTRW5ITVJ?
A375 NF7wfJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoLmTWM2OD13LkC5NlU3KM7:TR?= NVj3TZU1W0GQR1XS
8305C MkfvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTVwMEm4PFch|ryP NFm3fYFUSU6JRWK=
CAL-62 Mn7DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIHyR49KSzVyPUWuNVgzPTlizszN NUTOO|doW0GQR1XS
NB10 MlzyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH35[FJKSzVyPUWuNlI4PDRizszN NInjSWZUSU6JRWK=
OC-314 M17p[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTVwM{e0OFQh|ryP MXzTRW5ITVJ?
PSN1 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\uPGlEPTB;NT6zPFI5PiEQvF2= M1\D[HNCVkeHUh?=
GR-ST NITzcXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NInZeXRKSzVyPUWuN|g{OjJizszN NVixO|NYW0GQR1XS
P12-ICHIKAWA MnLBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml7oTWM2OD13LkSwNUDPxE1? MVzTRW5ITVJ?
NCI-H1092 Mnj2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX\s[IhzUUN3ME21MlQyOTR6IN88US=> M2TSbHNCVkeHUh?=
SCC-4 M4TkU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnzTTWM2OD13LkSxN|U2KM7:TR?= M1vWZnNCVkeHUh?=
TE-6 M{nY[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4DqUWlEPTB;NT60NVgyPiEQvF2= M1fHb3NCVkeHUh?=
DOHH-2 NYrVfJBDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVqxcYZxUUN3ME21MlQzOjR6IN88US=> NGGwcGtUSU6JRWK=
SW684 MmfTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIHaWo5KSzVyPUWuOlY{QDVizszN MnLDV2FPT0WU
CP50-MEL-B NUfX[mw4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUnYd|Q1UUN3ME21MlY5Pjh2IN88US=> M{nvZXNCVkeHUh?=
UM-UC-3 NHL4dmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXfnRYRFUUN3ME21MlczOjNzIN88US=> MmXDV2FPT0WU
LC-2-ad M4PhPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml;MTWM2OD13Lke4NlUyKM7:TR?= MUfTRW5ITVJ?
PC-3 NEKxWW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRTVwOUG2NVUh|ryP MmTRV2FPT0WU
CAN M13lZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTVwOUK4NkDPxE1? M2LoT3NCVkeHUh?=
ESS-1 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTVwOUe4Olkh|ryP NIXNb2ZUSU6JRWK=
ATN-1 NYnuZ3BlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1nZdWlEPTB;Nj6wOVU3QCEQvF2= M2j3S3NCVkeHUh?=
BxPC-3 NHXIRpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2q0N2lEPTB;Nj6wPFIyQSEQvF2= NVLvNIpHW0GQR1XS
KYSE-150 NEW5PHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV\JR|UxRTZwMUK0O|Yh|ryP NV3kdpY{W0GQR1XS
RPMI-8866 M3rMSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUXJR|UxRTZwMUmxOlMh|ryP NHLCVVJUSU6JRWK=
SW780 NEK1NZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;lZm51UUN3ME22MlIxPDJizszN NGLyUYxUSU6JRWK=
A388 MlPDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTZwMkOxNVUh|ryP MWXTRW5ITVJ?
NCI-H1437 MoPmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmPOTWM2OD14LkK0NFc{KM7:TR?= NILqV4hUSU6JRWK=
NCI-H1755 NXGxeFZ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnvOTWM2OD14LkO2OlEzKM7:TR?= MkfZV2FPT0WU
LS-123 NXXQVVBET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGm2[oRKSzVyPU[uOFA2OjFizszN M3LtTnNCVkeHUh?=
CaR-1 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTZwNE[zO|Mh|ryP MVjTRW5ITVJ?
RT-112 MlLxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTZwNkCzN|gh|ryP M2OzR3NCVkeHUh?=
CGT NHqxN4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zO[WlEPTB;Nj63N|Y5OSEQvF2= MlTJV2FPT0WU
SW626 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\2TWM2OD14LkezPVQ3KM7:TR?= M3;ndXNCVkeHUh?=
AsPC-1 NULh[4NUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWHGXnVxUUN3ME22Mlc1PTB5IN88US=> NH\KTHBUSU6JRWK=
SBC-5 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3\XVGlEPTB;Nj65O|I6PyEQvF2= NFmxPIlUSU6JRWK=
SF539 NF3ze25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTZwOUmzN|Mh|ryP NVvzR481W0GQR1XS
TI-73 NHLHNoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTdwME[yPFUh|ryP NWrBPXNrW0GQR1XS
MHH-ES-1 M{fBUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmf4TWM2OD15LkC3O|YzKM7:TR?= MmDJV2FPT0WU
KYSE-510 NHfoVY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmDXTWM2OD15LkC4OFMzKM7:TR?= MnyyV2FPT0WU
EW-1 Mom3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIP3dphKSzVyPUeuN|Y6QTZizszN NGTxPIZUSU6JRWK=
SK-OV-3 NHrv[oVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTdwM{m0N|Ih|ryP MkTPV2FPT0WU
MC-IXC NIqxc3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlXzTWM2OD15LkSxPVczKM7:TR?= M3zzdnNCVkeHUh?=
HSC-2 Mkn6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmGzTWM2OD15LkSyO|A2KM7:TR?= M33RXXNCVkeHUh?=
NCI-H2342 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1S5VWlEPTB;Nz61NVQ6KM7:TR?= NVXMZVlsW0GQR1XS
NCI-H1792 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX:0TIdCUUN3ME23MlUyPzFzIN88US=> NEjD[oJUSU6JRWK=
HT-1376 MnrYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFzqdJBKSzVyPUeuPFc4PzhizszN MVfTRW5ITVJ?
EW-13 Moe5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\EZ2lEPTB;Nz64PVk4PyEQvF2= NH7yUlRUSU6JRWK=
no-11 NFvDdndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTdwOUCxO|Qh|ryP MUHTRW5ITVJ?
Daoy NGLqdoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3j[JpLUUN3ME23Mlk1OzJzIN88US=> NHS5To5USU6JRWK=
COLO-800 NX7JW5FTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRThwMESxOlIh|ryP MVTTRW5ITVJ?
GB-1 M{jwRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRThwME[1OlUh|ryP MY\TRW5ITVJ?
SJRH30 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvnTWM2OD16LkG1PFc5KM7:TR?= NFjEfXpUSU6JRWK=
NCI-H2291 NELTSWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGS0fFRKSzVyPUiuNlkyQDdizszN MknKV2FPT0WU
J82 NWTtV3NqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;4WWFKSzVyPUiuNlk1QTFizszN MkDjV2FPT0WU
NCI-H596 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIHmSplKSzVyPUiuN|E1PTNizszN NFH1N|hUSU6JRWK=
RERF-LC-MS M1mxOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGfxUFNKSzVyPUiuN|Q5PTZizszN MVvTRW5ITVJ?
RH-18 NHfuR|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\WdWlEPTB;OD6zOVA1PiEQvF2= MVHTRW5ITVJ?
SW48 NXTtSYxST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRThwNUm0OVMh|ryP MmXZV2FPT0WU
RD NUjZXmxqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVj3cVNbUUN3ME24MlU6OzlzIN88US=> M2TabnNCVkeHUh?=
MS-1 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRThwNkGzPFch|ryP NGrJbWZUSU6JRWK=
ES6 NFnnOZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVLLdVc2UUN3ME24Mlc{OTF7IN88US=> NEjEZW9USU6JRWK=
TE-12 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkXrTWM2OD16Lke3OVA2KM7:TR?= NUjFfGlIW0GQR1XS
DBTRG-05MG M3rLPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\mXmlEPTB;OD65NVIyPyEQvF2= NX\kPFl3W0GQR1XS
KINGS-1 M3vHXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1XibWlEPTB;OD65Nlk{QCEQvF2= MkTTV2FPT0WU
HLE Ml:1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NILxRpdKSzVyPUiuPVM4QDVizszN NX7OUZhFW0GQR1XS
MHH-NB-11 M2XOUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYXnWVFbUUN3ME25MlAyQDN7IN88US=> NFfhZ2NUSU6JRWK=
U-87-MG NFzEblhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVK2OIU6UUN3ME25MlI1OzJzIN88US=> MoHtV2FPT0WU
MN-60 MkTKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NET1VnlKSzVyPUmuNlQ2PDJizszN M1rCenNCVkeHUh?=
SAS NWHMVZcxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH\rZ4xKSzVyPUmuNlU2QDFizszN Mk\pV2FPT0WU
NCI-H446 M3fGSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUK5TodxUUN3ME25MlM3OSEQvF2= MlrUV2FPT0WU
C-33-A MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTlwNEO5PFgh|ryP NFTjOFBUSU6JRWK=
RXF393 NVuycnN{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUPqVms6UUN3ME25MlQ4ODB{IN88US=> NELQWpZUSU6JRWK=
CGTH-W-1 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MleyTWM2OD17LkS5N|g1KM7:TR?= MYPTRW5ITVJ?
RCM-1 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1PJR2lEPTB;OT62N|gxOSEQvF2= MVfTRW5ITVJ?
SN12C M1POTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3j1V2lEPTB;OT62OVM{QCEQvF2= NGCwXGNUSU6JRWK=
KLE MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTlwN{CwNFkh|ryP MYPTRW5ITVJ?
EFO-21 MofGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH3EemRKSzVyPUmuO|c{QDJizszN M3yzcHNCVkeHUh?=
KYSE-70 M2fVXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWnYdldbUUN3ME25Mlg5ODFzIN88US=> NWHYOpR7W0GQR1XS
D-247MG M{K5[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLzb|NKSzVyPUGwMlA2PjhizszN NVP4To94W0GQR1XS
MPP-89 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NILtN2JKSzVyPUGwMlA6PDZizszN MXzTRW5ITVJ?
RVH-421 NVvYe|FJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MofVTWM2OD1zMD6xOVA2KM7:TR?= NFTuPVlUSU6JRWK=
NCI-H460 NInOemlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX20N5ZZUUN3ME2xNE4zQDB4IN88US=> MoHlV2FPT0WU
NOMO-1 M2rrO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmPJTWM2OD1zMD6zOVMzKM7:TR?= M4jsT3NCVkeHUh?=
DEL Mm\OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnmyTWM2OD1zMD6zO|k1KM7:TR?= M4HJPXNCVkeHUh?=
HT55 NH\NdmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTFyLk[yNFUh|ryP NVG2XZBlW0GQR1XS
MC116 NYXZZ3VlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;KUmlEPTB;MUCuOlY2PSEQvF2= NEfZ[FVUSU6JRWK=
BB30-HNC NXjZXJZPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnrDTWM2OD1zMD62Olkh|ryP M3GwbXNCVkeHUh?=
DJM-1 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2jUO2lEPTB;MUCuOlk1QSEQvF2= MVnTRW5ITVJ?
ZR-75-30 NGG2Wm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2LhZWlEPTB;MUCuPVQ1OSEQvF2= MX;TRW5ITVJ?
U-118-MG NG\SeVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYXSb5lWUUN3ME2xNE46QDl4IN88US=> MUnTRW5ITVJ?
MSTO-211H MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTFzLkC3NVYh|ryP NUTHXW11W0GQR1XS
SW837 MlzZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIHsOmdKSzVyPUGxMlA6PDlizszN NILnPYFUSU6JRWK=
HuCCT1 NWnRTGxxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFK5Z41KSzVyPUGxMlEzQDFizszN Mk\DV2FPT0WU
RCC10RGB M2i3b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmDmTWM2OD1zMT6xN|Uh|ryP NV[4XJBsW0GQR1XS
NMC-G1 NVHzVmwxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4H2fWlEPTB;MUGuNVQ6OyEQvF2= MmrnV2FPT0WU
NCI-H650 M4iyb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFjkbGpKSzVyPUGxMlM4QTRizszN NXjwUVJnW0GQR1XS
HEC-1 MnnKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M37WTmlEPTB;MUGuOFMzQCEQvF2= M4DLS3NCVkeHUh?=
DU-4475 NVT0c49GT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTFzLkezPVMh|ryP MYjTRW5ITVJ?
DSH1 MoD0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3vHemlEPTB;MUGuO|YxPiEQvF2= MUTTRW5ITVJ?
HCC1569 NGO2OVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEm4NG5KSzVyPUGxMlc3PzhizszN NELzbnFUSU6JRWK=
HCC1187 M{jVSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlzyTWM2OD1zMT64OVg5KM7:TR?= MWTTRW5ITVJ?
EW-11 M1[zOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXzrUXY4UUN3ME2xNU46PDd2IN88US=> MmPjV2FPT0WU
LB2518-MEL NH\odnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU[4NYt1UUN3ME2xNk4xPTlizszN NUjOSJJIW0GQR1XS
KALS-1 NFHWSHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\CS2U{UUN3ME2xNk45PTV|IN88US=> NF6zUIlUSU6JRWK=
8505C MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYTxSllLUUN3ME2xNk45QDVizszN M3vtd3NCVkeHUh?=
SK-N-DZ M4[5b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYrQbJd7UUN3ME2xN{4xPDV|IN88US=> NHfNRW9USU6JRWK=
CHP-134 NGDqW|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFvTPZdKSzVyPUGzMlEyPThizszN MV;TRW5ITVJ?
HCE-T M2rlNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVjxUIRJUUN3ME2xN{4zOzZ2IN88US=> M1q0fHNCVkeHUh?=
LB-831-BLC M3ftTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkDCTWM2OD1zMz62NlQ3KM7:TR?= NXjTWWZ7W0GQR1XS
OVCAR-4 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlK1TWM2OD1zMz62OVI1KM7:TR?= NGnmTVVUSU6JRWK=
SW756 M3:yNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTF|LkeyOFYh|ryP M1;aV3NCVkeHUh?=
OCUB-M M2PZUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTF|LkixOVYh|ryP MV3TRW5ITVJ?
SW982 NFXrcpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3PDOWlEPTB;MUOuPFI4PiEQvF2= M4PwOHNCVkeHUh?=
DB NXj6Zo1IT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{C5U2lEPTB;MUOuPFM5PCEQvF2= NGi3d5pUSU6JRWK=
H-EMC-SS MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWnGWXhFUUN3ME2xN{46OTN7IN88US=> MXjTRW5ITVJ?
VMRC-RCZ NHXvem5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXH2bIlHUUN3ME2xOE4xODF3IN88US=> M4radnNCVkeHUh?=
CAKI-1 Mo\ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mor0TWM2OD1zND6wNVMzKM7:TR?= NXXvTXdWW0GQR1XS
GI-1 NUnkTY06T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{\VRmlEPTB;MUSuNFY2QCEQvF2= NF7MU3RUSU6JRWK=
Ca9-22 M3LSTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIXVTo9KSzVyPUG0MlYxPTRizszN NULQepprW0GQR1XS
TE-5 NIjyeYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUH1[2pGUUN3ME2xOE44OjB6IN88US=> NXHUSZhwW0GQR1XS
EFO-27 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTF2Lke2NlIh|ryP Mn3FV2FPT0WU
CAL-72 MlTLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFLvdIxKSzVyPUG0Mlc4QDNizszN M1jtPHNCVkeHUh?=
GP5d M1:zc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTF3LkC0O|Qh|ryP Mn;rV2FPT0WU
CAS-1 NVzUOpRCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjJR|UxRTF3LkC2OkDPxE1? MljVV2FPT0WU
A2058 M1\QTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3PXemlEPTB;MUWuOVY{QCEQvF2= M3y2[nNCVkeHUh?=
PANC-08-13 MnjRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVfNeoNXUUN3ME2xOU43QDV7IN88US=> M3rsR3NCVkeHUh?=
Detroit562 Mle2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnXCTWM2OD1zNT65NVM6KM7:TR?= M2ezNnNCVkeHUh?=
PANC-10-05 M2\1WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTF4LkC4NlEh|ryP M4PVTXNCVkeHUh?=
KOSC-2 NHXXPHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPYS3FKSzVyPUG2MlEyOjVizszN M3\XfXNCVkeHUh?=
GT3TKB Mn3xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\TVmlEPTB;MU[uNVk5OSEQvF2= MkS3V2FPT0WU
KM-H2 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVLZNIRMUUN3ME2xOk4{PjR4IN88US=> M1PVc3NCVkeHUh?=
LB771-HNC M{fCW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEi0NVNKSzVyPUG2MlQ1OjJizszN NEXCVlFUSU6JRWK=
SF268 MmfRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTF4LkS1NkDPxE1? MnPhV2FPT0WU
OE19 M3jk[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGHpWGJKSzVyPUG2MlUzPCEQvF2= NInvV2RUSU6JRWK=
MLMA M{XKRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTF4LkW1O|Eh|ryP NWDydFhtW0GQR1XS
MDA-MB-231 M3jzemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXXJR|UxRTF4LkexN|Yh|ryP MVTTRW5ITVJ?
TGW M4fZVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{X1SmlEPTB;MU[uPFExOiEQvF2= NWrxdJFKW0GQR1XS
MDA-MB-453 NFzyNIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTF5LkCwNFMh|ryP MnXrV2FPT0WU
SNU-C2B NVqzNJRRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4XBR2lEPTB;MUeuNFI{PyEQvF2= MWLTRW5ITVJ?
A427 NEKySoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlvPTWM2OD1zNz6yN|M1KM7:TR?= MX\TRW5ITVJ?
SK-MEL-2 NV;B[m1uT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnX5TWM2OD1zNz6zNlE{KM7:TR?= M{DsPHNCVkeHUh?=
KURAMOCHI M1;xOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVn0eXJzUUN3ME2xO{4{QDl5IN88US=> NHe2eJpUSU6JRWK=
IST-MEL1 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTF5LkmxPFIh|ryP MkT4V2FPT0WU
NCI-H1793 Mo\yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHjyWm1KSzVyPUG4MlE2QDFizszN NYnaT4ExW0GQR1XS
HCC1395 NVXKc4ptT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2LtNGlEPTB;MUiuOVYyOSEQvF2= NIO2WJdUSU6JRWK=
NUGC-3 NWTsZppmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE\ybo5KSzVyPUG4MlY2QDRizszN MVnTRW5ITVJ?
BB65-RCC MlLPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MojUTWM2OD1zOD62Olkh|ryP NV;kZ21kW0GQR1XS
RMG-I MmW1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1LkWmlEPTB;MUiuO|M5OiEQvF2= MXPTRW5ITVJ?
LS-513 NHPkZVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTF6LkmyNlgh|ryP MWXTRW5ITVJ?
MFM-223 NV2xO5lrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{\kc2lEPTB;MUmuNFcyPiEQvF2= NFLSTmpUSU6JRWK=
NCI-H727 M1O0UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTF7LkOyPVUh|ryP MVzTRW5ITVJ?
KP-4 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYfJUXBZUUN3ME2xPU45PTNzIN88US=> NW\kUmw1W0GQR1XS
NB13 MmPVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTF7Lki4N|kh|ryP MULTRW5ITVJ?
UACC-893 MoTRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoHwTWM2OD1zOT65O|U4KM7:TR?= M2rUenNCVkeHUh?=
HT-1197 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn2zTWM2OD1{MD6yPVU5KM7:TR?= MlTXV2FPT0WU
NCI-H2029 M4G0SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2\3XGlEPTB;MkCuN|I3PiEQvF2= MWHTRW5ITVJ?
GI-ME-N Ml25S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MorBTWM2OD1{MD6zN|c{KM7:TR?= MlrlV2FPT0WU
OVCAR-3 M2POOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGeySnlKSzVyPUKwMlU5OjJizszN MV3TRW5ITVJ?
HD-MY-Z MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3uzcWlEPTB;MkGuN|Y6PiEQvF2= NFPLNm1USU6JRWK=
NTERA-S-cl-D1 NHyxdoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3jITWlEPTB;MkGuOlczOiEQvF2= NFSwN5hUSU6JRWK=
SCH MnO2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmXpTWM2OD1{Mj60PVYh|ryP NGC1fZZUSU6JRWK=
KARPAS-299 NYS1SIhxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGT6RY9KSzVyPUKzMlM5QDdizszN M2X0S3NCVkeHUh?=
NCI-H1650 MnX3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGSyfVlKSzVyPUKzMlkzPDFizszN NVqydFQ{W0GQR1XS
ACHN MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTJ2LkS2OVYh|ryP NXjzXmpwW0GQR1XS
M059J Mn60S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NULyWJZrUUN3ME2yOE42PjN2IN88US=> M2SzNXNCVkeHUh?=
AM-38 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPEZ|BMUUN3ME2yOU41QDFizszN NH\BW2NUSU6JRWK=
KG-1 MlLES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MknuTWM2OD1{NT61OFk1KM7:TR?= MVLTRW5ITVJ?
COLO-824 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkjwTWM2OD1{NT61OVk6KM7:TR?= NYDPSFNoW0GQR1XS
NCI-H1155 NWDGN21JT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlToTWM2OD1{NT61PFQ4KM7:TR?= NVntNGdOW0GQR1XS
NCI-H441 NF73OZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIHvUFRKSzVyPUK1Mlc1PjVizszN NF31cnhUSU6JRWK=
J-RT3-T3-5 Ml2xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn;BTWM2OD1{Nj6zNFI4KM7:TR?= NYf6THliW0GQR1XS
JEG-3 MoHSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3vMOWlEPTB;Mk[uOlgxPSEQvF2= MXrTRW5ITVJ?
RKO M{LVO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGq3[llKSzVyPUK2Mlc3OzJizszN MlXxV2FPT0WU
CAL-85-1 M1rlNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{LRfWlEPTB;MkeuNlEyQCEQvF2= NWHSPIJvW0GQR1XS
CAL-120 NWnXem5OT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTJ5Lk[5NVQh|ryP M3nXc3NCVkeHUh?=
NCI-H2452 NXHpSpd3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTJ5Lke3NVYh|ryP MofXV2FPT0WU
NCI-H1395 Mme2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY\jZpFKUUN3ME2yO{44QDN|IN88US=> M32wN3NCVkeHUh?=
KYSE-450 NEjkXJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFTZVYlKSzVyPUK3Mlk5PjJizszN NIrP[G1USU6JRWK=
S-117 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTJ7LkO4OVch|ryP M1zjTXNCVkeHUh?=
SW13 Mn\YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEX1fGVKSzVyPUK5Mlg2OTlizszN MV;TRW5ITVJ?
ES3 NHfkO5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkT2TWM2OD1|MD6zO|M{KM7:TR?= M1O0UXNCVkeHUh?=
HCT-116 MmfpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmXpTWM2OD1|MD61OVU1KM7:TR?= NWf0N49YW0GQR1XS
NCI-H1693 NVHNPYNuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYTjV4cxUUN3ME2zNE42QTR{IN88US=> NVHE[|I5W0GQR1XS
VM-CUB-1 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MojSTWM2OD1|MD62OFE{KM7:TR?= NH\mOVJUSU6JRWK=
NCI-H2170 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4nl[mlEPTB;M{GuOVc5PCEQvF2= M3jL[HNCVkeHUh?=
ALL-PO MmXNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4TOZ2lEPTB;M{GuPFQzQCEQvF2= MXXTRW5ITVJ?
NCI-H661 NUC5WnJbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTN{LkC2NlMh|ryP NHm0Zm9USU6JRWK=
NCI-H2347 M3rTTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVTJR|UxRTN{LkS4N|ch|ryP MXfTRW5ITVJ?
FTC-133 NVTHVGdMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUPJR|UxRTN{LkewOkDPxE1? M4nDbXNCVkeHUh?=
COLO-829 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWm0T2tqUUN3ME2zN{4{PDZ5IN88US=> M{GyW3NCVkeHUh?=
GOTO NHHMfHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXG4XlJWUUN3ME2zN{42OjV6IN88US=> NEf6RWNUSU6JRWK=
YAPC MmDBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF\NRphKSzVyPUOzMlgyPTlizszN MoTiV2FPT0WU
LCLC-103H NEPidI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFXVXnFKSzVyPUO0MlE3OjRizszN NH7TNJhUSU6JRWK=
SiHa NFXtcZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkCzTWM2OD1|ND6zPFE4KM7:TR?= MkOwV2FPT0WU
LK-2 NFvLd|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUXCeJBrUUN3ME2zOE42PzB6IN88US=> NXTxN49qW0GQR1XS
KP-N-YS NVvTPZBIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVfU[lRnUUN3ME2zOE44OjB{IN88US=> M3PhdnNCVkeHUh?=
NCI-SNU-1 NFLPcFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFfG[3RKSzVyPUO1MlE4QSEQvF2= MU\TRW5ITVJ?
KNS-81-FD NVPZZWRqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlrxTWM2OD1|NT62OlMh|ryP NWrsXFJpW0GQR1XS
SCC-9 MoL5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MofuTWM2OD1|Nj63NVQ3KM7:TR?= NWnzSYdJW0GQR1XS
SH-4 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlP1TWM2OD1|Nj63N{DPxE1? M4L6O3NCVkeHUh?=
HCC-1954 M1Ptc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXSxcVRWUUN3ME2zO{4zPzJ7IN88US=> MkfDV2FPT0WU
BALL-1 M{LISmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3vHdGlEPTB;M{euOVMyPiEQvF2= MXzTRW5ITVJ?
BE-13 MmPQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M13lWmlEPTB;M{euO|AyQCEQvF2= MYTTRW5ITVJ?
COLO-678 M{HZO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUmwdHFYUUN3ME2zO{46PDN5IN88US=> MmTlV2FPT0WU
SK-MEL-3 M4XYZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mni0TWM2OD1|OD6yN|k4KM7:TR?= MXrTRW5ITVJ?
OAW-28 MnL4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHjteW1KSzVyPUO4MlY{QSEQvF2= M1LhXXNCVkeHUh?=
CAMA-1 MkPoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXzXXXU5UUN3ME2zPE46PjlzIN88US=> NXm3bohDW0GQR1XS
C2BBe1 NWrhVW5ZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTN7LkixPEDPxE1? MnXCV2FPT0WU
A3-KAW MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTRyLkO2OlEh|ryP NUDRNmtNW0GQR1XS
SK-MEL-24 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTRyLkW5N|Eh|ryP M4rOVnNCVkeHUh?=
KYSE-140 M160[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlrFTWM2OD12MD63NVY2KM7:TR?= M{XxfXNCVkeHUh?=
MOLT-16 NHHkXXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH7t[HpKSzVyPUSxMlE2OzZizszN NYnWPFU1W0GQR1XS
CFPAC-1 NUT1U5FpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{PGSmlEPTB;NEKuOVIyOSEQvF2= MXjTRW5ITVJ?
NB14 NHO2e|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUXFdW5ZUUN3ME20Nk44ODJ5IN88US=> Mmr5V2FPT0WU
COLO-792 MkPRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUewSo9YUUN3ME20Nk45QTZzIN88US=> MkfQV2FPT0WU
RH-1 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4HHR2lEPTB;NEOuOFg{PiEQvF2= MXrTRW5ITVJ?
NCI-H522 NXSzXlFOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFricHdKSzVyPUS0MlM2PjhizszN MUfTRW5ITVJ?
Ca-Ski MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH7qOJpKSzVyPUS0MlgyOTRizszN Ml3iV2FPT0WU
KGN MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGXkUZpKSzVyPUS4MlMxPjNizszN NF7Oc5lUSU6JRWK=
UACC-62 Mn\rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTR6LkSwO|Ih|ryP NVrCb5FvW0GQR1XS
NCI-H358 NF7adIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;QbopKSzVyPUS5MlMxOThizszN MVPTRW5ITVJ?
LS-411N MnXJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NELMOpNKSzVyPUS5MlMyOThizszN NYTa[4pDW0GQR1XS
IST-MES1 MnftS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH7GZYpKSzVyPUS5MlU3OjVizszN MXvTRW5ITVJ?

... Click to View More Cell Line Experimental Data

In vivo Administration of GDC-0941 at 75 mg/kg/day displays significant inhibitory effect against established human U87MG glioblastoma xenografts in female NCr athymic mice, with tumor growth inhibition of 83%. [1] Oral administration of GDC-0941 at 150 mg/kg/day inhibits the growth of HER2-amplified, trastuzumab-resistant MDA-MB-361.1 xenografts in mice, and significantly delays the tumor progression, in association with potent induced apoptosis in tumors. [2] GDC-0941 (75 mg/kg/day) treatment for 2 weeks induces ~40% reduction in tumor volume of spontaneous B-cell follicular lymphomas developed in PTEN+/-LKB1+/hypo mice, accompanied by ablation of phosphorylation of Akt, S6K and SGK (serum and glucocorticoid protein kinase) protein kinases. [4]

Protocol

Kinase Assay:[1]
+ Expand

Scintillation proximity assay:

Recombinant human PI3Kα, PI3Kβ, and PI3Kδ are coexpressed in a Sf9 baculovirus system with the p85α regulatory subunit and purified as GST-fusion proteins using affinity chromatography on glutathione-sepharose. Recombinant human PI3Kγ is expressed as monomeric GST-fusions and purified similarly. GDC-0941 is dissolved in DMSO and added to 20 mM Tris-HCl (pH 7.5) containing 200 μg yttrium silicate (Ysi) polylysine SPA beads, 4 mM MgCl2, 1 mM dithiothreitol (DTT), 1 μM ATP, 0.125 μCi [γ-33P]-ATP, and 4% (v/v) DMSO in a total volume of 50 μL. The recombinant GST-fusion of PI3Kα (5 ng), PI3Kβ (5 ng), PI3Kδ (5 ng), or PI3Kγ (5 ng) is added to the assay mixture to initiate the kinase reaction. After incubation for 1 hour at room temperature, the kinase reaction is terminated with 150 μL PBS. The mixture is then centrifuged for 2 minutes at 2000 rpm and read using a Wallac Microbeta counter. The reported IC50 values are calculated using a sigmoidal, dose-response curve fit in MDL Assay Explorer.
Cell Research:[2]
+ Expand
  • Cell lines: SKBR-3, BT474-M1, AU-565, HCC-1419, ZR75-30, KPL-4, JIMT-1, BT474-EEI, HCC-1954, MCF-7, CALU-3, SKOV-3, and MKN-7 cells
  • Concentrations: Dissolved in DMSO, final concentrations ~10 μM
  • Incubation Time: 48 and 72 hours
  • Method: Cells are exposed to various concentrations of GDC-0941 for 48, and 72 hours. Proliferation/viability of cells is detected by using the CellTiter-Glo Luminescent Cell Viability Assay. The pAkt (Ser473), cleaved caspase-3, and cleaved PARP are analyzed by western blot. The Caspase-Glo 3/7 assay and the Cell Death Detection ELISAplus assay are used to detect caspase 3/7 activity, and apoptosis, respectively.
    (Only for Reference)
Animal Research:[2]
+ Expand
  • Animal Models: NCR nude mice implanted with MDA-MB-361.1 cells, and SCID, C.B-17/IcrHsd-Prkdcscid mice implanted subcutaneously with BT474-M1 cells
  • Formulation: Dissolved in 10% DMSO, 5% Tween 20, 85% water
  • Dosages: ~150 mg/kg/day
  • Administration: Oral gavage
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 44 mg/mL (85.66 mM)
Water <1 mg/mL
Ethanol <1 mg/mL
In vivo 2% DMSO+30% PEG 300+5% Tween 80+ddH2O 5mg/mL

* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 513.64
Formula

C23H27N7O3S2

CAS No. 957054-30-7
Storage powder
in solvent
Synonyms RG7321

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00999128 Completed Healthy Volunteers Genentech, Inc. October 26, 2009 Phase 1
NCT02092831 Completed Healthy Volunteer Genentech, Inc. April 2014 Phase 1
NCT01740336 Active, not recruiting Breast Cancer Genentech, Inc. February 2013 Phase 2
NCT01493843 Completed Non-Squamous Non-Small Cell Lung Cancer Genentech, Inc. January 2012 Phase 2
NCT01474668 Completed Healthy Volunteer Genentech, Inc. October 2011 Phase 1
NCT01437566 Completed Breast Cancer Genentech, Inc. October 2011 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

PI3K Signaling Pathway Map

PI3K Inhibitors with Unique Features

Related PI3K Products

Tags: buy Pictilisib (GDC-0941) | Pictilisib (GDC-0941) supplier | purchase Pictilisib (GDC-0941) | Pictilisib (GDC-0941) cost | Pictilisib (GDC-0941) manufacturer | order Pictilisib (GDC-0941) | Pictilisib (GDC-0941) distributor
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID