Pictilisib (GDC-0941)

Catalog No.S1065 Synonyms: RG7321

Pictilisib (GDC-0941) Chemical Structure

Molecular Weight(MW): 513.64

Pictilisib (GDC-0941) is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM in cell-free assays, with modest selectivity against p110β (11-fold) and p110γ (25-fold). Phase 2.

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Cited by 59 Publications

9 Customer Reviews

  • Clonogenic assays of TNBC cell lines grown continuously in increasing concentrations of palbociclib, divided by gene expression subtypes: LAR, luminal androgen receptor; MSL, mesenchymal stem-like; MES, mesenchymal and basal-like. All cell lines are RB1 wild-type except RB1 mutant BT549.

    Clin Cancer Res, 2017, 23(18):5561-5572. Pictilisib (GDC-0941) purchased from Selleck.

    Dual PI3K/BRAF inhibition upregulates BIM and enhances apoptosis in PTEN cells. A, left, Western blot of 1205Lu cells treated with PLX4720 (3 μmol/L, 48 hours), the PI3K inhibitor GDC-0941 (3 μmol/L, 48 hours), or both drugs in combination (PtG); right, immunofluorescence staining of BIM (green) and DAPI (blue) in PTEN cells following PLX4720 treatment (3 μmol/L, 48 hours), the PI3K inhibitor LY294002 (10 μmol/L, 48 hours), or both drugs in combination (PLXtLY). B, left, immunofluorescence staining of PTEN 1205Lu following combined inhibition (3 μmol/L PLX4720 t 10 μmol/L LY294002, 48hours) increases nuclear localization of FOXO3a (green). DAPI is shown in blue. Magnification 40. Right, combined inhibition (3 μmol/L PLX4720 t 10 μmol/L LY294002, 48 hours) increases PTEN WM793 BIM mRNA levels to those observed with single BRAF inhibition (3 μmol/L PLX4720, 48 hours) in the PTENt WM35. C, PTEN cells were treated with PLX4720 (3 μmol/L, 48 hours), GDC-0941 (3 μmol/L, 48hours), or a combination of the 2 drugs (3Pt3G) before Annexin-V staining was analyzed by flow cytometry (*, P < 0.05 between the drug combination and each inhibitor alone). D, combined BRAF/PI3K inhibitor treatment blocks the escape of 1205Lu cells (PTEN) from therapy. Spheroids of 1205Lu cells were treated with either PLX4720 alone (3 and 10 μmol/L: data shows 3 mmol/L), LY294002 (10 μmol/L) alone or a combination of the 2 drugs for 72 hours. In other studies, spheroids were treated with drugs for 72 hours and then allowed to recover for 120 hours. Micrograph shows viability staining (green= live cells, red= dead cells). Magnification 10×.

    Cancer Res 2011 71, 2750-2760. Pictilisib (GDC-0941) purchased from Selleck.

  • Combination of rapamycin and PI-103 leads to the suppression of AKT phosphorylation (phospho-specific western blot). Mel-Juso and 518A2 cells were treated with GDC-0941 from 0.05–1 μmol/L alone and in combination with rapamycin (50 nmol/L) for 24 hours. Control treatment was with DMSO.

     

     

    J Inves Der 2010 131, 495-503. Pictilisib (GDC-0941) purchased from Selleck.

    Growth inhibition induced by the FGFR inhibitor BGJ398 and the PI3K inhibitors alone or in combination. AN3CA (A-C), JHUEM2 (D-F) and MFE296 (G-I) cells were treated with the indicated doses of BGJ398, GDC-0941 a n d BYL719 alone or in combination for 96 hours and an Sulforhodamine B (SRB) assay was subsequently performed. Data are presented as a percentage of the control, in which cells were treated with 0.1% (v/v) DMSO. Points represent the mean of three independent experiments (each performed in triplicate). Error bars represent the standard error of the mean (SEM) and lines were fitted using non-linear regression analysis. Interaction of BGJ398 and GDC-0941(redcircles) or BYL719(blacksquares) in AN3CA(C), JHUEM2(F) and MFE296(I). Median effect analysis was used to evaluate the interaction between the inhibitor combinations. Horizontal dotted lines indicate the boundaries for each interaction classification.

    Mol Cancer Ther, 2017, 16(4):637-648. Pictilisib (GDC-0941) purchased from Selleck.

  • TGF-β induces mTORC2 activation. ( A ) NMuMG cells were treated with TGF-β for the indicated times before lysis and immunoblotting. (B ) NMuMG cells were treated or not with TGF-β for the indicated times, in the presence or absence of SB431542 or LY294002. Cell lysates were subjected to anti-Rictor immunoprecipitation, and the immunoprecipitates were subjected to in vitro kinase assays using kinase-inactive Akt1 as a substrate, before immunoblotting of the kinase reactions, immunoprecipitates and cell lysates. The left panels are from the same gel, without differential exposure. ( C ) NMuMG cells were treated or not with TGF-β or insulin for the indicated times, in the presence or absence of SB431542 or GDC-0941. The kinase activity of mTORC2 was then assessed as in B. The top panels are from the same gel, without differential exposure. (D) NMuMG cells were treated or not with TGF-β for the indicated times, in the presence or absence of SB431542 or LY294002. Cell lysates were subjected to immunoprecipitation using Rictor antibody, and/or immunoblotted.

    J Cell Sci 2012 125(Pt 5), 1259-73. Pictilisib (GDC-0941) purchased from Selleck.

    Effects of LY294002 and GDC-0941 on the high-glucose-induced plasma membrane translocation of DGK δ1. (A, C) HEK293 cells were transfected with pAcGFP-DGKδ1 or pAcGFP-C1 vector. After being glucose-starved for 2.5 h and the subsequent pretreatment with (A) 10 μM LY294002 (Sigma-Aldrich) or (C) 1 μM GDC-0941 (Selleck Chemicals) for 30 min, the cells were incubated with or without high glucose (25 mM) for 5 min. The cells were fixed with 3.7% formaldehyde and observed using confocal laser-scanning microscopy. Scale bar = 10 μm. (B, D) After treatment with (B) LY294002 or (D) GDC-0941, the percentages of cells exhibiting the translocation of AcGFP-tagged DGK δ 1 to the plasma membrane were scored. More than 20 cells ex-pressing AcGFP-tagged DGK δ1 were counted in each experiment. The results are the means ± S.D. of three independent experiments. The statistical significance was deter-mined using Student's t -test (** P < 0.01, *** P < 0.005)

    Biochim Biophys Acta 2012 1823, 2210-6. Pictilisib (GDC-0941) purchased from Selleck.

  • After starved in serum-free medium for 24h, Breast cancer cells incubated with the indicated concentrations of GDC-0941  for 3h,followed by 15-minute  stimulation of 100ng/ml EGF.

     

     

     

    Dr. Zhang of Tianjin Medical University. Pictilisib (GDC-0941) purchased from Selleck.

    We treated all of drugs in T47D which has a PI3KCA H1044R mutation with the concentration shown below for 1 hour and performed western blot analysis using antibodies to phospho-AKT(SERINE 472), and total AKT.

     

     

    Saraswati Sukumar of Johns Hopkins University School of Medicine. Pictilisib (GDC-0941) purchased from Selleck.

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    PI3K pathway signaling in GDC-0941 and MK-2206 treated MCF-7 derivatives with PIK3CA or  AKT1 mutations. Cells were grown in medium containing 5% FBS and treated with vehicle or increasing concentrations of GDC-0941 (0 nM, 50 nM, 100 nM, and 400 nM) or MK-2206 (0 nM, 100 nM, 250 nM, 1000 nM). After 24 hours of drug treatment, lysates were prepared and equal amounts of protein were load ed onto SDS-PAGE gels and blotted with the indicated antibodies.

    Pictilisib (GDC-0941) purchased from Selleck.

Purity & Quality Control

Choose Selective PI3K Inhibitors

Biological Activity

Description Pictilisib (GDC-0941) is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM in cell-free assays, with modest selectivity against p110β (11-fold) and p110γ (25-fold). Phase 2.
Targets
p110α [1]
(Cell-free assay)
p110δ [1]
(Cell-free assay)
p110β [1]
(Cell-free assay)
p110γ [1]
(Cell-free assay)
mTOR [1]
(Cell-free assay)
3 nM 3 nM 33 nM 75 nM 0.58 μM(Ki app)
In vitro

GDC-0941 is equipotent against PI3Kα and PI3Kδ as well as PI3Kα mutants E545-K and H1047-R, displaying modest levels of selectivity against PI3Kβ (10-fold) and PI3Kγ (25-fold), and greater levels of selectivity against members of PI3K class II, III, and IV, including C2β, Vps34, DNA-PK, and mTOR. GDC-0941 potently inhibits the phosphorylation of Akt in U87MG, PC3, and MDA-MB-361 cells with IC50 of 46 nM, 37 nM, and 28 nM, respectively. GDC-0941 inhibits the proliferation of U87MG, A2780, PC3, and MDA-MB-361 cells with IC50 of 0.95 μM, 0.14 μM, 0.28 μM, and 0.72 μM, respectively. [1] GDC-0941 treatment potently inhibits the proliferation of both trastuzumab-sensitive and -insensitive HER2-amplified cells with IC50 of 149-944 nM. GDC-0941 inhibits proliferation of HER2-amplified cells that harbor PIK3CA mutations with IC50 of <500 nM, and effectively inhibits both proliferation and viability of HER2-amplified breast cancer cells that are resistant to trastuzumab due to PTEN loss. [2] GDC-0941 significantly inhibits the growth of HCT116, DLD1 and HT29 cells with GI50 of 1081 nM, 1070 nM and 157 nM, respectively. [3] GDC-0941 inhibits tumor cell proliferation, induces apoptosis and suppresses centroblast population. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Sf9 NF3rTXlMcW6jc3WgRZN{[Xl? M2rmRVEhcA>? NX7QfpU3TE2VTx?= MVnJcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KFCLM1ugdFEyOGSnbIThJIV5eHKnc4Pl[EBqdiCVZkmgZ4VtdHNiY3;lfJBz\XO|aX7nJJA5PWGucHjhJJdqfGhiSVO1NEBw\iByLkCwN{DPxE1? MXKxPFc2PDZ3NB?=
Sf9 MWnLbY5ie2ViQYPzZZk> NFrIe2MyKGh? NGfQWFFFVVOR MV3Jcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KFCLM1ugdFEyOGKndHGgTFExPDdvUjDteZRidnRiZYjwdoV{e2WmIHnuJHNnQSClZXzsd{Bkd2W6cILld5NqdmdicEi1ZYxxcGFid3n0bEBKSzVyIH;mJFAvODB|IN88US=> M1\NcFE5PzV2NkW0
Sf9 NXTIWVJjU2mwYYPlJGF{e2G7 NVzX[o4yOSCq MWDEUXNQ MV;Jcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KFCLM1ugdFEyOGKndHGgSVU1PS2NIH31eIFvfCCneIDy[ZN{\WRiaX6gV4Y6KGOnbHzzJINw\XiycnXzd4lv\yCyOEXhcJBp[SC5aYToJGlEPTBib3[gNE4xODNizszN M{PPOlE5PzV2NkW0
Sf9 MULLbY5ie2ViQYPzZZk> MWqxJIg> NIjJXYdFVVOR NVP0W5lUUW6qaXLpeIlwdiCxZjDoeY1idiC{ZXPvcYJqdmGwdDDQTVNMKHBzMUDi[ZRiKGW6cILld5Nm\CCrbjDT[lkh[2WubIOgZ49mgHC{ZYPzbY5oKHB6NXHsdIhiKHerdHigTWM2OCCxZjCwMlA{OyEQvF2= MYGxPFc2PDZ3NB?=
Sf9 Mni4T4lv[XOnIFHzd4F6 MlHuNUBp M1nSTmROW09? NV7MVFFLUW6qaXLpeIlwdiCxZjDoeY1idiC{ZXPvcYJqdmGwdDDQTVNMKHBzMUDhcJBp[SCneIDy[ZN{\WRiaX6gV4Y6KGOnbHzzJINw\XiycnXzd4lv\yCyOEXhcJBp[Q>? M3PyXFE5PzV2NkW0
MDA-MB-361 MVvGeY5kfGmxbjDBd5NigQ>? MXWyJIg> MlP6SG1UVw>? NVnwbXNPUW6qaXLpeIlwdiCxZjDBb5QhW2W{NEezJJBpd3OyaH;yfYxifGmxbjDpckBpfW2jbjDNSGEuVUJvM{[xJINmdGy|IIfpeIghWEmNM1PBJGU2PDVvSzDteZRifGmxbjD3bZRpKEmFNUCgc4YhOC5yMkig{txO Mkj0NVg4PTR4NUS=
PC3 M{\F[mZ2dmO2aX;uJGF{e2G7 NYLYVYNqOiCq NFzleo5FVVOR MkLuTY5pcWKrdHnvckBw\iCDa4SgV4VzPDd|IIDoc5NxcG:{eXzheIlwdiCrbjDQWGVPNW63bHygbJVu[W5iUFOzJINmdGy|IIfpeIghUUN3MDDv[kAxNjB|NzFOwG0> NUX4OpQ2OTh5NUS2OVQ>
U87MG NGXIZnJHfW6ldHnvckBCe3OjeR?= NH3vOFgzKGh? M{LndWROW09? NXzWb21vUW6qaXLpeIlwdiCxZjDBb5QhW2W{NEezJJBpd3OyaH;yfYxifGmxbjDpckBRXEWQLX71cIwhcHWvYX6gWVg4VUdiY3XscJMhf2m2aDDJR|UxKG:oIECuNFQ3KM7:TR?= NUP3XnNbOTh5NUS2OVQ>
MDA-MB-361 M1jwfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;vPVYhcA>? MXXEUXNQ MYTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2GQT3NRk0{PjFiY3XscJMhf2m2aDDQTWs{S0FiRUW0OU1MKG23dHH0bY9vKHerdHigTWM2OCCxZjCwMlczKM7:TR?= MVKxPFc2PDZ3NB?=
A2780 M4LHXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWG5OkBp NXT5fHd7TE2VTx?= M3L5bmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQUK3PFAh[2WubIOge4l1cCCSSVuzR2Eh[W6mIGDUSW4hdXW2YYTpc44hf2m2aDDJR|UxKG:oIECuNVQh|ryP MUWxPFc2PDZ3NB?=
PC3 NWHJWWdNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mmf3PVYhcA>? M4rMUWROW09? MlXkTWM2OD1yLkK4JO69VQ>? M{DqbFE5PzV2NkW0
U87MG MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV7TdJhEQTZiaB?= NXTsPIxUTE2VTx?= M3vqdGlEPTB;MD65OUDPxE1? NGnZcXgyQDd3NE[1OC=>
Sf9 MWTLbY5ie2ViQYPzZZk> NWHBNXlzOzBibXnu M3y3dWROW09? MYXJcohq[mm2aX;uJI9nKGi3bXHuJHBKO0upYX3tZUBmgHC{ZYPz[YQh[XO|ZYPz[YQh[XNiYX3veY51KG:oIFHUVEBkd26|dX3l[EB4cXSqIFnDOVAhd2ZiMD6wOFIh|ryP MXmyNlU1QDN2Mh?=
RAW 264.7 NH\TeZNMcW6jc3WgRZN{[Xl? M3j4SFkxKG2rbh?= M1nYNmROW09? NF7EcmRKdmirYnn0bY9vKG:oIHj1cYFvKFCLM1vnZY1u[SCneIDy[ZN{\WRiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCDS2SgdIhwe3Cqb4L5cIF1cW:wIIfpeIghUUN3MDDv[kAxNjJ7ODFOwG0> M1\JUlIzPTR6M{Sy
Sf9 M{K0VWtqdmG|ZTDBd5NigQ>? MlXpNUBp NHvQbnBKdmirYnn0bY9vKG:oIFfTWE1nfXOnZDDoeY1idiC{ZXPvcYJqdmGwdDDQTVNM[mW2YTDlfJBz\XO|ZXSgbY4h[mGldXzveolzfXNiaX7m[YN1\WRiU1[5JINmdGy|IIfpeIghUUN3MDDv[kAxNjBzNzFOwG0> MUGyN|U1ODZ2NR?=
Sf9 NWPySW5vU2mwYYPlJGF{e2G7 NInQd5oyKGh? NE\FbZNKdmirYnn0bY9vKG:oIFfTWE1nfXOnZDDoeY1idiC{ZXPvcYJqdmGwdDDQTVNM\GWudHGg[ZhxemW|c3Xk NYeydWpKOjN3NEC2OFU>
Sf9 M{O4dmtqdmG|ZTDBd5NigQ>? M37QUFEhcA>? M2XOb2lvcGmkaYTpc44hd2ZiR2PUMYZ2e2WmIHj1cYFvKHKnY3;tZolv[W62IGDJN2to[W2vYTDlfJBz\XO|ZXS= NX2xXYQ5OjN3NEC2OFU>
Sf9 M4riRmtqdmG|ZTDBd5NigQ>? MV6xJIg> MmXaTY5pcWKrdHnvckBw\iCJU2St[pV{\WRiaIXtZY4hemWlb33ibY5idnRiUFmzT4FteGijIHX4dJJme3OnZB?= NGjqR24zOzV2ME[0OS=>
SKOV3 MnXTT4lv[XOnIFHzd4F6 NWjTeohiOSEQvF2= MV[xJIg> MUnEUXNQ M{TlfGlvcGmkaYTpc44hd2ZiUFmzT4FteGijIHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiQXv0JHNmejR5MzDwbI9{eGixconsZZRqd25? M1LQWFI{OzZyM{S4
MCF7 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUixJO69VQ>? NGnvVHU6PiCq NFO2cm5FVVOR M{\JOmdKPTB;MD6wO|AzKM7:TR?= NUTKOFR1OjN|NkCzOFg>
SKOV3 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUKxJO69VQ>? M4ruNVk3KGh? MV3EUXNQ NI[zV4RIUTVyPUCuNVQ4PiEQvF2= MXWyN|M3ODN2OB?=
PC3 NILi[3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2DselczKGh? M1vZXmROW09? M2jDV2lEPTB;MD6yPEDPxE1? MmfCNlE6QDF5MUS=
MCF7.1 MnT6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3LZV|czKGh? NGLaeWZFVVOR NXrufWh5SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNR2Y4NjFiY3XscJMh\XiycnXzd4lv\yCKRWKyJIdmdmVid3n0bEBKSzVyIH;mJFAvOjhizszN NHTKeGwzOTl6MUexOC=>
MCF7-neo/Her2 M1jNfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2TXZ|czKGh? M4HocGROW09? M1nPRmlEPTB;MD6yPUDPxE1? MlLaNlM3PjJ7MEO=
MCF7-neo/Her2 M{Xwc2tqdmG|ZTDBd5NigQ>? NFnvdnVKdmirYnn0bY9vKG:oIGDJN2tidHCqYTDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hd2ZiQVvUJJBpd3OyaH;yfYxifGmxbjDheEBUPDd|IIfpeIghUUN3MDDv[kAxNjByNzFOwG0> MYqyN|Y3OjlyMx?=
PC3 NV7ycJlVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mly0O|IhcA>? Ml\1SG1UVw>? NX3KdZZITUN3ME2wMlM1KM7:TR?= NV\QPJU1OjF7OEW2N|k>
MCF7.1 M2TNSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4X3PVczKGh? NVLHS5ZETE2VTx?= NIfHN3RCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3DSlcvOSClZXzsd{BmgHC{ZYPzbY5oKFCLM1vhcJBp[SCvdYThcpQhf2m2aDDFR|UxKG:oIECuN|kh|ryP NUPVclhWOjF7OEW2N|k>
PC3 NYjsfmpJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml7sO|IhcA>? NHvQfGxFVVOR NUjhd4N4SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDQR|Mh[2WubIOg[IVncWOrZX70JIlvKFCWRV6ge4l1cCCLQ{WwJI9nKDBwM{mg{txO NVO5fVlsOjByNUC2Olk>
MCF7.1 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnrCO|IhcA>? M3PYdWROW09? M2C4NGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVPGO{4yKGOnbHzzJIV5eHKnc4PpcochWEl|S3HsdIhiKG23dHHueEB4cXSqIFnDOVAhd2ZiMD6zOEDPxE1? MkeyNlAxPTB4Nkm=
MCF7.1 M1HDNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFPocZY4OiCq M4O3PGVEPTB;MD63NkDPxE1? NH7FNJYzODN2Nk[1Oi=>
NCI-H1975 MU\DfZRwfG:6aXOgRZN{[Xl? M2\RNFczKGh? NVnGWIJUUUN3ME2wMlI4KM7:TR?= MXmyN|A2QTV2NR?=
H460 MXfDfZRwfG:6aXOgRZN{[Xl? M4POSFczKGh? M2DNc2lEPTB;MD64O{DPxE1? M4PNOlI{ODV7NUS1
HT-29 NX;vZVU4S3m2b4TvfIlkKEG|c3H5 NX;KV2FMPzJiaB?= NULhcHRsUUN3ME2wMlY3KM7:TR?= MX[yN|A2QTV2NR?=
HepG2 NIjGenpEgXSxdH;4bYMhSXO|YYm= NWOzSlRyPzJiaB?= NWjYSGM5UUN3ME2xJO69VQ>? MknqNlMxPTl3NEW=
SGC7901 NEPjV3REgXSxdH;4bYMhSXO|YYm= NF;ZTXc4OiCq MW\JR|UxRTFwODFOwG0> NWDSbZBlOjNyNUm1OFU>
NCI-H226 NH6wNplEgXSxdH;4bYMhSXO|YYm= NVLj[po{PzJiaB?= NGKxbppKSzVyPUKuPUDPxE1? NI\BSFYzOzB3OUW0OS=>
A549 MWXDfZRwfG:6aXOgRZN{[Xl? NWW5WFR7PzJiaB?= NFy3OpBKSzVyPU[uPUDPxE1? NV;UelVGOjNyNUm1OFU>
U87MG MX;DfZRwfG:6aXOgRZN{[Xl? MlHGO|IhcA>? M2TTXGlEPTB;Nz63O{DPxE1? NYTHeXVyOjNyNUm1OFU>
HBC4 NELQbYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MknxcI9oT0l3ME2tOk4xOyCP M1;4NFIzOzN4MkS2
BSY1 NH25fYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVi0fpVudG:pR1m1NF0uPi57MDDN M4DXdVIzOzN4MkS2
HBC5 M{DzSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4PhXIxw\0eLNUC9MVYvPjBiTR?= NGKybWkzOjN|NkK0Oi=>
MCF7 M3z2U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUDsc4dIUTVyPT23MlM{KE1? MX:yNlM{PjJ2Nh?=
MDA-MB-231 NGHrXGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;Jc5NsdG:pR1m1NF0uPS52NjDN NULTfXF[OjJ|M{[yOFY>
U251 NXKzepllT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4\W[oxw\0eLNUC9MVUvPTBiTR?= MWiyNlM{PjJ2Nh?=
SF268 MlS5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoD5cI9oT0l3ME2tOU4{QSCP M{jnWVIzOzN4MkS2
SF295 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGTkO|Ntd2eJSUWwQU03NjN5IF2= NWXXe406OjJ|M{[yOFY>
SF539 NUfmbmtCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHsc4dIUTVyPT22MlUxKE1? MXuyNlM{PjJ2Nh?=
SNB75 MnvnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYHsc4dIUTVyPT23MlExKE1? NWfGeWh1OjJ|M{[yOFY>
SNB78 M3zBZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH2zVI5td2eJSUWwQU03NjV{IF2= M335PFIzOzN4MkS2
HCC2998 M1XvO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MorQcI9oT0l3ME2tOk4zQSCP MojZNlI{OzZ{NE[=
KM12 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfsc4dIUTVyPT21Mlc3KE1? M2T0c|IzOzN4MkS2
HT-29 Mk[0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mli3cI9oT0l3ME2tOk4{OCCP M1TpRlIzOzN4MkS2
HCT15 M4XrXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mon3cI9oT0l3ME2tOk4yOiCP M{WyWVIzOzN4MkS2
HCT116 NEDHNJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{fjRoxw\0eLNUC9MVUvQDdiTR?= NEPiUWMzOjN|NkK0Oi=>
NCI-H23 NFuyN4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkPTcI9oT0l3ME2tOU44OyCP MVeyNlM{PjJ2Nh?=
NCI-H226 M13QO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn73cI9oT0l3ME2tOk4zOSCP NUPpOXJlOjJ|M{[yOFY>
NCI-H522 MmPtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M13qNoxw\0eLNUC9MVYvPThiTR?= M{HGc|IzOzN4MkS2
NCI-H483 M4DzZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULJXGZCdG:pR1m1NF0uPi53NjDN MVuyNlM{PjJ2Nh?=
A549 MkDxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGq0fVBtd2eJSUWwQU03NjF3IF2= NWTQcGcxOjJ|M{[yOFY>
DMS273 M3\lUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlTkcI9oT0l3ME2tOk41OyCP NF\WdHYzOjN|NkK0Oi=>
DMS114 M1zuVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2\hNoxw\0eLNUC9MVUvQTJiTR?= MYGyNlM{PjJ2Nh?=
LOXIMVI NWLsWYgyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXTsc4dIUTVyPT22MlI6KE1? MofuNlI{OzZ{NE[=
OVCAR3 NELuTmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4jYRYxw\0eLNUC9MVYvPzFiTR?= M2HkVVIzOzN4MkS2
OVCAR4 NEnWfnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmTEcI9oT0l3ME2tOU44PiCP NEW3TIYzOjN|NkK0Oi=>
OVCAR5 NUjYTVV{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlqycI9oT0l3ME2tOk4zPiCP NGXPeWMzOjN|NkK0Oi=>
OVCAR8 M37FfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYPsc4dIUTVyPT21Mlc{KE1? NFnDb4QzOjN|NkK0Oi=>
SKOV3 NVzpWpJxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnHJcI9oT0l3ME2tOk42OiCP NYCzRXRCOjJ|M{[yOFY>
RXF631L MlHKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDsc4dIUTVyPT22Mlg5KE1? NEXpTHUzOjN|NkK0Oi=>
ACHN MnTxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVXZbWQ1dG:pR1m1NF0uPi5yNzDN MYiyNlM{PjJ2Nh?=
St-4 NVfyRog6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmTucI9oT0l3ME2tOU42PiCP NEPWfVkzOjN|NkK0Oi=>
MKN1 M3exSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFjMXIptd2eJSUWwQU04NjB6IF2= NELmfW4zOjN|NkK0Oi=>
MKN7 NVzZXIgxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXLsc4dIUTVyPT22MlUxKE1? NH;B[YkzOjN|NkK0Oi=>
MKN28 MmjWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY\nWlFXdG:pR1m1NF0uPS53MjDN NYjSfpJxOjJ|M{[yOFY>
MKN45 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVLPUWZvdG:pR1m1NF0uPi53NTDN MUeyNlM{PjJ2Nh?=
MKN74 NFjQPJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3;WfYxw\0eLNUC9MVYvODJiTR?= NFz3NoEzOjN|NkK0Oi=>
DU145 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXacI9oT0l3ME2tOU45PSCP NGrP[HUzOjN|NkK0Oi=>
PC3 MnHrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGO2VWZtd2eJSUWwQU03NjZ4IF2= M3m4NFIzOzN4MkS2
ES5 NYD1[5d3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTVyLkKxJI5O NEfKUG1USU6JRWK=
HH MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3HC[2lEPTB;MUGxMlA5KG6P NHXtU5FUSU6JRWK=
MHH-PREB-1 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1m5UWlEPTB;MUG0MlMhdk1? M2PTUXNCVkeHUh?=
NCI-H1770 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLyTWM2OD1zMkOuPFYhdk1? NHHycpdUSU6JRWK=
HuO9 MkjZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTJyNj6wNkBvVQ>? MYXTRW5ITVJ?
HAL-01 M1XYXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEH2ZndKSzVyPUKwOk44OyCwTR?= NYCzUI5lW0GQR1XS
NOS-1 NYnsUItvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\ZV2lEPTB;MkGxMlgzKG6P NXTsPZdbW0GQR1XS
HGC-27 M1XYfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1vqNmlEPTB;MkGyMlU4KG6P M3OxSXNCVkeHUh?=
NB69 NVqx[ppET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjhTWM2OD1{NEWuNlchdk1? NY\1ZYh6W0GQR1XS
RS4-11 M4OxVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVvJR|UxRTJ4MT63OkBvVQ>? NVLXOndZW0GQR1XS
DOK NHjJV5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWnUdFI1UUN3ME2zNFEvPyCwTR?= MmPKV2FPT0WU
LB2241-RCC M2Pyd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI\mOohKSzVyPUOwN{45PCCwTR?= MkH3V2FPT0WU
NCI-H1623 NYPCT4t4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3nkW2lEPTB;M{C0MlA5KG6P MoXnV2FPT0WU
YH-13 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\tOWlEPTB;M{C0MlMzKG6P Ml22V2FPT0WU
BPH-1 M2rZd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTNzNDDuUS=> MWrTRW5ITVJ?
AN3-CA MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTN2MD6zO{BvVQ>? MWrTRW5ITVJ?
ES7 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVLUfWhHUUN3ME2zOFEvQTlibl2= NYDOeI13W0GQR1XS
MDA-MB-175-VII NHrjSm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTN3Mj65NkBvVQ>? MoO0V2FPT0WU
GAMG M2S5U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVjvVId2UUN3ME2zO|AvQDVibl2= NY\weJdEW0GQR1XS
CHL-1 NWrLUXpQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlL2TWM2OD1|N{iuOlUhdk1? MY\TRW5ITVJ?
NB7 NHTibppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLNd5lzUUN3ME2zPFkvQDNibl2= MVHTRW5ITVJ?
MFE-280 NG\3c29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXjESJB6UUN3ME20NVgvOiCwTR?= MUHTRW5ITVJ?
HL-60 M{fqOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{HJPGlEPTB;NEK1Mlc2KG6P NEmxNm5USU6JRWK=
GCIY M2rF[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUfRVIxoUUN3ME20N|MvQCCwTR?= MUjTRW5ITVJ?
MDA-MB-361 NHGzeItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTR|OT6xN{BvVQ>? MkPlV2FPT0WU
LXF-289 NUfNdXJHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIfX[2NKSzVyPUS0PE4zPyCwTR?= NWLFXopNW0GQR1XS
NBsusSR MmPjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY\o[oNsUUN3ME20PFgvQDVibl2= MXTTRW5ITVJ?
KU-19-19 NFuzcHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF71eVBKSzVyPUWxOk4xPyCwTR?= Mn2xV2FPT0WU
A204 MlPGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTV{Mj6zN{BvVQ>? MljnV2FPT0WU
LB1047-RCC NHrPU|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmHlTWM2OD13MkKuPVMhdk1? M3\5UHNCVkeHUh?=
COLO-684 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3jJVmlEPTB;NUKzMlEyKG6P MXLTRW5ITVJ?
PA-1 MoXpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3L3cWlEPTB;NUOyMlQyKG6P NFy2cZRUSU6JRWK=
MG-63 NWSyc484T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{jsW2lEPTB;NUSxMlEyKG6P MXPTRW5ITVJ?
BHT-101 NV;qUFl1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLzWoc5UUN3ME21OFQvQTRibl2= MX\TRW5ITVJ?
NKM-1 M3jXcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\sTlQ3UUN3ME21PVMvODlibl2= NIL2RotUSU6JRWK=
T47D MmTyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWXBWoRmUUN3ME21PVcvPTZibl2= NV;hcpljW0GQR1XS
MOLT-4 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{D4TmlEPTB;NkKzMlYzKG6P MYPTRW5ITVJ?
IGROV-1 MnvRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV3TdmFzUUN3ME22N|QvOzFibl2= M{PBcnNCVkeHUh?=
ES4 MojlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTZ|OT61OEBvVQ>? MX7TRW5ITVJ?
HuO-3N1 NIf5WIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnv2TWM2OD14NEKuN|ghdk1? M1L6[nNCVkeHUh?=
NEC8 M33qe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFfTVY5KSzVyPU[1N{42PyCwTR?= M{nIfHNCVkeHUh?=
HO-1-N-1 MmnNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1m0[WlEPTB;NkW5MlE4KG6P NWfhcZpZW0GQR1XS
EPCL-272H MkDIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX2xS5NKUUN3ME22PFcvOjFibl2= MkewV2FPT0WU
D-263MG M{jaSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGe4fnZKSzVyPUexPE4yKG6P NEW4SmZUSU6JRWK=
MV-4-11 M{L1WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGHqWXpKSzVyPUeyOE4{OSCwTR?= NETyVldUSU6JRWK=
SK-NEP-1 NVixXYJMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1LUS2lEPTB;N{K1Mlk1KG6P Mn3HV2FPT0WU
SW872 Ml6zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1rYNWlEPTB;N{K3Mlg6KG6P NWPHcGdbW0GQR1XS
P30-OHK NF2ycJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEi3cXVKSzVyPUezNE44OSCwTR?= NUHyS411W0GQR1XS
OMC-1 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVPJR|UxRTd3MT6wPUBvVQ>? Mn\0V2FPT0WU
LoVo MmDNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE\FXWlKSzVyPUe3O{46KG6P NEixeFdUSU6JRWK=
LNCaP-Clone-FGC M3LYb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmq5TWM2OD15OU[uN|Qhdk1? MmrSV2FPT0WU
L-363 NYTFb25FT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmjWTWM2OD15OUiuOFIhdk1? NGLwNJhUSU6JRWK=
ES8 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRThzMD61NkBvVQ>? M1TIfnNCVkeHUh?=
697 NIj6fmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnTBTWM2OD16M{GuOVUhdk1? MmS2V2FPT0WU
HSC-3 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4mzdWlEPTB;OEO5MlU1KG6P MojzV2FPT0WU
H4 M3jmfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnzsTWM2OD16NUCuPFUhdk1? MknHV2FPT0WU
QIMR-WIL Ml\TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTh4NT6yJI5O MWXTRW5ITVJ?
OAW-42 M2LXWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\jPWlEPTB;OEeyMlE6KG6P NIPkfoZUSU6JRWK=
MCF7 MmrzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2DmUGlEPTB;OEm4MlU6KG6P NHfMRpRUSU6JRWK=
SCC-25 M{fYcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTlzND6xPUBvVQ>? MmPiV2FPT0WU
NCI-H1563 MorVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXvSVpdMUUN3ME25NVUvQTlibl2= MmXoV2FPT0WU
OVCAR-5 NHq5NZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXHJR|UxRTl2MD6xO{BvVQ>? M17Q[3NCVkeHUh?=
HDLM-2 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEi5do9KSzVyPUm0PU4zKG6P MYPTRW5ITVJ?
NB5 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTl3Nj62JI5O Mnr3V2FPT0WU
NCI-H292 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\JTWM2OD17N{SuN|Ihdk1? MV7TRW5ITVJ?
A101D MmXnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4CySGlEPTB;OUmwMlE6KG6P MWrTRW5ITVJ?
NCI-H1648 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF7KN2RKSzVyPUm5PE42OSCwTR?= NED5SXBUSU6JRWK=
EKVX NVLjeYxmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIPTWmZKSzVyPUGuNFEzQSEQvF2= Mle4V2FPT0WU
SW1710 M3zGUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXTiZWx3UUN3ME2xMlA1OjN|IN88US=> M3jCeXNCVkeHUh?=
WM-115 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTFwME[2OVYh|ryP Mm\SV2FPT0WU
CAL-54 M{P4bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHnm[mtKSzVyPUGuNFcxQDFizszN MX3TRW5ITVJ?
TGBC24TKB M1j1emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml;iTWM2OD1zLkC4NFQ2KM7:TR?= NFzoXZRUSU6JRWK=
NCI-H520 NHG3OGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYfofGs6UUN3ME2xMlA5QTZ5IN88US=> NGT3[WZUSU6JRWK=
D-423MG M2rTXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGH3d4NKSzVyPUGuNFk6PjJizszN M1HQOHNCVkeHUh?=
BFTC-905 MnKxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHrIXlVKSzVyPUGuNVM1PDlizszN NVrTR3ozW0GQR1XS
HT M{DoeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFPzV|VKSzVyPUGuNVM1PzhizszN Mm[3V2FPT0WU
CTB-1 NGrmd4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;HUmlEPTB;MT6xOFI6OyEQvF2= MXrTRW5ITVJ?
Hs-578-T NFKx[mRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVXMWo9YUUN3ME2xMlE6PTZ3IN88US=> Mk[0V2FPT0WU
HuH-7 MnTJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHnVUFRKSzVyPUGuNlA6PDlizszN MlPLV2FPT0WU
LB996-RCC M4\KRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYPJR|UxRTFwMkKxO|ch|ryP MYXTRW5ITVJ?
KYSE-270 NVPVZW1FT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGDtWHVKSzVyPUGuNlk4OzRizszN NWnjXW5rW0GQR1XS
A4-Fuk M{LaeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2rWVWlEPTB;MT6yPVk6OyEQvF2= MVnTRW5ITVJ?
A498 NEn6SZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnq1TWM2OD1zLkOwOFc1KM7:TR?= M3mwT3NCVkeHUh?=
SK-MEL-1 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlyyTWM2OD1zLkOwOlc6KM7:TR?= MlrMV2FPT0WU
AU565 NWnIPI16T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTFwM{G4OlMh|ryP NWPTeY9XW0GQR1XS
Saos-2 Ml:2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTFwM{OyNFUh|ryP MXfTRW5ITVJ?
A549 NULObmQxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\FTWM2OD1zLkO5PVch|ryP NGHKNXNUSU6JRWK=
BFTC-909 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTFwNEOzNFUh|ryP NF:zbmlUSU6JRWK=
MDA-MB-415 NUTtXnVrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEfsZ3lKSzVyPUGuOFg3QTJizszN MmmyV2FPT0WU
639-V MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Moj0TWM2OD1zLkWwNlQ2KM7:TR?= NUDTfW1OW0GQR1XS
A704 M{nyTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTFwNUC3PFUh|ryP M2H6Z3NCVkeHUh?=
PANC-03-27 NF6zb4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1TodWlEPTB;MT61NVQxQCEQvF2= MWTTRW5ITVJ?
SK-MEL-28 MknTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlfVTWM2OD1zLkW2NFg2KM7:TR?= M2PZ[XNCVkeHUh?=
Ramos-2G6-4C10 MlvOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTFwNkC3OFYh|ryP NETYUodUSU6JRWK=
HuP-T4 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXrJUVFIUUN3ME2xMlYxPzd6IN88US=> MWTTRW5ITVJ?
VA-ES-BJ Ml;xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfITWM2OD1zLk[xNlch|ryP MVzTRW5ITVJ?
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NCI-H441 NG\LTXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTJ3Lke0OlUh|ryP NIGyUnVUSU6JRWK=
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RKO MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFvOd2ZKSzVyPUK2Mlc3OzJizszN MYTTRW5ITVJ?
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NCI-H2452 NXzzc|VpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2njS2lEPTB;MkeuO|cyPiEQvF2= M{\aenNCVkeHUh?=
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KYSE-450 NUnWR3FVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmfnTWM2OD1{Nz65PFYzKM7:TR?= NEj4SGtUSU6JRWK=
S-117 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoLUTWM2OD1{OT6zPFU4KM7:TR?= MULTRW5ITVJ?
SW13 NFjzZ3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEDJTm1KSzVyPUK5Mlg2OTlizszN NFfnUFVUSU6JRWK=
ES3 M1rJcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTNyLkO3N|Mh|ryP NFfhfppUSU6JRWK=
HCT-116 M4nxTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTNyLkW1OVQh|ryP Mn3EV2FPT0WU
NCI-H1693 NHLUOGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlvaTWM2OD1|MD61PVQzKM7:TR?= NVfmNGhDW0GQR1XS
VM-CUB-1 Mnz0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF24S5dKSzVyPUOwMlY1OTNizszN MlXJV2FPT0WU
NCI-H2170 NHXGb4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUD6SIZyUUN3ME2zNU42Pzh2IN88US=> MUXTRW5ITVJ?
ALL-PO Mki4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{TOcGlEPTB;M{GuPFQzQCEQvF2= M3fjOXNCVkeHUh?=
NCI-H661 NIS5RWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWK5bnN3UUN3ME2zNk4xPjJ|IN88US=> MULTRW5ITVJ?
NCI-H2347 MkHRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHHsWmpKSzVyPUOyMlQ5OzdizszN Ml3EV2FPT0WU
FTC-133 M1XwbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUHOcYR1UUN3ME2zNk44ODZizszN MlvmV2FPT0WU
COLO-829 NIXzVGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJR|UxRTN|LkO0Olch|ryP NHnIdlRUSU6JRWK=
GOTO MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTN|LkWyOVgh|ryP NYfKUoJvW0GQR1XS
YAPC M4jO[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkXXTWM2OD1|Mz64NVU6KM7:TR?= M1;YRXNCVkeHUh?=
LCLC-103H MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWDiRXlZUUN3ME2zOE4yPjJ2IN88US=> NESzbFhUSU6JRWK=
SiHa M3KwNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTN2LkO4NVch|ryP NX\XeXA4W0GQR1XS
LK-2 NU\pSHNrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn7sTWM2OD1|ND61O|A5KM7:TR?= M4rXenNCVkeHUh?=
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NCI-SNU-1 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1HtWmlEPTB;M{WuNVc6KM7:TR?= M2qxVnNCVkeHUh?=
KNS-81-FD MlLVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH\LWXpKSzVyPUO1MlY3OyEQvF2= NHvESYNUSU6JRWK=
SCC-9 M4HMZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTN4LkexOFYh|ryP MV;TRW5ITVJ?
SH-4 NYfrS2JQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmHMTWM2OD1|Nj63N{DPxE1? M2D5cHNCVkeHUh?=
HCC-1954 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY\2OWVnUUN3ME2zO{4zPzJ7IN88US=> NWfYNFdGW0GQR1XS
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BE-13 MmnUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHrQRpNKSzVyPUO3MlcxOThizszN M2P2fnNCVkeHUh?=
COLO-678 NYrjcHJpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWHZWJFiUUN3ME2zO{46PDN5IN88US=> M4jaeXNCVkeHUh?=
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OAW-28 MlnOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWrS[llZUUN3ME2zPE43OzlizszN NUnyPYVqW0GQR1XS
CAMA-1 NI\3Z3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXKTWM2OD1|OD65OlkyKM7:TR?= M{TCcnNCVkeHUh?=
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A3-KAW MmjKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTRyLkO2OlEh|ryP NIXvNY9USU6JRWK=
SK-MEL-24 MnP3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmrTTWM2OD12MD61PVMyKM7:TR?= MUDTRW5ITVJ?
KYSE-140 M1nLUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVvJR|UxRTRyLkexOlUh|ryP M4fiSHNCVkeHUh?=
MOLT-16 NGW3b4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M33nNGlEPTB;NEGuNVU{PiEQvF2= M1;1cnNCVkeHUh?=
CFPAC-1 M17kdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmHaTWM2OD12Mj61NlEyKM7:TR?= M1rIOHNCVkeHUh?=
NB14 NFzIOZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTLT2V4UUN3ME20Nk44ODJ5IN88US=> NUHZR|JZW0GQR1XS
COLO-792 M4izTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnL6TWM2OD12Mj64PVYyKM7:TR?= M4DueXNCVkeHUh?=
RH-1 MnjNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4PXcmlEPTB;NEOuOFg{PiEQvF2= MYrTRW5ITVJ?
NCI-H522 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF\PcolKSzVyPUS0MlM2PjhizszN NHTzNYNUSU6JRWK=
Ca-Ski MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NULYcZVnUUN3ME20OE45OTF2IN88US=> NWLTRVNrW0GQR1XS
KGN NYrvbHlST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3Xt[GlEPTB;NEiuN|A3OyEQvF2= MUTTRW5ITVJ?
UACC-62 MlL4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4DtN2lEPTB;NEiuOFA4OiEQvF2= M1ewT3NCVkeHUh?=
NCI-H358 NEjvVWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3n0PWlEPTB;NEmuN|AyQCEQvF2= MWnTRW5ITVJ?
LS-411N MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVPPV4V5UUN3ME20PU4{OTF6IN88US=> MmntV2FPT0WU
IST-MES1 NXq5[4N5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;OUXVKSzVyPUS5MlU3OjVizszN MVTTRW5ITVJ?

... Click to View More Cell Line Experimental Data

In vivo GDC-0941 shows limited microsomal metabolism, resulting in 78% oral bioavailability [5]. Administration of GDC-0941 at 75 mg/kg/day displays significant inhibitory effect against established human U87MG glioblastoma xenografts in female NCr athymic mice, with tumor growth inhibition of 83%. [1] Oral administration of GDC-0941 at 150 mg/kg/day inhibits the growth of HER2-amplified, trastuzumab-resistant MDA-MB-361.1 xenografts in mice, and significantly delays the tumor progression, in association with potent induced apoptosis in tumors. [2] GDC-0941 (75 mg/kg/day) treatment for 2 weeks induces ~40% reduction in tumor volume of spontaneous B-cell follicular lymphomas developed in PTEN+/-LKB1+/hypo mice, accompanied by ablation of phosphorylation of Akt, S6K and SGK (serum and glucocorticoid protein kinase) protein kinases. [4]

Protocol

Kinase Assay:

[1]

+ Expand

Scintillation proximity assay:

Recombinant human PI3Kα, PI3Kβ, and PI3Kδ are coexpressed in a Sf9 baculovirus system with the p85α regulatory subunit and purified as GST-fusion proteins using affinity chromatography on glutathione-sepharose. Recombinant human PI3Kγ is expressed as monomeric GST-fusions and purified similarly. GDC-0941 is dissolved in DMSO and added to 20 mM Tris-HCl (pH 7.5) containing 200 μg yttrium silicate (Ysi) polylysine SPA beads, 4 mM MgCl2, 1 mM dithiothreitol (DTT), 1 μM ATP, 0.125 μCi [γ-33P]-ATP, and 4% (v/v) DMSO in a total volume of 50 μL. The recombinant GST-fusion of PI3Kα (5 ng), PI3Kβ (5 ng), PI3Kδ (5 ng), or PI3Kγ (5 ng) is added to the assay mixture to initiate the kinase reaction. After incubation for 1 hour at room temperature, the kinase reaction is terminated with 150 μL PBS. The mixture is then centrifuged for 2 minutes at 2000 rpm and read using a Wallac Microbeta counter. The reported IC50 values are calculated using a sigmoidal, dose-response curve fit in MDL Assay Explorer.
Cell Research:

[2]

+ Expand
  • Cell lines: SKBR-3, BT474-M1, AU-565, HCC-1419, ZR75-30, KPL-4, JIMT-1, BT474-EEI, HCC-1954, MCF-7, CALU-3, SKOV-3, and MKN-7 cells
  • Concentrations: Dissolved in DMSO, final concentrations ~10 μM
  • Incubation Time: 48 and 72 hours
  • Method:

    Cells are exposed to various concentrations of GDC-0941 for 48, and 72 hours. Proliferation/viability of cells is detected by using the CellTiter-Glo Luminescent Cell Viability Assay. The pAkt (Ser473), cleaved caspase-3, and cleaved PARP are analyzed by western blot. The Caspase-Glo 3/7 assay and the Cell Death Detection ELISAplus assay are used to detect caspase 3/7 activity, and apoptosis, respectively.


    (Only for Reference)
Animal Research:

[2]

+ Expand
  • Animal Models: NCR nude mice implanted with MDA-MB-361.1 cells, and SCID, C.B-17/IcrHsd-Prkdcscid mice implanted subcutaneously with BT474-M1 cells
  • Formulation: Dissolved in 10% DMSO, 5% Tween 20, 85% water
  • Dosages: ~150 mg/kg/day
  • Administration: Oral gavage
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 44 mg/mL (85.66 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order:
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
For best results, use promptly after mixing.
5mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 513.64
Formula

C23H27N7O3S2

CAS No. 957054-30-7
Storage powder
in solvent
Synonyms RG7321

Bio Calculators

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Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

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Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00999128 Completed Healthy Volunteers Genentech, Inc. October 26, 2009 Phase 1
NCT02092831 Completed Healthy Volunteer Genentech, Inc. April 2014 Phase 1
NCT01740336 Active, not recruiting Breast Cancer Genentech, Inc. February 2013 Phase 2
NCT01493843 Completed Non-Squamous Non-Small Cell Lung Cancer Genentech, Inc. January 2012 Phase 2
NCT01474668 Completed Healthy Volunteer Genentech, Inc. October 2011 Phase 1
NCT01437566 Completed Breast Cancer Genentech, Inc. October 2011 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID