Pictilisib (GDC-0941)

Catalog No.S1065 Synonyms: RG7321

Pictilisib (GDC-0941) Chemical Structure

Molecular Weight(MW): 513.64

Pictilisib (GDC-0941) is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM in cell-free assays, with modest selectivity against p110β (11-fold) and p110γ (25-fold). Phase 2.

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Cited by 57 Publications

7 Customer Reviews

  • Dual PI3K/BRAF inhibition upregulates BIM and enhances apoptosis in PTEN cells. A, left, Western blot of 1205Lu cells treated with PLX4720 (3 μmol/L, 48 hours), the PI3K inhibitor GDC-0941 (3 μmol/L, 48 hours), or both drugs in combination (PtG); right, immunofluorescence staining of BIM (green) and DAPI (blue) in PTEN cells following PLX4720 treatment (3 μmol/L, 48 hours), the PI3K inhibitor LY294002 (10 μmol/L, 48 hours), or both drugs in combination (PLXtLY). B, left, immunofluorescence staining of PTEN 1205Lu following combined inhibition (3 μmol/L PLX4720 t 10 μmol/L LY294002, 48hours) increases nuclear localization of FOXO3a (green). DAPI is shown in blue. Magnification 40. Right, combined inhibition (3 μmol/L PLX4720 t 10 μmol/L LY294002, 48 hours) increases PTEN WM793 BIM mRNA levels to those observed with single BRAF inhibition (3 μmol/L PLX4720, 48 hours) in the PTENt WM35. C, PTEN cells were treated with PLX4720 (3 μmol/L, 48 hours), GDC-0941 (3 μmol/L, 48hours), or a combination of the 2 drugs (3Pt3G) before Annexin-V staining was analyzed by flow cytometry (*, P < 0.05 between the drug combination and each inhibitor alone). D, combined BRAF/PI3K inhibitor treatment blocks the escape of 1205Lu cells (PTEN) from therapy. Spheroids of 1205Lu cells were treated with either PLX4720 alone (3 and 10 μmol/L: data shows 3 mmol/L), LY294002 (10 μmol/L) alone or a combination of the 2 drugs for 72 hours. In other studies, spheroids were treated with drugs for 72 hours and then allowed to recover for 120 hours. Micrograph shows viability staining (green= live cells, red= dead cells). Magnification 10×.

    Cancer Res 2011 71, 2750-2760. Pictilisib (GDC-0941) purchased from Selleck.

    Combination of rapamycin and PI-103 leads to the suppression of AKT phosphorylation (phospho-specific western blot). Mel-Juso and 518A2 cells were treated with GDC-0941 from 0.05–1 μmol/L alone and in combination with rapamycin (50 nmol/L) for 24 hours. Control treatment was with DMSO.

     

     

    J Inves Der 2010 131, 495-503. Pictilisib (GDC-0941) purchased from Selleck.

  • TGF-β induces mTORC2 activation. ( A ) NMuMG cells were treated with TGF-β for the indicated times before lysis and immunoblotting. (B ) NMuMG cells were treated or not with TGF-β for the indicated times, in the presence or absence of SB431542 or LY294002. Cell lysates were subjected to anti-Rictor immunoprecipitation, and the immunoprecipitates were subjected to in vitro kinase assays using kinase-inactive Akt1 as a substrate, before immunoblotting of the kinase reactions, immunoprecipitates and cell lysates. The left panels are from the same gel, without differential exposure. ( C ) NMuMG cells were treated or not with TGF-β or insulin for the indicated times, in the presence or absence of SB431542 or GDC-0941. The kinase activity of mTORC2 was then assessed as in B. The top panels are from the same gel, without differential exposure. (D) NMuMG cells were treated or not with TGF-β for the indicated times, in the presence or absence of SB431542 or LY294002. Cell lysates were subjected to immunoprecipitation using Rictor antibody, and/or immunoblotted.

    J Cell Sci 2012 125(Pt 5), 1259-73. Pictilisib (GDC-0941) purchased from Selleck.

    Effects of LY294002 and GDC-0941 on the high-glucose-induced plasma membrane translocation of DGK δ1. (A, C) HEK293 cells were transfected with pAcGFP-DGKδ1 or pAcGFP-C1 vector. After being glucose-starved for 2.5 h and the subsequent pretreatment with (A) 10 μM LY294002 (Sigma-Aldrich) or (C) 1 μM GDC-0941 (Selleck Chemicals) for 30 min, the cells were incubated with or without high glucose (25 mM) for 5 min. The cells were fixed with 3.7% formaldehyde and observed using confocal laser-scanning microscopy. Scale bar = 10 μm. (B, D) After treatment with (B) LY294002 or (D) GDC-0941, the percentages of cells exhibiting the translocation of AcGFP-tagged DGK δ 1 to the plasma membrane were scored. More than 20 cells ex-pressing AcGFP-tagged DGK δ1 were counted in each experiment. The results are the means ± S.D. of three independent experiments. The statistical significance was deter-mined using Student's t -test (** P < 0.01, *** P < 0.005)

    Biochim Biophys Acta 2012 1823, 2210-6. Pictilisib (GDC-0941) purchased from Selleck.

  • After starved in serum-free medium for 24h, Breast cancer cells incubated with the indicated concentrations of GDC-0941  for 3h,followed by 15-minute  stimulation of 100ng/ml EGF.

     

     

     

    Dr. Zhang of Tianjin Medical University. Pictilisib (GDC-0941) purchased from Selleck.

    We treated all of drugs in T47D which has a PI3KCA H1044R mutation with the concentration shown below for 1 hour and performed western blot analysis using antibodies to phospho-AKT(SERINE 472), and total AKT.

     

     

    Saraswati Sukumar of Johns Hopkins University School of Medicine. Pictilisib (GDC-0941) purchased from Selleck.

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    PI3K pathway signaling in GDC-0941 and MK-2206 treated MCF-7 derivatives with PIK3CA or  AKT1 mutations. Cells were grown in medium containing 5% FBS and treated with vehicle or increasing concentrations of GDC-0941 (0 nM, 50 nM, 100 nM, and 400 nM) or MK-2206 (0 nM, 100 nM, 250 nM, 1000 nM). After 24 hours of drug treatment, lysates were prepared and equal amounts of protein were load ed onto SDS-PAGE gels and blotted with the indicated antibodies.

    Pictilisib (GDC-0941) purchased from Selleck.

Purity & Quality Control

Choose Selective PI3K Inhibitors

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Notes:

2. For more details, such as half maximal inhibitory concentrations (IC50s) and working concentrations of each inhibitor, please click on the link of the inhibitor of interest.
3. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
4. Orange "√" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

Biological Activity

Description Pictilisib (GDC-0941) is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM in cell-free assays, with modest selectivity against p110β (11-fold) and p110γ (25-fold). Phase 2.
Targets
p110α [1]
(Cell-free assay)
p110δ [1]
(Cell-free assay)
p110β [1]
(Cell-free assay)
p110γ [1]
(Cell-free assay)
mTOR [1]
(Cell-free assay)
3 nM 3 nM 33 nM 75 nM 0.58 μM(Ki app)
In vitro

GDC-0941 is equipotent against PI3Kα and PI3Kδ as well as PI3Kα mutants E545-K and H1047-R, displaying modest levels of selectivity against PI3Kβ (10-fold) and PI3Kγ (25-fold), and greater levels of selectivity against members of PI3K class II, III, and IV, including C2β, Vps34, DNA-PK, and mTOR. GDC-0941 potently inhibits the phosphorylation of Akt in U87MG, PC3, and MDA-MB-361 cells with IC50 of 46 nM, 37 nM, and 28 nM, respectively. GDC-0941 inhibits the proliferation of U87MG, A2780, PC3, and MDA-MB-361 cells with IC50 of 0.95 μM, 0.14 μM, 0.28 μM, and 0.72 μM, respectively. [1] GDC-0941 treatment potently inhibits the proliferation of both trastuzumab-sensitive and -insensitive HER2-amplified cells with IC50 of 149-944 nM. GDC-0941 inhibits proliferation of HER2-amplified cells that harbor PIK3CA mutations with IC50 of <500 nM, and effectively inhibits both proliferation and viability of HER2-amplified breast cancer cells that are resistant to trastuzumab due to PTEN loss. [2] GDC-0941 significantly inhibits the growth of HCT116, DLD1 and HT29 cells with GI50 of 1081 nM, 1070 nM and 157 nM, respectively. [3] GDC-0941 inhibits tumor cell proliferation, induces apoptosis and suppresses centroblast population. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Sf9 MmPsT4lv[XOnIFHzd4F6 NX;oOIZwOSCq M13LSGROW09? Mn33TY5pcWKrdHnvckBw\iCqdX3hckBz\WOxbXLpcoFvfCCSSUPLJJAyOTCmZXz0ZUBmgHC{ZYPz[YQhcW5iU3[5JINmdGy|IHPv[ZhxemW|c3nu[{BxQDWjbIDoZUB4cXSqIFnDOVAhd2ZiMD6wNFMh|ryP MkjCNVg4PTR4NUS=
Sf9 M1\DcWtqdmG|ZTDBd5NigQ>? NEK0bWsyKGh? Ml;mSG1UVw>? MVXJcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KFCLM1ugdFEyOGKndHGgTFExPDdvUjDteZRidnRiZYjwdoV{e2WmIHnuJHNnQSClZXzsd{Bkd2W6cILld5NqdmdicEi1ZYxxcGFid3n0bEBKSzVyIH;mJFAvODB|IN88US=> M{fnSlE5PzV2NkW0
Sf9 M1HqNGtqdmG|ZTDBd5NigQ>? M1LjO|EhcA>? MkXESG1UVw>? M3TpcGlvcGmkaYTpc44hd2ZiaIXtZY4hemWlb33ibY5idnRiUFmzT{BxOTFyYnX0ZUBGPTR3LVugcZV1[W62IHX4dJJme3OnZDDpckBU\jliY3XscJMh[2:neIDy[ZN{cW6pIIC4OYFteGijIIfpeIghUUN3MDDv[kAxNjByMzFOwG0> NIHFPYMyQDd3NE[1OC=>
Sf9 NYfEZWpOU2mwYYPlJGF{e2G7 NILYVpQyKGh? M1z0U2ROW09? NX7pTWVVUW6qaXLpeIlwdiCxZjDoeY1idiC{ZXPvcYJqdmGwdDDQTVNMKHBzMUDi[ZRiKGW6cILld5Nm\CCrbjDT[lkh[2WubIOgZ49mgHC{ZYPzbY5oKHB6NXHsdIhiKHerdHigTWM2OCCxZjCwMlA{OyEQvF2= MY[xPFc2PDZ3NB?=
Sf9 NF;iWYxMcW6jc3WgRZN{[Xl? NYnOTYV6OSCq MWHEUXNQ MXvJcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KFCLM1ugdFEyOGGucHjhJIV5eHKnc4Pl[EBqdiCVZkmgZ4VtdHNiY3;lfJBz\XO|aX7nJJA5PWGucHjh MnHyNVg4PTR4NUS=
MDA-MB-361 NF7ocodHfW6ldHnvckBCe3OjeR?= MUSyJIg> M4\3TGROW09? MmP1TY5pcWKrdHnvckBw\iCDa4SgV4VzPDd|IIDoc5NxcG:{eXzheIlwdiCrbjDoeY1idiCPRFGtUWIuOzZzIHPlcIx{KHerdHigVGlMO0ODIFW1OFUuUyCvdYTheIlwdiC5aYToJGlEPTBib3[gNE4xOjhizszN MWOxPFc2PDZ3NB?=
PC3 MnrtSpVv[3Srb36gRZN{[Xl? MWKyJIg> MmTVSG1UVw>? MknPTY5pcWKrdHnvckBw\iCDa4SgV4VzPDd|IIDoc5NxcG:{eXzheIlwdiCrbjDQWGVPNW63bHygbJVu[W5iUFOzJINmdGy|IIfpeIghUUN3MDDv[kAxNjB|NzFOwG0> MVqxPFc2PDZ3NB?=
U87MG MY\GeY5kfGmxbjDBd5NigQ>? MWGyJIg> NHPRboRFVVOR MVTJcohq[mm2aX;uJI9nKEGtdDDT[ZI1PzNicHjvd5Bpd3K7bHH0bY9vKGmwIGDUSW4udnWubDDoeY1idiCXOEfNS{Bk\WyuczD3bZRpKEmFNUCgc4YhOC5yNE[g{txO MkHkNVg4PTR4NUS=
MDA-MB-361 M4HzUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWq5OkBp M1;Od2ROW09? MofvRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPRFGtUWIuOzZzIHPlcIx{KHerdHigVGlMO0ODIFW1OFUuUyCvdYTheIlwdiC5aYToJGlEPTBib3[gNE44OiEQvF2= M3XENlE5PzV2NkW0
A2780 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnnPVYhcA>? M2fNcWROW09? MVnBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEF{N{iwJINmdGy|IIfpeIghWEmNM1PBJIFv\CCSVFXOJI12fGG2aX;uJJdqfGhiSVO1NEBw\iByLkG0JO69VQ>? NXL4SYVEOTh5NUS2OVQ>
PC3 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYqwbGJVQTZiaB?= MWPEUXNQ NXPpe21QUUN3ME2wMlI5KM7:TR?= MUCxPFc2PDZ3NB?=
U87MG MmfqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1rxc|k3KGh? MXnEUXNQ NGi0SlZKSzVyPUCuPVUh|ryP NITRSVkyQDd3NE[1OC=>
Sf9 NH7peYxMcW6jc3WgRZN{[Xl? MX[zNEBucW5? M1LCXWROW09? NV;5XYZ4UW6qaXLpeIlwdiCxZjDoeY1idiCSSUPL[4FudWFiZYjwdoV{e2WmIHHzd4V{e2WmIHHzJIFud3WwdDDv[kBCXFBiY3;ud5Vu\WRid3n0bEBKSzVyIH;mJFAvODR{IN88US=> MlvzNlI2PDh|NEK=
RAW 264.7 Mnj3T4lv[XOnIFHzd4F6 NH[4bJU6OCCvaX6= MnzWSG1UVw>? NXS2OJBoUW6qaXLpeIlwdiCxZjDoeY1idiCSSUPL[4FudWFiZYjwdoV{e2WmIHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiQVvUJJBpd3OyaH;yfYxifGmxbjD3bZRpKEmFNUCgc4YhOC5{OUig{txO MnfzNlI2PDh|NEK=
Sf9 MlTnT4lv[XOnIFHzd4F6 NH6yWFMyKGh? NXvqOmEzUW6qaXLpeIlwdiCxZjDHV3Qu\nW|ZXSgbJVu[W5icnXjc41jcW6jboSgVGk{U2KndHGg[ZhxemW|c3XkJIlvKGKjY4Xsc5ZqenW|IHnu[oVkfGWmIGPGPUBk\WyuczD3bZRpKEmFNUCgc4YhOC5yMUeg{txO MmS1NlM2PDB4NEW=
Sf9 NFrCdYFMcW6jc3WgRZN{[Xl? NInSfXAyKGh? NVyySmhSUW6qaXLpeIlwdiCxZjDHV3Qu\nW|ZXSgbJVu[W5icnXjc41jcW6jboSgVGk{U2SnbIThJIV5eHKnc4Pl[C=> MUCyN|U1ODZ2NR?=
Sf9 NWTGelRxU2mwYYPlJGF{e2G7 MVyxJIg> MWLJcohq[mm2aX;uJI9nKEeVVD3meZNm\CCqdX3hckBz\WOxbXLpcoFvfCCSSUPL[4FudWFiZYjwdoV{e2Wm MYeyN|U1ODZ2NR?=
Sf9 Ml7sT4lv[XOnIFHzd4F6 M3zCUVEhcA>? NF\4fXpKdmirYnn0bY9vKG:oIFfTWE1nfXOnZDDoeY1idiC{ZXPvcYJqdmGwdDDQTVNM[WyyaHGg[ZhxemW|c3Xk M{PzbVI{PTRyNkS1
SKOV3 Mo\KT4lv[XOnIFHzd4F6 M1\zfVEh|ryP M4\UblEhcA>? NVvoNJp6TE2VTx?= NVvZcWc3UW6qaXLpeIlwdiCxZjDQTVNM[WyyaHGgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDBb5QhW2W{NEezJJBpd3OyaH;yfYxifGmxbh?= NYi3XmxlOjN|NkCzOFg>
MCF7 NWjlWnVtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLmboVxOSEQvF2= NX\lUolHQTZiaB?= M2r4SmROW09? MnLQS2k2OD1yLkC3NFIh|ryP M3:4XFI{OzZyM{S4
SKOV3 NVnTTFRGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIXuTlcyKM7:TR?= MVe5OkBp Ml7VSG1UVw>? MULHTVUxRTBwMUS3OkDPxE1? NWW1O3l5OjN|NkCzOFg>
PC3 Mo\zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEHIW5Y4OiCq MkLsSG1UVw>? NGfJemlKSzVyPUCuNlgh|ryP M2X5SVIyQThzN{G0
MCF7.1 Mn\kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFq1NI84OiCq NGXhZ5BFVVOR NG\T[Y5CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3DSlcvOSClZXzsd{BmgHC{ZYPzbY5oKEiHUkKg[4Vv\SC5aYToJGlEPTBib3[gNE4zQCEQvF2= NXG4VHN{OjF7OEG3NVQ>
MCF7-neo/Her2 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnH5O|IhcA>? MUnEUXNQ NGnOelhKSzVyPUCuNlkh|ryP NXHURWZlOjN4NkK5NFM>
MCF7-neo/Her2 MlPnT4lv[XOnIFHzd4F6 NXXXV4gzUW6qaXLpeIlwdiCxZjDQTVNM[WyyaHGgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKG:oIFHLWEBxcG:|cHjvdplt[XSrb36gZZQhWzR5MzD3bZRpKEmFNUCgc4YhOC5yMEeg{txO NH7D[HkzOzZ4MkmwNy=>
PC3 NUPoNYYxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGXWZY84OiCq M3XV[GROW09? M2fKV2VEPTB;MD6zOEDPxE1? NHHpW4IzOTl6NU[zPS=>
MCF7.1 MkmxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NITFO2w4OiCq M3HqWmROW09? NFq1VIJCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3DSlcvOSClZXzsd{BmgHC{ZYPzbY5oKFCLM1vhcJBp[SCvdYThcpQhf2m2aDDFR|UxKG:oIECuN|kh|ryP MVuyNVk5PTZ|OR?=
PC3 NIfiSldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\l[|czKGh? NYjtVGtUTE2VTx?= MWPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFCFMzDj[YxteyCmZX\pZ4lmdnRiaX6gVHRGViC5aYToJGlEPTBib3[gNE4{QSEQvF2= MXOyNFA2ODZ4OR?=
MCF7.1 NXzZWGF2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIHuO5c4OiCq MXjEUXNQ NYDFTpBwSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNR2Y4NjFiY3XscJMh\XiycnXzd4lv\yCSSUPLZYxxcGFibYX0ZY51KHerdHigTWM2OCCxZjCwMlM1KM7:TR?= NFrodo8zODB3ME[2PS=>
MCF7.1 NWr1OllpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoLXO|IhcA>? MV3FR|UxRTBwN{Kg{txO M3fTXlIxOzR4NkW2
NCI-H1975 MVPDfZRwfG:6aXOgRZN{[Xl? Mn\QO|IhcA>? NHTCT|FKSzVyPUCuNlch|ryP NFjY[lAzOzB3OUW0OS=>
H460 MVXDfZRwfG:6aXOgRZN{[Xl? NYLuNINiPzJiaB?= NIC0OWFKSzVyPUCuPFch|ryP MX6yN|A2QTV2NR?=
HT-29 NF;kfFNEgXSxdH;4bYMhSXO|YYm= M4TNVlczKGh? NHzzc2tKSzVyPUCuOlYh|ryP MXSyN|A2QTV2NR?=
HepG2 M3PpSWN6fG:2b4jpZ{BCe3OjeR?= NEXMRnQ4OiCq NYPse5U4UUN3ME2xJO69VQ>? MnTQNlMxPTl3NEW=
SGC7901 NFXKOZdEgXSxdH;4bYMhSXO|YYm= Mom5O|IhcA>? MYXJR|UxRTFwODFOwG0> MkHWNlMxPTl3NEW=
NCI-H226 NUW5V3BjS3m2b4TvfIlkKEG|c3H5 NIjwVXA4OiCq NWPDXIllUUN3ME2yMlkh|ryP NYXhVnJrOjNyNUm1OFU>
A549 NXyxW3RyS3m2b4TvfIlkKEG|c3H5 MlTFO|IhcA>? NGm2XmRKSzVyPU[uPUDPxE1? M1f6fFI{ODV7NUS1
U87MG MmXQR5l1d3SxeHnjJGF{e2G7 Ml\GO|IhcA>? MX;JR|UxRTdwN{eg{txO MlzJNlMxPTl3NEW=
HBC4 NGLoU5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPsc4dIUTVyPT22MlA{KE1? MXOyNlM{PjJ2Nh?=
BSY1 NGDjc2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7sc4dIUTVyPT22MlkxKE1? MlLmNlI{OzZ{NE[=
HBC5 Mmf1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnsc4dIUTVyPT22MlYxKE1? NVTuVZlbOjJ|M{[yOFY>
MCF7 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2DNN4xw\0eLNUC9MVcvOzNiTR?= MXOyNlM{PjJ2Nh?=
MDA-MB-231 NIC2RmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MorhcI9oT0l3ME2tOU41PiCP M3T2TlIzOzN4MkS2
U251 M2HGRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIPOTGVtd2eJSUWwQU02NjVyIF2= NH3CUIYzOjN|NkK0Oi=>
SF268 MlnrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;HNFhtd2eJSUWwQU02NjN7IF2= NFKyXW0zOjN|NkK0Oi=>
SF295 M1[wXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnfCcI9oT0l3ME2tOk4{PyCP M3;IWVIzOzN4MkS2
SF539 MonjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjsc4dIUTVyPT22MlUxKE1? M4rzZlIzOzN4MkS2
SNB75 Ml7NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjFcI9oT0l3ME2tO{4yOCCP MXOyNlM{PjJ2Nh?=
SNB78 NF:xSpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULsc4dIUTVyPT22MlUzKE1? NYHzb|FWOjJ|M{[yOFY>
HCC2998 M3vuemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnu2cI9oT0l3ME2tOk4zQSCP NVrZephbOjJ|M{[yOFY>
KM12 NXHPenpUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHfHVWFtd2eJSUWwQU02Njd4IF2= MUOyNlM{PjJ2Nh?=
HT-29 Ml;SS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHnFNVhtd2eJSUWwQU03NjNyIF2= MmTPNlI{OzZ{NE[=
HCT15 M{DHSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGW1ZVRtd2eJSUWwQU03NjF{IF2= M3nXVlIzOzN4MkS2
HCT116 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrsc4dIUTVyPT21Mlg4KE1? NIXMN4QzOjN|NkK0Oi=>
NCI-H23 M{GwO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIXIc|Jtd2eJSUWwQU02Njd|IF2= NEe3Z3QzOjN|NkK0Oi=>
NCI-H226 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkjCcI9oT0l3ME2tOk4zOSCP NVrOc5JzOjJ|M{[yOFY>
NCI-H522 NYmwT45LT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWXOO4x[dG:pR1m1NF0uPi53ODDN MYiyNlM{PjJ2Nh?=
NCI-H483 MnHUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIjXcpNtd2eJSUWwQU03NjV4IF2= MUCyNlM{PjJ2Nh?=
A549 NWTqbYEyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHjqPYltd2eJSUWwQU03NjF3IF2= NV;INpBrOjJ|M{[yOFY>
DMS273 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUHNTndpdG:pR1m1NF0uPi52MzDN M1ziU|IzOzN4MkS2
DMS114 NYTy[XlJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEew[pdtd2eJSUWwQU02Njl{IF2= M3\sR|IzOzN4MkS2
LOXIMVI NV6wNI9vT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmH2cI9oT0l3ME2tOk4zQSCP NHS3VnAzOjN|NkK0Oi=>
OVCAR3 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2SwdYxw\0eLNUC9MVYvPzFiTR?= MWSyNlM{PjJ2Nh?=
OVCAR4 NUHTS5dxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFHESmJtd2eJSUWwQU02Njd4IF2= NYDDSI1YOjJ|M{[yOFY>
OVCAR5 NHPybphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlH1cI9oT0l3ME2tOk4zPiCP Mm\pNlI{OzZ{NE[=
OVCAR8 M{PKfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\YcI9oT0l3ME2tOU44OyCP MU[yNlM{PjJ2Nh?=
SKOV3 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIfJSZltd2eJSUWwQU03NjV{IF2= MU[yNlM{PjJ2Nh?=
RXF631L NXzYZZU6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\sc4dIUTVyPT22Mlg5KE1? NVL4TGdmOjJ|M{[yOFY>
ACHN NEPUdJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\xcI9oT0l3ME2tOk4xPyCP M1jE[VIzOzN4MkS2
St-4 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkS1cI9oT0l3ME2tOU42PiCP NVPZfpJjOjJ|M{[yOFY>
MKN1 Mnm3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3sc4dIUTVyPT23MlA5KE1? NUG5OmlYOjJ|M{[yOFY>
MKN7 NF;wOVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\4bm1OdG:pR1m1NF0uPi53MDDN M{XibFIzOzN4MkS2
MKN28 M2jwe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVjlVoJMdG:pR1m1NF0uPS53MjDN MWSyNlM{PjJ2Nh?=
MKN45 M1v2O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVi1NYx7dG:pR1m1NF0uPi53NTDN Mkn3NlI{OzZ{NE[=
MKN74 M2PqXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M17heoxw\0eLNUC9MVYvODJiTR?= M3jqSFIzOzN4MkS2
DU145 NV2zRoJrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlrwcI9oT0l3ME2tOU45PSCP Ml\LNlI{OzZ{NE[=
PC3 M{D6dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmjTcI9oT0l3ME2tOk43PiCP MnTZNlI{OzZ{NE[=
ES5 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnPWTWM2OD13MD6yNUBvVQ>? Mmr1V2FPT0WU
HH M1ewVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDWSVBbUUN3ME2xNVEvODhibl2= NE\MTo9USU6JRWK=
MHH-PREB-1 NFK3bo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTFzND6zJI5O MlPhV2FPT0WU
NCI-H1770 M4rOWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYTGO44zUUN3ME2xNlMvQDZibl2= NVvPXJpyW0GQR1XS
HuO9 MoXkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M13O[GlEPTB;MkC2MlAzKG6P NUXYTnQ{W0GQR1XS
HAL-01 NVjK[IdKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTJyNj63N{BvVQ>? NGfRWGNUSU6JRWK=
NOS-1 MkLQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTJzMT64NkBvVQ>? Mnr0V2FPT0WU
HGC-27 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{PGbmlEPTB;MkGyMlU4KG6P MofEV2FPT0WU
NB69 NXW2WnN2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3HNfmlEPTB;MkS1MlI4KG6P NHfhdmlUSU6JRWK=
RS4-11 M3;LNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4TCemlEPTB;Mk[xMlc3KG6P NVf4dFZjW0GQR1XS
DOK M3nDN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRTNyMT63JI5O NELYR|VUSU6JRWK=
LB2241-RCC NFriWY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUPwVVR[UUN3ME2zNFMvQDRibl2= NY\4UIhCW0GQR1XS
NCI-H1623 M1i1dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHHTWM2OD1|MESuNFghdk1? MVXTRW5ITVJ?
YH-13 MkjIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTNyND6zNkBvVQ>? NH3vfY5USU6JRWK=
BPH-1 MofvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTNzNDDuUS=> NUXQSlJ1W0GQR1XS
AN3-CA MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoPBTWM2OD1|NECuN|chdk1? M1;qbHNCVkeHUh?=
ES7 MmfKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFPB[4RKSzVyPUO0NU46QSCwTR?= M1PvfHNCVkeHUh?=
MDA-MB-175-VII NEf2em5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3faTGlEPTB;M{WyMlkzKG6P M3vhZ3NCVkeHUh?=
GAMG M1juOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIDRUoVKSzVyPUO3NE45PSCwTR?= NFHER3dUSU6JRWK=
CHL-1 Ml7VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3S1WGlEPTB;M{e4MlY2KG6P NIfMWmNUSU6JRWK=
NB7 NVvRfWVoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmTLTWM2OD1|OEmuPFMhdk1? NUjCT2RIW0GQR1XS
MFE-280 NXryUlBOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUXKWo5LUUN3ME20NVgvOiCwTR?= NXvDfXEyW0GQR1XS
HL-60 Mlv4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3nnRWlEPTB;NEK1Mlc2KG6P NF3QXZBUSU6JRWK=
GCIY NHvlRYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTR|Mz64JI5O NGPmOYhUSU6JRWK=
MDA-MB-361 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTR|OT6xN{BvVQ>? NGXNUpVUSU6JRWK=
LXF-289 NYG3[3dDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWroblJlUUN3ME20OFgvOjdibl2= MkTvV2FPT0WU
NBsusSR MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX3JR|UxRTR6OD64OUBvVQ>? MlfYV2FPT0WU
KU-19-19 NXLB[I1tT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2DnOWlEPTB;NUG2MlA4KG6P MUfTRW5ITVJ?
A204 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3j1eGlEPTB;NUKyMlM{KG6P MofFV2FPT0WU
LB1047-RCC MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF34NHlKSzVyPUWyNk46OyCwTR?= NXnsXJFYW0GQR1XS
COLO-684 NICwZnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MonaTWM2OD13MkOuNVEhdk1? M13KTXNCVkeHUh?=
PA-1 NUPUUmNET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3rK[2lEPTB;NUOyMlQyKG6P MY\TRW5ITVJ?
MG-63 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mor6TWM2OD13NEGuNVEhdk1? MXvTRW5ITVJ?
BHT-101 NHzxOHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTV2ND65OEBvVQ>? Mn65V2FPT0WU
NKM-1 MmrGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEfXT|BKSzVyPUW5N{4xQSCwTR?= MnzSV2FPT0WU
T47D MlrmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF7DXopKSzVyPUW5O{42PiCwTR?= MWrTRW5ITVJ?
MOLT-4 MlnoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnPhTWM2OD14MkOuOlIhdk1? MlfkV2FPT0WU
IGROV-1 NWnEPGRwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTZ|ND6zNUBvVQ>? NF\CNJNUSU6JRWK=
ES4 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHvQcWlKSzVyPU[zPU42PCCwTR?= M{TqSnNCVkeHUh?=
HuO-3N1 M{\4bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn6wTWM2OD14NEKuN|ghdk1? Ml;yV2FPT0WU
NEC8 M3OyfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX3JR|UxRTZ3Mz61O{BvVQ>? MkjKV2FPT0WU
HO-1-N-1 NFvD[2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTZ3OT6xO{BvVQ>? M3fxPXNCVkeHUh?=
EPCL-272H Mk\vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGrPPGVKSzVyPU[4O{4zOSCwTR?= NF76O|FUSU6JRWK=
D-263MG MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEjLephKSzVyPUexPE4yKG6P M{CxOXNCVkeHUh?=
MV-4-11 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWe5d5FmUUN3ME23NlQvOzFibl2= M1qwcXNCVkeHUh?=
SK-NEP-1 NUm5O3pNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTd{NT65OEBvVQ>? NHK1dmJUSU6JRWK=
SW872 M{jGRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTd{Nz64PUBvVQ>? M1To[3NCVkeHUh?=
P30-OHK NWXEeIg4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVizdVZbUUN3ME23N|AvPzFibl2= MkLtV2FPT0WU
OMC-1 M{Pve2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVPHR2o3UUN3ME23OVEvODlibl2= NF;yO2tUSU6JRWK=
LoVo NIi3[|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUXNSJJDUUN3ME23O|cvQSCwTR?= NUTzTYxHW0GQR1XS
LNCaP-Clone-FGC NGHRcmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\oSWlEPTB;N{m2MlM1KG6P MYTTRW5ITVJ?
L-363 M3vObWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MonjTWM2OD15OUiuOFIhdk1? Ml21V2FPT0WU
ES8 M{n1dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\wTWM2OD16MUCuOVIhdk1? MULTRW5ITVJ?
697 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoSwTWM2OD16M{GuOVUhdk1? MXTTRW5ITVJ?
HSC-3 MnG0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJR|UxRTh|OT61OEBvVQ>? NWW2[ocyW0GQR1XS
H4 MmDyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1P2R2lEPTB;OEWwMlg2KG6P NYrGXGd6W0GQR1XS
QIMR-WIL NG\zdGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{T1RmlEPTB;OE[1MlIhdk1? MkTNV2FPT0WU
OAW-42 Mn3sS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTh5Mj6xPUBvVQ>? MkTzV2FPT0WU
MCF7 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlfMTWM2OD16OUiuOVkhdk1? M1PZVnNCVkeHUh?=
SCC-25 NUXyNG1ZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmKyTWM2OD17MUSuNVkhdk1? M2DMVnNCVkeHUh?=
NCI-H1563 NUCwWJRmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYnFfGhlUUN3ME25NVUvQTlibl2= MXvTRW5ITVJ?
OVCAR-5 NY\5dYk3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXnqO5I1UUN3ME25OFAvOTdibl2= M4nHPHNCVkeHUh?=
HDLM-2 NHixXIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXPVOmh1UUN3ME25OFkvOiCwTR?= NVvydId7W0GQR1XS
NB5 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXnQNVlxUUN3ME25OVYvPiCwTR?= Mo[yV2FPT0WU
NCI-H292 M1zHNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTl5ND6zNkBvVQ>? NVfTdHprW0GQR1XS
A101D M1TZN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{DENmlEPTB;OUmwMlE6KG6P NVfuXGdDW0GQR1XS
NCI-H1648 NHXueFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmHvTWM2OD17OUiuOVEhdk1? NVnoVJZ4W0GQR1XS
EKVX MmrhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWKyV3RKUUN3ME2xMlAyOjlizszN Ml\tV2FPT0WU
SW1710 M3K3dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTSTWM2OD1zLkC0NlM{KM7:TR?= NHHOZWRUSU6JRWK=
WM-115 Mo\XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV6yV3BVUUN3ME2xMlA3PjV4IN88US=> NULYdFNmW0GQR1XS
CAL-54 NYLtWo52T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUfDb3RyUUN3ME2xMlA4ODhzIN88US=> NUHvUXpGW0GQR1XS
TGBC24TKB NVrXZYNHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUDqfFBTUUN3ME2xMlA5ODR3IN88US=> NFfhfVlUSU6JRWK=
NCI-H520 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnyxTWM2OD1zLkC4PVY4KM7:TR?= NF3YRZNUSU6JRWK=
D-423MG NEH2O|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH;yNWtKSzVyPUGuNFk6PjJizszN M1zBOHNCVkeHUh?=
BFTC-905 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXjPY52UUN3ME2xMlE{PDR7IN88US=> M2CwbXNCVkeHUh?=
HT NHvYcW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2nsWmlEPTB;MT6xN|Q4QCEQvF2= M13ZSnNCVkeHUh?=
CTB-1 Mn3NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIrlWoRKSzVyPUGuNVQzQTNizszN MXLTRW5ITVJ?
Hs-578-T NVXJb5ZpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\G[I5UUUN3ME2xMlE6PTZ3IN88US=> MoDjV2FPT0WU
HuH-7 NILMOoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEnJTWxKSzVyPUGuNlA6PDlizszN MX3TRW5ITVJ?
LB996-RCC M4nab2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTFwMkKxO|ch|ryP NICzbHNUSU6JRWK=
KYSE-270 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHvPfoFKSzVyPUGuNlk4OzRizszN NXi1UplsW0GQR1XS
A4-Fuk MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEPtV49KSzVyPUGuNlk6QTNizszN M1TpTXNCVkeHUh?=
A498 M37Be2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFvpWJZKSzVyPUGuN|A1PzRizszN NFTU[WpUSU6JRWK=
SK-MEL-1 Mof3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MonITWM2OD1zLkOwOlc6KM7:TR?= NHizd49USU6JRWK=
AU565 NVraVWFwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHTTWM2OD1zLkOxPFY{KM7:TR?= M4DOcnNCVkeHUh?=
Saos-2 Mor3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFnZPJFKSzVyPUGuN|MzODVizszN NHLlRnFUSU6JRWK=
A549 MkfYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXLFbVVbUUN3ME2xMlM6QTdizszN MVvTRW5ITVJ?
BFTC-909 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4jFN2lEPTB;MT60N|MxPSEQvF2= NYfWTJNjW0GQR1XS
MDA-MB-415 MlX2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTFwNEi2PVIh|ryP NUXa[|dqW0GQR1XS
639-V MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnH0TWM2OD1zLkWwNlQ2KM7:TR?= MlrHV2FPT0WU
A704 M{fwVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEnVSHVKSzVyPUGuOVA4QDVizszN MVrTRW5ITVJ?
PANC-03-27 NFHVOGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTFwNUG0NFgh|ryP NVLpfVVCW0GQR1XS
SK-MEL-28 MlHOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1TLWmlEPTB;MT61OlA5PSEQvF2= NHv0fYhUSU6JRWK=
Ramos-2G6-4C10 MnO1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTFwNkC3OFYh|ryP MVzTRW5ITVJ?
HuP-T4 MlfvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfLTWM2OD1zLk[wO|c5KM7:TR?= NXPic2dTW0GQR1XS
VA-ES-BJ NYfwcIdmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYXONHVNUUN3ME2xMlYyOjdizszN MXXTRW5ITVJ?
EFM-19 NV\vS4d3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1HyVmlEPTB;MT62NVgyKM7:TR?= M17JNHNCVkeHUh?=
G-401 M1Lu[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mly4TWM2OD1zLk[yNVY1KM7:TR?= MnL5V2FPT0WU
D-566MG MmXnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlnVTWM2OD1zLk[yOVMh|ryP Ml3YV2FPT0WU
JVM-3 NV24b4pRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTFwNkS4O|Uh|ryP M13nVnNCVkeHUh?=
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NCI-H727 NV\l[o02T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2DZPGlEPTB;MUmuN|I6PSEQvF2= Mk\yV2FPT0WU
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HT-1197 M{jvZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2LmOWlEPTB;MkCuNlk2QCEQvF2= NFn5V4lUSU6JRWK=
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HD-MY-Z MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoG0TWM2OD1{MT6zOlk3KM7:TR?= MVnTRW5ITVJ?
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NCI-H1650 NHr2dHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmnWTWM2OD1{Mz65NlQyKM7:TR?= NGTnWJFUSU6JRWK=
ACHN MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvYTWM2OD1{ND60OlU3KM7:TR?= M1;vWXNCVkeHUh?=
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AM-38 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTJ3LkS4NUDPxE1? MYDTRW5ITVJ?
KG-1 NVHUVpJqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnG3TWM2OD1{NT61OFk1KM7:TR?= Mn61V2FPT0WU
COLO-824 M{LKSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHG4fY9KSzVyPUK1MlU2QTlizszN M4r2dXNCVkeHUh?=
NCI-H1155 M{\RXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkDpTWM2OD1{NT61PFQ4KM7:TR?= MWLTRW5ITVJ?
NCI-H441 NInyVoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\DTWM2OD1{NT63OFY2KM7:TR?= M4n6RXNCVkeHUh?=
J-RT3-T3-5 NH3vUGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTJ4LkOwNlch|ryP M4jPenNCVkeHUh?=
JEG-3 NUi3[oh[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX\uNXJ4UUN3ME2yOk43QDB3IN88US=> NEX4NnlUSU6JRWK=
RKO NE[yTlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTJ4Lke2N|Ih|ryP NVzEcJVIW0GQR1XS
CAL-85-1 NVywd|J[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWThcpBXUUN3ME2yO{4zOTF6IN88US=> M3K4NnNCVkeHUh?=
CAL-120 Mne1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml30TWM2OD1{Nz62PVE1KM7:TR?= NY[wTYRxW0GQR1XS
NCI-H2452 MlyyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\BWmlEPTB;MkeuO|cyPiEQvF2= MWjTRW5ITVJ?
NCI-H1395 NUXFZ4JZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWf3dGNHUUN3ME2yO{44QDN|IN88US=> NGnrbJdUSU6JRWK=
KYSE-450 M37ofWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX3JR|UxRTJ5Lkm4OlIh|ryP M1nOeHNCVkeHUh?=
S-117 M1\CVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTJ7LkO4OVch|ryP NXXL[oZ7W0GQR1XS
SW13 MmfyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTJ7Lki1NVkh|ryP M2LMRXNCVkeHUh?=
ES3 MoDUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlfoTWM2OD1|MD6zO|M{KM7:TR?= MWnTRW5ITVJ?
HCT-116 M3rue2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mly3TWM2OD1|MD61OVU1KM7:TR?= M2fTcnNCVkeHUh?=
NCI-H1693 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M33ZTmlEPTB;M{CuOVk1OiEQvF2= MUjTRW5ITVJ?
VM-CUB-1 MnvuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEHvSY5KSzVyPUOwMlY1OTNizszN MVjTRW5ITVJ?
NCI-H2170 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3HMXmlEPTB;M{GuOVc5PCEQvF2= M{DOc3NCVkeHUh?=
ALL-PO NHy3RZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTNzLki0Nlgh|ryP MmqwV2FPT0WU
NCI-H661 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1f5cWlEPTB;M{KuNFYzOyEQvF2= NGjhcWxUSU6JRWK=
NCI-H2347 NGOwNHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlLsTWM2OD1|Mj60PFM4KM7:TR?= NHHwS3pUSU6JRWK=
FTC-133 Mn:xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\pcGlEPTB;M{KuO|A3KM7:TR?= NXnqTYdwW0GQR1XS
COLO-829 M{nIV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmqzTWM2OD1|Mz6zOFY4KM7:TR?= NWf4dFdkW0GQR1XS
GOTO NWPpSVd7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2TYbWlEPTB;M{OuOVI2QCEQvF2= M4D0VHNCVkeHUh?=
YAPC NH;5Z4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTN|LkixOVkh|ryP MorUV2FPT0WU
LCLC-103H MoDhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUTuc4cyUUN3ME2zOE4yPjJ2IN88US=> MXXTRW5ITVJ?
SiHa M4H1RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTN2LkO4NVch|ryP NVPuN4dEW0GQR1XS
LK-2 M2K4OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M370SGlEPTB;M{SuOVcxQCEQvF2= NVLCdmNxW0GQR1XS
KP-N-YS MlnGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nZS2lEPTB;M{SuO|IxOiEQvF2= MkPxV2FPT0WU
NCI-SNU-1 M3e2TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW\JR|UxRTN3LkG3PUDPxE1? Ml;qV2FPT0WU
KNS-81-FD NUHm[GdXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFPUNWFKSzVyPUO1MlY3OyEQvF2= M4\qXHNCVkeHUh?=
SCC-9 NVjXO2NKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NITu[HFKSzVyPUO2MlcyPDZizszN NXTFPIlyW0GQR1XS
SH-4 NIHKOnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXoTWM2OD1|Nj63N{DPxE1? MmntV2FPT0WU
HCC-1954 NULlXZpmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHXlOodKSzVyPUO3MlI4OjlizszN MWnTRW5ITVJ?
BALL-1 NGrjNGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{P0e2lEPTB;M{euOVMyPiEQvF2= NWLSenpLW0GQR1XS
BE-13 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIXiRYdKSzVyPUO3MlcxOThizszN MnvDV2FPT0WU
COLO-678 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYDrNphzUUN3ME2zO{46PDN5IN88US=> NIfDZoxUSU6JRWK=
SK-MEL-3 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTN6LkKzPVch|ryP M{nET3NCVkeHUh?=
OAW-28 NGGxdJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU\JR|UxRTN6Lk[zPUDPxE1? M{TZN3NCVkeHUh?=
CAMA-1 M2\QdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTN6Lkm2PVEh|ryP NYTBSnZGW0GQR1XS
C2BBe1 NUHpdmxjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTN7LkixPEDPxE1? M3u0WnNCVkeHUh?=
A3-KAW NIXEN2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M122RWlEPTB;NECuN|Y3OSEQvF2= MWHTRW5ITVJ?
SK-MEL-24 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYLsfmNRUUN3ME20NE42QTNzIN88US=> MoDUV2FPT0WU
KYSE-140 MmPFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlq3TWM2OD12MD63NVY2KM7:TR?= MoT0V2FPT0WU
MOLT-16 M3e1Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3zDRWlEPTB;NEGuNVU{PiEQvF2= NYjWc4xbW0GQR1XS
CFPAC-1 NFfmXIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MknTTWM2OD12Mj61NlEyKM7:TR?= MkHtV2FPT0WU
NB14 NF3jeJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV\IWm11UUN3ME20Nk44ODJ5IN88US=> MnnpV2FPT0WU
COLO-792 NF7pcm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGHiU41KSzVyPUSyMlg6PjFizszN NGTOZlRUSU6JRWK=
RH-1 NVj3[FBQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHn0VoxKSzVyPUSzMlQ5OzZizszN M4WxOHNCVkeHUh?=
NCI-H522 NHTldHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYrPeYx3UUN3ME20OE4{PTZ6IN88US=> M1z1SHNCVkeHUh?=
Ca-Ski MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1jiZ2lEPTB;NESuPFEyPCEQvF2= NYTTV5dqW0GQR1XS
KGN MmO1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGnq[YVKSzVyPUS4MlMxPjNizszN NX;KfVQ4W0GQR1XS
UACC-62 NYXpe|dyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3rEUmlEPTB;NEiuOFA4OiEQvF2= MVLTRW5ITVJ?
NCI-H358 NXfabmc3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYDpO4dPUUN3ME20PU4{ODF6IN88US=> NYX1O2tFW0GQR1XS
LS-411N MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmjYTWM2OD12OT6zNVE5KM7:TR?= M4XiPXNCVkeHUh?=
IST-MES1 MknOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTR7LkW2NlUh|ryP NIP4cWtUSU6JRWK=

... Click to View More Cell Line Experimental Data

In vivo Administration of GDC-0941 at 75 mg/kg/day displays significant inhibitory effect against established human U87MG glioblastoma xenografts in female NCr athymic mice, with tumor growth inhibition of 83%. [1] Oral administration of GDC-0941 at 150 mg/kg/day inhibits the growth of HER2-amplified, trastuzumab-resistant MDA-MB-361.1 xenografts in mice, and significantly delays the tumor progression, in association with potent induced apoptosis in tumors. [2] GDC-0941 (75 mg/kg/day) treatment for 2 weeks induces ~40% reduction in tumor volume of spontaneous B-cell follicular lymphomas developed in PTEN+/-LKB1+/hypo mice, accompanied by ablation of phosphorylation of Akt, S6K and SGK (serum and glucocorticoid protein kinase) protein kinases. [4]

Protocol

Kinase Assay:[1]
+ Expand

Scintillation proximity assay:

Recombinant human PI3Kα, PI3Kβ, and PI3Kδ are coexpressed in a Sf9 baculovirus system with the p85α regulatory subunit and purified as GST-fusion proteins using affinity chromatography on glutathione-sepharose. Recombinant human PI3Kγ is expressed as monomeric GST-fusions and purified similarly. GDC-0941 is dissolved in DMSO and added to 20 mM Tris-HCl (pH 7.5) containing 200 μg yttrium silicate (Ysi) polylysine SPA beads, 4 mM MgCl2, 1 mM dithiothreitol (DTT), 1 μM ATP, 0.125 μCi [γ-33P]-ATP, and 4% (v/v) DMSO in a total volume of 50 μL. The recombinant GST-fusion of PI3Kα (5 ng), PI3Kβ (5 ng), PI3Kδ (5 ng), or PI3Kγ (5 ng) is added to the assay mixture to initiate the kinase reaction. After incubation for 1 hour at room temperature, the kinase reaction is terminated with 150 μL PBS. The mixture is then centrifuged for 2 minutes at 2000 rpm and read using a Wallac Microbeta counter. The reported IC50 values are calculated using a sigmoidal, dose-response curve fit in MDL Assay Explorer.
Cell Research:[2]
+ Expand
  • Cell lines: SKBR-3, BT474-M1, AU-565, HCC-1419, ZR75-30, KPL-4, JIMT-1, BT474-EEI, HCC-1954, MCF-7, CALU-3, SKOV-3, and MKN-7 cells
  • Concentrations: Dissolved in DMSO, final concentrations ~10 μM
  • Incubation Time: 48 and 72 hours
  • Method: Cells are exposed to various concentrations of GDC-0941 for 48, and 72 hours. Proliferation/viability of cells is detected by using the CellTiter-Glo Luminescent Cell Viability Assay. The pAkt (Ser473), cleaved caspase-3, and cleaved PARP are analyzed by western blot. The Caspase-Glo 3/7 assay and the Cell Death Detection ELISAplus assay are used to detect caspase 3/7 activity, and apoptosis, respectively.
    (Only for Reference)
Animal Research:[2]
+ Expand
  • Animal Models: NCR nude mice implanted with MDA-MB-361.1 cells, and SCID, C.B-17/IcrHsd-Prkdcscid mice implanted subcutaneously with BT474-M1 cells
  • Formulation: Dissolved in 10% DMSO, 5% Tween 20, 85% water
  • Dosages: ~150 mg/kg/day
  • Administration: Oral gavage
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 44 mg/mL (85.66 mM)
Water <1 mg/mL
Ethanol <1 mg/mL
In vivo 2% DMSO+30% PEG 300+5% Tween 80+ddH2O 5mg/mL

* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 513.64
Formula

C23H27N7O3S2

CAS No. 957054-30-7
Storage powder
in solvent
Synonyms RG7321

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00999128 Completed Healthy Volunteers Genentech, Inc. October 26, 2009 Phase 1
NCT02092831 Completed Healthy Volunteer Genentech, Inc. April 2014 Phase 1
NCT01740336 Active, not recruiting Breast Cancer Genentech, Inc. February 2013 Phase 2
NCT01493843 Completed Non-Squamous Non-Small Cell Lung Cancer Genentech, Inc. January 2012 Phase 2
NCT01474668 Completed Healthy Volunteer Genentech, Inc. October 2011 Phase 1
NCT01437566 Completed Breast Cancer Genentech, Inc. October 2011 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID