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CAY10505

Catalog No.S2682 1 Review(s)
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CAY10505 Chemical Structure

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Biological Activity

CAY10505 is a potent PI3Kγ inhibitor with an IC50 of 30 nM. Phosphoinositide 3-kinase γ (PI3Kγ) is expressed primarily in hematopoietic cells and plays several important roles in immunity. CAY10505  also prevents other α, β, and δ isoforms with IC50 of 0.94, 20, and 20 μM, respectively. CAY10505  significantly inhibits only the unrelated casein kinase 2 (CK2, IC50 = 20 nM). CAY10505  also suppress the phosphorylation of the PI3K substrate PKB/Akt in murine macrophages (IC50 = 228 nM). Oral administration of CAY10505  decreases neutrophil recruitment in mice to an extent that is comparable to that observed in PI3Kγ-deficient mice. [1]

References on CAY10505
  • [1] J Med Chem 2006 Jun 29;49(13):3857-71
Molecular Weight (WM): 289.28
Formula:

C14H8FNO3S

CAS No.: 1218777-13-9
Synonyms:
N/A
Dissolve in (25°C): DMSO ≥58mg/mL 
Water <1mg/mL 
Ethanol <1mg/mL 
Storage: 2 years-20°CPowder
1 week-4°Cin DMSO
1 month-80°in DMSO

Quality Control & MSDS

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COA H-NMR HPLC

Research Area

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    After starved in serum-free medium for 24h,A549 cells incubated with the indicated concentrations of CAY10505 for 3h,followed by 20-minute stimolation of 100ng/ml EGF.

  • After starved in serum-free medium for 24h,A549 cells incubated with the indicated concentrations of CAY10505 for 3h,followed by 20-minute stimolation of 100ng/ml EGF.

  • Data independently produced by Dr. Zhang of Tianjin Medical University
    CAY10505 purchased from Selleck

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After starved in serum-free medium for 24h,A549 cells incubated with the indicated concentrations of CAY10505 for 3h,followed by 20-minute stimolation of 100ng/ml EGF.

Data independently produced by Dr. Zhang of Tianjin Medical University

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