Research Area
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AZD6482 Chemical Structure
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Biological Activity
AZD6482 is a PI3Kβ inhibitor (IC50=0.021μM) used in antithrombotic therapy. This agent targets a process that is critical to pathological thrombus formation without interfering with normal haemostasis, which avoids the drawbacks of the existing anti-thrombotic therapy. This agent inhibits PI3Kβ/α/γ/δwith IC50 of 0.021, 1.4, 1.2, 0.08μM, respectively. It washed platelet aggregation with concentration at 6 nM.
Chemical Information
| Molecular Weight (WM): | 408.45 |
|---|---|
| Formula: | C22H24N4O4 |
| CAS No.: | 1173900-33-8 |
| Synonyms: |
N/A
|
| Dissolve in (25°C): | DMSO ≥82mg/mL |
| Water <1mg/mL | |
| Ethanol ≥28mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
Quality Control & MSDS
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After starved in serum-free medium for 24h,A549 cells incubated with the indicated concentrations of AZD6482 for 3h,followed by 20-minute stimolation of 100ng/ml EGF.
After starved in serum-free medium for 24h,A549 cells incubated with the indicated concentrations of AZD6482 for 3h,followed by 20-minute stimolation of 100ng/ml EGF.
Data independently produced by Dr. Zhang of Tianjin Medical University AZD6482 purchased from Selleck
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After starved in serum-free medium for 24h,A549 cells incubated with the indicated concentrations of AZD6482 for 3h,followed by 20-minute stimolation of 100ng/ml EGF. |
Data independently produced by Dr. Zhang of Tianjin Medical University
We give free samples and rewards to people who would like to provide us useful scientific data(western blot, etc.) > See Details
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