TLR

  • Inhibitory Selectivity
  • Solubility
Catalog No. Product Name Solubility(25°C)
Water DMSO Alcohol
S7221 GS-9620 <1 mg/mL 1 mg/mL <1 mg/mL
S8562 CA-4948 <1 mg/mL 30 mg/mL <1 mg/mL
S8133 Resiquimod <1 mg/mL 63 mg/mL 21 mg/mL
S7161 Motolimod (VTX-2337) <1 mg/mL 55 mg/mL 15 mg/mL
S8663 Takinib <1 mg/mL 64 mg/mL <1 mg/mL
Catalog No. Information Product Use Citations Product Validations
S7221

GS-9620

GS-9620 is a potent and selective orally active small molecule agonist of Toll-like receptor 7.

S8562New

CA-4948

CA-4948 is a reversible kinase inhibitor that modulates IRAK4 function in both the toll-like receptor (TLR) and interleukin 1 receptor (IL-1R) signaling cascades, and demonstrates pharmacodynamic and antitumor activity in in vitro and in vivo nonclinical models.

S8133

Resiquimod

Resiquimod is an immune response modifier that acts as a potent TLR 7/8 agonist. Phase 2.

S7161

Motolimod (VTX-2337)

Motolimod (VTX-2337) is a selective and potent Toll-like receptor (TLR) 8 agonist with EC50 of 100 nM, > 50-fold selectivity over TLR7. Phase 2.

S8663New

Takinib

Takinib is a potent and selective TAK1 inhibitor with an IC50 of 9.5 nM, more than 1.5 log more potent than the second and third ranked targets, IRAK4 (120 nM) and IRAK1 (390 nM), respectively.