TNF-alpha

Signaling Pathway Map

Research Area

  • Inhibitory Selectivity
  • Solubility
Catalog No. Product Name Solubility(25°C)
Water DMSO Alcohol
S1567 Pomalidomide <1 mg/mL 54 mg/mL <1 mg/mL
S1193 Thalidomide <1 mg/mL 51 mg/mL 2 mg/mL
S8037 Necrostatin-1 <1 mg/mL 51 mg/mL <1 mg/mL
S4902 QNZ (EVP4593) <1 mg/mL 5 mg/mL <1 mg/mL
S1623 Acetylcysteine 33 mg/mL 33 mg/mL 33 mg/mL
S8484 GSK2982772 <1 mg/mL 75 mg/mL 30 mg/mL
S7609 GW4869 <1 mg/mL <1 mg/mL <1 mg/mL
S7942 Bioymifi <1 mg/mL 43 mg/mL <1 mg/mL
S4238 Cepharanthine <1 mg/mL 100 mg/mL <1 mg/mL
S8169 GSK481 <1 mg/mL 75 mg/mL <1 mg/mL

Isoform-specific Inhibitors

Catalog No. Information Product Use Citations Product Validations
S1567

Pomalidomide

Pomalidomide inhibits LPS-induced TNF-α release with IC50 of 13 nM in PBMCs.

S1193

Thalidomide

Thalidomide was introduced as a sedative drug, immunomodulatory agent and also is investigated for treating symptoms of many cancers. Thalidomide inhibits an E3 ubiquitin ligase, which is a CRBN-DDB1-Cul4A complex.

S8037

Necrostatin-1

Necrostatin-1 is a specific RIP1 inhibitor and inhibits TNF-α-induced necroptosis with EC50 of 490 nM in 293T cells.

S4902

QNZ (EVP4593)

QNZ (EVP4593) shows potent inhibitory activity toward both NF-κB activation and TNF-α production with IC50 of 11 nM and 7 nM in Jurkat T cells, respectively.

S1623

Acetylcysteine

Acetylcysteine(N-acetyl-l-cysteine) is a ROS(reactive oxygen species) inhibitor that antagonizes the activity of proteasome inhibitors. It is also a tumor necrosis factor production inhibitor, used mainly as a mucolytic, protects against acetaminophen overdose-induced hepatotoxicity by maintaining or restoring hepatic concentrations of glutathione.

A2010New

Adalimumab

Adalimumab is the first fully human, recombinant IgG1 monoclonal antibody that specifically targets human TNF-alpha, MW: 144.19 KD.

S8484New

GSK2982772

GSK2982772 is an ATP competitive receptor-interacting protein-1 (RIP1) kinase inhibitor with the IC50 value of 1 nM. It has exquisite kinase specificity and excellent activity in blocking many TNF-dependent cellular responses.

S7609New

GW4869

GW4869 is a neutral, noncompetitive inhibitor of sphingomyelinase (SMase) with an IC50 of 1 μM. It is selective for N-SMase, and does not inhibit acid SMase at up to at least 150 μM.

S7942New

Bioymifi

Bioymifi, a small-molecule death receptor 5 (DR5) agonist, binds to the extracellular domain(ECD) of DR5 with a Kd of 1.2 μM but showed little binding affinity to the DR4 ECD. It induces DR5 clustering and aggregation, leading to apoptosis.

S4238

Cepharanthine

Cepharanthine is a biscoclaurine alkaloid inhibiting tumor necrosis factor (TNF)-α-mediated NFκB stimulation, plasma membrane lipid peroxidation and platelet aggregation and suppressing cytokine production.

S8169

GSK481

GSK481 is a RIP1(Receptor Interacting Protein Kinase1) inhibitor. Inhibition of RIP1 has been shown to hinder cell necrotic death.