TNF-alpha

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TNF-alpha Inhibitors (4)

water-soluble

Cat.No. Product Name Information Product Use Citation Customer Product Validation
S1567 Pomalidomide Pomalidomide inhibits LPS-induced TNF-α release with IC50 of 13 nM in PBMCs.
  • Blood, 2011, 118(18):4771-9
  • Br J Haematol, 2014, 166(4):529-39
  • J Virol, 2012, 86(17):9351-60
S1193 Thalidomide Thalidomide was introduced as a sedative drug, immunomodulatory agent and also is investigated for treating symptoms of many cancers. Thalidomide inhibits an E3 ubiquitin ligase, which is a CRBN-DDB1-Cul4A complex.
  • FASEB J, 2015, 29(12):4829-39
S8037 Necrostatin-1 Necrostatin-1 is a specific RIP1 inhibitor and inhibits TNF-α-induced necroptosis with EC50 of 490 nM in 293T cells.
  • Cancer Res, 2015, 10.1158/0008-5472.CAN-14-2199
  • Cancer Res, 2016, 10.1158/0008-5472.CAN-16-0523
  • Free Radical Biology and Medicine, 2016, S0891-5849(16)00114-3
S4902 QNZ (EVP4593) QNZ (EVP4593) shows potent inhibitory activity toward both NF-κB activation and TNF-α production with IC50 of 11 nM and 7 nM in Jurkat T cells, respectively.
  • Nephrol Dial Transplant, 2016, pii: gfw058

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Cat.No. Product Name Solubility (25°C)
Water DMSO Ethanol
S1567 Pomalidomide <1 mg/mL 55 mg/mL <1 mg/mL
S1193 Thalidomide <1 mg/mL 52 mg/mL 2 mg/mL
S8037 Necrostatin-1 <1 mg/mL 51 mg/mL <1 mg/mL
S4902 QNZ (EVP4593) <1 mg/mL 5 mg/mL <1 mg/mL
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