| S5816 |
Pyrvinium pamoate
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Pyrvinium pamoate(Pyrvinium embonate) is an anthelmintic effective for pinworms.
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Infect Drug Resist, 2025, 18:783-789
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Endocrine, 2024, 10.1007/s12020-024-03887-0
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Adv Healthc Mater, 2023, e2300591.
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| S4610 |
Mebendazole
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Mebendazole is a synthetic benzimidazole derivate and anthelmintic agent. This compound interferes with the reproduction and survival of helminths by inhibiting the formation of their cytoplasmic microtubules, thereby selectively and irreversibly blocking glucose uptake.
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Cancers (Basel), 2022, 14(17)4196
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Molecules, 2022, 8127
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Molecules, 2022, 27(23)8127
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| S4104 |
Diminazene Aceturate
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Diminazene(Diminazene diaceturate) is a di-amidine also known as 4,4-(1-Triazene–1,3–diyl)bis(benzenecarboximidamide), used as an effective trypanocidal agent. The main biochemical mechanism of the trypanocidal actions of Diminazene aceturate is by binding to trypanosomal kinetoplast DNA (kDNA) in a non-intercalative manner through specific interaction with sites rich in adenine-thymine base pairs. Diminazene aceturate is also an angiotensin-converting enzyme 2 (ACE2) activator and has strong and potent anti-inflammatory properties.
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Sci Rep, 2025, 15(1):18633
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Scientific Reports, 2025, 18633
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Cell, 2024, 187(15):4095-4112.e21
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| S4068 |
Tinidazole
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Tinidazole (CP12574) is an anti-parasitic drug.
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Cancer Res Commun, 2025, 10.1158/2767-9764.CRC-24-0433
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International Journal of Molecular Sciences, 2024, 4413
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Int J Mol Sci, 2024, 25(8)4413
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| S5948 |
Amodiaquine
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Amodiaquine is a synthetic aminoquinoline that acts by binding to the protozoal or parasitic DNA and preventing DNA and RNA production and subsequent protein synthesis. It is used for the therapy of malaria.
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Cell Death Discov, 2024, 10(1):434
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Molecules, 2024, 29(6)1363
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Nat Biomed Eng, 2021, 10.1038/s41551-021-00718-9
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| S1851 |
Oxibendazole
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Oxibendazole is a benzimidazole drug that interferes with metabolic pathways, used to protect against roundworms, strongyles, threadworms, pinworms and lungworm infestations in horses and some domestic pets.
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J Control Release, 2025, 380:417-432
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Oncology Letters, 2018, 2218-2226
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Oncol Lett, 2018, 15(2):2218-2226
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| S1691 |
Praziquantel
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Praziquantel is an anthelmintic effective against flatworms.
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Communications Medicine, 2025, 420
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Parasitology, 2020, 1-11
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PLoS Negl Trop Dis, 2015, 9(3):e0003593
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| S1830 |
Oxfendazole
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Oxfendazole (RS-8858,Fenbendazole sulfoxide) is a broad spectrum benzimidazole anthelmintic.
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Nature Cell Biology, 2019, 203-213
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Mol Med Rep, 2019, 19(4):2921-2926
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Molecular Medicine Reports, 2019, 2921-2926
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| S0467 |
Emodepside
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Emodepside (QHT06, BAY 44-4400, PF 1022-221), a semisynthetic derivative of PF1022A, is a cyclooctadepsipeptide with broad-spectrum anthelmintic activity. This compound activates Ca-dependent SLO-1-like K channels.
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American Journal of Veterinary Research, 2025, 1-6
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American Journal of Veterinary Research, 2025, 1-6
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Am J Vet Res, 2025, 1-6.
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| S3741 |
Benznidazole
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Benznidazole (Radanil) is a nitroimidazole derivative having an antiprotozoal activity by interfering with parasite protein biosynthesis, influencing cytokines production and stimulating host phagocytosis.
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Int J Mol Sci, 2024, 25(8)4413
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Microorganisms, 2022, 10(7)1421
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