| S4592 |
SBE-β-CD
|
SBE-β-CD is a novel, chemically modified cyclodextrin with a structure designed to optimize the solubility and stability of drugs.
|
-
Autophagy, 2025, 21(8):1824-1842
-
Int J Mol Sci, 2025, 26(2)490
-
Front Pharmacol, 2025, 16:1625798
|
|
| S5001 |
CP-690550 (Tofacitinib) Citrate
|
Tofacitinib citrate (CP-690550, Tasocitinib) is a novel JAK inhibitor with IC50 of 1 nM, 20 nM and 112 nM against JAK3, JAK2, and JAK1, respectively. It also has anti-infection activity.
|
-
Cells, 2025, 14(2)102
-
Front Pharmacol, 2025, 16:1549183
-
J Exp Clin Cancer Res, 2024, 43(1):64
|
|
| S7465 |
FTI 277 HCl
|
FTI 277 HCl is a potent and selective farnesyltransferase (FTase) inhibitor with IC50 of 500 pM, about 100-fold selectivity over the closely related GGTase I. This compound inhibits cell growth and induces apoptosis. This chemical is effective in clearing HDV viremia.
|
-
EMBO J, 2025, 44(4):1185-1219
-
BMC Biol, 2025, 23(1):233
-
PLoS One, 2025, 20(9):e0331440
|
|
| S4430 |
HCQ (Hydroxychloroquine) Sulfate
|
Hydroxychloroquine (HCQ) Sulfate is an antimalarial agent used for the treatment of systemic lupus erythematosus, rheumatoid arthritis and other autoimmune, inflammatory and dermatologic conditions. Also acts as an inhibitor of autophagy and toll-like receptor (TLR) 7/9.
|
-
EMBO J, 2025, 10.1038/s44318-025-00581-3
-
iScience, 2025, 28(4):112054
-
Int J Mol Sci, 2025, 26(2)588
|
|
| S2271 |
Berberine chloride
|
Berberine chloride is a quaternary ammonium salt from the group of isoquinoline alkaloids. This compound activates caspase 3 and caspase 8, cleavage of poly ADP-ribose polymerase (PARP) and the release of cytochrome c. It decreases the expression of c-IAP1, Bcl-2 and Bcl-XL. This chemical induces apoptosis with sustained phosphorylation of JNK and p38 MAPK, as well as generation of the ROS. It is a dual topoisomerase I and II inhibitor. It is also a potential autophagy modulator.
|
-
J Cardiovasc Dev Dis, 2025, 12(7)278
-
Adv Healthc Mater, 2023, e2300591.
-
Transl Oncol, 2023, 35:101712
|
|
| S2613 |
Clorsulon
|
Clorsulon (MK-401,L631529) is used in the treatment of Fasciola hepatica infections in calves and sheep.
|
-
iScience, 2024, 27(10):110862
-
J Pers Med, 2022, 12(2)258
-
Hum Cell, 2022, 10.1007/s13577-022-00671-y
|
|
| S4147 |
Azithromycin Dihydrate
|
Azithromycin Dihydrate(CP-62993 dihydrate) is an acid stable orally administered macrolide antimicrobial drug, structurally related to erythromycin.
|
-
J Cell Biochem, 2022, 10.1002/jcb.30213
-
Adv Ther (Weinh), 2020, 2000034
-
PLoS Comput Biol, 2020, 16(12):e1008489
|
|
| S7896 |
Sodium Tauroursodeoxycholate (TUDC)
|
Sodium Tauroursodeoxycholate (TUDC) is a water soluble bile salt, used for the treatment of gallstones and liver cirrhosis.
|
-
iScience, 2024, 27(8):110598
-
Infect Immun, 2024, 92(8):e0030024
-
Microbiome, 2019, 7(1):145
|
|
| S4237 |
Primaquine Diphosphate
|
Primaquine Diphosphate is a transmission-blocking anti-malarial clinically available, displaying a marked activity against gametocytes of all species of human malaria.
|
-
J Extracell Vesicles, 2024, 13(7):e12494
-
bioRxiv, 2024, 2024.10.28.620521
-
Front Pharmacol, 2021, 12:695009
|
|
| S4420 |
Mefloquine HCl
|
Mefloquine HCl(Mefloquin hydrochloride) is a blood schizonticide by inhibiting hemozoin formation, used as an antimalarial drug.
|
-
Mol Med Rep, 2021, 23(1)40
-
bioRxiv, 2020, 2020/9/20.4.7.30734
-
Int J Parasitol Drugs Drug Resist, 2018, 8(2):331-340
|
|