CXCR
Sigaling Pathway Map
Research Area
- Inhibitory Selectivity
- Solubility
| Catalog No. | Product Name | Solubility(25°C) | ||
|---|---|---|---|---|
| Water | DMSO | Alcohol | ||
| S3013 | Plerixafor 8HCl (AMD3100 8HCl) | 100 mg/mL | <1 mg/mL | <1 mg/mL |
| S8030 | Plerixafor (AMD3100) | 3 mg/mL | <1 mg/mL | 100 mg/mL |
| S2912 | WZ811 | <1 mg/mL | 30 mg/mL | <1 mg/mL |
| S2879 | AMD3465 hexahydrobromide | 98 mg/mL | 2 mg/mL | <1 mg/mL |
| S7651 | SB225002 | <1 mg/mL | 70 mg/mL | 3 mg/mL |
| S8309 | ATI-2341 | <1 mg/mL | 100 mg/mL | 2 mg/mL |
Isoform-specific Inhibitors
- CXCR Antagonists (5)
- CXCR Agonists (1)
- New CXCR Products
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S8309New |
ATI-2341ATI-2341, pepducin targeting the C-X-C chemokine receptor type 4 (CXCR4), is an allosteric agonist activating the inhibitory heterotrimeric G protein (Gi) to promote inhibition of cAMP production and induce calcium mobilization. |
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| S3013 |
Plerixafor 8HCl (AMD3100 8HCl)Plerixafor 8HCl (AMD3100 8HCl) is the hydrochloride of Plerixafor, a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM in cell-free assays, respectively. |
Chemotaxis (Transwell invasion) assay showing the migration of BMSCs in response to CXCL12 (0–100 ng/ml) and the inhibitory effect of the CXCR4 antagonist AMD3100 (5 mg/ml, 30 min). *P < 0.05, compared with the control group (no treatment); #P < 0.05; n = 4 wells from separate cultures.
|
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| S8030 |
Plerixafor (AMD3100)Plerixafor (AMD3100) is a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM in cell-free assays, respectively. |
Chemotaxis (Transwell invasion) assay showing the migration of BMSCs in response to CXCL12 (0–100 ng/ml) and the inhibitory effect of the CXCR4 antagonist AMD3100 (5 mg/ml, 30 min). *P < 0.05, compared with the control group (no treatment); #P < 0.05; n = 4 wells from separate cultures.
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|
| S2912 |
WZ811WZ811 is a highly potent competitive CXCR4 antagonist with EC50 of 0.3 nM. |
a. Gelatin degradation by NCI-H460/R and COR-L23 cells treated with DOX, PF-573228, WZ811 and their combinations for 24 h. Images were captured using a 20× objective on a fluorescence microscope and representative examples are presented on the left part of the panel. At least 100 cells were analyzed per experiment. All experiments were performed at least three times. Merged channels show fluorescent gelatin (green), actin (red) and nuclei (blue) staining; dark areas represent spots of degraded gelatin. Scale bar = 100 μm. Corresponding histograms for each cell line are presented in the right part of the panel showing percentages of degraded gelatin areas relative to the cell volume. Each bar represents mean value ± S.E. * indicates p < 0.05 compared to untreated control cells; # indicates p < 0.05 compared to cells treated with PF-573228; $ indicates p < 0.05 compared to cells treated with WZ811.
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| S2879New |
AMD3465 hexahydrobromideAMD3465 is a monomacrocyclic CXCR4 antagonist with IC50 of 0.75 nM. |
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| S7651 |
SB225002SB225002 is a potent, and selective CXCR2 antagonist with IC50 of 22 nM for inhibiting interleukin IL-8 binding to CXCR2, > 150-fold selectivity over the other 7-TMRs tested. |
The inhibitor SB225002 significantly decreased J82-, CXCL2- or MIF-mediated MDSC migration. The bars represent the s.e.m. of three experiments. *P<0.05.
|
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| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S3013 |
Plerixafor 8HCl (AMD3100 8HCl)Plerixafor 8HCl (AMD3100 8HCl) is the hydrochloride of Plerixafor, a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM in cell-free assays, respectively. |
2015, 10.1172/JCI80883 2014, 123(21):3296-304 2015, 10.15252/emmm.201404698 |
Chemotaxis (Transwell invasion) assay showing the migration of BMSCs in response to CXCL12 (0–100 ng/ml) and the inhibitory effect of the CXCR4 antagonist AMD3100 (5 mg/ml, 30 min). *P < 0.05, compared with the control group (no treatment); #P < 0.05; n = 4 wells from separate cultures.
|
| S8030 |
Plerixafor (AMD3100)Plerixafor (AMD3100) is a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM in cell-free assays, respectively. |
2015, 125(8):3226-40 2014, 123(21):3296-304 2015, 10.15252/emmm.201404698 |
Chemotaxis (Transwell invasion) assay showing the migration of BMSCs in response to CXCL12 (0–100 ng/ml) and the inhibitory effect of the CXCR4 antagonist AMD3100 (5 mg/ml, 30 min). *P < 0.05, compared with the control group (no treatment); #P < 0.05; n = 4 wells from separate cultures.
|
| S2912 |
WZ811WZ811 is a highly potent competitive CXCR4 antagonist with EC50 of 0.3 nM. |
2017, 40(1):47-62 2016, 8(9):3812-3821 |
a. Gelatin degradation by NCI-H460/R and COR-L23 cells treated with DOX, PF-573228, WZ811 and their combinations for 24 h. Images were captured using a 20× objective on a fluorescence microscope and representative examples are presented on the left part of the panel. At least 100 cells were analyzed per experiment. All experiments were performed at least three times. Merged channels show fluorescent gelatin (green), actin (red) and nuclei (blue) staining; dark areas represent spots of degraded gelatin. Scale bar = 100 μm. Corresponding histograms for each cell line are presented in the right part of the panel showing percentages of degraded gelatin areas relative to the cell volume. Each bar represents mean value ± S.E. * indicates p < 0.05 compared to untreated control cells; # indicates p < 0.05 compared to cells treated with PF-573228; $ indicates p < 0.05 compared to cells treated with WZ811.
|
| S2879New |
AMD3465 hexahydrobromideAMD3465 is a monomacrocyclic CXCR4 antagonist with IC50 of 0.75 nM. |
||
| S7651 |
SB225002SB225002 is a potent, and selective CXCR2 antagonist with IC50 of 22 nM for inhibiting interleukin IL-8 binding to CXCR2, > 150-fold selectivity over the other 7-TMRs tested. |
2016, 10.1177/1744806916646381 2016, 789:1-8 2017, 10.1111/jcmm.13070 |
The inhibitor SB225002 significantly decreased J82-, CXCL2- or MIF-mediated MDSC migration. The bars represent the s.e.m. of three experiments. *P<0.05.
|
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S8309New |
ATI-2341ATI-2341, pepducin targeting the C-X-C chemokine receptor type 4 (CXCR4), is an allosteric agonist activating the inhibitory heterotrimeric G protein (Gi) to promote inhibition of cAMP production and induce calcium mobilization. |
