IκB/IKK

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IκB/IKK Inhibitors (15)

water-soluble

Cat.No. Product Name Information Product Use Citation Customer Product Validation
S2913 BAY 11-7082 BAY 11-7082 is a NF-κB inhibitor, inhibits TNFα-induced IκBα phosphorylation with IC50 of 10 μM in tumor cells. Also inhibiting components of the ubiquitin system.
  • Int J Cancer, 2014, 135(2):282-94
  • J Biol Chem, 2014, 289(30):21028-21039
  • Cardiovasc Diabetol, 2014, 13:41
S2882 IKK-16 (IKK Inhibitor VII) IKK-16 (IKK Inhibitor VII) is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM in cell-free assays, respectively.
  • Mol Syst Biol, 2015, 11(3):797
  • Oncogene, 2015, 10.1038/onc.2015.472
  • J Immunol, 2016, 197(3):726-35
S2824 TPCA-1 TPCA-1 is an inhibitor of IKK-2 with IC50 of 17.9 nM in a cell-free assay, inhibits NF-κB pathway, exhibits 22-fold selectivity over IKK-1.
  • Oncogene, 2015, 10.1038/onc.2015.472
  • Mol Cancer, 2014, 13:40
  • Exp Mol Med, 2015, 47:e171
S2864 IMD 0354 IMD-0354 is an IKKβ inhibitor and blocks IκBα phosphorylation in NF-κB pathway.
S8078 Bardoxolone Methyl Bardoxolone Methyl is an IKK inhibitor, showing potent proapoptotic and anti-inflammatory activities. Phase 3.
  • Free Radic Biol Med, 2014, 73:260-9
S7691 PS-1145 PS-1145 is a specific IKK inhibitor with IC50 of 88 nM.
S7851 AZD3264 AZD3264 is a novel IKK2 inhibitor.
S1274 BX-795 BX795 is a potent and specific PDK1 inhibitor with IC50 of 6 nM, 140- and 1600-fold more selective for PDK1 than PKA and PKC in cell-free assays, respectively. Meanwhile, in comparison to GSK3β more than 100-fold selectivity observed for PDK1.
  • Proc Natl Acad Sci USA, 2014, 111(49):17438-43
  • FEBS J, 2014, 281(17):3816-27
  • Virology, 2014, 450-451:182-95
S8044 BMS-345541 BMS-345541 is a highly selective inhibitor of the catalytic subunits of IKK-2 and IKK-1 with IC50 of 0.3 μM and 4 μM in cell-free assays, respectively.
  • PLoS One, 2015, 10(4):e0123410
S4907 SC-514 SC-514 is an orally active, ATP-competitive IKK-2 inhibitor with IC50 of 3-12 μM, blocks NF-κB-dependent gene expression, does not inhibit other IKK isoforms or other serine-threonine and tyrosine kinases.
Cat.No. Product Name Information Product Use Citation Customer Product Validation
S1681 Mesalamine Mesalamine is a specific inhibitor of TNFα-induced IKK activity, used to treat inflammatory bowel disease.
S7352 Bay 11-7085 BAY 11-7085 is an irreversible inhibitor of TNFα-induced IκBα phosphorylation with IC50 of 10 μM.
  • Cancer Lett, 2016, 378(2):131-41
  • Oncol Lett, 2016, 12(2):1438-1444
S7697 LY2409881 LY2409881 is a potent and selective IKK2 inhibitor with IC50 of 30 nM, >10-fold selectivity over IKK1 and other common kinases.
S7442 WS6 WS6 is a β cell proliferation inducer via modulation of Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.
S7441 WS3 WS3 is a β cell proliferation inducer via modulation of Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.

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Cat.No. Product Name Solubility (25°C)
Water DMSO Ethanol
S2913 BAY 11-7082 <1 mg/mL 41 mg/mL 10 mg/mL
S2882 IKK-16 (IKK Inhibitor VII) <1 mg/mL 97 mg/mL <1 mg/mL
S2824 TPCA-1 <1 mg/mL 56 mg/mL <1 mg/mL
S2864 IMD 0354 <1 mg/mL 10 mg/mL 77 mg/mL
S8078 Bardoxolone Methyl <1 mg/mL 21 mg/mL <1 mg/mL
S7691 PS-1145 <1 mg/mL 64 mg/mL 2 mg/mL
S7851 AZD3264 <1 mg/mL 88 mg/mL 2 mg/mL
S1274 BX-795 <1 mg/mL 100 mg/mL <1 mg/mL
S8044 BMS-345541 <1 mg/mL 9 mg/mL <1 mg/mL
S4907 SC-514 <1 mg/mL 45 mg/mL <1 mg/mL
S1681 Mesalamine <1 mg/mL 31 mg/mL 31 mg/mL
S7352 Bay 11-7085 <1 mg/mL 50 mg/mL 50 mg/mL
S7697 LY2409881 <1 mg/mL 20 mg/mL <1 mg/mL
S7442 WS6 <1 mg/mL 100 mg/mL 100 mg/mL
S7441 WS3 <1 mg/mL 100 mg/mL 80 mg/mL
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