BAY 11-7082

Catalog No.S2913 Synonyms: BAY 11-7821

BAY 11-7082 Chemical Structure

Molecular Weight(MW): 207.25

BAY 11-7082 is a NF-κB inhibitor, inhibits TNFα-induced IκBα phosphorylation with IC50 of 10 μM in tumor cells. Also inhibiting components of the ubiquitin system.

Size Price Stock Quantity  
In DMSO USD 120 In stock
USD 90 In stock
USD 270 In stock

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3 Customer Reviews

  • Immunofluorescence images of Ishikawa cells showing the increase in the nuclear colocalization of ERa (red) and p65 (green) after E2 incubation. Nuclear colocalization is yellow. Treatment with ICI 182,780, PDTC or Bay inhibited the nuclear localization of both ERa and p65. Blue, DAPI-stained nuclei. All pictures were obtained the same day using the same microscope settings. Original magnification 3200, bar =50 um. Arrows, cytoplasmic ERa and p65 staining. ICI, ICI 182,780; Bay, Bay 11-7082.

    Int J Cancer 2014 135(2), 282-94. BAY 11-7082 purchased from Selleck.

    Shown are Western blot analysis of Wnt5a expression in HDPCs treated with TNF-a (n=3–4). The gene expression level was normalized to GAPDH (n = 3–6). HDPCs were preincubated with pyrrolidinedithiocarbamic acid (PDTC, an NF-κB inhibitor), BAY11-7082 (an NF-κB inhibitor), SP600125 (a JNK inhibitor), SB203580 (a p38 inhibitor), or U0126 (an ERK inhibitor) before treatment with TNF-a.

    J Biol Chem 2014 289(30), 21028-21039. BAY 11-7082 purchased from Selleck.

  • The effect of vaspin on TNF α -induced THP-1 cell adhesion to HAECS measured staining with VibrantDiO® Cell-Labeling Solution. The level of THP-1 cell adhesion to HAECs was measured at 4 hr after treatment with 25 -100 ng/mL vaspin in the presence or absence of 10 ng/mL TNF α . BAY11-7082 (10 uM, S2913, Selleckchem, USA), an inhibitor of NF- κ B, was used as a positive control.

    Cardiovasc Diabetol 2014 13, 41. BAY 11-7082 purchased from Selleck.

Purity & Quality Control

Choose Selective IκB/IKK Inhibitors

Biological Activity

Description BAY 11-7082 is a NF-κB inhibitor, inhibits TNFα-induced IκBα phosphorylation with IC50 of 10 μM in tumor cells. Also inhibiting components of the ubiquitin system.
Targets
E2-conjugating enzymes [6]
(Cell-free assay)
IκBα phosphorylation [1]
(Tumor cells)
10 μM
In vitro

BAY 11-7082 completely and specifically abrogates NF-κB DNA binding, downregulating the NF-κB-inducible cytokine IL-6 and inducing apoptosis. [1] BAY 11-7082 (< 8 μM) is able to effectively inhibit both basal and TNFα stimulated NFκB luciferase activity in a dose dependent manner. BAY 11-7082 (8 μM) strongly inhibits the rate of proliferation in NCI-H1703 cells. [2] Bay 11-7082 (5 μM) rapidly and efficiently reduces the DNA binding of NF-kappaB in HTLV-I-infected T-cell lines and down-regulates the expression of the antiapoptotic gene, Bcl-x(L), whereas it has little effect on the DNA binding of another transcription factor, AP-1. Bay 11-7082-induced apoptosis of primary ATL cells is more prominent than that of normal peripheral blood mononuclear cells, and apoptosis of these cells is also associated with down-regulation of NF-kappaB activity. Bay 11-7082 (5 μM) selectively induces apoptosis of HTLV-I–infected T-cell lines associated with down-regulation of the expression of cyclin D1, cyclin D2, and Bcl-xL. [3] BAY 11-7082 (100 μM) prevents the nuclear translocation of p65 elicited by NMDA and the NMDA-induced increase of NF-κB binding in mouse hippocampal slices. BAY 11-7082 prevents NMDA toxicity occurring in CA1 region of hippocampal slices with 40% neuroprotection at 20 μM and 70% neuroprotection at 100 μM. [4] BAY 11-7082 at all concentrations tested significantly inhibits NF-κB p65 DNA-binding activity in adipose tissue, whereas in skeletal muscle, BAY 11-7082 at 50 μM and 100 μM significantly inhibits NF-κB p65 DNA-binding activity. BAY 11-7082 (100 μM) reduces IKK-β protein in human adipose tissue and skeletal muscle. BAY 11-7082 (100 μM) significantly decreases the release of TNF-α from adipose tissue, whereas the release of IL-6 and IL-8 is significantly inhibited at all concentrations of BAY 11-7082 tested. BAY 11-7082 (50 μM) significantly decreases the release of TNF-α, IL-6, and IL-8 in skeletal muscle. [5] BAY 11-7082 is also found to inactivate the E2-conjugating enzymes Ubc (ubiquitin conjugating) 13 and UbcH7 and the E3 ligase LUBAC (linear ubiquitin assembly complex), and thus induces B-cell lymphoma and leukaemic T-cell death. [6]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HeLa M3n3dWZ2dmO2aX;uJGF{e2G7 M1TndFExyqEQvF2= MmGxNU42KGh? MWrhZo9tcXOqZYOgRnBCKGmwZIXj[YQhfXBicnXneYxifGmxbjDv[kBHViCjbnSgUW1RNToEoB?= M{PDXFI2Pzl5NEO3
SiHa  MYXGeY5kfGmxbjDBd5NigQ>? MlPaNVDDqM7:TR?= M4OxVlEvPSCq M2mxWoFjd2yrc3jld{BDWEFiaX7keYNm\CC3cDDy[Yd2dGG2aX;uJI9nKE[QIHHu[EBOVVBvOdMg MVyyOVc6PzR|Nx?=
ARPE-19 MmHSSpVv[3Srb36gRZN{[Xl? NXvBOJU{OSEQvF2= M4PYUlAvPSCq NWPEPYRke3WycILld5NmeyCWRz3pcoR2[2WmwrDJUE05yqCycn;tc5RmeiCjY4TpeoF1cW:w NWfXeWFYOjV3OUOwNlk>
HCT116 MUjGeY5kfGmxbjDBd5NigQ>? NED1WWM2KM7:TR?= NV3MbW1POiCq NInQNY5FVVOR MYfheJRmdnWjdHXzJJNqdHmvYYLpck1qdmS3Y3XkJIRwf26{ZXf1cIF1cW:wIH;mJIN6[2yrbjDENS=> MYiyOVQ4QTd{Mx?=
HMECs MYHGeY5kfGmxbjDBd5NigQ>? NVvTR5loPcLizszN NEmxSIQzKGh? Mk\kZYJwdGm|aHXzJHRPTi4QsT3pcoR2[2WmIG\DRW0uOSCneIDy[ZN{cW:wwrC= NX3k[mk1OjVzOUOxNVY>
A549  M3fTfmZ2dmO2aX;uJGF{e2G7 NGjy[|UyOOLCidM1US=> MX:xNkBp NUDselBQe3WycILld5NmeyCGdnytN{BqdmS3Y3XkJIFkfGm4YYTpc44hd2ZicE[1 M2TLe|I2OTV4OECw
RAW 264.7 M1zT[2Z2dmO2aX;uJGF{e2G7 MXe1xsDPxE1? MmrWNUBp NF3TfIZqdmirYnn0d{BVVkZvzsGgZY5lKEmOLUGyJJA1OCCycn;keYN1cW:w NXy1fm81OjVyMUm1Olc>
macrophages NVfqT2lETnWwY4Tpc44hSXO|YYm= MWG1JOK2VQ>? MVSzJIg> MkfodIFzfGmjbHz5JIJtd2OtczDZVGZUNWmwZIXj[YQh\XiycnXzd4lwdiCxZjDpUm9UKGGwZDDDU3guOsLi NXywUHhEOjR7Nke4PVg>
HUVECs MU\GeY5kfGmxbjDBd5NigQ>? NFq0[I0{NTNyIN88US=> MlrSNUBp NI\VNVNz\WS3Y3XzJJRp\SCneIDy[ZN{cW:wIH;mJI1qWi1zNE\hJIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnXy NYXuZpdkOjR6NkO5OlU>
HeLa  MlvzSpVv[3Srb36gRZN{[Xl? MkfIOeKh|ryP NXvMNHhyOjRiaB?= NY\iU5E4TE2VTx?= MXHy[YR2[2W|IITo[UBi[3Srdnn0fUBw\iCWTl[t{tEheHKxbX;0[ZLDqA>? MoL4NlQ3PTd5OEO=
A549 NVTqWGJbTnWwY4Tpc44hSXO|YYm= NH31NZQyOCEQvF2= MYKx5qCKcA>? NFK0Xm5qdmirYnn0d{B1cGViaX7jdoVie2Vib3[gdIhwe3Cqbz3J{tpD|rFiaX6gVGEyODNvaX7m[YN1\WRiY4XseJVz\XQEoB?= MUmyOFYyOjR6OB?=
HUVEC M1v0dGZ2dmO2aX;uJGF{e2G7 NELh[5IzOCEEtV2= M4DGRlAvPSCq NF\he29FVVOR NGjTc45xemW4ZX70d{B1cGViaX7keYN1cW:wIH;mJGVCVSCneIDy[ZN{cW:w NIHlb20zPDV3MUKwPS=>
A549RT-eto MXHBdI9xfG:|aYOgRZN{[Xl? MlHRNVDDqM7:TR?= NVH6N2xvOjRiaB?= NHnybVhFVVOR NWrwZWNr[WOlZXzldoF1\XNiRlXSU{1u\WSrYYTl[EBieG:ydH;zbZM> MnXYNlQ2OzVyOEO=
THP-1  NUTCe49ETnWwY4Tpc44hSXO|YYm= MV[wMlEwOcLizszN NF;2T2oxNjViaB?= NFHHbJBi[nKxZ3H0[ZMhXE6ILd8xJJNm[3KndHnvckBieyC5ZXzsJIF{KHSqZTDpcoNz\WG|ZXSgd4VkemW2aX;uJI9nKEmOLU[gZY5lKEmOLUJOti=> M1qzelI1Ozd6NUO2
SKCXCR2  NXHHXFBUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnLVNkDDvU1? NULBN2NFPDhiaB?= NGDXRWtl\WO{ZXHz[ZMh[2WubDDwdo9tcW[ncnH0bY9vKHOrZ37p[olk[W62bIm= NGrFeoQzPDN5Nke0Oy=>
SKCXCR2  MmLTSpVv[3Srb36gRZN{[Xl? NEjOZ2YzKML3TR?= NIDQTmk1QCCq M4TxToJtd2OtczD0bIUhS1iFTEGtbY5lfWOnZDDj[YxtKGmwdnHzbY9v NEfjfnkzPDN5Nke0Oy=>
OVCXCR2 M2HTU2Z2dmO2aX;uJGF{e2G7 MmXUNkDDvU1? MnHxOFghcA>? M33pUIJtd2OtczD0bIUhS1iFTEGtbY5lfWOnZDDj[YxtKGmwdnHzbY9v MkXhNlQ{PzZ5NEe=
DSCs  NUjLVZdSTnWwY4Tpc44hSXO|YYm= MXeyMlUh|ryP M1T5Z|AvPSCq M3fMcZJmfmW{c3XzJJRp\SCnbnjhcoNmdWWwdDDv[kBES0x{L1PDVlIh\XiycnXzd4lwdiCxZjDEV2N{KGmwZIXj[YQh[nliSVytN|M> M{nNN|I1OzR2MkSw
WPs NW\mfIJHTnWwY4Tpc44hSXO|YYm= NYfVZW1bOjVizszN NHf2WYk2KG2rbh?= NFPO[nZ{fXCycnXzd4V{KEGWUDDhcoQhfleIIIPlZ5JmfGmxbh?= M{LTSlI1OzNzMkC3
A549RT-eto MnX6RZBweHSxc3nzJGF{e2G7 NE[0TXQyOMLizszN MnO0NlQhcA>? MUfhZ4NmdGW{YYTld{BHOTRiZYj0doFkfC2vZXTpZZRm\CCjcH;weI9{cXNiY3;tZolv\WRidILlZZRu\W62IIfpeIghTjF2 MUKyOFIzODd{NR?=
A549RT-eto M3j2cWZ2dmO2aX;uJGF{e2G7 M{PuSlExyqEQvF2= M37rT|I1KGh? MVnk[YNz\WG|ZYOgeIhmKGW6cILld5Nqd25ibHX2[Yx{KG:oIF7GMe67SiCjbnSgVE1oeMLi NGLDNlAzPDJ{MEeyOS=>
FaDu NWrTUmhFTnWwY4Tpc44hSXO|YYm= M3exblIhcA>? NHH4fFZqdmirYnn0d{BxPjViZYjwdoV{e2mxbjDhcoQh[myxY3vzJHRPTs7zLXnu[JVk\WRiVGfJV3Qh\XiycnXzd4lwdg>? NXfmfplVOjR{MkC2NlI>
IVD  NYrYWnhnTnWwY4Tpc44hSXO|YYm= NHTvXmwyOMLizszN MVOzJIQ> NGjsVohz\X[ncoPld{BVVkZvzsJihLNu\WSrYYTl[EB{fXCycnXzd4lwdiCxZjD0bIUh\Gm|YzDtZZRzcXhibXHjdo9ud2ynY4Xs[ZMh[WepcnXjZY4h[W6mIHPvcIxi\2WwIFnJ MmTHNlQyPzZ6MEi=
IVD  NISwT2tHfW6ldHnvckBCe3OjeR?= MWmxNOKh|ryP M2\WWlMh\A>? MWrhZpJw\2G2ZYOgWG5HNc7z4pETbY5lfWOnZDD1dE1z\We3bHH0bY9vKG:oIFHERW1VWy12IHHu[EBCTEGPVGOtOeKh NFLseoYzPDF5NkiwPC=>
iNKT M2HBfWZ2dmO2aX;uJGF{e2G7 Mn7YNVAwOTByIN88US=> NGC2dZUxNjViaB?= MlnJbY5pcWKrdIOgeIhmKGmwZIXjeIlwdiCxZjDBNmFTKG2UTlGgZY5lKG:2aHXyJIZi[3Sxch?= NVL1bHBzOjRzMkS0OVM>
PC-3 Mnv3SpVv[3Srb36gRZN{[Xl? NX25TZZ7Oi53L{WvNVAh|ryP NYjTR|hIOC53IHi= MmjDZoxw[2u|IFnHSk1KUS2rbnT1Z4VlKFOWUzDtVm5CKGW6cILld5Nqd28EoB?= NVP1[ZhjOjRyNUW1NlA>
THP-1  NFzM[JdHfW6ldHnvckBCe3OjeR?= NWfkRXRkOTEEoN88US=> NIH6epAyyqCq NXz6U4p{[WKxbHnzbIV{KHSqZTDl[oZm[3Rib3[gdmhUWDJ5IH;uJHNTNUFibWLORS=> NWDDfJN3OjN7M{mzPVg>
A549 M32w[WZ2dmO2aX;uJGF{e2G7 M3q5OVHDqM7:TR?= MX60PEBp MXzlcohidmOnczD0bIUhfXBvcnXneYxifGmxbjDv[kBK|rqEIHHu[EB{fWK|ZYH1[Y51KGSnY4LlZZNmKGmwIFLhfEBmgHC{ZYPzbY9vKGmwZIXj[YQh[nliY3;tZolv\WRic4TpcZVt[XSrb36= NIPx[FIzOzlyMEC4NC=>
A549 MVHBdI9xfG:|aYOgRZN{[Xl? NWS0Om9SOcLizszN M3\k[|Q5KGh? NWnSWXVKemWmdXPld{B1cGViY3XscEBl\WG2aDDpcoR2[2WmIHL5JINwdWKrbnXkJJN1cW23bHH0bY9v MYSyN|kxODB6MB?=
NCI-N87 M2KybWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVe0TINFOTBxMkCvN|Ah|ryP MofwOk8zPCCq M{KwSpN2eHC{ZYPz[ZMh[2WubDD2bYFjcWyrdImgd4lodmmoaXPhcpRtgQ>? NV\5eVhrOjN6NE[1OFU>
AGS NVv4PGNsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3fJOlExNzJyL{OwJO69VQ>? MkOzOk8zPCCq NV;DXoF4e3WycILld5NmeyClZXzsJJZq[WKrbHn0fUB{cWewaX\pZ4FvfGy7 MlzkNlM5PDZ3NEW=
MGC80-3 NUjHbY9[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVu0eGRlOTBxMkCvN|Ah|ryP MXy2M|I1KGh? MWHzeZBxemW|c3XzJINmdGxidnnhZoltcXS7IIPp[45q\mmlYX70cJk> NHr1XWgzOzh2NkW0OS=>
HGC-27  M3fLSWZ2dmO2aX;uJGF{e2G7 MVK3MlUwOTVxM{Cg{txO NYS5OHhvPiCq M1nn[4lv\HWlZYOgeIhmKGSncHjvd5Bpd3K7bHH0bY9vKGGwZDD1dE1z\We3bHH0bY9vKG:oIFpOvmLPuQ>? M4\jWlI{QDR4NUS1
MGC80-3 NYPtRoRuTnWwY4Tpc44hSXO|YYm= M2LMNVcvPS9zNT:zNEDPxE1? NH7VWGg3KGh? NUHGWohCcW6mdXPld{B1cGViZHXwbI9{eGixconsZZRqd25iYX7kJJVxNXKnZ4XsZZRqd25ib3[gTe67Ss7z M2rs[|I{QDR4NUS1
HGC-27  MXrBdI9xfG:|aYOgRZN{[Xl? NGXaZlA4NjVxMUWvN|Ah|ryP NX3yV4UzPiCq MYHpcoR2[2W|IHHwc5B1d3OrczDpckBiKHSrbXWtJIFv\CCmb4PlMYRmeGWwZHXueEBu[W6wZYK= NIrjUG4zOzh2NkW0OS=>
HBE  MV;GeY5kfGmxbjDBd5NigQ>? MUmxNO69VQ>? M2fvN|Np M3nSOYFjd2yrc3jld{B1cGViaX7jdoVie2W|IH;mJGlNNTZiZYjwdoV{e2mxbjDpcoR2[2WmIHL5JGNUTQ>? NXKxclR1OjN6MkSwPFk>
HepG2 M4fJc2Z2dmO2aX;uJGF{e2G7 NH\hTZIxNjNxMT:zJO69VQ>? NXS4eGpnPDhiaB?= Mm\jdoVlfWOnczDJUFYucW6mdXPl[EBRV05zIHX4dJJme3Orb36= M1u2d|I{PzlzOEOz
THP-1 M{nPNGZ2dmO2aX;uJGF{e2G7 NWfUbFNVPSEEtV2= MlfQNUBp NULDRVBOTE2VTx?= NHG4TpBqdmirYnn0d{BOXEJvaX7keYNm\CCQRt86RkBi[3SrdnH0bY9v NX;je41pOjN4M{SyNVg>
THP-1  M1nKVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHv1SGU2KML3TR?= MYK0M|gh\A>? NXvFUIdvTE2VTx?= M1uzZ5Jm\HWlZYOgeIhmKH[rYXLpcIl1gSCxZjDpcpRz[WOnbHz1cIFzyqCPVFK= MlX2NlM3OzR{MUi=
MDM NUXsVo1uT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4fvS|UhyrWP MUW0M|gh\A>? NXmxW3luTE2VTx?= M3zwXZJm\HWlZYOgeIhmKH[rYXLpcIl1gSCxZjDpcpRz[WOnbHz1cIFzyqCPVFK= NYjDR2p{OjN4M{SyNVg>
AM NVXzO2ltT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{\6N|UhyrWP NH7nUGU1NzhiZB?= M3GzZmROW09? MlrRdoVlfWOnczD0bIUhfmmjYnnsbZR6KG:oIHnueJJi[2WubIXsZZLDqE2WQh?= MkHUNlM3OzR{MUi=
RAW 264  Mo\kSpVv[3Srb36gRZN{[Xl? M1G2XFAvOi13INM1US=> MVuzNE83OC97MDDtbY4> MnjDbY5pcWKrdIOgeIhmKHCqb4PwbIF1[XOnIHHjeIl3cXS7IH;mJHBVWDGEwrC= MnGzNlM2Pzh|MEK=
HUVEC MV3GeY5kfGmxbjDBd5NigQ>? MWWxNOKh|ryP NUfFbodZOC53IHi= NHjReY1FVVOR NWfn[IlO[2:3boTldoFkfGW|IITo[UBtd3O|IH;mJHRq\TJibWLORS=> M{nNcVI{PTZ|NkOy
HT29 M4PuWWZ2dmO2aX;uJGF{e2G7 MlrmNVAwOzBxMUCwJO69VQ>? MX[xJIg> MnXWbY5pcWKrdHXzJIJwfGhiVGfFRWsucW6mdXPl[EBxOTByIIDyc4Nme3Orbne= NWK5V4U6OjN3MkexOVQ>
HT29 MU\GeY5kfGmxbjDBd5NigQ>? M2qwWVExNzNyL{GwNEDPxE1? NFfPZokyKGh? NGPLe|BqdmirYnn0d{BVVkZvaX7keYNm\CCyaH;zdIhwenmuYYTpc44h[W6mIHTl[5Ji\GG2aX;uJI9nKEoQulNOtS=> M3;RR|I{PTJ5MUW0
MM.1S M2jQemFxd3C2b4Ppd{BCe3OjeR?= M3LCSlMxKML3TR?= MljZN{Bp M2HlNYlv\HWlZYOgUW0h[2WubDDk[YF1cCCrbo\vcJZmeyCwZXPyc5Nqew>? MV2yN|UzPzF3NB?=
KMS-12-BM MU\BdI9xfG:|aYOgRZN{[Xl? M4nCblMxKML3TR?= MXWzJIg> MUHpcoR2[2W|IF3NJINmdGxiZHXheIghcW64b3z2[ZMhdmWlcn;zbZM> NXjIbFJ1OjN3MkexOVQ>
BAFs NHHa[pZHfW6ldHnvckBCe3OjeR?= M17selAvPS9zwrFOwG0> MnnpNlQhcA>? MUDpcohq[mm2czDUUmbPuS:GRWigbY5lfWOnZDDDXXAyQUFzwrD0doFve2O{aYD0dy=> NE\0R3AzOzR6NUS1Oy=>
SP6.5 NXXTOFBsTnWwY4Tpc44hSXO|YYm= MV61JO69VQ>? MV:yJIg> NEDybHJl\WO{ZXHz[ZPDqHS{YX7zcI9k[XSrb36gc4YheDZ3IHnuJJRp\SCwdXPs[ZV{yqB? M2rVXVI{PDR|MEi2
VUP MVzGeY5kfGmxbjDBd5NigQ>? M2HTblUh|ryP NUS1NVc5OiCq NXPYV5Bv\GWlcnXhd4V{yqC2cnHud4xw[2G2aX;uJI9nKHB4NTDpckB1cGViboXjcIV2e8Li NEX1WpYzOzR2M{C4Oi=>
OCM1 M{jBZWZ2dmO2aX;uJGF{e2G7 NVTxTGZ6PSEQvF2= M{DWZlIhcA>? NFzaPWZl\WO{ZXHz[ZPDqHS{YX7zcI9k[XSrb36gc4YheDZ3IHnuJJRp\SCwdXPs[ZV{yqB? MXmyN|Q1OzB6Nh?=
OM431 M1n0RWZ2dmO2aX;uJGF{e2G7 MWi1JO69VQ>? M4XFNlIhcA>? MVHk[YNz\WG|ZYRCpJRz[W6|bH;jZZRqd25ib3[gdFY2KGmwIITo[UBvfWOuZYXzxsA> MnTNNlM1PDNyOE[=
SP6.5 NWDVfJZpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGnCTYczNjVvMkCg{txO MUWyOEBpyqB? MnXITWM2OD13IN88UUwh\XiqaXLpeJMhe3S{b37nJIFvfGlvcILvcIln\XKjdHn2[UBm\m[nY4TzJIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnXy NITtRWUzOzR2M{C4Oi=>
VUP MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVHLfWluOi53LUKwJO69VQ>? NF\iUIMzPCCqwrC= MVLJR|UxRTVizszNMEBmgGirYnn0d{B{fHKxbnegZY51cS2ycn;sbYZmemG2aY\lJIVn\mWldIOgbY4h[SCmb4PlMYRmeGWwZHXueEBu[W6wZYK= MmSyNlM1PDNyOE[=
OCM1 NGixUnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWLQeGF6Oi53LUKwJO69VQ>? MkL5NlQhcMLi NHvaXmlKSzVyPUWg{txONCCneHjpZol1eyC|dILvcoch[W62aT3wdo9tcW[ncnH0bZZmKGWoZnXjeJMhcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7u[ZI> M17k[VI{PDR|MEi2
OM431 MnLTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUfXb4tuOi53LUKwJO69VQ>? MUKyOEBpyqB? MXHJR|UxRTVizszNMEBmgGirYnn0d{B{fHKxbnegZY51cS2ycn;sbYZmemG2aY\lJIVn\mWldIOgbY4h[SCmb4PlMYRmeGWwZHXueEBu[W6wZYK= NYK1VGZVOjN2NEOwPFY>
SP6.5 NFXlW|lCeG:ydH;zbZMhSXO|YYm= MYO1JO69VQ>? NH[wcIYzPCCqwrC= MXfpcoR2[2W|IHHwc5B1d3Orc9Mg MUeyN|Q1OzB6Nh?=
VUP NYTMbI4{SXCxcITvd4l{KEG|c3H5 M3;yO|Uh|ryP MUGyOEBpyqB? MYXpcoR2[2W|IHHwc5B1d3Orc9Mg M1TFZlI{PDR|MEi2
OCM1 NV;rTndUSXCxcITvd4l{KEG|c3H5 MofuOUDPxE1? NV\XSVhpOjRiaNMg NI\abWpqdmS3Y3XzJIFxd3C2b4Ppd:Kh M2fuWVI{PDR|MEi2
OM431 NIXIUG9CeG:ydH;zbZMhSXO|YYm= NHjKfHo2KM7:TR?= NV\qOpp2OjRiaNMg MVzpcoR2[2W|IHHwc5B1d3Orc9Mg M3;TbFI{PDR|MEi2
SP6.5 NGq4e4lHfW6ldHnvckBCe3OjeR?= NYrjcHFmPSEQvF2= NW\PNG5GOTJiaB?= NYLsOok{emWmdXPld{B1cGVibXnndoF1cW:wwrC= NY\re|RoOjN2NEOwPFY>
VUP NFfubW1HfW6ldHnvckBCe3OjeR?= NYG4NHZ[PSEQvF2= Mm\BNVIhcA>? MVny[YR2[2W|IITo[UBucWe{YYTpc47DqA>? MUmyN|Q1OzB6Nh?=
OCM1 NYrzSlhwTnWwY4Tpc44hSXO|YYm= NXKxdZFoPSEQvF2= NX3FenVHOTJiaB?= NYnhVZNiemWmdXPld{B1cGVibXnndoF1cW:wwrC= MVKyN|Q1OzB6Nh?=
OM431 MmHkSpVv[3Srb36gRZN{[Xl? NE[0Rm82KM7:TR?= MlrtNVIhcA>? NFXjVZFz\WS3Y3XzJJRp\SCvaXfyZZRqd28EoB?= MXqyN|Q1OzB6Nh?=
HBL-1  MoTxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYG2ZWhPO8LizszN Mn21NlQwPDhxN{KgbC=> MWTEUXNQ NEnKO3R{dG:5czDj[YxtKGe{b4f0bEBud2Snc4TsfS=> M4m3NFI{PDRzN{Ow
RAW 264.7 MmXNSpVv[3Srb36gRZN{[Xl? MV6yMVE2KM7:TR?= NGP5dGgyKGh? MYPEUXNQ Mkfwd5VxeHKnc4Pld{B1cGViYXP0bZZifGmxbjDv[kBKU0tiZnHtbYx6KG2nbXLldpM> Mn\5NlM1PDF5M{C=
IL-1R  MVLGeY5kfGmxbjDBd5NigQ>? NVTLPGxGOi1zNTFOwG0> MnHGNUBp M2nrbGROW09? NEjJW|B{fXCycnXzd4V{KHSqZTDhZ5RqfmG2aX;uJI9nKEmNSzDmZY1qdHlibXXtZoVzew>? M2Kwb|I{PDRzN{Ow
RAW 264.7 NH61NHRHfW6ldHnvckBCe3OjeR?= NWDIZ|J5OTVizszN MY[xJIg> NXv2XmdKTE2VTx?= NGDyNnV{fXCycnXzd4V{KHSqZTDhZ5RqfmG2aX;uJI9nKGGwZDDKUms> NXjrOlJuOjN2NEG3N|A>
IL-1R  MXTGeY5kfGmxbjDBd5NigQ>? NX7N[mk4OTVizszN NYftVo9COSCq NI\zTmlFVVOR NHOzXWF{fXCycnXzd4V{KHSqZTDhZ5RqfmG2aX;uJI9nKGGwZDDKUms> NVm4dW1NOjN2NEG3N|A>
U2OS NIXCXnJHfW6ldHnvckBCe3OjeR?= M3f6eFE2KM7:TR?= NXjnd5lpOSCq MVPEUXNQ MUnwdoV3\W62czD0bIUhVFCVLTDvdkBKVC1zLYP0bY12dGG2ZXSg[o9zdWG2aX;uJI9nKEt4Mz3wWYIh[2ijaX7zxsA> NFvx[3UzOzR2MUezNC=>
MT‐1  MWDGeY5kfGmxbjDBd5NigQ>? MmHGPOKhyrWv M{XEW|MhcA>? MWTk[YNz\WG|ZYOgeIhmKGyndnXsd{Bw\iCy4pEQV3RCXDNiYX7kJJDjiJB2RVLQNS=> MXyyN|I4QDR5OR?=
MT‐2  M4HkXWZ2dmO2aX;uJGF{e2G7 MXG4xsDDvW1? NFHVcJg{KGh? NIW5V|Nl\WO{ZXHz[ZMhfGinIHzleoVteyCxZjDw5qCRW1SDVEOgZY5lKHEkgKC0SWJROQ>? MYOyN|I4QDR5OR?=
MT‐1  NYnxVWFFTnWwY4Tpc44hSXO|YYm= M1\uZVjDqML3bR?= MYqzJIg> NUDWT2tX\GWlcnXhd4V{KHSqZTDs[ZZmdHNib3[geIhmKHB4NTDzeYJ2dmm2IH;mJG5H6oDSzsrCxsA> MYKyN|I4QDR5OR?=
MT‐2  NF3LUWJHfW6ldHnvckBCe3OjeR?= NXjPcFVVQMLiwsXt NX7QeWVnOyCq MV;k[YNz\WG|ZYOgeIhmKGyndnXsd{Bw\iC2aHWgdFY2KHO3YoXubZQhd2ZiTldihLDPwkMEoB?= MmTVNlMzPzh2N{m=
MCF-7  NGTYNY1HfW6ldHnvckBCe3OjeR?= NFXVTFczNjVvMUWg{txO MkTiNE42KGh? Mor2SG1UVw>? NXfJXWs1[2G3c3XzJJRp\SCpcnHkeYFtKGyxc4Ogc4Yh[2WubDDh[Ihme2mxbh?= M4PtWVI{ODl|MkK3
HaCaT  NFjGNpJHfW6ldHnvckBCe3OjeR?= MYq1MlDDqM7:TR?= MVyxxsBpyqB? MVTheJRmdnWjdHXzJJRp\SCWQ1;IMYlv\HWlZXSgdJJw\HWldHnvckBw\iCLTD22xsA> Mn\KNlMxPDFzNki=
A549  M{i3RWZ2dmO2aX;uJGF{e2G7 NF3l[GwyKGh? M1LmSYlvcGmkaYTzJGxVSS2rbnT1Z4VlKFOSLVGgcXJPSSCycn;keYN1cW:wwrDzbYdvcW[rY3HueIx6 MUSyN|A{OTJzMx?=
OA chondrocytes  M4\xO2Z2dmO2aX;uJGF{e2G7 NIPEWVkyOCEQvF2= NF3uNpMyKGh? M4DnXoJtd2OtczD0bIUhSUeHLVLTRU1qdmS3Y3XkJIdmdmVxcILveIVqdiCneIDy[ZN{cW:wIH;mJGdTWDd6IH;yJGNQYC1{IDjwQFAvODVr NVTxV5VwOjJ7OEKyNlg>
RAW264.7 M1T5e2Z2dmO2aX;uJGF{e2G7 NGDENWgyPSEQvF2= NXrZeFVZOTVvMUKwJI1qdg>? NUPsPHZl[myxY3vzJJRp\SCycn;keYN1cW:wIH;mJG5QNCCSR1WyMEBidmRiVF7GMe6y NHzz[5QzOjd2NUWyNy=>
RAW264.7 NHPucIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{DiOVUuOzBizszN NXTxTolVOjRiaB?= NWH2dodPcW6qaXLpeJMh[2WubDDndo94fGhiaX6gZUBld3OnLXTldIVv\GWwdDDtZY5v\XJ? M4HrVVIzPzR3NUKz
HBL6 NWHTe4RJSXCxcITvd4l{KEG|c3H5 MUmwMlUwPS9{NTFOwG0> NWjvOId[Pi9{NDDo NIHiTXNl\WO{ZXHz[ZMh[2WubDD2bYFjcWyrdImgZY5lKGynZXHkd{B1dyCjcH;weI9{cXNiaX6gZUBld3OnLXTldIVv\GWwdDDtZY5v\XMEoB?= Mo\QNlIxPzR6MkC=
HT29  NEnB[lZHfW6ldHnvckBCe3OjeR?= NGLpU40yNTFyIN88US=> MV[xNOKhcA>? NGPhPHVqdmO{ZXHz[ZMhUE9vMTDtVm5CKGGwZDDwdo91\WmwIHX4dJJme3Orb36= M2P3XVIyPjJyOU[0
Ca9–22 NIH1T5VCeG:ydH;zbZMhSXO|YYm= M{ewblExyqEQvF5CpC=> NEDlS40yKGh? MUXjc41xdGW2ZXz5JIlvcGmkaYTzJGFNSS2SRGStbY5lfWOnZDDhdI9xfG:|aYO= M{ixSlIyOTN6NEiw
Ca9–22 M4nFVWZ2dmO2aX;uJGF{e2G7 NVrwUIZKOTEEoN88UeKh NETKUIYyKGh? MmHYZ49ueGyndHXsfUBi[nKxZ3H0[ZMhfGinIFHMRU1RTFRvaX7keYNm\CCMTlugZYN1cX[jdHnvci=> NXzDWY9mOjFzM{i0PFA>
A-549 NH;MO4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV[xNOKh|ryPwrC= NFnmWVUzPC92ODDo NULXWmJmcW6qaXLpeJMh[2WubDDndo94fGhiaX6gZUB1cW2nLXTldIVv\GWwdDDtZY5v\XJ? MlvyNlA5PjZyNEO=
AP MUXGeY5kfGmxbjDBd5NigQ>? MnH5OU8yOCEQvF2= M{L5PFQ5KGh? NXf4eoUy\G:5boLl[5Vt[XSnczD0bIUhSkGGIIDyc5RmcW5ibHX2[Ywh[SCmb4PlMYRmeGWwZHXueEBu[W6wZYK= MljWNlA2QTZ4NEW=
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AP NXTBVlFtTnWwY4Tpc44hSXO|YYm= MWqyNEDPxE1? M3\ReFQwQCCq MVvkc5dvemWpdXzheIV{KHSqZTDCRWQheHKxdHXpckBt\X[nbDDhJJRqdWVvZHXw[Y5l\W62IH3hco5meg>? MoGzNlA2QTZ4NEW=
AQ1 NFTJTWpHfW6ldHnvckBCe3OjeR?= Mnr0NlAh|ryP M{W0ZlQwQCCq NGPkUVNld3ewcnXneYxifGW|IITo[UBDSURicILveIVqdiCuZY\lcEBiKHSrbXWt[IVx\W6mZX70JI1idm6nch?= MnfkNlA2QTZ4NEW=
THP-1 MUnGeY5kfGmxbjDBd5NigQ>? Mo\wOeKh|ryPwrC= M1zOdlAvPSCq MWfheJRmdnWjdHXzJJRp\SCOUGOtbY5lfWOnZDDwMWnPwkMQsTDwdo91\WmwIHL5JFczLQ>? NVPqNYF5OjB|MEm3NVg>
K562 NXmxZWM3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVKyMVMxKM7:TR?= M1rReVI1KGh? NYTHTllPUUN3ME24JO69VSyrbnjpZol1eyClZXzsJIdzd3e2aDDpckBiKGSxc3Wt[IVx\W6mZX70JI1idm6nch?= M3G3TlE6PjR4OEC3
Jurket MoLBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGXzbmgzNTNyIN88US=> NVH1TZlXOjRiaB?= NIPnRoNKSzVyPUeuNUDPxE1uIHnubIljcXS|IHPlcIwh\3Kxd4ToJIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnXy NYrhWIxrOTl4NE[4NFc>
U937 NWLZSlZPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYGzPYQ1Oi1|MDFOwG0> M3jtSFI1KGh? MXvJR|UxRTFyLkWg{txONCCrbnjpZol1eyClZXzsJIdzd3e2aDDpckBiKGSxc3Wt[IVx\W6mZX70JI1idm6nch?= NVzScW5nOTl4NE[4NFc>
PBMC MmL1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYDIXXlzOi1|MDFOwG0> MUmyOEBp M1vDeGlEPTB;NECuNkDPxE1uIHnubIljcXS|IHPlcIwh\3Kxd4ToJIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnXy M4iwflE6PjR4OEC3
K562 M1eyWGFxd3C2b4Ppd{BCe3OjeR?= MkXUNk0zOMLizszNxsA> NWS3W4JKOjRiaB?= NHXVdppqdmS3Y3XzJIEh\G:|ZT3k[ZBmdmSnboSgZZBweHSxc3nz MYmxPVY1PjhyNx?=

... Click to View More Cell Line Experimental Data

Protocol

Cell Research:[2]
+ Expand
  • Cell lines: NCI-H1703 cells
  • Concentrations: ~8 μM
  • Incubation Time: 12 hours
  • Method: Cells are transfected with siRNA in 96-well microtiter plates and then cultured for 72 hours in complete NSCLC medium, treated with BAY 11-7082 for 12 hours. Cells are incubated with [3H]thymidine for 3 hours. The cells are collected on filters using an automatic cell harvester and radioactivity on the filters is measured by β-scintillation counting.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 41 mg/mL (197.82 mM)
Ethanol 10 mg/mL (48.25 mM)
Water <1 mg/mL
In vivo 5% DMSO+corn oil 8mg/mL

* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 207.25
Formula

C10H9NO2S

CAS No. 19542-67-7
Storage powder
in solvent
Synonyms BAY 11-7821

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID