BAY 11-7082

Catalog No.S2913 Synonyms: BAY 11-7821

BAY 11-7082 Chemical Structure

Molecular Weight(MW): 207.25

BAY 11-7082 is a NF-κB inhibitor, inhibits TNFα-induced IκBα phosphorylation with IC50 of 10 μM in tumor cells. Also inhibiting components of the ubiquitin system.

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In DMSO USD 120 In stock
USD 90 In stock
USD 270 In stock
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3 Customer Reviews

  • Immunofluorescence images of Ishikawa cells showing the increase in the nuclear colocalization of ERa (red) and p65 (green) after E2 incubation. Nuclear colocalization is yellow. Treatment with ICI 182,780, PDTC or Bay inhibited the nuclear localization of both ERa and p65. Blue, DAPI-stained nuclei. All pictures were obtained the same day using the same microscope settings. Original magnification 3200, bar =50 um. Arrows, cytoplasmic ERa and p65 staining. ICI, ICI 182,780; Bay, Bay 11-7082.

    Int J Cancer 2014 135(2), 282-94. BAY 11-7082 purchased from Selleck.

    Shown are Western blot analysis of Wnt5a expression in HDPCs treated with TNF-a (n=3–4). The gene expression level was normalized to GAPDH (n = 3–6). HDPCs were preincubated with pyrrolidinedithiocarbamic acid (PDTC, an NF-κB inhibitor), BAY11-7082 (an NF-κB inhibitor), SP600125 (a JNK inhibitor), SB203580 (a p38 inhibitor), or U0126 (an ERK inhibitor) before treatment with TNF-a.

    J Biol Chem 2014 289(30), 21028-21039. BAY 11-7082 purchased from Selleck.

  • The effect of vaspin on TNF α -induced THP-1 cell adhesion to HAECS measured staining with VibrantDiO® Cell-Labeling Solution. The level of THP-1 cell adhesion to HAECs was measured at 4 hr after treatment with 25 -100 ng/mL vaspin in the presence or absence of 10 ng/mL TNF α . BAY11-7082 (10 uM, S2913, Selleckchem, USA), an inhibitor of NF- κ B, was used as a positive control.

    Cardiovasc Diabetol 2014 13, 41. BAY 11-7082 purchased from Selleck.

Purity & Quality Control

Choose Selective IκB/IKK Inhibitors

Biological Activity

Description BAY 11-7082 is a NF-κB inhibitor, inhibits TNFα-induced IκBα phosphorylation with IC50 of 10 μM in tumor cells. Also inhibiting components of the ubiquitin system.
Targets
E2-conjugating enzymes [6]
(Cell-free assay)
IκBα phosphorylation [1]
(Tumor cells)
10 μM
In vitro

BAY 11-7082 completely and specifically abrogates NF-κB DNA binding, downregulating the NF-κB-inducible cytokine IL-6 and inducing apoptosis. [1] BAY 11-7082 (< 8 μM) is able to effectively inhibit both basal and TNFα stimulated NFκB luciferase activity in a dose dependent manner. BAY 11-7082 (8 μM) strongly inhibits the rate of proliferation in NCI-H1703 cells. [2] Bay 11-7082 (5 μM) rapidly and efficiently reduces the DNA binding of NF-kappaB in HTLV-I-infected T-cell lines and down-regulates the expression of the antiapoptotic gene, Bcl-x(L), whereas it has little effect on the DNA binding of another transcription factor, AP-1. Bay 11-7082-induced apoptosis of primary ATL cells is more prominent than that of normal peripheral blood mononuclear cells, and apoptosis of these cells is also associated with down-regulation of NF-kappaB activity. Bay 11-7082 (5 μM) selectively induces apoptosis of HTLV-I–infected T-cell lines associated with down-regulation of the expression of cyclin D1, cyclin D2, and Bcl-xL. [3] BAY 11-7082 (100 μM) prevents the nuclear translocation of p65 elicited by NMDA and the NMDA-induced increase of NF-κB binding in mouse hippocampal slices. BAY 11-7082 prevents NMDA toxicity occurring in CA1 region of hippocampal slices with 40% neuroprotection at 20 μM and 70% neuroprotection at 100 μM. [4] BAY 11-7082 at all concentrations tested significantly inhibits NF-κB p65 DNA-binding activity in adipose tissue, whereas in skeletal muscle, BAY 11-7082 at 50 μM and 100 μM significantly inhibits NF-κB p65 DNA-binding activity. BAY 11-7082 (100 μM) reduces IKK-β protein in human adipose tissue and skeletal muscle. BAY 11-7082 (100 μM) significantly decreases the release of TNF-α from adipose tissue, whereas the release of IL-6 and IL-8 is significantly inhibited at all concentrations of BAY 11-7082 tested. BAY 11-7082 (50 μM) significantly decreases the release of TNF-α, IL-6, and IL-8 in skeletal muscle. [5] BAY 11-7082 is also found to inactivate the E2-conjugating enzymes Ubc (ubiquitin conjugating) 13 and UbcH7 and the E3 ligase LUBAC (linear ubiquitin assembly complex), and thus induces B-cell lymphoma and leukaemic T-cell death. [6]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HeLa MXrGeY5kfGmxbjDBd5NigQ>? M2LWWVExyqEQvF2= MojyNU42KGh? NIPsVIRi[m:uaYPo[ZMhSlCDIHnu[JVk\WRidYCgdoVofWyjdHnvckBw\iCITjDhcoQhVU2SLUpCpC=> MXSyOVc6PzR|Nx?=
SiHa  M3K1RWZ2dmO2aX;uJGF{e2G7 NH7GcHQyOMLizszN Mn;pNU42KGh? M3zMWoFjd2yrc3jld{BDWEFiaX7keYNm\CC3cDDy[Yd2dGG2aX;uJI9nKE[QIHHu[EBOVVBvOdMg MX[yOVc6PzR|Nx?=
ARPE-19 MljmSpVv[3Srb36gRZN{[Xl? Mkn6NUDPxE1? MlTMNE42KGh? MkPQd5VxeHKnc4Pld{BVTy2rbnT1Z4VlyqCLTD24xsBxem:vb4TldkBi[3SrdnH0bY9v NWm2c4pDOjV3OUOwNlk>
HCT116 NVfIN5FCTnWwY4Tpc44hSXO|YYm= NX:y[oFJPSEQvF2= MlzSNkBp MmLwSG1UVw>? MkTIZZR1\W63YYTld{B{cWy7bXHybY4ucW6mdXPl[EBld3ewcnXneYxifGmxbjDv[kBkgWOuaX6gSFE> NYq4O2ptOjV2N{m3NlM>
HMECs NUTNNId[TnWwY4Tpc44hSXO|YYm= NFmzXnE2yqEQvF2= M4[4XFIhcA>? M2HFfIFjd2yrc3jld{BVVkZvzsGtbY5lfWOnZDDWR2FONTFiZYjwdoV{e2mxbtMg NYHXUIxiOjVzOUOxNVY>
A549  NYnEXHljTnWwY4Tpc44hSXO|YYm= NFj4OVIyOOLCidM1US=> MofINVIhcA>? MnPPd5VxeHKnc4Pld{BFfmxvMzDpcoR2[2WmIHHjeIl3[XSrb36gc4YheDZ3 MXuyOVE2PjhyMB?=
RAW 264.7 M4TPUWZ2dmO2aX;uJGF{e2G7 NHjGN4E2yqEQvF2= NIT5bpYyKGh? NIT2VZZqdmirYnn0d{BVVkZvzsGgZY5lKEmOLUGyJJA1OCCycn;keYN1cW:w NV33VGVHOjVyMUm1Olc>
macrophages M2\TUGZ2dmO2aX;uJGF{e2G7 M4LQbVUhyrWP NXfodnR4OyCq MYPwZZJ1cWGubImgZoxw[2u|IGnQSnMucW6mdXPl[EBmgHC{ZYPzbY9vKG:oIHnOU3Mh[W6mIFPPXE0zyqB? Mn7VNlQ6Pjd6OUi=
HUVECs Ml;5SpVv[3Srb36gRZN{[Xl? NYTxPZU{Oy1|MDFOwG0> NVO1Z3JOOSCq Ml3ldoVlfWOnczD0bIUh\XiycnXzd4lwdiCxZjDtbXIuOTR4YTDpckBiKGSxc3Wt[IVx\W6mZX70JI1idm6nch?= MW[yOFg3Ozl4NR?=
HeLa  MVXGeY5kfGmxbjDBd5NigQ>? MXm1xsDPxE1? NH3GWVczPCCq MoTISG1UVw>? NVrVZ4dRemWmdXPld{B1cGViYXP0bZZqfHlib3[gWG5HNc7zIIDyc41wfGW{wrC= NVjmZngxOjR4NUe3PFM>
A549 M4jjZWZ2dmO2aX;uJGF{e2G7 M1TVSVExKM7:TR?= MVSx5qCKcA>? MoLPbY5pcWKrdIOgeIhmKGmwY4LlZZNmKG:oIIDoc5NxcG9vSd86Ru6yKGmwIGDBNVA{NWmwZnXjeIVlKGO3bIT1doV{yqB? NGizZVQzPDZzMkS4PC=>
HUVEC NHrPcoxHfW6ldHnvckBCe3OjeR?= MXiyNEDDvU1? NYG0W2VlOC53IHi= M{PRZWROW09? NV\UUJdoeHKndnXueJMhfGinIHnu[JVkfGmxbjDv[kBGSU1iZYjwdoV{e2mxbh?= M2\FclI1PTVzMkC5
A549RT-eto NFHSZVNCeG:ydH;zbZMhSXO|YYm= M3jYNFExyqEQvF2= MmPhNlQhcA>? MofUSG1UVw>? NFjnbpli[2OnbHXyZZRmeyCIRWLPMY1m\GmjdHXkJIFxd3C2b4Ppdy=> NWLvNHRQOjR3M{WwPFM>
THP-1  NWTmWWIzTnWwY4Tpc44hSXO|YYm= M{DWblAvOS9zwrFOwG0> NVzQNlRsOC53IHi= MWLhZpJw\2G2ZYOgWG5HNc7zIIPlZ5JmfGmxbjDhd{B4\WyuIHHzJJRp\SCrbnPy[YF{\WRic3XjdoV1cW:wIH;mJGlNNTZiYX7kJGlNNTIQsh?= MkDwNlQ{Pzh3M{[=
SKCXCR2  MlfKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVeyJOK2VQ>? NF;4do01QCCq NX31bmZz\GWlcnXhd4V{KGOnbHygdJJwdGmoZYLheIlwdiC|aXfubYZq[2GwdHz5 MlLkNlQ{PzZ5NEe=
SKCXCR2  M1vtN2Z2dmO2aX;uJGF{e2G7 M{\5W|IhyrWP MYK0PEBp MnrPZoxw[2u|IITo[UBEYEOOMT3pcoR2[2WmIHPlcIwhcW64YYPpc44> MoLaNlQ{PzZ5NEe=
OVCXCR2 MlPjSpVv[3Srb36gRZN{[Xl? NGnVXoczKML3TR?= MWq0PEBp NV7pepR6[myxY3vzJJRp\SCFWFPMNU1qdmS3Y3XkJINmdGxiaX72ZZNqd25? NHntVpczPDN5Nke0Oy=>
DSCs  MkTxSpVv[3Srb36gRZN{[Xl? NGH3eJAzNjVizszN NGjWXYcxNjViaB?= NYjrNm1[emW4ZYLz[ZMhfGinIHXubIFv[2WvZX70JI9nKEOFTEKvR2NTOiCneIDy[ZN{cW:wIH;mJGRUS3NiaX7keYNm\CCkeTDJUE0{Ow>? MoS4NlQ{PDR{NEC=
WPs NHvPUIhHfW6ldHnvckBCe3OjeR?= NEix[mQzPSEQvF2= NHzRVXU2KG2rbh?= NEPRXWZ{fXCycnXzd4V{KEGWUDDhcoQhfleIIIPlZ5JmfGmxbh?= M3nMNlI1OzNzMkC3
A549RT-eto MWfBdI9xfG:|aYOgRZN{[Xl? M{TrfFExyqEQvF2= NWjHTpBROjRiaB?= NWT1N|JE[WOlZXzldoF1\XNiRkG0JIV5fHKjY4StcYVlcWG2ZXSgZZBweHSxc3nzJINwdWKrbnXkJJRz\WG2bXXueEB4cXSqIF[xOC=> MmnQNlQzOjB5MkW=
A549RT-eto NXHUOYlyTnWwY4Tpc44hSXO|YYm= Moj5NVDDqM7:TR?= MlvWNlQhcA>? MY\k[YNz\WG|ZYOgeIhmKGW6cILld5Nqd25ibHX2[Yx{KG:oIF7GMe67SiCjbnSgVE1oeMLi Mli4NlQzOjB5MkW=
FaDu M4TOZ2Z2dmO2aX;uJGF{e2G7 MW[yJIg> MXHpcohq[mm2czDwOlUh\XiycnXzd4lwdiCjbnSgZoxw[2u|IGTOSu6yNWmwZIXj[YQhXFeLU2Sg[ZhxemW|c3nvci=> NVKy[W9tOjR{MkC2NlI>
IVD  MYnGeY5kfGmxbjDBd5NigQ>? Ml7lNVDDqM7:TR?= NFn0OWo{KGR? NWLVc|d[emW4ZYLz[ZMhXE6ILd8x5qCUdWWmaXH0[YQhe3WycILld5Nqd25ib3[geIhmKGSrc3OgcYF1emm6IH3hZ5JwdW:uZXP1cIV{KGGpZ4LlZ4FvKGGwZDDjc4xt[WenbjDJTS=> M2rSV|I1OTd4OEC4
IVD  M{TDRWZ2dmO2aX;uJGF{e2G7 Mn\sNVDDqM7:TR?= MVuzJIQ> M1jr[IFjem:pYYTld{BVVkZvzsJihLNqdmS3Y3XkJJVxNXKnZ4XsZZRqd25ib3[gRWRCVVSVLUSgZY5lKEGGQV3UV{02yqB? M1fpfVI1OTd4OEC4
iNKT NXHMTlVGTnWwY4Tpc44hSXO|YYm= MlLkNVAwOTByIN88US=> NHGy[XMxNjViaB?= MXvpcohq[mm2czD0bIUhcW6mdXP0bY9vKG:oIFGyRXIhdVKQQTDhcoQhd3SqZYKg[oFkfG:{ MWSyOFEzPDR3Mx?=
PC-3 MVLGeY5kfGmxbjDBd5NigQ>? MkDJNk42NzVxMUCg{txO NXjj[nZqOC53IHi= Mn7VZoxw[2u|IFnHSk1KUS2rbnT1Z4VlKFOWUzDtVm5CKGW6cILld5Nqd28EoB?= NVX4fW1XOjRyNUW1NlA>
THP-1  MUTGeY5kfGmxbjDBd5NigQ>? Mor3NVDDqM7:TR?= NH7hUG4yyqCq NXvBdGVj[WKxbHnzbIV{KHSqZTDl[oZm[3Rib3[gdmhUWDJ5IH;uJHNTNUFibWLORS=> MmjvNlM6Ozl|OUi=
A549 NXjDe2xkTnWwY4Tpc44hSXO|YYm= NIPrNmoyyqEQvF2= MnXIOFghcA>? MWrlcohidmOnczD0bIUhfXBvcnXneYxifGmxbjDv[kBK|rqEIHHu[EB{fWK|ZYH1[Y51KGSnY4LlZZNmKGmwIFLhfEBmgHC{ZYPzbY9vKGmwZIXj[YQh[nliY3;tZolv\WRic4TpcZVt[XSrb36= MX:yN|kxODB6MB?=
A549 MnW0RZBweHSxc3nzJGF{e2G7 MYmxxsDPxE1? MV60PEBp M1fwO5Jm\HWlZYOgeIhmKGOnbHyg[IVifGhiaX7keYNm\CCkeTDjc41jcW6nZDDzeIlufWyjdHnvci=> NVq0bVByOjN7MECwPFA>
NCI-N87 MkmwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlm5NVAwOjBxM{Cg{txO NYjrbmJpPi9{NDDo NYjXOGVse3WycILld5NmeyClZXzsJJZq[WKrbHn0fUB{cWewaX\pZ4FvfGy7 M{XFcVI{QDR4NUS1
AGS M2q2c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWCxNE8zOC9|MDFOwG0> MmLXOk8zPCCq MmHzd5VxeHKnc4Pld{Bk\WyuII\pZYJqdGm2eTDzbYdvcW[rY3HueIx6 MlLENlM5PDZ3NEW=
MGC80-3 MlyxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn;ENVAwOjBxM{Cg{txO M2eyVVYwOjRiaB?= M{ewdJN2eHC{ZYPz[ZMh[2WubDD2bYFjcWyrdImgd4lodmmoaXPhcpRtgQ>? MkDxNlM5PDZ3NEW=
HGC-27  NHr4WZJHfW6ldHnvckBCe3OjeR?= MX23MlUwOTVxM{Cg{txO NEL1ZnA3KGh? M4XCO4lv\HWlZYOgeIhmKGSncHjvd5Bpd3K7bHH0bY9vKGGwZDD1dE1z\We3bHH0bY9vKG:oIFpOvmLPuQ>? MoPmNlM5PDZ3NEW=
MGC80-3 MnPuSpVv[3Srb36gRZN{[Xl? MljKO{42NzF3L{OwJO69VQ>? NULLPVlTPiCq NUTD[Jk2cW6mdXPld{B1cGViZHXwbI9{eGixconsZZRqd25iYX7kJJVxNXKnZ4XsZZRqd25ib3[gTe67Ss7z NGjyPGkzOzh2NkW0OS=>
HGC-27  MUDBdI9xfG:|aYOgRZN{[Xl? M1L3NVcvPS9zNT:zNEDPxE1? NFrVVFA3KGh? NGDac2pqdmS3Y3XzJIFxd3C2b4Ppd{BqdiCjIITpcYUuKGGwZDDkc5NmNWSncHXu[IVvfCCvYX7u[ZI> NXvlW45POjN6NE[1OFU>
HBE  NVjSb|F1TnWwY4Tpc44hSXO|YYm= M2q3blEx|ryP MmPTN4g> NUH5[ohp[WKxbHnzbIV{KHSqZTDpcoNz\WG|ZYOgc4YhUUxvNjDlfJBz\XO|aX;uJIlv\HWlZXSgZpkhS1OH M1\ITFI{QDJ2MEi5
HepG2 MVnGeY5kfGmxbjDBd5NigQ>? M3L6fVAvOy9zL{Og{txO MlHHOFghcA>? MmjqdoVlfWOnczDJUFYucW6mdXPl[EBRV05zIHX4dJJme3Orb36= NGD3N|czOzd7MUizNy=>
THP-1 NHfWeWxHfW6ldHnvckBCe3OjeR?= MkK1OUDDvU1? MYKxJIg> NWfmc2ZOTE2VTx?= M{D1T4lvcGmkaYTzJG1VSi2rbnT1Z4VlKE6IzsrCJIFkfGm4YYTpc44> NGm2d3AzOzZ|NEKxPC=>
THP-1  NIj2[lZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYHkSGE5PSEEtV2= NETORXY1NzhiZB?= M1Kxc2ROW09? NIXiVolz\WS3Y3XzJJRp\SC4aXHibYxqfHlib3[gbY51emGlZXzseYxiesLiTWTC MVKyN|Y{PDJzOB?=
MDM MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{OySFUhyrWP M4G3bVQwQCCm NF;VUWVFVVOR NGXGUVlz\WS3Y3XzJJRp\SC4aXHibYxqfHlib3[gbY51emGlZXzseYxiesLiTWTC NWPvRWl[OjN4M{SyNVg>
AM NIjN[YdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mmi4OUDDvU1? MkDJOE85KGR? NGDrb5VFVVOR MoXqdoVlfWOnczD0bIUhfmmjYnnsbZR6KG:oIHnueJJi[2WubIXsZZLDqE2WQh?= MWWyN|Y{PDJzOB?=
RAW 264  MWHGeY5kfGmxbjDBd5NigQ>? M3vaV|AvOi13INM1US=> M4nYZ|MxNzZyL{mwJI1qdg>? M4DBOYlvcGmkaYTzJJRp\SCyaH;zdIhifGG|ZTDhZ5Rqfmm2eTDv[kBRXFBzQtMg MYGyN|U4QDNyMh?=
HUVEC NGnrVo5HfW6ldHnvckBCe3OjeR?= M{fqZVExyqEQvF2= MmPZNE42KGh? NFrLcVZFVVOR M1fYZ4NwfW62ZYLhZ5RmeyC2aHWgcI9{eyCxZjDUbYUzKG2UTlG= NVLvOGl7OjN3NkO2N|I>
HT29 NUDlflZuTnWwY4Tpc44hSXO|YYm= M4PLW|ExNzNyL{GwNEDPxE1? MXyxJIg> NUjobpNkcW6qaXLpeIV{KGKxdHigWHdGSUtvaX7keYNm\CCyMUCwJJBzd2Onc4Ppcoc> MkDKNlM2OjdzNUS=
HT29 NVvqbm92TnWwY4Tpc44hSXO|YYm= MVGxNE8{OC9zMECg{txO NIDIepYyKGh? MXrpcohq[mm2czDUUmYucW6mdXPl[EBxcG:|cHjvdplt[XSrb36gZY5lKGSnZ4Lh[IF1cW:wIH;mJGnPwkMQsR?= NXPUV481OjN3MkexOVQ>
MM.1S NFr0eoZCeG:ydH;zbZMhSXO|YYm= MYKzNEDDvU1? NWr3e29FOyCq MmjmbY5lfWOnczDNUUBk\WyuIHTlZZRpKGmwdn;seoV{KG6nY4Lvd4l{ NEXNcXIzOzV{N{G1OC=>
KMS-12-BM Mmf0RZBweHSxc3nzJGF{e2G7 MlrsN|AhyrWP MmWyN{Bp M2TwWIlv\HWlZYOgUW0h[2WubDDk[YF1cCCrbo\vcJZmeyCwZXPyc5Nqew>? NFnJOYMzOzV{N{G1OC=>
BAFs NYjHbGtwTnWwY4Tpc44hSXO|YYm= Mmj5NE42NzIEoN88US=> MWeyOEBp NFfkZ2JqdmirYnn0d{BVVkcQsT;ESXghcW6mdXPl[EBEYVBzOVGxxsB1emGwc3PybZB1ew>? M1zDU|I{PDh3NEW3
SP6.5 M4n6VGZ2dmO2aX;uJGF{e2G7 M2DKXVUh|ryP NVvObY52OiCq MV\k[YNz\WG|ZYRCpJRz[W6|bH;jZZRqd25ib3[gdFY2KGmwIITo[UBvfWOuZYXzxsA> M{nre|I{PDR|MEi2
VUP NEmzW5NHfW6ldHnvckBCe3OjeR?= M2PmTFUh|ryP NULxU29vOiCq NV7U[pM6\GWlcnXhd4V{yqC2cnHud4xw[2G2aX;uJI9nKHB4NTDpckB1cGViboXjcIV2e8Li M1Hu[FI{PDR|MEi2
OCM1 NYHJe5FTTnWwY4Tpc44hSXO|YYm= M13hTFUh|ryP MWSyJIg> M3zjc4Rm[3KnYYPld:KhfHKjboPsc4NifGmxbjDv[kBxPjViaX6geIhmKG63Y3zleZPDqA>? NWXSeoVNOjN2NEOwPFY>
OM431 NF3XU2VHfW6ldHnvckBCe3OjeR?= M3jaVlUh|ryP NGjEW5czKGh? NU\xT2pu\GWlcnXhd4V{yqC2cnHud4xw[2G2aX;uJI9nKHB4NTDpckB1cGViboXjcIV2e8Li MnHUNlM1PDNyOE[=
SP6.5 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEnzV3kzNjVvMkCg{txO M3XzPVI1KGkEoB?= NVuySGxvUUN3ME21JO69VSxiZYjobYJqfHNic4Tyc45oKGGwdHmtdJJwdGmoZYLheIl3\SCnZn\lZ5R{KGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoVz MkOwNlM1PDNyOE[=
VUP MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV7GSI1EOi53LUKwJO69VQ>? NVjoeXRFOjRiaNMg NGLHfZpKSzVyPUWg{txONCCneHjpZol1eyC|dILvcoch[W62aT3wdo9tcW[ncnH0bZZmKGWoZnXjeJMhcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7u[ZI> MYGyN|Q1OzB6Nh?=
OCM1 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYLWVFR7Oi53LUKwJO69VQ>? NGjhTFkzPCCqwrC= NWnDZXdxUUN3ME21JO69VSxiZYjobYJqfHNic4Tyc45oKGGwdHmtdJJwdGmoZYLheIl3\SCnZn\lZ5R{KGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoVz MV2yN|Q1OzB6Nh?=
OM431 NEjPfXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHnZ2IzNjVvMkCg{txO NImzN3IzPCCqwrC= MYLJR|UxRTVizszNMEBmgGirYnn0d{B{fHKxbnegZY51cS2ycn;sbYZmemG2aY\lJIVn\mWldIOgbY4h[SCmb4PlMYRmeGWwZHXueEBu[W6wZYK= NGfhe|AzOzR2M{C4Oi=>
SP6.5 M3\TcmFxd3C2b4Ppd{BCe3OjeR?= MmLWOUDPxE1? NVHPTlk6OjRiaNMg MnrNbY5lfWOnczDhdI9xfG:|aYRCpC=> NIPae|UzOzR2M{C4Oi=>
VUP NWDkOmpwSXCxcITvd4l{KEG|c3H5 MWm1JO69VQ>? NYC4[IlnOjRiaNMg Mn\3bY5lfWOnczDhdI9xfG:|aYRCpC=> MofmNlM1PDNyOE[=
OCM1 NHWwUXFCeG:ydH;zbZMhSXO|YYm= MWO1JO69VQ>? MUOyOEBpyqB? M{THbIlv\HWlZYOgZZBweHSxc3nzxsA> NGDDbWMzOzR2M{C4Oi=>
OM431 NEDtWGtCeG:ydH;zbZMhSXO|YYm= NWPwT4pXPSEQvF2= NIPSflAzPCCqwrC= NEPlTlRqdmS3Y3XzJIFxd3C2b4Ppd:Kh NWP3XoRlOjN2NEOwPFY>
SP6.5 MXLGeY5kfGmxbjDBd5NigQ>? MmPaOUDPxE1? MWKxNkBp M1vBNpJm\HWlZYOgeIhmKG2rZ4LheIlwdsLi M3XHc|I{PDR|MEi2
VUP MVrGeY5kfGmxbjDBd5NigQ>? MV:1JO69VQ>? Ml\YNVIhcA>? Mni0doVlfWOnczD0bIUhdWmpcnH0bY9vyqB? MYOyN|Q1OzB6Nh?=
OCM1 MWjGeY5kfGmxbjDBd5NigQ>? NWPFTYNVPSEQvF2= NHzSUlgyOiCq NYjSSpNNemWmdXPld{B1cGVibXnndoF1cW:wwrC= MXyyN|Q1OzB6Nh?=
OM431 MVLGeY5kfGmxbjDBd5NigQ>? NIqzN4I2KM7:TR?= NGDlOGsyOiCq M4HMZZJm\HWlZYOgeIhmKG2rZ4LheIlwdsLi M33CXFI{PDR|MEi2
HBL-1  MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHnPOWc{yqEQvF2= MkDvNlQwPDhxN{KgbC=> M3fRemROW09? Mn\Nd4xwf3NiY3XscEBoem:5dHigcY9l\XO2bIm= NYfjU2VvOjN2NEG3N|A>
RAW 264.7 MXPGeY5kfGmxbjDBd5NigQ>? NGHWV3MzNTF3IN88US=> M3XT[lEhcA>? NGm1OphFVVOR NILseo1{fXCycnXzd4V{KHSqZTDhZ5RqfmG2aX;uJI9nKEmNSzDmZY1qdHlibXXtZoVzew>? NYDTb29NOjN2NEG3N|A>
IL-1R  NGnKRlVHfW6ldHnvckBCe3OjeR?= MX:yMVE2KM7:TR?= M3XJ[VEhcA>? M3uyb2ROW09? MoX0d5VxeHKnc4Pld{B1cGViYXP0bZZifGmxbjDv[kBKU0tiZnHtbYx6KG2nbXLldpM> Mnz5NlM1PDF5M{C=
RAW 264.7 M17B[WZ2dmO2aX;uJGF{e2G7 M{G3bVE2KM7:TR?= MUWxJIg> M{jSPGROW09? MlPhd5VxeHKnc4Pld{B1cGViYXP0bZZifGmxbjDv[kBidmRiSl7L MWOyN|Q1OTd|MB?=
IL-1R  NXLyfHFrTnWwY4Tpc44hSXO|YYm= M1LCWlE2KM7:TR?= MUixJIg> M{HiSWROW09? NHHUc2t{fXCycnXzd4V{KHSqZTDhZ5RqfmG2aX;uJI9nKGGwZDDKUms> NG\qPHUzOzR2MUezNC=>
U2OS MorMSpVv[3Srb36gRZN{[Xl? MmrxNVUh|ryP MVqxJIg> M2TEfWROW09? NUPU[Y9QeHKndnXueJMhfGinIFzQV{0hd3JiSVytNU1{fGmvdXzheIVlKG[xcn3heIlwdiCxZjDLOlMueFWkIHPoZYlve8Li M3S5cVI{PDRzN{Ow
MT‐1  NVG1SYZSTnWwY4Tpc44hSXO|YYm= MmDjPOKhyrWv M3z6TlMhcA>? NUjSXHhZ\GWlcnXhd4V{KHSqZTDs[ZZmdHNib3[gdQKBmFOWQWSzJIFv\CCy4pEQOGVDWDF? MYeyN|I4QDR5OR?=
MT‐2  MlLESpVv[3Srb36gRZN{[Xl? NYDQOFVCQMLiwsXt NX:0TWFQOyCq M4nKZYRm[3KnYYPld{B1cGVibHX2[Yx{KG:oIIFihLBUXEGWMzDhcoQheOLCkETFRnAy MVmyN|I4QDR5OR?=
MT‐1  MU\GeY5kfGmxbjDBd5NigQ>? M1zIZ|jDqML3bR?= MorFN{Bp NYfvb|N5\GWlcnXhd4V{KHSqZTDs[ZZmdHNib3[geIhmKHB4NTDzeYJ2dmm2IH;mJG5H6oDSzsrCxsA> NYjCbHpGOjN{N{i0O|k>
MT‐2  NH:3PZVHfW6ldHnvckBCe3OjeR?= MWq4xsDDvW1? NXi4TlkzOyCq NWOxd3Fz\GWlcnXhd4V{KHSqZTDs[ZZmdHNib3[geIhmKHB4NTDzeYJ2dmm2IH;mJG5H6oDSzsrCxsA> NGTrS5IzOzJ5OES3PS=>
MCF-7  MUPGeY5kfGmxbjDBd5NigQ>? MWmyMlUuOTVizszN MmPqNE42KGh? NGLIOWRFVVOR NITsSIFk[XW|ZYOgeIhmKGe{YXT1ZYwhdG:|czDv[kBk\WyuIHHkbIV{cW:w M3rBVlI{ODl|MkK3
HaCaT  NYDnS4ExTnWwY4Tpc44hSXO|YYm= NWqwT2xqPS5ywrFOwG0> MVOxxsBpyqB? M{fMSYF1fGWwdXH0[ZMhfGinIGTDU2gucW6mdXPl[EBxem:mdXP0bY9vKG:oIFnMMVbDqA>? NVzFbXAzOjNyNEGxOlg>
A549  M2nQc2Z2dmO2aX;uJGF{e2G7 NXft[nlQOSCq NWS0RlczcW6qaXLpeJMhVFSDLXnu[JVk\WRiU2CtRUBuWk6DIIDyc4R2[3Srb39CpJNq\26rZnnjZY51dHl? Mmr5NlMxOzF{MUO=
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RAW264.7 Mm\IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVi1MVMxKM7:TR?= Ml;WNlQhcA>? NG\nTGZqdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDhJIRwe2VvZHXw[Y5l\W62IH3hco5meg>? MWGyNlc1PTV{Mx?=
HBL6 NUjxZll1SXCxcITvd4l{KEG|c3H5 Mk\3NE42NzVxMkWg{txO NXi3TGRyPi9{NDDo M1XGcoRm[3KnYYPld{Bk\WyuII\pZYJqdGm2eTDhcoQhdGWnYXTzJJRwKGGyb4D0c5NqeyCrbjDhJIRwe2VvZHXw[Y5l\W62IH3hco5mesLi NGjFWWczOjB5NEiyNC=>
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Ca9–22 NHO0SnJHfW6ldHnvckBCe3OjeR?= NUj6RplPOTEEoN88UeKh M4fjVlEhcA>? NELW[o5kd22ybHX0[Yx6KGGkcn;nZZRmeyC2aHWgRWxCNVCGVD3pcoR2[2WmIFrOT{Bi[3SrdnH0bY9v Mor4NlEyOzh2OEC=
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... Click to View More Cell Line Experimental Data

Protocol

Cell Research:[2]
+ Expand
  • Cell lines: NCI-H1703 cells
  • Concentrations: ~8 μM
  • Incubation Time: 12 hours
  • Method: Cells are transfected with siRNA in 96-well microtiter plates and then cultured for 72 hours in complete NSCLC medium, treated with BAY 11-7082 for 12 hours. Cells are incubated with [3H]thymidine for 3 hours. The cells are collected on filters using an automatic cell harvester and radioactivity on the filters is measured by β-scintillation counting.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 41 mg/mL (197.82 mM)
Ethanol 10 mg/mL (48.25 mM)
Water slightly soluble or insoluble
In vivo Add solvents individually and in order:
5% DMSO+corn oil
8mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 207.25
Formula

C10H9NO2S

CAS No. 19542-67-7
Storage powder
in solvent
Synonyms BAY 11-7821

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID