BAY 11-7082

Catalog No.S2913 Synonyms: BAY 11-7821

BAY 11-7082 Chemical Structure

Molecular Weight(MW): 207.25

BAY 11-7082 is a NF-κB inhibitor, inhibits TNFα-induced IκBα phosphorylation with IC50 of 10 μM in tumor cells. Also inhibiting components of the ubiquitin system.

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In DMSO USD 120 In stock
USD 90 In stock
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3 Customer Reviews

  • Immunofluorescence images of Ishikawa cells showing the increase in the nuclear colocalization of ERa (red) and p65 (green) after E2 incubation. Nuclear colocalization is yellow. Treatment with ICI 182,780, PDTC or Bay inhibited the nuclear localization of both ERa and p65. Blue, DAPI-stained nuclei. All pictures were obtained the same day using the same microscope settings. Original magnification 3200, bar =50 um. Arrows, cytoplasmic ERa and p65 staining. ICI, ICI 182,780; Bay, Bay 11-7082.

    Int J Cancer 2014 135(2), 282-94. BAY 11-7082 purchased from Selleck.

    Shown are Western blot analysis of Wnt5a expression in HDPCs treated with TNF-a (n=3–4). The gene expression level was normalized to GAPDH (n = 3–6). HDPCs were preincubated with pyrrolidinedithiocarbamic acid (PDTC, an NF-κB inhibitor), BAY11-7082 (an NF-κB inhibitor), SP600125 (a JNK inhibitor), SB203580 (a p38 inhibitor), or U0126 (an ERK inhibitor) before treatment with TNF-a.

    J Biol Chem 2014 289(30), 21028-21039. BAY 11-7082 purchased from Selleck.

  • The effect of vaspin on TNF α -induced THP-1 cell adhesion to HAECS measured staining with VibrantDiO® Cell-Labeling Solution. The level of THP-1 cell adhesion to HAECs was measured at 4 hr after treatment with 25 -100 ng/mL vaspin in the presence or absence of 10 ng/mL TNF α . BAY11-7082 (10 uM, S2913, Selleckchem, USA), an inhibitor of NF- κ B, was used as a positive control.

    Cardiovasc Diabetol 2014 13, 41. BAY 11-7082 purchased from Selleck.

Purity & Quality Control

Choose Selective IκB/IKK Inhibitors

Biological Activity

Description BAY 11-7082 is a NF-κB inhibitor, inhibits TNFα-induced IκBα phosphorylation with IC50 of 10 μM in tumor cells. Also inhibiting components of the ubiquitin system.
Targets
E2-conjugating enzymes [6]
(Cell-free assay)
IκBα phosphorylation [1]
(Tumor cells)
10 μM
In vitro

BAY 11-7082 completely and specifically abrogates NF-κB DNA binding, downregulating the NF-κB-inducible cytokine IL-6 and inducing apoptosis. [1] BAY 11-7082 (< 8 μM) is able to effectively inhibit both basal and TNFα stimulated NFκB luciferase activity in a dose dependent manner. BAY 11-7082 (8 μM) strongly inhibits the rate of proliferation in NCI-H1703 cells. [2] Bay 11-7082 (5 μM) rapidly and efficiently reduces the DNA binding of NF-kappaB in HTLV-I-infected T-cell lines and down-regulates the expression of the antiapoptotic gene, Bcl-x(L), whereas it has little effect on the DNA binding of another transcription factor, AP-1. Bay 11-7082-induced apoptosis of primary ATL cells is more prominent than that of normal peripheral blood mononuclear cells, and apoptosis of these cells is also associated with down-regulation of NF-kappaB activity. Bay 11-7082 (5 μM) selectively induces apoptosis of HTLV-I–infected T-cell lines associated with down-regulation of the expression of cyclin D1, cyclin D2, and Bcl-xL. [3] BAY 11-7082 (100 μM) prevents the nuclear translocation of p65 elicited by NMDA and the NMDA-induced increase of NF-κB binding in mouse hippocampal slices. BAY 11-7082 prevents NMDA toxicity occurring in CA1 region of hippocampal slices with 40% neuroprotection at 20 μM and 70% neuroprotection at 100 μM. [4] BAY 11-7082 at all concentrations tested significantly inhibits NF-κB p65 DNA-binding activity in adipose tissue, whereas in skeletal muscle, BAY 11-7082 at 50 μM and 100 μM significantly inhibits NF-κB p65 DNA-binding activity. BAY 11-7082 (100 μM) reduces IKK-β protein in human adipose tissue and skeletal muscle. BAY 11-7082 (100 μM) significantly decreases the release of TNF-α from adipose tissue, whereas the release of IL-6 and IL-8 is significantly inhibited at all concentrations of BAY 11-7082 tested. BAY 11-7082 (50 μM) significantly decreases the release of TNF-α, IL-6, and IL-8 in skeletal muscle. [5] BAY 11-7082 is also found to inactivate the E2-conjugating enzymes Ubc (ubiquitin conjugating) 13 and UbcH7 and the E3 ligase LUBAC (linear ubiquitin assembly complex), and thus induces B-cell lymphoma and leukaemic T-cell death. [6]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HeLa NW\U[GtUTnWwY4Tpc44hSXO|YYm= M1LwXFExyqEQvF2= NFn1WHoyNjViaB?= MnvFZYJwdGm|aHXzJGJRSSCrbnT1Z4VlKHWyIILl[5Vt[XSrb36gc4YhTk5iYX7kJG1OWC17wrC= MmWxNlU4QTd2M{e=
SiHa  NUX1dZVZTnWwY4Tpc44hSXO|YYm= M33BcFExyqEQvF2= MWOxMlUhcA>? NVTRd|JI[WKxbHnzbIV{KEKSQTDpcoR2[2WmIIXwJJJm\3WuYYTpc44hd2ZiRl6gZY5lKE2PUD25xsA> NUTiR45GOjV5OUe0N|c>
ARPE-19 MkXVSpVv[3Srb36gRZN{[Xl? M17jZVEh|ryP MYKwMlUhcA>? M1nUVpN2eHC{ZYPz[ZMhXEdvaX7keYNm\MLiSVytPOKheHKxbX;0[ZIh[WO2aY\heIlwdg>? MY[yOVU6OzB{OR?=
HCT116 MYPGeY5kfGmxbjDBd5NigQ>? MXq1JO69VQ>? NYW0VnRNOiCq M3frdWROW09? MXjheJRmdnWjdHXzJJNqdHmvYYLpck1qdmS3Y3XkJIRwf26{ZXf1cIF1cW:wIH;mJIN6[2yrbjDENS=> MofuNlU1Pzl5MkO=
HMECs MkL3SpVv[3Srb36gRZN{[Xl? NHS0emM2yqEQvF2= NEXXT4kzKGh? M2fFVYFjd2yrc3jld{BVVkZvzsGtbY5lfWOnZDDWR2FONTFiZYjwdoV{e2mxbtMg MX2yOVE6OzFzNh?=
A549  NUHOUI5OTnWwY4Tpc44hSXO|YYm= MWixNQKBkcL3TR?= MlfONVIhcA>? MVrzeZBxemW|c3XzJGR3dC1|IHnu[JVk\WRiYXP0bZZifGmxbjDv[kBxPjV? Ml3jNlUyPTZ6MEC=
RAW 264.7 NHvUOY9HfW6ldHnvckBCe3OjeR?= NGD0VZI2yqEQvF2= MVmxJIg> NX\PeWxncW6qaXLpeJMhXE6ILd8xJIFv\CCLTD2xNkBxPDBicILv[JVkfGmxbh?= MoLtNlUxOTl3Nke=
macrophages M2rTRWZ2dmO2aX;uJGF{e2G7 MUe1JOK2VQ>? NGS4Z2c{KGh? MYfwZZJ1cWGubImgZoxw[2u|IGnQSnMucW6mdXPl[EBmgHC{ZYPzbY9vKG:oIHnOU3Mh[W6mIFPPXE0zyqB? MX[yOFk3Pzh7OB?=
HUVECs NX7lXVRCTnWwY4Tpc44hSXO|YYm= M37Md|MuOzBizszN MXuxJIg> M{TzVJJm\HWlZYOgeIhmKGW6cILld5Nqd25ib3[gcYlTNTF2NnGgbY4h[SCmb4PlMYRmeGWwZHXueEBu[W6wZYK= MoTmNlQ5PjN7NkW=
HeLa  MYLGeY5kfGmxbjDBd5NigQ>? M1nS[FXDqM7:TR?= M2PmWVI1KGh? MYLEUXNQ Mo\pdoVlfWOnczD0bIUh[WO2aY\peJkhd2ZiVF7GMe6yKHC{b33veIVzyqB? NFXGfHUzPDZ3N{e4Ny=>
A549 NVXIXoRJTnWwY4Tpc44hSXO|YYm= MUWxNEDPxE1? NXez[oM5OeLCiXi= MkDUbY5pcWKrdIOgeIhmKGmwY4LlZZNmKG:oIIDoc5NxcG9vSd86Ru6yKGmwIGDBNVA{NWmwZnXjeIVlKGO3bIT1doV{yqB? NGHXZo4zPDZzMkS4PC=>
HUVEC NH73UllHfW6ldHnvckBCe3OjeR?= NFXpZ5EzOCEEtV2= M{DsR|AvPSCq MmjCSG1UVw>? NYC1e5p1eHKndnXueJMhfGinIHnu[JVkfGmxbjDv[kBGSU1iZYjwdoV{e2mxbh?= NF7YOHozPDV3MUKwPS=>
A549RT-eto MlLtRZBweHSxc3nzJGF{e2G7 MnvnNVDDqM7:TR?= NYTYRVNFOjRiaB?= MmfWSG1UVw>? MlnsZYNk\WyncnH0[ZMhTkWUTz3t[YRq[XSnZDDhdI9xfG:|aYO= MmHRNlQ2OzVyOEO=
THP-1  MVHGeY5kfGmxbjDBd5NigQ>? NFmyZVYxNjFxMdMg{txO MlvCNE42KGh? NUnPbHYz[WK{b3fheIV{KFSQRj5OtUB{\WO{ZYTpc44h[XNid3XscEBieyC2aHWgbY5kemWjc3XkJJNm[3KndHnvckBw\iCLTD22JIFv\CCLTD2x{tI> MVSyOFM4QDV|Nh?=
SKCXCR2  M3PWcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXuyUm12OiEEtV2= NWfFNWl7PDhiaB?= NVXjSWlC\GWlcnXhd4V{KGOnbHygdJJwdGmoZYLheIlwdiC|aXfubYZq[2GwdHz5 NID4T2MzPDN5Nke0Oy=>
SKCXCR2  M3PHTGZ2dmO2aX;uJGF{e2G7 NG\6fVIzKML3TR?= NGLaN5M1QCCq NETuN2FjdG:la4OgeIhmKEO[Q1yxMYlv\HWlZXSgZ4VtdCCrbo\hd4lwdg>? NX33do4zOjR|N{[3OFc>
OVCXCR2 MkPhSpVv[3Srb36gRZN{[Xl? MmjsNkDDvU1? NFPKdms1QCCq NVfBZ3lo[myxY3vzJJRp\SCFWFPMNU1qdmS3Y3XkJINmdGxiaX72ZZNqd25? MVmyOFM4Pjd2Nx?=
DSCs  MkTaSpVv[3Srb36gRZN{[Xl? MXKyMlUh|ryP NVHte2tFOC53IHi= MoX4doV3\XK|ZYOgeIhmKGWwaHHuZ4Vu\W62IH;mJGNEVDJxQ1PSNkBmgHC{ZYPzbY9vKG:oIFTTR5MhcW6mdXPl[EBjgSCLTD2zNy=> MYKyOFM1PDJ2MB?=
WPs Mn\xSpVv[3Srb36gRZN{[Xl? M3rwclI2KM7:TR?= NWD6PYxOPSCvaX6= NHzx[nN{fXCycnXzd4V{KEGWUDDhcoQhfleIIIPlZ5JmfGmxbh?= M{T4bFI1OzNzMkC3
A549RT-eto NU[3NGl2SXCxcITvd4l{KEG|c3H5 M1LBPFExyqEQvF2= M{[yeFI1KGh? MXPhZ4NmdGW{YYTld{BHOTRiZYj0doFkfC2vZXTpZZRm\CCjcH;weI9{cXNiY3;tZolv\WRidILlZZRu\W62IIfpeIghTjF2 MVGyOFIzODd{NR?=
A549RT-eto M2\wc2Z2dmO2aX;uJGF{e2G7 Mn\ONVDDqM7:TR?= NH2wO40zPCCq NXfZOZUz\GWlcnXhd4V{KHSqZTDlfJBz\XO|aX;uJIxmfmWuczDv[kBPTi4QulKgZY5lKFBvZ4FCpC=> NX\6cHJzOjR{MkC3NlU>
FaDu NV\Fd291TnWwY4Tpc44hSXO|YYm= NXzYOWc4OiCq MofmbY5pcWKrdIOgdFY2KGW6cILld5Nqd25iYX7kJIJtd2OtczDUUmbPuS2rbnT1Z4VlKFSZSWPUJIV5eHKnc4Ppc44> MoT2NlQzOjB4MkK=
IVD  MnXuSpVv[3Srb36gRZN{[Xl? M1vhWlExyqEQvF2= NED1WXE{KGR? NEjOOHRz\X[ncoPld{BVVkZvzsJihLNu\WSrYYTl[EB{fXCycnXzd4lwdiCxZjD0bIUh\Gm|YzDtZZRzcXhibXHjdo9ud2ynY4Xs[ZMh[WepcnXjZY4h[W6mIHPvcIxi\2WwIFnJ NEHrfZAzPDF5NkiwPC=>
IVD  NX:2T4llTnWwY4Tpc44hSXO|YYm= M3fFfFExyqEQvF2= NGqxOFk{KGR? MYjhZpJw\2G2ZYOgWG5HNc7z4pETbY5lfWOnZDD1dE1z\We3bHH0bY9vKG:oIFHERW1VWy12IHHu[EBCTEGPVGOtOeKh MmTPNlQyPzZ6MEi=
iNKT NH73fHFHfW6ldHnvckBCe3OjeR?= Mn;NNVAwOTByIN88US=> NWm3dGUxOC53IHi= M3fYb4lvcGmkaYTzJJRp\SCrbnT1Z5Rqd25ib3[gRVJCWiCvUl7BJIFv\CCxdHjldkBn[WO2b4K= MVSyOFEzPDR3Mx?=
PC-3 NVHEc2xzTnWwY4Tpc44hSXO|YYm= NHPCSG4zNjVxNT:xNEDPxE1? Mn63NE42KGh? NVfPNlhW[myxY3vzJGlITi2LST3pcoR2[2WmIGPUV{BuWk6DIHX4dJJme3Orb39CpC=> MV[yOFA2PTV{MB?=
THP-1  M{i5XmZ2dmO2aX;uJGF{e2G7 NXHudI14OTEEoN88US=> MlexNeKhcA>? MmTDZYJwdGm|aHXzJJRp\SCnZn\lZ5Qhd2ZicljTVFI4KG:wIGPSMWEhdVKQQR?= MoPMNlM6Ozl|OUi=
A549 MlX1SpVv[3Srb36gRZN{[Xl? NH3we4wyyqEQvF2= M1;JRVQ5KGh? NEDwPJlmdmijbnPld{B1cGVidYCtdoVofWyjdHnvckBw\iCLzsrCJIFv\CC|dXLz[ZF2\W62IHTlZ5Jm[XOnIHnuJGJigCCneIDy[ZN{cW:wIHnu[JVk\WRiYomgZ49u[mmwZXSgd5RqdXWuYYTpc44> NEjZO2QzOzlyMEC4NC=>
A549 M{jCXWFxd3C2b4Ppd{BCe3OjeR?= NGHFWVUyyqEQvF2= MnG1OFghcA>? MkDldoVlfWOnczD0bIUh[2WubDDk[YF1cCCrbnT1Z4VlKGK7IHPvcYJqdmWmIIP0bY12dGG2aX;u M3nYXFI{QTByMEiw
NCI-N87 M1SyS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlL2NVAwOjBxM{Cg{txO MkPjOk8zPCCq NWj3e45De3WycILld5NmeyClZXzsJJZq[WKrbHn0fUB{cWewaX\pZ4FvfGy7 NIXkb4wzOzh2NkW0OS=>
AGS NY\YU5lvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXyxNE8zOC9|MDFOwG0> NXn1TmdRPi9{NDDo MkO5d5VxeHKnc4Pld{Bk\WyuII\pZYJqdGm2eTDzbYdvcW[rY3HueIx6 MXOyN|g1PjV2NR?=
MGC80-3 MmTmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYexNE8zOC9|MDFOwG0> MojjOk8zPCCq NIPjbZl{fXCycnXzd4V{KGOnbHygeoli[mmuaYT5JJNq\26rZnnjZY51dHl? NIPxVm8zOzh2NkW0OS=>
HGC-27  NXz2WI1wTnWwY4Tpc44hSXO|YYm= MVG3MlUwOTVxM{Cg{txO MWW2JIg> NWmyUGsxcW6mdXPld{B1cGViZHXwbI9{eGixconsZZRqd25iYX7kJJVxNXKnZ4XsZZRqd25ib3[gTe67Ss7z NHrNXYkzOzh2NkW0OS=>
MGC80-3 MV7GeY5kfGmxbjDBd5NigQ>? NELaOIE4NjVxMUWvN|Ah|ryP NUfHe4ZpPiCq NEjWeYRqdmS3Y3XzJJRp\SCmZYDoc5NxcG:{eXzheIlwdiCjbnSgeZAuemWpdXzheIlwdiCxZjDJ{tpD|rF? NFXsTZozOzh2NkW0OS=>
HGC-27  M1f4U2Fxd3C2b4Ppd{BCe3OjeR?= MnPlO{42NzF3L{OwJO69VQ>? MkPXOkBp MmfFbY5lfWOnczDhdI9xfG:|aYOgbY4h[SC2aX3lMUBidmRiZH;z[U1l\XCnbnTlcpQhdWGwbnXy MUKyN|g1PjV2NR?=
HBE  NWXpXopWTnWwY4Tpc44hSXO|YYm= MVyxNO69VQ>? NFPqVZU{cA>? NHj2V2di[m:uaYPo[ZMhfGinIHnuZ5Jm[XOnczDv[kBKVC14IHX4dJJme3Orb36gbY5lfWOnZDDifUBEW0V? Ml31NlM5OjRyOEm=
HepG2 NVy4e254TnWwY4Tpc44hSXO|YYm= MV6wMlMwOS9|IN88US=> NHPIVlY1QCCq Ml7pdoVlfWOnczDJUFYucW6mdXPl[EBRV05zIHX4dJJme3Orb36= NYLV[pRHOjN5OUG4N|M>
THP-1 MXfGeY5kfGmxbjDBd5NigQ>? NWHJbng1PSEEtV2= NXr3Rm5qOSCq Mo[2SG1UVw>? MWrpcohq[mm2czDNWGIucW6mdXPl[EBPTs78QjDhZ5RqfmG2aX;u M2DyRVI{PjN2MkG4
THP-1  NEHY[25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPEfmE2KML3TR?= NHnUbGM1NzhiZB?= NV6zUmpSTE2VTx?= MVjy[YR2[2W|IITo[UB3cWGkaXzpeJkhd2ZiaX70doFk\WyudXzhduKhVVSE M3LOTFI{PjN2MkG4
MDM NYXyc4QxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MW[1JOK2VQ>? M4TIOFQwQCCm M3q1VWROW09? Mn7OdoVlfWOnczD0bIUhfmmjYnnsbZR6KG:oIHnueJJi[2WubIXsZZLDqE2WQh?= NVroSVNiOjN4M{SyNVg>
AM NGXzSIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHZfZo2KML3TR?= M4rBS|QwQCCm NUnNZpZlTE2VTx?= M2LpWZJm\HWlZYOgeIhmKH[rYXLpcIl1gSCxZjDpcpRz[WOnbHz1cIFzyqCPVFK= MUCyN|Y{PDJzOB?=
RAW 264  MVTGeY5kfGmxbjDBd5NigQ>? MYKwMlIuPSEEtV2= M3jHUlMxNzZyL{mwJI1qdg>? NV3Dd4FocW6qaXLpeJMhfGinIIDoc5NxcGG2YYPlJIFkfGm4aYT5JI9nKFCWUEHCxsA> NWnXeW1JOjN3N{izNFI>
HUVEC NEXWfIFHfW6ldHnvckBCe3OjeR?= M33obVExyqEQvF2= MWmwMlUhcA>? NILMWm1FVVOR NVTmSYRp[2:3boTldoFkfGW|IITo[UBtd3O|IH;mJHRq\TJibWLORS=> Mof2NlM2PjN4M{K=
HT29 NWrTR4JyTnWwY4Tpc44hSXO|YYm= Mn3aNVAwOzBxMUCwJO69VQ>? MoTPNUBp M2KxWolvcGmkaYTld{Bjd3SqIGTXSWFMNWmwZIXj[YQheDFyMDDwdo9k\XO|aX7n M17peVI{PTJ5MUW0
HT29 MWnGeY5kfGmxbjDBd5NigQ>? M3m3XVExNzNyL{GwNEDPxE1? MoHJNUBp M1K5[YlvcGmkaYTzJHRPTi2rbnT1Z4VlKHCqb4PwbI9zgWyjdHnvckBidmRiZHXndoFl[XSrb36gc4YhUc78Qt8x NFLCV4EzOzV{N{G1OC=>
MM.1S MWfBdI9xfG:|aYOgRZN{[Xl? Ml\VN|AhyrWP NHKxS3o{KGh? MX3pcoR2[2W|IF3NJINmdGxiZHXheIghcW64b3z2[ZMhdmWlcn;zbZM> NHruVFIzOzV{N{G1OC=>
KMS-12-BM M1HuZWFxd3C2b4Ppd{BCe3OjeR?= NGGy[m4{OCEEtV2= NFrVbWU{KGh? NIryU5JqdmS3Y3XzJG1OKGOnbHyg[IVifGhiaX72c4x3\XNibnXjdo9{cXN? MXyyN|UzPzF3NB?=
BAFs M{XscGZ2dmO2aX;uJGF{e2G7 MmjvNE42NzIEoN88US=> NIfXXogzPCCq Ml\DbY5pcWKrdIOgWG5H|rFxRFXYJIlv\HWlZXSgR3lROTmDMdMgeJJidnOlcnnweJM> MlXtNlM1QDV2NUe=
SP6.5 MkHRSpVv[3Srb36gRZN{[Xl? NUHDfFhVPSEQvF2= M4\HTlIhcA>? NIHOV2hl\WO{ZXHz[ZPDqHS{YX7zcI9k[XSrb36gc4YheDZ3IHnuJJRp\SCwdXPs[ZV{yqB? MUCyN|Q1OzB6Nh?=
VUP NYjofIJPTnWwY4Tpc44hSXO|YYm= MV61JO69VQ>? NG\wbFUzKGh? NXTkW2R[\GWlcnXhd4V{yqC2cnHud4xw[2G2aX;uJI9nKHB4NTDpckB1cGViboXjcIV2e8Li M1raNFI{PDR|MEi2
OCM1 NVGwOZpwTnWwY4Tpc44hSXO|YYm= NFvyN4c2KM7:TR?= MWiyJIg> MW\k[YNz\WG|ZYRCpJRz[W6|bH;jZZRqd25ib3[gdFY2KGmwIITo[UBvfWOuZYXzxsA> NHG0b3EzOzR2M{C4Oi=>
OM431 MWnGeY5kfGmxbjDBd5NigQ>? NYXPfXoxPSEQvF2= M{LxNlIhcA>? M3H2cIRm[3KnYYPld:KhfHKjboPsc4NifGmxbjDv[kBxPjViaX6geIhmKG63Y3zleZPDqA>? MVmyN|Q1OzB6Nh?=
SP6.5 NYXX[ldUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmjjNk42NTJyIN88US=> MUCyOEBpyqB? NH3zO4VKSzVyPUWg{txONCCneHjpZol1eyC|dILvcoch[W62aT3wdo9tcW[ncnH0bZZmKGWoZnXjeJMhcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7u[ZI> NWntcXI1OjN2NEOwPFY>
VUP Mn3rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4jjUFIvPS1{MDFOwG0> Ml\lNlQhcMLi MYfJR|UxRTVizszNMEBmgGirYnn0d{B{fHKxbnegZY51cS2ycn;sbYZmemG2aY\lJIVn\mWldIOgbY4h[SCmb4PlMYRmeGWwZHXueEBu[W6wZYK= NUHJWJl[OjN2NEOwPFY>
OCM1 NELybnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYjTdZBYOi53LUKwJO69VQ>? NIjuNVAzPCCqwrC= M1PRTGlEPTB;NTFOwG0tKGW6aHnibZR{KHO2cn;u[{BidnSrLYDyc4xq\mW{YYTpeoUh\W[oZXP0d{BqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7ldi=> NF6xV3YzOzR2M{C4Oi=>
OM431 M1jzXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3u3cFIvPS1{MDFOwG0> M1XM[lI1KGkEoB?= NYnoOWE1UUN3ME21JO69VSxiZYjobYJqfHNic4Tyc45oKGGwdHmtdJJwdGmoZYLheIl3\SCnZn\lZ5R{KGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoVz NFizPWczOzR2M{C4Oi=>
SP6.5 MUHBdI9xfG:|aYOgRZN{[Xl? NUjid3V2PSEQvF2= M3r4clI1KGkEoB?= MkHMbY5lfWOnczDhdI9xfG:|aYRCpC=> NIXJS4wzOzR2M{C4Oi=>
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OCM1 NYL5fFR4SXCxcITvd4l{KEG|c3H5 MkLmOUDPxE1? MmTtNlQhcMLi NGq1fHZqdmS3Y3XzJIFxd3C2b4Ppd:Kh M1zqR|I{PDR|MEi2
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SP6.5 MV3GeY5kfGmxbjDBd5NigQ>? M2mxU|Uh|ryP MoX5NVIhcA>? M2jad5Jm\HWlZYOgeIhmKG2rZ4LheIlwdsLi NHf0PIUzOzR2M{C4Oi=>
VUP NXL6XIdZTnWwY4Tpc44hSXO|YYm= NY\mfnhQPSEQvF2= M1PndVEzKGh? NFvhUGVz\WS3Y3XzJJRp\SCvaXfyZZRqd28EoB?= NYHFUGlrOjN2NEOwPFY>
OCM1 NXXmSnFZTnWwY4Tpc44hSXO|YYm= MnzROUDPxE1? M3vuSFEzKGh? M{DPU5Jm\HWlZYOgeIhmKG2rZ4LheIlwdsLi MmTQNlM1PDNyOE[=
OM431 M2mwWWZ2dmO2aX;uJGF{e2G7 NU\xSJB7PSEQvF2= MV2xNkBp NIrXcYJz\WS3Y3XzJJRp\SCvaXfyZZRqd28EoB?= MWWyN|Q1OzB6Nh?=
HBL-1  NWXLeY5ZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2W4PVPDqM7:TR?= NYrO[I5qOjRxNEivO|IhcA>? NHj3fW1FVVOR MV3zcI94eyClZXzsJIdzd3e2aDDtc4Rme3SueR?= NFXneVMzOzR2MUezNC=>
RAW 264.7 MWLGeY5kfGmxbjDBd5NigQ>? NHrZOFkzNTF3IN88US=> NETPb5IyKGh? NHLtO41FVVOR M{j0TpN2eHC{ZYPz[ZMhfGinIHHjeIl3[XSrb36gc4YhUUuNIH\hcYltgSCvZX3i[ZJ{ NIC0dXozOzR2MUezNC=>
IL-1R  MYnGeY5kfGmxbjDBd5NigQ>? MnLQNk0yPSEQvF2= NHP0WGEyKGh? MlLzSG1UVw>? NWjxfZpHe3WycILld5NmeyC2aHWgZYN1cX[jdHnvckBw\iCLS1ug[oFucWy7IH3lcYJmenN? MUGyN|Q1OTd|MB?=
RAW 264.7 NUHTdW8{TnWwY4Tpc44hSXO|YYm= M37pWlE2KM7:TR?= MW[xJIg> MXnEUXNQ NWfoc4lFe3WycILld5NmeyC2aHWgZYN1cX[jdHnvckBw\iCjbnSgTm5M NFPFT2czOzR2MUezNC=>
IL-1R  MWfGeY5kfGmxbjDBd5NigQ>? NWrHO49EOTVizszN NI\P[|UyKGh? MWDEUXNQ NVTp[XJve3WycILld5NmeyC2aHWgZYN1cX[jdHnvckBw\iCjbnSgTm5M Ml3VNlM1PDF5M{C=
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MT‐1  NFnnXlRHfW6ldHnvckBCe3OjeR?= MU[4xsDDvW1? NWLCR3p4OyCq MV7k[YNz\WG|ZYOgeIhmKGyndnXsd{Bw\iCy4pEQV3RCXDNiYX7kJJDjiJB2RVLQNS=> NVHlXFU2OjN{N{i0O|k>
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MT‐1  MofYSpVv[3Srb36gRZN{[Xl? M2\KbVjDqML3bR?= NV60cmd4OyCq NU\FW2Nz\GWlcnXhd4V{KHSqZTDs[ZZmdHNib3[geIhmKHB4NTDzeYJ2dmm2IH;mJG5H6oDSzsrCxsA> MYWyN|I4QDR5OR?=
MT‐2  NVr2bHp{TnWwY4Tpc44hSXO|YYm= MoPqPOKhyrWv M1nsN|MhcA>? MWjk[YNz\WG|ZYOgeIhmKGyndnXsd{Bw\iC2aHWgdFY2KHO3YoXubZQhd2ZiTldihLDPwkMEoB?= MWSyN|I4QDR5OR?=
MCF-7  MVvGeY5kfGmxbjDBd5NigQ>? Mon1Nk42NTF3IN88US=> NXTRdGZROC53IHi= MlmwSG1UVw>? NICzOG5k[XW|ZYOgeIhmKGe{YXT1ZYwhdG:|czDv[kBk\WyuIHHkbIV{cW:w M{\ZZVI{ODl|MkK3
HaCaT  NEPOUJhHfW6ldHnvckBCe3OjeR?= NX3TdVRmPS5ywrFOwG0> NX3ufYpTOcLiaNMg M3LJXoF1fGWwdXH0[ZMhfGinIGTDU2gucW6mdXPl[EBxem:mdXP0bY9vKG:oIFnMMVbDqA>? MmPhNlMxPDFzNki=
A549  NIfHXmdHfW6ldHnvckBCe3OjeR?= MmjONUBp NVzEe4t4cW6qaXLpeJMhVFSDLXnu[JVk\WRiU2CtRUBuWk6DIIDyc4R2[3Srb39CpJNq\26rZnnjZY51dHl? M3TTeFI{ODNzMkGz
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RAW264.7 MkXXSpVv[3Srb36gRZN{[Xl? NFrtRmsyPSEQvF2= M3z1clE2NTF{MDDtbY4> NES4ZYxjdG:la4OgeIhmKHC{b3T1Z5Rqd25ib3[gUm8tKFCJRUKsJIFv\CCWTl[t{tE> Mn2wNlI4PDV3MkO=
RAW264.7 NF:wb2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\Dclc2NTNyIN88US=> MYeyOEBp MYjpcohq[mm2czDj[YxtKGe{b4f0bEBqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7ldi=> NFzUNpYzOjd2NUWyNy=>
HBL6 MWrBdI9xfG:|aYOgRZN{[Xl? M4T2elAvPS93L{K1JO69VQ>? M{fOPFYwOjRiaB?= M4S1fYRm[3KnYYPld{Bk\WyuII\pZYJqdGm2eTDhcoQhdGWnYXTzJJRwKGGyb4D0c5NqeyCrbjDhJIRwe2VvZHXw[Y5l\W62IH3hco5mesLi M2P5RlIzODd2OEKw
HT29  NEX0c2hHfW6ldHnvckBCe3OjeR?= NVz3[nBUOS1zMDFOwG0> MkXDNVDDqGh? Mn;2bY5kemWjc3XzJGhQNTFibWLORUBidmRicILveIVqdiCneIDy[ZN{cW:w M3fRclIyPjJyOU[0
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K562 NXq0bHB7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF3DPW0zNTNyIN88US=> Mn6xNlQhcA>? NGTvUXVKSzVyPUig{txONGmwaHnibZR{KGOnbHyg[5Jwf3SqIHnuJIEh\G:|ZT3k[ZBmdmSnboSgcYFvdmW{ MlTZNVk3PDZ6MEe=
Jurket NIPVNXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LrOFIuOzBizszN Mk\LNlQhcA>? MWPJR|UxRTdwMTFOwG0tKGmwaHnibZR{KGOnbHyg[5Jwf3SqIHnuJIEh\G:|ZT3k[ZBmdmSnboSgcYFvdmW{ NE\ZXpIyQTZ2NkiwOy=>
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PBMC NVn6TXE2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFjTd40zNTNyIN88US=> NHXtZWEzPCCq NFjJWmtKSzVyPUSwMlIh|ryPLDDpcohq[mm2czDj[YxtKGe{b4f0bEBqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7ldi=> MYmxPVY1PjhyNx?=
K562 M3vXV2Fxd3C2b4Ppd{BCe3OjeR?= M{LIV|IuOjEEoN88UeKh NXvLOGlnOjRiaB?= MWfpcoR2[2W|IHGg[I9{\S2mZYDlcoRmdnRiYYDvdJRwe2m| NV;tell3OTl4NE[4NFc>

... Click to View More Cell Line Experimental Data

Protocol

Cell Research:[2]
+ Expand
  • Cell lines: NCI-H1703 cells
  • Concentrations: ~8 μM
  • Incubation Time: 12 hours
  • Method: Cells are transfected with siRNA in 96-well microtiter plates and then cultured for 72 hours in complete NSCLC medium, treated with BAY 11-7082 for 12 hours. Cells are incubated with [3H]thymidine for 3 hours. The cells are collected on filters using an automatic cell harvester and radioactivity on the filters is measured by β-scintillation counting.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 41 mg/mL (197.82 mM)
Ethanol 10 mg/mL (48.25 mM)
Water Insoluble
In vivo Add solvents individually and in order:
5% DMSO+corn oil
8mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 207.25
Formula

C10H9NO2S

CAS No. 19542-67-7
Storage powder
Synonyms BAY 11-7821

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID