BAY 11-7082

Catalog No.S2913 Synonyms: BAY 11-7821

BAY 11-7082 Chemical Structure

Molecular Weight(MW): 207.25

BAY 11-7082 is a NF-κB inhibitor, inhibits TNFα-induced IκBα phosphorylation with IC50 of 10 μM in tumor cells. Also inhibiting components of the ubiquitin system.

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In DMSO USD 120 In stock
USD 90 In stock
USD 270 In stock
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3 Customer Reviews

  • Immunofluorescence images of Ishikawa cells showing the increase in the nuclear colocalization of ERa (red) and p65 (green) after E2 incubation. Nuclear colocalization is yellow. Treatment with ICI 182,780, PDTC or Bay inhibited the nuclear localization of both ERa and p65. Blue, DAPI-stained nuclei. All pictures were obtained the same day using the same microscope settings. Original magnification 3200, bar =50 um. Arrows, cytoplasmic ERa and p65 staining. ICI, ICI 182,780; Bay, Bay 11-7082.

    Int J Cancer 2014 135(2), 282-94. BAY 11-7082 purchased from Selleck.

    Shown are Western blot analysis of Wnt5a expression in HDPCs treated with TNF-a (n=3–4). The gene expression level was normalized to GAPDH (n = 3–6). HDPCs were preincubated with pyrrolidinedithiocarbamic acid (PDTC, an NF-κB inhibitor), BAY11-7082 (an NF-κB inhibitor), SP600125 (a JNK inhibitor), SB203580 (a p38 inhibitor), or U0126 (an ERK inhibitor) before treatment with TNF-a.

    J Biol Chem 2014 289(30), 21028-21039. BAY 11-7082 purchased from Selleck.

  • The effect of vaspin on TNF α -induced THP-1 cell adhesion to HAECS measured staining with VibrantDiO® Cell-Labeling Solution. The level of THP-1 cell adhesion to HAECs was measured at 4 hr after treatment with 25 -100 ng/mL vaspin in the presence or absence of 10 ng/mL TNF α . BAY11-7082 (10 uM, S2913, Selleckchem, USA), an inhibitor of NF- κ B, was used as a positive control.

    Cardiovasc Diabetol 2014 13, 41. BAY 11-7082 purchased from Selleck.

Purity & Quality Control

Choose Selective IκB/IKK Inhibitors

Biological Activity

Description BAY 11-7082 is a NF-κB inhibitor, inhibits TNFα-induced IκBα phosphorylation with IC50 of 10 μM in tumor cells. Also inhibiting components of the ubiquitin system.
Targets
E2-conjugating enzymes [6]
(Cell-free assay)
IκBα phosphorylation [1]
(Tumor cells)
10 μM
In vitro

BAY 11-7082 completely and specifically abrogates NF-κB DNA binding, downregulating the NF-κB-inducible cytokine IL-6 and inducing apoptosis. [1] BAY 11-7082 (< 8 μM) is able to effectively inhibit both basal and TNFα stimulated NFκB luciferase activity in a dose dependent manner. BAY 11-7082 (8 μM) strongly inhibits the rate of proliferation in NCI-H1703 cells. [2] Bay 11-7082 (5 μM) rapidly and efficiently reduces the DNA binding of NF-kappaB in HTLV-I-infected T-cell lines and down-regulates the expression of the antiapoptotic gene, Bcl-x(L), whereas it has little effect on the DNA binding of another transcription factor, AP-1. Bay 11-7082-induced apoptosis of primary ATL cells is more prominent than that of normal peripheral blood mononuclear cells, and apoptosis of these cells is also associated with down-regulation of NF-kappaB activity. Bay 11-7082 (5 μM) selectively induces apoptosis of HTLV-I–infected T-cell lines associated with down-regulation of the expression of cyclin D1, cyclin D2, and Bcl-xL. [3] BAY 11-7082 (100 μM) prevents the nuclear translocation of p65 elicited by NMDA and the NMDA-induced increase of NF-κB binding in mouse hippocampal slices. BAY 11-7082 prevents NMDA toxicity occurring in CA1 region of hippocampal slices with 40% neuroprotection at 20 μM and 70% neuroprotection at 100 μM. [4] BAY 11-7082 at all concentrations tested significantly inhibits NF-κB p65 DNA-binding activity in adipose tissue, whereas in skeletal muscle, BAY 11-7082 at 50 μM and 100 μM significantly inhibits NF-κB p65 DNA-binding activity. BAY 11-7082 (100 μM) reduces IKK-β protein in human adipose tissue and skeletal muscle. BAY 11-7082 (100 μM) significantly decreases the release of TNF-α from adipose tissue, whereas the release of IL-6 and IL-8 is significantly inhibited at all concentrations of BAY 11-7082 tested. BAY 11-7082 (50 μM) significantly decreases the release of TNF-α, IL-6, and IL-8 in skeletal muscle. [5] BAY 11-7082 is also found to inactivate the E2-conjugating enzymes Ubc (ubiquitin conjugating) 13 and UbcH7 and the E3 ligase LUBAC (linear ubiquitin assembly complex), and thus induces B-cell lymphoma and leukaemic T-cell death. [6]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HeLa MkfaSpVv[3Srb36gRZN{[Xl? MU[xNOKh|ryP MV6xMlUhcA>? NGjxVHhi[m:uaYPo[ZMhSlCDIHnu[JVk\WRidYCgdoVofWyjdHnvckBw\iCITjDhcoQhVU2SLUpCpC=> NEfuemYzPTd7N{SzOy=>
SiHa  MWnGeY5kfGmxbjDBd5NigQ>? MYCxNOKh|ryP M1rW[|EvPSCq Ml[wZYJwdGm|aHXzJGJRSSCrbnT1Z4VlKHWyIILl[5Vt[XSrb36gc4YhTk5iYX7kJG1OWC17wrC= MnjtNlU4QTd2M{e=
ARPE-19 MYLGeY5kfGmxbjDBd5NigQ>? NGH6bJEyKM7:TR?= M37jbVAvPSCq MV3zeZBxemW|c3XzJHRINWmwZIXj[YTDqEmOLUlCpJBzd22xdHXyJIFkfGm4YYTpc44> NV6wd2JGOjV3OUOwNlk>
HCT116 MYjGeY5kfGmxbjDBd5NigQ>? NV7vSYhVPSEQvF2= NYDHcoVVOiCq NUfRb5hbTE2VTx?= NX3xcoFN[XS2ZX71ZZRmeyC|aXz5cYFzcW5vaX7keYNm\CCmb4fudoVofWyjdHnvckBw\iCleXPsbY4hTDF? NWHy[ZpMOjV2N{m3NlM>
HMECs NF3h[4JHfW6ldHnvckBCe3OjeR?= NYPkeG11PcLizszN M1zoXlIhcA>? NELOeWpi[m:uaYPo[ZMhXE6ILd8xMYlv\HWlZXSgWmNCVS1zIHX4dJJme3Orb39CpC=> MXuyOVE6OzFzNh?=
A549  MkfVSpVv[3Srb36gRZN{[Xl? MlTVNVDjiIoEtV2= NH23OpEyOiCq M{W5eJN2eHC{ZYPz[ZMhTH[uLUOgbY5lfWOnZDDhZ5RqfmG2aX;uJI9nKHB4NR?= NIe0XYMzPTF3NkiwNC=>
RAW 264.7 NWrEXHFWTnWwY4Tpc44hSXO|YYm= MWC1xsDPxE1? MojpNUBp NIXTbGpqdmirYnn0d{BVVkZvzsGgZY5lKEmOLUGyJJA1OCCycn;keYN1cW:w NI\Te|UzPTBzOUW2Oy=>
macrophages MkXySpVv[3Srb36gRZN{[Xl? M13Ud|UhyrWP NFXPfog{KGh? M1;IbpBienSrYXzsfUBjdG:la4OgXXBHWy2rbnT1Z4VlKGW6cILld5Nqd25ib3[gbW5QWyCjbnSgR29ZNTMEoB?= M4W5WVI1QTZ5OEm4
HUVECs M1f2TWZ2dmO2aX;uJGF{e2G7 NXfIXGtDOy1|MDFOwG0> NUHmPWZCOSCq NEPQXXdz\WS3Y3XzJJRp\SCneIDy[ZN{cW:wIH;mJI1qWi1zNE\hJIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnXy NFXWTVIzPDh4M{m2OS=>
HeLa  MlPYSpVv[3Srb36gRZN{[Xl? NHPtfYM2yqEQvF2= MXWyOEBp M2P6cGROW09? NGXSTG1z\WS3Y3XzJJRp\SCjY4Tpeol1gSCxZjDUUmYu|rFicILvcY91\XMEoB?= NXrCXII2OjR4NUe3PFM>
A549 NFXmflhHfW6ldHnvckBCe3OjeR?= MYCxNEDPxE1? M4O5fVHjiImq NUfzflRpcW6qaXLpeJMhfGinIHnuZ5Jm[XOnIH;mJJBpd3OyaH:tTe67Ss7zIHnuJHBCOTB|LXnu[oVkfGWmIHP1cJR2emW|wrC= NFXxNIkzPDZzMkS4PC=>
HUVEC NEntcVVHfW6ldHnvckBCe3OjeR?= M1uwcVIxKML3TR?= NHj5ZpoxNjViaB?= MX7EUXNQ NEnSU4txemW4ZX70d{B1cGViaX7keYN1cW:wIH;mJGVCVSCneIDy[ZN{cW:w NWrZ[Hc1OjR3NUGyNFk>
A549RT-eto NInrNXZCeG:ydH;zbZMhSXO|YYm= NGjDOHQyOMLizszN NWHnRWV{OjRiaB?= MXrEUXNQ MYXhZ4NmdGW{YYTld{BHTVKRLX3l[IlifGWmIHHwc5B1d3Orcx?= NV3aVZkxOjR3M{WwPFM>
THP-1  MVrGeY5kfGmxbjDBd5NigQ>? M4ntWFAvOS9zwrFOwG0> MlHDNE42KGh? Ml3PZYJzd2ejdHXzJHRPTi4QsTDz[YNz\XSrb36gZZMhf2WubDDhd{B1cGViaX7jdoVie2WmIIPlZ5JmfGmxbjDv[kBKVC14IHHu[EBKVC1zzsK= M3S5cVI1Ozd6NUO2
SKCXCR2  MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlnINkDDvU1? M125dlQ5KGh? NEG0WZFl\WO{ZXHz[ZMh[2WubDDwdo9tcW[ncnH0bY9vKHOrZ37p[olk[W62bIm= MW[yOFM4Pjd2Nx?=
SKCXCR2  M2fkdGZ2dmO2aX;uJGF{e2G7 NYTOfGFsOiEEtV2= NYO3NZFXPDhiaB?= NET4e4RjdG:la4OgeIhmKEO[Q1yxMYlv\HWlZXSgZ4VtdCCrbo\hd4lwdg>? NVvZU3hzOjR|N{[3OFc>
OVCXCR2 NV;6Z|VCTnWwY4Tpc44hSXO|YYm= NGrlRpozKML3TR?= Mof2OFghcA>? M2DQc4Jtd2OtczD0bIUhS1iFTEGtbY5lfWOnZDDj[YxtKGmwdnHzbY9v MkGyNlQ{PzZ5NEe=
DSCs  NXLa[3NWTnWwY4Tpc44hSXO|YYm= MUOyMlUh|ryP M1\5W|AvPSCq MkHEdoV3\XK|ZYOgeIhmKGWwaHHuZ4Vu\W62IH;mJGNEVDJxQ1PSNkBmgHC{ZYPzbY9vKG:oIFTTR5MhcW6mdXPl[EBjgSCLTD2zNy=> NUnLRZFHOjR|NESyOFA>
WPs MkTqSpVv[3Srb36gRZN{[Xl? MYmyOUDPxE1? M2fEXFUhdWmw Mn\kd5VxeHKnc4Pld{BCXFBiYX7kJJZYTiC|ZXPy[ZRqd25? M1PJdFI1OzNzMkC3
A549RT-eto NHK4NIVCeG:ydH;zbZMhSXO|YYm= Mnf4NVDDqM7:TR?= MnfpNlQhcA>? MWThZ4NmdGW{YYTld{BHOTRiZYj0doFkfC2vZXTpZZRm\CCjcH;weI9{cXNiY3;tZolv\WRidILlZZRu\W62IIfpeIghTjF2 M1rNSVI1OjJyN{K1
A549RT-eto NHuwXYdHfW6ldHnvckBCe3OjeR?= M4rleVExyqEQvF2= MnTlNlQhcA>? NXe2dmRP\GWlcnXhd4V{KHSqZTDlfJBz\XO|aX;uJIxmfmWuczDv[kBPTi4QulKgZY5lKFBvZ4FCpC=> NHjGTJAzPDJ{MEeyOS=>
FaDu NEXpb5BHfW6ldHnvckBCe3OjeR?= M{\XXFIhcA>? MmGzbY5pcWKrdIOgdFY2KGW6cILld5Nqd25iYX7kJIJtd2OtczDUUmbPuS2rbnT1Z4VlKFSZSWPUJIV5eHKnc4Ppc44> M4e3NFI1OjJyNkKy
IVD  MYDGeY5kfGmxbjDBd5NigQ>? NEjGUmgyOMLizszN NXHjN|Q6OyCm MUTy[ZZmenOnczDUUmYu|rIkgKPt[YRq[XSnZDDzeZBxemW|c3nvckBw\iC2aHWg[Il{[yCvYYTybZghdWGlcn;tc4xm[3WuZYOgZYdoemWlYX6gZY5lKGOxbHzh[4VvKEmL M{jtbVI1OTd4OEC4
IVD  NVLTZldDTnWwY4Tpc44hSXO|YYm= NYKyUI5TOTEEoN88US=> NYXifmViOyCm MXXhZpJw\2G2ZYOgWG5HNc7z4pETbY5lfWOnZDD1dE1z\We3bHH0bY9vKG:oIFHERW1VWy12IHHu[EBCTEGPVGOtOeKh NX;QR5hPOjRzN{[4NFg>
iNKT Mnv2SpVv[3Srb36gRZN{[Xl? M{f1UVExNzFyMDFOwG0> M13pWFAvPSCq Mki4bY5pcWKrdIOgeIhmKGmwZIXjeIlwdiCxZjDBNmFTKG2UTlGgZY5lKG:2aHXyJIZi[3Sxch?= NWnYOHc{OjRzMkS0OVM>
PC-3 MXTGeY5kfGmxbjDBd5NigQ>? MXSyMlUwPS9zMDFOwG0> MmLINE42KGh? NHHZSIZjdG:la4OgTWdHNUmLLXnu[JVk\WRiU2TTJI1TVkFiZYjwdoV{e2mxbtMg NYfLbFFCOjRyNUW1NlA>
THP-1  NV;qeZo1TnWwY4Tpc44hSXO|YYm= MWGxNOKh|ryP NV;KPZZMOcLiaB?= MU\hZo9tcXOqZYOgeIhmKGWoZnXjeEBw\iC{SGPQNlchd25iU2KtRUBuWk6D MlK5NlM6Ozl|OUi=
A549 NWn0eXVGTnWwY4Tpc44hSXO|YYm= MYKxxsDPxE1? NXHP[4hjPDhiaB?= NYfkVoNv\W6qYX7j[ZMhfGinIIXwMZJm\3WuYYTpc44hd2ZiSd86RkBidmRic4Xid4VyfWWwdDDk[YNz\WG|ZTDpckBD[XhiZYjwdoV{e2mxbjDpcoR2[2WmIHL5JINwdWKrbnXkJJN1cW23bHH0bY9v MmrSNlM6ODByOEC=
A549 NH\GOo5CeG:ydH;zbZMhSXO|YYm= MXOxxsDPxE1? M3fZbVQ5KGh? NULaWHI4emWmdXPld{B1cGViY3XscEBl\WG2aDDpcoR2[2WmIHL5JINwdWKrbnXkJJN1cW23bHH0bY9v M3HNdFI{QTByMEiw
NCI-N87 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrXdmZjOTBxMkCvN|Ah|ryP NYHteFRqPi9{NDDo M{n3NpN2eHC{ZYPz[ZMh[2WubDD2bYFjcWyrdImgd4lodmmoaXPhcpRtgQ>? Mn7INlM5PDZ3NEW=
AGS NGj1e|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYLU[XVKOTBxMkCvN|Ah|ryP NVXFV2pmPi9{NDDo NUnQZ|A1e3WycILld5NmeyClZXzsJJZq[WKrbHn0fUB{cWewaX\pZ4FvfGy7 MWSyN|g1PjV2NR?=
MGC80-3 M2rG[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYjsUllUOTBxMkCvN|Ah|ryP NF7nc5E3NzJ2IHi= NFPRVJl{fXCycnXzd4V{KGOnbHygeoli[mmuaYT5JJNq\26rZnnjZY51dHl? MnvoNlM5PDZ3NEW=
HGC-27  MonFSpVv[3Srb36gRZN{[Xl? NVLQfo01Py53L{G1M|MxKM7:TR?= NY\LWZZ5PiCq MlXGbY5lfWOnczD0bIUh\GWyaH;zdIhwenmuYYTpc44h[W6mIIXwMZJm\3WuYYTpc44hd2ZiSd86Ru6y MU[yN|g1PjV2NR?=
MGC80-3 M3fkcGZ2dmO2aX;uJGF{e2G7 NF;De3U4NjVxMUWvN|Ah|ryP NY\RRZBbPiCq MWnpcoR2[2W|IITo[UBl\XCqb4PwbI9zgWyjdHnvckBidmRidYCtdoVofWyjdHnvckBw\iCLzsrC{tE> NHn3XoEzOzh2NkW0OS=>
HGC-27  NITPNWlCeG:ydH;zbZMhSXO|YYm= NFTZZ|Q4NjVxMUWvN|Ah|ryP Mof4OkBp MlrhbY5lfWOnczDhdI9xfG:|aYOgbY4h[SC2aX3lMUBidmRiZH;z[U1l\XCnbnTlcpQhdWGwbnXy M{C1N|I{QDR4NUS1
HBE  NX;J[FJkTnWwY4Tpc44hSXO|YYm= M1TJUFEx|ryP MmjnN4g> MnjxZYJwdGm|aHXzJJRp\SCrbnPy[YF{\XNib3[gTWwuPiCneIDy[ZN{cW:wIHnu[JVk\WRiYomgR3NG MVWyN|gzPDB6OR?=
HepG2 MlXlSpVv[3Srb36gRZN{[Xl? NHXQWpkxNjNxMT:zJO69VQ>? MX:0PEBp M4XoOJJm\HWlZYOgTWw3NWmwZIXj[YQhWE:QMTDlfJBz\XO|aX;u MUSyN|c6OTh|Mx?=
THP-1 M{fycGZ2dmO2aX;uJGF{e2G7 MXO1JOK2VQ>? M4nCVVEhcA>? MoK1SG1UVw>? NGm5SYhqdmirYnn0d{BOXEJvaX7keYNm\CCQRt86RkBi[3SrdnH0bY9v M4fO[FI{PjN2MkG4
THP-1  NUj3VnU6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYS1JOK2VQ>? M{TGc|QwQCCm NYqwbY1yTE2VTx?= NGXKUlRz\WS3Y3XzJJRp\SC4aXHibYxqfHlib3[gbY51emGlZXzseYxiesLiTWTC M{SxNFI{PjN2MkG4
MDM MmrjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoXFOUDDvU1? MnnJOE85KGR? NUXoR|RRTE2VTx?= NEi1OlVz\WS3Y3XzJJRp\SC4aXHibYxqfHlib3[gbY51emGlZXzseYxiesLiTWTC NWnWXFVCOjN4M{SyNVg>
AM NIXnVGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYe1JOK2VQ>? M2XT[FQwQCCm M4[3fmROW09? M2LvfZJm\HWlZYOgeIhmKH[rYXLpcIl1gSCxZjDpcpRz[WOnbHz1cIFzyqCPVFK= MYSyN|Y{PDJzOB?=
RAW 264  MXzGeY5kfGmxbjDBd5NigQ>? M2jiV|AvOi13INM1US=> NHL5XXg{OC94MD:5NEBucW5? M3:wc4lvcGmkaYTzJJRp\SCyaH;zdIhifGG|ZTDhZ5Rqfmm2eTDv[kBRXFBzQtMg NHrhfpAzOzV5OEOwNi=>
HUVEC NGO2PG5HfW6ldHnvckBCe3OjeR?= MYOxNOKh|ryP NIXLXXUxNjViaB?= M1\5XmROW09? NH;NeFBkd3WwdHXyZYN1\XNidHjlJIxwe3Nib3[gWIlmOiCvUl7B NHfldGczOzV4M{[zNi=>
HT29 NXzuTXd7TnWwY4Tpc44hSXO|YYm= Mlm4NVAwOzBxMUCwJO69VQ>? Mnm2NUBp MmPEbY5pcWKrdHXzJIJwfGhiVGfFRWsucW6mdXPl[EBxOTByIIDyc4Nme3Orbne= NGH0T3UzOzV{N{G1OC=>
HT29 MW\GeY5kfGmxbjDBd5NigQ>? NVexdGFiOTBxM{CvNVAxKM7:TR?= NGH2N4wyKGh? M4jPOIlvcGmkaYTzJHRPTi2rbnT1Z4VlKHCqb4PwbI9zgWyjdHnvckBidmRiZHXndoFl[XSrb36gc4YhUc78Qt8x NIO0VFAzOzV{N{G1OC=>
MM.1S NH\M[3NCeG:ydH;zbZMhSXO|YYm= NYLnS4pNOzBiwsXN M{H5dFMhcA>? MojLbY5lfWOnczDNUUBk\WyuIHTlZZRpKGmwdn;seoV{KG6nY4Lvd4l{ M37ub|I{PTJ5MUW0
KMS-12-BM MUjBdI9xfG:|aYOgRZN{[Xl? MVezNEDDvU1? NH\uSYE{KGh? NX\oTXh1cW6mdXPld{BOVSClZXzsJIRm[XSqIHnueo9tfmW|IH7lZ5Jwe2m| MkDoNlM2OjdzNUS=
BAFs NV;ENmplTnWwY4Tpc44hSXO|YYm= M1HDUFAvPS9zwrFOwG0> MknENlQhcA>? NVHiRpRjcW6qaXLpeJMhXE6IzsGvSGVZKGmwZIXj[YQhS1mSMUnBNeKhfHKjboPjdolxfHN? NELCbogzOzR6NUS1Oy=>
SP6.5 NIj3UYhHfW6ldHnvckBCe3OjeR?= MWG1JO69VQ>? M{L6WlIhcA>? NGfvVI9l\WO{ZXHz[ZPDqHS{YX7zcI9k[XSrb36gc4YheDZ3IHnuJJRp\SCwdXPs[ZV{yqB? MkH6NlM1PDNyOE[=
VUP Mnu4SpVv[3Srb36gRZN{[Xl? M1HZT|Uh|ryP NIDoc2szKGh? MnTP[IVkemWjc3XzxsB1emGwc3zvZ4F1cW:wIH;mJJA3PSCrbjD0bIUhdnWlbHX1d:Kh MUmyN|Q1OzB6Nh?=
OCM1 NGHXfZpHfW6ldHnvckBCe3OjeR?= NYnxeYR{PSEQvF2= MUSyJIg> NUfudHBv\GWlcnXhd4V{yqC2cnHud4xw[2G2aX;uJI9nKHB4NTDpckB1cGViboXjcIV2e8Li NUC3dGpqOjN2NEOwPFY>
OM431 M{HUXGZ2dmO2aX;uJGF{e2G7 MWK1JO69VQ>? NXLBRoJvOiCq NILnZ2Nl\WO{ZXHz[ZPDqHS{YX7zcI9k[XSrb36gc4YheDZ3IHnuJJRp\SCwdXPs[ZV{yqB? M2rxVVI{PDR|MEi2
SP6.5 NUfSXWYzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnHkNk42NTJyIN88US=> Mmn4NlQhcMLi M3fHUGlEPTB;NTFOwG0tKGW6aHnibZR{KHO2cn;u[{BidnSrLYDyc4xq\mW{YYTpeoUh\W[oZXP0d{BqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7ldi=> NULxU5pzOjN2NEOwPFY>
VUP Ml7FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MontNk42NTJyIN88US=> MVyyOEBpyqB? MkHxTWM2OD13IN88UUwh\XiqaXLpeJMhe3S{b37nJIFvfGlvcILvcIln\XKjdHn2[UBm\m[nY4TzJIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnXy MkTsNlM1PDNyOE[=
OCM1 NUXNTFdxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmT0Nk42NTJyIN88US=> NFvXPGYzPCCqwrC= M2S2bGlEPTB;NTFOwG0tKGW6aHnibZR{KHO2cn;u[{BidnSrLYDyc4xq\mW{YYTpeoUh\W[oZXP0d{BqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7ldi=> M3vEOVI{PDR|MEi2
OM431 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MonaNk42NTJyIN88US=> NH3TPG4zPCCqwrC= NFTYU3NKSzVyPUWg{txONCCneHjpZol1eyC|dILvcoch[W62aT3wdo9tcW[ncnH0bZZmKGWoZnXjeJMhcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7u[ZI> NX[5TJpTOjN2NEOwPFY>
SP6.5 NIfOToRCeG:ydH;zbZMhSXO|YYm= MWW1JO69VQ>? MmDVNlQhcMLi MVjpcoR2[2W|IHHwc5B1d3Orc9Mg NF3FdHkzOzR2M{C4Oi=>
VUP NYKxTHE{SXCxcITvd4l{KEG|c3H5 NGm4Rog2KM7:TR?= NHTyd5MzPCCqwrC= MXfpcoR2[2W|IHHwc5B1d3Orc9Mg MknsNlM1PDNyOE[=
OCM1 M3nHdGFxd3C2b4Ppd{BCe3OjeR?= NGPtW|A2KM7:TR?= NGfpT4QzPCCqwrC= NWXpSIhncW6mdXPld{BieG:ydH;zbZPDqA>? NFHXNJAzOzR2M{C4Oi=>
OM431 MkP1RZBweHSxc3nzJGF{e2G7 MX61JO69VQ>? NH;CcoczPCCqwrC= NWHPV3hvcW6mdXPld{BieG:ydH;zbZPDqA>? NH\ZfoUzOzR2M{C4Oi=>
SP6.5 M4DmSmZ2dmO2aX;uJGF{e2G7 MVG1JO69VQ>? M4izVFEzKGh? Mmf3doVlfWOnczD0bIUhdWmpcnH0bY9vyqB? NWPsWJVXOjN2NEOwPFY>
VUP M3fjfGZ2dmO2aX;uJGF{e2G7 MmG3OUDPxE1? NGHSO|gyOiCq NVG1fG9IemWmdXPld{B1cGVibXnndoF1cW:wwrC= NYHKbo5wOjN2NEOwPFY>
OCM1 NUi1dYtOTnWwY4Tpc44hSXO|YYm= M1ro[VUh|ryP MVWxNkBp MV3y[YR2[2W|IITo[UBucWe{YYTpc47DqA>? NVXSTGFNOjN2NEOwPFY>
OM431 NX7pPHVqTnWwY4Tpc44hSXO|YYm= MVG1JO69VQ>? MVuxNkBp MmXZdoVlfWOnczD0bIUhdWmpcnH0bY9vyqB? NFHmboYzOzR2M{C4Oi=>
HBL-1  MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXSN:Kh|ryP MoP0NlQwPDhxN{KgbC=> M2m1VmROW09? NGT4PFB{dG:5czDj[YxtKGe{b4f0bEBud2Snc4TsfS=> NX;TbVJGOjN2NEG3N|A>
RAW 264.7 MYfGeY5kfGmxbjDBd5NigQ>? M1j0Z|IuOTVizszN MkjENUBp NIfqXpRFVVOR NFfiVlh{fXCycnXzd4V{KHSqZTDhZ5RqfmG2aX;uJI9nKEmNSzDmZY1qdHlibXXtZoVzew>? NHXPeYMzOzR2MUezNC=>
IL-1R  MXnGeY5kfGmxbjDBd5NigQ>? MoK5Nk0yPSEQvF2= NVLSU5dxOSCq MWXEUXNQ NHHkbXB{fXCycnXzd4V{KHSqZTDhZ5RqfmG2aX;uJI9nKEmNSzDmZY1qdHlibXXtZoVzew>? NV7LT4dTOjN2NEG3N|A>
RAW 264.7 NXvvVIs3TnWwY4Tpc44hSXO|YYm= M{e3[VE2KM7:TR?= MoLMNUBp NGP2VWdFVVOR NEfHVJl{fXCycnXzd4V{KHSqZTDhZ5RqfmG2aX;uJI9nKGGwZDDKUms> NGDmZowzOzR2MUezNC=>
IL-1R  M1PvU2Z2dmO2aX;uJGF{e2G7 MnjlNVUh|ryP NIrNd3AyKGh? M1TybmROW09? MV;zeZBxemW|c3XzJJRp\SCjY4TpeoF1cW:wIH;mJIFv\CCMTlu= MYOyN|Q1OTd|MB?=
U2OS NVLYSZFyTnWwY4Tpc44hSXO|YYm= MnPvNVUh|ryP M3z5T|EhcA>? NEnKcnpFVVOR NFTycGZxemW4ZX70d{B1cGViTGDTMUBweiCLTD2xMZN1cW23bHH0[YQh\m:{bXH0bY9vKG:oIFu2N{1xXWJiY3jhbY5{yqB? MVGyN|Q1OTd|MB?=
MT‐1  MWLGeY5kfGmxbjDBd5NigQ>? M{[weVjDqML3bR?= NXnkN3VIOyCq NXvyOIhy\GWlcnXhd4V{KHSqZTDs[ZZmdHNib3[gdQKBmFOWQWSzJIFv\CCy4pEQOGVDWDF? MX:yN|I4QDR5OR?=
MT‐2  NV\u[HJ{TnWwY4Tpc44hSXO|YYm= M1TkWFjDqML3bR?= MlnmN{Bp NYPTfZhs\GWlcnXhd4V{KHSqZTDs[ZZmdHNib3[gdQKBmFOWQWSzJIFv\CCy4pEQOGVDWDF? MkjBNlMzPzh2N{m=
MT‐1  NF;UXpRHfW6ldHnvckBCe3OjeR?= MmXPPOKhyrWv MofGN{Bp MW\k[YNz\WG|ZYOgeIhmKGyndnXsd{Bw\iC2aHWgdFY2KHO3YoXubZQhd2ZiTldihLDPwkMEoB?= MlXONlMzPzh2N{m=
MT‐2  MmTPSpVv[3Srb36gRZN{[Xl? Mk\xPOKhyrWv MV:zJIg> NEf5cVZl\WO{ZXHz[ZMhfGinIHzleoVteyCxZjD0bIUheDZ3IIP1ZpVvcXRib3[gUmbjiJEQulNCpC=> M3rEbVI{Ojd6NEe5
MCF-7  NGfvV4lHfW6ldHnvckBCe3OjeR?= MkjLNk42NTF3IN88US=> MlXlNE42KGh? NWTBTnVKTE2VTx?= M3HwXYNifXOnczD0bIUh\3KjZIXhcEBtd3O|IH;mJINmdGxiYXTo[ZNqd25? M1HpblI{ODl|MkK3
HaCaT  MlLKSpVv[3Srb36gRZN{[Xl? MVG1MlDDqM7:TR?= MlXjNeKhcMLi MkHXZZR1\W63YYTld{B1cGViVFPPTE1qdmS3Y3XkJJBzd2S3Y4Tpc44hd2ZiSVytOuKh Mo\sNlMxPDFzNki=
A549  M2r5UmZ2dmO2aX;uJGF{e2G7 NGnad3kyKGh? Mk\GbY5pcWKrdIOgUHRCNWmwZIXj[YQhW1BvQTDtVm5CKHC{b3T1Z5Rqd28EoIPp[45q\mmlYX70cJk> MknUNlMxOzF{MUO=
OA chondrocytes  MYLGeY5kfGmxbjDBd5NigQ>? NYHrfGRJOTBizszN NHLCb5EyKGh? MYficI9kc3NidHjlJGFITS2EU1GtbY5lfWOnZDDn[Y5mN3C{b4TlbY4h\XiycnXzd4lwdiCxZjDHVnA4QCCxcjDDU3guOiBqcEywMlA2MQ>? MVGyNlk5OjJ{OB?=
RAW264.7 MX7GeY5kfGmxbjDBd5NigQ>? Mn\GNVUh|ryP MXWxOU0yOjBibXnu M2HsOYJtd2OtczD0bIUheHKxZIXjeIlwdiCxZjDOU{whWEeHMjygZY5lKFSQRj5OtS=> MlXHNlI4PDV3MkO=
RAW264.7 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1jXO|UuOzBizszN M{jwUlI1KGh? NH:3NlFqdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDhJIRwe2VvZHXw[Y5l\W62IH3hco5meg>? Mk\uNlI4PDV3MkO=
HBL6 MVjBdI9xfG:|aYOgRZN{[Xl? Mk\PNE42NzVxMkWg{txO M1HWUVYwOjRiaB?= NUHKbnJE\GWlcnXhd4V{KGOnbHygeoli[mmuaYT5JIFv\CCuZXXh[JMhfG9iYYDvdJRwe2m|IHnuJIEh\G:|ZT3k[ZBmdmSnboSgcYFvdmW{wrC= NGjuPFMzOjB5NEiyNC=>
HT29  MXzGeY5kfGmxbjDBd5NigQ>? NE\RSmkyNTFyIN88US=> MWexNOKhcA>? M1LwSYlv[3KnYYPld{BJVy1zIH3SUmEh[W6mIIDyc5RmcW5iZYjwdoV{e2mxbh?= MojNNlE3OjB7NkS=
Ca9–22 MX7BdI9xfG:|aYOgRZN{[Xl? MnXtNVDDqM7:TdMg NVPZd25JOSCq NUW5Splx[2:vcHzleIVtgSCrbnjpZol1eyCDTFGtVGRVNWmwZIXj[YQh[XCxcITvd4l{ Ml[zNlEyOzh2OEC=
Ca9–22 Mn7OSpVv[3Srb36gRZN{[Xl? NUW3SmwzOTEEoN88UeKh MWKxJIg> MmfvZ49ueGyndHXsfUBi[nKxZ3H0[ZMhfGinIFHMRU1RTFRvaX7keYNm\CCMTlugZYN1cX[jdHnvci=> MVmyNVE{QDR6MB?=
A-549 NIqz[4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{OwXlExyqEQvF5CpC=> Ml7UNlQwPDhiaB?= M3PVNIlvcGmkaYTzJINmdGxiZ4Lve5RpKGmwIHGgeIlu\S2mZYDlcoRmdnRibXHucoVz MWGyNFg3PjB2Mx?=
AP M1PSNWZ2dmO2aX;uJGF{e2G7 Mn\GOU8yOCEQvF2= MmTpOFghcA>? NIW4RXFld3ewcnXneYxifGW|IITo[UBDSURicILveIVqdiCuZY\lcEBiKGSxc3Wt[IVx\W6mZX70JI1idm6nch?= NIjSblEzODV7Nk[0OS=>
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AP NE\xO|dHfW6ldHnvckBCe3OjeR?= M{fvUlIxKM7:TR?= NUTpSnhCPC96IHi= M2f2S4Rwf26{ZXf1cIF1\XNidHjlJGJCTCCycn;0[YlvKGyndnXsJIEhfGmvZT3k[ZBmdmSnboSgcYFvdmW{ MV[yNFU6PjZ2NR?=
AQ1 MkSwSpVv[3Srb36gRZN{[Xl? M4\EZlIxKM7:TR?= NXu2XIZlPC96IHi= M1LHNoRwf26{ZXf1cIF1\XNidHjlJGJCTCCycn;0[YlvKGyndnXsJIEhfGmvZT3k[ZBmdmSnboSgcYFvdmW{ NUHNXYtGOjB3OU[2OFU>
THP-1 M33SNmZ2dmO2aX;uJGF{e2G7 NH:4TZE2yqEQvF5CpC=> NETGcmYxNjViaB?= M362cIF1fGWwdXH0[ZMhfGinIFzQV{1qdmS3Y3XkJJAuUc78Qt8xJJBzd3SnaX6gZpkhPzJn MYSyNFMxQTdzOB?=
K562 NFPpRW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXjlWmY6Oi1|MDFOwG0> NULWXIVuOjRiaB?= NE\I[Y9KSzVyPUig{txONGmwaHnibZR{KGOnbHyg[5Jwf3SqIHnuJIEh\G:|ZT3k[ZBmdmSnboSgcYFvdmW{ M1P1U|E6PjR4OEC3
Jurket Mn3aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV:yMVMxKM7:TR?= MorNNlQhcA>? M2fac2lEPTB;Nz6xJO69VSxiaX7obYJqfHNiY3XscEBoem:5dHigbY4h[SCmb4PlMYRmeGWwZHXueEBu[W6wZYK= M{nvfVE6PjR4OEC3
U937 M3Hy[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIHZd4czNTNyIN88US=> MnnhNlQhcA>? MWDJR|UxRTFyLkWg{txONCCrbnjpZol1eyClZXzsJIdzd3e2aDDpckBiKGSxc3Wt[IVx\W6mZX70JI1idm6nch?= M3TMTVE6PjR4OEC3
PBMC MlfnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEm0VFIzNTNyIN88US=> MVKyOEBp NIn3doNKSzVyPUSwMlIh|ryPLDDpcohq[mm2czDj[YxtKGe{b4f0bEBqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7ldi=> Ml:zNVk3PDZ6MEe=
K562 NYPmRW9sSXCxcITvd4l{KEG|c3H5 NYnvNFB5Oi1{MNMg{txOyqB? MVSyOEBp MX\pcoR2[2W|IHGg[I9{\S2mZYDlcoRmdnRiYYDvdJRwe2m| MYSxPVY1PjhyNx?=

... Click to View More Cell Line Experimental Data

Protocol

Cell Research:[2]
+ Expand
  • Cell lines: NCI-H1703 cells
  • Concentrations: ~8 μM
  • Incubation Time: 12 hours
  • Method: Cells are transfected with siRNA in 96-well microtiter plates and then cultured for 72 hours in complete NSCLC medium, treated with BAY 11-7082 for 12 hours. Cells are incubated with [3H]thymidine for 3 hours. The cells are collected on filters using an automatic cell harvester and radioactivity on the filters is measured by β-scintillation counting.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 41 mg/mL (197.82 mM)
Ethanol 10 mg/mL (48.25 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order:
5% DMSO+corn oil
For best results, use promptly after mixing.
8mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 207.25
Formula

C10H9NO2S

CAS No. 19542-67-7
Storage powder
Synonyms BAY 11-7821

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID