BAY 11-7082

Catalog No.S2913 Synonyms: BAY 11-7821

BAY 11-7082 Chemical Structure

Molecular Weight(MW): 207.25

BAY 11-7082 is a NF-κB inhibitor, inhibits TNFα-induced IκBα phosphorylation with IC50 of 10 μM in tumor cells. Also inhibiting components of the ubiquitin system.

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In DMSO USD 120 In stock
USD 90 In stock
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3 Customer Reviews

  • Immunofluorescence images of Ishikawa cells showing the increase in the nuclear colocalization of ERa (red) and p65 (green) after E2 incubation. Nuclear colocalization is yellow. Treatment with ICI 182,780, PDTC or Bay inhibited the nuclear localization of both ERa and p65. Blue, DAPI-stained nuclei. All pictures were obtained the same day using the same microscope settings. Original magnification 3200, bar =50 um. Arrows, cytoplasmic ERa and p65 staining. ICI, ICI 182,780; Bay, Bay 11-7082.

    Int J Cancer 2014 135(2), 282-94. BAY 11-7082 purchased from Selleck.

    Shown are Western blot analysis of Wnt5a expression in HDPCs treated with TNF-a (n=3–4). The gene expression level was normalized to GAPDH (n = 3–6). HDPCs were preincubated with pyrrolidinedithiocarbamic acid (PDTC, an NF-κB inhibitor), BAY11-7082 (an NF-κB inhibitor), SP600125 (a JNK inhibitor), SB203580 (a p38 inhibitor), or U0126 (an ERK inhibitor) before treatment with TNF-a.

    J Biol Chem 2014 289(30), 21028-21039. BAY 11-7082 purchased from Selleck.

  • The effect of vaspin on TNF α -induced THP-1 cell adhesion to HAECS measured staining with VibrantDiO® Cell-Labeling Solution. The level of THP-1 cell adhesion to HAECs was measured at 4 hr after treatment with 25 -100 ng/mL vaspin in the presence or absence of 10 ng/mL TNF α . BAY11-7082 (10 uM, S2913, Selleckchem, USA), an inhibitor of NF- κ B, was used as a positive control.

    Cardiovasc Diabetol 2014 13, 41. BAY 11-7082 purchased from Selleck.

Purity & Quality Control

Choose Selective IκB/IKK Inhibitors

Biological Activity

Description BAY 11-7082 is a NF-κB inhibitor, inhibits TNFα-induced IκBα phosphorylation with IC50 of 10 μM in tumor cells. Also inhibiting components of the ubiquitin system.
Targets
E2-conjugating enzymes [6]
(Cell-free assay)
IκBα phosphorylation [1]
(Tumor cells)
10 μM
In vitro

BAY 11-7082 completely and specifically abrogates NF-κB DNA binding, downregulating the NF-κB-inducible cytokine IL-6 and inducing apoptosis. [1] BAY 11-7082 (< 8 μM) is able to effectively inhibit both basal and TNFα stimulated NFκB luciferase activity in a dose dependent manner. BAY 11-7082 (8 μM) strongly inhibits the rate of proliferation in NCI-H1703 cells. [2] Bay 11-7082 (5 μM) rapidly and efficiently reduces the DNA binding of NF-kappaB in HTLV-I-infected T-cell lines and down-regulates the expression of the antiapoptotic gene, Bcl-x(L), whereas it has little effect on the DNA binding of another transcription factor, AP-1. Bay 11-7082-induced apoptosis of primary ATL cells is more prominent than that of normal peripheral blood mononuclear cells, and apoptosis of these cells is also associated with down-regulation of NF-kappaB activity. Bay 11-7082 (5 μM) selectively induces apoptosis of HTLV-I–infected T-cell lines associated with down-regulation of the expression of cyclin D1, cyclin D2, and Bcl-xL. [3] BAY 11-7082 (100 μM) prevents the nuclear translocation of p65 elicited by NMDA and the NMDA-induced increase of NF-κB binding in mouse hippocampal slices. BAY 11-7082 prevents NMDA toxicity occurring in CA1 region of hippocampal slices with 40% neuroprotection at 20 μM and 70% neuroprotection at 100 μM. [4] BAY 11-7082 at all concentrations tested significantly inhibits NF-κB p65 DNA-binding activity in adipose tissue, whereas in skeletal muscle, BAY 11-7082 at 50 μM and 100 μM significantly inhibits NF-κB p65 DNA-binding activity. BAY 11-7082 (100 μM) reduces IKK-β protein in human adipose tissue and skeletal muscle. BAY 11-7082 (100 μM) significantly decreases the release of TNF-α from adipose tissue, whereas the release of IL-6 and IL-8 is significantly inhibited at all concentrations of BAY 11-7082 tested. BAY 11-7082 (50 μM) significantly decreases the release of TNF-α, IL-6, and IL-8 in skeletal muscle. [5] BAY 11-7082 is also found to inactivate the E2-conjugating enzymes Ubc (ubiquitin conjugating) 13 and UbcH7 and the E3 ligase LUBAC (linear ubiquitin assembly complex), and thus induces B-cell lymphoma and leukaemic T-cell death. [6]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HeLa NX3QVpV4TnWwY4Tpc44hSXO|YYm= NHXnSXMyOMLizszN NF;TdI8yNjViaB?= NWn2dYo1[WKxbHnzbIV{KEKSQTDpcoR2[2WmIIXwJJJm\3WuYYTpc44hd2ZiRl6gZY5lKE2PUD25xsA> NYTsWW02OjV5OUe0N|c>
SiHa  NXOw[mpiTnWwY4Tpc44hSXO|YYm= MlrjNVDDqM7:TR?= MmnrNU42KGh? MULhZo9tcXOqZYOgRnBCKGmwZIXj[YQhfXBicnXneYxifGmxbjDv[kBHViCjbnSgUW1RNToEoB?= MoHSNlU4QTd2M{e=
ARPE-19 NYTJdIJCTnWwY4Tpc44hSXO|YYm= NF;RWmsyKM7:TR?= NUfxN|ZVOC53IHi= M1Ti[JN2eHC{ZYPz[ZMhXEdvaX7keYNm\MLiSVytPOKheHKxbX;0[ZIh[WO2aY\heIlwdg>? NWK2c5NYOjV3OUOwNlk>
HCT116 M1z4WWZ2dmO2aX;uJGF{e2G7 NYrUS4o2PSEQvF2= M3XoO|IhcA>? MoDUSG1UVw>? M1rXdoF1fGWwdXH0[ZMhe2mueX3hdolvNWmwZIXj[YQh\G:5boLl[5Vt[XSrb36gc4Yh[3mlbHnuJGQy MWmyOVQ4QTd{Mx?=
HMECs NGK5VIhHfW6ldHnvckBCe3OjeR?= NY\TfpFTPcLizszN NV;hU5I{OiCq MULhZo9tcXOqZYOgWG5HNc7zLXnu[JVk\WRiVlPBUU0yKGW6cILld5Nqd28EoB?= M4ewWVI2OTl|MUG2
A549  Mk\kSpVv[3Srb36gRZN{[Xl? NUT2U3U{OTEkgJpCuW0> M1;qXVEzKGh? NHz3S5R{fXCycnXzd4V{KES4bD2zJIlv\HWlZXSgZYN1cX[jdHnvckBw\iCyNkW= NHKzV5czPTF3NkiwNC=>
RAW 264.7 M2rPcGZ2dmO2aX;uJGF{e2G7 M1\5Z|XDqM7:TR?= MoTvNUBp Mne3bY5pcWKrdIOgWG5HNc7zIHHu[EBKVC1zMjDwOFAheHKxZIXjeIlwdg>? NVXZWFdOOjVyMUm1Olc>
macrophages NXHHU5hzTnWwY4Tpc44hSXO|YYm= NXXaVoVnPSEEtV2= MVWzJIg> M1u0TJBienSrYXzsfUBjdG:la4OgXXBHWy2rbnT1Z4VlKGW6cILld5Nqd25ib3[gbW5QWyCjbnSgR29ZNTMEoB?= MXGyOFk3Pzh7OB?=
HUVECs MX\GeY5kfGmxbjDBd5NigQ>? MoTRN{0{OCEQvF2= NYPTbmR6OSCq Ml[wdoVlfWOnczD0bIUh\XiycnXzd4lwdiCxZjDtbXIuOTR4YTDpckBiKGSxc3Wt[IVx\W6mZX70JI1idm6nch?= M3\kV|I1QDZ|OU[1
HeLa  MWXGeY5kfGmxbjDBd5NigQ>? MWm1xsDPxE1? M3ToXlI1KGh? MVPEUXNQ NECyXVdz\WS3Y3XzJJRp\SCjY4Tpeol1gSCxZjDUUmYu|rFicILvcY91\XMEoB?= NHfnT4IzPDZ3N{e4Ny=>
A549 NEj2U4xHfW6ldHnvckBCe3OjeR?= MmrRNVAh|ryP NYDJfm5SOeLCiXi= NVfzeYxxcW6qaXLpeJMhfGinIHnuZ5Jm[XOnIH;mJJBpd3OyaH:tTe67Ss7zIHnuJHBCOTB|LXnu[oVkfGWmIHP1cJR2emW|wrC= MXmyOFYyOjR6OB?=
HUVEC NHLKdYZHfW6ldHnvckBCe3OjeR?= M37EZlIxKML3TR?= NXPkTGhKOC53IHi= NXfpe3U6TE2VTx?= NI\WT4xxemW4ZX70d{B1cGViaX7keYN1cW:wIH;mJGVCVSCneIDy[ZN{cW:w NGe5bZgzPDV3MUKwPS=>
A549RT-eto M1POS2Fxd3C2b4Ppd{BCe3OjeR?= MofpNVDDqM7:TR?= NFy1UpgzPCCq M1PhbGROW09? NFu0cI1i[2OnbHXyZZRmeyCIRWLPMY1m\GmjdHXkJIFxd3C2b4Ppdy=> MoO0NlQ2OzVyOEO=
THP-1  M3PyVmZ2dmO2aX;uJGF{e2G7 NEX2dYgxNjFxMdMg{txO NEH2blkxNjViaB?= MXHhZpJw\2G2ZYOgWG5HNc7zIIPlZ5JmfGmxbjDhd{B4\WyuIHHzJJRp\SCrbnPy[YF{\WRic3XjdoV1cW:wIH;mJGlNNTZiYX7kJGlNNTIQsh?= M2HmNVI1Ozd6NUO2
SKCXCR2  NX;lT5BqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYmyJOK2VQ>? MnHUOFghcA>? NV\xcZNX\GWlcnXhd4V{KGOnbHygdJJwdGmoZYLheIlwdiC|aXfubYZq[2GwdHz5 NETpUYMzPDN5Nke0Oy=>
SKCXCR2  NYjRZ3NPTnWwY4Tpc44hSXO|YYm= NF;2e5EzKML3TR?= NUjKWJhkPDhiaB?= MojNZoxw[2u|IITo[UBEYEOOMT3pcoR2[2WmIHPlcIwhcW64YYPpc44> M1;MeFI1Ozd4N{S3
OVCXCR2 MlT1SpVv[3Srb36gRZN{[Xl? MWKyJOK2VQ>? NFrocI41QCCq NFnpWoRjdG:la4OgeIhmKEO[Q1yxMYlv\HWlZXSgZ4VtdCCrbo\hd4lwdg>? MXuyOFM4Pjd2Nx?=
DSCs  MXTGeY5kfGmxbjDBd5NigQ>? NHPHWVUzNjVizszN M4\LelAvPSCq M1f1OpJmfmW{c3XzJJRp\SCnbnjhcoNmdWWwdDDv[kBES0x{L1PDVlIh\XiycnXzd4lwdiCxZjDEV2N{KGmwZIXj[YQh[nliSVytN|M> NYDyfoE5OjR|NESyOFA>
WPs NWW0S|JkTnWwY4Tpc44hSXO|YYm= NWXrbGtzOjVizszN MV61JI1qdg>? MWPzeZBxemW|c3XzJGFVWCCjbnSgendHKHOnY4LleIlwdg>? NUO1OY1LOjR|M{GyNFc>
A549RT-eto NV3qc205SXCxcITvd4l{KEG|c3H5 NF7CUo8yOMLizszN NGLlZo8zPCCq NIj2NY1i[2OnbHXyZZRmeyCIMUSg[Zh1emGldD3t[YRq[XSnZDDhdI9xfG:|aYOgZ49u[mmwZXSgeJJm[XSvZX70JJdqfGhiRkG0 MmDuNlQzOjB5MkW=
A549RT-eto NV\kdnJOTnWwY4Tpc44hSXO|YYm= M2LaS|ExyqEQvF2= NUHl[4huOjRiaB?= NWPBfno2\GWlcnXhd4V{KHSqZTDlfJBz\XO|aX;uJIxmfmWuczDv[kBPTi4QulKgZY5lKFBvZ4FCpC=> Ml;CNlQzOjB5MkW=
FaDu M3jOeGZ2dmO2aX;uJGF{e2G7 MWiyJIg> MmfMbY5pcWKrdIOgdFY2KGW6cILld5Nqd25iYX7kJIJtd2OtczDUUmbPuS2rbnT1Z4VlKFSZSWPUJIV5eHKnc4Ppc44> MXSyOFIzODZ{Mh?=
IVD  NVXFUGlsTnWwY4Tpc44hSXO|YYm= MV[xNOKh|ryP NUDJW4xWOyCm M2\WUJJmfmW{c3XzJHRPTi4QsfMAl41m\GmjdHXkJJN2eHC{ZYPzbY9vKG:oIITo[UBlcXOlIH3heJJqgCCvYXPyc41wdGWldXzld{Bi\2e{ZXPhckBidmRiY3;scIFo\W5iSVm= MmroNlQyPzZ6MEi=
IVD  MUHGeY5kfGmxbjDBd5NigQ>? M4nvOVExyqEQvF2= NHHSVmY{KGR? NX[yWohW[WK{b3fheIV{KFSQRj5OtgKBm2mwZIXj[YQhfXBvcnXneYxifGmxbjDv[kBCTEGPVGOtOEBidmRiQVTBUXRUNTYEoB?= NXnvZWs4OjRzN{[4NFg>
iNKT NG\3OotHfW6ldHnvckBCe3OjeR?= MlTwNVAwOTByIN88US=> NGD4R|kxNjViaB?= NXPO[4R4cW6qaXLpeJMhfGinIHnu[JVkfGmxbjDv[kBCOkGUIH3SUmEh[W6mIH;0bIVzKG[jY4Tvdi=> NHe4emYzPDF{NES1Ny=>
PC-3 NXPJT4VSTnWwY4Tpc44hSXO|YYm= NV7FTndnOi53L{WvNVAh|ryP MlvxNE42KGh? M4HrWYJtd2OtczDJS2YuUUlvaX7keYNm\CCVVGOgcXJPSSCneIDy[ZN{cW:wwrC= M{HLPVI1ODV3NUKw
THP-1  NX\Xd2FXTnWwY4Tpc44hSXO|YYm= MVGxNOKh|ryP NFX6NXoyyqCq M2O1d4Fjd2yrc3jld{B1cGViZX\m[YN1KG:oIILIV3AzPyCxbjDTVk1CKG2UTlG= MmTaNlM6Ozl|OUi=
A549 MVzGeY5kfGmxbjDBd5NigQ>? MV2xxsDPxE1? M2C0XlQ5KGh? MVnlcohidmOnczD0bIUhfXBvcnXneYxifGmxbjDv[kBK|rqEIHHu[EB{fWK|ZYH1[Y51KGSnY4LlZZNmKGmwIFLhfEBmgHC{ZYPzbY9vKGmwZIXj[YQh[nliY3;tZolv\WRic4TpcZVt[XSrb36= M{LiU|I{QTByMEiw
A549 NXzySWJvSXCxcITvd4l{KEG|c3H5 MVmxxsDPxE1? MWW0PEBp MYny[YR2[2W|IITo[UBk\WyuIHTlZZRpKGmwZIXj[YQh[nliY3;tZolv\WRic4TpcZVt[XSrb36= M4XRW|I{QTByMEiw
NCI-N87 M1zGbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVPYVm4zOTBxMkCvN|Ah|ryP MkjWOk8zPCCq NXHUNXV6e3WycILld5NmeyClZXzsJJZq[WKrbHn0fUB{cWewaX\pZ4FvfGy7 MnPUNlM5PDZ3NEW=
AGS MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUmxNE8zOC9|MDFOwG0> NWDtdmVvPi9{NDDo MXTzeZBxemW|c3XzJINmdGxidnnhZoltcXS7IIPp[45q\mmlYX70cJk> NIHBWpgzOzh2NkW0OS=>
MGC80-3 M2TiR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF;4PHcyOC9{MD:zNEDPxE1? NGPtNWQ3NzJ2IHi= MUXzeZBxemW|c3XzJINmdGxidnnhZoltcXS7IIPp[45q\mmlYX70cJk> MorrNlM5PDZ3NEW=
HGC-27  MoHwSpVv[3Srb36gRZN{[Xl? M3vW[FcvPS9zNT:zNEDPxE1? MlWxOkBp MlLzbY5lfWOnczD0bIUh\GWyaH;zdIhwenmuYYTpc44h[W6mIIXwMZJm\3WuYYTpc44hd2ZiSd86Ru6y MYCyN|g1PjV2NR?=
MGC80-3 MXHGeY5kfGmxbjDBd5NigQ>? MmjpO{42NzF3L{OwJO69VQ>? M1TCcVYhcA>? Ml3jbY5lfWOnczD0bIUh\GWyaH;zdIhwenmuYYTpc44h[W6mIIXwMZJm\3WuYYTpc44hd2ZiSd86Ru6y MlXJNlM5PDZ3NEW=
HGC-27  NVmzT2ZpSXCxcITvd4l{KEG|c3H5 MlnvO{42NzF3L{OwJO69VQ>? NEHqSGo3KGh? NU[xSXZ{cW6mdXPld{BieG:ydH;zbZMhcW5iYTD0bY1mNSCjbnSg[I9{\S2mZYDlcoRmdnRibXHucoVz NWnMbHJrOjN6NE[1OFU>
HBE  NEnNV4dHfW6ldHnvckBCe3OjeR?= MmfNNVDPxE1? MX[zbC=> NWT5V5NC[WKxbHnzbIV{KHSqZTDpcoNz\WG|ZYOgc4YhUUxvNjDlfJBz\XO|aX;uJIlv\HWlZXSgZpkhS1OH M3mxb|I{QDJ2MEi5
HepG2 NV[1dYN3TnWwY4Tpc44hSXO|YYm= MVywMlMwOS9|IN88US=> MXW0PEBp M3Prd5Jm\HWlZYOgTWw3NWmwZIXj[YQhWE:QMTDlfJBz\XO|aX;u MkjkNlM4QTF6M{O=
THP-1 NW[xW|BKTnWwY4Tpc44hSXO|YYm= NVfUWZc4PSEEtV2= NFn2[IkyKGh? NHi0S3NFVVOR MYLpcohq[mm2czDNWGIucW6mdXPl[EBPTs78QjDhZ5RqfmG2aX;u Mly0NlM3OzR{MUi=
THP-1  M1fHeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3fie|UhyrWP MmfpOE85KGR? MnLmSG1UVw>? NYrMfIdnemWmdXPld{B1cGVidnnhZoltcXS7IH;mJIlvfHKjY3XscJVt[XMEoF3URi=> NEDIeGQzOzZ|NEKxPC=>
MDM MnLUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3TUS|UhyrWP MXi0M|gh\A>? MXPEUXNQ M4fYXJJm\HWlZYOgeIhmKH[rYXLpcIl1gSCxZjDpcpRz[WOnbHz1cIFzyqCPVFK= NWTi[XgzOjN4M{SyNVg>
AM NXK2cnVnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX21JOK2VQ>? NFG2dlc1NzhiZB?= MoHwSG1UVw>? M{TaZ5Jm\HWlZYOgeIhmKH[rYXLpcIl1gSCxZjDpcpRz[WOnbHz1cIFzyqCPVFK= MkThNlM3OzR{MUi=
RAW 264  MoiwSpVv[3Srb36gRZN{[Xl? NH;q[28xNjJvNTFCuW0> MVOzNE83OC97MDDtbY4> M3frcIlvcGmkaYTzJJRp\SCyaH;zdIhifGG|ZTDhZ5Rqfmm2eTDv[kBRXFBzQtMg MlHVNlM2Pzh|MEK=
HUVEC NV\HWJA5TnWwY4Tpc44hSXO|YYm= MVexNOKh|ryP MXiwMlUhcA>? MYXEUXNQ M33PT4NwfW62ZYLhZ5RmeyC2aHWgcI9{eyCxZjDUbYUzKG2UTlG= NGO5bokzOzV4M{[zNi=>
HT29 NUTDUFl1TnWwY4Tpc44hSXO|YYm= NHvkdYEyOC9|MD:xNFAh|ryP MYWxJIg> M2DCdolvcGmkaYTld{Bjd3SqIGTXSWFMNWmwZIXj[YQheDFyMDDwdo9k\XO|aX7n MlvLNlM2OjdzNUS=
HT29 NIO3c2dHfW6ldHnvckBCe3OjeR?= NV7ETlR3OTBxM{CvNVAxKM7:TR?= NV7MT4lsOSCq MVzpcohq[mm2czDUUmYucW6mdXPl[EBxcG:|cHjvdplt[XSrb36gZY5lKGSnZ4Lh[IF1cW:wIH;mJGnPwkMQsR?= MWGyN|UzPzF3NB?=
MM.1S NELacIZCeG:ydH;zbZMhSXO|YYm= M4TKclMxKML3TR?= Ml30N{Bp MXfpcoR2[2W|IF3NJINmdGxiZHXheIghcW64b3z2[ZMhdmWlcn;zbZM> MVSyN|UzPzF3NB?=
KMS-12-BM NV;RcJUxSXCxcITvd4l{KEG|c3H5 M3;PNlMxKML3TR?= Mn7SN{Bp NWnSS4xxcW6mdXPld{BOVSClZXzsJIRm[XSqIHnueo9tfmW|IH7lZ5Jwe2m| M4LONlI{PTJ5MUW0
BAFs NH;Mb|BHfW6ldHnvckBCe3OjeR?= NIrZOXQxNjVxMdMg{txO M33zS|I1KGh? NV;vcXRPcW6qaXLpeJMhXE6IzsGvSGVZKGmwZIXj[YQhS1mSMUnBNeKhfHKjboPjdolxfHN? M3zGNlI{PDh3NEW3
SP6.5 M{nTO2Z2dmO2aX;uJGF{e2G7 MUe1JO69VQ>? M33Ec|IhcA>? MX7k[YNz\WG|ZYRCpJRz[W6|bH;jZZRqd25ib3[gdFY2KGmwIITo[UBvfWOuZYXzxsA> MWiyN|Q1OzB6Nh?=
VUP NEPSSmNHfW6ldHnvckBCe3OjeR?= M4W0NlUh|ryP MVyyJIg> MnS2[IVkemWjc3XzxsB1emGwc3zvZ4F1cW:wIH;mJJA3PSCrbjD0bIUhdnWlbHX1d:Kh NUnmeJA2OjN2NEOwPFY>
OCM1 MV\GeY5kfGmxbjDBd5NigQ>? NGnkTW42KM7:TR?= Mle4NkBp NIjaeZNl\WO{ZXHz[ZPDqHS{YX7zcI9k[XSrb36gc4YheDZ3IHnuJJRp\SCwdXPs[ZV{yqB? NXXoUFltOjN2NEOwPFY>
OM431 M1rKemZ2dmO2aX;uJGF{e2G7 MUi1JO69VQ>? NFT4SY4zKGh? MVLk[YNz\WG|ZYRCpJRz[W6|bH;jZZRqd25ib3[gdFY2KGmwIITo[UBvfWOuZYXzxsA> NHvlWVMzOzR2M{C4Oi=>
SP6.5 NGC5bGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2Hkb|IvPS1{MDFOwG0> NVHVXIo1OjRiaNMg NGLDR5RKSzVyPUWg{txONCCneHjpZol1eyC|dILvcoch[W62aT3wdo9tcW[ncnH0bZZmKGWoZnXjeJMhcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7u[ZI> NVjaW4FkOjN2NEOwPFY>
VUP NV3TboJJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{fXZ|IvPS1{MDFOwG0> MUWyOEBpyqB? NHTpT4dKSzVyPUWg{txONCCneHjpZol1eyC|dILvcoch[W62aT3wdo9tcW[ncnH0bZZmKGWoZnXjeJMhcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7u[ZI> M3riZVI{PDR|MEi2
OCM1 NFnjfppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWDkWWhFOi53LUKwJO69VQ>? MV6yOEBpyqB? MmjZTWM2OD13IN88UUwh\XiqaXLpeJMhe3S{b37nJIFvfGlvcILvcIln\XKjdHn2[UBm\m[nY4TzJIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnXy MlHuNlM1PDNyOE[=
OM431 NUXC[VB2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmXUNk42NTJyIN88US=> NGLy[IwzPCCqwrC= NGXzcnlKSzVyPUWg{txONCCneHjpZol1eyC|dILvcoch[W62aT3wdo9tcW[ncnH0bZZmKGWoZnXjeJMhcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7u[ZI> NIm4bW4zOzR2M{C4Oi=>
SP6.5 M3rQVWFxd3C2b4Ppd{BCe3OjeR?= MX[1JO69VQ>? M4rVd|I1KGkEoB?= M1HxSIlv\HWlZYOgZZBweHSxc3nzxsA> MkHRNlM1PDNyOE[=
VUP NV\sPJNKSXCxcITvd4l{KEG|c3H5 MnHLOUDPxE1? NYTGS3htOjRiaNMg NEDacGtqdmS3Y3XzJIFxd3C2b4Ppd:Kh NXHwWGk6OjN2NEOwPFY>
OCM1 MXPBdI9xfG:|aYOgRZN{[Xl? NITGVGw2KM7:TR?= MXGyOEBpyqB? NYXQXWxQcW6mdXPld{BieG:ydH;zbZPDqA>? M17BT|I{PDR|MEi2
OM431 NXLLOYFYSXCxcITvd4l{KEG|c3H5 NHG3VWw2KM7:TR?= NVTMU3F4OjRiaNMg NVHDS4E6cW6mdXPld{BieG:ydH;zbZPDqA>? NFH0XHEzOzR2M{C4Oi=>
SP6.5 MojtSpVv[3Srb36gRZN{[Xl? MmTSOUDPxE1? NVn1WYhZOTJiaB?= NGTXXZRz\WS3Y3XzJJRp\SCvaXfyZZRqd28EoB?= NH;tZ4szOzR2M{C4Oi=>
VUP NGnTXXpHfW6ldHnvckBCe3OjeR?= NXm5d3dYPSEQvF2= M3LrblEzKGh? M4q3bpJm\HWlZYOgeIhmKG2rZ4LheIlwdsLi NWXhR|FxOjN2NEOwPFY>
OCM1 NGrOZpFHfW6ldHnvckBCe3OjeR?= NGXScYI2KM7:TR?= NGHaUlQyOiCq NY[yNWxGemWmdXPld{B1cGVibXnndoF1cW:wwrC= NXPySo9qOjN2NEOwPFY>
OM431 Mn\GSpVv[3Srb36gRZN{[Xl? NUXBcWVUPSEQvF2= MWGxNkBp NH;WeZpz\WS3Y3XzJJRp\SCvaXfyZZRqd28EoB?= NFzZXpMzOzR2M{C4Oi=>
HBL-1  NGrZXIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUSzVm1FO8LizszN NWm0V4txOjRxNEivO|IhcA>? Mn\qSG1UVw>? M3nYRpNtd3e|IHPlcIwh\3Kxd4ToJI1w\GW|dHz5 MXSyN|Q1OTd|MB?=
RAW 264.7 NF;l[JNHfW6ldHnvckBCe3OjeR?= MmL0Nk0yPSEQvF2= MmD1NUBp MkDqSG1UVw>? NITaTGh{fXCycnXzd4V{KHSqZTDhZ5RqfmG2aX;uJI9nKEmNSzDmZY1qdHlibXXtZoVzew>? M3n3WVI{PDRzN{Ow
IL-1R  MXfGeY5kfGmxbjDBd5NigQ>? NEfuR|QzNTF3IN88US=> NGjqOZoyKGh? NFWwNWJFVVOR NWfiepJGe3WycILld5NmeyC2aHWgZYN1cX[jdHnvckBw\iCLS1ug[oFucWy7IH3lcYJmenN? NE\wWpAzOzR2MUezNC=>
RAW 264.7 NHL1NIVHfW6ldHnvckBCe3OjeR?= NETH[FcyPSEQvF2= MWSxJIg> M3;QWGROW09? MV3zeZBxemW|c3XzJJRp\SCjY4TpeoF1cW:wIH;mJIFv\CCMTlu= NHPXR5kzOzR2MUezNC=>
IL-1R  M2TjUGZ2dmO2aX;uJGF{e2G7 MV6xOUDPxE1? NUHzWGc6OSCq NHOxUVBFVVOR MVLzeZBxemW|c3XzJJRp\SCjY4TpeoF1cW:wIH;mJIFv\CCMTlu= NHv1N2QzOzR2MUezNC=>
U2OS NWLkfZZDTnWwY4Tpc44hSXO|YYm= MWGxOUDPxE1? MVWxJIg> MYrEUXNQ NFvmbJhxemW4ZX70d{B1cGViTGDTMUBweiCLTD2xMZN1cW23bHH0[YQh\m:{bXH0bY9vKG:oIFu2N{1xXWJiY3jhbY5{yqB? NGH5U48zOzR2MUezNC=>
MT‐1  NGn2PWRHfW6ldHnvckBCe3OjeR?= NUXZfYRLQMLiwsXt MVezJIg> M2XqcoRm[3KnYYPld{B1cGVibHX2[Yx{KG:oIIFihLBUXEGWMzDhcoQheOLCkETFRnAy MU[yN|I4QDR5OR?=
MT‐2  MWfGeY5kfGmxbjDBd5NigQ>? MUm4xsDDvW1? Mmn3N{Bp MUXk[YNz\WG|ZYOgeIhmKGyndnXsd{Bw\iCy4pEQV3RCXDNiYX7kJJDjiJB2RVLQNS=> M1jFSFI{Ojd6NEe5
MT‐1  MYLGeY5kfGmxbjDBd5NigQ>? MUS4xsDDvW1? MkTUN{Bp NUnuZox3\GWlcnXhd4V{KHSqZTDs[ZZmdHNib3[geIhmKHB4NTDzeYJ2dmm2IH;mJG5H6oDSzsrCxsA> MlLsNlMzPzh2N{m=
MT‐2  NFnnVnlHfW6ldHnvckBCe3OjeR?= NFn1b4g5yqEEtX2= MUWzJIg> NYXSeIw4\GWlcnXhd4V{KHSqZTDs[ZZmdHNib3[geIhmKHB4NTDzeYJ2dmm2IH;mJG5H6oDSzsrCxsA> MYCyN|I4QDR5OR?=
MCF-7  NGDqcFdHfW6ldHnvckBCe3OjeR?= MXOyMlUuOTVizszN NWr6eIx6OC53IHi= M1jDWGROW09? NE\ZT4hk[XW|ZYOgeIhmKGe{YXT1ZYwhdG:|czDv[kBk\WyuIHHkbIV{cW:w MXuyN|A6OzJ{Nx?=
HaCaT  NUHRNJlTTnWwY4Tpc44hSXO|YYm= NV:yfoxWPS5ywrFOwG0> M3PkV|HDqGkEoB?= NFS4b2difHSnboXheIV{KHSqZTDUR29JNWmwZIXj[YQheHKxZIXjeIlwdiCxZjDJUE03yqB? NIHScpIzOzB2MUG2PC=>
A549  M4LM[mZ2dmO2aX;uJGF{e2G7 NHvCdFgyKGh? NWfjNpZtcW6qaXLpeJMhVFSDLXnu[JVk\WRiU2CtRUBuWk6DIIDyc4R2[3Srb39CpJNq\26rZnnjZY51dHl? Mn7CNlMxOzF{MUO=
OA chondrocytes  Mn\zSpVv[3Srb36gRZN{[Xl? MmLSNVAh|ryP NE\reowyKGh? M{KzfIJtd2OtczD0bIUhSUeHLVLTRU1qdmS3Y3XkJIdmdmVxcILveIVqdiCneIDy[ZN{cW:wIH;mJGdTWDd6IH;yJGNQYC1{IDjwQFAvODVr MmS3NlI6QDJ{Mki=
RAW264.7 MWPGeY5kfGmxbjDBd5NigQ>? MWOxOUDPxE1? MYqxOU0yOjBibXnu Mn\jZoxw[2u|IITo[UBxem:mdXP0bY9vKG:oIF7PMEBRT0V{LDDhcoQhXE6ILd8x NEf1eZUzOjd2NUWyNy=>
RAW264.7 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2[wSFUuOzBizszN MWOyOEBp NUH6dWl{cW6qaXLpeJMh[2WubDDndo94fGhiaX6gZUBld3OnLXTldIVv\GWwdDDtZY5v\XJ? NWTMNJR[OjJ5NEW1NlM>
HBL6 MkHLRZBweHSxc3nzJGF{e2G7 NWH2c5A3OC53L{WvNlUh|ryP NEHJWYc3NzJ2IHi= Mlri[IVkemWjc3XzJINmdGxidnnhZoltcXS7IHHu[EBt\WWjZIOgeI8h[XCxcITvd4l{KGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoVzyqB? Mn7CNlIxPzR6MkC=
HT29  MV\GeY5kfGmxbjDBd5NigQ>? NHTCWWwyNTFyIN88US=> M2r3S|ExyqCq MVnpcoNz\WG|ZYOgTG8uOSCvUl7BJIFv\CCycn;0[YlvKGW6cILld5Nqd25? NI\PNWYzOTZ{MEm2OC=>
Ca9–22 M4LBd2Fxd3C2b4Ppd{BCe3OjeR?= MXmxNOKh|ryPwrC= MYSxJIg> Ml;aZ49ueGyndHXsfUBqdmirYnn0d{BCVEFvUFTUMYlv\HWlZXSgZZBweHSxc3nz NUjqZnV4OjFzM{i0PFA>
Ca9–22 MVHGeY5kfGmxbjDBd5NigQ>? NIDXW3UyOMLizszNxsA> MUOxJIg> M3\KbYNwdXCuZYTlcJkh[WK{b3fheIV{KHSqZTDBUGEuWESWLXnu[JVk\WRiSl7LJIFkfGm4YYTpc44> NYH4UmduOjFzM{i0PFA>
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AP M4\RdGZ2dmO2aX;uJGF{e2G7 MmXUOU8yOCEQvF2= NUjRVGpiPDhiaB?= NFmxTYJld3ewcnXneYxifGW|IITo[UBDSURicILveIVqdiCuZY\lcEBiKGSxc3Wt[IVx\W6mZX70JI1idm6nch?= NYDlcXQzOjB3OU[2OFU>
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AP NU\wV2pYTnWwY4Tpc44hSXO|YYm= NEHJXnUzOCEQvF2= MV20M|ghcA>? NFTSc41ld3ewcnXneYxifGW|IITo[UBDSURicILveIVqdiCuZY\lcEBiKHSrbXWt[IVx\W6mZX70JI1idm6nch?= NVHYTodjOjB3OU[2OFU>
AQ1 NH3DVlJHfW6ldHnvckBCe3OjeR?= NFP4fVUzOCEQvF2= MlHxOE85KGh? Mliz[I94dnKnZ4XsZZRmeyC2aHWgRmFFKHC{b4TlbY4hdGW4ZXygZUB1cW2nLXTldIVv\GWwdDDtZY5v\XJ? MV:yNFU6PjZ2NR?=
THP-1 NV7ycpk6TnWwY4Tpc44hSXO|YYm= MmDtOeKh|ryPwrC= MoL3NE42KGh? MX;heJRmdnWjdHXzJJRp\SCOUGOtbY5lfWOnZDDwMWnPwkMQsTDwdo91\WmwIHL5JFczLQ>? NFTTcmEzODNyOUexPC=>
K562 MmfTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVWyMVMxKM7:TR?= M3v3[FI1KGh? NELxe5lKSzVyPUig{txONGmwaHnibZR{KGOnbHyg[5Jwf3SqIHnuJIEh\G:|ZT3k[ZBmdmSnboSgcYFvdmW{ Ml\INVk3PDZ6MEe=
Jurket MnHvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWSyMVMxKM7:TR?= M2PzWVI1KGh? MYTJR|UxRTdwMTFOwG0tKGmwaHnibZR{KGOnbHyg[5Jwf3SqIHnuJIEh\G:|ZT3k[ZBmdmSnboSgcYFvdmW{ MVyxPVY1PjhyNx?=
U937 MkDUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlrWNk0{OCEQvF2= MWCyOEBp NWfCfnFuUUN3ME2xNE42KM7:TTygbY5pcWKrdIOgZ4VtdCCpcn;3eIghcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7u[ZI> MnS0NVk3PDZ6MEe=
PBMC NES5NFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGD5XFQzNTNyIN88US=> MlHyNlQhcA>? MmTETWM2OD12MD6yJO69VSxiaX7obYJqfHNiY3XscEBoem:5dHigbY4h[SCmb4PlMYRmeGWwZHXueEBu[W6wZYK= M4f2[FE6PjR4OEC3
K562 NGm4XpVCeG:ydH;zbZMhSXO|YYm= MnjHNk0zOMLizszNxsA> Mlr5NlQhcA>? MVXpcoR2[2W|IHGg[I9{\S2mZYDlcoRmdnRiYYDvdJRwe2m| NYXGSpdZOTl4NE[4NFc>

... Click to View More Cell Line Experimental Data

Protocol

Cell Research:[2]
+ Expand
  • Cell lines: NCI-H1703 cells
  • Concentrations: ~8 μM
  • Incubation Time: 12 hours
  • Method: Cells are transfected with siRNA in 96-well microtiter plates and then cultured for 72 hours in complete NSCLC medium, treated with BAY 11-7082 for 12 hours. Cells are incubated with [3H]thymidine for 3 hours. The cells are collected on filters using an automatic cell harvester and radioactivity on the filters is measured by β-scintillation counting.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 41 mg/mL (197.82 mM)
Ethanol 10 mg/mL (48.25 mM)
Water Insoluble
In vivo Add solvents individually and in order:
5% DMSO+corn oil
8mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 207.25
Formula

C10H9NO2S

CAS No. 19542-67-7
Storage powder
Synonyms BAY 11-7821

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID