BAY 11-7082

Catalog No.S2913 Synonyms: BAY 11-7821

BAY 11-7082 Chemical Structure

Molecular Weight(MW): 207.25

BAY 11-7082 is a NF-κB inhibitor, inhibits TNFα-induced IκBα phosphorylation with IC50 of 10 μM in tumor cells. Also inhibiting components of the ubiquitin system.

Size Price Stock Quantity  
In DMSO USD 120 In stock
USD 90 In stock
USD 270 In stock
Bulk Discount

Free Overnight Delivery on orders over $ 500
Next day delivery by 10:00 a.m. Order now.

3 Customer Reviews

  • Immunofluorescence images of Ishikawa cells showing the increase in the nuclear colocalization of ERa (red) and p65 (green) after E2 incubation. Nuclear colocalization is yellow. Treatment with ICI 182,780, PDTC or Bay inhibited the nuclear localization of both ERa and p65. Blue, DAPI-stained nuclei. All pictures were obtained the same day using the same microscope settings. Original magnification 3200, bar =50 um. Arrows, cytoplasmic ERa and p65 staining. ICI, ICI 182,780; Bay, Bay 11-7082.

    Int J Cancer 2014 135(2), 282-94. BAY 11-7082 purchased from Selleck.

    Shown are Western blot analysis of Wnt5a expression in HDPCs treated with TNF-a (n=3–4). The gene expression level was normalized to GAPDH (n = 3–6). HDPCs were preincubated with pyrrolidinedithiocarbamic acid (PDTC, an NF-κB inhibitor), BAY11-7082 (an NF-κB inhibitor), SP600125 (a JNK inhibitor), SB203580 (a p38 inhibitor), or U0126 (an ERK inhibitor) before treatment with TNF-a.

    J Biol Chem 2014 289(30), 21028-21039. BAY 11-7082 purchased from Selleck.

  • The effect of vaspin on TNF α -induced THP-1 cell adhesion to HAECS measured staining with VibrantDiO® Cell-Labeling Solution. The level of THP-1 cell adhesion to HAECs was measured at 4 hr after treatment with 25 -100 ng/mL vaspin in the presence or absence of 10 ng/mL TNF α . BAY11-7082 (10 uM, S2913, Selleckchem, USA), an inhibitor of NF- κ B, was used as a positive control.

    Cardiovasc Diabetol 2014 13, 41. BAY 11-7082 purchased from Selleck.

Purity & Quality Control

Choose Selective IκB/IKK Inhibitors

Biological Activity

Description BAY 11-7082 is a NF-κB inhibitor, inhibits TNFα-induced IκBα phosphorylation with IC50 of 10 μM in tumor cells. Also inhibiting components of the ubiquitin system.
Targets
E2-conjugating enzymes [6]
(Cell-free assay)
IκBα phosphorylation [1]
(Tumor cells)
10 μM
In vitro

BAY 11-7082 completely and specifically abrogates NF-κB DNA binding, downregulating the NF-κB-inducible cytokine IL-6 and inducing apoptosis. [1] BAY 11-7082 (< 8 μM) is able to effectively inhibit both basal and TNFα stimulated NFκB luciferase activity in a dose dependent manner. BAY 11-7082 (8 μM) strongly inhibits the rate of proliferation in NCI-H1703 cells. [2] Bay 11-7082 (5 μM) rapidly and efficiently reduces the DNA binding of NF-kappaB in HTLV-I-infected T-cell lines and down-regulates the expression of the antiapoptotic gene, Bcl-x(L), whereas it has little effect on the DNA binding of another transcription factor, AP-1. Bay 11-7082-induced apoptosis of primary ATL cells is more prominent than that of normal peripheral blood mononuclear cells, and apoptosis of these cells is also associated with down-regulation of NF-kappaB activity. Bay 11-7082 (5 μM) selectively induces apoptosis of HTLV-I–infected T-cell lines associated with down-regulation of the expression of cyclin D1, cyclin D2, and Bcl-xL. [3] BAY 11-7082 (100 μM) prevents the nuclear translocation of p65 elicited by NMDA and the NMDA-induced increase of NF-κB binding in mouse hippocampal slices. BAY 11-7082 prevents NMDA toxicity occurring in CA1 region of hippocampal slices with 40% neuroprotection at 20 μM and 70% neuroprotection at 100 μM. [4] BAY 11-7082 at all concentrations tested significantly inhibits NF-κB p65 DNA-binding activity in adipose tissue, whereas in skeletal muscle, BAY 11-7082 at 50 μM and 100 μM significantly inhibits NF-κB p65 DNA-binding activity. BAY 11-7082 (100 μM) reduces IKK-β protein in human adipose tissue and skeletal muscle. BAY 11-7082 (100 μM) significantly decreases the release of TNF-α from adipose tissue, whereas the release of IL-6 and IL-8 is significantly inhibited at all concentrations of BAY 11-7082 tested. BAY 11-7082 (50 μM) significantly decreases the release of TNF-α, IL-6, and IL-8 in skeletal muscle. [5] BAY 11-7082 is also found to inactivate the E2-conjugating enzymes Ubc (ubiquitin conjugating) 13 and UbcH7 and the E3 ligase LUBAC (linear ubiquitin assembly complex), and thus induces B-cell lymphoma and leukaemic T-cell death. [6]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HeLa NXvyPXhUTnWwY4Tpc44hSXO|YYm= MmDaNVDDqM7:TR?= MkPRNU42KGh? M3PoUYFjd2yrc3jld{BDWEFiaX7keYNm\CC3cDDy[Yd2dGG2aX;uJI9nKE[QIHHu[EBOVVBvOdMg NUDHSWNMOjV5OUe0N|c>
SiHa  MWrGeY5kfGmxbjDBd5NigQ>? MmfPNVDDqM7:TR?= Ml61NU42KGh? M{\OZ4Fjd2yrc3jld{BDWEFiaX7keYNm\CC3cDDy[Yd2dGG2aX;uJI9nKE[QIHHu[EBOVVBvOdMg NHjMeFAzPTd7N{SzOy=>
ARPE-19 NFnMOZNHfW6ldHnvckBCe3OjeR?= NXrOdFZ3OSEQvF2= NIrQNYoxNjViaB?= NV2xd2hWe3WycILld5NmeyCWRz3pcoR2[2WmwrDJUE05yqCycn;tc5RmeiCjY4TpeoF1cW:w NEDQOHUzPTV7M{CyPS=>
HCT116 MX3GeY5kfGmxbjDBd5NigQ>? NGrpRXo2KM7:TR?= MYWyJIg> M4\zNGROW09? NVXGb|Nz[XS2ZX71ZZRmeyC|aXz5cYFzcW5vaX7keYNm\CCmb4fudoVofWyjdHnvckBw\iCleXPsbY4hTDF? MoTDNlU1Pzl5MkO=
HMECs M{HhS2Z2dmO2aX;uJGF{e2G7 MWO1xsDPxE1? MnTsNkBp MXjhZo9tcXOqZYOgWG5HNc7zLXnu[JVk\WRiVlPBUU0yKGW6cILld5Nqd28EoB?= M2TNZlI2OTl|MUG2
A549  M1XLb2Z2dmO2aX;uJGF{e2G7 M{HCd|Ex6oDLwsXN M3nF[FEzKGh? NYjPOHR3e3WycILld5NmeyCGdnytN{BqdmS3Y3XkJIFkfGm4YYTpc44hd2ZicE[1 NGrF[2EzPTF3NkiwNC=>
RAW 264.7 M4nOXWZ2dmO2aX;uJGF{e2G7 NYi2O2J7PcLizszN MXKxJIg> M1rieolvcGmkaYTzJHRPTi4QsTDhcoQhUUxvMUKgdFQxKHC{b3T1Z5Rqd25? MoTGNlUxOTl3Nke=
macrophages MnzySpVv[3Srb36gRZN{[Xl? NIDIN3U2KML3TR?= Mm\QN{Bp M1XOSJBienSrYXzsfUBjdG:la4OgXXBHWy2rbnT1Z4VlKGW6cILld5Nqd25ib3[gbW5QWyCjbnSgR29ZNTMEoB?= M2XDflI1QTZ5OEm4
HUVECs MlvQSpVv[3Srb36gRZN{[Xl? M{CxVFMuOzBizszN MYixJIg> MWjy[YR2[2W|IITo[UBmgHC{ZYPzbY9vKG:oIH3pVk0yPD[jIHnuJIEh\G:|ZT3k[ZBmdmSnboSgcYFvdmW{ MnfKNlQ5PjN7NkW=
HeLa  M{XIOGZ2dmO2aX;uJGF{e2G7 MnrmOeKh|ryP M{LRO|I1KGh? Ml31SG1UVw>? MWPy[YR2[2W|IITo[UBi[3Srdnn0fUBw\iCWTl[t{tEheHKxbX;0[ZLDqA>? NGPuOVQzPDZ3N{e4Ny=>
A549 NVzyNHh5TnWwY4Tpc44hSXO|YYm= NUL5OlhkOTBizszN NHvJU4ky6oDLaB?= NG\zcYFqdmirYnn0d{B1cGViaX7jdoVie2Vib3[gdIhwe3Cqbz3J{tpD|rFiaX6gVGEyODNvaX7m[YN1\WRiY4XseJVz\XQEoB?= MYOyOFYyOjR6OB?=
HUVEC M{KzemZ2dmO2aX;uJGF{e2G7 MVKyNEDDvU1? NYLyUHIyOC53IHi= M3flemROW09? MXrwdoV3\W62czD0bIUhcW6mdXP0bY9vKG:oIFXBUUBmgHC{ZYPzbY9v MkLjNlQ2PTF{MEm=
A549RT-eto NIjVWFlCeG:ydH;zbZMhSXO|YYm= NY\BPIR4OTEEoN88US=> MUiyOEBp MoTFSG1UVw>? NIHBOWdi[2OnbHXyZZRmeyCIRWLPMY1m\GmjdHXkJIFxd3C2b4Ppdy=> NVTqUHNxOjR3M{WwPFM>
THP-1  NGr0NGpHfW6ldHnvckBCe3OjeR?= M3rBPFAvOS9zwrFOwG0> MV6wMlUhcA>? NVnL[nBQ[WK{b3fheIV{KFSQRj5OtUB{\WO{ZYTpc44h[XNid3XscEBieyC2aHWgbY5kemWjc3XkJJNm[3KndHnvckBw\iCLTD22JIFv\CCLTD2x{tI> NELqVZUzPDN5OEWzOi=>
SKCXCR2  M2e1Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF:5fpkzKML3TR?= MmnqOFghcA>? MWHk[YNz\WG|ZYOgZ4VtdCCycn;sbYZmemG2aX;uJJNq\26rZnnjZY51dHl? NIDUVpgzPDN5Nke0Oy=>
SKCXCR2  MX3GeY5kfGmxbjDBd5NigQ>? M4n6[lIhyrWP MW[0PEBp MV7icI9kc3NidHjlJGNZS0xzLXnu[JVk\WRiY3XscEBqdn[jc3nvci=> M4DFe|I1Ozd4N{S3
OVCXCR2 M1rlT2Z2dmO2aX;uJGF{e2G7 MY[yJOK2VQ>? Ml3uOFghcA>? NHLOOFljdG:la4OgeIhmKEO[Q1yxMYlv\HWlZXSgZ4VtdCCrbo\hd4lwdg>? MVWyOFM4Pjd2Nx?=
DSCs  NVj0dpd7TnWwY4Tpc44hSXO|YYm= M3rxU|IvPSEQvF2= NH3Wc3IxNjViaB?= NVfPPZA4emW4ZYLz[ZMhfGinIHXubIFv[2WvZX70JI9nKEOFTEKvR2NTOiCneIDy[ZN{cW:wIH;mJGRUS3NiaX7keYNm\CCkeTDJUE0{Ow>? NVTYXodwOjR|NESyOFA>
WPs NYDyV4pDTnWwY4Tpc44hSXO|YYm= MnfxNlUh|ryP NXvuOVJTPSCvaX6= NHWyXlF{fXCycnXzd4V{KEGWUDDhcoQhfleIIIPlZ5JmfGmxbh?= NI\vUG0zPDN|MUKwOy=>
A549RT-eto MV\BdI9xfG:|aYOgRZN{[Xl? M1TpeVExyqEQvF2= M3yzTVI1KGh? NWTJeGxQ[WOlZXzldoF1\XNiRkG0JIV5fHKjY4StcYVlcWG2ZXSgZZBweHSxc3nzJINwdWKrbnXkJJRz\WG2bXXueEB4cXSqIF[xOC=> M3LZRVI1OjJyN{K1
A549RT-eto M{LySGZ2dmO2aX;uJGF{e2G7 MUOxNOKh|ryP NUXyN5hLOjRiaB?= MlL1[IVkemWjc3XzJJRp\SCneIDy[ZN{cW:wIHzleoVteyCxZjDOSk3PwkJiYX7kJHAu\3EEoB?= MmnqNlQzOjB5MkW=
FaDu NFXSdohHfW6ldHnvckBCe3OjeR?= M{S3U|IhcA>? MknWbY5pcWKrdIOgdFY2KGW6cILld5Nqd25iYX7kJIJtd2OtczDUUmbPuS2rbnT1Z4VlKFSZSWPUJIV5eHKnc4Ppc44> M2fse|I1OjJyNkKy
IVD  MYrGeY5kfGmxbjDBd5NigQ>? NF\1bXUyOMLizszN MUKzJIQ> M3LWOpJmfmW{c3XzJHRPTi4QsfMAl41m\GmjdHXkJJN2eHC{ZYPzbY9vKG:oIITo[UBlcXOlIH3heJJqgCCvYXPyc41wdGWldXzld{Bi\2e{ZXPhckBidmRiY3;scIFo\W5iSVm= NF7WVFkzPDF5NkiwPC=>
IVD  NEL1[3BHfW6ldHnvckBCe3OjeR?= MmTwNVDDqM7:TR?= NE\ET|k{KGR? NX;qZ2Jx[WK{b3fheIV{KFSQRj5OtgKBm2mwZIXj[YQhfXBvcnXneYxifGmxbjDv[kBCTEGPVGOtOEBidmRiQVTBUXRUNTYEoB?= M{DyUFI1OTd4OEC4
iNKT M1P6NGZ2dmO2aX;uJGF{e2G7 M4HtXlExNzFyMDFOwG0> M3Pwd|AvPSCq M1S3ZYlvcGmkaYTzJJRp\SCrbnT1Z5Rqd25ib3[gRVJCWiCvUl7BJIFv\CCxdHjldkBn[WO2b4K= NHzuUFkzPDF{NES1Ny=>
PC-3 NIToWXdHfW6ldHnvckBCe3OjeR?= MV:yMlUwPS9zMDFOwG0> M3foS|AvPSCq NX3DSpdb[myxY3vzJGlITi2LST3pcoR2[2WmIGPUV{BuWk6DIHX4dJJme3Orb39CpC=> MkDJNlQxPTV3MkC=
THP-1  MVXGeY5kfGmxbjDBd5NigQ>? NHHNUWEyOMLizszN NIfXVmUyyqCq MoDyZYJwdGm|aHXzJJRp\SCnZn\lZ5Qhd2ZicljTVFI4KG:wIGPSMWEhdVKQQR?= MVWyN|k{QTN7OB?=
A549 M1TyfmZ2dmO2aX;uJGF{e2G7 NUHFbYlnOcLizszN M4\RTVQ5KGh? Mnnh[Y5p[W6lZYOgeIhmKHWyLYLl[5Vt[XSrb36gc4YhUc78QjDhcoQhe3Wkc3XxeYVvfCCmZXPy[YF{\SCrbjDCZZgh\XiycnXzd4lwdiCrbnT1Z4VlKGK7IHPvcYJqdmWmIIP0bY12dGG2aX;u NXrLN4w{OjN7MECwPFA>
A549 MVzBdI9xfG:|aYOgRZN{[Xl? MYOxxsDPxE1? NGnaNYQ1QCCq NIPhRmdz\WS3Y3XzJJRp\SClZXzsJIRm[XSqIHnu[JVk\WRiYomgZ49u[mmwZXSgd5RqdXWuYYTpc44> M{HC[lI{QTByMEiw
NCI-N87 M4W0[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1zkcVExNzJyL{OwJO69VQ>? MlfpOk8zPCCq M4XvepN2eHC{ZYPz[ZMh[2WubDD2bYFjcWyrdImgd4lodmmoaXPhcpRtgQ>? NVH2cYVVOjN6NE[1OFU>
AGS MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHK2eY8yOC9{MD:zNEDPxE1? MYW2M|I1KGh? NYXMV5p[e3WycILld5NmeyClZXzsJJZq[WKrbHn0fUB{cWewaX\pZ4FvfGy7 NFG5cVMzOzh2NkW0OS=>
MGC80-3 MoThS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnn4NVAwOjBxM{Cg{txO NUjrenpJPi9{NDDo NV[yPIIze3WycILld5NmeyClZXzsJJZq[WKrbHn0fUB{cWewaX\pZ4FvfGy7 NWfSR5prOjN6NE[1OFU>
HGC-27  NWm1R4RYTnWwY4Tpc44hSXO|YYm= NILCXWc4NjVxMUWvN|Ah|ryP NF\FWVY3KGh? M1LzfIlv\HWlZYOgeIhmKGSncHjvd5Bpd3K7bHH0bY9vKGGwZDD1dE1z\We3bHH0bY9vKG:oIFpOvmLPuQ>? M4L6SlI{QDR4NUS1
MGC80-3 NH:yNmxHfW6ldHnvckBCe3OjeR?= NXzSUlVPPy53L{G1M|MxKM7:TR?= MV[2JIg> NWHOOW1EcW6mdXPld{B1cGViZHXwbI9{eGixconsZZRqd25iYX7kJJVxNXKnZ4XsZZRqd25ib3[gTe67Ss7z NXLJWGVQOjN6NE[1OFU>
HGC-27  MY\BdI9xfG:|aYOgRZN{[Xl? NIThXYc4NjVxMUWvN|Ah|ryP MVq2JIg> NEDyXYFqdmS3Y3XzJIFxd3C2b4Ppd{BqdiCjIITpcYUuKGGwZDDkc5NmNWSncHXu[IVvfCCvYX7u[ZI> MUGyN|g1PjV2NR?=
HBE  MmTQSpVv[3Srb36gRZN{[Xl? MWixNO69VQ>? M2W4dFNp MXjhZo9tcXOqZYOgeIhmKGmwY4LlZZNmeyCxZjDJUE03KGW6cILld5Nqd25iaX7keYNm\CCkeTDDV2U> MVeyN|gzPDB6OR?=
HepG2 NUX0VodKTnWwY4Tpc44hSXO|YYm= NF3rdlAxNjNxMT:zJO69VQ>? NV7GNYh{PDhiaB?= NFfkU4Nz\WS3Y3XzJGlNPi2rbnT1Z4VlKFCRTkGg[ZhxemW|c3nvci=> MoTHNlM4QTF6M{O=
THP-1 NYLXSmU1TnWwY4Tpc44hSXO|YYm= NGTXVHA2KML3TR?= Ml3MNUBp NWDLfmFrTE2VTx?= MkLObY5pcWKrdIOgUXRDNWmwZIXj[YQhVkcQulKgZYN1cX[jdHnvci=> MmjONlM3OzR{MUi=
THP-1  M4L2dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFq1VI02KML3TR?= NHvGNo01NzhiZB?= MnuySG1UVw>? MnLLdoVlfWOnczD0bIUhfmmjYnnsbZR6KG:oIHnueJJi[2WubIXsZZLDqE2WQh?= MV2yN|Y{PDJzOB?=
MDM M4T3Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3vnT|UhyrWP M1TaOlQwQCCm NHjyXmFFVVOR MnjCdoVlfWOnczD0bIUhfmmjYnnsbZR6KG:oIHnueJJi[2WubIXsZZLDqE2WQh?= NH\FOYwzOzZ|NEKxPC=>
AM NEjPXJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUP5UFRsPSEEtV2= M2XTfVQwQCCm MYHEUXNQ NWCyXWlGemWmdXPld{B1cGVidnnhZoltcXS7IH;mJIlvfHKjY3XscJVt[XMEoF3URi=> MlvZNlM3OzR{MUi=
RAW 264  NF\1Xo5HfW6ldHnvckBCe3OjeR?= NF3pTGYxNjJvNTFCuW0> M13me|MxNzZyL{mwJI1qdg>? NXzaS5J1cW6qaXLpeJMhfGinIIDoc5NxcGG2YYPlJIFkfGm4aYT5JI9nKFCWUEHCxsA> MkLTNlM2Pzh|MEK=
HUVEC M3zLPGZ2dmO2aX;uJGF{e2G7 M2DVSFExyqEQvF2= NF2zc|gxNjViaB?= MmPDSG1UVw>? MUfjc5VvfGW{YXP0[ZMhfGinIHzvd5Mhd2ZiVHnlNkBuWk6D MXmyN|U3OzZ|Mh?=
HT29 NHvZN2FHfW6ldHnvckBCe3OjeR?= MYOxNE8{OC9zMECg{txO Ml;5NUBp MmDObY5pcWKrdHXzJIJwfGhiVGfFRWsucW6mdXPl[EBxOTByIIDyc4Nme3Orbne= M3\2[lI{PTJ5MUW0
HT29 MU\GeY5kfGmxbjDBd5NigQ>? MV[xNE8{OC9zMECg{txO NWDx[3RKOSCq MVfpcohq[mm2czDUUmYucW6mdXPl[EBxcG:|cHjvdplt[XSrb36gZY5lKGSnZ4Lh[IF1cW:wIH;mJGnPwkMQsR?= NWnuNVlOOjN3MkexOVQ>
MM.1S NXzOcG81SXCxcITvd4l{KEG|c3H5 NXyzXXNrOzBiwsXN MlfhN{Bp MoXGbY5lfWOnczDNUUBk\WyuIHTlZZRpKGmwdn;seoV{KG6nY4Lvd4l{ NF[xPY8zOzV{N{G1OC=>
KMS-12-BM NUn1cmxVSXCxcITvd4l{KEG|c3H5 NWnhcmx1OzBiwsXN NHrQcmg{KGh? M134[olv\HWlZYOgUW0h[2WubDDk[YF1cCCrbo\vcJZmeyCwZXPyc5Nqew>? MlzoNlM2OjdzNUS=
BAFs M{O1UGZ2dmO2aX;uJGF{e2G7 M2H2O|AvPS9zwrFOwG0> MoXFNlQhcA>? MoHzbY5pcWKrdIOgWG5H|rFxRFXYJIlv\HWlZXSgR3lROTmDMdMgeJJidnOlcnnweJM> M3ruSVI{PDh3NEW3
SP6.5 M{f5bGZ2dmO2aX;uJGF{e2G7 MUC1JO69VQ>? NGHiZ2MzKGh? MkDv[IVkemWjc3XzxsB1emGwc3zvZ4F1cW:wIH;mJJA3PSCrbjD0bIUhdnWlbHX1d:Kh MYqyN|Q1OzB6Nh?=
VUP NIPSeZlHfW6ldHnvckBCe3OjeR?= NHrj[5M2KM7:TR?= NYPJNph6OiCq NH\UTG9l\WO{ZXHz[ZPDqHS{YX7zcI9k[XSrb36gc4YheDZ3IHnuJJRp\SCwdXPs[ZV{yqB? NHnmNnkzOzR2M{C4Oi=>
OCM1 M2fkT2Z2dmO2aX;uJGF{e2G7 NW\ETYdGPSEQvF2= NHOwOlczKGh? NY\VVXIx\GWlcnXhd4V{yqC2cnHud4xw[2G2aX;uJI9nKHB4NTDpckB1cGViboXjcIV2e8Li MUeyN|Q1OzB6Nh?=
OM431 M1\aeWZ2dmO2aX;uJGF{e2G7 MYm1JO69VQ>? NFfaVpMzKGh? M1jBU4Rm[3KnYYPld:KhfHKjboPsc4NifGmxbjDv[kBxPjViaX6geIhmKG63Y3zleZPDqA>? NIrOOVIzOzR2M{C4Oi=>
SP6.5 NVeyT5V[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHrqOnIzNjVvMkCg{txO NWrMOIM{OjRiaNMg M3H0O2lEPTB;NTFOwG0tKGW6aHnibZR{KHO2cn;u[{BidnSrLYDyc4xq\mW{YYTpeoUh\W[oZXP0d{BqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7ldi=> NWLwNG1iOjN2NEOwPFY>
VUP M4DkO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFuyclYzNjVvMkCg{txO M2m3bFI1KGkEoB?= M17BeGlEPTB;NTFOwG0tKGW6aHnibZR{KHO2cn;u[{BidnSrLYDyc4xq\mW{YYTpeoUh\W[oZXP0d{BqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7ldi=> NWPrUo5EOjN2NEOwPFY>
OCM1 MoTaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{[0NlIvPS1{MDFOwG0> M361VVI1KGkEoB?= MVnJR|UxRTVizszNMEBmgGirYnn0d{B{fHKxbnegZY51cS2ycn;sbYZmemG2aY\lJIVn\mWldIOgbY4h[SCmb4PlMYRmeGWwZHXueEBu[W6wZYK= NE\4UoQzOzR2M{C4Oi=>
OM431 NH3md29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYCyMlUuOjBizszN Ml6yNlQhcMLi MmLaTWM2OD13IN88UUwh\XiqaXLpeJMhe3S{b37nJIFvfGlvcILvcIln\XKjdHn2[UBm\m[nY4TzJIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnXy NGT0fXYzOzR2M{C4Oi=>
SP6.5 M1\ub2Fxd3C2b4Ppd{BCe3OjeR?= MX21JO69VQ>? M2jVVlI1KGkEoB?= M2jPTolv\HWlZYOgZZBweHSxc3nzxsA> NXfuN|RzOjN2NEOwPFY>
VUP NWCzbJVWSXCxcITvd4l{KEG|c3H5 NFvVVWw2KM7:TR?= MYGyOEBpyqB? M2O5VIlv\HWlZYOgZZBweHSxc3nzxsA> MWKyN|Q1OzB6Nh?=
OCM1 NXHuS4RGSXCxcITvd4l{KEG|c3H5 Mn\tOUDPxE1? NWjTWXo3OjRiaNMg NWG2NYVlcW6mdXPld{BieG:ydH;zbZPDqA>? MlKyNlM1PDNyOE[=
OM431 M4LmOWFxd3C2b4Ppd{BCe3OjeR?= M17JUlUh|ryP MVyyOEBpyqB? NI\GWZhqdmS3Y3XzJIFxd3C2b4Ppd:Kh NG\yOZczOzR2M{C4Oi=>
SP6.5 NVHJfml5TnWwY4Tpc44hSXO|YYm= NUH5[JU6PSEQvF2= NF3od2kyOiCq NY\5VmZKemWmdXPld{B1cGVibXnndoF1cW:wwrC= NF6wb44zOzR2M{C4Oi=>
VUP MUDGeY5kfGmxbjDBd5NigQ>? NYCzS2lzPSEQvF2= M3K4elEzKGh? NYqzNYxGemWmdXPld{B1cGVibXnndoF1cW:wwrC= NIjEN2wzOzR2M{C4Oi=>
OCM1 NFPFco5HfW6ldHnvckBCe3OjeR?= MlPBOUDPxE1? NUnyVY54OTJiaB?= NFv2WoZz\WS3Y3XzJJRp\SCvaXfyZZRqd28EoB?= MY[yN|Q1OzB6Nh?=
OM431 NFLZdpBHfW6ldHnvckBCe3OjeR?= MmK0OUDPxE1? MlHCNVIhcA>? MWry[YR2[2W|IITo[UBucWe{YYTpc47DqA>? NH\rT44zOzR2M{C4Oi=>
HBL-1  NFXBNYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYe1cmM5O8LizszN NWLuUGRlOjRxNEivO|IhcA>? NFLUVXRFVVOR Mk\Ld4xwf3NiY3XscEBoem:5dHigcY9l\XO2bIm= Mny3NlM1PDF5M{C=
RAW 264.7 MWLGeY5kfGmxbjDBd5NigQ>? NH3t[pkzNTF3IN88US=> MmLQNUBp NUT2SpF{TE2VTx?= M1XobpN2eHC{ZYPz[ZMhfGinIHHjeIl3[XSrb36gc4YhUUuNIH\hcYltgSCvZX3i[ZJ{ NVfhbWU2OjN2NEG3N|A>
IL-1R  M1T6fWZ2dmO2aX;uJGF{e2G7 MnTQNk0yPSEQvF2= Mln4NUBp NWjHeWhWTE2VTx?= MnLld5VxeHKnc4Pld{B1cGViYXP0bZZifGmxbjDv[kBKU0tiZnHtbYx6KG2nbXLldpM> MYiyN|Q1OTd|MB?=
RAW 264.7 NYLZTnhUTnWwY4Tpc44hSXO|YYm= M2nT[lE2KM7:TR?= MWGxJIg> MXPEUXNQ M{PUcpN2eHC{ZYPz[ZMhfGinIHHjeIl3[XSrb36gc4Yh[W6mIFrOTy=> MmHVNlM1PDF5M{C=
IL-1R  NW\XN49QTnWwY4Tpc44hSXO|YYm= M4nBU|E2KM7:TR?= NHvqSHYyKGh? MmPPSG1UVw>? Ml6xd5VxeHKnc4Pld{B1cGViYXP0bZZifGmxbjDv[kBidmRiSl7L NEHoR4UzOzR2MUezNC=>
U2OS MWnGeY5kfGmxbjDBd5NigQ>? M1vmd|E2KM7:TR?= NIftR4QyKGh? M37hSWROW09? M{fTU5Bz\X[nboTzJJRp\SCOUGOtJI9zKEmOLUGtd5RqdXWuYYTl[EBnd3KvYYTpc44hd2ZiS{[zMZBW[iClaHHpcpPDqA>? M{fw[|I{PDRzN{Ow
MT‐1  NWHneoZVTnWwY4Tpc44hSXO|YYm= NY\aW5R6QMLiwsXt MYWzJIg> M3rmZoRm[3KnYYPld{B1cGVibHX2[Yx{KG:oIIFihLBUXEGWMzDhcoQheOLCkETFRnAy NXnITlYxOjN{N{i0O|k>
MT‐2  MYLGeY5kfGmxbjDBd5NigQ>? MYS4xsDDvW1? NF7Y[2I{KGh? MoHa[IVkemWjc3XzJJRp\SCuZY\lcJMhd2ZicPMAlHNVSVR|IHHu[EBx6oDSNFXCVFE> NGTVVGozOzJ5OES3PS=>
MT‐1  M4\JNGZ2dmO2aX;uJGF{e2G7 MkfFPOKhyrWv MXSzJIg> NYS5bpFR\GWlcnXhd4V{KHSqZTDs[ZZmdHNib3[geIhmKHB4NTDzeYJ2dmm2IH;mJG5H6oDSzsrCxsA> NU[zTnVZOjN{N{i0O|k>
MT‐2  MYfGeY5kfGmxbjDBd5NigQ>? NWnRRnFZQMLiwsXt MUmzJIg> NIH0eFll\WO{ZXHz[ZMhfGinIHzleoVteyCxZjD0bIUheDZ3IIP1ZpVvcXRib3[gUmbjiJEQulNCpC=> MWqyN|I4QDR5OR?=
MCF-7  MVvGeY5kfGmxbjDBd5NigQ>? NXG5T41bOi53LUG1JO69VQ>? MlHpNE42KGh? NYnhWYFnTE2VTx?= NX\2UGtN[2G3c3XzJJRp\SCpcnHkeYFtKGyxc4Ogc4Yh[2WubDDh[Ihme2mxbh?= NXLSS4x1OjNyOUOyNlc>
HaCaT  NWT5XFhnTnWwY4Tpc44hSXO|YYm= NIT0RoQ2NjEEoN88US=> MljGNeKhcMLi M33VZYF1fGWwdXH0[ZMhfGinIGTDU2gucW6mdXPl[EBxem:mdXP0bY9vKG:oIFnMMVbDqA>? M3PENFI{ODRzMU[4
A549  MWrGeY5kfGmxbjDBd5NigQ>? NX\5WWh5OSCq NELKbmRqdmirYnn0d{BNXEFvaX7keYNm\CCVUD3BJI1TVkFicILv[JVkfGmxbtMgd4lodmmoaXPhcpRtgQ>? M4jLfFI{ODNzMkGz
OA chondrocytes  NHTS[GxHfW6ldHnvckBCe3OjeR?= M4CxO|ExKM7:TR?= NXXZ[pY6OSCq NXrjbWNL[myxY3vzJJRp\SCDR1WtRnNCNWmwZIXj[YQh\2WwZT;wdo91\WmwIHX4dJJme3Orb36gc4YhT1KSN{igc5IhS0:[LUKgLJA9OC5yNTm= M3fN[|IzQTh{MkK4
RAW264.7 MnfTSpVv[3Srb36gRZN{[Xl? NWDZZ41wOTVizszN M2\FWVE2NTF{MDDtbY4> NFuwV2ljdG:la4OgeIhmKHC{b3T1Z5Rqd25ib3[gUm8tKFCJRUKsJIFv\CCWTl[t{tE> MoHHNlI4PDV3MkO=
RAW264.7 NWT0S2dmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1rrVVUuOzBizszN MkSwNlQhcA>? MorIbY5pcWKrdIOgZ4VtdCCpcn;3eIghcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7u[ZI> M2TjPFIzPzR3NUKz
HBL6 M1jHTGFxd3C2b4Ppd{BCe3OjeR?= MlnnNE42NzVxMkWg{txO MoS5Ok8zPCCq NF7qbpRl\WO{ZXHz[ZMh[2WubDD2bYFjcWyrdImgZY5lKGynZXHkd{B1dyCjcH;weI9{cXNiaX6gZUBld3OnLXTldIVv\GWwdDDtZY5v\XMEoB?= MoDVNlIxPzR6MkC=
HT29  NVv6OYpqTnWwY4Tpc44hSXO|YYm= NFLVPZUyNTFyIN88US=> NVnURYJIOTEEoHi= NXnUPHZzcW6lcnXhd4V{KEiRLUGgcXJPSSCjbnSgdJJwfGWrbjDlfJBz\XO|aX;u MVeyNVYzODl4NB?=
Ca9–22 M3LHV2Fxd3C2b4Ppd{BCe3OjeR?= M3TmeVExyqEQvF5CpC=> NH;1UGcyKGh? NGLaO3Fkd22ybHX0[Yx6KGmwaHnibZR{KEGOQT3QSHQucW6mdXPl[EBieG:ydH;zbZM> NV;1OHlROjFzM{i0PFA>
Ca9–22 MV\GeY5kfGmxbjDBd5NigQ>? Mly0NVDDqM7:TdMg M2rOe|EhcA>? M{K4ToNwdXCuZYTlcJkh[WK{b3fheIV{KHSqZTDBUGEuWESWLXnu[JVk\WRiSl7LJIFkfGm4YYTpc44> MWCyNVE{QDR6MB?=
A-549 MojGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH3YN5cyOMLizszNxsA> Ml\CNlQwPDhiaB?= MlXObY5pcWKrdIOgZ4VtdCCpcn;3eIghcW5iYTD0bY1mNWSncHXu[IVvfCCvYX7u[ZI> MYWyNFg3PjB2Mx?=
AP M1jwZ2Z2dmO2aX;uJGF{e2G7 MVe1M|ExKM7:TR?= Mn\vOFghcA>? M1LiSIRwf26{ZXf1cIF1\XNidHjlJGJCTCCycn;0[YlvKGyndnXsJIEh\G:|ZT3k[ZBmdmSnboSgcYFvdmW{ M1vpfFIxPTl4NkS1
AQ1 M2\RUmZ2dmO2aX;uJGF{e2G7 NIXWRZY2NzFyIN88US=> M4frXVQ5KGh? M2CyZ4Rwf26{ZXf1cIF1\XNidHjlJGJCTCCycn;0[YlvKGyndnXsJIEh\G:|ZT3k[ZBmdmSnboSgcYFvdmW{ M{HrVlIxPTl4NkS1
AP MXLGeY5kfGmxbjDBd5NigQ>? NVzJeZN1OjBizszN M{S3WVQwQCCq NG\3S4Nld3ewcnXneYxifGW|IITo[UBDSURicILveIVqdiCuZY\lcEBiKHSrbXWt[IVx\W6mZX70JI1idm6nch?= M4fTZVIxPTl4NkS1
AQ1 M1f0VWZ2dmO2aX;uJGF{e2G7 MmDJNlAh|ryP MXm0M|ghcA>? NIfaPYVld3ewcnXneYxifGW|IITo[UBDSURicILveIVqdiCuZY\lcEBiKHSrbXWt[IVx\W6mZX70JI1idm6nch?= NUDSXotWOjB3OU[2OFU>
THP-1 MV7GeY5kfGmxbjDBd5NigQ>? NHq2XI82yqEQvF5CpC=> MUKwMlUhcA>? NYSzT|ll[XS2ZX71ZZRmeyC2aHWgUHBUNWmwZIXj[YQheC2LzsrC{tEheHKxdHXpckBjgSB5MjW= Mn3FNlA{ODl5MUi=
K562 NHrYZmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUeyMVMxKM7:TR?= M3vPdFI1KGh? M1vsUmlEPTB;ODFOwG0tcW6qaXLpeJMh[2WubDDndo94fGhiaX6gZUBld3OnLXTldIVv\GWwdDDtZY5v\XJ? NFjyTJQyQTZ2NkiwOy=>
Jurket MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYiyMVMxKM7:TR?= NGjwdnkzPCCq M2TVeWlEPTB;Nz6xJO69VSxiaX7obYJqfHNiY3XscEBoem:5dHigbY4h[SCmb4PlMYRmeGWwZHXueEBu[W6wZYK= NUfld4xYOTl4NE[4NFc>
U937 M13BcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3npc|IuOzBizszN NHjaXWMzPCCq M3\r[2lEPTB;MUCuOUDPxE1uIHnubIljcXS|IHPlcIwh\3Kxd4ToJIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnXy MXKxPVY1PjhyNx?=
PBMC NHnNR5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmWwNk0{OCEQvF2= NU\RUlI6OjRiaB?= NY[zNZg{UUN3ME20NE4zKM7:TTygbY5pcWKrdIOgZ4VtdCCpcn;3eIghcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7u[ZI> NHjJcmMyQTZ2NkiwOy=>
K562 NVT1XVBSSXCxcITvd4l{KEG|c3H5 MX2yMVIxyqEQvF5CpC=> MUCyOEBp MWLpcoR2[2W|IHGg[I9{\S2mZYDlcoRmdnRiYYDvdJRwe2m| NX;ob5FNOTl4NE[4NFc>

... Click to View More Cell Line Experimental Data

Protocol

Cell Research:[2]
+ Expand
  • Cell lines: NCI-H1703 cells
  • Concentrations: ~8 μM
  • Incubation Time: 12 hours
  • Method: Cells are transfected with siRNA in 96-well microtiter plates and then cultured for 72 hours in complete NSCLC medium, treated with BAY 11-7082 for 12 hours. Cells are incubated with [3H]thymidine for 3 hours. The cells are collected on filters using an automatic cell harvester and radioactivity on the filters is measured by β-scintillation counting.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 41 mg/mL (197.82 mM)
Ethanol 10 mg/mL (48.25 mM)
Water Insoluble
In vivo Add solvents individually and in order:
5% DMSO+corn oil
8mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 207.25
Formula

C10H9NO2S

CAS No. 19542-67-7
Storage powder
Synonyms BAY 11-7821

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

IκB/IKK Signaling Pathway Map

IκB/IKK Inhibitors with Unique Features

Related IκB/IKK Products

Tags: buy BAY 11-7082 | BAY 11-7082 supplier | purchase BAY 11-7082 | BAY 11-7082 cost | BAY 11-7082 manufacturer | order BAY 11-7082 | BAY 11-7082 distributor
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID