Honokiol

Catalog No.S2310

Honokiol Chemical Structure

Molecular Weight(MW): 266.334

Honokiol is the active principle of magnolia extract that inhibits Akt-phosphorylation and promotes ERK1/2 phosphorylation. Phase 3.

Size Price Stock Quantity  
In DMSO USD 110 In stock
USD 88 In stock
USD 148 In stock
USD 260 In stock
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1 Customer Review

  • (B) Cleaved PARP, Bax and Bcl2 protein expression was evaluated by immunoblotting of KRAS mutant cells lysates after 48 h of honokiol (10, 20, 40, and 60 μM) treatment. ∗∗P < 0.01 and ∗∗∗P < 0.001 for comparison between control group and honokiol-treated group.

    Front Pharmacol, 2017. Honokiol purchased from Selleck.

Purity & Quality Control

Choose Selective Akt Inhibitors

Biological Activity

Description Honokiol is the active principle of magnolia extract that inhibits Akt-phosphorylation and promotes ERK1/2 phosphorylation. Phase 3.
Targets
Akt-phosphorylation [1] MEK [1]
In vitro

Honokiol shows pro-apoptotic effects in melanoma, sarcoma, myeloma, leukemia, bladder, lung, prostate, oral squamous cell carcinoma and colon cancer cell lines. Honokiol is effective on inducing apoptosis in SVR angiosarcoma cells. Treatment of SVR cells with honokiol causes decreased phosphorylation of MAP kinase, akt, and c-src. In addition, honokiol potentiates TRAIL-mediated apoptosis, and honokiol cytotoxicity is partially abrogated by neutralizing antibodies to TRAIL. Honokiol also has direct antiangiogenic activity, in that honokiol blocks the phosphorylation and rac activation due to VEGF-VEGFR2 interactions. [1] Honokiol causes apoptosis in CLL cells through activation of caspase 8, followed by caspase 9 and 3 activation. Honokiol prevents interleukin-4-mediated survival of CLL cells, and potentiats the cytotoxicity of chlorambucil, fludarabine, and cladribine. [3] Honokiol kills myeloma cells from relapsed patients at doses that does not kill PBMCs. Caspase 3, 7, 8, and 9 are induced by honokiol treatment, as well as PARP cleavage. [2] Honokiol is found to induce apoptosis in the colon cancer cell lines RKO. [4] Honokiol potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through modulation of nuclear factor-kappaB activation pathway. [5] Honokiol may act as a potent anti-inflammatory agent with multipotential activities due to an inhibitory effect on the PI3K/Akt pathway. [6]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human UACC-903 cells MWXDfZRwfG:6aXPpeJkh[XO|YYm= MVLDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDVRWNENTlyMzDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSVIHHzd4F6NCCLQ{WwQVUvOSEQvF2= MVeyNlU{Ozl6Mx?=
Vero E6 cells MUfGeY5kfGmxbjDhd5NigQ>? MXvBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDTRXJUKGOxcn;uZZZqenW|IHnuJHZmem9iRU[gZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYLhcEBz\XCuaXPheIlwdiCkeTDFUGlUSSxiRVO1NF03NjVizszN M{S5[lE4PjZ|NUO5
human UACC-903 cells MkGyR5l1d3SxeHnjbZR6KGG|c3H5 MWrDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDVRWNENTlyMzDj[YxteyCjZoTldkAzPCCqcoOgZpkhVVSVIHHzd4F6NCCLQ{WwQVcvPDVizszN NYrxblhNOjJ3M{O5PFM>
human A549 cells M3jqNGN6fG:2b4jpZ4l1gSCjc4PhfS=> NXHYNmNPS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTV2OTDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSVIHHzd4F6NCCLQ{WwQVcvPzVizszN M4myVlIzPTN|OUiz
human CEM cells NHzmNIpEgXSxdH;4bYNqfHliYYPzZZk> MmLvR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gR2VOKGOnbHzzMEBKSzVyPUGwMlkh|ryP M364VFE4PTh5NUey
HEK293 cells NGLudohHfW6ldHnvckBie3OjeR?= MoXjRYdwdmm|dDDhZ5Rqfmm2eTDheEBTYFKjbIDoZUBqdiCKRVuyPVMh[2WubIOgZZN{\XO|ZXSgZZMhfHKjboPjdolxfGmxbnHsJIFkfGm4YYTpc44h[W[2ZYKgOFghcHK|IHL5JIx2[2moZYLhd4UhemWyb4L0[ZIh\2WwZTDhd5NigSxiRVO1NF0yOS56IN88US=> MWCyNFY6PTR5Mh?=
human A549 cell MVfDfZRwfG:6aXPpeJkh[XO|YYm= MVSyOEBp MnjDR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVU1QSClZXzsd{Bi\nSncjCyOEBpenNiYomgUXRUKGG|c3H5MEBKSzVyPUGyMlUyKM7:TR?= NVzRS|E2OjJ3M{O5PFM>
human HT-29 cells NWSwXXlCS3m2b4TvfIlkcXS7IHHzd4F6 MYC3NkBp NWfxR2VwS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUFRvMkmgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WUzDhd5NigSxiSVO1NF0yOy5{NDFOwG0> NGPHcXQzOjV|M{m4Ny=>
human PBM cells Mn3jR5l1d3SxeHnjbZR6KGG|c3H5 NVXaSmR7S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hWEKPIHPlcIx{NCCLQ{WwQVE3NjFizszN MmPvNVc2QDd3N{K=
Hep-G2 cells M3nUUGN6fG:2b4jpZ4l1gSCjc4PhfS=> NX3qboFYS3m2b4TvfIlkcXS7IH;mJINwdXCxdX7kJIFo[Wmwc4SgbJVu[W5ibHn2[ZIhfHWvb4KgZ4VtdCCuaX7lJEhJ\XBvR{KpJJdieyCmZYTldo1qdmWmLDDJR|UxRTF4LkWg{txO M1O3dVE2PTh{NEOy
human HepG2 cells M3rDT3Bzd2yrZnXyZZRqd25iYYPzZZk> M4nsVlI1KGh? NYHLfod1SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bi\nSncjCyOEBpenNiYomgUXRVKGG|c3H5MEBKSzVyPUG2MlUh|ryP NH3BNXYzOTh3M{m5NS=>
human K562 cells MUjQdo9tcW[ncnH0bY9vKGG|c3H5 M3LGO2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iS{W2NkBk\WyuczDifUBOXFRiYYPzZZktKEmFNUC9NlEvOSEQvF2= MnTENVk2QDl4N{i=
Vero cells NX;NRWNvS3m2b4TvfIlkcXS7IHHzd4F6 NYG0Snh7S3m2b4TvfIlkcXS7IHHnZYlve3RiVnXyc{Bk\WyuczygTWM2OD1{Mj61JO69VQ>? NVvrZW9rOTZ5MkK2OlQ>
human A2780 cells M3nIfHBzd2yrZnXyZZRqd25iYYPzZZk> MUfBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHPpd5Bt[XSrbj3z[Y5{cXSrdnWgbJVu[W5iQUK3PFAh[2WubIOgZpkhVVSWIHHzd4F6NCCLQ{WwQVMxNjVizszN MYqxPVU5QTZ5OB?=
human SPC-A1 cells MW\Qdo9tcW[ncnH0bY9vKGG|c3H5 Ml3PRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCVUFOtRVEh[2WubIOgZpkhVVSWIHHzd4F6NCCLQ{WwQVM3NjFizszN MUSxPVU5QTZ5OB?=
HUVEC cells MWfGeY5kfGmxbjDhd5NigQ>? M{jwcFIxKM7:TR?= Mk\LNlQhcA>? NUHUcZZRSW62aX3p[5JifG:{eTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiXVlXDJINmdGy|IHH0JFIxKHWPIHHmeIVzKDJ2IHjyd{BjgSC5b4Xu[E1p\WGuaX7nJIF{e2G7 MUmyNVg2Ozl7MR?=
HEK293 cells Mn7uSpVv[3Srb36gZZN{[Xl? NV;VU4hFOjRvNEigbC=> Mn3FRYdwdmm|dDDhZ5Rqfmm2eTDheEBpfW2jbjDSXHIu[WyyaHGg[ZhxemW|c3XkJIlvKEiHS{K5N{Bk\WyuczDjc4V5eHKnc4Ppcochf2m2aDDwR21ZNWKndHGt[4FtKGGodHXyJFI1KHSxIES4JIhzeyCkeTDseYNq\mW{YYPlJJJmeG:{dHXyJIdmdmViYYPzZZk> MlTjNlQ6PTl7OEe=
human SH-SY5Y cells MYTGeY5kfGmxbjDhd5NigQ>? Mm\wNVAh|ryP MlS4N|AhdWmwcx?= MVTO[ZVzd3C{b4TlZ5RqfmViYXP0bZZqfHliaX6gbJVu[W5iU1itV3k2YSClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJGNJWCCjbnSgWGJJWC2rbnT1Z4VlKGOnbHyg[IVifGhiYYSgNVAhfU1iaX7jeYJifGWmIH\vdkA{OCCvaX7zJJBzcW:{IITvJINp[WyuZX7n[UBu\WG|dYLl[EBi\nSncjCzJIhzeyCkeTDNWHQh[XO|YYm= MVyyNlE1OjV|OR?=

... Click to View More Cell Line Experimental Data

In vivo Honokiol is highly effective against SVR angiosarcoma in nude mice. [1] Honokiol inhibits the growth of RKO cells in murine xenografts. [4] Honokiol prevents the growth of MDA-MD-231 breast cancer cells in murine xenografts. [7]

Protocol

Solubility (25°C)

In vitro DMSO 53 mg/mL (198.99 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 266.334
Formula

C18H18O2

CAS No. 35354-74-6
Storage powder
Synonyms N/A

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID