Honokiol

Catalog No.S2310

Honokiol Chemical Structure

Molecular Weight(MW): 266.334

Honokiol is the active principle of magnolia extract that inhibits Akt-phosphorylation and promotes ERK1/2 phosphorylation. Phase 3.

Size Price Stock Quantity  
In DMSO USD 110 In stock
USD 88 In stock
USD 148 In stock
USD 260 In stock
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  • (B) Cleaved PARP, Bax and Bcl2 protein expression was evaluated by immunoblotting of KRAS mutant cells lysates after 48 h of honokiol (10, 20, 40, and 60 μM) treatment. ∗∗P < 0.01 and ∗∗∗P < 0.001 for comparison between control group and honokiol-treated group.

    Front Pharmacol, 2017, 8:199. Honokiol purchased from Selleck.

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Biological Activity

Description Honokiol is the active principle of magnolia extract that inhibits Akt-phosphorylation and promotes ERK1/2 phosphorylation. Phase 3.
Targets
Akt-phosphorylation [1] MEK [1]
In vitro

Honokiol shows pro-apoptotic effects in melanoma, sarcoma, myeloma, leukemia, bladder, lung, prostate, oral squamous cell carcinoma and colon cancer cell lines. Honokiol is effective on inducing apoptosis in SVR angiosarcoma cells. Treatment of SVR cells with honokiol causes decreased phosphorylation of MAP kinase, akt, and c-src. In addition, honokiol potentiates TRAIL-mediated apoptosis, and honokiol cytotoxicity is partially abrogated by neutralizing antibodies to TRAIL. Honokiol also has direct antiangiogenic activity, in that honokiol blocks the phosphorylation and rac activation due to VEGF-VEGFR2 interactions. [1] Honokiol causes apoptosis in CLL cells through activation of caspase 8, followed by caspase 9 and 3 activation. Honokiol prevents interleukin-4-mediated survival of CLL cells, and potentiats the cytotoxicity of chlorambucil, fludarabine, and cladribine. [3] Honokiol kills myeloma cells from relapsed patients at doses that does not kill PBMCs. Caspase 3, 7, 8, and 9 are induced by honokiol treatment, as well as PARP cleavage. [2] Honokiol is found to induce apoptosis in the colon cancer cell lines RKO. [4] Honokiol potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through modulation of nuclear factor-kappaB activation pathway. [5] Honokiol may act as a potent anti-inflammatory agent with multipotential activities due to an inhibitory effect on the PI3K/Akt pathway. [6]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human UACC-903 cells MUTDfZRwfG:6aXPpeJkh[XO|YYm= NE\BZY5EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBWSUOFLUmwN{Bk\WyuczDh[pRmeiB5MjDodpMh[nliTWTTJIF{e2G7LDDJR|UxRTVwMTFOwG0> M1KxR|IzPTN|OUiz
Vero E6 cells MWDGeY5kfGmxbjDhd5NigQ>? M2[3OWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JHNCWlNiY3;yc45ifmm{dYOgbY4hXmW{bzDFOkBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdoFtKHKncHzpZ4F1cW:wIHL5JGVNUVODLDDFR|UxRTZwNTFOwG0> M1v5VVE4PjZ|NUO5
human UACC-903 cells M1P3fGN6fG:2b4jpZ4l1gSCjc4PhfS=> NYTJS|FYS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hXUGFQz25NFMh[2WubIOgZYZ1\XJiMkSgbJJ{KGK7IF3UV{Bie3OjeTygTWM2OD15LkS1JO69VQ>? MUmyNlU{Ozl6Mx?=
human A549 cells NHTnU3JEgXSxdH;4bYNqfHliYYPzZZk> MWnDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHMh[XO|YYmsJGlEPTB;Nz63OUDPxE1? MWOyNlU{Ozl6Mx?=
human CEM cells Mn[3R5l1d3SxeHnjbZR6KGG|c3H5 M2iwOmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGNGVSClZXzsd{whUUN3ME2xNE46KM7:TR?= NWW4THN5OTd3OEe1O|I>
HEK293 cells NUXCSlhrTnWwY4Tpc44h[XO|YYm= MUnB[49vcXO2IHHjeIl3cXS7IHH0JHJZWmGucHjhJIlvKEiHS{K5N{Bk\WyuczDhd5Nme3OnZDDhd{B1emGwc3PybZB1cW:wYXygZYN1cX[jdHnvckBi\nSncjC0PEBpenNiYomgcJVkcW[ncnHz[UBz\XCxcoTldkBo\W6nIHHzd4F6NCCHQ{WwQVEyNjhizszN NEPk[lUzODZ7NUS3Ni=>
human A549 cell NGfpZZVEgXSxdH;4bYNqfHliYYPzZZk> M1W4V|I1KGh? NInqRW1EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPTR7IHPlcIx{KGGodHXyJFI1KGi{czDifUBOXFNiYYPzZZktKEmFNUC9NVIvPTFizszN NVmyPWRwOjJ3M{O5PFM>
human HT-29 cells M{\hZWN6fG:2b4jpZ4l1gSCjc4PhfS=> MmHlO|IhcA>? MXHDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIWE0zQSClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRUKGG|c3H5MEBKSzVyPUGzMlI1KM7:TR?= NIfBXWczOjV|M{m4Ny=>
human PBM cells NFv5N2NEgXSxdH;4bYNqfHliYYPzZZk> M{HaVGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHBDVSClZXzsd{whUUN3ME2xOk4yKM7:TR?= NHHqbIoyPzV6N{W3Ni=>
Hep-G2 cells M4fUXGN6fG:2b4jpZ4l1gSCjc4PhfS=> NV31b|JbS3m2b4TvfIlkcXS7IH;mJINwdXCxdX7kJIFo[Wmwc4SgbJVu[W5ibHn2[ZIhfHWvb4KgZ4VtdCCuaX7lJEhJ\XBvR{KpJJdieyCmZYTldo1qdmWmLDDJR|UxRTF4LkWg{txO NVHhenNTOTV3OEK0N|I>
human HepG2 cells MUDQdo9tcW[ncnH0bY9vKGG|c3H5 MkHrNlQhcA>? NX;FfJJHSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bi\nSncjCyOEBpenNiYomgUXRVKGG|c3H5MEBKSzVyPUG2MlUh|ryP M4H4W|IyQDV|OUmx
human K562 cells NVLoNGNPWHKxbHnm[ZJifGmxbjDhd5NigQ>? MoK4RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCNNU[yJINmdGy|IHL5JG1VXCCjc4PhfUwhUUN3ME2yNU4yKM7:TR?= M{LuZ|E6PTh7Nke4
Vero cells MXLDfZRwfG:6aXPpeJkh[XO|YYm= MkHGR5l1d3SxeHnjbZR6KGGpYXnud5QhXmW{bzDj[YxteyxiSVO1NF0zOi53IN88US=> NXrMUmdUOTZ5MkK2OlQ>
human A2780 cells MX7Qdo9tcW[ncnH0bY9vKGG|c3H5 MlT5RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDjbZNxdGG2aX6td4Vve2m2aY\lJIh2dWGwIFGyO|gxKGOnbHzzJIJ6KE2WVDDhd5NigSxiSVO1NF0{OC53IN88US=> MVuxPVU5QTZ5OB?=
human SPC-A1 cells NIL3bG5Rem:uaX\ldoF1cW:wIHHzd4F6 M1fXU2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iU2DDMWEyKGOnbHzzJIJ6KE2WVDDhd5NigSxiSVO1NF0{Pi5zIN88US=> NVHLUodzOTl3OEm2O|g>
HUVEC cells NVzFd2NLTnWwY4Tpc44h[XO|YYm= NWnVc5JnOjBizszN M3Hr[|I1KGh? M3WxPGFvfGmvaXfyZZRwenliYXP0bZZqfHliYXfhbY5{fCCqdX3hckBJXV[HQzDj[YxteyCjdDCyNEB2VSCjZoTldkAzPCCqcoOgZpkhf2:3bnStbIVidGmwZzDhd5NigQ>? MoHiNlE5PTN7OUG=
HEK293 cells MlyySpVv[3Srb36gZZN{[Xl? NVvmXmtUOjRvNEigbC=> M3f6OmFod26rc4SgZYN1cX[rdImgZZQhcHWvYX6gVnhTNWGucHjhJIV5eHKnc4Pl[EBqdiCKRVuyPVMh[2WubIOgZ49mgHC{ZYPzbY5oKHerdHigdGNOYC2kZYThMYdidCCjZoTldkAzPCC2bzC0PEBpenNiYomgcJVkcW[ncnHz[UBz\XCxcoTldkBo\W6nIHHzd4F6 NHHoPHkzPDl3OUm4Oy=>
human SH-SY5Y cells MkP3SpVv[3Srb36gZZN{[Xl? NUTRRWNIOTBizszN M3LlfVMxKG2rboO= NG\we2VP\XW{b4Dyc5Rm[3SrdnWgZYN1cX[rdImgbY4hcHWvYX6gV2guW1l3WTDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKEOKUDDhcoQhXEKKUD3pcoR2[2WmIHPlcIwh\GWjdHigZZQhOTBidV2gbY5kfWKjdHXkJIZweiB|MDDtbY5{KHC{aX;yJJRwKGOqYXzs[Y5o\SCvZXHzeZJm\CCjZoTldkA{KGi{czDifUBOXFRiYYPzZZk> M1\hSFIzOTR{NUO5

... Click to View More Cell Line Experimental Data

In vivo Honokiol is highly effective against SVR angiosarcoma in nude mice. [1] Honokiol inhibits the growth of RKO cells in murine xenografts. [4] Honokiol prevents the growth of MDA-MD-231 breast cancer cells in murine xenografts. [7]

Protocol

Solubility (25°C)

In vitro DMSO 53 mg/mL (198.99 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+40% PEG 300+2% Tween 80+ddH2O
For best results, use promptly after mixing.
2mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 266.334
Formula

C18H18O2

CAS No. 35354-74-6
Storage powder
in solvent
Synonyms N/A

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID