Research Area
Product Type
United States ( Change Country )
Honokiol Chemical Structure
Recommended Products
(-)-Epigallocatechin gallate
(-)-Epigallocatechin gallate is a potent anti-oxidant polyphenol flavonoid isolated from green tea.
(+)-Usniacin (D-Usnic acid)
(+)-Usniacin(D-Usnic acid) is a naturally occurring dibenzofuran derivative found in several lichen species.
3-Indolebutyric acid (IBA)
3-Indolebutyric acid(IBA) is a plant hormone in the auxin family and is an ingredient in many commercial plant rooting horticultural products.
4-Methylumbelliferone(4-MU)
4-Methylumbelliferone is a hyaluronic acid (HA) synthesis inhibitor with an IC50 of 0.4 mM.
Aesculin (Esculin)
Aesculin(Esculin) is a glucoside found in horse chestnuts.
Aloe-emodin
Aloe-emodin is an interferon-inducing agent with IC50 of about 1 μg/mL for JEV and of about 0.33 μg/mL for EV71.
Amygdalin
Amygdalin is a glycoside initially isolated from the seeds of the tree Prunus dulcis, also known as bitter almonds.
Andrographolide
Andrographolide is a labdane diterpenoid that is the main bioactive component of the medicinal plant Andrographis paniculata.
Arbutin (Uva, p-Arbutin)
Arbutin(Uvasol, p-Arbutin) is a tyrosinase inhibitor with an IC50 of 1.09 mM.
Artesunate
Artesunate is a part of the artemisinin group of agents with an IC50 of < 5 μM for small cell lung carcinoma cell line H69.
Biological Activity
Honokiol is a biphenolic compound present in the cones, bark, and leaves of Magnolia grandifloris. It inhibits phosphorylation of Akt, p44/42 mitogen-activated protein kinase (MAPK), and src. Additionally, honokiol modulates the nuclear factor kappa B (NF-κB) activation pathway, an upstream effector of vascular endothelial growth factor (VEGF), cyclooxygenase 2 (COX-2), and MCL1, all significant pro-angiogenic and survival factors. Honokiol induces caspase-dependent apoptosis in a TRAIL-mediated manner, and potentiates the pro-apoptotic effects of doxorubicin and other etoposides. Honokiol has been shown to promote neurite outgrowth and have neuroprotective effects in rat cortical neurons. [1]
Chemical Information
| Molecular Weight (WM): | 266.334 |
|---|---|
| Formula: | C18H18O2 |
| CAS No.: | 35354-74-6 |
| Synonyms: |
N/A
|
| Dissolve in (25°C): | DMSO ≥53mg/mL |
| Water ≥53mg/mL | |
| Ethanol <1mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
Quality Control & MSDS
Research Area
Others >> Others >> Other Inhibitors
MAPK >> MEK >> MEK Inhibitors
PI3K / mTOR / AKT >> AKT >> AKT Inhibitors
MAPK >> MEK >> MEK Inhibitors
PI3K / mTOR / AKT >> AKT >> AKT Inhibitors
Notes:
Related Inhibitors
Related Antibodies
Recommended Screening Libraries
Chemical Library
A collection of 864 bioactive compounds
Inhibitor Library
A collection of 481 inhibitors
Kinase Inhibitor Library
A collection of 194 kinase inhibitors
Tyrosine Kinase Inhibitor Library
A collection of 85 tyrosine kinase inhibitors.
FDA Approved Drug Library
A collection of 426 FDA approved drugs
Natural Product Library
A collection of 139 natural products
Chemotherapeutic Agent Library
A collection of 40 chemotherapeutic agents
Epigenetics Compound library
A unique collection of 17 small molecule modulators
Stem Cell Compound library
A unique collection of 47 small molecule inhibitors
GPCR Compound library
A unique collection of 63 GPCR small molecules
Recently Viewed Items
Keywords:buy Honokiol | Honokiol supplier | purchase Honokiol | Honokiol cost | Honokiol manufacturer | order Honokiol | Honokiol distributor