Honokiol

Catalog No.S2310

Honokiol Chemical Structure

Molecular Weight(MW): 266.334

Honokiol is the active principle of magnolia extract that inhibits Akt-phosphorylation and promotes ERK1/2 phosphorylation. Phase 3.

Size Price Stock Quantity  
In DMSO USD 110 In stock
USD 88 In stock
USD 148 In stock
USD 260 In stock
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  • (B) Cleaved PARP, Bax and Bcl2 protein expression was evaluated by immunoblotting of KRAS mutant cells lysates after 48 h of honokiol (10, 20, 40, and 60 μM) treatment. ∗∗P < 0.01 and ∗∗∗P < 0.001 for comparison between control group and honokiol-treated group.

    Front Pharmacol, 2017. Honokiol purchased from Selleck.

Purity & Quality Control

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Biological Activity

Description Honokiol is the active principle of magnolia extract that inhibits Akt-phosphorylation and promotes ERK1/2 phosphorylation. Phase 3.
Targets
Akt-phosphorylation [1] MEK [1]
In vitro

Honokiol shows pro-apoptotic effects in melanoma, sarcoma, myeloma, leukemia, bladder, lung, prostate, oral squamous cell carcinoma and colon cancer cell lines. Honokiol is effective on inducing apoptosis in SVR angiosarcoma cells. Treatment of SVR cells with honokiol causes decreased phosphorylation of MAP kinase, akt, and c-src. In addition, honokiol potentiates TRAIL-mediated apoptosis, and honokiol cytotoxicity is partially abrogated by neutralizing antibodies to TRAIL. Honokiol also has direct antiangiogenic activity, in that honokiol blocks the phosphorylation and rac activation due to VEGF-VEGFR2 interactions. [1] Honokiol causes apoptosis in CLL cells through activation of caspase 8, followed by caspase 9 and 3 activation. Honokiol prevents interleukin-4-mediated survival of CLL cells, and potentiats the cytotoxicity of chlorambucil, fludarabine, and cladribine. [3] Honokiol kills myeloma cells from relapsed patients at doses that does not kill PBMCs. Caspase 3, 7, 8, and 9 are induced by honokiol treatment, as well as PARP cleavage. [2] Honokiol is found to induce apoptosis in the colon cancer cell lines RKO. [4] Honokiol potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through modulation of nuclear factor-kappaB activation pathway. [5] Honokiol may act as a potent anti-inflammatory agent with multipotential activities due to an inhibitory effect on the PI3K/Akt pathway. [6]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human UACC-903 cells MYDDfZRwfG:6aXPpeJkh[XO|YYm= Moq4R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gWWFESy17MEOgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WUzDhd5NigSxiSVO1NF02NjFizszN NVXaNYF3OjJ3M{O5PFM>
Vero E6 cells NGjK[WpHfW6ldHnvckBie3OjeR?= NGe4VZpCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBUSVKVIHPvdo9v[X[rcoXzJIlvKF[ncn:gSVYh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJidCC{ZYDsbYNifGmxbjDifUBGVEmVQTygSWM2OD14LkWg{txO M1HyXlE4PjZ|NUO5
human UACC-903 cells M4jRfWN6fG:2b4jpZ4l1gSCjc4PhfS=> MVvDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDVRWNENTlyMzDj[YxteyCjZoTldkAzPCCqcoOgZpkhVVSVIHHzd4F6NCCLQ{WwQVcvPDVizszN MWKyNlU{Ozl6Mx?=
human A549 cells NVPjcIJzS3m2b4TvfIlkcXS7IHHzd4F6 MnnpR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVU1QSClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRUKGG|c3H5MEBKSzVyPUeuO|Uh|ryP NHnmcGMzOjV|M{m4Ny=>
human CEM cells NEjGZpNEgXSxdH;4bYNqfHliYYPzZZk> MmDQR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gR2VOKGOnbHzzMEBKSzVyPUGwMlkh|ryP NHuwdIkyPzV6N{W3Ni=>
HEK293 cells NF\yfZdHfW6ldHnvckBie3OjeR?= MXnB[49vcXO2IHHjeIl3cXS7IHH0JHJZWmGucHjhJIlvKEiHS{K5N{Bk\WyuczDhd5Nme3OnZDDhd{B1emGwc3PybZB1cW:wYXygZYN1cX[jdHnvckBi\nSncjC0PEBpenNiYomgcJVkcW[ncnHz[UBz\XCxcoTldkBo\W6nIHHzd4F6NCCHQ{WwQVEyNjhizszN NVi3dXM6OjB4OUW0O|I>
human A549 cell MkHDR5l1d3SxeHnjbZR6KGG|c3H5 NXn4Rol2OjRiaB?= MUTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIFnfGW{IEK0JIhzeyCkeTDNWHMh[XO|YYmsJGlEPTB;MUKuOVEh|ryP MnviNlI2OzN7OEO=
human HT-29 cells MUfDfZRwfG:6aXPpeJkh[XO|YYm= NUPNXoVOPzJiaB?= MmPoR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTHQuOjliY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VWyCjc4PhfUwhUUN3ME2xN{4zPCEQvF2= NFztUFMzOjV|M{m4Ny=>
human PBM cells MkDGR5l1d3SxeHnjbZR6KGG|c3H5 NWnTXoI4S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hWEKPIHPlcIx{NCCLQ{WwQVE3NjFizszN M1nyd|E4PTh5NUey
Hep-G2 cells NYHlNZk5S3m2b4TvfIlkcXS7IHHzd4F6 NYDXOm0yS3m2b4TvfIlkcXS7IH;mJINwdXCxdX7kJIFo[Wmwc4SgbJVu[W5ibHn2[ZIhfHWvb4KgZ4VtdCCuaX7lJEhJ\XBvR{KpJJdieyCmZYTldo1qdmWmLDDJR|UxRTF4LkWg{txO M{\tW|E2PTh{NEOy
human HepG2 cells MV;Qdo9tcW[ncnH0bY9vKGG|c3H5 MofUNlQhcA>? MoH3RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKZYDHNkBk\WyuczDh[pRmeiB{NDDodpMh[nliTWTUJIF{e2G7LDDJR|UxRTF4LkWg{txO NHrTbHMzOTh3M{m5NS=>
human K562 cells M4\OS3Bzd2yrZnXyZZRqd25iYYPzZZk> M1;LemFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iS{W2NkBk\WyuczDifUBOXFRiYYPzZZktKEmFNUC9NlEvOSEQvF2= M3rIRVE6PTh7Nke4
Vero cells MXfDfZRwfG:6aXPpeJkh[XO|YYm= NUTLZWh3S3m2b4TvfIlkcXS7IHHnZYlve3RiVnXyc{Bk\WyuczygTWM2OD1{Mj61JO69VQ>? NETOdGYyPjd{Mk[2OC=>
human A2780 cells NXToZmlvWHKxbHnm[ZJifGmxbjDhd5NigQ>? M4fjT2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgZ4l{eGyjdHnuMZNmdnOrdHn2[UBpfW2jbjDBNlc5OCClZXzsd{BjgSCPVGSgZZN{[XluIFnDOVA:OzBwNTFOwG0> MXKxPVU5QTZ5OB?=
human SPC-A1 cells NH;1bI1Rem:uaX\ldoF1cW:wIHHzd4F6 NUOzRphPSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDTVGMuSTFiY3XscJMh[nliTWTUJIF{e2G7LDDJR|UxRTN4LkGg{txO MX[xPVU5QTZ5OB?=
HUVEC cells M{jwbmZ2dmO2aX;uJIF{e2G7 MV[yNEDPxE1? NF70[oIzPCCq M1q3eGFvfGmvaXfyZZRwenliYXP0bZZqfHliYXfhbY5{fCCqdX3hckBJXV[HQzDj[YxteyCjdDCyNEB2VSCjZoTldkAzPCCqcoOgZpkhf2:3bnStbIVidGmwZzDhd5NigQ>? M3PwT|IyQDV|OUmx
HEK293 cells MlfuSpVv[3Srb36gZZN{[Xl? NFfONFAzPC12ODDo MojlRYdwdmm|dDDhZ5Rqfmm2eTDheEBpfW2jbjDSXHIu[WyyaHGg[ZhxemW|c3XkJIlvKEiHS{K5N{Bk\WyuczDjc4V5eHKnc4Ppcochf2m2aDDwR21ZNWKndHGt[4FtKGGodHXyJFI1KHSxIES4JIhzeyCkeTDseYNq\mW{YYPlJJJmeG:{dHXyJIdmdmViYYPzZZk> MkC2NlQ6PTl7OEe=
human SH-SY5Y cells MU\GeY5kfGmxbjDhd5NigQ>? MWixNEDPxE1? NIf6WGY{OCCvaX7z MonwUoV2em:ycn;0[YN1cX[nIHHjeIl3cXS7IHnuJIh2dWGwIGPIMXN[PVliY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBEUFBiYX7kJHRDUFBvaX7keYNm\CClZXzsJIRm[XSqIHH0JFExKHWPIHnuZ5Vj[XSnZDDmc5IhOzBibXnud{BxemmxcjD0c{BkcGGubHXu[4UhdWWjc4Xy[YQh[W[2ZYKgN{BpenNiYomgUXRVKGG|c3H5 NV;LWGN[OjJzNEK1N|k>

... Click to View More Cell Line Experimental Data

In vivo Honokiol is highly effective against SVR angiosarcoma in nude mice. [1] Honokiol inhibits the growth of RKO cells in murine xenografts. [4] Honokiol prevents the growth of MDA-MD-231 breast cancer cells in murine xenografts. [7]

Protocol

Solubility (25°C)

In vitro DMSO 53 mg/mL (198.99 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 266.334
Formula

C18H18O2

CAS No. 35354-74-6
Storage powder
Synonyms N/A

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID