Honokiol

Catalog No.S2310

Honokiol Chemical Structure

Molecular Weight(MW): 266.334

Honokiol is the active principle of magnolia extract that inhibits Akt-phosphorylation and promotes ERK1/2 phosphorylation. Phase 3.

Size Price Stock Quantity  
In DMSO USD 110 In stock
USD 88 In stock
USD 148 In stock
USD 260 In stock
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1 Customer Review

  • (B) Cleaved PARP, Bax and Bcl2 protein expression was evaluated by immunoblotting of KRAS mutant cells lysates after 48 h of honokiol (10, 20, 40, and 60 μM) treatment. ∗∗P < 0.01 and ∗∗∗P < 0.001 for comparison between control group and honokiol-treated group.

    Front Pharmacol, 2017. Honokiol purchased from Selleck.

Purity & Quality Control

Choose Selective Akt Inhibitors

Biological Activity

Description Honokiol is the active principle of magnolia extract that inhibits Akt-phosphorylation and promotes ERK1/2 phosphorylation. Phase 3.
Targets
Akt-phosphorylation [1] MEK [1]
In vitro

Honokiol shows pro-apoptotic effects in melanoma, sarcoma, myeloma, leukemia, bladder, lung, prostate, oral squamous cell carcinoma and colon cancer cell lines. Honokiol is effective on inducing apoptosis in SVR angiosarcoma cells. Treatment of SVR cells with honokiol causes decreased phosphorylation of MAP kinase, akt, and c-src. In addition, honokiol potentiates TRAIL-mediated apoptosis, and honokiol cytotoxicity is partially abrogated by neutralizing antibodies to TRAIL. Honokiol also has direct antiangiogenic activity, in that honokiol blocks the phosphorylation and rac activation due to VEGF-VEGFR2 interactions. [1] Honokiol causes apoptosis in CLL cells through activation of caspase 8, followed by caspase 9 and 3 activation. Honokiol prevents interleukin-4-mediated survival of CLL cells, and potentiats the cytotoxicity of chlorambucil, fludarabine, and cladribine. [3] Honokiol kills myeloma cells from relapsed patients at doses that does not kill PBMCs. Caspase 3, 7, 8, and 9 are induced by honokiol treatment, as well as PARP cleavage. [2] Honokiol is found to induce apoptosis in the colon cancer cell lines RKO. [4] Honokiol potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through modulation of nuclear factor-kappaB activation pathway. [5] Honokiol may act as a potent anti-inflammatory agent with multipotential activities due to an inhibitory effect on the PI3K/Akt pathway. [6]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human UACC-903 cells M1ntUGN6fG:2b4jpZ4l1gSCjc4PhfS=> NXzTeJVIS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hXUGFQz25NFMh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UV{Bie3OjeTygTWM2OD13LkGg{txO NFXYWm4zOjV|M{m4Ny=>
Vero E6 cells MkfUSpVv[3Srb36gZZN{[Xl? NH\WWlRCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBUSVKVIHPvdo9v[X[rcoXzJIlvKF[ncn:gSVYh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJidCC{ZYDsbYNifGmxbjDifUBGVEmVQTygSWM2OD14LkWg{txO NGG5eXgyPzZ4M{WzPS=>
human UACC-903 cells MWDDfZRwfG:6aXPpeJkh[XO|YYm= NXHSOG12S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hXUGFQz25NFMh[2WubIOgZYZ1\XJiMkSgbJJ{KGK7IF3UV{Bie3OjeTygTWM2OD15LkS1JO69VQ>? M{G2UFIzPTN|OUiz
human A549 cells NG\ze41EgXSxdH;4bYNqfHliYYPzZZk> MWPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHMh[XO|YYmsJGlEPTB;Nz63OUDPxE1? NWWyblBnOjJ3M{O5PFM>
human CEM cells M3HuPWN6fG:2b4jpZ4l1gSCjc4PhfS=> NHi2d2ZEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBETU1iY3XscJMtKEmFNUC9NVAvQSEQvF2= MlTRNVc2QDd3N{K=
HEK293 cells MWjGeY5kfGmxbjDhd5NigQ>? MYrB[49vcXO2IHHjeIl3cXS7IHH0JHJZWmGucHjhJIlvKEiHS{K5N{Bk\WyuczDhd5Nme3OnZDDhd{B1emGwc3PybZB1cW:wYXygZYN1cX[jdHnvckBi\nSncjC0PEBpenNiYomgcJVkcW[ncnHz[UBz\XCxcoTldkBo\W6nIHHzd4F6NCCHQ{WwQVEyNjhizszN MojkNlA3QTV2N{K=
human A549 cell NHXhU4tEgXSxdH;4bYNqfHliYYPzZZk> NGnOWmgzPCCq NHLy[HREgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPTR7IHPlcIx{KGGodHXyJFI1KGi{czDifUBOXFNiYYPzZZktKEmFNUC9NVIvPTFizszN MX[yNlU{Ozl6Mx?=
human HT-29 cells MULDfZRwfG:6aXPpeJkh[XO|YYm= MU[3NkBp Ml;KR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTHQuOjliY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VWyCjc4PhfUwhUUN3ME2xN{4zPCEQvF2= NYS4cWdYOjJ3M{O5PFM>
human PBM cells NWnnPXhyS3m2b4TvfIlkcXS7IHHzd4F6 M4TTWGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHBDVSClZXzsd{whUUN3ME2xOk4yKM7:TR?= MorCNVc2QDd3N{K=
Hep-G2 cells MXjDfZRwfG:6aXPpeJkh[XO|YYm= NIPNO2VEgXSxdH;4bYNqfHlib3[gZ49ueG:3bnSgZYdicW6|dDDoeY1idiCuaY\ldkB1fW2xcjDj[YxtKGyrbnWgLGhmeC2JMjmge4F{KGSndHXycYlv\WRuIFnDOVA:OTZwNTFOwG0> Mkf3NVU2QDJ2M{K=
human HepG2 cells MnrSVJJwdGmoZYLheIlwdiCjc4PhfS=> NFPFUm8zPCCq NVKyfJozSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bi\nSncjCyOEBpenNiYomgUXRVKGG|c3H5MEBKSzVyPUG2MlUh|ryP M2rtOFIyQDV|OUmx
human K562 cells Mm\BVJJwdGmoZYLheIlwdiCjc4PhfS=> NFuwTZNCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFu1OlIh[2WubIOgZpkhVVSWIHHzd4F6NCCLQ{WwQVIyNjFizszN MWGxPVU5QTZ5OB?=
Vero cells NVv5OGxYS3m2b4TvfIlkcXS7IHHzd4F6 M2TufWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KF[ncn:gZ4VtdHNuIFnDOVA:OjJwNTFOwG0> NEP3XVYyPjd{Mk[2OC=>
human A2780 cells MnPmVJJwdGmoZYLheIlwdiCjc4PhfS=> NHzROpNCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JINqe3CuYYTpck1{\W6|aYTpeoUhcHWvYX6gRVI4QDBiY3XscJMh[nliTWTUJIF{e2G7LDDJR|UxRTNyLkWg{txO NY\BWHFLOTl3OEm2O|g>
human SPC-A1 cells M1rFfXBzd2yrZnXyZZRqd25iYYPzZZk> M1LQbmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iU2DDMWEyKGOnbHzzJIJ6KE2WVDDhd5NigSxiSVO1NF0{Pi5zIN88US=> NH7YW2gyQTV6OU[3PC=>
HUVEC cells MYXGeY5kfGmxbjDhd5NigQ>? MonsNlAh|ryP MYqyOEBp M3vOXGFvfGmvaXfyZZRwenliYXP0bZZqfHliYXfhbY5{fCCqdX3hckBJXV[HQzDj[YxteyCjdDCyNEB2VSCjZoTldkAzPCCqcoOgZpkhf2:3bnStbIVidGmwZzDhd5NigQ>? Ml[3NlE5PTN7OUG=
HEK293 cells MmHUSpVv[3Srb36gZZN{[Xl? NVfD[3RmOjRvNEigbC=> MlvpRYdwdmm|dDDhZ5Rqfmm2eTDheEBpfW2jbjDSXHIu[WyyaHGg[ZhxemW|c3XkJIlvKEiHS{K5N{Bk\WyuczDjc4V5eHKnc4Ppcochf2m2aDDwR21ZNWKndHGt[4FtKGGodHXyJFI1KHSxIES4JIhzeyCkeTDseYNq\mW{YYPlJJJmeG:{dHXyJIdmdmViYYPzZZk> MlX1NlQ6PTl7OEe=
human SH-SY5Y cells NWTqUpBHTnWwY4Tpc44h[XO|YYm= NXr4SmVROTBizszN MmrhN|AhdWmwcx?= NV\sflNtVmW3cn;wdo91\WO2aY\lJIFkfGm4aYT5JIlvKGi3bXHuJHNJNVO\NWmgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCFSGCgZY5lKFSESGCtbY5lfWOnZDDj[YxtKGSnYYToJIF1KDFyIIXNJIlv[3WkYYTl[EBnd3JiM{CgcYlveyCycnnvdkB1dyClaHHscIVv\2VibXXhd5Vz\WRiYX\0[ZIhOyCqcoOgZpkhVVSWIHHzd4F6 MWeyNlE1OjV|OR?=

... Click to View More Cell Line Experimental Data

In vivo Honokiol is highly effective against SVR angiosarcoma in nude mice. [1] Honokiol inhibits the growth of RKO cells in murine xenografts. [4] Honokiol prevents the growth of MDA-MD-231 breast cancer cells in murine xenografts. [7]

Protocol

Solubility (25°C)

In vitro DMSO 53 mg/mL (198.99 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 266.334
Formula

C18H18O2

CAS No. 35354-74-6
Storage powder
Synonyms N/A

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID