Honokiol

Catalog No.S2310

Honokiol Chemical Structure

Molecular Weight(MW): 266.334

Honokiol is the active principle of magnolia extract that inhibits Akt-phosphorylation and promotes ERK1/2 phosphorylation. Phase 3.

Size Price Stock Quantity  
In DMSO USD 110 In stock
USD 88 In stock
USD 148 In stock
USD 260 In stock
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1 Customer Review

  • (B) Cleaved PARP, Bax and Bcl2 protein expression was evaluated by immunoblotting of KRAS mutant cells lysates after 48 h of honokiol (10, 20, 40, and 60 μM) treatment. ∗∗P < 0.01 and ∗∗∗P < 0.001 for comparison between control group and honokiol-treated group.

    Front Pharmacol, 2017. Honokiol purchased from Selleck.

Purity & Quality Control

Choose Selective Akt Inhibitors

Biological Activity

Description Honokiol is the active principle of magnolia extract that inhibits Akt-phosphorylation and promotes ERK1/2 phosphorylation. Phase 3.
Targets
Akt-phosphorylation [1] MEK [1]
In vitro

Honokiol shows pro-apoptotic effects in melanoma, sarcoma, myeloma, leukemia, bladder, lung, prostate, oral squamous cell carcinoma and colon cancer cell lines. Honokiol is effective on inducing apoptosis in SVR angiosarcoma cells. Treatment of SVR cells with honokiol causes decreased phosphorylation of MAP kinase, akt, and c-src. In addition, honokiol potentiates TRAIL-mediated apoptosis, and honokiol cytotoxicity is partially abrogated by neutralizing antibodies to TRAIL. Honokiol also has direct antiangiogenic activity, in that honokiol blocks the phosphorylation and rac activation due to VEGF-VEGFR2 interactions. [1] Honokiol causes apoptosis in CLL cells through activation of caspase 8, followed by caspase 9 and 3 activation. Honokiol prevents interleukin-4-mediated survival of CLL cells, and potentiats the cytotoxicity of chlorambucil, fludarabine, and cladribine. [3] Honokiol kills myeloma cells from relapsed patients at doses that does not kill PBMCs. Caspase 3, 7, 8, and 9 are induced by honokiol treatment, as well as PARP cleavage. [2] Honokiol is found to induce apoptosis in the colon cancer cell lines RKO. [4] Honokiol potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through modulation of nuclear factor-kappaB activation pathway. [5] Honokiol may act as a potent anti-inflammatory agent with multipotential activities due to an inhibitory effect on the PI3K/Akt pathway. [6]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human UACC-903 cells M16zXWN6fG:2b4jpZ4l1gSCjc4PhfS=> MkTXR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gWWFESy17MEOgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WUzDhd5NigSxiSVO1NF02NjFizszN NEnk[GkzOjV|M{m4Ny=>
Vero E6 cells MWPGeY5kfGmxbjDhd5NigQ>? MVrBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDTRXJUKGOxcn;uZZZqenW|IHnuJHZmem9iRU[gZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYLhcEBz\XCuaXPheIlwdiCkeTDFUGlUSSxiRVO1NF03NjVizszN M2S1RVE4PjZ|NUO5
human UACC-903 cells MnG1R5l1d3SxeHnjbZR6KGG|c3H5 MXzDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDVRWNENTlyMzDj[YxteyCjZoTldkAzPCCqcoOgZpkhVVSVIHHzd4F6NCCLQ{WwQVcvPDVizszN MmK1NlI2OzN7OEO=
human A549 cells MnvmR5l1d3SxeHnjbZR6KGG|c3H5 NGr4Z4dEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPTR7IHPlcIx{KGGodHXyJFczKGi{czDifUBOXFNiYYPzZZktKEmFNUC9O{44PSEQvF2= MV2yNlU{Ozl6Mx?=
human CEM cells MmXqR5l1d3SxeHnjbZR6KGG|c3H5 MXvDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDDSW0h[2WubIOsJGlEPTB;MUCuPUDPxE1? MVKxO|U5PzV5Mh?=
HEK293 cells MWjGeY5kfGmxbjDhd5NigQ>? MmriRYdwdmm|dDDhZ5Rqfmm2eTDheEBTYFKjbIDoZUBqdiCKRVuyPVMh[2WubIOgZZN{\XO|ZXSgZZMhfHKjboPjdolxfGmxbnHsJIFkfGm4YYTpc44h[W[2ZYKgOFghcHK|IHL5JIx2[2moZYLhd4UhemWyb4L0[ZIh\2WwZTDhd5NigSxiRVO1NF0yOS56IN88US=> NHP3XVMzODZ7NUS3Ni=>
human A549 cell Mln4R5l1d3SxeHnjbZR6KGG|c3H5 NH\TV|YzPCCq NHvIN2xEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPTR7IHPlcIx{KGGodHXyJFI1KGi{czDifUBOXFNiYYPzZZktKEmFNUC9NVIvPTFizszN NUPJfYdROjJ3M{O5PFM>
human HT-29 cells M37ub2N6fG:2b4jpZ4l1gSCjc4PhfS=> NUjFbFNrPzJiaB?= MVvDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIWE0zQSClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRUKGG|c3H5MEBKSzVyPUGzMlI1KM7:TR?= NXTRcmpNOjJ3M{O5PFM>
human PBM cells MmeyR5l1d3SxeHnjbZR6KGG|c3H5 MofpR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gVGJOKGOnbHzzMEBKSzVyPUG2MlEh|ryP MmCwNVc2QDd3N{K=
Hep-G2 cells Mn\BR5l1d3SxeHnjbZR6KGG|c3H5 NHLOPFREgXSxdH;4bYNqfHlib3[gZ49ueG:3bnSgZYdicW6|dDDoeY1idiCuaY\ldkB1fW2xcjDj[YxtKGyrbnWgLGhmeC2JMjmge4F{KGSndHXycYlv\WRuIFnDOVA:OTZwNTFOwG0> M4m4ZVE2PTh{NEOy
human HepG2 cells M1SzeXBzd2yrZnXyZZRqd25iYYPzZZk> MX2yOEBp Ml;4RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKZYDHNkBk\WyuczDh[pRmeiB{NDDodpMh[nliTWTUJIF{e2G7LDDJR|UxRTF4LkWg{txO NILPVYwzOTh3M{m5NS=>
human K562 cells NX\nPZNlWHKxbHnm[ZJifGmxbjDhd5NigQ>? NIHMN3NCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFu1OlIh[2WubIOgZpkhVVSWIHHzd4F6NCCLQ{WwQVIyNjFizszN M4fKZVE6PTh7Nke4
Vero cells MYTDfZRwfG:6aXPpeJkh[XO|YYm= MVPDfZRwfG:6aXPpeJkh[WejaX7zeEBX\XKxIHPlcIx{NCCLQ{WwQVIzNjVizszN M2fTSVE3PzJ{Nk[0
human A2780 cells MlPRVJJwdGmoZYLheIlwdiCjc4PhfS=> M4DlVWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgZ4l{eGyjdHnuMZNmdnOrdHn2[UBpfW2jbjDBNlc5OCClZXzsd{BjgSCPVGSgZZN{[XluIFnDOVA:OzBwNTFOwG0> NIS0c2oyQTV6OU[3PC=>
human SPC-A1 cells NGfaUpBRem:uaX\ldoF1cW:wIHHzd4F6 NVTXW4x7SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDTVGMuSTFiY3XscJMh[nliTWTUJIF{e2G7LDDJR|UxRTN4LkGg{txO MVKxPVU5QTZ5OB?=
HUVEC cells MoXsSpVv[3Srb36gZZN{[Xl? NITPbJAzOCEQvF2= NHLUPYszPCCq NVXUdZlUSW62aX3p[5JifG:{eTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiXVlXDJINmdGy|IHH0JFIxKHWPIHHmeIVzKDJ2IHjyd{BjgSC5b4Xu[E1p\WGuaX7nJIF{e2G7 MXqyNVg2Ozl7MR?=
HEK293 cells NIH4ZoNHfW6ldHnvckBie3OjeR?= MUeyOE01QCCq NUHQZ3dESWexbnnzeEBi[3Srdnn0fUBifCCqdX3hckBTYFJvYXzwbIEh\XiycnXzd4VlKGmwIFjFT|I6OyClZXzsd{Bkd2W6cILld5Nqdmdid3n0bEBxS02[LXLleIEu\2GuIHHmeIVzKDJ2IITvJFQ5KGi{czDifUBtfWOrZnXyZZNmKHKncH;yeIVzKGenbnWgZZN{[Xl? M1jHdlI1QTV7OUi3
human SH-SY5Y cells MkexSpVv[3Srb36gZZN{[Xl? M{OwbVExKM7:TR?= M1XmNVMxKG2rboO= NHXMOmtP\XW{b4Dyc5Rm[3SrdnWgZYN1cX[rdImgbY4hcHWvYX6gV2guW1l3WTDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKEOKUDDhcoQhXEKKUD3pcoR2[2WmIHPlcIwh\GWjdHigZZQhOTBidV2gbY5kfWKjdHXkJIZweiB|MDDtbY5{KHC{aX;yJJRwKGOqYXzs[Y5o\SCvZXHzeZJm\CCjZoTldkA{KGi{czDifUBOXFRiYYPzZZk> NX3OdnN7OjJzNEK1N|k>

... Click to View More Cell Line Experimental Data

In vivo Honokiol is highly effective against SVR angiosarcoma in nude mice. [1] Honokiol inhibits the growth of RKO cells in murine xenografts. [4] Honokiol prevents the growth of MDA-MD-231 breast cancer cells in murine xenografts. [7]

Protocol

Solubility (25°C)

In vitro DMSO 53 mg/mL (198.99 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 266.334
Formula

C18H18O2

CAS No. 35354-74-6
Storage powder
Synonyms N/A

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID