Idelalisib (CAL-101, GS-1101)

Catalog No.S2226

Idelalisib (CAL-101, GS-1101) Chemical Structure

Molecular Weight(MW): 415.42

Idelalisib (CAL-101, GS-1101) is a selective p110δ inhibitor with IC50 of 2.5 nM in cell-free assays; shown to have 40- to 300-fold greater selectivity for p110δ than p110α/β/γ, and 400- to 4000-fold more selectivity to p110δ than C2β, hVPS34, DNA-PK and mTOR.

Size Price Stock Quantity  
In DMSO USD 156 In stock
USD 120 In stock
USD 470 In stock
Bulk Discount

Free Overnight Delivery on orders over $ 500
Next day delivery by 10:00 a.m. Order now.

Cited by 29 Publications

4 Customer Reviews

  • Invasive migration of RA FLS was analyzed through growth factor–reduced Matrigel-coated transwell inserts in the presence or absence of 1 µM INK007, 5 µM CAL-101, or 0.3 µM IPI-145, or 0.3 µM GDC-0941 inhibitors or DMSO. Cells were allowed to invade through Matrigel toward PDGF-BB (25 ng/ml) containing media for 24 h and were fixed and stained with Hemacolor staining kit.

    J Immunol, 2014, 192(5): 2063-70 . Idelalisib (CAL-101, GS-1101) purchased from Selleck.

    293T cells were transfected with HA-tagged Fbxo45. At 48 h after transfection, cells were treated with AKT inhibitor (CAL-101; 10 uM, 4 h), cell extracts from the cytoplasm or nuclei were subjected to IP with anti-HA resin followed by western blot analysis with indicated antibodies.

    Cell Death Differ 2014 21(10), 1535-45. Idelalisib (CAL-101, GS-1101) purchased from Selleck.

  • Isoform-selective PI3K inhibitors blocked PI3K signaling in corresponding Rh30-Myr-p110 cells. Rh30-Myr-p110s cells were cultured in serum-free medium for 12 h, and then exposed to CAL-101 at indicated concentrations for additional 1 h. The cells were collected to detect the level of phosphorylated and total Akt. β-Actin was served as loading control.

    Acta Pharmacol Sin 2013 34(9),1201-7. Idelalisib (CAL-101, GS-1101) purchased from Selleck.

    After starved in serum-free medium for 24 h,A549 cells incubated with the indicated concentrations of CAL-101 for 3 h,followed by 20-minute stimolation of 100ng/ml EGF.

    Dr. Zhang of Tianjin Medical University. Idelalisib (CAL-101, GS-1101) purchased from Selleck.

Purity & Quality Control

Choose Selective PI3K Inhibitors

Biological Activity

Description Idelalisib (CAL-101, GS-1101) is a selective p110δ inhibitor with IC50 of 2.5 nM in cell-free assays; shown to have 40- to 300-fold greater selectivity for p110δ than p110α/β/γ, and 400- to 4000-fold more selectivity to p110δ than C2β, hVPS34, DNA-PK and mTOR.
Targets
p110δ [1]
(Cell-free assay)
p110γ [1]
(Cell-free assay)
2.5 nM 89 nM
In vitro

CAL-101 is not sensitive to other PI3K class I subunits including p110α, p110β, and p110γ. CAL-101 specifically blocks FcϵR1 p110δ-mediated CD63 expression with an EC50 of 8 nM in primary basophil. CAL-101 exhibits greater activity in B-cell acute lymphoblastic leukemia (B-ALL) and chronic lymphocytic leukemia (CLL) cells compared with acute myeloid leukemia (AML) and myeloproliferative neoplasm (MPN) cells. CAL-101 produces the reduction in pAktS473, pAktT308, and the downstream target S6 in SU-DHL-5, KARPAS-422 and CCRF-SB cells with EC50 of 0.1 to 1.0 μM. [1] CAL-101 induces selective cytotoxicity in CLL cells independent of IgVH mutational status or interphase cytogenetics, primarily through a caspase-dependent mechanism. CAL-101 induces cytotoxicity preferentially to CLL cells compared with normal B cells, without producing cytotoxicity in other hematopoietic cells, compared to LY294002. CAL-101 lacks direct cytotoxic potential to T cells and nature killer (NK) cells. CAL-101 can inhibit production of inflammatory cytokines, such as IL-6, IL-10, TNF-α, and IFN-γ, and activation-induced cytokines, such as CD40L. CAL-101 also antagonizes CD40L-mediated CLL cell survival. [2] CAL-101 induces an accumulation of cells in G1 and a decrease in the S-phase population in L1236 and L591 cells, which indicates CAL-101 as a novel strategy for the treatment of hodgkin lymphoma (HL). [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MEC1 NVjmSIFmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGKwVGtFVVOR NVLNTGJpUUN3ME2yNE41KM7:TR?= M1zme|I2QTl7M{Wy
CLL PBMCs MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnEUXNQ NYrTN4VHUUN3ME2yMlkhdk1? MUiyOVkyPzJ4Nx?=
U266 M2jveGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEDZVmo1OCEQvF2= MmrWOFghcA>? MnfwO|kvPSViaX7obYJqfGmxbjDyZZRm M1vn[lI2OzN7M{Oy
K562 MV\GeY5kfGmxbjDBd5NigQ>? NWmyXIloOSEQvF2= NF;VUmg{KGh? MlnvTY5pcWKrdHnvckBw\iCDa4SgdIhwe3Cqb4L5cIF1cW:w MYqyOVAyPDd5NR?=
K562 MVXGeY5kfGmxbjDBd5NigQ>? MUWxJO69VQ>? M376fVMhcA>? Mn\lTY5pcWKrdHnvckBw\iCSN{DTOmsheGixc4Doc5J6dGG2aX;u NYiw[nVmOjVyMUS3O|U>
K562 M3PF[WZ2dmO2aX;uJGF{e2G7 MmXKNUDPxE1? MorBN{Bp Mk[2TY5pcWKrdHnvckBw\iCJU1uzJJBpd3OyaH;yfYxifGmxbh?= MoTrNlUxOTR5N{W=
K562 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{Lvd|Eh|ryP NXvxe3VEPzJiaB?= NUjZVmxmUW6qaXLpeIlwdiCxZjDwdo9tcW[ncnH0bY9v M2rZVVI2ODF2N{e1
Primary AML cell M2\OXGZ2dmO2aX;uJGF{e2G7 MmLWNUDPxE1? NIjHV|Q{KGh? M{[y[2lvcGmkaYTpc44hd2ZiQXv0JJBpd3OyaH;yfYxifGmxbh?= M4TsVlI2ODF2N{e1
Primary AML cell MkS1SpVv[3Srb36gRZN{[Xl? MnX6NUDPxE1? NUK0eIxlOyCq NWXlXW1KUW6qaXLpeIlwdiCxZjDQO|BUPkticHjvd5Bpd3K7bHH0bY9v M2fKUVI2ODF2N{e1
Primary AML cell M{XzO2Z2dmO2aX;uJGF{e2G7 MlPnNUDPxE1? MV6zJIg> M3m5ZmlvcGmkaYTpc44hd2ZiR2PLN{BxcG:|cHjvdplt[XSrb36= NVWzPG1KOjVyMUS3O|U>
Primary AML cell NG\uW|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX[xJO69VQ>? MWSzJIg> MULTeZBxemW|c3nvckBw\iC{Ul7BJJN6dnSqZYPpdy=> MYGyOVAyPDd5NR?=
Microglia Mn\tSpVv[3Srb36gRZN{[Xl? MlT2OUDPxE1? MWqxNEBp MXjEUXNQ NHP4OWFF\WO{ZXHz[UBw\iCWTl\hJJNm[3KndHnvckBnem:vIFzQV{1{fGmvdXzheIVlKCCyMUGw{tRFQTFyQT;EPVExSSCvaXPyc4dtcWF? M3G0cVI1PjJ3Nki0
Primary CLL cell MUjGeY5kfGmxbjDBd5NigQ>? MkTXNUDPxE1? MXmxOUBucW5? NHXjSGZFVVOR M1XxZmJtd2OtczDCR3IucW6mdXPl[EBNS1BzIIPldolv\S13IHHjeIl3[XSrb36= M2LmbVI1ODB7MkOz
JEKO-1 NWHPU2hnTnWwY4Tpc44hSXO|YYm= MUKxJO69VQ>? MmOzO|IhcA>? NGm5NmZKdmirYnn0bY9vKG:oIFHreEBxcG:|cHjvdplt[XSrb36gbY4hUWePLYP0bY12dGG2ZXSgTmVMVy1z NHO1RVAzOzN2MUW0NS=>
Granta-519 MonESpVv[3Srb36gRZN{[Xl? MV:xJO69VQ>? MUWyJIg> M{fFc2lvcGmkaYTpc44hd2ZiQXv0LJQ{ODhrIIDoc5NxcG:{eXzheIlwdg>? M2ezdVI{OzRzNUSx
Granta-519 NEfVW|lHfW6ldHnvckBCe3OjeR?= M{TzNlEh|ryP NFPuNHYzKGh? Moq0TY5pcWKrdHnvckBw\iCDa4Sod|Q4OylicHjvd5Bpd3K7bHH0bY9v NIKwNmQzOzN2MUW0NS=>
JEKO-1 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUCxNEDPxE1? M3LnS|czKGh? NYTBXGlHUW6qaXLpeIlwdiCxZjDwdo9tcW[ncnH0bY9vKHOuaXfoeIx6 NXTvfZB1OjN|NEG1OFE>
JEKO-1 Mn\nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXG1JO69VQ>? NYPC[VJPPzJiaB?= MlG0[I9meyCwb4SgbY5lfWOnIHPlcIwh[3mlbHWgZZJz\XO2IH;yJIFxd3C2b4Ppdy=> NHzteWszOzZ5NkKyNC=>
MAVER-1 NGHrTllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXQOUDPxE1? NFj3N3Q4OiCq NFrmXmlld2W|IH7veEBqdmS3Y3WgZ4VtdCCleXPs[UBienKnc4Sgc5Ih[XCxcITvd4l{ M1rjb|I{Pjd4MkKw
MINO MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmXSOUDPxE1? MXW3NkBp M1PxOIRw\XNibn;0JIlv\HWlZTDj[YxtKGO7Y3zlJIFzemW|dDDvdkBieG:ydH;zbZM> MY[yN|Y4PjJ{MB?=
SP53 M2HLNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWnHPJd{OC5zIN88US=> NFLrRo44OiCq M3HWbIRw\XNibn;0JIlv\HWlZTDj[YxtKGO7Y3zlJIFzemW|dDDvdkBieG:ydH;zbZM> MkjtNlM3PzZ{MkC=
HH NGT4SJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3PNNlExKM7:TR?= NX7lfW94PzJiaB?= NYnQU5JJTE2VTx?= NFzKRndKdmS3Y4Tpc44hd2ZiYYDvdJRwe2m|IIPsbYdpfGy7 M1fXW|IzQDBzOUW5
Myla NV;KOYFpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX\a[VljOTBizszN NFfs[4o4OiCq NEW0WGRFVVOR NUfFUnd5\G:nczDuc5QhcW6mdXPlJIFxd3C2b4Ppdy=> NY\rOVBYOjJ6MEG5OVk>
SR786 MnTLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml7YNVAh|ryP MXm3NkBp Mo\jSG1UVw>? NIPlWJJld2W|IH7veEBqdmS3Y3WgZZBweHSxc3nz M1L5T|IzQDBzOUW5
HuT78 M2jwT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY[xNEDPxE1? M3zJc|czKGh? MmHsSG1UVw>? M17I[YRw\XNibn;0JIlv\HWlZTDhdI9xfG:|aYO= MkTRNlI5ODF7NUm=
MJ MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MonQNVAh|ryP MofiO|IhcA>? MmHVSG1UVw>? MXLkc4V{KG6xdDDpcoR2[2ViYYDvdJRwe2m| MWqyNlgxOTl3OR?=
DERL7 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2D3fVExKM7:TR?= NUDt[mRuPzJiaB?= MUTEUXNQ M3fZToRw\XNibn;0JIlv\HWlZTDhdI9xfG:|aYO= NELFXpQzOjhyMUm1PS=>
L1236 MmXSSpVv[3Srb36gRZN{[Xl? NXrXPHRWOTBizszN NHHKeZkzKGh? NWSyWJR2UW6qaXLpeIlwdiCxZjDBb5QheGixc4Doc5J6dGG2aX;u NX;FOWl7OjJ{MUC4O|c>
L428 MoTDSpVv[3Srb36gRZN{[Xl? NXzzd3F4OTBizszN NH3YeXkzKGh? M1PXRmlvcGmkaYTpc44hd2ZiQXv0JJBpd3OyaH;yfYxifGmxbh?= NH;QS3kzOjJzMEi3Oy=>
L591 MWLGeY5kfGmxbjDBd5NigQ>? NInoWW0yOCEQvF2= NX7hUVd2OiCq NIq4XJlKdmirYnn0bY9vKG:oIFHreEBxcG:|cHjvdplt[XSrb36= MX:yNlIyODh5Nx?=
KMH-2 MVnGeY5kfGmxbjDBd5NigQ>? M2TwcFExKM7:TR?= M2nuT|IhcA>? MmjYTY5pcWKrdHnvckBw\iCDa4SgdIhwe3Cqb4L5cIF1cW:w MYmyNlIyODh5Nx?=
L1236 NWTqb4I{TnWwY4Tpc44hSXO|YYm= NHnjXJA2KM7:TR?= M3rYTVI1KGh? NFrZfZRDdG:la4Ogd4VkemW2aX;uJI9nKHSqZTDDR2w2 NULQdmxvOjJ{MUC4O|c>
L591 M{H1dGZ2dmO2aX;uJGF{e2G7 M2Kz[|Uh|ryP NIfpZnczPCCq NYnkRml[SmyxY3vzJJNm[3KndHnvckBw\iC2aHWgR2NNPQ>? MlPiNlIzOTB6N{e=
L1236 MYjBdI9xfG:|aYOgRZN{[Xl? M3T1V|Uh|ryP Ml;KNlQhcA>? M1jWSWlv\HWldHnvckBw\iCjcH;weI9{cXN? NGXQWnYzOjJzMEi3Oy=>
L591 Mni4RZBweHSxc3nzJGF{e2G7 NVTTUI04PSEQvF2= NIDSdoQzPCCq NEDNS3dKdmS3Y4Tpc44hd2ZiYYDvdJRwe2m| Ml\0NlIzOTB6N{e=
U-87MG NH;pVmZHfW6ldHnvckBCe3OjeR?= NEjIUYsyODBibl2= NX\0S2xyOjRiaB?= MV\EUXNQ Mn7qTY5pcWKrdHnvckBw\iBiY3XscEBucWe{YYTpc44> MmS3NlIxPzl4MEm=
SW1783 Ml3OSpVv[3Srb36gRZN{[Xl? NInib4oyODBibl2= NFW5d5czPCCq NHXTNlhFVVOR M3fLS2lvcGmkaYTpc44hd2ZiIHPlcIwhdWmpcnH0bY9v Mln0NlIxPzl4MEm=
U-87MG NHvt[HBHfW6ldHnvckBCe3OjeR?= NHzt[Gk2KM7:TR?= NYjTNFNqOjRiaB?= NEW0R|hFVVOR MlH2TY5pcWKrdHnvckBw\iCDa4SgdIhwe3Cqb4L5cIF1cW:wIIP1ZpN1[W62aXHscJk> NF3SNYEzOjB5OU[wPS=>
SW1783 M3XT[mZ2dmO2aX;uJGF{e2G7 NIC3Z4g2KM7:TR?= M3HYelI1KGh? MYTEUXNQ M2[4bmlvcGmkaYTpc44hd2ZiQXv0JJBpd3OyaH;yfYxifGmxbjDzeYJ{fGGwdHnhcIx6 NXzGeo5jOjJyN{m2NFk>
U-373MG M3zp[2Z2dmO2aX;uJGF{e2G7 MXy1JO69VQ>? NYrB[2xnOjRiaB?= NEPFfFBFVVOR NGn4XJNKdmirYnn0bY9vKG:oIFHreEBxcG:|cHjvdplt[XSrb36gd5Vje3SjboTpZYxtgQ>? MnSzNlIxPzl4MEm=
SK-MG3 M2T2W2Z2dmO2aX;uJGF{e2G7 MWm1JO69VQ>? NVvLfmpmOjRiaB?= MmrqSG1UVw>? MVLJcohq[mm2aX;uJI9nKEGtdDDwbI9{eGixconsZZRqd25ic4Xid5RidnSrYXzsfS=> NH7hSWkzOjB5OU[wPS=>
SU-DHL-5 M4flc2Z2dmO2aX;uJGF{e2G7 NFLpPGUyKM7:TR?= M3vLU|I1KGh? M4LVUWROW09? M2HseWlv\HWldHnvckBw\iCjcH;weI9{cXN? NFu3ZnAzODl3OU[wOi=>
WSU-NHL MkHYSpVv[3Srb36gRZN{[Xl? Mnu4NUDPxE1? NV;2R5B1OjRiaB?= MnzCSG1UVw>? M4jEPGlv\HWldHnvckBw\iCjcH;weI9{cXN? MU[yNFk2QTZyNh?=
CCRF-SB MYTGeY5kfGmxbjDBd5NigQ>? MVWxJO69VQ>? MXGyOEBp NVfrbpB[TE2VTx?= M4LV[Wlv\HWldHnvckBw\iCjcH;weI9{cXN? M4fDPFIxQTV7NkC2
INA-6 NV3UdpZNTnWwY4Tpc44hSXO|YYm= MkPNOUDPxE1? NVPt[4lpPiCq MoTLTY5pcWKrdHnvckBw\iCSSUPLM2FsfCCjbnSgSXJMKHCjdHj3ZZk> NHrGWoszODVyNUG1PC=>
LB NGDH[VdHfW6ldHnvckBCe3OjeR?= MUO1JO69VQ>? M1jjUFYhcA>? MV3Jcohq[mm2aX;uJI9nKFCLNFuvRYt1KGGwZDDFVmsheGG2aIfhfS=> NUHPR3E2OjB3MEWxOVg>

... Click to View More Cell Line Experimental Data

Protocol

Kinase Assay:[2]
+ Expand

PI3K assay:

PI3K assay is preformed on whole-cell lysates from CLL or normal B cells. A PI3K ELISA assay is performed. Briefly, whole-cell extracts are added to a mixture of PI(4,5)P2 substrate and reaction buffer containing adenosine triphosphate (ATP) and allowed to incubate at room temperature. The reaction is stopped by adding PI(3,4,5)P3 detector mixed with EDTA (ethylenediaminetetraacetic acid) and allowed to incubate at room temperature for 1 hour. After this time, the mixture is transferred from each well to a PI3K ELISA plate and allowed to incubate 1 hour. Plates are washed and then incubated with secondary detector for 30 minutes. Plates are washed again, and 3,3′,5,5′-tetramethylbenzidine solution is added for 5 minutes at which time H2SO4 is added to stop all reactions. Plates are read at 450 nm on a Labsystems 96-well plate reader.
Cell Research:[2]
+ Expand
  • Cell lines: CLL B cells or healthy volunteer T cells or NK cells
  • Concentrations: 0.01-100 μM
  • Incubation Time: 48 hours
  • Method: MTT assays are performed to determine cytotoxicity. 1 × 105 cells are incubated with CAL-101. MTT reagent is then added, and plates are incubated for an additional 20 hours before washing with protamine sulfate in phosphate-buffered saline. DMSO is added, and absorbance is measured by spectrophotometry at 540 nm in a Labsystems plate reader. Cell viability is also measured at various time points with the use of annexin/PI flow cytometry. Data are analyzed. At least 104 cells are counted for each sample. Results are expressed as the percentage of total positive cells over untreated control. Experiments examining caspase-dependent apoptosis included the addition of 100 μM Z-VAD. Experiments examining survival signals include the addition of 1 μg/mL CD40L, 800 U/mL IL-4, 50 ng/mL BAFF, 20 ng/mL TNF-α, or coculturing on fibronectin or stromal (HS-5 cell line) coated plates. Stromal coculture is done by plating a 75-cm2 flask (80%-100% confluent) per 6-well plate 24 hours before the addition of CLL cells.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 83 mg/mL warmed (199.79 mM)
Ethanol 23 mg/mL (55.36 mM)
Water Insoluble
In vivo Add solvents individually and in order:
30% PEG 400 (dissolve first)+0.5% Tween 80+5% Propylene glycol
30mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 415.42
Formula

C22H18FN7O

CAS No. 870281-82-6
Storage powder
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02457598 Recruiting B-cell Malignancies Gilead Sciences June 30, 2015 Phase 1
NCT02962401 Not yet recruiting Waldenstrom Macroglobulinemia French Innovative Leukemia Organisation January 2017 Phase 2
NCT02928510 Not yet recruiting Absence of Signs or Symptoms|B-Cell Non-Hodgkin Lymphoma|Digestive System Signs and Symptoms|Indolent Adult Non-Hodgkin Lymphoma|Recurrent B-Cell Non-Hodgkin Lymphoma|Recurrent Chronic Lymphocytic Leukemia|Recurrent Indolent Adult Non-Hodgkin Lymphoma|Recurrent Small Lymphocytic Lymphoma Jonsson Comprehensive Cancer Center|Gilead Sciences|National Cancer Institute (NCI) January 2017 --
NCT02968563 Recruiting Chronic Lymphocytic Leukemia Gilead Sciences|German CLL Study Group December 2016 Phase 2
NCT02639910 Recruiting Leukemia, Lymphocytic, Chronic, B-Cell|Chronic Lymphocytic Leukemia|Small Lymphocytic Lymphoma MorphoSys AG November 2016 Phase 2
NCT02970318 Recruiting Chronic Lymphocytic Leukemia Acerta Pharma BV September 2016 Phase 3

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    What is the recommended dose of CAL-101 and the route of administration for mouse studies?

  • Answer:

    According to the following paper, S2226 can be used by I.V. administration at the concentration of 40 mg/kg. http://www.ncbi.nlm.nih.gov.ezproxy.liv.ac.uk/pubmed/?term=PI3K%CE%B4+inhibition+reduces+TNF+secretion+and+neuroinflammation+in+a+mouse+cerebral+stroke+model

PI3K Signaling Pathway Map

PI3K Inhibitors with Unique Features

Related PI3K Products

Tags: buy Idelalisib (CAL-101, GS-1101) | Idelalisib (CAL-101, GS-1101) supplier | purchase Idelalisib (CAL-101, GS-1101) | Idelalisib (CAL-101, GS-1101) cost | Idelalisib (CAL-101, GS-1101) manufacturer | order Idelalisib (CAL-101, GS-1101) | Idelalisib (CAL-101, GS-1101) distributor
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID