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c-Met Hepatocyte Growth Factor Receptor

c-Met Inhibitors (19)

water-soluble

Cat.No. Product Name Information Product Citations Customer Reviews
S1068 Crizotinib (PF-02341066) PF-2341066 (Crizotinib) is a potent inhibitor of c-Met and ALK with IC50 of 11 nM and 24 nnM, respectivley.
S1111 Foretinib (GSK1363089, XL880) XL880 (GSK1363089, EXEL-2880) is an ATP-competitive inhibitor of MET and KDR with IC50 of 0.4 nM and 0.9 nM, respectively.
S1070 PHA-665752 PHA-665752 is a potent, selective and ATP-competitive c-Met inhibitor with IC50 of 9 nM.
S1080 SU11274 SU11274 is a selective Met inhibitor with IC50 of 10 nM.
S1094 PF-04217903 PF-04217903 is a selective ATP-competitive c-Met inhibitor with IC50 of 4.8 nM.
S7067 EMD 1214063 EMD 1214063 is a potent and selective c-Met inhibitor with IC50 of 6 nM.
S1119 XL-184 free base (Cabozantinib) XL184 (Cabozantinib) is a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM, respectively.
S1112 SGX-523 SGX-523 is a selective Met inhibitor with IC50 of 4 nM.
S1561 BMS 777607 BMS-777607 is a Met-related inhibitor for c-Met, Axl, Ron and Tyro3 with IC50 of 3.9 nM, 1.1 nM, 1.8 nM and 4.3 nM, respectively.
S2753 ARQ 197 (Tivantinib) ARQ-197 is a novel and selective human c-Met inhibitor with IC50 of 0.1 μM.
Cat.No. Product Name Information Product Citations Customer Reviews
S1114 JNJ-38877605 JNJ-38877605 is an ATP-competitive inhibitor of c-Met with IC50 of 4 nM.
S2788 INCB28060 INCB28060 is a novel, ATP-competitive inhibitor of c-MET with IC50 of 0.13 nM.
S1361 MGCD-265 MGCD-265 is a potent, multi-target and ATP-competitive inhibitor of c-Met, VEGFR1, VEGFR2, VEGFR3, Ron, and Tie2 with IC50 of 1 nM, 3 nM, 3 nM, 4 nM, 2 nM and 7 nM, respectively.
S2774 MK-2461 MK-2461 is a potent inhibitor of c-Met, Ron, Flt1/3, PDGFRβ, Mer and FGFR1/2/3 with IC50 of 2.5 nM, 7 nM, 10 nM/22 nM, 22 nM, 24 nM and 65 nM/39 nM/50 nM, respectively.
S1316 AMG-208 AMG-208 is a highly selective c-Met inhibitor with IC50 of 9.3 nM.
S2859 Golvatinib (E7050) E7050 is a dual c-Met and VEGFR-2 inhibitor with IC50 of 14 nM and 16 nM, respectively.
S2747 AMG458 AMG 458 is a potent c-Met inhibitor of human c-Met and mouse c-Met with Ki of 1.2 nM or 2.0 nM.
S2201 BMS 794833 BMS794833 is a potent ATP competitive inhibitor of Met and VEGFR2 with IC50 of 1.7 nM and 15 nM, respectively.
S2761 NVP-BVU972 NVP-BVU972 is a selective and potent Met inhibitor with IC50 of 14 nM.
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All c-Met Inhibitors
Tags: c-Met inhibition | c-Met cancer | c-Met pathway | c-Met activation | c-Met phosphorylation | c-Met inhibitor clinical trial | c-Met assay | c-Met inhibitor therapy | c-Met inhibitor review