Home Protein Tyrosine Kinase c-Met inhibitor - VEGFR inhibitor - Axl inhibitor Ningetinib For research use only.

Ningetinib

Synonyms: CT-053, DE-120, CT053PTSA

Ningetinib (CT-053, DE-120, CT053PTSA) is a potent, orally bioavailable inhibitor of tyrosine kinase with IC50 of 6.7 nM, 1.9 nM and <1.0 nM for c-Met, VEGFR2 and Axl, respectively. Ningetinib exhibits antitumor activity.

Ningetinib Chemical Structure

Ningetinib Chemical Structure

CAS: 1394820-69-9

Purity & Quality Control

Batch: S687001 DMSO] 20 mg/mL] false] Water] Insoluble] false] Ethanol] Insoluble] false Purity: 99.82%
99.82

Ningetinib Related Products

Signaling Pathway

c-Met Signaling Pathways

c-Met Signaling Pathway

Choose Selective c-Met Inhibitors

Biological Activity

Description Ningetinib (CT-053, DE-120, CT053PTSA) is a potent, orally bioavailable inhibitor of tyrosine kinase with IC50 of 6.7 nM, 1.9 nM and <1.0 nM for c-Met, VEGFR2 and Axl, respectively. Ningetinib exhibits antitumor activity.
Targets
Axl [1]
(Cell-free assay)		 VEGFR2 [1]
(Cell-free assay)		 c-Met [1]
(Cell-free assay)
1.0 nM 1.9 nM 6.7 nM
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04992858 Not yet recruiting
Advanced NSCLC
Sunshine Lake Pharma Co. Ltd.
 November 27 2022 Phase 2
NCT03975907 Recruiting
Multiple Myeloma
CARsgen Therapeutics Co. Ltd.|Beijing Chao Yang Hospital|The First Affiliated Hospital of Soochow University|Xinhua Hospital Shanghai Jiao Tong University School of Medicine|Tianjin Medical University General Hospital|First Affiliated Hospital of Zhejiang University|Beijing Hospital|Shanghai Tongji Hospital Tongji University School of Medicine|First Affiliated Hospital of Wenzhou Medical University|Xiangya Hospital of Central South University|Peking University People''s Hospital|Qilu Hospital of Shandong University|Sun Yat-sen University|First Affiliated Hospital Sun Yat-Sen University
 June 10 2019 Phase 1|Phase 2
NCT04577703 Completed
Advanced Solid Tumors
Sunshine Lake Pharma Co. Ltd.
 February 8 2014 Phase 1
NCT02022501 Completed
Age-Related Macular Degeneration
Santen Inc.
 January 2014 Phase 1|Phase 2

Chemical Information & Solubility

Molecular Weight 556.58 Formula

C31H29FN4O5
CAS No. 1394820-69-9 SDF --
Smiles CC1=C(C(=O)N(N1C)C2=CC=CC=C2)C(=O)NC3=CC(=C(C=C3)OC4=C5C=CC(=CC5=NC=C4)OCC(C)(C)O)F
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 20 mg/mL ( (35.93 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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In vivo Formulation Calculator

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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