MNK-45 |
Kinase assay |
~10 μM |
|
|
inhibits c-Met phosphorylation and downstream c-Met signaling pathways |
|
HT29 |
Kinase assay |
~10 μM |
|
|
inhibits c-Met phosphorylation and downstream c-Met signaling pathways |
|
MDA-MB-231 |
Kinase assay |
~10 μM |
|
|
inhibits c-Met phosphorylation and downstream c-Met signaling pathways |
|
NCI-H441 |
Kinase assay |
~10 μM |
|
|
inhibits c-Met phosphorylation and downstream c-Met signaling pathways |
|
SK-MEL-28 |
Growth inhibitory assay |
33 μM |
|
|
IC50>33 μM |
|
NCI-H661 |
Growth inhibitory assay |
33 μM |
|
|
IC50>33 μM |
|
NCI-H446 |
Growth inhibitory assay |
33 μM |
|
|
IC50=7 μM |
|
MDA-MB-231 |
Growth inhibitory assay |
33 μM |
|
|
IC50=0.55 μM |
|
DLD-1 |
Growth inhibitory assay |
33 μM |
|
|
IC50=0.53 μM |
|
A549 |
Growth inhibitory assay |
33 μM |
|
|
IC50=0.59 μM |
|
SK-OV-3 |
Growth inhibitory assay |
33 μM |
|
|
IC50=0.66 μM |
|
NCI-H460 |
Growth inhibitory assay |
33 μM |
|
|
IC50=0.6 μM |
|
A375 |
Growth inhibitory assay |
33 μM |
|
|
IC50=0.42 μM |
|
NCI-H441 |
Growth inhibitory assay |
33 μM |
|
|
IC50=0.3 μM |
|
HT29 |
Growth inhibitory assay |
33 μM |
|
|
IC50=0.49 μM |
|
MKN-45 |
Growth inhibitory assay |
33 μM |
|
|
IC50=0.58 μM |
|
HT29 |
Apoptosis assay |
~10 μM |
|
|
significantly induces apoptosis by 80-90%. |
|
MKN-45 |
Apoptosis assay |
~10 μM |
|
|
significantly induces apoptosis by 80-90%. |
|
MDA-MB-231 |
Apoptosis assay |
~10 μM |
|
|
modestly induces apoptosis by 35%. |
|
MDA-MB-231/TGL |
Growth inhibitory assay |
~100 μM |
|
|
GI50=1.2 μM |
|
1833/TGL |
Growth inhibitory assay |
~100 μM |
|
|
GI50=3.7 μM |
|
EBC1 |
Cytotoxic assay |
~10 μM |
|
|
inhibits the cell growth. |
|
SNU638 |
Cytotoxic assay |
~10 μM |
|
|
inhibits the cell growth. |
|
A549 |
Cytotoxic assay |
~10 μM |
|
|
not affect |
|
H460 |
Cytotoxic assay |
~10 μM |
|
|
not affect |
|
HCC827 |
Cytotoxic assay |
~10 μM |
|
|
not affect |
|
A549 |
Function assay |
10 μM |
|
|
disrupts microtubule |
|
EBC1 |
Function assay |
10 μM |
|
|
disrupts microtubule |
|
H460 |
Function assay |
10 μM |
|
|
inhibits tubulin polymerization |
|
K562/VCR |
Cytotoxic assay |
~10 μM |
|
|
shows cytotoxic activity |
|
CEM/VBL |
Cytotoxic assay |
~10 μM |
|
|
shows cytotoxic activity |
|
U266 |
Cytotoxic assay |
~3 μM |
|
|
IC50=1.1 μM |
|
OPM-2 |
Cytotoxic assay |
~3 μM |
|
|
IC50=1.8 μM |
|
MM.1S |
Cytotoxic assay |
~3 μM |
|
|
IC50=1.6 μM |
|
MM.1R |
Growth inhibitory assay |
3 μM |
|
|
inhibits cell growth by 49% |
|
RPMI-8226 |
Cytotoxic assay |
~3 μM |
|
|
IC50=0.9 μM |
|
ANBL-6 |
Cytotoxic assay |
1 μM |
|
|
induces cell death by more than 50% |
|
ANLB-6/V10R |
Cytotoxic assay |
1 μM |
|
|
induces cell death by more than 50% |
|
KAS-6/1 |
Cytotoxic assay |
1 μM |
|
|
induces cell death by more than 50% |
|
KAS-6/V10R |
Cytotoxic assay |
1 μM |
|
|
induces cell death by more than 50% |
|
KAS-6/R10R |
Cytotoxic assay |
1 μM |
|
|
induces cell death by more than 50% |
|
8226/S |
Growth inhibitory assay |
3 μM |
|
|
inhibits cell growth by 54% |
|
8226/LR-5 |
Growth inhibitory assay |
3 μM |
|
|
inhibits cell growth by 54% |
|
Huh7 |
Cytotoxic assay |
~4.8 μM |
|
DMSO |
IC50=9.9 nM |
|
Hep3B |
Cytotoxic assay |
~4.8 μM |
|
DMSO |
IC50=448.7 nM |
|
HepG2 |
Cytotoxic assay |
~4.8 μM |
|
DMSO |
IC50=139.77 nM |
|
Chang |
Cytotoxic assay |
~4.8 μM |
|
DMSO |
IC50=448.7 nM |
|
Huh7 |
Function assay |
1.6 μM |
|
DMSO |
causes a G2/M cell cycle arrest |
|
Hep3B |
Function assay |
1.6 μM |
|
DMSO |
causes a G2/M cell cycle arrest |
|
HepG2 |
Function assay |
1.6 μM |
|
DMSO |
causes a G2/M cell cycle arrest |
|
Chang |
Function assay |
1.6 μM |
|
DMSO |
causes a G2/M cell cycle arrest |
|
MHCC97L |
Growth inhibitory assay |
~10 μM |
|
DMSO |
IC50=315 nM |
|
MHCC97H |
Growth inhibitory assay |
~10 μM |
|
DMSO |
IC50=368 nM |
|
Huh7 |
Growth inhibitory assay |
~10 μM |
|
DMSO |
IC50=265 nM |
|
HepG2 |
Growth inhibitory assay |
~10 μM |
|
DMSO |
IC50=392 nM |
|
MHCC97L |
Function assay |
1 μM |
|
DMSO |
induces microtubules depolymerization |
|
Huh7 |
Function assay |
1 μM |
|
DMSO |
induces microtubules depolymerization |
|
MHCC97L |
Apoptosis assay |
1 μM |
|
DMSO |
induces apoptosis |
|
Huh7 |
Apoptosis assay |
1 μM |
|
DMSO |
induces apoptosis |
|
C3H 10T1/2 mouse fibroblasts |
Kinase assay |
25 μM |
|
DMSO |
reduces Histone H3 and H4 acetylation levels |
|
H23 |
Growth inhibitory assay |
25 μM |
|
DMSO |
significantly inhibits cell growth. |
|
WM35 |
Growth inhibitory assay |
10 μM |
|
DMSO |
significantly inhibits cell growth. |
|
NIH 3T3 |
Growth inhibitory assay |
10 μM |
|
DMSO |
does not have a significant inhibitory effect |
|
H838 |
Growth inhibitory assay |
10 μM |
|
DMSO |
does not have a significant inhibitory effect |
|
H1395 |
Growth inhibitory assay |
10 μM |
|
DMSO |
does not have a significant inhibitory effect |
|
Quiescent S2 |
Kinase assay |
30 μM |
|
DMSO |
completely abrogates TSA-induced hyperacetylation of H3K4me3 histones |
|
PC3 |
Apoptosis assay |
20 μM |
|
DMSO |
induces apoptosis |
|
Du145 |
Apoptosis assay |
20 μM |
|
DMSO |
induces apoptosis |
|
LNCaP |
Apoptosis assay |
20 μM |
|
DMSO |
induces apoptosis |
|
LAPC-4 |
Apoptosis assay |
20 μM |
|
DMSO |
induces apoptosis |
|
LNCaP |
Function assay |
20 μM |
|
DMSO |
decreases PSA secretion and p65 expression levels |
|
LAPC-4 |
Function assay |
20 μM |
|
DMSO |
decreases PSA secretion and p65 expression levels |
|
Kasumi-1 |
Growth inhibitory assay |
~50 μM |
|
DMSO |
inhibits cell proliferation |
|
SKNO-1 |
Growth inhibitory assay |
~50 μM |
|
DMSO |
inhibits cell proliferation |
|
Kasumi-1 |
Kinase assay |
~10 μM |
|
DMSO |
reduces expression of acetylated histone H3, c-kit and bcl-2 |
|
SKNO-1 |
Kinase assay |
~10 μM |
|
DMSO |
reduces expression of acetylated histone H3, c-kit and bcl-2 |
|
A549 |
Function assay |
10 μM |
|
DMSO |
enhances mitotic catastrophe |
|
NRK-52E |
Function assay |
10 μM |
|
DMSO |
inhibits Ang II-induced STAT3 nuclear translocation and the expression of TGF-β1, collagen IV and fibronectin |
|
PC12 |
Growth inhibitory assay |
~12.5 μM |
|
DMSO |
prevents TSA-induced neurite formation |
|
HPMCs |
Function assay |
|
|
|
reverses epithelial to mesenchymal transition of human peritoneal mesothelial cells |
|
A549 |
Function assay |
~50 μM |
|
DMSO |
affects the viral life cycle and host response |
|
RAW264.7 |
Function assay |
~30 μM |
|
DMSO |
reduces pro-inflammatory gene expression |
|
MEMM |
Kinase assay |
15 µM |
|
DMSO |
decreases acetylation of histone H3 |
|
MEMM |
Growth inhibitory assay |
~20 µM |
|
DMSO |
inhibits cell proliferation |
|
MEMM |
Apoptosis assay |
15 µM |
|
DMSO |
induces the presence of the apoptosis protein, cleaved Caspase-3 |
|
T47D |
Growth inhibitory assay |
10 μM |
|
DMSO |
IC50=72 nM |
|
ZR-75-1 |
Growth inhibitory assay |
10 μM |
|
DMSO |
IC50=79 nM |
|
BT474 |
Growth inhibitory assay |
10 μM |
|
DMSO |
IC50=86 nM |
|
HCC1954 |
Growth inhibitory assay |
10 μM |
|
DMSO |
IC50=119 nM |
|
MDA-MB-453 |
Growth inhibitory assay |
10 μM |
|
DMSO |
IC50=975 nM |
|
MDA-MB-468 |
Growth inhibitory assay |
10 μM |
|
DMSO |
IC50=3208 nM |
|
SkBr3 |
Growth inhibitory assay |
10 μM |
|
DMSO |
IC50>10,000 nM |
|
MDA-MB-231 |
Growth inhibitory assay |
10 μM |
|
DMSO |
IC50>10,000 nM |
|
HCT116 |
Growth inhibitory assay |
10 μM |
|
DMSO |
IC50=5836 nM |
|
HT29 |
Growth inhibitory assay |
10 μM |
|
DMSO |
IC50>10,000 nM |
|
HFF |
Growth inhibitory assay |
10 μM |
|
DMSO |
IC50=7615 nM |
|
HN5 |
Growth inhibitory assay |
10 μM |
|
DMSO |
IC50>10,000 nM |
|
786-0 |
Growth inhibitory assay |
10 μM |
|
DMSO |
IC50=4009 nM |
|
H157 |
Growth inhibitory assay |
10 μM |
|
DMSO |
IC50=2642 nM |
|
NCI-H460 |
Growth inhibitory assay |
10 μM |
|
DMSO |
IC50>2,500 nM |
|
SKOV-3 |
Growth inhibitory assay |
10 μM |
|
DMSO |
IC50=2126 nM |
|
OVCAR-3 |
Growth inhibitory assay |
10 μM |
|
DMSO |
IC50=2918 nM |
|
BXPC3 |
Growth inhibitory assay |
10 μM |
|
DMSO |
IC50=3141 nM |
|
MiaPaCa |
Growth inhibitory assay |
10 μM |
|
DMSO |
IC50=5433 nM |
|
PANC-1 |
Growth inhibitory assay |
10 μM |
|
DMSO |
IC50=8681 nM |
|
LNCaP |
Growth inhibitory assay |
10 μM |
|
DMSO |
IC50=147 nM |
|
DU145 |
Growth inhibitory assay |
10 μM |
|
DMSO |
IC50=3812 nM |
|
PC3 |
Growth inhibitory assay |
10 μM |
|
DMSO |
IC50>10,000 nM |
|
BT474 |
Kinase assay |
10 μM |
|
DMSO |
inhibits pGSK3β with IC50 of 160 nM |
|
786-0 |
Kinase assay |
10 μM |
|
DMSO |
inhibits pGSK3β with IC50 of 150 nM |
|
LNCaP |
Kinase assay |
10 μM |
|
DMSO |
inhibits pGSK3β with IC50 of 43 nM |
|
PC3 |
Kinase assay |
10 μM |
|
DMSO |
inhibits pGSK3β with IC50 of 49 nM |
|
KARPAS-231 |
Growth inhibitory assay |
10 μM |
|
DMSO |
EC50=41 nM |
|
CCRFSB |
Growth inhibitory assay |
10 μM |
|
DMSO |
EC50=155 nM |
|
SUP B15 |
Growth inhibitory assay |
10 μM |
|
DMSO |
EC50=197 nM |
|
SD-1 |
Growth inhibitory assay |
10 μM |
|
DMSO |
EC50=320 nM |
|
RS4;11 |
Growth inhibitory assay |
10 μM |
|
DMSO |
EC50=654 nM |
|
MN-60 |
Growth inhibitory assay |
10 μM |
|
DMSO |
EC50=3602 nM |
|
Tanoue |
Growth inhibitory assay |
10 μM |
|
DMSO |
EC50=4517 nM |
|
RCH-ACV |
Growth inhibitory assay |
10 μM |
|
DMSO |
EC50=152 nM |
|
SEM |
Growth inhibitory assay |
10 μM |
|
DMSO |
EC50=202 nM |
|
KASUMI-2 |
Growth inhibitory assay |
10 μM |
|
DMSO |
EC50=225 nM |
|
REH |
Growth inhibitory assay |
10 μM |
|
DMSO |
EC50=288 nM |
|
697 |
Growth inhibitory assay |
10 μM |
|
DMSO |
EC50=338 nM |
|
NALM-6 |
Growth inhibitory assay |
10 μM |
|
DMSO |
EC50=421 nM |
|
MHH-CALL–3 |
Growth inhibitory assay |
10 μM |
|
DMSO |
EC50=812 nM |
|
MHH-CALL–2 |
Growth inhibitory assay |
10 μM |
|
DMSO |
EC50=2114 nM |
|
J.GAMMA-1 |
Growth inhibitory assay |
10 μM |
|
DMSO |
EC50=65 nM |
|
JR45.01 |
Growth inhibitory assay |
10 μM |
|
DMSO |
EC50=68 nM |
|
A3 |
Growth inhibitory assay |
10 μM |
|
DMSO |
EC50=69 nM |
|
I 2.1 |
Growth inhibitory assay |
10 μM |
|
DMSO |
EC50=73 nM |
|
MOLT-3 |
Growth inhibitory assay |
10 μM |
|
DMSO |
EC50=74 nM |
|
P116 |
Growth inhibitory assay |
10 μM |
|
DMSO |
EC50=78 nM |
|
J.Cam1.6 |
Growth inhibitory assay |
10 μM |
|
DMSO |
EC50=79 nM |
|
I 9.2 |
Growth inhibitory assay |
10 μM |
|
DMSO |
EC50=80 nM |
|
LOUCY |
Growth inhibitory assay |
10 μM |
|
DMSO |
EC50=117 nM |
|
J.RT3-T3.5 |
Growth inhibitory assay |
10 μM |
|
DMSO |
EC50=123 nM |
|
800000 |
Growth inhibitory assay |
10 μM |
|
DMSO |
EC50=163 nM |
|
Jurkat |
Growth inhibitory assay |
10 μM |
|
DMSO |
EC50=225 nM |
|
MOLT-4 |
Growth inhibitory assay |
10 μM |
|
DMSO |
EC50=232 nM |
|
Molt-16 |
Growth inhibitory assay |
10 μM |
|
DMSO |
EC50=241 nM |
|
CEM/C3 |
Growth inhibitory assay |
10 μM |
|
DMSO |
EC50=257 nM |
|
CEM/C2 |
Growth inhibitory assay |
10 μM |
|
DMSO |
EC50=271 nM |
|
CCRFCEM |
Growth inhibitory assay |
10 μM |
|
DMSO |
EC50=327 nM |
|
CEM/C1 |
Growth inhibitory assay |
10 μM |
|
DMSO |
EC50=382 nM |
|
SUPTI[VB] |
Growth inhibitory assay |
10 μM |
|
DMSO |
EC50=619 nM |
|
CCRF–HSB-2 |
Growth inhibitory assay |
10 μM |
|
DMSO |
EC50=2117 nM |
|
I 2.1 |
Apoptosis assay |
10 μM |
|
DMSO |
induces apoptosis |
|
I 9.2 |
Apoptosis assay |
10 μM |
|
DMSO |
induces apoptosis |
|
A3 |
Apoptosis assay |
10 μM |
|
DMSO |
induces apoptosis |
|
RD |
Growth inhibitory assay |
10 μM |
|
|
IC50>10 μM |
|
Rh41 |
Growth inhibitory assay |
10 μM |
|
|
IC50=33.8 nM |
|
Rh18 |
Growth inhibitory assay |
10 μM |
|
|
IC50=303 nM |
|
Rh30 |
Growth inhibitory assay |
10 μM |
|
|
IC50=4.81 μM |
|
BT-12 |
Growth inhibitory assay |
10 μM |
|
|
IC50>10 μM |
|
CHLA-266 |
Growth inhibitory assay |
10 μM |
|
|
IC50=1.22 μM |
|
TC-71 |
Growth inhibitory assay |
10 μM |
|
|
IC50=2.52 μM |
|
CHLA-9 |
Growth inhibitory assay |
10 μM |
|
|
IC50=591 nM |
|
CHLA-10 |
Growth inhibitory assay |
10 μM |
|
|
IC50=102 nM |
|
CHLA-258 |
Growth inhibitory assay |
10 μM |
|
|
IC50=1.05 μM |
|
GBM2 |
Growth inhibitory assay |
10 μM |
|
|
IC50=9.15 μM |
|
NB-1643 |
Growth inhibitory assay |
10 μM |
|
|
IC50=5.4 μM |
|
NB-Ebc1 |
Growth inhibitory assay |
10 μM |
|
|
IC50>10 μM |
|
CHLA-90 |
Growth inhibitory assay |
10 μM |
|
|
IC50>10 μM |
|
CHLA-136 |
Growth inhibitory assay |
10 μM |
|
|
IC50>10 μM |
|
NALM-6 |
Growth inhibitory assay |
10 μM |
|
|
IC50=265 nM |
|
COG-LL-317 |
Growth inhibitory assay |
10 μM |
|
|
IC50=6.49 nM |
|
RS4;11 |
Growth inhibitory assay |
10 μM |
|
|
IC50=147 nM |
|
MOLT-4 |
Growth inhibitory assay |
10 μM |
|
|
IC50=40 nM |
|
CCRF-CEM |
Growth inhibitory assay |
10 μM |
|
|
IC50=268 nM |
|
Kasumi-1 |
Growth inhibitory assay |
10 μM |
|
|
IC50=107 nM |
|
Karpas-299 |
Growth inhibitory assay |
10 μM |
|
|
IC50=2.93 μM |
|
Ramos-RA1 |
Growth inhibitory assay |
10 μM |
|
|
IC50=7.35 μM |
|
H1299 |
Kinase assay |
10 μM |
|
|
inhibits IKBKE-induced Akt Activation |
|