Research Area
Product Type
United States ( Change Country )
PF-04217903 Chemical Structure
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Biological Activity
PF-04217903 is an orally bioavailabe, small-molecule MET tyrosine kinase inhibitor with potential antineoplastic activity. [1]
PF-04217903 demonstrates exquisite kinase selectivity. Inhibition studies of the c-Met mutants show that PF-04217903 is more susceptible to oncogenic mutations that attenuate potency than PF-02341066. [1]
PF-04217903 was evaluated against multiple kinase selectivity screening panels: Invitrogen Inc. (125 kinases), Millipore/Upstate Ltd. (105 kinases), University ofDundee (51 kinases), and Pfizer in-house (48 kinases) (Supporting Information). On the basis of the percent inhibition or IC50 values generated from each of these screens, PF-04217903 was estimated to be>1000-fold selective for c-Met compared with each of the other kinases included in these collective screening assays. [1]
References on PF-04217903
- [1] Biochemistry 2009;48:5339–5349
Chemical Information
| Molecular Weight (WM): | 372.38 |
|---|---|
| Formula: | C19H16N8O |
| CAS No.: | 956905-27-4 |
| Synonyms: |
N/A
|
| Dissolve in (25°C): | DMSO ≥75mg/mL |
| Water <1mg/mL | |
| Ethanol <1mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
Quality Control & MSDS
Research Area
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Western blot analysis of c-Met, MAPK and Akt. 0-100nM PF04217903 was added.
Western blot analysis of c-Met, MAPK and Akt. 0-100nM PF04217903 was added.
Data independently produced by Dr. Zhang of Tianjin Medical University PF-04217903 purchased from Selleck
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Western blot analysis of c-Met, MAPK and Akt. 0-100nM PF04217903 was added.
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Data independently produced by Dr. Zhang of Tianjin Medical University
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