Research Area
Product Type
United States ( Change Country )
SU11274 Chemical Structure
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Biological Activity
SU11274 is a highly specific inhibitor of c-Met , with in vitro IC50 for the Met enzyme at 0.012 μmol/L. The inhibitor did not affect other tyrosine kinase oncoproteins, including BCR-ABL, TEL-JAK2, TEL-PDGF_R, or TEL-ABL. Inhibition of the Met kinase activity by SU11274 led to time- and dose-dependent reduced cell growth. [1]
Further study shows SU11274 belongs to a class of small molecule RTK inhibitors that exert their activity by competing for the Mg-ATP complex binding pocket, which results in inhibition of kinase activity and subsequent downstream signaling. [2]
References on SU11274
- [1] Oncogene 2004;23:5387–5393
- [2] Cancer Res 2005;65:1479-1488
Chemical Information
| Molecular Weight (WM): | 568.09 |
|---|---|
| Formula: | C28H30CIN5O4S |
| CAS No.: | 658084-23-2 |
| Synonyms: |
N/A
|
| Dissolve in (25°C): | DMSO ≥92mg/mL |
| Water <1mg/mL | |
| Ethanol ≥2mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
Quality Control & MSDS
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Western blot analysis of c-Met, MAPK and Akt. 0-20μM SU11724 was added.
Western blot analysis of c-Met, MAPK and Akt. 0-20μM SU11724 was added.
Data independently produced by Dr. Zhang of Tianjin Medical University SU11274 purchased from Selleck
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Western blot analysis of c-Met, MAPK and Akt. 0-20μM SU11724 was added.
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Data independently produced by Dr. Zhang of Tianjin Medical University
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