Home Neuronal Signaling GABA Receptor agonist (R)-baclofen For research use only.

(R)-baclofen

Synonyms: STX 209

(R)-baclofen (STX 209) is a derivative of gamma-aminobutyric acid primarily used to treat spasticity.

(R)-baclofen Chemical Structure

(R)-baclofen Chemical Structure

CAS: 69308-37-8

Selleck's (R)-baclofen has been cited by 1 publication

Purity & Quality Control

Batch: S307201 Water] 8 mg/mL] false] DMSO] Insoluble] false] Ethanol] Insoluble] false Purity: 99.72%
99.72

(R)-baclofen Related Products

Signaling Pathway

GABA Receptor Signaling Pathways

GABA Receptor Signaling Pathway

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Biological Activity

Description (R)-baclofen (STX 209) is a derivative of gamma-aminobutyric acid primarily used to treat spasticity.
Targets
GABAB receptor [1]
In vitro
In vitro Baclofen is a skeletal muscle relaxant used in the treatment of spasticity of spinal and cerebral origin. Although it is marketed as a racemic mixture, only the baclofen R-enantiomer is stereospecifically active at so called GAGAB-receptors. [1] Researchers believe that the enantiomers of baclofen have different properties. It is claimed that the R-(−)-enantiomer is about 100 times more active than the S-(+)-enantiomer.

Chemical Information & Solubility

Molecular Weight 213.66 Formula

C10H12ClNO2
CAS No. 69308-37-8 SDF Download (R)-baclofen SDF
Smiles C1=CC(=CC=C1C(CC(=O)O)CN)Cl
Storage (From the date of receipt)

In vitro
Batch:

Water : 8 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble


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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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