(R)-baclofen

Catalog No.S3072 Synonyms: STX 209

(R)-baclofen Chemical Structure

Molecular Weight(MW): 213.66

(R)-baclofen is a derivative of gamma-aminobutyric acid primarily used to treat spasticity.

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Biological Activity

Description (R)-baclofen is a derivative of gamma-aminobutyric acid primarily used to treat spasticity.
Targets
GABAB receptor [1]
In vitro

Baclofen is a skeletal muscle relaxant used in the treatment of spasticity of spinal and cerebral origin. Although it is marketed as a racemic mixture, only the baclofen R-enantiomer is stereospecifically active at so called GAGAB-receptors. [1] Researchers believe that the enantiomers of baclofen have different properties. It is claimed that the R-(−)-enantiomer is about 100 times more active than the S-(+)-enantiomer.

Protocol

Solubility (25°C)

In vitro Water 8 mg/mL (37.44 mM)
DMSO Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 213.66
Formula

C10H12ClNO2

CAS No. 69308-37-8
Storage powder
Synonyms STX 209

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Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
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