Valproic acid sodium salt (Sodium valproate)

Valproic acid sodium salt (Sodium valproate) is a HDAC inhibitor with IC50 of 0.4 mM and also inhibits GABA-transaminase or succinic semialdehyde dehydrogenase.

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In DMSO USD 420 In stock
USD 97 In stock
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Valproic acid sodium salt (Sodium valproate) Chemical Structure

Valproic acid sodium salt (Sodium valproate) Chemical Structure
Molecular Weight: 166.19

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Customer Reviews(1)

Related Compound Libraries

Valproic acid sodium salt (Sodium valproate) is available in the following compound libraries:

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Product Description

Biological Activity

Valproic acid sodium salt (Sodium valproate) is a histone deacetylase inhibitor with an IC50 of 0.4 mM and exhibits anticancer, anti-inflammatory and neuroprotective effects. Sodium valproate (VPA) can inhibit the proliferation of tumor cells by inducing G0/G1 phase arrest and cell apoptosis. It displays anticonvulsive activity via an increase in GABA levels and decreases Aβ production in animal models of Alzheimer’s disease. It also attenuates NMDA-mediated excitation, blocks voltage-gated Na+ channels and modulates firing of neurons. It enables induction of pluripotent stem cells from somatic cells by Oct4 and Sox2. [1][2][3]

Clinical Trial Information( data from http://clinicaltrials.gov)

NCT Number Recruitment Conditions Sponsor
/Collaborators
Start Date Phases
NCT00228046 Completed Attention Deficit Disorder With Hyperactivity|Conduct Disorder|Oppositional Defiant Disorder Stony Brook University|National Institute of Mental Health (NIMH) 2004-01 Phase 4
NCT00431522 Completed Bipolar Disorder Sanofi 2004-12 Phase 4

Chemical Information

Download Valproic acid sodium salt (Sodium valproate) SDF
Molecular Weight (MW) 166.19
Formula

C8H15NaO2

CAS No. 1069-66-5
Storage 3 years -20℃Powder
6 months-80℃in DMSO
Synonyms
Solubility (25°C) * In vitro DMSO 33 mg/mL (198 mM)
Water 33 mg/mL (198 mM)
Ethanol 33 mg/mL (198 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Name sodium 2-propylpentanoate

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Customer Reviews (1)


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Rating
Source Dr. Zhang of Tianjin Medical University. Valproic acid sodium salt (Sodium valproate) purchased from Selleck
Method Western blot
Cell Lines
Concentrations 0-10 μM
Incubation Time
Results Increased Histone acetylation in cells treated with Sodium valproate was observed.

Product Citations (1)

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