Home Neuronal Signaling GABA Receptor modulator Homotaurine For research use only.

Homotaurine

Synonyms: Tramiprosate, Alzhemed, 3-Amino-1-propanesulfonic acid

Homotaurine (Tramiprosate, Alzhemed, 3-Amino-1-propanesulfonic acid) is a synthetic organic compound that has GABAergic activity by mimicking GABA. It is a GABAA partial agonist as well as a GABAB receptor partial agonist with low efficacy.

Homotaurine Chemical Structure

Homotaurine Chemical Structure

CAS: 3687-18-1

Purity & Quality Control

Batch: S513101 Water] 27 mg/mL] false] DMSO] Insoluble] false] ] ] false Purity: 98%
98

Homotaurine Related Products

Signaling Pathway

GABA Receptor Signaling Pathways

GABA Receptor Signaling Pathway

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Biological Activity

Description Homotaurine (Tramiprosate, Alzhemed, 3-Amino-1-propanesulfonic acid) is a synthetic organic compound that has GABAergic activity by mimicking GABA. It is a GABAA partial agonist as well as a GABAB receptor partial agonist with low efficacy.
Targets
GABA receptor [1]
In vitro
In vitro Homotaurine is a small aminosulfonate compound naturally found in seaweeds. It is a compound with features typical of glycosaminoglycanes (GAGs). Homotaurine has been shown to be able to counteract Aβ fibrillogenesis reducing the toxic effects on neurons. Besides the anti-amyloid action, homotaurine has direct effects also on neuronal activity as a modulator of excitatory neurotransmission, due to its binding affinity for GABAA receptors (GABAARs)[1].
Cell Research Cell lines Retinal cells
Concentrations 1 μM, 10 μM, and 100 μM
Incubation Time 24 hours
Method

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In Vivo
In vivo In experimental models homotaurine administration induced inhibition of Aβ fibrils formation, reduction of the brain pathologic burden, and formation of physiological LTP[1].
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04422743 Terminated
Glaucoma
IRCCS Policlinico S. Matteo
 January 25 2018 Not Applicable
NCT04157712 Completed
Alzheimer Disease
Alzheon Inc.|Quotient Clinical
 September 26 2015 Phase 1
NCT00314912 Unknown status
Alzheimer''s Disease
Bellus Health Inc. - a GSK company
 May 2006 Phase 3

Chemical Information & Solubility

Molecular Weight 139.17 Formula

C3H9NO3S
CAS No. 3687-18-1 SDF Download Homotaurine SDF
Smiles C(CN)CS(=O)(=O)O
Storage (From the date of receipt)

In vitro
Batch:

Water : 27 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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