Catalog No.S4274

Rotigotine is a dopamine receptor agonist, used in the treatment of Parkinson's disease and restless legs syndrome.

Price Stock Quantity  
USD 97 In stock
USD 377 In stock
USD 847 In stock
Bulk Inquiry

Massive Discount Available

Free Overnight Delivery on all orders over $ 500.

Rotigotine Chemical Structure

Rotigotine Chemical Structure
Molecular Weight: 315.47

Validation & Quality Control

Quality Control & MSDS

Related Compound Libraries

Rotigotine is available in the following compound libraries:

Product Information

  • Compare Dopamine Receptor Chemicals
    Compare Dopamine Receptor Products
  • Research Area

Product Description

Biological Activity

Description Rotigotine is a dopamine receptor agonist, used in the treatment of Parkinson's disease and restless legs syndrome.
Targets Dopamine receptor [1]
In vitro
In vivo

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDog
Weight (kg)
Body Surface Area (m2)0.0070.0250.
Km factor36128520
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)


Clinical Trial Information( data from, updated on 2016-07-30)

NCT Number Recruitment Conditions Sponsor
Start Date Phases
NCT02728947 Recruiting Parkinsons Disease Luye Pharma Group Ltd. May 2016 Phase 1
NCT02365870 Not yet recruiting Anxiety Disorders|Parkinson Disease Johns Hopkins University|National Institute on Aging (NIA) May 2015 Phase 4
NCT02230904 Completed Parkinsons Disease UCB BIOSCIENCES GmbH|Pharmaceutical Health Sciences|Brack  ...more UCB BIOSCIENCES GmbH|Pharmaceutical Health Sciences|Bracket Global|UCB Pharma September 2014 Phase 1
NCT01976871 Active, not recruiting Restless Legs Syndrome|Ekbom Syndrome|Willis-Ekbom Disease John Winkelman, MD, PhD|Massachusetts General Hospital August 2014 Phase 4
NCT02070796 Completed Healthy UCB Pharma SA|UCB Pharma February 2014 Phase 1

view more

Chemical Information

Download Rotigotine SDF
Molecular Weight (MW) 315.47


CAS No. 99755-59-6
Storage 3 years -20℃powder
2 years -80℃in solvent
Synonyms N/A
Solubility (25°C) * In vitro DMSO 63 mg/mL (199.7 mM)
Ethanol 63 mg/mL (199.7 mM)
Water <1 mg/mL
In vivo
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Name 5,6,7,8-tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-(6S)-1-naphthalenol

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

* Indicates a Required Field

Related Dopamine Receptor Products

  • AZD3839

    AZD3839 is a potent and selective BACE1 inhibitor with Ki of 26.1 nM, about 14-fold selectivity over BACE2. Phase 1.

  • Xanthohumol

    Xanthohumol, a prenylated chalcone from hop, inhibits COX-1 and COX-2 activity and shows chemopreventive effects. Phase 1.

  • A-438079 HCl

    A-438079 HCl is a potent, and selective P2X7 receptor antagonist with pIC50 of 6.9.

  • Chlorpromazine HCl

    Chlorpromazine HCl is a dopamine and potassium channel inhibitor with IC50 of 6.1 and 16 μM for inward-rectifying K+ currents and time-independent outward currents.

  • Chlorprothixene

    Chlorprothixene has strong binding affinities to dopamine and histamine receptors, such as D1, D2, D3, D5, H1, 5-HT2, 5-HT6 and 5-HT7, with Ki of 18 nM, 2.96 nM, 4.56 nM, 9 nM, 3.75 nM, 9.4 nM, 3 nM and 5.6 nM, respectively.

    Features:The first, typical antipsychotic drug of the thioxanthene class to be synthesized.

  • Quetiapine Fumarate

    Quetiapine Fumarate is an atypical antipsychotic used in the treatment of schizophrenia, bipolar I mania, bipolar II depression, bipolar I depression.

  • Levodopa

    Levodopa is the precursor to the neurotransmitters dopamine, norepinephrine (noradrenaline), and epinephrine (adrenaline), used to treat Parkinson's symptoms.

  • Pramipexole

    Pramipexole is a partial/full D2S, D2L, D3, D4 receptor agonist with a Ki of 3.9, 2.2, 0.5 and 5.1 nM for D2S, D2L, D3, D4 receptor, respectively.

  • Dopamine HCl

    Dopamine HCl is a catecholamine neurotransmitter present in a wide variety of animals,And a dopamine D1-5 receptors agonist.

  • Rotundine

    Rotundine (L-tetrahydropalmatine, L-THP) is a selective dopamine D1 receptor antagonist with IC50 of 166 nM.

Recently Viewed Items

Tags: buy Rotigotine | Rotigotine supplier | purchase Rotigotine | Rotigotine cost | Rotigotine manufacturer | order Rotigotine | Rotigotine distributor
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Contact Us