Rotigotine

Catalog No.S4274

Rotigotine is a dopamine receptor agonist, used in the treatment of Parkinson's disease and restless legs syndrome.

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Rotigotine Chemical Structure

Rotigotine Chemical Structure
Molecular Weight: 315.47

Validation & Quality Control

Quality Control & MSDS

Product Information

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Product Description

Biological Activity

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDog
Weight (kg)0.020.151.80.40.0810
Body Surface Area (m2)0.0070.0250.150.050.020.5
Km factor36128520
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)

Clinical Trial Information( data from http://clinicaltrials.gov, updated on 2016-06-18)

NCT Number Recruitment Conditions Sponsor
/Collaborators
Start Date Phases
NCT02728947 Recruiting Parkinsons Disease Luye Pharma Group Ltd. May 2016 Phase 1
NCT02365870 Not yet recruiting Anxiety Disorders|Parkinson Disease Johns Hopkins University|National Institute on Aging (NIA) May 2015 Phase 4
NCT02230904 Completed Parkinsons Disease UCB BIOSCIENCES GmbH|Pharmaceutical Health Sciences|Brack  ...more UCB BIOSCIENCES GmbH|Pharmaceutical Health Sciences|Bracket Global|UCB Pharma September 2014 Phase 1
NCT01976871 Active, not recruiting Restless Legs Syndrome|Ekbom Syndrome|Willis-Ekbom Disease John Winkelman, MD, PhD|Massachusetts General Hospital August 2014 Phase 4
NCT02070796 Completed Healthy UCB Pharma SA|UCB Pharma February 2014 Phase 1

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Chemical Information

Download Rotigotine SDF
Molecular Weight (MW) 315.47
Formula

C19H25NOS

CAS No. 99755-59-6
Storage 3 years -20℃powder
6 months-80℃in solvent
Synonyms N/A
Solubility (25°C) * In vitro DMSO 63 mg/mL (199.7 mM)
Ethanol 63 mg/mL (199.7 mM)
Water <1 mg/mL (<1 mM)
In vivo
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Name 5,6,7,8-tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-(6S)-1-naphthalenol

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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