Rotigotine

Catalog No.S4274

Rotigotine Chemical Structure

Molecular Weight(MW): 315.47

Rotigotine is a dopamine receptor agonist, used in the treatment of Parkinson's disease and restless legs syndrome.

Size Price Stock Quantity  
USD 97 In stock
USD 377 In stock
USD 847 In stock

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Purity & Quality Control

Choose Selective Dopamine Receptor Inhibitors

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Notes:

2. For more details, such as half maximal inhibitory concentrations (IC50s) and working concentrations of each inhibitor, please click on the link of the inhibitor of interest.
3. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
4. Orange "√" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

Biological Activity

Description Rotigotine is a dopamine receptor agonist, used in the treatment of Parkinson's disease and restless legs syndrome.
Targets
Dopamine receptor [1]

Protocol

References

Solubility (25°C)

In vitro DMSO 63 mg/mL (199.7 mM)
Ethanol 63 mg/mL (199.7 mM)
Water <1 mg/mL
In vivo

* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 315.47
Formula

C19H25NOS

CAS No. 99755-59-6
Storage powder
in solvent
Synonyms N/A

Bio Calculators

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Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
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Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02728947 Recruiting Parkinsons Disease Luye Pharma Group Ltd. May 2016 Phase 1
NCT02365870 Not yet recruiting Anxiety Disorders|Parkinson Disease Johns Hopkins University|National Institute on Aging (NIA) May 2015 Phase 4
NCT02230904 Completed Parkinsons Disease UCB BIOSCIENCES GmbH|Pharmaceutical Health Sciences|Bracket Global|UCB Pharma September 2014 Phase 1
NCT01976871 Active, not recruiting Restless Legs Syndrome|Ekbom Syndrome|Willis-Ekbom Disease John Winkelman, MD, PhD|Massachusetts General Hospital August 2014 Phase 4
NCT02070796 Completed Healthy UCB Pharma SA|UCB Pharma February 2014 Phase 1
NCT02103465 Terminated Parkinsons Disease Azienda Ospedaliera Cardinale G. Panico December 2013 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Dopamine Receptor Signaling Pathway Map

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