Metoclopramide HCl

Catalog No.S4289

Metoclopramide HCl is a selective dopamine D2 receptor antagonist, used for the treatment of nausea and vomiting.

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Metoclopramide HCl Chemical Structure

Metoclopramide HCl Chemical Structure
Molecular Weight: 336.26

Validation & Quality Control

Quality Control & MSDS

Product Information

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Product Description

Biological Activity

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDog
Weight (kg)0.020.151.80.40.0810
Body Surface Area (m2)0.0070.0250.150.050.020.5
Km factor36128520
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)

Clinical Trial Information( data from http://clinicaltrials.gov, updated on 2016-06-25)

NCT Number Recruitment Conditions Sponsor
/Collaborators
Start Date Phases
NCT02582996 Not yet recruiting Migraine Ache Laboratorios Farmaceuticos S.A. January 2017 Phase 3
NCT02784392 Not yet recruiting Enteral Feeding Intolerance (EFI) Lyric Pharmaceuticals July 2016 Phase 2
NCT02625181 Not yet recruiting Postoperative Nausea and Vomiting Vanderbilt University|University of Washington May 2016 --
NCT02262923 Not yet recruiting in Vitro Fertilization|Poor Responder Mount Sinai Hospital, Canada March 2016 --
NCT02681211 Enrolling by invitation Migraine Headache University of Louisville February 2016 --

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Chemical Information

Download Metoclopramide HCl SDF
Molecular Weight (MW) 336.26
Formula

C14H23Cl2N3O2

CAS No. 7232-21-5
Storage 3 years -20℃powder
6 months-80℃in solvent
Synonyms N/A
Solubility (25°C) * In vitro DMSO 67 mg/mL warming (199.25 mM)
Water 67 mg/mL (199.25 mM)
Ethanol 67 mg/mL (199.25 mM)
In vivo
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Name 4-amino-5-chloro-N-(2-(diethylamino)ethyl)-o-anisamide monohydrochloride

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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