Metoclopramide HCl

Catalog No.S4289

Metoclopramide HCl is a selective dopamine D2 receptor antagonist, used for the treatment of nausea and vomiting.

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Metoclopramide HCl Chemical Structure

Metoclopramide HCl Chemical Structure
Molecular Weight: 336.26

Validation & Quality Control

Quality Control & MSDS

Related Compound Libraries

Metoclopramide HCl is available in the following compound libraries:

Product Information

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Product Description

Biological Activity

Description Metoclopramide HCl is a selective dopamine D2 receptor antagonist, used for the treatment of nausea and vomiting.
Targets D2 receptor [1]
In vitro
In vivo

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDog
Weight (kg)
Body Surface Area (m2)0.0070.0250.
Km factor36128520
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)


Clinical Trial Information( data from, updated on 2016-07-30)

NCT Number Recruitment Conditions Sponsor
Start Date Phases
NCT02582996 Not yet recruiting Migraine Ache Laboratorios Farmaceuticos S.A. January 2017 Phase 3
NCT02847494 Not yet recruiting Migraine Montefiore Medical Center August 2016 Phase 4
NCT02784392 Recruiting Enteral Feeding Intolerance (EFI) Lyric Pharmaceuticals July 2016 Phase 2
NCT02625181 Recruiting Postoperative Nausea and Vomiting Vanderbilt University|University of Washington July 2016 --
NCT02262923 Not yet recruiting in Vitro Fertilization|Poor Responder Mount Sinai Hospital, Canada March 2016 --

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Chemical Information

Download Metoclopramide HCl SDF
Molecular Weight (MW) 336.26


CAS No. 7232-21-5
Storage 3 years -20℃powder
2 years -80℃in solvent
Synonyms N/A
Solubility (25°C) * In vitro DMSO 67 mg/mL warming (199.25 mM)
Water 67 mg/mL (199.25 mM)
Ethanol 67 mg/mL (199.25 mM)
In vivo
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Name 4-amino-5-chloro-N-(2-(diethylamino)ethyl)-o-anisamide monohydrochloride

Tech Support

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