Domperidone

Catalog No.S2461

Domperidone  Chemical Structure

Molecular Weight(MW): 425.91

Domperidone is an oral dopamine D2 receptor antagonist, used to treat nausea and vomiting.

Size Price Stock Quantity  
In DMSO USD 130 In stock
USD 97 In stock
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Biological Activity

Description Domperidone is an oral dopamine D2 receptor antagonist, used to treat nausea and vomiting.
Targets
Dopamine D2 receptor [1]
In vitro

Domperidone (a D2R antagonist) inhibits Equilibrative NT1 (ENT1) activity more in the presence than in the absence of Bromocriptine and displays an IC50 value lower than that of Bromocriptine or Ergovaline in Madin-Darby bovine kidney (MDBK) cells. [1]

In vivo Domperidone (0.1 mg/kg) results in a significant decrease in feeding behavior and stimulation of basal metabolism, but has no effect on locomotor activity of rats in a Phenomaster system. [2] Domperidone (1.1 mg/kg and 5.5 mg/kg, oral) significantly increases laminar microvascular blood flow (LMBF) in horses, compared with baseline values, beginning 4 hours after administration, and this effect persisted for at least 8 hours. Domperidone (0.2 mg/kg, i.v.) significantly increases laminar microvascular blood flow (LMBF) in horses, compared with baseline values, at 10 and 12 hours after administration. [3] Domperidone can ameliorate deleterious reproductive effects and reduce weight gain associated with fescue toxicosis in heifers. [4] Domperidone-treated mares have shorter gestation duration and foaled closer to their expected parturition date than did control mares. Domperidone-treated mares have higher Mammary gland scores and serum prolactin concentration. [5] Domperidone (5 mg/kg, oral) increases peak plasma acetaminophen concentration and area under the curve in rats, indicating increased gastric emptying. Domperidone decreases the dopamine-induced contractile activity of midjejunal longitudinal muscle strips in rats. [6]

Protocol

Solubility (25°C)

In vitro DMSO 48 mg/mL (112.69 mM)
Ethanol 1 mg/mL (2.34 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 425.91
Formula

C22H24ClN5O2

CAS No. 57808-66-9
Storage powder
Synonyms N/A

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02699385 Recruiting Gastroenteritis Janssen-Cilag International NV June 2016 Phase 3
NCT02816853 Completed Healthy Janssen Research & Development, LLC May 2016 Phase 1
NCT02980250 Enrolling by invitation Feeding Intolerance|Premature Birth|Domperidone Nanfang Hospital of Southern Medical University|Guangdong Provincial Maternal and Child Health Hospital|Shen-Zhen City Maternity and Child Healthcare Hospital|Maternal and Child Health Hospital of Foshan|Maternal and Child Health Hospital,Huadu District|Guangzhou Panyu Central Hospital November 2015 Phase 4
NCT02493049 Enrolling by invitation Multiple Sclerosis, Relapsing-Remitting University of Calgary|Alberta Innovates Health Solutions August 2015 Phase 2
NCT02757534 Recruiting Gastroparesis Assouline-Dayan, Yehudith|University of Iowa May 2015 Phase 2
NCT02308137 Recruiting Multiple Sclerosis, Secondary Progressive University of Calgary|Alberta Innovates Health Solutions February 2015 Phase 2

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Dopamine Receptor Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID