Name: Chlorpromazine HCl
Brand: Selleck Chemicals
SKU: S2456
Rating: 5 (24 reviews)

Chlorpromazine HCl is a dopamine and potassium channel inhibitor with IC50 of 6.1 and 16 μM for inward-rectifying K+ currents and time-independent outward currents.

Chlorpromazine HCl Chemical Structure

CAS: 69-09-0

Selleck's Chlorpromazine HCl has been cited by 24 Publications

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Purity & Quality Control

Batch: Purity: 99.96%

99.96

Chlorpromazine HCl Related Products

Related Targets	D1 receptor D2 receptor D3 receptor D5 receptor DAT D4 receptor	Click to Expand
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Signaling Pathway

Dopamine Receptor Signaling Pathway

Choose Selective Dopamine Receptor Inhibitors

Cell Data

Cell Lines	Assay Type	Activity Description	PMID
CHO cells	Function assay	Compound was evaluated for the binding affinity against [3H]8-OH-DPAT-labeled 5-hydroxytryptamine 1A receptor sites in cloned CHO cells, Ki=0.673 μM	8097538
CHO cells	Function assay	Compound was evaluated for the binding affinity against [3H]U-86,170-labeled D2 sites in cloned CHO cells, Ki=0.003 μM	8097538
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Biological Activity

Description

Chlorpromazine HCl is a dopamine and potassium channel inhibitor with IC50 of 6.1 and 16 μM for inward-rectifying K+ currents and time-independent outward currents.

Targets

Dopamine receptor ^[6]

Potassium channel ^[6]

In vitro
In vitro	Chlorpromazine affects miniature IPSCs (mIPSCs) by decreasing the binding (kon) and by increasing the unbinding (koff) rates of GABAARs. ^[1] Chlorpromazine modulates activated TRPA1 currents in a voltage-dependent way, leading to a block at positive potentials and an increased open probability at negative potentials. ^[2]

In Vivo
In vivo	Chlorpromazine independently down-regulates the production of various T cell-derived lymphokines (IL-2, IFN-gamma, IL-4, TNF, and GM-CSF) and up-regulates the secretion of IL-10 in an in vivo model of acute superantigen-driven immune activation. Chlorpromazine -mediated amplification of the SEB-driven Chlorpromazine secretion is accompanied by an enhanced IL-10 mRNA accumulation. ^[3] Chlorpromazine protects mice, normal or adrenalectomized, and guinea pigs against lethality of LPS, and inhibits TNF serum levels. Chlorpromazine protects against LPS lethality when administered 30 minutes (min) before, simultaneously, or up to 10 min after LPS and is ineffective when given 30 min after LPS, paralleling the inhibitory effect on TNF production. Chlorpromazine significantly inhibits LPS lethality and hepatotoxicity in mice sensitized to LPS toxicity by actinomycin D, whereas under these conditions DEX is inactive. ^[4] Chlorpromazine protects brain tissue from hypoxia-induced irreversible loss of synaptic transmission in rats. Chlorpromazine also significantly delays the occurrence of the hypoxia-induced spreading depression (SD) in rats. ^[5]

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT05206747	Recruiting	Mania\|Sleep\|Bipolar Disorder	Ottawa Hospital Research Institute	September 7 2022	Not Applicable
NCT03548714	Completed	Alcohol Dependence\|Alcohol Interaction	Pop Test Oncology LLC\|Pharmacotherapies for Alcohol and Substance Use Disorders Alliance\|Congressionally Directed Medical Research Programs\|Michael E. DeBakey VA Medical Center\|Baylor College of Medicine\|University of California San Diego	September 1 2018	Phase 1
NCT02943213	Completed	Anti-Psychotic\|Management of Manifestations of Psychotic Disorders\|Treatment of Schizophrenia\|Control Nausea and Vomiting\|Relief of Restlessness and Apprehension Before Surgery\|Acute Intermittent Porphyria\|Adjunct in the Treatment of Tetanus\|Control Manifestations of the Manic Type of Mani-depressive Illness\|Relief of Intractable Hiccups	Cycle Pharmaceuticals Ltd.\|Parexel	November 2016	Phase 1

References

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Chemical Information & Solubility

Molecular Weight	355.33	Formula	C₁₇H₁₉ClN₂S.HCl
CAS No.	69-09-0	SDF	Download Chlorpromazine HCl SDF
Smiles	CN(C)CCCN1C2=CC=CC=C2SC3=C1C=C(C=C3)Cl.Cl
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 71 mg/mL ( (199.81 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 71 mg/mL

Ethanol : 71 mg/mL

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In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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