Levodopa

Catalog No.S1726

Levodopa  Chemical Structure

Molecular Weight(MW): 197.19

Levodopa is the precursor to the neurotransmitters dopamine, norepinephrine (noradrenaline), and epinephrine (adrenaline), used to treat Parkinson's symptoms.

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  • (A) A focused screening of Aβ generation in response to levodopa, piribedil, bromocriptine or carbidopa at indicated concentrations in SK-N-SH cells. Data are mean ± s.e.m., n = 3-4. *p < 0.05; ***p < 0.001 versus the control of each group.

    PLoS ONE, 12(3), e0173240. Levodopa purchased from Selleck.

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Biological Activity

Description Levodopa is the precursor to the neurotransmitters dopamine, norepinephrine (noradrenaline), and epinephrine (adrenaline), used to treat Parkinson's symptoms.
Targets
Dopamine receptor [1]
In vitro

Levodopa produces at 25-200 μM concentrations a dose-dependent reduction of 3H-DA uptake in foetal rat midbrain cultures. Levodopa results in a decrease in the number of viable cells and tyrosine hydroxylase (TH) positive neurones, plus disruption of the overall neuritic network. [1] Levodopa induces dyskinesia in the absence of dopamine by excessive inhibition of neurons of the putamen-globus pallidus (GPe) projection and subsequent disinhibition of the globus pallidus (GPe). Levodopa results in a decrease in cytochrome oxidase messenger RNA expression in the globus pallidus (GPi). [2]

In vivo Levodopa elicits the development of a variety of abnormal movements in monkeys with parkinsonism induced by the neurotoxin MPTP. Levodopa administrations result in an ectopic induction of the dopamine D3receptor expression in the CdPu in 6-OHDA-lesioned rats. [3] Levodopa (50 mg/kg) increases anandamide concentrations throughout thebasal ganglia via activation of dopamine D1/D2 receptors in intact rats. Levodopa produces increasingly severe oro-lingual involuntary movements which are attenuated by the cannabinoid agonist R(+)-WIN55,212-2 (1 mg/kg) in lesioned rats. [4] Levodopa administration reverses the up-regulation of D2 dopamine receptors seen in severely lesioned rats provided evidence that Levodopa reaches a biologically active concentration at the basal ganglia. [5]

Protocol

Solubility (25°C)

In vitro DMSO Insoluble
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 197.19
Formula

C9H11NO4

CAS No. 59-92-7
Storage powder
Synonyms N/A

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00089622 Completed Parkinson Disease National Institute of Neurological Disorders and Stroke (NINDS)|National Institutes of Health Clinical Center (CC) August 4, 2004 Phase 2
NCT00086294 Completed Parkinsons Disease|Dyskinesias National Institute of Neurological Disorders and Stroke (NINDS)|National Institutes of Health Clinical Center (CC) June 25, 2004 Phase 2
NCT02873351 Not yet recruiting Age-related Macular Degeneration Snyder, Robert W., M.D., Ph.D., P.C. September 2018 Phase 2
NCT03023059 Not yet recruiting Age-related Macular Degeneration Snyder, Robert W., M.D., Ph.D., P.C. March 2017 Phase 2
NCT03022318 Not yet recruiting Age-related Macular Degeneration Snyder, Robert W., M.D., Ph.D., P.C. March 2017 Phase 2
NCT03000569 Recruiting Parkinson Disease Sage Therapeutics December 2016 Phase 2

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Dopamine Receptor Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID