Caspase

Sigaling Pathway Map

Research Area

  • Inhibitory Selectivity
  • Solubility
Catalog No. Product Name Solubility(25°C)
Water DMSO Alcohol
S2228 Belnacasan (VX-765) <1 mg/mL 100 mg/mL 100 mg/mL
S2738 PAC-1 <1 mg/mL 78 mg/mL 16 mg/mL
S2927 Apoptosis Activator 2 <1 mg/mL 61 mg/mL <1 mg/mL
S7326 Tasisulam <1 mg/mL 83 mg/mL 83 mg/mL
S7023 Z-VAD-FMK <1 mg/mL 93 mg/mL <1 mg/mL
S7312 Z-DEVD-FMK <1 mg/mL 100 mg/mL <1 mg/mL
S7314 Z-IETD-FMK <1 mg/mL 91 mg/mL <1 mg/mL
S7775 Emricasan <1 mg/mL 100 mg/mL 100 mg/mL
S8292 Selonsertib (GS-4997) <1 mg/mL 36 mg/mL 24 mg/mL
S8289 NQDI-1 <1 mg/mL 21 mg/mL <1 mg/mL
S7311 Q-VD-OPh <1 mg/mL 100 mg/mL 100 mg/mL
S2448 Gambogic Acid <1 mg/mL 100 mg/mL 100 mg/mL
S8102 Z-VAD-FMK (Caspase Inhibitor VI) <1 mg/mL 90 mg/mL 90 mg/mL

Isoform-specific Inhibitors

Catalog No. Information Product Use Citations Product Validations
S2228

Belnacasan (VX-765)

Belnacasan (VX-765) is a potent and selective inhibitor of caspase-1 with Ki of 0.8 nM in a cell-free assay. Phase 2.

S7023

Z-VAD-FMK

Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor, blocks all features of apoptosis in THP.1 and Jurkat T-cells.

S7312New

Z-DEVD-FMK

Z-DEVD-FMK is a specific, irreversible Caspase-3 inhibitor, and also shows potent inhibition on caspase-6, caspase-7, caspase-8, and caspase-10.

S7314New

Z-IETD-FMK

Z-IETD-FMK is a specific Caspase-8 inhibitor.

S7775New

Emricasan

Emricasan is a potent irreversible pan-caspase inhibitor.

S8292New

Selonsertib (GS-4997)

GS-4997 is a highly selective and potent once-daily oral ASK1 inhibitor with potential anti-inflammatory, antineoplastic and anti-fibrotic activities.

S8289New

NQDI-1

NQDI 1, an inhibitor of ASK1(apoptosis signal-regulating kinase 1), attenuates acute ischemic renal injury by modulating oxidative stress and cell death.

S7311

Q-VD-OPh

Q-VD-OPh is a potent pan-caspase inhibitor with IC50 ranging from 25 to 400 nM for caspases 1, 3, 8, and 9, showing inhibitory effects on terminal caspase activation, substrate cleavage, and DNA ladder formation associated with apoptosis.

S8102

Z-VAD-FMK (Caspase Inhibitor VI)

Z-VAD-FMK (Caspase Inhibitor VI) is an irreversible pan-caspase inhibitor.

S2738

PAC-1

PAC-1 is a potent procaspase-3 activator with EC50 of 0.22 μM and the first small molecule known to directly activate procaspase-3 to caspase-3.

S2927

Apoptosis Activator 2

Apoptosis Activator 2 strongly induces caspase-3 activation, PARP cleavage, and DNA fragmentation which leads to the destruction of cells (Apaf-1 dependent) with IC50 of ~4 μM, inactive to HMEC, PREC, or MCF-10A cells.

S7326

Tasisulam

Tasisulam is an antitumor agent and an apoptosis inducer via the intrinsic pathway. Phase 3.

S2448

Gambogic Acid

Gambogic Acid activates caspases with EC50 of 0.78-1.64 μM and competitively inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 with IC50 of 1.47, 1.21, 2.02, 0.66, 1.06 and 0.79 μM, respectively.

Catalog No. Information Product Use Citations Product Validations
S2228

Belnacasan (VX-765)

Belnacasan (VX-765) is a potent and selective inhibitor of caspase-1 with Ki of 0.8 nM in a cell-free assay. Phase 2.

S7023

Z-VAD-FMK

Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor, blocks all features of apoptosis in THP.1 and Jurkat T-cells.

S7312New

Z-DEVD-FMK

Z-DEVD-FMK is a specific, irreversible Caspase-3 inhibitor, and also shows potent inhibition on caspase-6, caspase-7, caspase-8, and caspase-10.

S7314New

Z-IETD-FMK

Z-IETD-FMK is a specific Caspase-8 inhibitor.

S7775New

Emricasan

Emricasan is a potent irreversible pan-caspase inhibitor.

S8292New

Selonsertib (GS-4997)

GS-4997 is a highly selective and potent once-daily oral ASK1 inhibitor with potential anti-inflammatory, antineoplastic and anti-fibrotic activities.

S8289New

NQDI-1

NQDI 1, an inhibitor of ASK1(apoptosis signal-regulating kinase 1), attenuates acute ischemic renal injury by modulating oxidative stress and cell death.

S7311

Q-VD-OPh

Q-VD-OPh is a potent pan-caspase inhibitor with IC50 ranging from 25 to 400 nM for caspases 1, 3, 8, and 9, showing inhibitory effects on terminal caspase activation, substrate cleavage, and DNA ladder formation associated with apoptosis.

S8102

Z-VAD-FMK (Caspase Inhibitor VI)

Z-VAD-FMK (Caspase Inhibitor VI) is an irreversible pan-caspase inhibitor.

Catalog No. Information Product Use Citations Product Validations
S2738

PAC-1

PAC-1 is a potent procaspase-3 activator with EC50 of 0.22 μM and the first small molecule known to directly activate procaspase-3 to caspase-3.

2015, 10.4172/0974-8369.1000259

S2927

Apoptosis Activator 2

Apoptosis Activator 2 strongly induces caspase-3 activation, PARP cleavage, and DNA fragmentation which leads to the destruction of cells (Apaf-1 dependent) with IC50 of ~4 μM, inactive to HMEC, PREC, or MCF-10A cells.

S7326

Tasisulam

Tasisulam is an antitumor agent and an apoptosis inducer via the intrinsic pathway. Phase 3.

S2448

Gambogic Acid

Gambogic Acid activates caspases with EC50 of 0.78-1.64 μM and competitively inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 with IC50 of 1.47, 1.21, 2.02, 0.66, 1.06 and 0.79 μM, respectively.

Tags: Caspases apoptosis | Caspase inhibition | Caspase activation | Caspase activity | Caspase pathway | Caspase phosphorylation | Caspase cleavage | Caspase activity assay | Procaspase activation | Caspase inhibitor in vivo | Caspase inhibitor clinical trial | Caspase-independent apoptosis | Caspase-dependent apoptosis | Caspase inhibitor review