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Caspase Inhibitors | Activators (9)


Cat.No. Product Name Information Product Citations Customer Reviews
S2738 PAC-1 PAC-1 is a potent procaspase-3 activator with EC50 of 0.22 μM and the first small molecule known to directly activate procaspase-3 to caspase-3.
S2228 VX-765 VX-765 is a potent and selective inhibitor of caspase-1 with Ki of 0.8 nM.
S2927 Apoptosis Activator 2 Apoptosis Activator 2 strongly induces caspase-3 activation, PARP cleavage, and DNA fragmentation which leads to the destruction of cells (Apaf-1 dependent) with IC50 of ~4 μM, inactive to HMEC, PREC, or MCF-10A cells.
S7023 Z-VAD-FMK Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor, blocks all features of apoptosis.
  • Leuk Res, 2013, 37(10):1302-8
S7314 Z-IETD-FMK Z-IETD-FMK is a specific Caspase-8 inhibitor.
S7313 Z-LEHD-FMK Z-LEHD-FMK is a specific, irreversible Caspase-9 inhibitor.
S7312 Z-DEVD-FMK Z-DEVD-FMK is a specific, irreversible Caspase-3 inhibitor, and also shows potent inhibition on caspase-6, caspase-7, caspase-8, and caspase-10.
S7311 Q-VD-OPh Q-VD-OPh is a potent pan-caspase inhibitor with IC50 ranging from 25 to 400 nM for caspases 1, 3, 8, and 9, showing inhibitory effects on terminal caspase activation, substrate cleavage, and DNA ladder formation associated with apoptosis.
S7326 Tasisulam Tasisulam is an antitumor agent and an apoptosis inducer via the intrinsic pathway. Phase 3
Tags: Caspases apoptosis | Caspase inhibition | Caspase activation | Caspase activity | Caspase pathway | Caspase phosphorylation | Caspase cleavage | Caspase activity assay | Procaspase activation | Caspase inhibitor in vivo | Caspase inhibitor clinical trial | Caspase-independent apoptosis | Caspase-dependent apoptosis | Caspase inhibitor review